fremy-s-salt and isocorydine

Transforming technology for semi-synthesized isocorydione from the natural product ofisocorydine was studied. The factors affecting on the reaction yield were investigated. UV spectrophotometry was used to indicate the semi-synthesized yield of isocorydione. The optimum reaction conditions were determined as following: reacting for 12 h in the solution of sodium dihydrogen phosphate at pH 10, the temperature was 25 degrees C and the ratio of isocorydine to Fremy's radical was 1 : 2. Under the optimum conditions, the yield could reach up to 50.0%. The molecular structure of isocorydione was elucidated by X-ray single-crystal diffraction analysis for the first time.

Topics: Antineoplastic Agents, Phytogenic; Aporphines; Crystallography, X-Ray; Hydrogen-Ion Concentration; Molecular Structure; Nitroso Compounds; Oxidation-Reduction; Papaveraceae; Plants, Medicinal; Spectrophotometry, Ultraviolet; Temperature; X-Ray Diffraction