fullerene-c70 has been researched along with phytochlorin* in 1 studies
1 other study(ies) available for fullerene-c70 and phytochlorin
| Article | Year |
|---|---|
Fullerene/photosensitizer nanovesicles as highly efficient and clearable phototheranostics with enhanced tumor accumulation for cancer therapy.
A novel phototheranostic platform based on tri-malonate derivative of fullerene C70 (TFC70)/photosensitizer (Chlorin e6, Ce6) nanovesicles (FCNVs) has been developed for effective tumor imaging and treatment. The FCNVs were prepared from amphiphilic TFC70-oligo ethylene glycol -Ce6 molecules. The developed FCNVs possessed the following advantages: (i) high loading efficiency of Ce6 (up to ∼57 wt%); (ii) efficient absorption in near-infrared light region; (iii) enhanced cellular uptake efficiency of Ce6 in vitro and in vivo; (iv) good biocompatibility and total clearance out from the body. These unique properties suggest that the as-prepared FCNVs could be applied as an ideal theranostic agent for simultaneous imaging and photodynamic therapy of tumor. This finding may provide a good solution to highly efficient phototheranostic applications based on fullerene derivatives fabricated nanostructures. Topics: A549 Cells; Absorption, Physicochemical; Animals; Apoptosis; Chlorophyllides; Diffusion; Female; Fullerenes; Humans; Mice; Mice, Inbred BALB C; Nanocapsules; Neoplasms, Experimental; Particle Size; Photochemotherapy; Photosensitizing Agents; Porphyrins; Tissue Distribution; Treatment Outcome | 2016 |