Page last updated: 2024-08-26

fulvestrant and flutamide

fulvestrant has been researched along with flutamide in 30 studies

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (3.33)18.2507
2000's19 (63.33)29.6817
2010's9 (30.00)24.3611
2020's1 (3.33)2.80

Authors

AuthorsStudies
Bellavance, E; Luu-The, V; Poirier, D1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Carruba, G; Castagnetta, LA; Comito, L; D'Amico, D; Farruggio, R; Miceli, D; Montesanti, A; Polito, L1
Leung, SW; Man, RY; Quan, A; Teoh, H1
Damien, E; Lanyon, LE; Price, JS1
Appa Rao, KB; Gui, Y; Lessey, BA; Lovely, LP1
Chen, Q; Chihara, K; Kaji, H; Sugimoto, T1
Atkin, SL; Bilko, D; Newton, CJ; Pappa, S1
Clark, AS; Whitney, AC1
Brown, KM; Goering, PL; Papaconstantinou, AD; Umbreit, TH1
Dai, A; Dawood, T; Funder, JW; Komesaroff, PA; Lew, R; Ling, S; Myles, K; Sudhir, K; Williams, MR1
Browne, AE; Chatterjee, K; Chou, TM; Hutchison, SJ; Ko, E; Komesaroff, PA; Sudhir, K; Zellner, C1
Bland, KI; Chaudry, IH; Choudhry, MA; Hsieh, YC; Schwacha, MG; Yang, S; Yu, HP1
Härkönen, PL; Hentunen, TA; Michael, H; Väänänen, HK1
Chaudry, IH; Choudhry, MA; Hsieh, YC; Schwacha, MG; Shimizu, T; Yang, S; Yu, HP1
Anahara, R; Ishino, F; Kai, M; Maekawa, M; Mori, C; Toshimori, K; Toyama, Y; Yoshida, M1
Li, DJ; Wang, L; Wang, WJ; Wang, YD; Zhu, Y1
Akgul, Y; Derk, RC; Meighan, T; Murono, EP; Rao, KM1
Chung, KY; Dayton, WR; Johnson, BJ; Kamanga-Sollo, E; White, ME1
Davis, FB; Davis, PJ; Lin, C; Lin, HY; London, D; Shih, A; Sun, M; Tang, HY1
Bonthuis, P; Ding, A; Park, JH; Rais, S; Rissman, EF1
Affaitati, G; Aloisi, AM; Aurilio, C; Ceccarelli, I; Danielli, B; Fiorenzani, P; Giamberardino, MA; Pace, MC; Passavanti, MB; Rossi, C; Sorda, G1
Campelo, AE; Cutini, PH; Massheimer, VL1
Berger, T; Conley, AJ; Katleba, KD; Legacki, EL1
Freeman, MR; Pabelick, CM; Prakash, YS; Sathish, V; Thompson, MA; Wang, SY1
Fanton, LE; Fischer, L; Macedo, CG; Tambeli, CH; Torres-Chávez, KE1
Castro, LFC; Gonçalves, JF; Guimarães, C; Lopes, C; Madureira, TV; Malhão, F; Pinheiro, I; Rocha, E1
Ciereszko, RE; Czaja, E; Grzesiak, M; Knapczyk-Stwora, K; Koziorowski, M; Slomczynska, M1
Benyhe, S; Gáspár, R; Kothencz, A; Mirdamadi, M; Szécsi, M; Szűcs, E1

Reviews

1 review(s) available for fulvestrant and flutamide

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

2 trial(s) available for fulvestrant and flutamide

ArticleYear
Dehydroepiandrosterone increases endothelial cell proliferation in vitro and improves endothelial function in vivo by mechanisms independent of androgen and estrogen receptors.
    The Journal of clinical endocrinology and metabolism, 2004, Volume: 89, Issue:9

    Topics: Adult; Aged; Animals; Brachial Artery; Cattle; Cell Division; Cells, Cultured; Dehydroepiandrosterone; Double-Blind Method; Endothelial Cells; Estradiol; Female; Flutamide; Fulvestrant; Humans; Middle Aged; Mitogen-Activated Protein Kinases; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Receptors, Androgen; Receptors, Estrogen; Skin; Testosterone

