Page last updated: 2024-08-26

fulvestrant and wortmannin

fulvestrant has been researched along with wortmannin in 20 studies

Research

Studies (20)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	16 (80.00)	29.6817
2010's	4 (20.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Austin, C; Shaw, L; Taggart, MJ	1
Huper, G; Iglehart, JD; Lobenhofer, EK; Marks, JR	1
Banerjee, S; Banerjee, SK; Saxena, N; Sengupta, K	1
Czubayko, F; Franke, TF; List, HJ; Martin, MB; Morgan, E; Reiter, R; Stoica, A; Stoica, GE; Wellstein, A	1
Carroll, MA; Falck, JR; Huang, A; Jiang, H; Kaley, G; Sun, D; Wu, Z; Yan, C	1
Banerjee, S; Banerjee, SK; Saxena, NK; Sengupta, K	1
Aronovitz, MJ; Baur, J; Celestin, F; Chen, X; Force, T; Grohe, C; Haq, S; Karas, RH; Mendelsohn, ME; Michael, A; Nuedling, S; Patten, RD; Pourati, I	1
Angle, M; Florian, M; Lu, Y; Magder, S	1
Aguilar-Maldonado, B; Avendaño-Vázquez, SE; García-Sáinz, JA; González-Arenas, A	1
Környei, JL; Kovács, KA; Lengyel, F; Sümegi, B; Vértes, M; Vértes, Z	1
Bland, KI; Chaudry, IH; Choudhry, MA; Hsieh, YC; Schwacha, MG; Suzuki, T; Yu, HP	2
Bland, KI; Chaudry, IH; Choudhry, MA; Hsieh, CH; Hsu, JT; Kan, WH; Schwacha, MG	1
Chung, KY; Dayton, WR; Hathaway, MR; Johnson, BJ; Kamanga-Sollo, E; White, ME	1
Arici, A; Cakmak, H; Cinar, O; Kayisli, UA; Seval, Y; Ulukus, M; Uz, YH	1
Chan, YC; Chen, ZY; Huang, Y; Lau, CW; Leung, FP; Tian, XY; Tsang, SY; Wong, WT; Yao, X; Yung, LM	1
Arevalo, MA; Garcia-Segura, LM; Hernando, M; Ruiz-Palmero, I	1
Förstermann, U; Hohmann, N; Li, H; Steinkamp-Fenske, K; Xia, N	1

