furegrelate has been researched along with benzofurans in 104 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (39.42) | 18.7374 |
| 1990's | 27 (25.96) | 18.2507 |
| 2000's | 27 (25.96) | 29.6817 |
| 2010's | 7 (6.73) | 24.3611 |
| 2020's | 2 (1.92) | 2.80 |
| Authors | Studies |
|---|---|
| Gray-Weale, A; Huber, D; Joseph, M; Langsfeld, M; Lusby, RJ; Meyer, JH; Payne, JE; Smith, T | 1 |
| Bolling, SF; Deeb, GM; Grum, CM; Ljungman, AG; Morganroth, ML | 1 |
| Stanley, JC; Wakefield, TW; Wang, TW; Wirthlin, DJ; Wrobleski, SK | 1 |
| Ji, TH; Murdoch, WJ; Slaughter, RG; Van Kirk, EA; Wilken, C | 1 |
| Glovsky, MM; Horvath, SJ; Morganroth, ML; Schoeneich, SO; Till, GO; Ward, PA | 1 |
| Bech, FR; Cronenwett, JL; Freeman, DH; McDaniel, MD; Ogletree, ML | 1 |
| Chandna, VK; Donnelly, WH; Mehta, JL; Nichols, WW; Schofield, R | 1 |
| Freeman, D; Keown, P; McDonald, J; Petric, R; Stiller, C; Wallace, C | 1 |
| Kaushal, RD; Wilson, TW | 1 |
| Lakings, DB; Mohrland, JS; Vander Lugt, JT | 1 |
| Bennett, WM; Scoggins, BA; Tresham, JJ; Whitworth, JA | 1 |
| Clark, WF; Kreeft, J; McDonald, JW; Parbtani, A; Reid, BD; Taylor, N | 1 |
| Crowell, RE; Reed, WP; Van Epps, DE | 1 |
| Franzini, D; Lawson, D; Mehta, J; Nichols, WW; Wargovich, TJ | 1 |
| Lawson, DL; Mehta, JL; Nichols, WW | 1 |
| Brothers, TE; Burkel, WE; Darvishian, D; Graham, LM; Harrell, KA; Stanley, JC; Vincent, CK | 1 |
| Gorman, RR; Lakings, DB; Mohrland, JS; Vander Lugt, JT | 1 |
| Friis, JM; Lakings, DB; Lunan, CM; Mohrland, JS; VanderLugt, JT | 1 |
| Regal, JF | 2 |
| Lawson, D; Mehta, JL; Mehta, P | 1 |
| Stein, E; Trachte, GJ | 1 |
| Cumming, AD; Lindsay, RM; Linton, AL; McDonald, JW; Solez, K | 1 |
| Friehling, TD; Kowey, PR; O'Connor, KM | 1 |
| Evancho, MM; Falkow, LJ; Hunter, TJ; Schmidt, SP; Sharp, WV | 1 |
| Gréen, K; Vesterqvist, O | 1 |
| Cronenwett, JL; Huntsman, WT; McDaniel, MD; Miett, TO | 1 |
| Fenelon, LC; Fitzgerald, DJ; FitzGerald, GA; Fragetta, J | 1 |
| Hall, ED; Wolf, DL | 1 |
| Datar, S; McCauley, FA; Wilson, TW | 2 |
| Anderson, CB; Freeman, MB; Mangino, MJ; Neuberger, S; Sicard, GA; Valentin, LI | 1 |
| Kaldunski, ML; Mattson, DL; Mistry, M; Nasjletti, A; Roman, RJ | 1 |
| Cumming, AD; Lindsay, RM; Linton, AL; McDonald, JW | 1 |
| Chou, CC; Mangino, MJ | 2 |
| Hammon, JW; Oates, JA | 1 |
| Keith, JC; Schaub, RG; Thatcher, CD | 1 |
| Anner, H; Hechtman, HB; Kaufman, RP; Kobzik, L; Shepro, D; Valeri, CR | 1 |
| Askins, R; Cargile, M; Hebeler, RF; Neyman, SL; O'Leary, JP | 1 |
| Boorstein, JM; Cronenwett, JL; Endean, ED; Hees, PL | 1 |
| Aiken, JW; Crittenden, NJ; Gorman, RR; Johnson, RA; Nidy, EG | 1 |
| Hock, CE; Lefer, AM; Phillips, GR | 1 |
| Hall, ED | 1 |
| Friis, JM; Lakings, DB | 1 |
| Jackson, EK | 1 |
| Clozel, M; Clyman, RI; Heymann, MA; Soifer, SJ | 1 |
| Black, KL; Hoff, JT; Hsu, S; Radin, NS | 1 |
| Aiken, JW; Gorman, RR; Johnson, RA; Spilman, CH | 1 |
| Honn, KV; Onoda, JM; Sloane, BF | 1 |
| Hock, CE; Lefer, AM | 1 |
| Fitzpatrick, FA; Liggett, WF; Wynalda, MA | 1 |
| Cumming, AD | 2 |
| Akima, M; Hamana, M; Kamei, K; Koga, T; Kuroki, T; Maruyama, N; Ohi, N; Yamaguchi, M | 1 |
| Krupa, SM; Lane, PH; Reddington, JC; Salinas-Madrigal, L; Schmitz, PG | 1 |
| Badahman, AH; Wilson, TW | 1 |
| Hales, CA; Hutchison, WG; Janssens, SP; Jung, W; Musto, SW; Spence, C; Witten, M | 1 |
| Badahman, AH; Kaushal, RD; Wilson, TW | 1 |
| Belzer, FO; Saunder, A; Schilling, M; Southard, JH | 3 |
| Ametani, M; Belzer, FO; Saunder, A; Schilling, M; Southard, JH | 1 |
| Chen, S; Li, JW; Ma, SX; Wang, Y; Yan, YH | 1 |
| Forster, H; Takenaka, T | 1 |
| Brands, MW; Hall, JE; Keen, HL; Shek, EW; Smith, MJ | 1 |
| Bresnahan, BA; Dufek, S; Lianos, EA; Wu, S | 1 |
| Chen, Y; Honn, KV; Lamberti, M; Li, L; Nie, D; Szekeres, K; Tang, K; Zacharek, A | 1 |
| Murakami, Y; Nishihara, M; Okada, S; Osumi, Y; Yokotani, K | 1 |
| Dalal, R; Schmitz, PG; Zhang, K | 1 |
| Huang, A; Koller, A; Sun, D | 1 |
| Madan, ZM; Sainani, GS | 1 |
| Barrett, TD; Crofford, LJ; Driscoll, EM; Hennan, JK; Huang, J; Lucchesi, BR; Park, AM; Willens, DE | 1 |
| Berens, ME; Djawaheri, J; Giese, A; Hagel, C; Kim, EL; Westphal, M; Zapf, S | 1 |
| McCarthy, ET; Sharma, M | 1 |
| Hilbun, LR; Pallone, TL; Silldorff, EP | 1 |
| Murakami, Y; Okada, S; Yokotani, K | 1 |
| Jungermann, K; Nath, A; Pestel, S; Schieferdecker, HL | 1 |
| Giese, A; Jantke, J; Kim, E; Kürzel, F; Ladehoff, M; Zapf, S | 1 |
| Clemens, MG; Karaa, A; Korneszczuk, K; Lin, T; Xu, H; Zhang, JX | 1 |
| Duckles, SP; Ghaffari, AA; Gonzales, RJ; Krause, DN | 1 |
