Page last updated: 2024-09-05

fr 7534 and nifedipine

fr 7534 has been researched along with nifedipine in 8 studies

Compound Research Comparison

Studies
(fr 7534)
Trials
(fr 7534)
Recent Studies (post-2010)
(fr 7534)
Studies
(nifedipine)
Trials
(nifedipine)
Recent Studies (post-2010) (nifedipine)
100016,0242,4961,505

Protein Interaction Comparison

ProteinTaxonomyfr 7534 (IC50)nifedipine (IC50)
perilipin-5Homo sapiens (human)7.133
perilipin-1Homo sapiens (human)9.619
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform aHomo sapiens (human)8.376
Voltage-dependent L-type calcium channel subunit alpha-1CCavia porcellus (domestic guinea pig)0.0429
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.035
Cytochrome P450 1A2Homo sapiens (human)0.3
Cytochrome P450 3A4Homo sapiens (human)10
Adenosine receptor A3Homo sapiens (human)7.214
Cytochrome P450 2C9 Homo sapiens (human)3.06
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)10
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)7.214
Voltage-dependent L-type calcium channel subunit alpha-1CRattus norvegicus (Norway rat)0.0385
Potassium voltage-gated channel subfamily A member 5Homo sapiens (human)6.1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Rattus norvegicus (Norway rat)1.12
Adenosine receptor A1Homo sapiens (human)7.701
3-oxo-5-alpha-steroid 4-dehydrogenase 2Rattus norvegicus (Norway rat)1.12
C-C chemokine receptor type 2Homo sapiens (human)2.191
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)7.214
Cytochrome P450 2J2Homo sapiens (human)3.06
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.4733
Voltage-dependent L-type calcium channel subunit alpha-1CMus musculus (house mouse)1.2
Voltage-dependent L-type calcium channel subunit alpha-1SMus musculus (house mouse)1.2
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.035
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.0394
Myosin light chain kinase, smooth muscleHomo sapiens (human)2.02
Potassium channel subfamily K member 2 Bos taurus (cattle)8.2
Indoleamine 2,3-dioxygenase 2Mus musculus (house mouse)1.5
Voltage-dependent L-type calcium channel subunit alpha-1DMus musculus (house mouse)1.2
Voltage-dependent L-type calcium channel subunit alpha-1FMus musculus (house mouse)1.2

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19907 (87.50)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cao, S; Chang, CC; Dunne, SF; Kai, L; Kang, S; Luan, CH; Pandey, P; Silverman, RB; Surmeier, DJ; Tian, X1
Gross, GJ; Jolly, SR2
Amellal, M; Bronner, C; Kuhry, JG; Landry, Y1
Diemer, MJ; Gross, GJ; Hardman, HF; Warltier, DC1
Gross, GJ; Hardman, HF; Jolly, SR1
Gross, GJ; Jolly, SR; Menahan, LA1
Brooks, HL; Gross, GJ; Meils, CM; Warltier, DC1

Other Studies

8 other study(ies) available for fr 7534 and nifedipine

ArticleYear
Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Ca2+ channels Ca V 1.3 and Ca V 1.2.
    Bioorganic & medicinal chemistry, 2010, May-01, Volume: 18, Issue:9

    Topics: Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Line; Dicarboxylic Acids; Dihydropyridines; Humans; Inhibitory Concentration 50; Molecular Structure; Nifedipine

2010
Effect of FR 7534, a new calcium antagonist, on myocardial oxygen demand.
    European journal of pharmacology, 1979, Mar-01, Volume: 54, Issue:3

    Topics: Animals; Calcium; Dipyridamole; Dogs; Female; Hemodynamics; Male; Myocardium; Nifedipine; Nitroglycerin; Oxygen; Oxygen Consumption; Pyridines

1979
Plasma membrane fluidity studies by fluorescence polarization in rat mast cells stimulated by compound 48/80.
    Agents and actions, 1985, Volume: 16, Issue:3-4

    Topics: Animals; Calcium; Dose-Response Relationship, Drug; Fluorescence Polarization; Histamine Release; Male; Mast Cells; Membrane Fluidity; Nifedipine; p-Methoxy-N-methylphenethylamine; Rats; Rats, Inbred Strains

1985
Improvement in ischemic myocardial blood flow following a new calcium antagonist.
    The American journal of physiology, 1980, Volume: 239, Issue:2

    Topics: Animals; Calcium; Coronary Circulation; Dipyridamole; Dogs; Dose-Response Relationship, Drug; Female; Male; Microspheres; Myocardium; Nifedipine; Nitroglycerin; Oxygen Consumption; Perfusion; Pyridines; Regional Blood Flow

1980
Relaxation of potassium-depolarized canine, bovine and porcine large coronary arteries by nitroglycerin, chromonar and two dihydropyridine calcium antagonists.
    General pharmacology, 1981, Volume: 12, Issue:3

    Topics: Animals; Calcium; Cattle; Chromonar; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Male; Muscle Relaxation; Nifedipine; Nitroglycerin; Potassium; Pyridines; Swine; Vasodilator Agents

1981
Comparison of two dihydropyridine calcium antagonists on coronary collateral blood flow in acute myocardial ischemia.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 217, Issue:1

    Topics: Animals; Calcium; Collateral Circulation; Coronary Circulation; Coronary Disease; Dogs; Female; Hemodynamics; Male; Nifedipine; Oxygen Consumption; Pyridines

1981
Effects of several calcium antagonists and dipyridamole in the isolated perfused guinea pig heart.
    Life sciences, 1980, Dec-15, Volume: 27, Issue:24

    Topics: Animals; Calcium; Coronary Circulation; Dipyridamole; Gallopamil; Guinea Pigs; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Nifedipine; Oxygen Consumption; Perfusion; Pyridines; Verapamil

1980
Reduction of myocardial infarct size by the calcium antagonist fr 7534.
    Cardiology, 1981, Volume: 68, Issue:3

    Topics: Animals; Blood Pressure; Collateral Circulation; Coronary Circulation; Dogs; Heart Rate; Myocardial Infarction; Nifedipine; Pyridines

1981