furegrelate and benzofurans

furegrelate has been researched along with benzofurans in 104 studies

Research

Studies (104)

TimeframeStudies, this research(%)All Research%
pre-199041 (39.42)18.7374
1990's27 (25.96)18.2507
2000's27 (25.96)29.6817
2010's7 (6.73)24.3611
2020's2 (1.92)2.80

Authors

AuthorsStudies
Gray-Weale, A; Huber, D; Joseph, M; Langsfeld, M; Lusby, RJ; Meyer, JH; Payne, JE; Smith, T1
Bolling, SF; Deeb, GM; Grum, CM; Ljungman, AG; Morganroth, ML1
Stanley, JC; Wakefield, TW; Wang, TW; Wirthlin, DJ; Wrobleski, SK1
Ji, TH; Murdoch, WJ; Slaughter, RG; Van Kirk, EA; Wilken, C1
Glovsky, MM; Horvath, SJ; Morganroth, ML; Schoeneich, SO; Till, GO; Ward, PA1
Bech, FR; Cronenwett, JL; Freeman, DH; McDaniel, MD; Ogletree, ML1
Chandna, VK; Donnelly, WH; Mehta, JL; Nichols, WW; Schofield, R1
Freeman, D; Keown, P; McDonald, J; Petric, R; Stiller, C; Wallace, C1
Kaushal, RD; Wilson, TW1
Lakings, DB; Mohrland, JS; Vander Lugt, JT1
Bennett, WM; Scoggins, BA; Tresham, JJ; Whitworth, JA1
Clark, WF; Kreeft, J; McDonald, JW; Parbtani, A; Reid, BD; Taylor, N1
Crowell, RE; Reed, WP; Van Epps, DE1
Franzini, D; Lawson, D; Mehta, J; Nichols, WW; Wargovich, TJ1
Lawson, DL; Mehta, JL; Nichols, WW1
Brothers, TE; Burkel, WE; Darvishian, D; Graham, LM; Harrell, KA; Stanley, JC; Vincent, CK1
Gorman, RR; Lakings, DB; Mohrland, JS; Vander Lugt, JT1
Friis, JM; Lakings, DB; Lunan, CM; Mohrland, JS; VanderLugt, JT1
Regal, JF2
Lawson, D; Mehta, JL; Mehta, P1
Stein, E; Trachte, GJ1
Cumming, AD; Lindsay, RM; Linton, AL; McDonald, JW; Solez, K1
Friehling, TD; Kowey, PR; O'Connor, KM1
Evancho, MM; Falkow, LJ; Hunter, TJ; Schmidt, SP; Sharp, WV1
Gréen, K; Vesterqvist, O1
Cronenwett, JL; Huntsman, WT; McDaniel, MD; Miett, TO1
Fenelon, LC; Fitzgerald, DJ; FitzGerald, GA; Fragetta, J1
Hall, ED; Wolf, DL1
Datar, S; McCauley, FA; Wilson, TW2
Anderson, CB; Freeman, MB; Mangino, MJ; Neuberger, S; Sicard, GA; Valentin, LI1
Kaldunski, ML; Mattson, DL; Mistry, M; Nasjletti, A; Roman, RJ1
Cumming, AD; Lindsay, RM; Linton, AL; McDonald, JW1
Chou, CC; Mangino, MJ2
Hammon, JW; Oates, JA1
Keith, JC; Schaub, RG; Thatcher, CD1
Anner, H; Hechtman, HB; Kaufman, RP; Kobzik, L; Shepro, D; Valeri, CR1
Askins, R; Cargile, M; Hebeler, RF; Neyman, SL; O'Leary, JP1
Boorstein, JM; Cronenwett, JL; Endean, ED; Hees, PL1
Aiken, JW; Crittenden, NJ; Gorman, RR; Johnson, RA; Nidy, EG1
Hock, CE; Lefer, AM; Phillips, GR1
Hall, ED1
Friis, JM; Lakings, DB1
Jackson, EK1
Clozel, M; Clyman, RI; Heymann, MA; Soifer, SJ1
Black, KL; Hoff, JT; Hsu, S; Radin, NS1
Aiken, JW; Gorman, RR; Johnson, RA; Spilman, CH1
Honn, KV; Onoda, JM; Sloane, BF1
Hock, CE; Lefer, AM1
Fitzpatrick, FA; Liggett, WF; Wynalda, MA1
Cumming, AD2
Akima, M; Hamana, M; Kamei, K; Koga, T; Kuroki, T; Maruyama, N; Ohi, N; Yamaguchi, M1
Krupa, SM; Lane, PH; Reddington, JC; Salinas-Madrigal, L; Schmitz, PG1
Badahman, AH; Wilson, TW1
Hales, CA; Hutchison, WG; Janssens, SP; Jung, W; Musto, SW; Spence, C; Witten, M1
Badahman, AH; Kaushal, RD; Wilson, TW1
Belzer, FO; Saunder, A; Schilling, M; Southard, JH3
Ametani, M; Belzer, FO; Saunder, A; Schilling, M; Southard, JH1
Chen, S; Li, JW; Ma, SX; Wang, Y; Yan, YH1
Forster, H; Takenaka, T1
Brands, MW; Hall, JE; Keen, HL; Shek, EW; Smith, MJ1
Bresnahan, BA; Dufek, S; Lianos, EA; Wu, S1
Chen, Y; Honn, KV; Lamberti, M; Li, L; Nie, D; Szekeres, K; Tang, K; Zacharek, A1
Murakami, Y; Nishihara, M; Okada, S; Osumi, Y; Yokotani, K1
Dalal, R; Schmitz, PG; Zhang, K1
Huang, A; Koller, A; Sun, D1
Madan, ZM; Sainani, GS1
Barrett, TD; Crofford, LJ; Driscoll, EM; Hennan, JK; Huang, J; Lucchesi, BR; Park, AM; Willens, DE1
Berens, ME; Djawaheri, J; Giese, A; Hagel, C; Kim, EL; Westphal, M; Zapf, S1
McCarthy, ET; Sharma, M1
Hilbun, LR; Pallone, TL; Silldorff, EP1
Murakami, Y; Okada, S; Yokotani, K1
Jungermann, K; Nath, A; Pestel, S; Schieferdecker, HL1
Giese, A; Jantke, J; Kim, E; Kürzel, F; Ladehoff, M; Zapf, S1
Clemens, MG; Karaa, A; Korneszczuk, K; Lin, T; Xu, H; Zhang, JX1
Duckles, SP; Ghaffari, AA; Gonzales, RJ; Krause, DN1
Arai, J; Nakamura, K; Okada, S; Shimizu, T; Wakiguchi, H; Yamaguchi-Shima, N; Yokotani, K1
Acosta Cazal, MC; Fortepiani, LA; Reckelhoff, JF; Santacruz, F1
Cavun, S; Cengiz, F; Savci, V; Yalcin, M; Yilmaz, MS1
Ak, F; Erturk, M; Yalcin, M1
Lu, L; Okada, S; Sasaki, T; Shimizu, T; Yamaguchi, N; Yokotani, K1
Lu, L; Nakamura, K; Okada, S; Shimizu, T; Usui, D; Yamaguchi-Shima, N; Yokotani, K1
Gendron, ME; Thorin, E1
Ansari, HR; Mustafa, SJ; Nadeem, A; Tilley, SL1
Aras-López, R; Balfagón, G; del Campo, L; Ferrer, M; Sagredo, A1
Sasaki, T; Shimizu, T; Wakiguchi, H; Yokotani, K1
Alonso, MJ; Beltrán, AE; Briones, AM; García-Redondo, AB; Salaices, M; Simonsen, U1
Brockmann, MA; Giese, A; Kim, EL; Leppert, J; Nadrowitz, R; Schauff, AK; Wuestenberg, R1
Destache, CJ; Ohia, SE; Opere, CA; Zhao, M1
Aras-López, R; Balfagón, G; Ferrer, M; Martorell, A; Sagredo, A1
Yalcin, M1
Bolduc, V; Drouin, A; Farhat, N; Gillis, MA; Nguyen, A; Thorin, E; Thorin-Trescases, N; Villeneuve, L1
Hou, MC; Huang, YT; Lee, FY; Lee, SD; Lin, HC; Tsai, TH; Yang, YY1
Chen, GG; Guo, HZ; Huang, RY; Huang, Y; Li, MY; Li, SS; Zeng, X; Zhang, X1
Alcay, S; Altinbas, B; Erkan, LG; Guvenc, G; Toker, MB; Udum Kucuksen, D; Ustuner, B; Yalcin, M1
Altinbas, B; Erkan, LG; Guvenc, G; Niaz, N; Yalcin, M1
Addison, MP; Choudhury, S; Darzi, SA; Kandasamy, K; Kasa, JK; Kumar, D; Mishra, SK; Parida, S; Singh, TU; Singh, V; Sukumaran, SV1
Okada, S; Tachi, M; Yamaguchi, N1
Abdelazeem, H; Aljesri, K; Norel, X; Ozen, G; Topal, G; Turkyılmaz, G; Turkyılmaz, S1