| Arai, J; Nakamura, K; Okada, S; Shimizu, T; Wakiguchi, H; Yamaguchi-Shima, N; Yokotani, K | 1 |
| Acosta Cazal, MC; Fortepiani, LA; Reckelhoff, JF; Santacruz, F | 1 |
| Cavun, S; Cengiz, F; Savci, V; Yalcin, M; Yilmaz, MS | 1 |
| Ak, F; Erturk, M; Yalcin, M | 1 |
| Lu, L; Okada, S; Sasaki, T; Shimizu, T; Yamaguchi, N; Yokotani, K | 1 |
| Lu, L; Nakamura, K; Okada, S; Shimizu, T; Usui, D; Yamaguchi-Shima, N; Yokotani, K | 1 |
| Gendron, ME; Thorin, E | 1 |
| Ansari, HR; Mustafa, SJ; Nadeem, A; Tilley, SL | 1 |
| Aras-López, R; Balfagón, G; del Campo, L; Ferrer, M; Sagredo, A | 1 |
| Sasaki, T; Shimizu, T; Wakiguchi, H; Yokotani, K | 1 |
| Alonso, MJ; Beltrán, AE; Briones, AM; García-Redondo, AB; Salaices, M; Simonsen, U | 1 |
| Brockmann, MA; Giese, A; Kim, EL; Leppert, J; Nadrowitz, R; Schauff, AK; Wuestenberg, R | 1 |
| Destache, CJ; Ohia, SE; Opere, CA; Zhao, M | 1 |
| Aras-López, R; Balfagón, G; Ferrer, M; Martorell, A; Sagredo, A | 1 |
| Yalcin, M | 1 |
| Bolduc, V; Drouin, A; Farhat, N; Gillis, MA; Nguyen, A; Thorin, E; Thorin-Trescases, N; Villeneuve, L | 1 |
| Hou, MC; Huang, YT; Lee, FY; Lee, SD; Lin, HC; Tsai, TH; Yang, YY | 1 |
| Chen, GG; Guo, HZ; Huang, RY; Huang, Y; Li, MY; Li, SS; Zeng, X; Zhang, X | 1 |
| Alcay, S; Altinbas, B; Erkan, LG; Guvenc, G; Toker, MB; Udum Kucuksen, D; Ustuner, B; Yalcin, M | 1 |
| Altinbas, B; Erkan, LG; Guvenc, G; Niaz, N; Yalcin, M | 1 |
| Addison, MP; Choudhury, S; Darzi, SA; Kandasamy, K; Kasa, JK; Kumar, D; Mishra, SK; Parida, S; Singh, TU; Singh, V; Sukumaran, SV | 1 |
| Okada, S; Tachi, M; Yamaguchi, N | 1 |
| Abdelazeem, H; Aljesri, K; Norel, X; Ozen, G; Topal, G; Turkyılmaz, G; Turkyılmaz, S | 1 |
1 review(s) available for furegrelate and benzofurans
| Article | Year |
|---|---|
Acute renal failure and sepsis: therapeutic approaches.
Topics: Acute Kidney Injury; Animals; Aprotinin; Benzofurans; Glomerular Filtration Rate; Humans; Kallikrein-Kinin System; Natriuresis; Peritonitis; Sepsis; Sheep; Thromboxane-A Synthase | 1994 |
2 trial(s) available for furegrelate and benzofurans
| Article | Year |
|---|---|
Effects of Furegrelate (Upjohn 63557A) on patency and platelet deposition after canine carotid endarterectomy.
Topics: Animals; Benzofurans; Carotid Arteries; Carotid Artery Thrombosis; Constriction; Dogs; Endarterectomy; Indium Radioisotopes; Male; Platelet Adhesiveness; Platelet Aggregation; Prospective Studies; Radionuclide Imaging; Regional Blood Flow; Thromboxane-A Synthase; Vascular Patency | 1991 |
Multiple dose trial of the thromboxane synthase inhibitor furegrelate in normal subjects.
Topics: Adolescent; Adult; Benzofurans; Bleeding Time; Blood Coagulation; Blood Platelets; Half-Life; Humans; Intestinal Absorption; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Random Allocation; Thromboxane-A Synthase; Thromboxanes | 1990 |
101 other study(ies) available for furegrelate and benzofurans
| Article | Year |
|---|---|
Inhibition of cyclooxygenase metabolite production attenuates ischemia-reperfusion lung injury.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Benzofurans; Blood Pressure; Cyclooxygenase Inhibitors; Dinoprost; Flurbiprofen; Hydrogen Peroxide; Indomethacin; Lung; Male; Prostaglandin-Endoperoxide Synthases; Pulmonary Artery; Rats; Rats, Inbred Strains; Reperfusion Injury; Thromboxane B2; Thromboxane-A Synthase | 1991 |
Increased prostacyclin and adverse hemodynamic responses to protamine sulfate in an experimental canine model.
Topics: Animals; Benzofurans; Dogs; Epoprostenol; Hemodynamics; Indomethacin; Nitroprusside; Oxygen; Oxygen Consumption; Platelet Aggregation; Platelet Count; Protamines; Thromboxane-A Synthase; Thromboxanes; Veins | 1991 |
Increased production of ovarian thromboxane in gonadotropin-treated immature rats: relationship to the ovulatory process.
Topics: Animals; Benzofurans; Biphenyl Compounds; Chorionic Gonadotropin; Female; Gonadotropins; Gonadotropins, Equine; Indomethacin; Ovary; Ovulation; Rats; Rats, Inbred Strains; Thromboxane B2; Thromboxanes | 1990 |
C3a57-77, a C-terminal peptide, causes thromboxane-dependent pulmonary vascular constriction in isolated perfused rat lungs.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Benzofurans; Blood Pressure; Complement C3a; Cyclooxygenase Inhibitors; Imidazoles; In Vitro Techniques; Indomethacin; Lung; Male; Peptide Fragments; Perfusion; Pyridines; Rats; Thromboxane B2; Thromboxane-A Synthase; Vasoconstriction | 1990 |
The effect of thromboxane receptor blockade versus thromboxane synthase inhibition on canine arterial graft patency.
