fti-276 and hymenialdisine

fti-276 has been researched along with hymenialdisine* in 1 studies

Other Studies

1 other study(ies) available for fti-276 and hymenialdisine

Article	Year
Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). Journal of medicinal chemistry, 2002, Jan-17, Volume: 45, Issue:2 Raf/MEK-1/MAPK cascade inhibitor activity-directed fractionation of the sponge Stylissa massa afforded eight known alkaloids: aldisine (1), 2-bromoaldisine (2), 10Z-debromohymenialdisine (3), 10E-hymenialdisine (4), 10Z-hymenialdisine (5), hymenin (6), oroidin (7), and 4,5-dibromopyrrole-2-carbonamide (8). Both 4 and 5 showed significant enzyme inhibitory activity (IC(50) 3 and 6 nM, respectively). Secondary assays identified these compounds as potent MEK-1 inhibitors. Compounds 4 and 5 also inhibited the growth of human tumor LoVo cells. Topics: Animals; Antineoplastic Agents; Azepines; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Philippines; Phosphorylation; Porifera; Protein Serine-Threonine Kinases; Pyrroles; Structure-Activity Relationship; Tumor Cells, Cultured	2002

Article

Year

Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1).

Journal of medicinal chemistry, 2002, Jan-17, Volume: 45, Issue:2

Raf/MEK-1/MAPK cascade inhibitor activity-directed fractionation of the sponge Stylissa massa afforded eight known alkaloids: aldisine (1), 2-bromoaldisine (2), 10Z-debromohymenialdisine (3), 10E-hymenialdisine (4), 10Z-hymenialdisine (5), hymenin (6), oroidin (7), and 4,5-dibromopyrrole-2-carbonamide (8). Both 4 and 5 showed significant enzyme inhibitory activity (IC(50) 3 and 6 nM, respectively). Secondary assays identified these compounds as potent MEK-1 inhibitors. Compounds 4 and 5 also inhibited the growth of human tumor LoVo cells.

Topics: Animals; Antineoplastic Agents; Azepines; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Philippines; Phosphorylation; Porifera; Protein Serine-Threonine Kinases; Pyrroles; Structure-Activity Relationship; Tumor Cells, Cultured

2002