Reviews

1 review(s) available for furegrelate and benzofurans

ArticleYear
Acute renal failure and sepsis: therapeutic approaches.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1994, Volume: 9 Suppl 4

    Topics: Acute Kidney Injury; Animals; Aprotinin; Benzofurans; Glomerular Filtration Rate; Humans; Kallikrein-Kinin System; Natriuresis; Peritonitis; Sepsis; Sheep; Thromboxane-A Synthase

1994

Trials

2 trial(s) available for furegrelate and benzofurans

ArticleYear
Effects of Furegrelate (Upjohn 63557A) on patency and platelet deposition after canine carotid endarterectomy.
    The Australian and New Zealand journal of surgery, 1991, Volume: 61, Issue:8

    Topics: Animals; Benzofurans; Carotid Arteries; Carotid Artery Thrombosis; Constriction; Dogs; Endarterectomy; Indium Radioisotopes; Male; Platelet Adhesiveness; Platelet Aggregation; Prospective Studies; Radionuclide Imaging; Regional Blood Flow; Thromboxane-A Synthase; Vascular Patency

1991
Multiple dose trial of the thromboxane synthase inhibitor furegrelate in normal subjects.
    European journal of clinical pharmacology, 1990, Volume: 38, Issue:5

    Topics: Adolescent; Adult; Benzofurans; Bleeding Time; Blood Coagulation; Blood Platelets; Half-Life; Humans; Intestinal Absorption; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Random Allocation; Thromboxane-A Synthase; Thromboxanes

1990

Other Studies

101 other study(ies) available for furegrelate and benzofurans

ArticleYear
Inhibition of cyclooxygenase metabolite production attenuates ischemia-reperfusion lung injury.
    The American review of respiratory disease, 1991, Volume: 143, Issue:3

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Benzofurans; Blood Pressure; Cyclooxygenase Inhibitors; Dinoprost; Flurbiprofen; Hydrogen Peroxide; Indomethacin; Lung; Male; Prostaglandin-Endoperoxide Synthases; Pulmonary Artery; Rats; Rats, Inbred Strains; Reperfusion Injury; Thromboxane B2; Thromboxane-A Synthase

1991
Increased prostacyclin and adverse hemodynamic responses to protamine sulfate in an experimental canine model.
    The Journal of surgical research, 1991, Volume: 50, Issue:5

    Topics: Animals; Benzofurans; Dogs; Epoprostenol; Hemodynamics; Indomethacin; Nitroprusside; Oxygen; Oxygen Consumption; Platelet Aggregation; Platelet Count; Protamines; Thromboxane-A Synthase; Thromboxanes; Veins

1991
Increased production of ovarian thromboxane in gonadotropin-treated immature rats: relationship to the ovulatory process.
    Prostaglandins, 1990, Volume: 40, Issue:6

    Topics: Animals; Benzofurans; Biphenyl Compounds; Chorionic Gonadotropin; Female; Gonadotropins; Gonadotropins, Equine; Indomethacin; Ovary; Ovulation; Rats; Rats, Inbred Strains; Thromboxane B2; Thromboxanes

1990
C3a57-77, a C-terminal peptide, causes thromboxane-dependent pulmonary vascular constriction in isolated perfused rat lungs.
    The American review of respiratory disease, 1990, Volume: 141, Issue:2

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Benzofurans; Blood Pressure; Complement C3a; Cyclooxygenase Inhibitors; Imidazoles; In Vitro Techniques; Indomethacin; Lung; Male; Peptide Fragments; Perfusion; Pyridines; Rats; Thromboxane B2; Thromboxane-A Synthase; Vasoconstriction

1990
The effect of thromboxane receptor blockade versus thromboxane synthase inhibition on canine arterial graft patency.
    Journal of vascular surgery, 1990, Volume: 12, Issue:2

    Topics: Animals; Aspirin; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Dipyridamole; Dogs; Fatty Acids, Unsaturated; Graft Occlusion, Vascular; Hydrazines; Male; Platelet Aggregation; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2; Thromboxane-A Synthase; Vascular Patency

1990
TxA2 inhibition and ischemia-induced loss of myocardial function and reactive hyperemia.
    The American journal of physiology, 1990, Volume: 258, Issue:5 Pt 2

    Topics: Animals; Benzofurans; Coronary Disease; Dogs; Female; Heart; Hyperemia; Male; Myocardial Reperfusion; Myocardium; Peroxidase; Thromboxane A2; Thromboxane-A Synthase

1990
Modulation of experimental cyclosporine nephrotoxicity by inhibition of thromboxane synthesis.
    Transplantation, 1990, Volume: 50, Issue:4

    Topics: Animals; Benzofurans; Cyclosporins; Indomethacin; Kidney; Male; Rats; Rats, Inbred Strains; Thromboxane A2; Vasoconstriction

1990
Effect of furegrelate on renal plasma flow after angiotensin II infusion.
    Canadian journal of physiology and pharmacology, 1990, Volume: 68, Issue:4

    Topics: Angiotensin II; Animals; Benzofurans; Blood Pressure; Indomethacin; Infusions, Intravenous; Male; p-Aminohippuric Acid; Rats; Rats, Inbred Strains; Renal Circulation; Thromboxane B2; Thromboxane-A Synthase

1990
Cyclosporine-induced hypertension in sheep. The role of thromboxanes.
    Transplantation, 1990, Volume: 49, Issue:1

    Topics: Animals; Benzofurans; Cyclosporins; Dose-Response Relationship, Drug; Female; Glomerular Filtration Rate; Hypertension; Renin; Sheep; Thromboxanes

1990
The effects of a thromboxane synthase inhibitor, a prostacyclin analog and PGE1 on the nephritis of the NZB/W F1 mouse.
    Clinical nephrology, 1987, Volume: 28, Issue:6