Topics: Animals; Aspirin; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Dipyridamole; Dogs; Fatty Acids, Unsaturated; Graft Occlusion, Vascular; Hydrazines; Male; Platelet Aggregation; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2; Thromboxane-A Synthase; Vascular Patency | 1990 |
TxA2 inhibition and ischemia-induced loss of myocardial function and reactive hyperemia.
Topics: Animals; Benzofurans; Coronary Disease; Dogs; Female; Heart; Hyperemia; Male; Myocardial Reperfusion; Myocardium; Peroxidase; Thromboxane A2; Thromboxane-A Synthase | 1990 |
Modulation of experimental cyclosporine nephrotoxicity by inhibition of thromboxane synthesis.
Topics: Animals; Benzofurans; Cyclosporins; Indomethacin; Kidney; Male; Rats; Rats, Inbred Strains; Thromboxane A2; Vasoconstriction | 1990 |
Effect of furegrelate on renal plasma flow after angiotensin II infusion.
Topics: Angiotensin II; Animals; Benzofurans; Blood Pressure; Indomethacin; Infusions, Intravenous; Male; p-Aminohippuric Acid; Rats; Rats, Inbred Strains; Renal Circulation; Thromboxane B2; Thromboxane-A Synthase | 1990 |
Cyclosporine-induced hypertension in sheep. The role of thromboxanes.
Topics: Animals; Benzofurans; Cyclosporins; Dose-Response Relationship, Drug; Female; Glomerular Filtration Rate; Hypertension; Renin; Sheep; Thromboxanes | 1990 |
The effects of a thromboxane synthase inhibitor, a prostacyclin analog and PGE1 on the nephritis of the NZB/W F1 mouse.
Topics: 6-Ketoprostaglandin F1 alpha; Age Factors; Alprostadil; Animals; Benzofurans; Blood Pressure; Disease Models, Animal; Epoprostenol; Female; Iloprost; Lupus Nephritis; Mice; Mice, Inbred NZB; Mice, Inbred Strains; Nephritis; Proteinuria; Thromboxane B2; Vasodilator Agents | 1987 |
Responses of isolated pulmonary arteries to synthetic peptide F-Met-Leu-Phe.
Topics: Animals; Benzofurans; Endothelium, Vascular; Female; In Vitro Techniques; Indomethacin; Male; N-Formylmethionine Leucyl-Phenylalanine; Prostaglandin-Endoperoxide Synthases; Pulmonary Artery; Pyrilamine; Rabbits | 1989 |
Reduced myocardial neutrophil accumulation and infarct size following thromboxane synthetase inhibitor or receptor antagonist.
Topics: Animals; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Chemotaxis, Leukocyte; Creatine Kinase; Epoprostenol; Fatty Acids, Unsaturated; Hydrazines; Male; Myocardial Infarction; Myocardium; Neutrophils; Peroxidase; Platelet Aggregation; Rats; Rats, Inbred Strains; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase | 1989 |
Attenuated coronary relaxation after reperfusion: effects of superoxide dismutase and TxA2 inhibitor U 63557A.
Topics: 6-Ketoprostaglandin F1 alpha; Acetylcholine; Animals; Benzofurans; Blood Platelets; Coronary Vessels; Dogs; Female; Male; Muscle, Smooth, Vascular; Myocardial Reperfusion; Neutrophils; Recombinant Proteins; Reference Values; SRS-A; Superoxide Dismutase; Superoxides; Thromboxane A2; Thromboxane-A Synthase; Vasodilation | 1989 |
Effects of thromboxane synthetase inhibition on patency and anastomotic hyperplasia of vascular grafts.
Topics: Anastomosis, Surgical; Animals; Benzofurans; Blood Vessels; Dogs; Endothelium, Vascular; Epoprostenol; Hyperplasia; Thromboxane-A Synthase; Vascular Patency | 1989 |
Thromboxane synthase activity and platelet function after furegrelate administration in man.
Topics: Adolescent; Adult; Benzofurans; Blood Platelets; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thromboxane-A Synthase | 1989 |
Pharmacokinetics of furegrelate after oral administration to normal humans.
Topics: Administration, Oral; Benzofurans; Dose-Response Relationship, Drug; Humans; Male | 1989 |
Mediators of C5a-induced bronchoconstriction.
Topics: Animals; Benzofurans; Bronchi; Complement C5; Complement C5a; Guinea Pigs; Leukotriene B4; Male; Phenylbutyrates; Thromboxane B2 | 1987 |
Role of arachidonate metabolites in C5a-induced bronchoconstriction.
Topics: Airway Resistance; Animals; Arachidonic Acid; Arachidonic Acids; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Bronchi; Complement C5; Complement C5a; Dinoprost; Fatty Acids, Unsaturated; Guinea Pigs; Hydrazines; Injections, Intravenous; Leukotriene B4; Lung; Prostaglandin D2; Prostaglandins D; Prostaglandins F; Thromboxane B2; Thromboxane-A Synthase | 1988 |
Modulation of human neutrophil superoxide production by selective thromboxane synthetase inhibitor U63,557A.
Topics: Benzofurans; Blood Platelets; Calcimycin; Epoprostenol; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Superoxides; Thromboxane-A Synthase; Zymosan | 1988 |
Platelet-generated thromboxane A2 enhances norepinephrine release from adrenergic nerves.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzofurans; Blood Platelets; In Vitro Techniques; Microsomes; Norepinephrine; Rabbits; Sympathetic Nervous System; Synaptic Transmission; Thromboxane A2 | 1988 |
The protective effect of thromboxane synthetase inhibition on renal function in systemic sepsis.
Topics: Animals; Benzofurans; Glomerular Filtration Rate; Kidney; Natriuresis; Peritonitis; Sheep; Shock, Septic; Thromboxane-A Synthase; Thromboxanes | 1989 |
The effect of thromboxane inhibition on vulnerability to ventricular fibrillation in the acute and chronic feline infarction models.
Topics: Acute Disease; Animals; Benzofurans; Cardiac Pacing, Artificial; Cats; Chronic Disease; Female; Male; Myocardial Infarction; Myocardial Reperfusion; Thromboxane B2; Thromboxane-A Synthase; Ventricular Fibrillation | 1989 |
Effects of antiplatelet agents in combination with endothelial cell seeding on small-diameter Dacron vascular graft performance in the canine carotid artery model.
Topics: Animals; Aspirin; Benzofurans; Blood Platelets; Blood Vessel Prosthesis; Carotid Arteries; Dipyridamole; Dogs; Endothelium; Female; Graft Occlusion, Vascular; Ibuprofen; Male; Polyethylene Terephthalates; Random Allocation; Thrombosis; Thromboxane-A Synthase | 1985 |
In vivo synthesis of thromboxane and prostacyclin in man in health and disease. Data from GC-MS measurements of major urinary metabolites.