2004
The impact of sex steroid agonists and antagonists on folliculogenesis in the neonatal porcine ovary via cell proliferation and apoptosis.
    Theriogenology, 2018, Volume: 113

    Topics: Androgen Antagonists; Androgens; Animals; Animals, Newborn; Apoptosis; Cell Proliferation; Estradiol; Estrogen Receptor Antagonists; Female; Flutamide; Fulvestrant; Granulosa Cells; Insecticides; Methoxychlor; Ovarian Follicle; Phenols; Swine; Testosterone Propionate

2018

Other Studies

27 other study(ies) available for fulvestrant and flutamide

ArticleYear
Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone.
    Journal of medicinal chemistry, 2009, Dec-10, Volume: 52, Issue:23

    Topics: 17-Hydroxysteroid Dehydrogenases; Androstane-3,17-diol; Androstanes; Biocatalysis; Cell Line; Dihydrotestosterone; Enzyme Inhibitors; Estradiol; Estrone; Humans; Inhibitory Concentration 50; Oxidation-Reduction; Substrate Specificity

2009
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Sex steroids up-regulate E-cadherin expression in hormone-responsive LNCaP human prostate cancer cells.
    Biochemical and biophysical research communications, 1995, Jul-17, Volume: 212, Issue:2

    Topics: Androgen Antagonists; Cadherins; Dihydrotestosterone; Estradiol; Estrogen Antagonists; Flutamide; Fulvestrant; Gonadal Steroid Hormones; Humans; Immunoblotting; Immunohistochemistry; Male; Prostatic Neoplasms

1995
Differential effects of 17beta-estradiol and testosterone on the contractile responses of porcine coronary arteries.
    British journal of pharmacology, 2000, Volume: 129, Issue:7

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Androgen Antagonists; Androgen Receptor Antagonists; Animals; Coronary Vessels; Cycloheximide; Cyproterone; Dactinomycin; Dose-Response Relationship, Drug; Endothelin-1; Estradiol; Estrogen Antagonists; Female; Flutamide; Fulvestrant; In Vitro Techniques; Isotonic Solutions; Male; Potassium Chloride; Receptors, Estrogen; Serotonin; Swine; Tamoxifen; Testosterone; Vasoconstriction

2000
Mechanical strain stimulates osteoblast proliferation through the estrogen receptor in males as well as females.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2000, Volume: 15, Issue:11

    Topics: Androgen Antagonists; Androstenedione; Animals; Antibodies; Aromatase Inhibitors; Cells, Cultured; Dihydrotestosterone; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrogens; Flutamide; Fulvestrant; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Male; Osteoblasts; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Stress, Mechanical; Tamoxifen; Testosterone; Thymidine

2000
Characterization of androgen receptors in a well-differentiated endometrial adenocarcinoma cell line (Ishikawa).
    The Journal of steroid biochemistry and molecular biology, 2000, Nov-15, Volume: 74, Issue:4

    Topics: Adenocarcinoma; Alkaline Phosphatase; Androgens; Cell Differentiation; Cell Nucleus; Diethylstilbestrol; Dihydrotestosterone; Endometrial Neoplasms; Endometrium; Estradiol; Estrogen Receptor Modulators; Estrogens; Female; Flutamide; Fulvestrant; Humans; Metribolone; Progesterone; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured

2000
Testosterone inhibits osteoclast formation stimulated by parathyroid hormone through androgen receptor.
    FEBS letters, 2001, Feb-23, Volume: 491, Issue:1-2

    Topics: Androgen Antagonists; Androstenedione; Animals; Aromatase Inhibitors; Cell Division; Cells, Cultured; Dihydrotestosterone; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Flutamide; Fulvestrant; Glucuronates; Mice; Mice, Inbred ICR; Osteoclasts; Parathyroid Hormone; Receptors, Androgen; Teriparatide; Testosterone