    Topics: 6-Ketoprostaglandin F1 alpha; Age Factors; Alprostadil; Animals; Benzofurans; Blood Pressure; Disease Models, Animal; Epoprostenol; Female; Iloprost; Lupus Nephritis; Mice; Mice, Inbred NZB; Mice, Inbred Strains; Nephritis; Proteinuria; Thromboxane B2; Vasodilator Agents

1987
Responses of isolated pulmonary arteries to synthetic peptide F-Met-Leu-Phe.
    The American journal of physiology, 1989, Volume: 257, Issue:1 Pt 2

    Topics: Animals; Benzofurans; Endothelium, Vascular; Female; In Vitro Techniques; Indomethacin; Male; N-Formylmethionine Leucyl-Phenylalanine; Prostaglandin-Endoperoxide Synthases; Pulmonary Artery; Pyrilamine; Rabbits

1989
Reduced myocardial neutrophil accumulation and infarct size following thromboxane synthetase inhibitor or receptor antagonist.
    Angiology, 1989, Volume: 40, Issue:3

    Topics: Animals; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Chemotaxis, Leukocyte; Creatine Kinase; Epoprostenol; Fatty Acids, Unsaturated; Hydrazines; Male; Myocardial Infarction; Myocardium; Neutrophils; Peroxidase; Platelet Aggregation; Rats; Rats, Inbred Strains; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase

1989
Attenuated coronary relaxation after reperfusion: effects of superoxide dismutase and TxA2 inhibitor U 63557A.
    The American journal of physiology, 1989, Volume: 257, Issue:4 Pt 2

    Topics: 6-Ketoprostaglandin F1 alpha; Acetylcholine; Animals; Benzofurans; Blood Platelets; Coronary Vessels; Dogs; Female; Male; Muscle, Smooth, Vascular; Myocardial Reperfusion; Neutrophils; Recombinant Proteins; Reference Values; SRS-A; Superoxide Dismutase; Superoxides; Thromboxane A2; Thromboxane-A Synthase; Vasodilation

1989
Effects of thromboxane synthetase inhibition on patency and anastomotic hyperplasia of vascular grafts.
    The Journal of surgical research, 1989, Volume: 46, Issue:6

    Topics: Anastomosis, Surgical; Animals; Benzofurans; Blood Vessels; Dogs; Endothelium, Vascular; Epoprostenol; Hyperplasia; Thromboxane-A Synthase; Vascular Patency

1989
Thromboxane synthase activity and platelet function after furegrelate administration in man.
    Journal of clinical pharmacology, 1989, Volume: 29, Issue:1

    Topics: Adolescent; Adult; Benzofurans; Blood Platelets; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thromboxane-A Synthase

1989
Pharmacokinetics of furegrelate after oral administration to normal humans.
    Pharmaceutical research, 1989, Volume: 6, Issue:1

    Topics: Administration, Oral; Benzofurans; Dose-Response Relationship, Drug; Humans; Male

1989
Mediators of C5a-induced bronchoconstriction.
    Agents and actions, 1987, Volume: 21, Issue:3-4

    Topics: Animals; Benzofurans; Bronchi; Complement C5; Complement C5a; Guinea Pigs; Leukotriene B4; Male; Phenylbutyrates; Thromboxane B2

1987
Role of arachidonate metabolites in C5a-induced bronchoconstriction.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:2

    Topics: Airway Resistance; Animals; Arachidonic Acid; Arachidonic Acids; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Bronchi; Complement C5; Complement C5a; Dinoprost; Fatty Acids, Unsaturated; Guinea Pigs; Hydrazines; Injections, Intravenous; Leukotriene B4; Lung; Prostaglandin D2; Prostaglandins D; Prostaglandins F; Thromboxane B2; Thromboxane-A Synthase

1988
Modulation of human neutrophil superoxide production by selective thromboxane synthetase inhibitor U63,557A.
    Life sciences, 1988, Volume: 43, Issue:11

    Topics: Benzofurans; Blood Platelets; Calcimycin; Epoprostenol; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Superoxides; Thromboxane-A Synthase; Zymosan

1988
Platelet-generated thromboxane A2 enhances norepinephrine release from adrenergic nerves.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:3

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzofurans; Blood Platelets; In Vitro Techniques; Microsomes; Norepinephrine; Rabbits; Sympathetic Nervous System; Synaptic Transmission; Thromboxane A2

1988
The protective effect of thromboxane synthetase inhibition on renal function in systemic sepsis.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1989, Volume: 13, Issue:2

    Topics: Animals; Benzofurans; Glomerular Filtration Rate; Kidney; Natriuresis; Peritonitis; Sheep; Shock, Septic; Thromboxane-A Synthase; Thromboxanes

1989
The effect of thromboxane inhibition on vulnerability to ventricular fibrillation in the acute and chronic feline infarction models.
    American heart journal, 1989, Volume: 117, Issue:4

    Topics: Acute Disease; Animals; Benzofurans; Cardiac Pacing, Artificial; Cats; Chronic Disease; Female; Male; Myocardial Infarction; Myocardial Reperfusion; Thromboxane B2; Thromboxane-A Synthase; Ventricular Fibrillation

1989
Effects of antiplatelet agents in combination with endothelial cell seeding on small-diameter Dacron vascular graft performance in the canine carotid artery model.
    Journal of vascular surgery, 1985, Volume: 2, Issue:6

    Topics: Animals; Aspirin; Benzofurans; Blood Platelets; Blood Vessel Prosthesis; Carotid Arteries; Dipyridamole; Dogs; Endothelium; Female; Graft Occlusion, Vascular; Ibuprofen; Male; Polyethylene Terephthalates; Random Allocation; Thrombosis; Thromboxane-A Synthase

1985
In vivo synthesis of thromboxane and prostacyclin in man in health and disease. Data from GC-MS measurements of major urinary metabolites.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1986, Volume: 16

    Topics: 6-Ketoprostaglandin F1 alpha; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Blood Vessel Prosthesis; Epoprostenol; Gas Chromatography-Mass Spectrometry; Humans; Myocardial Infarction; Thromboxane A2; Thromboxane B2

1986
Effect of a selective thromboxane synthase inhibitor on arterial graft patency and platelet deposition in dogs.
    Archives of surgery (Chicago, Ill. : 1960), 1987, Volume: 122, Issue:8

    Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Animals; Arteries; Aspirin; Benzofurans; Blood Platelets; Blood Vessel Prosthesis; Carotid Arteries; Dipyridamole; Dogs; Female; Indium; Polyethylene Terephthalates; Polytetrafluoroethylene; Radioisotopes; Random Allocation; Thromboxane B2; Thromboxane-A Synthase

1987
Thromboxane synthase inhibition and thromboxane/endoperoxide receptor antagonism in a chronic canine model of coronary thrombosis.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1987, Volume: 17A

    Topics: Animals; Benzofurans; Coronary Disease; Coronary Thrombosis; Dibenzothiepins; Dogs; Platelet Aggregation; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane-A Synthase

1987
A pharmacological analysis of the pathophysiological mechanisms of posttraumatic spinal cord ischemia.
    Journal of neurosurgery, 1986, Volume: 64, Issue:6

    Topics: Animals; Benzofurans; Calcium Channel Blockers; Cats; Cyclooxygenase Inhibitors; Diltiazem; Dinoprost; Epoprostenol; Female; Ibuprofen; Ischemia; Male; Meclofenamic Acid; Nifedipine; Prostaglandin Antagonists; Prostaglandins F; Spinal Cord; Thromboxane A2; Verapamil; Vitamin E