Topics: 6-Ketoprostaglandin F1 alpha; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Blood Vessel Prosthesis; Epoprostenol; Gas Chromatography-Mass Spectrometry; Humans; Myocardial Infarction; Thromboxane A2; Thromboxane B2 | 1986 |
Effect of a selective thromboxane synthase inhibitor on arterial graft patency and platelet deposition in dogs.
Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Animals; Arteries; Aspirin; Benzofurans; Blood Platelets; Blood Vessel Prosthesis; Carotid Arteries; Dipyridamole; Dogs; Female; Indium; Polyethylene Terephthalates; Polytetrafluoroethylene; Radioisotopes; Random Allocation; Thromboxane B2; Thromboxane-A Synthase | 1987 |
Thromboxane synthase inhibition and thromboxane/endoperoxide receptor antagonism in a chronic canine model of coronary thrombosis.
Topics: Animals; Benzofurans; Coronary Disease; Coronary Thrombosis; Dibenzothiepins; Dogs; Platelet Aggregation; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane-A Synthase | 1987 |
A pharmacological analysis of the pathophysiological mechanisms of posttraumatic spinal cord ischemia.
Topics: Animals; Benzofurans; Calcium Channel Blockers; Cats; Cyclooxygenase Inhibitors; Diltiazem; Dinoprost; Epoprostenol; Female; Ibuprofen; Ischemia; Male; Meclofenamic Acid; Nifedipine; Prostaglandin Antagonists; Prostaglandins F; Spinal Cord; Thromboxane A2; Verapamil; Vitamin E | 1986 |
Effect of cyclooxygenase and thromboxane synthetase inhibition on furosemide-stimulated plasma renin activity.
Topics: Animals; Benzofurans; Cyclooxygenase Inhibitors; Furosemide; Indomethacin; Male; Rats; Rats, Inbred Strains; Renin; Thromboxane B2; Thromboxane-A Synthase | 1987 |
The association of in vitro arachidonic acid responsiveness and plasma thromboxane levels with early platelet deposition on the luminal surface of small-diameter grafts.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Benzofurans; Blood Vessel Prosthesis; Dogs; Graft Occlusion, Vascular; Platelet Aggregation; Polytetrafluoroethylene; Thromboxane B2; Thromboxane-A Synthase | 1988 |
Influence of eicosanoids on renal function of DOCA-salt hypertensive rats.
Topics: Animals; Benzofurans; Body Water; Bridged Bicyclo Compounds, Heterocyclic; Desoxycorticosterone; Fatty Acids, Unsaturated; Hemodynamics; Hydrazines; Hypertension; Kidney; Male; Meclofenamic Acid; Prostaglandins; Rats; Rats, Inbred Strains; Renal Circulation; Sodium; Sodium Chloride; Thromboxanes | 1988 |
Testing the "redirection hypothesis" of prostaglandin metabolism in the kidney.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Benzofurans; Drug Interactions; Furosemide; Kidney; Male; Prostaglandins; Rats; Rats, Inbred Strains; Renin; Thromboxane B2; Thromboxane-A Synthase | 1987 |
Acute effect of a thromboxane synthetase inhibitor on renal function in unanaesthetized sheep.
Topics: Animals; Benzofurans; Female; Kidney; Renin; Sheep; Sleep; Sodium; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Urodynamics | 1987 |
Thromboxane synthesis inhibitors and postprandial jejunal capillary exchange capacity.
Topics: Animals; Benzofurans; Capillary Permeability; Dogs; Female; Food; Imidazoles; Intestinal Absorption; Jejunum; Male; Mefenamic Acid; Regional Blood Flow; Thromboxane-A Synthase; Venous Pressure | 1988 |
Interaction of platelets with the vessel wall in the pathophysiology of sudden cardiac death.
Topics: Animals; Benzofurans; Blood Platelets; Coronary Disease; Death, Sudden; Dogs; Epoprostenol; Imidazoles; Thromboxane-A Synthase; Ventricular Fibrillation | 1986 |
Beneficial effects of U-63,557A, a thromboxane synthetase inhibitor, in an ovine model of pregnancy-induced hypertension.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Benzofurans; Blood Pressure; Female; Hypertension; Kidney Function Tests; Platelet Count; Pregnancy; Pregnancy Complications, Cardiovascular; Sheep; Thromboxane B2; Thromboxane-A Synthase; Uterus | 1987 |
A high plasma prostaglandin to thromboxane ratio protects against renal ischemia.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Benzofurans; Creatinine; Evaluation Studies as Topic; Ibuprofen; Imidazoles; Ischemia; Kidney; Kidney Tubular Necrosis, Acute; Male; Methacrylates; Pyridines; Rats; Thromboxane B2; Thromboxane-A Synthase | 1987 |
Effect of selective thromboxane synthetase inhibitor on vein grafts.
Topics: Animals; Benzofurans; Blood Vessel Prosthesis; Dogs; Graft Occlusion, Vascular; Iliac Artery; Jugular Veins; Male; Platelet Aggregation; Thromboxane-A Synthase; Vascular Patency | 1987 |
Effect of thromboxane synthetase inhibition on canine autogenous vein grafts.
Topics: Animals; Benzofurans; Blood Platelets; Carotid Arteries; Dogs; Female; Femoral Artery; Graft Occlusion, Vascular; Jugular Veins; Male; Thromboxane B2; Thromboxane-A Synthase; Time Factors; Tissue Preservation; Transplantation, Autologous | 1986 |
Thromboxane A2 synthase inhibitors. 5-(3-Pyridylmethyl)benzofuran-2-carboxylic acids.
Topics: Animals; Benzofurans; Blood Platelets; Dogs; Guinea Pigs; Humans; Imidazoles; Isoenzymes; Lung; Methacrylates; Microsomes; Pyridines; Rabbits; Thromboxane-A Synthase | 1986 |
Protective action of a thromboxane synthetase inhibitor in preventing extension of infarct size in acute myocardial infarction.
Topics: Animals; Benzofurans; Disease Models, Animal; Male; Myocardial Infarction; Oxidoreductases; Rats; Rats, Inbred Strains; Thromboxane A2; Thromboxane-A Synthase | 1985 |
Beneficial effects of acute intravenous ibuprofen on neurologic recovery of head-injured mice: comparison of cyclooxygenase inhibition with inhibition of thromboxane A2 synthetase or 5-lipoxygenase.