2001
Dexamethasone blocks antioestrogen- and oxidant-induced death of pituitary tumour cells.
    The Journal of endocrinology, 2001, Volume: 169, Issue:2

    Topics: Adenosine Triphosphate; Cell Death; Dexamethasone; Estradiol; Estrogen Receptor Modulators; Estrone; Flow Cytometry; Flutamide; Fulvestrant; Glucocorticoids; Glyceraldehyde-3-Phosphate Dehydrogenases; Gonanes; Humans; Hydrogen Peroxide; Microscopy, Fluorescence; Mifepristone; Pituitary Neoplasms; Reactive Oxygen Species; Receptor Cross-Talk; Receptors, Cell Surface; Transfection; Tumor Cells, Cultured

2001
Effects of acute stanozolol treatment on puberty in female rats.
    Biology of reproduction, 2001, Volume: 64, Issue:5

    Topics: Anabolic Agents; Androgen Antagonists; Animals; Dose-Response Relationship, Drug; Estradiol; Estrogen Antagonists; Estrus; Female; Flutamide; Fulvestrant; Rats; Rats, Long-Evans; Sexual Maturation; Stanozolol; Vagina

2001
Effects of 17 alpha-methyltestosterone on uterine morphology and heat shock protein expression are mediated through estrogen and androgen receptors.
    The Journal of steroid biochemistry and molecular biology, 2002, Volume: 82, Issue:4-5

    Topics: Androgen Antagonists; Animals; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Estradiol; Estrogen Antagonists; Female; Flutamide; Fulvestrant; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; HSP72 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Immunoenzyme Techniques; Membrane Proteins; Methyltestosterone; Mice; Organ Size; Ovariectomy; Receptors, Androgen; Receptors, Estrogen; Testosterone Congeners; Uterus

2002
Dehydroepiandrosterone sulfate induces acute vasodilation of porcine coronary arteries in vitro and in vivo.
    Journal of cardiovascular pharmacology, 2005, Volume: 46, Issue:3

    Topics: Androgen Antagonists; Animals; ATP-Binding Cassette Transporters; Coronary Circulation; Coronary Vessels; Dehydroepiandrosterone Sulfate; Echocardiography, Doppler; Endothelium, Vascular; Enzyme Inhibitors; Estradiol; Female; Flutamide; Fulvestrant; Glyburide; Hemodynamics; In Vitro Techniques; KATP Channels; Male; NG-Nitroarginine Methyl Ester; Pericardium; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Sex Characteristics; Swine; Testosterone; Vasodilation

2005
Flutamide restores cardiac function after trauma-hemorrhage via an estrogen-dependent pathway through upregulation of PGC-1.
    American journal of physiology. Heart and circulatory physiology, 2006, Volume: 290, Issue:1

    Topics: Abdominal Injuries; Animals; Aromatase; Dihydrotestosterone; Electron Transport Complex IV; Estradiol; Estrogen Antagonists; Flutamide; Fulvestrant; Heart Function Tests; Hemorrhage; Male; Myocardium; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Testosterone; Transcription Factors; Up-Regulation

2006
Estrogen and testosterone use different cellular pathways to inhibit osteoclastogenesis and bone resorption.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2005, Volume: 20, Issue:12

    Topics: Acid Phosphatase; Adult; Androgen Antagonists; Animals; Bone Resorption; Carrier Proteins; Cattle; Cell Differentiation; Cell Line, Tumor; Coculture Techniques; Dexamethasone; Dose-Response Relationship, Drug; Estradiol; Estrogen Antagonists; Estrogens; Flutamide; Fulvestrant; Glycoproteins; Humans; Isoenzymes; Lipopolysaccharide Receptors; Macrophage Colony-Stimulating Factor; Male; Membrane Glycoproteins; Monocytes; Osteoclasts; Osteoprotegerin; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; Tartrate-Resistant Acid Phosphatase; Testosterone; Tumor Necrosis Factor-alpha

2005
Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of estrogen receptor-{beta}-dependent HO-1.
    Journal of leukocyte biology, 2006, Volume: 79, Issue:2