1986
Effect of cyclooxygenase and thromboxane synthetase inhibition on furosemide-stimulated plasma renin activity.
    Canadian journal of physiology and pharmacology, 1987, Volume: 65, Issue:1

    Topics: Animals; Benzofurans; Cyclooxygenase Inhibitors; Furosemide; Indomethacin; Male; Rats; Rats, Inbred Strains; Renin; Thromboxane B2; Thromboxane-A Synthase

1987
The association of in vitro arachidonic acid responsiveness and plasma thromboxane levels with early platelet deposition on the luminal surface of small-diameter grafts.
    Journal of vascular surgery, 1988, Volume: 7, Issue:4

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Benzofurans; Blood Vessel Prosthesis; Dogs; Graft Occlusion, Vascular; Platelet Aggregation; Polytetrafluoroethylene; Thromboxane B2; Thromboxane-A Synthase

1988
Influence of eicosanoids on renal function of DOCA-salt hypertensive rats.
    Hypertension (Dallas, Tex. : 1979), 1988, Volume: 12, Issue:3

    Topics: Animals; Benzofurans; Body Water; Bridged Bicyclo Compounds, Heterocyclic; Desoxycorticosterone; Fatty Acids, Unsaturated; Hemodynamics; Hydrazines; Hypertension; Kidney; Male; Meclofenamic Acid; Prostaglandins; Rats; Rats, Inbred Strains; Renal Circulation; Sodium; Sodium Chloride; Thromboxanes

1988
Testing the "redirection hypothesis" of prostaglandin metabolism in the kidney.
    Prostaglandins, 1987, Volume: 33, Issue:2

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Benzofurans; Drug Interactions; Furosemide; Kidney; Male; Prostaglandins; Rats; Rats, Inbred Strains; Renin; Thromboxane B2; Thromboxane-A Synthase

1987
Acute effect of a thromboxane synthetase inhibitor on renal function in unanaesthetized sheep.
    Clinical science (London, England : 1979), 1987, Volume: 73, Issue:2

    Topics: Animals; Benzofurans; Female; Kidney; Renin; Sheep; Sleep; Sodium; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Urodynamics

1987
Thromboxane synthesis inhibitors and postprandial jejunal capillary exchange capacity.
    The American journal of physiology, 1988, Volume: 254, Issue:5 Pt 1

    Topics: Animals; Benzofurans; Capillary Permeability; Dogs; Female; Food; Imidazoles; Intestinal Absorption; Jejunum; Male; Mefenamic Acid; Regional Blood Flow; Thromboxane-A Synthase; Venous Pressure

1988
Interaction of platelets with the vessel wall in the pathophysiology of sudden cardiac death.
    Circulation, 1986, Volume: 73, Issue:2

    Topics: Animals; Benzofurans; Blood Platelets; Coronary Disease; Death, Sudden; Dogs; Epoprostenol; Imidazoles; Thromboxane-A Synthase; Ventricular Fibrillation

1986
Beneficial effects of U-63,557A, a thromboxane synthetase inhibitor, in an ovine model of pregnancy-induced hypertension.
    American journal of obstetrics and gynecology, 1987, Volume: 157, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Benzofurans; Blood Pressure; Female; Hypertension; Kidney Function Tests; Platelet Count; Pregnancy; Pregnancy Complications, Cardiovascular; Sheep; Thromboxane B2; Thromboxane-A Synthase; Uterus

1987
A high plasma prostaglandin to thromboxane ratio protects against renal ischemia.
    Surgery, gynecology & obstetrics, 1987, Volume: 165, Issue:5

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Benzofurans; Creatinine; Evaluation Studies as Topic; Ibuprofen; Imidazoles; Ischemia; Kidney; Kidney Tubular Necrosis, Acute; Male; Methacrylates; Pyridines; Rats; Thromboxane B2; Thromboxane-A Synthase

1987
Effect of selective thromboxane synthetase inhibitor on vein grafts.
    Southern medical journal, 1987, Volume: 80, Issue:11

    Topics: Animals; Benzofurans; Blood Vessel Prosthesis; Dogs; Graft Occlusion, Vascular; Iliac Artery; Jugular Veins; Male; Platelet Aggregation; Thromboxane-A Synthase; Vascular Patency

1987
Effect of thromboxane synthetase inhibition on canine autogenous vein grafts.
    The Journal of surgical research, 1986, Volume: 40, Issue:4

    Topics: Animals; Benzofurans; Blood Platelets; Carotid Arteries; Dogs; Female; Femoral Artery; Graft Occlusion, Vascular; Jugular Veins; Male; Thromboxane B2; Thromboxane-A Synthase; Time Factors; Tissue Preservation; Transplantation, Autologous

1986
Thromboxane A2 synthase inhibitors. 5-(3-Pyridylmethyl)benzofuran-2-carboxylic acids.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:8

    Topics: Animals; Benzofurans; Blood Platelets; Dogs; Guinea Pigs; Humans; Imidazoles; Isoenzymes; Lung; Methacrylates; Microsomes; Pyridines; Rabbits; Thromboxane-A Synthase

1986
Protective action of a thromboxane synthetase inhibitor in preventing extension of infarct size in acute myocardial infarction.
    Prostaglandins, leukotrienes, and medicine, 1985, Volume: 17, Issue:3

    Topics: Animals; Benzofurans; Disease Models, Animal; Male; Myocardial Infarction; Oxidoreductases; Rats; Rats, Inbred Strains; Thromboxane A2; Thromboxane-A Synthase

1985
Beneficial effects of acute intravenous ibuprofen on neurologic recovery of head-injured mice: comparison of cyclooxygenase inhibition with inhibition of thromboxane A2 synthetase or 5-lipoxygenase.
    Central nervous system trauma : journal of the American Paralysis Association, 1985,Summer, Volume: 2, Issue:2

    Topics: Animals; Arachidonate Lipoxygenases; Benzofurans; Craniocerebral Trauma; Dose-Response Relationship, Drug; Epoprostenol; Ibuprofen; Injections, Intravenous; Lipoxygenase Inhibitors; Mice; Prostaglandin-Endoperoxide Synthases; Thromboxane-A Synthase; Time Factors

1985
Thromboxane synthesis inhibition and postprandial intestinal hyperemia and oxygenation.
    The American journal of physiology, 1986, Volume: 250, Issue:1 Pt 1

    Topics: Animals; Benzofurans; Blood Pressure; Dogs; Female; Food; Glucose; Hyperemia; Imidazoles; Injections, Intra-Arterial; Intestinal Absorption; Intestines; Jejunum; Male; Oxygen Consumption; Regional Blood Flow; Thromboxane-A Synthase

1986
Liquid chromatographic-ultraviolet methods for furegrelate in serum and urine: preliminary pharmacokinetic evaluation in the dog.
    Journal of pharmaceutical sciences, 1985, Volume: 74, Issue:4

    Topics: Animals; Benzofurans; Capsules; Chromatography, Liquid; Dogs; Female; Injections, Intravenous; Kinetics; Male; Oxidoreductases; Solutions; Spectrophotometry, Ultraviolet; Thromboxane-A Synthase

1985
Effects of thromboxane synthase inhibition on vascular responsiveness in the in vivo rat mesentery.
    The Journal of clinical investigation, 1985, Volume: 76, Issue:6