Topics: Animals; Arachidonate Lipoxygenases; Benzofurans; Craniocerebral Trauma; Dose-Response Relationship, Drug; Epoprostenol; Ibuprofen; Injections, Intravenous; Lipoxygenase Inhibitors; Mice; Prostaglandin-Endoperoxide Synthases; Thromboxane-A Synthase; Time Factors | 1985 |
Thromboxane synthesis inhibition and postprandial intestinal hyperemia and oxygenation.
Topics: Animals; Benzofurans; Blood Pressure; Dogs; Female; Food; Glucose; Hyperemia; Imidazoles; Injections, Intra-Arterial; Intestinal Absorption; Intestines; Jejunum; Male; Oxygen Consumption; Regional Blood Flow; Thromboxane-A Synthase | 1986 |
Liquid chromatographic-ultraviolet methods for furegrelate in serum and urine: preliminary pharmacokinetic evaluation in the dog.
Topics: Animals; Benzofurans; Capsules; Chromatography, Liquid; Dogs; Female; Injections, Intravenous; Kinetics; Male; Oxidoreductases; Solutions; Spectrophotometry, Ultraviolet; Thromboxane-A Synthase | 1985 |
Effects of thromboxane synthase inhibition on vascular responsiveness in the in vivo rat mesentery.
Topics: Acrylates; Angiotensin II; Animals; Aorta, Abdominal; Benzofurans; Blood Platelets; Blood Pressure; Electric Stimulation; Imidazoles; Methacrylates; Norepinephrine; Rats; Thromboxane B2; Thromboxane-A Synthase; Vascular Resistance | 1985 |
Thromboxane is not responsible for the high pulmonary vascular resistance in fetal lambs.
Topics: Animals; Benzofurans; Chromones; Female; Fetus; Pregnancy; Pulmonary Circulation; Sheep; SRS-A; Thromboxane A2; Thromboxane-A Synthase; Vascular Resistance | 1985 |
Sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylate (U-63557A) potentiates protective effect of intravenous eicosapentaenoic acid on impaired CBF in ischemic gerbils.
Topics: Animals; Benzofurans; Brain Ischemia; Cerebrovascular Circulation; Drug Synergism; Eicosapentaenoic Acid; Fatty Acids, Unsaturated; Gerbillinae; Male | 1984 |
Inhibition of platelet thromboxane A2 synthase activity by sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylate.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzofurans; Blood Platelets; Cyclic AMP; Dogs; Humans; Oxidoreductases; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes | 1983 |
Antithrombogenic effects of calcium channel blockers: synergism with prostacyclin and thromboxane synthase inhibitors.
Topics: Adenosine Diphosphate; Benzofurans; Blood Platelets; Calcium Channel Blockers; Diltiazem; Drug Synergism; Epoprostenol; Humans; Nicotinic Acids; Nifedipine; Nimodipine; Oxidoreductases; Platelet Aggregation; Thrombin; Thromboxane A2; Thromboxane-A Synthase; Verapamil | 1984 |
Beneficial effect of a thromboxane synthetase inhibitor in traumatic shock.
Topics: Animals; Benzofurans; Blood Pressure; Cathepsin D; Dose-Response Relationship, Drug; Lysosomes; Male; Myocardial Depressant Factor; Oxidoreductases; Prognosis; Rats; Rats, Inbred Strains; Shock, Traumatic; Thromboxane B2; Thromboxane-A Synthase | 1984 |
Sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylate (U-63557A), a new, selective thromboxane synthase inhibitor: intravenous and oral pharmacokinetics in dogs and correlations with ex situ thromboxane B2 production.
Topics: Administration, Oral; Animals; Benzofurans; Chromatography, High Pressure Liquid; Dogs; Half-Life; Injections, Intravenous; Kinetics; Oxidoreductases; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes | 1983 |
Sepsis and acute renal failure.
Topics: Acute Kidney Injury; Animals; Aprotinin; Benzofurans; Humans; Kallikrein-Kinin System; Multiple Organ Failure; Sheep; Shock, Septic; Thromboxane-A Synthase | 1994 |
Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. VI. Indazole derivatives.
Topics: Administration, Oral; Aminophylline; Animals; Benzofurans; Bronchodilator Agents; Fatty Acids, Monounsaturated; Guinea Pigs; Histamine Antagonists; In Vitro Techniques; Indazoles; Male; Methacrylates; Pentanoic Acids; Pyridines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thromboxane-A Synthase; Trachea | 1995 |
Acquired essential fatty acid depletion in the remnant kidney: amelioration with U-63557A.
Topics: Animals; Benzofurans; Dinoprostone; Fatty Acids; Fatty Acids, Essential; Kidney; Kidney Cortex; Male; Models, Biological; Nephrectomy; Rats; Rats, Sprague-Dawley; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Time Factors | 1994 |
A renal vasodilator effect of angiotensin II revealed by dual thromboxane inhibition.
Topics: Angiotensin II; Animals; Benzofurans; Blood Pressure; Rats; Rats, Sprague-Dawley; Renal Circulation; Thromboxane-A Synthase; Thromboxanes; Vascular Resistance; Vasodilation | 1994 |
Cyclooxygenase and lipoxygenase inhibition by BW-755C reduces acrolein smoke-induced acute lung injury.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acrolein; Animals; Benzofurans; Blood Proteins; Cyclooxygenase Inhibitors; Eicosanoids; Indomethacin; Inflammation Mediators; Lipoxygenase Inhibitors; Lymph; Oxygen Consumption; Pulmonary Circulation; Sheep; Smoke Inhalation Injury; Thromboxane-A Synthase; Vascular Resistance | 1994 |
Thromboxane synthase inhibition enhances furosemide-induced renal vasodilation.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Benzofurans; Diuresis; Drug Interactions; Furosemide; Indomethacin; Kidney; Male; p-Aminohippuric Acid; Rats; Rats, Sprague-Dawley; Thromboxane-A Synthase; Vasodilation | 1993 |
Long-term renal preservation and prevention of acute tubular necrosis by inhibition of arachidonate metabolism.
Topics: Animals; Arachidonic Acids; Benzofurans; Dogs; Female; Imidazoles; Kidney Transplantation; Kidney Tubular Necrosis, Acute; Organ Preservation; Pyridines; Thromboxane-A Synthase | 1993 |
Prolonged kidney preservation by inhibition of arachidonic acid metabolism.
Topics: Animals; Arachidonic Acids; Aspirin; Benzofurans; Creatinine; Diethylcarbamazine; Dogs; Female; Graft Survival; Kidney; Kidney Transplantation; Organ Preservation; Perfusion; Time Factors; Transplantation, Autologous; Transplantation, Heterologous | 1993 |
Five-to-seven-day kidney preservation with aspirin and furegrelate.
