fumarprotocetraric-acid and protolichesterinic-acid

Neurodegenerative disorders, including Tauopathies that involve tau protein, base their pathological mechanism on forming proteinaceous aggregates, which has a deleterious effect on cells triggering an inflammatory response. Moreover, tau inhibitors can exert their mechanism of action through noncovalent and covalent interactions. Thus, Michael's addition appears as a feasible type of interaction involving an α, β unsaturated carbonyl moiety to avoid pathological confirmation and further cytotoxicity. Moreover, we isolated three compounds from Antarctic lichens

Topics: 4-Butyrolactone; Antarctic Regions; Ascomycota; Cell Line, Tumor; Fumarates; Humans; Lichens; Neurodegenerative Diseases; Parmeliaceae; Protein Aggregates; tau Proteins; Tauopathies