    Topics: Acrylates; Angiotensin II; Animals; Aorta, Abdominal; Benzofurans; Blood Platelets; Blood Pressure; Electric Stimulation; Imidazoles; Methacrylates; Norepinephrine; Rats; Thromboxane B2; Thromboxane-A Synthase; Vascular Resistance

1985
Thromboxane is not responsible for the high pulmonary vascular resistance in fetal lambs.
    Pediatric research, 1985, Volume: 19, Issue:12

    Topics: Animals; Benzofurans; Chromones; Female; Fetus; Pregnancy; Pulmonary Circulation; Sheep; SRS-A; Thromboxane A2; Thromboxane-A Synthase; Vascular Resistance

1985
Sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylate (U-63557A) potentiates protective effect of intravenous eicosapentaenoic acid on impaired CBF in ischemic gerbils.
    Journal of neurosurgery, 1984, Volume: 61, Issue:3

    Topics: Animals; Benzofurans; Brain Ischemia; Cerebrovascular Circulation; Drug Synergism; Eicosapentaenoic Acid; Fatty Acids, Unsaturated; Gerbillinae; Male

1984
Inhibition of platelet thromboxane A2 synthase activity by sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylate.
    Prostaglandins, 1983, Volume: 26, Issue:2

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzofurans; Blood Platelets; Cyclic AMP; Dogs; Humans; Oxidoreductases; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes

1983
Antithrombogenic effects of calcium channel blockers: synergism with prostacyclin and thromboxane synthase inhibitors.
    Thrombosis research, 1984, Jun-01, Volume: 34, Issue:5

    Topics: Adenosine Diphosphate; Benzofurans; Blood Platelets; Calcium Channel Blockers; Diltiazem; Drug Synergism; Epoprostenol; Humans; Nicotinic Acids; Nifedipine; Nimodipine; Oxidoreductases; Platelet Aggregation; Thrombin; Thromboxane A2; Thromboxane-A Synthase; Verapamil

1984
Beneficial effect of a thromboxane synthetase inhibitor in traumatic shock.
    Circulatory shock, 1984, Volume: 14, Issue:3

    Topics: Animals; Benzofurans; Blood Pressure; Cathepsin D; Dose-Response Relationship, Drug; Lysosomes; Male; Myocardial Depressant Factor; Oxidoreductases; Prognosis; Rats; Rats, Inbred Strains; Shock, Traumatic; Thromboxane B2; Thromboxane-A Synthase

1984
Sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylate (U-63557A), a new, selective thromboxane synthase inhibitor: intravenous and oral pharmacokinetics in dogs and correlations with ex situ thromboxane B2 production.
    Prostaglandins, 1983, Volume: 26, Issue:2

    Topics: Administration, Oral; Animals; Benzofurans; Chromatography, High Pressure Liquid; Dogs; Half-Life; Injections, Intravenous; Kinetics; Oxidoreductases; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes

1983
Sepsis and acute renal failure.
    Renal failure, 1994, Volume: 16, Issue:1

    Topics: Acute Kidney Injury; Animals; Aprotinin; Benzofurans; Humans; Kallikrein-Kinin System; Multiple Organ Failure; Sheep; Shock, Septic; Thromboxane-A Synthase

1994
Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. VI. Indazole derivatives.
    Chemical & pharmaceutical bulletin, 1995, Volume: 43, Issue:2

    Topics: Administration, Oral; Aminophylline; Animals; Benzofurans; Bronchodilator Agents; Fatty Acids, Monounsaturated; Guinea Pigs; Histamine Antagonists; In Vitro Techniques; Indazoles; Male; Methacrylates; Pentanoic Acids; Pyridines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thromboxane-A Synthase; Trachea

1995
Acquired essential fatty acid depletion in the remnant kidney: amelioration with U-63557A.
    Kidney international, 1994, Volume: 46, Issue:4

    Topics: Animals; Benzofurans; Dinoprostone; Fatty Acids; Fatty Acids, Essential; Kidney; Kidney Cortex; Male; Models, Biological; Nephrectomy; Rats; Rats, Sprague-Dawley; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Time Factors

1994
A renal vasodilator effect of angiotensin II revealed by dual thromboxane inhibition.
    Canadian journal of physiology and pharmacology, 1994, Volume: 72, Issue:6

    Topics: Angiotensin II; Animals; Benzofurans; Blood Pressure; Rats; Rats, Sprague-Dawley; Renal Circulation; Thromboxane-A Synthase; Thromboxanes; Vascular Resistance; Vasodilation

1994
Cyclooxygenase and lipoxygenase inhibition by BW-755C reduces acrolein smoke-induced acute lung injury.
    Journal of applied physiology (Bethesda, Md. : 1985), 1994, Volume: 77, Issue:2

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acrolein; Animals; Benzofurans; Blood Proteins; Cyclooxygenase Inhibitors; Eicosanoids; Indomethacin; Inflammation Mediators; Lipoxygenase Inhibitors; Lymph; Oxygen Consumption; Pulmonary Circulation; Sheep; Smoke Inhalation Injury; Thromboxane-A Synthase; Vascular Resistance

1994
Thromboxane synthase inhibition enhances furosemide-induced renal vasodilation.
    Clinical and investigative medicine. Medecine clinique et experimentale, 1993, Volume: 16, Issue:5

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Benzofurans; Diuresis; Drug Interactions; Furosemide; Indomethacin; Kidney; Male; p-Aminohippuric Acid; Rats; Rats, Sprague-Dawley; Thromboxane-A Synthase; Vasodilation

1993
Long-term renal preservation and prevention of acute tubular necrosis by inhibition of arachidonate metabolism.
    Transplantation proceedings, 1993, Volume: 25, Issue:4

    Topics: Animals; Arachidonic Acids; Benzofurans; Dogs; Female; Imidazoles; Kidney Transplantation; Kidney Tubular Necrosis, Acute; Organ Preservation; Pyridines; Thromboxane-A Synthase

1993
Prolonged kidney preservation by inhibition of arachidonic acid metabolism.
    Transplantation proceedings, 1993, Volume: 25, Issue:1 Pt 2

    Topics: Animals; Arachidonic Acids; Aspirin; Benzofurans; Creatinine; Diethylcarbamazine; Dogs; Female; Graft Survival; Kidney; Kidney Transplantation; Organ Preservation; Perfusion; Time Factors; Transplantation, Autologous; Transplantation, Heterologous

1993
Five-to-seven-day kidney preservation with aspirin and furegrelate.
    Transplantation, 1993, Volume: 55, Issue:4

    Topics: Animals; Aspirin; Benzofurans; Creatinine; Dogs; Female; Kidney; Kidney Transplantation; Organ Preservation; Prostaglandin Antagonists; Prostaglandins; Thromboxane-A Synthase; Thromboxanes; Time Factors

1993
Effect of new thromboxane A2 synthesis inhibitor tetramethyl-pyrazine on pancreatic transplantation in diabetic rats.
    Transplantation proceedings, 1996, Volume: 28, Issue:3

    Topics: Albuminuria; Animals; Benzofurans; beta 2-Microglobulin; Cyclosporine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Enzyme Inhibitors; Immunosuppressive Agents; Kidney; Organ Size; Pancreas Transplantation; Pyrazines; Rats; Rats, Wistar; Thromboxane A2; Thromboxane-A Synthase; Transplantation, Isogeneic

1996
Arginine vasopressin interacts with thromboxane in hydronephrosis.
    The American journal of physiology, 1997, Volume: 272, Issue:1 Pt 2

    Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Arterioles; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydrazines; Hydronephrosis; In Vitro Techniques; Male; Rats; Rats, Sprague-Dawley; Reference Values; Renal Circulation; Thromboxane-A Synthase; Thromboxanes; Vasoconstriction

1997
Long-term renal preservation and prevention of acute tubular necrosis by inhibition of arachidonate metabolism.
    Swiss surgery = Schweizer Chirurgie = Chirurgie suisse = Chirurgia svizzera, 1995, Issue:4

    Topics: Adenosine; Allopurinol; Animals; Arachidonic Acid; Aspirin; Benzofurans; Dogs; Enzyme Inhibitors; Female; Glutathione; Ibuprofen; Imidazoles; Insulin; Kidney Transplantation; Kidney Tubular Necrosis, Acute; Kidney Tubules; Leukotriene Antagonists; Leukotrienes; Organ Preservation; Organ Preservation Solutions; Pyridines; Raffinose; Thromboxane-A Synthase

1995
Inhibition of thromboxane synthesis attenuates insulin hypertension in rats.
    American journal of hypertension, 1997, Volume: 10, Issue:10 Pt 1

    Topics: Animals; Benzofurans; Glomerular Filtration Rate; Hyperinsulinism; Hypertension; Male; Potassium; Rats; Rats, Sprague-Dawley; Sodium; Thromboxane-A Synthase; Thromboxanes

1997
Changes in glomerular thromboxane A2 receptor expression and ligand binding following immune injury.
    Kidney international, 1999, Volume: 55, Issue:1

    Topics: Animals; Benzofurans; Disease Models, Animal; Enzyme Inhibitors; Glomerular Filtration Rate; Glomerulonephritis; Kidney Glomerulus; Kinetics; Ligands; Male; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Thromboxane A2; Thromboxane-A Synthase

1999
Thromboxane A(2) regulation of endothelial cell migration, angiogenesis, and tumor metastasis.
    Biochemical and biophysical research communications, 2000, Jan-07, Volume: 267, Issue:1

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Chemotaxis; Dinoprost; Dinoprostone; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Epoprostenol; Fatty Acids, Unsaturated; Fibroblast Growth Factor 2; Humans; Hydrazines; Lung Neoplasms; Lymphokines; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neovascularization, Pathologic; Rats; Receptors, Thromboxane; Thromboxane A2; Thromboxane-A Synthase; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2000
Perfusion of the hypothalamic paraventricular nucleus with N-methyl-D-aspartate produces thromboxane A2 and centrally activates adrenomedullary outflow in rats.
    Neuroscience, 2000, Volume: 96, Issue:3

    Topics: Adrenal Medulla; Animals; Benzofurans; Catecholamines; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; N-Methylaspartate; Paraventricular Hypothalamic Nucleus; Perfusion; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase

2000
Eicosapentaenoic acid suppresses PDGF-induced DNA synthesis in rat mesangial cells: involvement of thromboxane A2.
    Kidney international, 2000, Volume: 57, Issue:3

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Benzofurans; Cell Count; Cell Division; Cells, Cultured; Culture Media; DNA; Eicosapentaenoic Acid; Enzyme Inhibitors; Glomerular Mesangium; Indomethacin; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley; Thromboxane A2; Thymidine

2000
Shear stress-induced release of prostaglandin H(2) in arterioles of hypertensive rats.
    Hypertension (Dallas, Tex. : 1979), 2000, Volume: 35, Issue:4

    Topics: Animals; Arterioles; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydrazines; Hypertension; Prostaglandin H2; Prostaglandins H; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Prostaglandin; Receptors, Thromboxane A2, Prostaglandin H2; Stress, Mechanical; Thromboxane-A Synthase

2000
Effects of cyclo-oxygenase and thromboxane synthetase inhibitors on right atrial prostaglandins.
    The Journal of the Association of Physicians of India, 2000, Volume: 48, Issue:6

    Topics: Aspirin; Benzofurans; Coronary Artery Bypass; Coronary Disease; Culture Techniques; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Heart Atria; Humans; Indomethacin; Prostaglandins; Thromboxane A2; Thromboxane-A Synthase

2000
Effects of selective cyclooxygenase-2 inhibition on vascular responses and thrombosis in canine coronary arteries.
    Circulation, 2001, Aug-14, Volume: 104, Issue:7

    Topics: Acetylcholine; Animals; Arachidonic Acid; Aspirin; Benzofurans; Blood Flow Velocity; Celecoxib; Coronary Circulation; Coronary Thrombosis; Coronary Vessels; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Epoprostenol; Isoenzymes; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Thromboxane-A Synthase; Time Factors; Vasodilation; Vasomotor System

2001
Thromboxane synthase regulates the migratory phenotype of human glioma cells.
    Neuro-oncology, 1999, Volume: 1, Issue:1

    Topics: Arachidonic Acids; Aspirin; Astrocytes; Benzofurans; Brain Neoplasms; Cell Adhesion; Cell Movement; Enzyme Induction; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; GTP-Binding Proteins; Humans; Imidazoles; Indomethacin; Lysine; Models, Biological; Neoplasm Proteins; Neoplastic Stem Cells; Oligodendroglia; Pentanoic Acids; Phenotype; Pyridines; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Thromboxane B2; Thromboxane-A Synthase; Tumor Cells, Cultured

1999
Indomethacin protects permeability barrier from focal segmental glomerulosclerosis serum.
    Kidney international, 2002, Volume: 61, Issue:2

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Albumins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Benzofurans; Cell Membrane Permeability; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Enzyme Inhibitors; Glomerulosclerosis, Focal Segmental; Indomethacin; Kidney Glomerulus; Male; Proteinuria; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents

2002
Angiotensin II constriction of rat vasa recta is partially thromboxane dependent.
    Hypertension (Dallas, Tex. : 1979), 2002, Volume: 40, Issue:4

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 5,8,11,14-Eicosatetraynoic Acid; Angiotensin II; Animals; Benzofurans; Blood Vessels; Bridged Bicyclo Compounds, Heterocyclic; Culture Techniques; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Fatty Acids, Unsaturated; Female; Hydrazines; Indomethacin; Kidney Medulla; Kinetics; Lipoxygenase Inhibitors; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Thromboxane-A Synthase; Thromboxanes; Vasoconstriction; Vasoconstrictor Agents

2002
Role of brain thromboxane A2 in the release of noradrenaline and adrenaline from adrenal medulla in rats.
    European journal of pharmacology, 2003, Apr-25, Volume: 467, Issue:1-3

    Topics: Adrenal Medulla; Adrenalectomy; Animals; Arachidonic Acid; Benzofurans; Brain; Corticotropin-Releasing Hormone; Epinephrine; Injections, Intraventricular; Male; Norepinephrine; Rats; Rats, Wistar; Thromboxane A2; Vasopressins

2003
Inhibition of prostaglandin D2 clearance in rat hepatocytes by the thromboxane receptor antagonists daltroban and ifetroban and the thromboxane synthase inhibitor furegrelate.
    Biochemical pharmacology, 2003, Aug-15, Volume: 66, Issue:4

    Topics: Animals; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Complement C5a; Enzyme Inhibitors; Hepatocytes; Liver; Male; Metabolic Clearance Rate; Oxazoles; Perfusion; Phenylacetates; Prostaglandin D2; Rats; Rats, Wistar; Receptors, Thromboxane; Sulfonamides; Thromboxane B2; Thromboxane-A Synthase

2003
Inhibition of the arachidonic acid metabolism blocks endothelial cell migration and induces apoptosis.
    Acta neurochirurgica, 2004, Volume: 146, Issue:5

