fumimycin and vanillin

fumimycin has been researched along with vanillin* in 1 studies

Other Studies

1 other study(ies) available for fumimycin and vanillin

Article	Year
Synthesis of methoxyfumimycin with 1,2-addition to ketimines. The Journal of organic chemistry, 2010, Jan-01, Volume: 75, Issue:1 The synthesis of (+/-)-methoxyfumimycin, a potential new bacterial peptide deformylase (PDF) inhibitor, is reported. To generate the stereogenic fully substituted carbon, the key step is a 1,2-addition of a methyl Grignard reagent to a ketimine. The overall synthetic strategy involves a Dakin oxidation of a vanillin derivative, Friedel-Crafts acylation, Claisen rearrangement, lactonization, and rhodium-catalyzed olefin isomerization. Topics: Anti-Bacterial Agents; Benzaldehydes; Benzofurans; Catalysis; Imines; Magnetic Resonance Spectroscopy; Molecular Structure; Nitriles; Rhodium; Stereoisomerism	2010

Article

Year

Synthesis of methoxyfumimycin with 1,2-addition to ketimines.

The Journal of organic chemistry, 2010, Jan-01, Volume: 75, Issue:1

The synthesis of (+/-)-methoxyfumimycin, a potential new bacterial peptide deformylase (PDF) inhibitor, is reported. To generate the stereogenic fully substituted carbon, the key step is a 1,2-addition of a methyl Grignard reagent to a ketimine. The overall synthetic strategy involves a Dakin oxidation of a vanillin derivative, Friedel-Crafts acylation, Claisen rearrangement, lactonization, and rhodium-catalyzed olefin isomerization.

Topics: Anti-Bacterial Agents; Benzaldehydes; Benzofurans; Catalysis; Imines; Magnetic Resonance Spectroscopy; Molecular Structure; Nitriles; Rhodium; Stereoisomerism

2010