Topics: Animals; Aspirin; Benzofurans; Creatinine; Dogs; Female; Kidney; Kidney Transplantation; Organ Preservation; Prostaglandin Antagonists; Prostaglandins; Thromboxane-A Synthase; Thromboxanes; Time Factors | 1993 |
Effect of new thromboxane A2 synthesis inhibitor tetramethyl-pyrazine on pancreatic transplantation in diabetic rats.
Topics: Albuminuria; Animals; Benzofurans; beta 2-Microglobulin; Cyclosporine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Enzyme Inhibitors; Immunosuppressive Agents; Kidney; Organ Size; Pancreas Transplantation; Pyrazines; Rats; Rats, Wistar; Thromboxane A2; Thromboxane-A Synthase; Transplantation, Isogeneic | 1996 |
Arginine vasopressin interacts with thromboxane in hydronephrosis.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Arterioles; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydrazines; Hydronephrosis; In Vitro Techniques; Male; Rats; Rats, Sprague-Dawley; Reference Values; Renal Circulation; Thromboxane-A Synthase; Thromboxanes; Vasoconstriction | 1997 |
Long-term renal preservation and prevention of acute tubular necrosis by inhibition of arachidonate metabolism.
Topics: Adenosine; Allopurinol; Animals; Arachidonic Acid; Aspirin; Benzofurans; Dogs; Enzyme Inhibitors; Female; Glutathione; Ibuprofen; Imidazoles; Insulin; Kidney Transplantation; Kidney Tubular Necrosis, Acute; Kidney Tubules; Leukotriene Antagonists; Leukotrienes; Organ Preservation; Organ Preservation Solutions; Pyridines; Raffinose; Thromboxane-A Synthase | 1995 |
Inhibition of thromboxane synthesis attenuates insulin hypertension in rats.
Topics: Animals; Benzofurans; Glomerular Filtration Rate; Hyperinsulinism; Hypertension; Male; Potassium; Rats; Rats, Sprague-Dawley; Sodium; Thromboxane-A Synthase; Thromboxanes | 1997 |
Changes in glomerular thromboxane A2 receptor expression and ligand binding following immune injury.
Topics: Animals; Benzofurans; Disease Models, Animal; Enzyme Inhibitors; Glomerular Filtration Rate; Glomerulonephritis; Kidney Glomerulus; Kinetics; Ligands; Male; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Thromboxane A2; Thromboxane-A Synthase | 1999 |
Thromboxane A(2) regulation of endothelial cell migration, angiogenesis, and tumor metastasis.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Chemotaxis; Dinoprost; Dinoprostone; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Epoprostenol; Fatty Acids, Unsaturated; Fibroblast Growth Factor 2; Humans; Hydrazines; Lung Neoplasms; Lymphokines; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neovascularization, Pathologic; Rats; Receptors, Thromboxane; Thromboxane A2; Thromboxane-A Synthase; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Perfusion of the hypothalamic paraventricular nucleus with N-methyl-D-aspartate produces thromboxane A2 and centrally activates adrenomedullary outflow in rats.
Topics: Adrenal Medulla; Animals; Benzofurans; Catecholamines; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; N-Methylaspartate; Paraventricular Hypothalamic Nucleus; Perfusion; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase | 2000 |
Eicosapentaenoic acid suppresses PDGF-induced DNA synthesis in rat mesangial cells: involvement of thromboxane A2.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Benzofurans; Cell Count; Cell Division; Cells, Cultured; Culture Media; DNA; Eicosapentaenoic Acid; Enzyme Inhibitors; Glomerular Mesangium; Indomethacin; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley; Thromboxane A2; Thymidine | 2000 |
Shear stress-induced release of prostaglandin H(2) in arterioles of hypertensive rats.
Topics: Animals; Arterioles; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydrazines; Hypertension; Prostaglandin H2; Prostaglandins H; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Prostaglandin; Receptors, Thromboxane A2, Prostaglandin H2; Stress, Mechanical; Thromboxane-A Synthase | 2000 |
Effects of cyclo-oxygenase and thromboxane synthetase inhibitors on right atrial prostaglandins.
Topics: Aspirin; Benzofurans; Coronary Artery Bypass; Coronary Disease; Culture Techniques; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Heart Atria; Humans; Indomethacin; Prostaglandins; Thromboxane A2; Thromboxane-A Synthase | 2000 |
Effects of selective cyclooxygenase-2 inhibition on vascular responses and thrombosis in canine coronary arteries.
Topics: Acetylcholine; Animals; Arachidonic Acid; Aspirin; Benzofurans; Blood Flow Velocity; Celecoxib; Coronary Circulation; Coronary Thrombosis; Coronary Vessels; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Epoprostenol; Isoenzymes; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Thromboxane-A Synthase; Time Factors; Vasodilation; Vasomotor System | 2001 |
Thromboxane synthase regulates the migratory phenotype of human glioma cells.
Topics: Arachidonic Acids; Aspirin; Astrocytes; Benzofurans; Brain Neoplasms; Cell Adhesion; Cell Movement; Enzyme Induction; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; GTP-Binding Proteins; Humans; Imidazoles; Indomethacin; Lysine; Models, Biological; Neoplasm Proteins; Neoplastic Stem Cells; Oligodendroglia; Pentanoic Acids; Phenotype; Pyridines; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Thromboxane B2; Thromboxane-A Synthase; Tumor Cells, Cultured | 1999 |
Indomethacin protects permeability barrier from focal segmental glomerulosclerosis serum.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Albumins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Benzofurans; Cell Membrane Permeability; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Enzyme Inhibitors; Glomerulosclerosis, Focal Segmental; Indomethacin; Kidney Glomerulus; Male; Proteinuria; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents | 2002 |
Angiotensin II constriction of rat vasa recta is partially thromboxane dependent.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 5,8,11,14-Eicosatetraynoic Acid; Angiotensin II; Animals; Benzofurans; Blood Vessels; Bridged Bicyclo Compounds, Heterocyclic; Culture Techniques; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Fatty Acids, Unsaturated; Female; Hydrazines; Indomethacin; Kidney Medulla; Kinetics; Lipoxygenase Inhibitors; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Thromboxane-A Synthase; Thromboxanes; Vasoconstriction; Vasoconstrictor Agents | 2002 |
Role of brain thromboxane A2 in the release of noradrenaline and adrenaline from adrenal medulla in rats.
Topics: Adrenal Medulla; Adrenalectomy; Animals; Arachidonic Acid; Benzofurans; Brain; Corticotropin-Releasing Hormone; Epinephrine; Injections, Intraventricular; Male; Norepinephrine; Rats; Rats, Wistar; Thromboxane A2; Vasopressins | 2003 |
Inhibition of prostaglandin D2 clearance in rat hepatocytes by the thromboxane receptor antagonists daltroban and ifetroban and the thromboxane synthase inhibitor furegrelate.