    Topics: Apoptosis; Arachidonic Acid; Aspirin; Benzofurans; Cell Culture Techniques; Cell Line, Tumor; Cell Movement; Cyclooxygenase Inhibitors; Endothelial Cells; Humans; Imidazoles; Neuroglia; Thromboxane-A Synthase

2004
Thromboxane A2 from Kupffer cells contributes to the hyperresponsiveness of hepatic portal circulation to endothelin-1 in endotoxemic rats.
    American journal of physiology. Gastrointestinal and liver physiology, 2005, Volume: 288, Issue:2

    Topics: Animals; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Endothelin-1; Endotoxemia; Fatty Acids, Unsaturated; Gadolinium; Hydrazines; Kupffer Cells; Lipopolysaccharides; Liver; Male; Portal Pressure; Portal System; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Thromboxane A2; Thromboxane-A Synthase

2005
Testosterone treatment increases thromboxane function in rat cerebral arteries.
    American journal of physiology. Heart and circulatory physiology, 2005, Volume: 289, Issue:2

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Androgens; Animals; Benzofurans; Body Weight; Bridged Bicyclo Compounds, Heterocyclic; Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydrazines; Male; Middle Cerebral Artery; Orchiectomy; Rats; Rats, Inbred F344; Receptors, Thromboxane; Testosterone; Thromboxane A2; Thromboxane-A Synthase; Vasoconstriction; Vasoconstrictor Agents; Vasodilation

2005
Brain prostanoid TP receptor-mediated adrenal noradrenaline secretion and EP3 receptor-mediated sympathetic noradrenaline release in rats.
    European journal of pharmacology, 2005, Apr-04, Volume: 512, Issue:1

    Topics: Adrenal Glands; Adrenalectomy; Animals; Benzofurans; Bombesin; Brain; Bridged Bicyclo Compounds; Dinoprostone; Fatty Acids, Monounsaturated; Injections, Intraventricular; Male; Norepinephrine; Rats; Rats, Wistar; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP3 Subtype; Receptors, Thromboxane; Sympathetic Nervous System; Thromboxane-A Synthase

2005
Gender difference in response to thromboxane A2/prostaglandin H2 receptor antagonism in spontaneously hypertensive rats.
    Gender medicine, 2004, Volume: 1, Issue:2

    Topics: Analysis of Variance; Animals; Benzofurans; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Female; Hemodynamics; Hydrazines; Male; Rats; Rats, Inbred SHR; Sex Factors; Thromboxane-A Synthase

2004
Involvement of brain thromboxane A in hypotension induced by haemorrhage in rats.
    Clinical and experimental pharmacology & physiology, 2005, Volume: 32, Issue:11

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzofurans; Blood Pressure; Disease Models, Animal; Epinephrine; Heart Rate; Hemorrhage; Hypotension; Hypothalamus; Injections, Intraventricular; Male; Rats; Rats, Sprague-Dawley; Thromboxane A2; Thromboxane-A Synthase; Time Factors; Vasoconstrictor Agents; Vasopressins

2005
The role of the central thromboxane A2 in cardiovascular effects of a phospholipase A2 activator melittin administrated intracerebroventricularly in normotensive conscious rats.
    Neuropeptides, 2006, Volume: 40, Issue:3

    Topics: Animals; Benzofurans; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fatty Acids, Unsaturated; Heart Rate; Hydrazines; Male; Melitten; Phospholipases A; Phospholipases A2; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane A2

2006
Centrally administered histamine evokes the adrenal secretion of noradrenaline and adrenaline by brain cyclooxygenase-1- and thromboxane A2-mediated mechanisms in rats.
    European journal of pharmacology, 2006, Jul-17, Volume: 541, Issue:3

    Topics: Adrenal Medulla; Adrenalectomy; Animals; Benzofurans; Brain; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epinephrine; Histamine; Histamine Agents; Injections, Intraventricular; Ketoprofen; Male; Nitrobenzenes; Norepinephrine; Rats; Rats, Wistar; Sulfonamides; Thromboxane A2

2006
Adrenal adrenaline- and noradrenaline-containing cells and celiac sympathetic ganglia are differentially controlled by centrally administered corticotropin-releasing factor and arginine-vasopressin in rats.
    European journal of pharmacology, 2007, Jun-14, Volume: 564, Issue:1-3

    Topics: Adrenal Medulla; Animals; Arachidonic Acid; Arginine Vasopressin; Benzofurans; Brain; Corticotropin-Releasing Hormone; Epinephrine; Ganglia, Sympathetic; Gene Expression; Genes, fos; Indomethacin; Injections, Intraventricular; Male; Norepinephrine; Photomicrography; Prostaglandins; Rats; Rats, Wistar; Thromboxane A2

2007
A change in the redox environment and thromboxane A2 production precede endothelial dysfunction in mice.
    American journal of physiology. Heart and circulatory physiology, 2007, Volume: 293, Issue:4

    Topics: Acetylcholine; Acetylcysteine; Aging; Animals; Antioxidants; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Catechin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Fatty Acids, Unsaturated; Gene Expression Regulation, Enzymologic; Hydrazines; Indomethacin; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroarginine; Oxidation-Reduction; Reactive Oxygen Species; Receptors, Thromboxane A2, Prostaglandin H2; Renal Artery; RNA, Messenger; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Vasodilator Agents

2007
Involvement of COX-1 in A3 adenosine receptor-mediated contraction through endothelium in mice aorta.
    American journal of physiology. Heart and circulatory physiology, 2007, Volume: 293, Issue:6

    Topics: Adenosine; Animals; Aorta; Benzofurans; Blotting, Western; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelium, Vascular; Indomethacin; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Knockout; Nitrobenzenes; Polymerase Chain Reaction; Pyrazoles; Pyridines; Receptor, Adenosine A3; Receptors, Thromboxane; RNA, Messenger; Signal Transduction; Sulfonamides; Thromboxane B2; Thromboxane-A Synthase; Vasoconstriction; Vasoconstrictor Agents

2007
Orchidectomy increases the formation of non-endothelial thromboxane A2 and modulates its role in the electrical field stimulation-induced response in rat mesenteric artery.
    The Journal of endocrinology, 2008, Volume: 197, Issue:2

    Topics: Animals; Benzofurans; Body Weight; Electric Stimulation; Epoprostenol; Male; Mesenteric Arteries; Nitric Oxide; Norepinephrine; Orchiectomy; Rats; Rats, Sprague-Dawley; Testosterone; Thromboxane A2; Thromboxane-A Synthase

2008
Centrally administered neuromedin U elevates plasma adrenaline by brain prostanoid TP receptor-mediated mechanisms in rats.
    European journal of pharmacology, 2008, Sep-11, Volume: 592, Issue:1-3

    Topics: Anesthesia; Anesthetics, Inhalation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Brain Chemistry; Bridged Bicyclo Compounds; Catecholamines; Enzyme Inhibitors; Epinephrine; Fatty Acids, Monounsaturated; Indomethacin; Injections, Intraventricular; Male; Neuropeptides; Prostaglandin Antagonists; Rats; Rats, Wistar; Receptors, Thromboxane; Thromboxane-A Synthase; Urethane

2008
Hypertension increases contractile responses to hydrogen peroxide in resistance arteries through increased thromboxane A2, Ca2+, and superoxide anion levels.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 328, Issue:1

