furafylline and quinidine

furafylline has been researched along with quinidine in 33 studies

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (9.09)18.2507
2000's11 (33.33)29.6817
2010's19 (57.58)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hashizume, H; Kawasaki, M; Komatsu, M; Matsumoto, M; Sasaki, H; Shimokawa, Y; Tomishige, T; Tsubouchi, H1
Fetzer, L; Frotscher, M; Hartmann, RW; Kruchten, P; Marchais-Oberwinkler, S; Messinger, J; Müller-Vieira, U; Neugebauer, A; Scherer, C; Thole, H; Ziegler, E1
Birk, B; Grombein, CM; Hartmann, RW; Heim, R; Lucas, S; Müller-Vieira, U; Negri, M; Ries, C; Schewe, KE1
Antes, I; Bisi, A; Gobbi, S; Hartmann, RW; Heim, R; Lucas, S; Negri, M; Ries, C; Schewe, KE1
Birk, B; Hartmann, RW; Heim, R; Lucas, S; Ries, C; Schewe, KE1
Dai, R; Liu, Y; She, M; Wu, Z1
Barreiro, EJ; da Silva, LL; Fraga, AG; Fraga, CA1
Frotscher, M; Hartmann, RW; Henn, C; Kruchten, P; Marchais-Oberwinkler, S; Werth, R; Wetzel, M; Ziegler, E1
Hartmann, RW; Heim, R; Lucas, S; Negri, M; Zimmer, C1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Calvet, CM; Cameron, MD; Choi, JY; Gunatilleke, SS; McKerrow, JH; Podust, LM; Roush, WR; Ruiz, C1
Andréola, ML; Bailly, F; Calmels, C; Christ, F; Cotelle, P; Debyser, Z; Lion, C; Suchaud, V1
Ahn, YG; Bang, HJ; Hong, DJ; Jung, SH; Kim, D; Kim, EY; Kim, J; Kim, M; Kim, YJ; Lee, K; Min, KH; Park, EJ; Suh, KH1
Bracke, ME; De Ryck, T; Katritzky, AR; Patronov, A; Roman, BI; Slavov, SH; Stevens, CV; Vanhoecke, BW1
Cho, H; Elkamhawy, A; Heo, JC; Kim, HY; Kim, KH; Lee, CO; Nam, DH; Pae, AN; Park, WK; Roh, EJ; Seol, HJ; Viswanath, AN; Yang, H1
Budriesi, R; Carosati, E; Chiarini, A; Chiu, FC; Cosimelli, B; Frosini, M; Fusi, F; Ioan, P; Katneni, K; Matucci, R; Micucci, M; Saponara, S; Severi, E; Spinelli, D1
Andréola, ML; Bailly, F; Billamboz, M; Christ, F; Cotelle, P; Debyser, Z; Lion, C; Suchaud, V1
Aljayyoussi, G; Amewu, RK; Angulo-Barturén, I; Bazaga, SF; Belén, M; Biagini, GA; Campo, B; Charman, SA; Chen, G; Davies, J; Martínez, MS; Nixon, GL; O' Neill, PM; Roberts, NL; Ryan, E; Sabbani, S; Shackleford, DM; Sharma, R; Shore, ER; Stocks, PA; Ward, SA1
Huan, Y; Liu, Z; Pan, X; Shen, Z; Sun, Z; Xiao, Z; Yang, Y; Zhou, T1
Battista, MR; Brun, R; Calvet, CM; Cirilli, R; Costi, R; De Leo, A; De Vita, D; Di Marco, A; Di Santo, R; Faggi, C; Jennings, GK; Kaiser, M; Madia, VN; Mäser, P; Messore, A; Pepe, G; Pescatori, L; Podust, LM; Saccoliti, F; Scipione, L; Summa, V; Tudino, V1
Caligari, S; Callegari, E; De Toma, C; Dilernia, R; Frigerio, F; Graziani, D; Longhi, M; Menegon, S; Pinzi, L; Pirona, L; Rastelli, G; Riva, C; Tazzari, V; Valsecchi, AE; Vistoli, G1
Adebesin, AM; Falck, JR; Fischer, R; Konkel, A; Lossie, J; Paudyal, MP; Puli, N; Schunck, WH; Vijaykumar, J; Wesser, T; Westphal, C; Zhu, C1
Bayliss, MK; Eddershaw, PJ; Herriott, D; Manchee, GR; Park, GR; Ranshaw, LE; Tarbit, MH1
Jones, BC; Smith, DA; Tyman, CA1
Hata, T; Iwasaki, K; Kaneko, H; Shiraga, T; Suzuki, A; Tozuka, Z1
Beckurts, KT; Brachtendorf, L; Fuhr, U; Hölscher, AH; Jetter, A1
Hyland, R; Jones, BC; Smith, DA1
Chiba, K; Kobayashi, K; Shimada, N; Urashima, K1
Fouda, HG; Khojasteh-Bakht, SC; Prakash, C; Rossulek, MI1
Gottesdiener, KM; Kari, PP; Marbury, T; Miller, JL; Mistry, GC; Rodrigues, AD; Simpson, RC; Wagner, JA; Winchell, GA1
Fuhr, U; Kober, S; Mutschler, E; Spahn-Langguth, H; Zaigler, M1
Erve, JC; Vashishtha, SC; Wu, G1
Camenisch, G; Chibale, K; Huth, F; Njuguna, NM; Schiller, H; Umehara, KI1