Topics: Animals; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Complement C5a; Enzyme Inhibitors; Hepatocytes; Liver; Male; Metabolic Clearance Rate; Oxazoles; Perfusion; Phenylacetates; Prostaglandin D2; Rats; Rats, Wistar; Receptors, Thromboxane; Sulfonamides; Thromboxane B2; Thromboxane-A Synthase | 2003 |
Inhibition of the arachidonic acid metabolism blocks endothelial cell migration and induces apoptosis.
Topics: Apoptosis; Arachidonic Acid; Aspirin; Benzofurans; Cell Culture Techniques; Cell Line, Tumor; Cell Movement; Cyclooxygenase Inhibitors; Endothelial Cells; Humans; Imidazoles; Neuroglia; Thromboxane-A Synthase | 2004 |
Thromboxane A2 from Kupffer cells contributes to the hyperresponsiveness of hepatic portal circulation to endothelin-1 in endotoxemic rats.
Topics: Animals; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Endothelin-1; Endotoxemia; Fatty Acids, Unsaturated; Gadolinium; Hydrazines; Kupffer Cells; Lipopolysaccharides; Liver; Male; Portal Pressure; Portal System; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Thromboxane A2; Thromboxane-A Synthase | 2005 |
Testosterone treatment increases thromboxane function in rat cerebral arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Androgens; Animals; Benzofurans; Body Weight; Bridged Bicyclo Compounds, Heterocyclic; Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydrazines; Male; Middle Cerebral Artery; Orchiectomy; Rats; Rats, Inbred F344; Receptors, Thromboxane; Testosterone; Thromboxane A2; Thromboxane-A Synthase; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2005 |
Brain prostanoid TP receptor-mediated adrenal noradrenaline secretion and EP3 receptor-mediated sympathetic noradrenaline release in rats.
Topics: Adrenal Glands; Adrenalectomy; Animals; Benzofurans; Bombesin; Brain; Bridged Bicyclo Compounds; Dinoprostone; Fatty Acids, Monounsaturated; Injections, Intraventricular; Male; Norepinephrine; Rats; Rats, Wistar; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP3 Subtype; Receptors, Thromboxane; Sympathetic Nervous System; Thromboxane-A Synthase | 2005 |
Gender difference in response to thromboxane A2/prostaglandin H2 receptor antagonism in spontaneously hypertensive rats.
Topics: Analysis of Variance; Animals; Benzofurans; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Female; Hemodynamics; Hydrazines; Male; Rats; Rats, Inbred SHR; Sex Factors; Thromboxane-A Synthase | 2004 |
Involvement of brain thromboxane A in hypotension induced by haemorrhage in rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzofurans; Blood Pressure; Disease Models, Animal; Epinephrine; Heart Rate; Hemorrhage; Hypotension; Hypothalamus; Injections, Intraventricular; Male; Rats; Rats, Sprague-Dawley; Thromboxane A2; Thromboxane-A Synthase; Time Factors; Vasoconstrictor Agents; Vasopressins | 2005 |
The role of the central thromboxane A2 in cardiovascular effects of a phospholipase A2 activator melittin administrated intracerebroventricularly in normotensive conscious rats.
Topics: Animals; Benzofurans; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fatty Acids, Unsaturated; Heart Rate; Hydrazines; Male; Melitten; Phospholipases A; Phospholipases A2; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane A2 | 2006 |
Centrally administered histamine evokes the adrenal secretion of noradrenaline and adrenaline by brain cyclooxygenase-1- and thromboxane A2-mediated mechanisms in rats.
Topics: Adrenal Medulla; Adrenalectomy; Animals; Benzofurans; Brain; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epinephrine; Histamine; Histamine Agents; Injections, Intraventricular; Ketoprofen; Male; Nitrobenzenes; Norepinephrine; Rats; Rats, Wistar; Sulfonamides; Thromboxane A2 | 2006 |
Adrenal adrenaline- and noradrenaline-containing cells and celiac sympathetic ganglia are differentially controlled by centrally administered corticotropin-releasing factor and arginine-vasopressin in rats.
Topics: Adrenal Medulla; Animals; Arachidonic Acid; Arginine Vasopressin; Benzofurans; Brain; Corticotropin-Releasing Hormone; Epinephrine; Ganglia, Sympathetic; Gene Expression; Genes, fos; Indomethacin; Injections, Intraventricular; Male; Norepinephrine; Photomicrography; Prostaglandins; Rats; Rats, Wistar; Thromboxane A2 | 2007 |
A change in the redox environment and thromboxane A2 production precede endothelial dysfunction in mice.
Topics: Acetylcholine; Acetylcysteine; Aging; Animals; Antioxidants; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Catechin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Fatty Acids, Unsaturated; Gene Expression Regulation, Enzymologic; Hydrazines; Indomethacin; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroarginine; Oxidation-Reduction; Reactive Oxygen Species; Receptors, Thromboxane A2, Prostaglandin H2; Renal Artery; RNA, Messenger; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Vasodilator Agents | 2007 |
Involvement of COX-1 in A3 adenosine receptor-mediated contraction through endothelium in mice aorta.
Topics: Adenosine; Animals; Aorta; Benzofurans; Blotting, Western; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelium, Vascular; Indomethacin; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Knockout; Nitrobenzenes; Polymerase Chain Reaction; Pyrazoles; Pyridines; Receptor, Adenosine A3; Receptors, Thromboxane; RNA, Messenger; Signal Transduction; Sulfonamides; Thromboxane B2; Thromboxane-A Synthase; Vasoconstriction; Vasoconstrictor Agents | 2007 |
Orchidectomy increases the formation of non-endothelial thromboxane A2 and modulates its role in the electrical field stimulation-induced response in rat mesenteric artery.
Topics: Animals; Benzofurans; Body Weight; Electric Stimulation; Epoprostenol; Male; Mesenteric Arteries; Nitric Oxide; Norepinephrine; Orchiectomy; Rats; Rats, Sprague-Dawley; Testosterone; Thromboxane A2; Thromboxane-A Synthase | 2008 |
Centrally administered neuromedin U elevates plasma adrenaline by brain prostanoid TP receptor-mediated mechanisms in rats.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Brain Chemistry; Bridged Bicyclo Compounds; Catecholamines; Enzyme Inhibitors; Epinephrine; Fatty Acids, Monounsaturated; Indomethacin; Injections, Intraventricular; Male; Neuropeptides; Prostaglandin Antagonists; Rats; Rats, Wistar; Receptors, Thromboxane; Thromboxane-A Synthase; Urethane | 2008 |
Hypertension increases contractile responses to hydrogen peroxide in resistance arteries through increased thromboxane A2, Ca2+, and superoxide anion levels.