Other Studies

20 other study(ies) available for fulvestrant and wortmannin

Article	Year
Identifying off-target effects and hidden phenotypes of drugs in human cells. Nature chemical biology, 2006, Volume: 2, Issue:6 Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship	2006
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Mechanisms of 17 beta-oestradiol induced vasodilatation in isolated pressurized rat small arteries. British journal of pharmacology, 2000, Volume: 129, Issue:3 Topics: Androstadienes; Animals; Coronary Vessels; Cycloheximide; Endothelium, Vascular; Enzyme Inhibitors; Estradiol; Fulvestrant; In Vitro Techniques; Male; Mesenteric Arteries; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Pressure; Protein Synthesis Inhibitors; Rats; Rats, Inbred WKY; Receptors, Estrogen; Vasodilation; Wortmannin	2000
Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 2000, Volume: 11, Issue:2 Topics: Adenocarcinoma; Androstadienes; Breast Neoplasms; Butadienes; Chromones; Culture Media, Serum-Free; Cyclic AMP-Dependent Protein Kinases; Cyclin D1; Depression, Chemical; DNA Replication; Enzyme Activation; Enzyme Inhibitors; Estradiol; Estrogen Receptor Modulators; Estrogens; Female; Flavonoids; Fulvestrant; Humans; Isoquinolines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitosis; Morpholines; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Retinoblastoma Protein; Sulfonamides; Wortmannin	2000
17alpha-estradiol-induced VEGF-A expression in rat pituitary tumor cells is mediated through ER independent but PI3K-Akt dependent signaling pathway. Biochemical and biophysical research communications, 2003, Jan-03, Volume: 300, Issue:1 Topics: Androstadienes; Angiogenesis Inducing Agents; Animals; Enzyme Inhibitors; Estradiol; Estrogen Receptor Modulators; Fulvestrant; Gene Expression; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pituitary Neoplasms; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Puromycin; Rats; Receptors, Estrogen; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Wortmannin	2003
Estradiol rapidly activates Akt via the ErbB2 signaling pathway. Molecular endocrinology (Baltimore, Md.), 2003, Volume: 17, Issue:5 Topics: Androstadienes; Breast Neoplasms; Chromones; Enzyme Inhibitors; Estradiol; Estrogen Receptor alpha; Estrogen Receptor Modulators; Female; Fulvestrant; Genistein; Humans; Morpholines; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, ErbB-2; Receptors, Estrogen; Serine; Signal Transduction; Sirolimus; Tumor Cells, Cultured; Tyrphostins; Wortmannin	2003
Estrogen elicits cytochrome P450--mediated flow-induced dilation of arterioles in NO deficiency: role of PI3K-Akt phosphorylation in genomic regulation. Circulation research, 2004, Feb-06, Volume: 94, Issue:2 Topics: Androstadienes; Animals; Arterioles; Caproates; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Enzyme Induction; Enzyme Inhibitors; Estradiol; Female; Fulvestrant; Hemorheology; Indomethacin; Male; Miconazole; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal Transduction; Stress, Mechanical; Transcription, Genetic; Vasodilation; Wortmannin	2004
Thombospondin-1 disrupts estrogen-induced endothelial cell proliferation and migration and its expression is suppressed by estradiol. Molecular cancer research : MCR, 2004, Volume: 2, Issue:3 Topics: Androstadienes; Anthracenes; Antibodies; Butadienes; Cell Division; Cell Movement; Cells, Cultured; Down-Regulation; Endothelial Cells; Estradiol; Estrogen Antagonists; Fulvestrant; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Receptors, Estrogen; RNA, Messenger; Thrombospondin 1; Time Factors; Wortmannin	2004
17beta-estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of phospho-inositide-3 kinase/Akt signaling. Circulation research, 2004, Oct-01, Volume: 95, Issue:7 Topics: Amino Acid Chloromethyl Ketones; Androstadienes; Animals; Apoptosis; Cells, Cultured; Chromones; Enzyme Activation; Estradiol; Estrogen Receptor Modulators; Female; Fulvestrant; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Myocardial Infarction; Myocytes, Cardiac; Ovariectomy; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Recombinant Fusion Proteins; Signal Transduction; Wortmannin	2004
Estrogen induced changes in Akt-dependent activation of endothelial nitric oxide synthase and vasodilation. Steroids, 2004, Volume: 69, Issue:10 Topics: Acetylcholine; Androstadienes; Animals; Aorta; Blotting, Western; Cattle; Cell Line; Cerebral Veins; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Humans; In Vitro Techniques; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Ovariectomy; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Tamoxifen; Vasodilation; Wortmannin	2004
Estrogens cross-talk to alpha1b-adrenergic receptors. Molecular pharmacology, 2006, Volume: 70, Issue:1 Topics: Androstadienes; Animals; Blotting, Western; Calcium; Cell Line; Cell Line, Tumor; Cricetinae; Endocytosis; Estradiol; Estrogen Receptor alpha; Estrogens; Fulvestrant; Humans; Microscopy, Confocal; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C-delta; Receptor Cross-Talk; Receptors, Adrenergic, alpha-1; Staurosporine; Transfection; Wortmannin	2006