Trials

1 trial(s) available for furafylline and quinidine

ArticleYear
The effect of ketoconazole on the pharmacokinetics of a selective alpha 1A-adrenoceptor antagonist.
    Journal of clinical pharmacology, 2005, Volume: 45, Issue:6

    Topics: Administration, Oral; Adrenergic alpha-1 Receptor Antagonists; Adult; Area Under Curve; Carbon Radioisotopes; Coumarins; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Fomepizole; Half-Life; Humans; Ketoconazole; Male; Microsomes, Liver; Pyrazoles; Pyrimidinones; Quinidine; Receptors, Adrenergic, alpha-1; Sulfaphenazole; Theophylline

2005

Other Studies

32 other study(ies) available for furafylline and quinidine

ArticleYear
OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice.
    PLoS medicine, 2006, Volume: 3, Issue:11

    Topics: Animals; Antitubercular Agents; Blood; Cell Line; Humans; In Vitro Techniques; Intracellular Membranes; Macrophages; Mammals; Mice; Microbial Sensitivity Tests; Microsomes, Liver; Mycobacterium; Mycobacterium bovis; Mycolic Acids; Nitroimidazoles; Oxazoles; Treatment Outcome; Tuberculosis

2006
Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent disease
    Journal of medicinal chemistry, 2008, Apr-10, Volume: 51, Issue:7

    Topics: 17-Hydroxysteroid Dehydrogenases; Animals; Aryl Hydrocarbon Hydroxylases; Binding Sites; Caco-2 Cells; Computer Simulation; Drug Design; Enzyme Inhibitors; Estrogens; Humans; Hydrogen Bonding; Liver; Male; Microsomes, Liver; Models, Molecular; Molecular Structure; Naphthalenes; Neoplasms, Hormone-Dependent; Quinolines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship

2008
Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity.
    Journal of medicinal chemistry, 2008, Aug-28, Volume: 51, Issue:16

    Topics: Animals; Cytochrome P-450 CYP11B2; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Fibrosis; Heart Failure; Humans; Male; Myocardium; Naphthalenes; Rats; Rats, Wistar; Structure-Activity Relationship

2008
Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Acids, Carbocyclic; Binding Sites; Computer Simulation; Crystallography, X-Ray; Cytochrome P-450 CYP11B2; Dose-Response Relationship, Drug; Drug Design; Humans; Ligands; Models, Chemical; Models, Molecular; Molecular Structure; Naphthalenes; Stereoisomerism; Structure-Activity Relationship

2008
In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.
    Journal of medicinal chemistry, 2008, Dec-25, Volume: 51, Issue:24