Topics: Animals; Benzofurans; Calcium; Endothelium, Vascular; Enzyme Inhibitors; Hydrogen Peroxide; Hypertension; Indomethacin; Male; Mesenteric Arteries; Myocardial Contraction; Organic Chemicals; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Superoxides; Thromboxane A2; Thromboxane-A Synthase | 2009 |
Inhibition of invasion-associated thromboxane synthase sensitizes experimental gliomas to gamma-radiation.
Topics: Animals; Animals, Inbred Strains; Astrocytes; Benzofurans; Brain Neoplasms; Cell Survival; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Enzyme Inhibitors; Gamma Rays; Gene Expression Regulation, Neoplastic; Glioma; Humans; Mice; Neoplasm Invasiveness; Radiation Tolerance; Thromboxane-A Synthase; Thromboxanes; Time Factors; Transfection | 2009 |
Role of prostanoid production and receptors in the regulation of retinal endogenous amino acid neurotransmitters by 8-isoprostaglandin E2, ex vivo.
Topics: Animals; Benzofurans; Biphenyl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cyclooxygenase Inhibitors; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Dinoprostone; Fatty Acids, Unsaturated; Flurbiprofen; Glutamic Acid; Glutamine; Glycine; Hydrazines; Isoprostanes; Neurotransmitter Agents; Nitrobenzenes; Prostaglandins; Receptors, Prostaglandin; Retina; Sulfonamides; Xanthones | 2009 |
Ovariectomy increases the formation of prostanoids and modulates their role in acetylcholine-induced relaxation and nitric oxide release in the rat aorta.
Topics: Acetylcholine; Animals; Aorta; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Epoprostenol; Fatty Acids, Unsaturated; Female; Hydrazines; Intramolecular Oxidoreductases; Membrane Proteins; Nitric Oxide; Nitrobenzenes; Ovariectomy; Prostaglandins; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase; Tranylcypromine; Vasodilation; Vasodilator Agents | 2009 |
Central mechanism underlying pressor and bradycardic effect of intracerebroventricularly injected arachidonic acid.
Topics: Animals; Arachidonic Acid; Benzofurans; Blood Pressure; Bradycardia; Bridged Bicyclo Compounds, Heterocyclic; Cardiovascular System; Fatty Acids, Unsaturated; Heart Rate; Hydrazines; Indomethacin; Infusions, Intraventricular; Male; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane A2, Prostaglandin H2; Signal Transduction; Thromboxane A2 | 2011 |
Up-regulation of thromboxane A₂ impairs cerebrovascular eNOS function in aging atherosclerotic mice.
Topics: Acetophenones; Aging; Animals; Antioxidants; Atherosclerosis; Benzofurans; Catechin; Cerebral Arteries; Enzyme Inhibitors; Hemodynamics; Humans; Hydrogen Peroxide; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type III; Oxidants; Oxidative Stress; Receptors, LDL; Thromboxane A2; Thromboxane-A Synthase; Up-Regulation | 2011 |
Kupffer cell depletion attenuates leptin-mediated methoxamine-stimulated portal perfusion pressure and thromboxane A2 release in a rodent model of NASH-cirrhosis.
Topics: Analysis of Variance; Animals; Arachidonic Acid; Benzofurans; Choline; Clodronic Acid; Diet, High-Fat; DNA Primers; Fatty Acids, Unsaturated; Fatty Liver; Gadolinium; Hemodynamics; Hypertension, Portal; Insulin Resistance; Kupffer Cells; Leptin; Methionine; Methoxamine; Microcirculation; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Rats; Receptors, Thromboxane A2, Prostaglandin H2; RNA, Messenger; Sulfonylurea Compounds; Thiobarbituric Acid Reactive Substances; Thromboxane A2 | 2012 |
Thromboxane A2 exerts promoting effects on cell proliferation through mediating cyclooxygenase-2 signal in lung adenocarcinoma cells.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Apoptosis; Benzofurans; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fatty Acids, Unsaturated; Flow Cytometry; Humans; Hydrazines; Immunoenzyme Techniques; Lung Neoplasms; Nitrobenzenes; Real-Time Polymerase Chain Reaction; Receptors, Thromboxane; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sulfonamides; Sulfonylurea Compounds; Thromboxane A2; Thromboxane-A Synthase | 2014 |
Brain thromboxane A2 via arachidonic acid cascade induces the hypothalamic-pituitary-gonadal axis activation in rats.
Topics: Animals; Arachidonic Acid; Benzofurans; Brain; Dose-Response Relationship, Drug; Enzyme Inhibitors; Follicle Stimulating Hormone; Growth Hormone-Releasing Hormone; Ibuprofen; Infusions, Intraventricular; Luteinizing Hormone; Male; Prostaglandin-Endoperoxide Synthases; Rats, Sprague-Dawley; Signal Transduction; Sperm Count; Sperm Motility; Testosterone; Thromboxane A2; Time Factors | 2015 |
The effects of centrally injected arachidonic acid on respiratory system: Involvement of cyclooxygenase to thromboxane signaling pathway.
Topics: Anesthesia; Animals; Arachidonic Acid; Benzofurans; Carbon Dioxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ibuprofen; Injections, Intraventricular; Male; Oxygen; Prostaglandin-Endoperoxide Synthases; Rats, Sprague-Dawley; Respiration; Respiratory System; Respiratory System Agents; Thromboxane A2; Tidal Volume; Time Factors | 2016 |
NO synthase inhibition attenuates EDHF-mediated relaxation induced by TRPV4 channel agonist GSK1016790A in the rat pulmonary artery: Role of TxA2.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Apamin; Benzofurans; Biological Factors; Dioxanes; Dose-Response Relationship, Drug; In Vitro Techniques; Leucine; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Potassium; Pulmonary Artery; Pyrazoles; Rats; Receptors, Thromboxane A2, Prostaglandin H2; Sulfonamides; TRPV Cation Channels; Vasodilation | 2016 |
Thromboxane A
Topics: Adrenal Medulla; Animals; Benzofurans; Blood Glucose; Deoxyglucose; Epinephrine; Indomethacin; Injections, Intraventricular; Male; Neurons; Norepinephrine; Paraventricular Hypothalamic Nucleus; Phentolamine; Rats; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Thromboxane A2 | 2020 |
Comparative study on the effect of aspirin, TP receptor antagonist and TxA
Topics: Arachidonic Acid; Aspirin; Benzofurans; Carbazoles; Enzyme Inhibitors; Female; Humans; Male; Mammary Arteries; Muscle, Smooth, Vascular; Phenylephrine; Receptors, Prostaglandin; Receptors, Thromboxane; Saphenous Vein; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase; Thromboxanes; Vasoconstriction | 2021 |