Effect of estrogen and inhibition of phosphatidylinositol-3 kinase on Akt and FOXO1 in rat uterus. Steroids, 2007, Volume: 72, Issue:5 Topics: Androstadienes; Animals; Enzyme Activation; Estradiol; Estrogen Antagonists; Estrogens; Female; Forkhead Transcription Factors; Fulvestrant; Nerve Tissue Proteins; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal Transduction; Uterus; Wortmannin	2007
The PI3K/Akt pathway mediates the nongenomic cardioprotective effects of estrogen following trauma-hemorrhage. Annals of surgery, 2007, Volume: 245, Issue:6 Topics: Analysis of Variance; Androstadienes; Animals; Cardiac Output; Estradiol; Estrogens; Fulvestrant; Male; Myocardium; Phosphatidylinositol 3-Kinases; Protective Agents; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Wortmannin; Wounds and Injuries	2007
Mechanism of the nongenomic effects of estrogen on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of the PI-3K/Akt pathway. Journal of leukocyte biology, 2007, Volume: 82, Issue:3 Topics: Androstadienes; Animals; Blotting, Western; Chemokine CXCL1; Chemokines, CXC; Estradiol; Estrogen Antagonists; Estrogen Receptor Modulators; Fulvestrant; Genome; Intercellular Adhesion Molecule-1; Interleukin-6; Intestine, Small; Male; Peroxidase; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Shock, Hemorrhagic; Up-Regulation; Wortmannin; Wounds and Injuries	2007
Mechanism of estrogen-mediated attenuation of hepatic injury following trauma-hemorrhage: Akt-dependent HO-1 up-regulation. Journal of leukocyte biology, 2007, Volume: 82, Issue:4 Topics: Androstadienes; Animals; Blood Pressure; Chemokine CXCL1; Chemokine CXCL2; Estradiol; Estrogen Antagonists; Estrogens; Fulvestrant; Gene Expression Regulation, Enzymologic; Glutathione Transferase; Heme Oxygenase-1; Hemorrhage; Intercellular Adhesion Molecule-1; Interleukin-6; Liver; Male; Peroxidase; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Resuscitation; Tumor Necrosis Factor-alpha; Up-Regulation; Wortmannin; Wounds and Injuries	2007
Roles of IGF-I and the estrogen, androgen and IGF-I receptors in estradiol-17beta- and trenbolone acetate-stimulated proliferation of cultured bovine satellite cells. Domestic animal endocrinology, 2008, Volume: 35, Issue:1 Topics: Anabolic Agents; Androstadienes; Animals; Cattle; Cell Proliferation; Cells, Cultured; Culture Media; Estradiol; Estrogen Antagonists; Flavonoids; Fulvestrant; Gene Expression; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinase Kinases; Receptor, IGF Type 1; Receptors, Androgen; Receptors, Estrogen; RNA, Messenger; Satellite Cells, Skeletal Muscle; Trenbolone Acetate; Wortmannin	2008
Differential regulation of Akt phosphorylation in endometriosis. Reproductive biomedicine online, 2009, Volume: 19, Issue:6 Topics: Androstadienes; Endometriosis; Endometrium; Estradiol; Female; Fulvestrant; Humans; Phosphorylation; Proto-Oncogene Proteins c-akt; Wortmannin	2009
Therapeutically relevant concentrations of raloxifene dilate pressurized rat resistance arteries via calcium-dependent endothelial nitric oxide synthase activation. Arteriosclerosis, thrombosis, and vascular biology, 2010, Volume: 30, Issue:5 Topics: Androstadienes; Animals; Apamin; Blood Pressure; Calcium Signaling; Charybdotoxin; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Female; Fulvestrant; In Vitro Techniques; Male; Mesenteric Arteries; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Ovariectomy; Phosphorylation; Potassium Channel Blockers; Protein Kinase Inhibitors; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Selective Estrogen Receptor Modulators; Sex Factors; Time Factors; Vascular Resistance; Vasodilation; Vasodilator Agents; Wortmannin	2010
G protein-coupled estrogen receptor is required for the neuritogenic mechanism of 17β-estradiol in developing hippocampal neurons. Molecular and cellular endocrinology, 2013, Jun-15, Volume: 372, Issue:1-2 Topics: Androstadienes; Animals; Basic Helix-Loop-Helix Transcription Factors; Cells, Cultured; Estradiol; Estrogens; Female; Fulvestrant; Gene Expression; Gene Expression Regulation; Hippocampus; Mice; Nerve Tissue Proteins; Neurites; Neurons; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Primary Cell Culture; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Receptors, Estrogen; Receptors, G-Protein-Coupled; Signal Transduction; Wortmannin	2013
Estrogen Receptor Signaling and the PI3K/Akt Pathway Are Involved in Betulinic Acid-Induced eNOS Activation. Molecules (Basel, Switzerland), 2016, Jul-25, Volume: 21, Issue:8 Topics: Androstadienes; Animals; Betulinic Acid; Cell Line; Chromones; Estradiol; Fibroblasts; Fulvestrant; Gene Expression Regulation; Humans; Lung; Morpholines; Nitric Oxide Synthase Type III; Pentacyclic Triterpenes; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Receptors, Estrogen; Signal Transduction; Triterpenes; Wortmannin	2016