    Topics: Animals; Carbon; Chemistry, Pharmaceutical; Cytochrome P-450 CYP11B2; Cytochrome P-450 CYP1A2; Drug Design; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Liver; Pyridines; Quinolones; Rats; Temperature; U937 Cells

2008
The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors.
    Journal of enzyme inhibition and medicinal chemistry, 2011, Volume: 26, Issue:3

    Topics: Cytochrome P-450 Enzyme Inhibitors; Enzyme Activation; Enzyme Inhibitors; Glucuronosyltransferase; Humans; Molecular Structure; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity

2011
CYP1A2-mediated biotransformation of cardioactive 2-thienylidene-3,4-methylenedioxybenzoylhydrazine (LASSBio-294) by rat liver microsomes and human recombinant CYP enzymes.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:1

    Topics: Animals; Biotransformation; Catalytic Domain; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Heart; Humans; Hydrazones; Male; Mass Spectrometry; Microsomes, Liver; Models, Molecular; Rats; Rats, Wistar; Recombinant Proteins; Thiophenes

2011
New drug-like hydroxyphenylnaphthol steroidomimetics as potent and selective 17β-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of estrogen-dependent diseases.
    Journal of medicinal chemistry, 2011, Jan-27, Volume: 54, Issue:2

    Topics: 17-Hydroxysteroid Dehydrogenases; Administration, Oral; Animals; Biological Availability; Cell Line, Tumor; Cell Membrane Permeability; Cell-Free System; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Female; Humans; Liver; Male; Microsomes; Molecular Mimicry; Naphthols; Phenols; Placenta; Pregnancy; Rats; Rats, Sprague-Dawley; Rats, Wistar; Recombinant Proteins; Steroids; Structure-Activity Relationship

2011
Fine-tuning the selectivity of aldosterone synthase inhibitors: structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-one derivatives.
    Journal of medicinal chemistry, 2011, Apr-14, Volume: 54, Issue:7

    Topics: Animals; Cytochrome P-450 CYP11B2; Drug Design; Enzyme Inhibitors; Humans; Male; Models, Molecular; Protein Conformation; Quinolines; Rats; Rats, Wistar; Structure-Activity Relationship; Substrate Specificity

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents.
    Journal of medicinal chemistry, 2013, Oct-10, Volume: 56, Issue:19

    Topics: 14-alpha Demethylase Inhibitors; Aminopyridines; Animals; Crystallography, X-Ray; Humans; Indoles; Mice; Microsomes, Liver; Molecular Docking Simulation; Rats; Stereoisomerism; Sterol 14-Demethylase; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi

2013
Investigation of a novel series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as human immunodeficiency virus type 1 integrase inhibitors.
    Journal of medicinal chemistry, 2014, Jun-12, Volume: 57, Issue:11

    Topics: Aryl Hydrocarbon Hydroxylases; Cell Line, Tumor; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Resistance, Viral; HIV Integrase Inhibitors; HIV-1; Humans; Isoquinolines; Molecular Docking Simulation; Mutation; Structure-Activity Relationship

2014
Discovery of novel pyrimidine and malonamide derivatives as TGR5 agonists.
    Bioorganic & medicinal chemistry letters, 2014, Sep-01, Volume: 24, Issue:17

    Topics: Animals; Biological Availability; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Discovery; HEK293 Cells; Humans; Malonates; Mice; Mice, Inbred ICR; Microsomes, Liver; Molecular Structure; Pyrimidines; Receptors, G-Protein-Coupled; Structure-Activity Relationship

2014
4-Fluoro-3',4',5'-trimethoxychalcone as a new anti-invasive agent. From discovery to initial validation in an in vivo metastasis model.
    European journal of medicinal chemistry, 2015, Aug-28, Volume: 101

    Topics: Animals; Antineoplastic Agents, Phytogenic; Biological Products; Cell Line, Tumor; Cell Movement; Cell Survival; Chalcones; Chick Embryo; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Female; Humans; Mice; Mice, Nude; Molecular Structure; Myocardium; Neoplasm Invasiveness; Neoplasm Metastasis; Quantitative Structure-Activity Relationship

2015
Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme (GBM).
    European journal of medicinal chemistry, 2015, Oct-20, Volume: 103