    Topics: Animals; Benzofurans; Calcium; Endothelium, Vascular; Enzyme Inhibitors; Hydrogen Peroxide; Hypertension; Indomethacin; Male; Mesenteric Arteries; Myocardial Contraction; Organic Chemicals; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Superoxides; Thromboxane A2; Thromboxane-A Synthase

2009
Inhibition of invasion-associated thromboxane synthase sensitizes experimental gliomas to gamma-radiation.
    Journal of neuro-oncology, 2009, Volume: 91, Issue:3

    Topics: Animals; Animals, Inbred Strains; Astrocytes; Benzofurans; Brain Neoplasms; Cell Survival; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Enzyme Inhibitors; Gamma Rays; Gene Expression Regulation, Neoplastic; Glioma; Humans; Mice; Neoplasm Invasiveness; Radiation Tolerance; Thromboxane-A Synthase; Thromboxanes; Time Factors; Transfection

2009
Role of prostanoid production and receptors in the regulation of retinal endogenous amino acid neurotransmitters by 8-isoprostaglandin E2, ex vivo.
    Neurochemical research, 2009, Volume: 34, Issue:12

    Topics: Animals; Benzofurans; Biphenyl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cyclooxygenase Inhibitors; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Dinoprostone; Fatty Acids, Unsaturated; Flurbiprofen; Glutamic Acid; Glutamine; Glycine; Hydrazines; Isoprostanes; Neurotransmitter Agents; Nitrobenzenes; Prostaglandins; Receptors, Prostaglandin; Retina; Sulfonamides; Xanthones

2009
Ovariectomy increases the formation of prostanoids and modulates their role in acetylcholine-induced relaxation and nitric oxide release in the rat aorta.
    Cardiovascular research, 2009, Nov-01, Volume: 84, Issue:2

    Topics: Acetylcholine; Animals; Aorta; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Epoprostenol; Fatty Acids, Unsaturated; Female; Hydrazines; Intramolecular Oxidoreductases; Membrane Proteins; Nitric Oxide; Nitrobenzenes; Ovariectomy; Prostaglandins; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase; Tranylcypromine; Vasodilation; Vasodilator Agents

2009
Central mechanism underlying pressor and bradycardic effect of intracerebroventricularly injected arachidonic acid.
    Canadian journal of physiology and pharmacology, 2011, Volume: 89, Issue:2

    Topics: Animals; Arachidonic Acid; Benzofurans; Blood Pressure; Bradycardia; Bridged Bicyclo Compounds, Heterocyclic; Cardiovascular System; Fatty Acids, Unsaturated; Heart Rate; Hydrazines; Indomethacin; Infusions, Intraventricular; Male; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane A2, Prostaglandin H2; Signal Transduction; Thromboxane A2

2011
Up-regulation of thromboxane A₂ impairs cerebrovascular eNOS function in aging atherosclerotic mice.
    Pflugers Archiv : European journal of physiology, 2011, Volume: 462, Issue:3

    Topics: Acetophenones; Aging; Animals; Antioxidants; Atherosclerosis; Benzofurans; Catechin; Cerebral Arteries; Enzyme Inhibitors; Hemodynamics; Humans; Hydrogen Peroxide; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type III; Oxidants; Oxidative Stress; Receptors, LDL; Thromboxane A2; Thromboxane-A Synthase; Up-Regulation

2011
Kupffer cell depletion attenuates leptin-mediated methoxamine-stimulated portal perfusion pressure and thromboxane A2 release in a rodent model of NASH-cirrhosis.
    Clinical science (London, England : 1979), 2012, Volume: 123, Issue:12

    Topics: Analysis of Variance; Animals; Arachidonic Acid; Benzofurans; Choline; Clodronic Acid; Diet, High-Fat; DNA Primers; Fatty Acids, Unsaturated; Fatty Liver; Gadolinium; Hemodynamics; Hypertension, Portal; Insulin Resistance; Kupffer Cells; Leptin; Methionine; Methoxamine; Microcirculation; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Rats; Receptors, Thromboxane A2, Prostaglandin H2; RNA, Messenger; Sulfonylurea Compounds; Thiobarbituric Acid Reactive Substances; Thromboxane A2

2012
Thromboxane A2 exerts promoting effects on cell proliferation through mediating cyclooxygenase-2 signal in lung adenocarcinoma cells.
    Journal of cancer research and clinical oncology, 2014, Volume: 140, Issue:3

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Apoptosis; Benzofurans; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fatty Acids, Unsaturated; Flow Cytometry; Humans; Hydrazines; Immunoenzyme Techniques; Lung Neoplasms; Nitrobenzenes; Real-Time Polymerase Chain Reaction; Receptors, Thromboxane; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sulfonamides; Sulfonylurea Compounds; Thromboxane A2; Thromboxane-A Synthase

2014
Brain thromboxane A2 via arachidonic acid cascade induces the hypothalamic-pituitary-gonadal axis activation in rats.
    Autonomic neuroscience : basic & clinical, 2015, Volume: 189

    Topics: Animals; Arachidonic Acid; Benzofurans; Brain; Dose-Response Relationship, Drug; Enzyme Inhibitors; Follicle Stimulating Hormone; Growth Hormone-Releasing Hormone; Ibuprofen; Infusions, Intraventricular; Luteinizing Hormone; Male; Prostaglandin-Endoperoxide Synthases; Rats, Sprague-Dawley; Signal Transduction; Sperm Count; Sperm Motility; Testosterone; Thromboxane A2; Time Factors

2015
The effects of centrally injected arachidonic acid on respiratory system: Involvement of cyclooxygenase to thromboxane signaling pathway.
    Respiratory physiology & neurobiology, 2016, Volume: 225

    Topics: Anesthesia; Animals; Arachidonic Acid; Benzofurans; Carbon Dioxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ibuprofen; Injections, Intraventricular; Male; Oxygen; Prostaglandin-Endoperoxide Synthases; Rats, Sprague-Dawley; Respiration; Respiratory System; Respiratory System Agents; Thromboxane A2; Tidal Volume; Time Factors

2016
NO synthase inhibition attenuates EDHF-mediated relaxation induced by TRPV4 channel agonist GSK1016790A in the rat pulmonary artery: Role of TxA2.
    Pharmacological reports : PR, 2016, Volume: 68, Issue:3

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Apamin; Benzofurans; Biological Factors; Dioxanes; Dose-Response Relationship, Drug; In Vitro Techniques; Leucine; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Potassium; Pulmonary Artery; Pyrazoles; Rats; Receptors, Thromboxane A2, Prostaglandin H2; Sulfonamides; TRPV Cation Channels; Vasodilation

2016
Thromboxane A
    European journal of pharmacology, 2020, May-15, Volume: 875

    Topics: Adrenal Medulla; Animals; Benzofurans; Blood Glucose; Deoxyglucose; Epinephrine; Indomethacin; Injections, Intraventricular; Male; Neurons; Norepinephrine; Paraventricular Hypothalamic Nucleus; Phentolamine; Rats; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Thromboxane A2

2020
Comparative study on the effect of aspirin, TP receptor antagonist and TxA
    Life sciences, 2021, Dec-01, Volume: 286

    Topics: Arachidonic Acid; Aspirin; Benzofurans; Carbazoles; Enzyme Inhibitors; Female; Humans; Male; Mammary Arteries; Muscle, Smooth, Vascular; Phenylephrine; Receptors, Prostaglandin; Receptors, Thromboxane; Saphenous Vein; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase; Thromboxanes; Vasoconstriction

2021