    Topics: Animals; Chemokine CXCL1; Chemokines, CXC; Enzyme Activation; Enzyme Inhibitors; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Flutamide; Fulvestrant; Gene Expression Regulation, Enzymologic; Heme Oxygenase-1; Hemorrhage; Intercellular Adhesion Molecule-1; Intestines; Male; Mesoporphyrins; Peroxidase; Rats; Rats, Sprague-Dawley; RNA, Messenger; Up-Regulation

2006
Anti-estrogen ICI 182.780 and anti-androgen flutamide induce tyrosine phosphorylation of cortactin in the ectoplasmic specialization between the Sertoli cell and spermatids in the mouse testis.
    Biochemical and biophysical research communications, 2006, Jul-21, Volume: 346, Issue:1

    Topics: Androgen Antagonists; Animals; Cortactin; Estradiol; Estrogen Antagonists; Flutamide; Fulvestrant; Male; Mice; Mice, Inbred ICR; Phosphorylation; Sertoli Cells; Spermatids; Testis; Tyrosine

2006
Dehydroepiandrosterone improves murine osteoblast growth and bone tissue morphometry via mitogen-activated protein kinase signaling pathway independent of either androgen receptor or estrogen receptor.
    Journal of molecular endocrinology, 2007, Volume: 38, Issue:4

    Topics: Androgen Receptor Antagonists; Animals; Apoptosis; Bone and Bones; Bone Density Conservation Agents; Butadienes; Cell Cycle; Cell Proliferation; Cells, Cultured; Dehydroepiandrosterone; Estradiol; Extracellular Signal-Regulated MAP Kinases; Female; Flutamide; Fulvestrant; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Nitriles; Osteoblasts; Ovariectomy; Phosphorylation; Proliferating Cell Nuclear Antigen; Receptors, Androgen; Receptors, Estrogen

2007
The methoxychlor metabolite, HPTE, directly inhibits the catalytic activity of cholesterol side-chain cleavage (P450scc) in cultured rat ovarian cells.
    Reproductive toxicology (Elmsford, N.Y.), 2008, Volume: 25, Issue:1

    Topics: Androgen Antagonists; Animals; Benzhydryl Compounds; Catalytic Domain; Cells, Cultured; Cholesterol Side-Chain Cleavage Enzyme; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrogens; Female; Flutamide; Fulvestrant; Gene Expression Regulation, Enzymologic; Gonadotropins, Equine; Methoxychlor; Ovary; Oxazoles; Phenols; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, Androgen; Receptors, Estrogen; RNA, Messenger

2008
Potential role of G-protein-coupled receptor 30 (GPR30) in estradiol-17beta-stimulated IGF-I mRNA expression in bovine satellite cell cultures.
    Domestic animal endocrinology, 2008, Volume: 35, Issue:3

    Topics: Androgen Antagonists; Animals; Cattle; Cell Proliferation; Cyclin G; Cyclin G1; Cyclins; Estradiol; Estrogen Antagonists; Flutamide; Fulvestrant; Insulin-Like Growth Factor I; Male; Muscle, Skeletal; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Satellite Cells, Skeletal Muscle; Serum Albumin, Bovine; Trenbolone Acetate

2008
Androgen-induced human breast cancer cell proliferation is mediated by discrete mechanisms in estrogen receptor-alpha-positive and -negative breast cancer cells.
    The Journal of steroid biochemistry and molecular biology, 2009, Volume: 113, Issue:3-5

    Topics: Androgen Antagonists; Androgens; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Female; Flutamide; Fulvestrant; Humans; Integrin alphaVbeta3; Oligopeptides; Receptors, Androgen; RNA, Small Interfering

2009
Androgen- and estrogen-independent regulation of copulatory behavior following castration in male B6D2F1 mice.
    Hormones and behavior, 2009, Volume: 56, Issue:2

    Topics: Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Animals; Aromatase; Aromatase Inhibitors; Copulation; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogens; Female; Flutamide; Fulvestrant; Letrozole; Male; Mating Preference, Animal; Mice; Nitriles; Orchiectomy; Preoptic Area; Receptors, Androgen; RNA, Messenger; Septal Nuclei; Triazoles