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Dose-Response Relationship, Drug; Drug Discovery; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Glioblastoma; Humans; Models, Molecular; Molecular Conformation; Quinazolines; Structure-Activity Relationship; Temozolomide; Urea

2015
Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism.
    Journal of medicinal chemistry, 2016, Apr-14, Volume: 59, Issue:7

    Topics: Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Guinea Pigs; Heart Atria; Humans; Male; Microsomes, Liver; Myocytes, Cardiac; Oxadiazoles; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazines; Vasodilator Agents

2016
2-hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs) as human immunodeficiency virus type 1 integrase inhibitors: Influence of the alkylcarboxamide substitution of position 4.
    European journal of medicinal chemistry, 2016, Jul-19, Volume: 117

    Topics: Alkylation; Anti-HIV Agents; Cell Line; Drug Resistance, Viral; HIV Integrase Inhibitors; Humans; Isoquinolines; Structure-Activity Relationship

2016
Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria.
    Bioorganic & medicinal chemistry, 2018, 07-15, Volume: 26, Issue:11

    Topics: Administration, Oral; Animals; Antimalarials; Disease Models, Animal; Drug Stability; Humans; Inhibitory Concentration 50; Malaria; Mice; Morpholines; Plasmodium falciparum; Rats; Tetraoxanes

2018
Design, synthesis and biological evaluation of a series of novel GPR40 agonists containing nitrogen heterocyclic rings.
    Bioorganic & medicinal chemistry letters, 2018, 10-01, Volume: 28, Issue:18

    Topics: Animals; Dose-Response Relationship, Drug; Drug Design; Isoindoles; Mice; Mice, Inbred ICR; Molecular Structure; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Tetrahydroisoquinolines

2018
Design, Synthesis, and Biological Evaluation of New 1-(Aryl-1 H-pyrrolyl)(phenyl)methyl-1 H-imidazole Derivatives as Antiprotozoal Agents.
    Journal of medicinal chemistry, 2019, 02-14, Volume: 62, Issue:3

    Topics: Animals; Antiprotozoal Agents; Cytochrome P-450 Enzyme Inhibitors; Drug Design; Drug Evaluation, Preclinical; Humans; Imidazoles; Parasitic Sensitivity Tests; Trypanosoma

2019
Evaluation of Amides, Carbamates, Sulfonamides, and Ureas of 4-Prop-2-ynylidenecycloalkylamine as Potent, Selective, and Bioavailable Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5.
    Journal of medicinal chemistry, 2019, 02-14, Volume: 62, Issue:3

    Topics: Allosteric Regulation; Amides; Animals; Biological Availability; Carbamates; CHO Cells; Cricetulus; Dogs; Excitatory Amino Acid Agents; Humans; Ligands; Rats; Receptor, Metabotropic Glutamate 5; Structure-Activity Relationship; Sulfonamides; Urea

2019
Development of Robust 17(
    Journal of medicinal chemistry, 2019, 11-27, Volume: 62, Issue:22

    Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Arachidonic Acids; Dose-Response Relationship, Drug; Drug Stability; Epoxide Hydrolases; Esterification; Hepatocytes; Humans; Male; Mice; Microsomes, Liver; Myocardial Infarction; Myocytes, Cardiac; Rats, Sprague-Dawley; Rats, Wistar

2019
The aliphatic oxidation of salmeterol to alpha-hydroxysalmeterol in human liver microsomes is catalyzed by CYP3A.
    Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:5

    Topics: Adrenergic beta-Agonists; Albuterol; Biomarkers; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disulfiram; Humans; Isoenzymes; Ketoconazole; Microsomes, Liver; Midazolam; Molecular Structure; Oxidation-Reduction; Quinidine; Recombinant Proteins; Salmeterol Xinafoate; Sulfaphenazole; Theophylline

1996
Identification of the cytochrome P450 isoforms involved in the O-demethylation of 4-nitroanisole in human liver microsomes.
    Xenobiotica; the fate of foreign compounds in biological systems, 1997, Volume: 27, Issue:10

