fumaric-acid and 4-ethyl-1-phospha-2-6-7-trioxabicyclo(2.2.2)octane-1-oxide

fumaric-acid has been researched along with 4-ethyl-1-phospha-2-6-7-trioxabicyclo(2.2.2)octane-1-oxide* in 1 studies

Other Studies

1 other study(ies) available for fumaric-acid and 4-ethyl-1-phospha-2-6-7-trioxabicyclo(2.2.2)octane-1-oxide

Article	Year
Derivatisation of carboxylic acid groups in pharmaceuticals for enhanced detection using liquid chromatography with electrospray ionisation tandem mass spectrometry. Rapid communications in mass spectrometry : RCM, 2005, Volume: 19, Issue:8 Tris(2,4,6-trimethoxyphenyl)phosphonium propylamine bromide (TMPP) has been used for the derivatisation of maleic, fumaric, sorbic and salicylic acids to facilitate determination using liquid chromatography/electrospray ionisation tandem mass spectrometry (LC/ESI-MS/MS) in positive ion mode. Detection limits, achieved using multiple reaction monitoring mode, were 2, 4, 0.4 and 540 fmol (5 muL injection) for derivatised fumaric, sorbic, maleic and salicylic acids, respectively. In comparison, detection limits achieved in negative ion mode for the underivatised acids were 24, 51, 2, and 117 fmol, respectively. The method was successfully used for the determination of sorbic acid in a sample of Panadol. The derivatisation of salicylic acid was not as successful, probably due to poor reaction efficiency. Topics: Acetaminophen; Analgesics, Non-Narcotic; Bridged Bicyclo Compounds, Heterocyclic; Carboxylic Acids; Chromatography, High Pressure Liquid; Fumarates; Maleates; Salicylic Acid; Sorbic Acid; Spectrometry, Mass, Electrospray Ionization	2005

Article

Year

Derivatisation of carboxylic acid groups in pharmaceuticals for enhanced detection using liquid chromatography with electrospray ionisation tandem mass spectrometry.

Rapid communications in mass spectrometry : RCM, 2005, Volume: 19, Issue:8

Tris(2,4,6-trimethoxyphenyl)phosphonium propylamine bromide (TMPP) has been used for the derivatisation of maleic, fumaric, sorbic and salicylic acids to facilitate determination using liquid chromatography/electrospray ionisation tandem mass spectrometry (LC/ESI-MS/MS) in positive ion mode. Detection limits, achieved using multiple reaction monitoring mode, were 2, 4, 0.4 and 540 fmol (5 muL injection) for derivatised fumaric, sorbic, maleic and salicylic acids, respectively. In comparison, detection limits achieved in negative ion mode for the underivatised acids were 24, 51, 2, and 117 fmol, respectively. The method was successfully used for the determination of sorbic acid in a sample of Panadol. The derivatisation of salicylic acid was not as successful, probably due to poor reaction efficiency.

Topics: Acetaminophen; Analgesics, Non-Narcotic; Bridged Bicyclo Compounds, Heterocyclic; Carboxylic Acids; Chromatography, High Pressure Liquid; Fumarates; Maleates; Salicylic Acid; Sorbic Acid; Spectrometry, Mass, Electrospray Ionization

2005