2009
Sex differences in the analgesic effects of ICI 182,780 and Flutamide on ureteral calculosis in rats.
    Hormones and behavior, 2011, Volume: 59, Issue:1

    Topics: Analgesics; Analysis of Variance; Animals; Estradiol; Female; Flutamide; Fulvestrant; Male; Pain; Radioimmunoassay; Rats; Rats, Wistar; Sex Characteristics; Testosterone; Ureteral Calculi

2011
Cellular actions of testosterone in vascular cells: mechanism independent of aromatization to estradiol.
    Steroids, 2012, Volume: 77, Issue:11

    Topics: 5-alpha Reductase Inhibitors; Anastrozole; Androgen Antagonists; Animals; Aorta; Aromatase Inhibitors; Cell Adhesion; Cell Proliferation; Dose-Response Relationship, Drug; Endothelial Cells; Estradiol; Estrogen Antagonists; Female; Finasteride; Flutamide; Fulvestrant; Monocytes; Myocytes, Smooth Muscle; Nitric Oxide; Nitriles; Rats; Rats, Wistar; Testosterone; Triazoles

2012
Steroid regulation of early postnatal development in the corpus epididymidis of pigs.
    The Journal of endocrinology, 2015, Volume: 225, Issue:3

    Topics: Androgen Receptor Antagonists; Animals; Aromatase; Aromatase Inhibitors; Blood-Testis Barrier; Epididymis; Estradiol; Estrogen Receptor Antagonists; Flutamide; Fulvestrant; Letrozole; Male; Microscopy, Electron, Transmission; Nitriles; Protein Isoforms; Receptors, Androgen; Receptors, Estrogen; Receptors, G-Protein-Coupled; Sexual Development; Signal Transduction; Sus scrofa; Tight Junctions; Triazoles

2015
Sex Steroids Influence Brain-Derived Neurotropic Factor Secretion From Human Airway Smooth Muscle Cells.
    Journal of cellular physiology, 2016, Volume: 231, Issue:7

    Topics: Airway Remodeling; Asthma; Brain-Derived Neurotrophic Factor; Estradiol; Estrogens; Female; Flutamide; Fulvestrant; Gene Expression Regulation; Gonadal Steroid Hormones; Humans; Inflammation; Male; Membrane Glycoproteins; Myocytes, Smooth Muscle; Protein-Tyrosine Kinases; Receptor, trkB; Receptors, Androgen; Testosterone

2016
Activational action of testosterone on androgen receptors protects males preventing temporomandibular joint pain.
    Pharmacology, biochemistry, and behavior, 2017, Volume: 152

    Topics: 5-alpha Reductase Inhibitors; Androgen Antagonists; Animals; Dutasteride; Estradiol; Estrogen Receptor Antagonists; Female; Flutamide; Formaldehyde; Fulvestrant; Male; Pain; Pain Measurement; Rats; Receptors, Androgen; Temporomandibular Joint; Testosterone

2017
Testosterone-induced modulation of peroxisomal morphology and peroxisome-related gene expression in brown trout (Salmo trutta f. fario) primary hepatocytes.
    Aquatic toxicology (Amsterdam, Netherlands), 2017, Volume: 193

    Topics: Androgen Antagonists; Animals; Catalase; Down-Regulation; Endocrine Disruptors; Estradiol; Estrogen Antagonists; Flutamide; Fulvestrant; Hepatocytes; Peroxisomes; PPAR alpha; Signal Transduction; Testosterone; Trout; Up-Regulation; Urate Oxidase; Vitellogenins; Water Pollutants, Chemical

2017
Non-genomic actions of sex hormones on pregnant uterine contractility in rats: An in vitro study at term.
    Life sciences, 2020, Dec-15, Volume: 263

    Topics: Animals; Dose-Response Relationship, Drug; Estradiol; Female; Flutamide; Fulvestrant; Mifepristone; Muscle Contraction; Potassium Chloride; Pregnancy; Progesterone; Rats; Rats, Sprague-Dawley; Testosterone; Uterine Contraction

2020