    Topics: Adult; Aged; Anisoles; Anti-Infective Agents; Anticoagulants; Antifungal Agents; Antimalarials; Binding, Competitive; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Isoenzymes; Ketoconazole; Kinetics; Male; Methylation; Microsomes, Liver; Middle Aged; Quinidine; Substrate Specificity; Sulfaphenazole; Theophylline

1997
Identification of cytochrome P450 enzymes involved in the metabolism of zotepine, an antipsychotic drug, in human liver microsomes.
    Xenobiotica; the fate of foreign compounds in biological systems, 1999, Volume: 29, Issue:3

    Topics: Antipsychotic Agents; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dibenzothiepins; Enzyme Inhibitors; Humans; Immune Sera; Isoenzymes; Ketoconazole; Microsomes, Liver; Oxidation-Reduction; Quinidine; Recombinant Proteins; Theophylline

1999
Cytochrome P450 enzymes contributing to demethylation of maprotiline in man.
    Pharmacology & toxicology, 2002, Volume: 90, Issue:3

    Topics: Cells, Cultured; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzymes; Humans; Ketoconazole; Kinetics; Maprotiline; Mephenytoin; Microsomes, Liver; Models, Biological; Quinidine; Sulfaphenazole; Theophylline

2002
Identification of the cytochrome P450 enzymes involved in the N-oxidation of voriconazole.
    Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:5

    Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Cyclic N-Oxides; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; In Vitro Techniques; Ketoconazole; Microsomes, Liver; Oxidation-Reduction; Pyrimidines; Quinidine; Sulfaphenazole; Theophylline; Triazoles; Voriconazole

2003
Selectivities of human cytochrome P450 inhibitors toward rat P450 isoforms: study with cDNA-expressed systems of the rat.
    Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:7

    Topics: Aniline Compounds; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; DNA, Complementary; Enzyme Inhibitors; Gene Expression; Humans; Isoenzymes; Ketoconazole; Methoxsalen; Microsomes, Liver; Quinidine; Rats; Steroid 16-alpha-Hydroxylase; Steroid 21-Hydroxylase; Steroid Hydroxylases; Substrate Specificity; Sulfaphenazole; Theophylline

2003
Identification of the human cytochrome P450s responsible for the in vitro metabolism of a leukotriene B4 receptor antagonist, CP-195,543.
    Xenobiotica; the fate of foreign compounds in biological systems, 2003, Volume: 33, Issue:12

    Topics: Adolescent; Adult; Aged; Chromans; Coumarins; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Ketoconazole; Kinetics; Male; Mephenytoin; Microsomes, Liver; Middle Aged; NADP; Oxidation-Reduction; Quinidine; Receptors, Leukotriene B4; Recombinant Proteins; Sulfaphenazole; Theophylline

2003
Rate-limiting biotransformation of triamterene is mediated by CYP1A2.
    International journal of clinical pharmacology and therapeutics, 2005, Volume: 43, Issue:7

    Topics: Caffeine; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythromycin; Humans; Hydroxylation; Ketoconazole; Kinetics; Microsomes, Liver; Omeprazole; Quinidine; Substrate Specificity; Sulfuric Acid Esters; Theophylline; Triamterene

2005
Characterization of glutathione conjugates of duloxetine by mass spectrometry and evaluation of in silico approaches to rationalize the site of conjugation for thiophene containing drugs.
    Chemical research in toxicology, 2010, Aug-16, Volume: 23, Issue:8

    Topics: Animals; Binding Sites; Cytosol; Drug Design; Duloxetine Hydrochloride; Glutathione; Glutathione Transferase; Humans; Mass Spectrometry; Microsomes, Liver; Molecular Structure; Quinidine; Rationalization; Rats; Structure-Activity Relationship; Theophylline; Thiophenes

2010
Improvement of the chemical inhibition phenotyping assay by cross-reactivity correction.
    Drug metabolism and personalized therapy, 2016, 12-01, Volume: 31, Issue:4

    Topics: Acetates; Cyclopropanes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Ketoconazole; Phenotype; Quinidine; Quinolines; Sulfaphenazole; Sulfides; Theophylline; Ticlopidine

2016