fr-173657 and iminodiacetic-acid

fr-173657 has been researched along with iminodiacetic-acid* in 1 studies

Other Studies

1 other study(ies) available for fr-173657 and iminodiacetic-acid

Article	Year
Solution-phase combinatorial synthesis of nonpeptide bradykinin antagonists. Bioorganic & medicinal chemistry, 2004, Jul-01, Volume: 12, Issue:13 We describe the solution-phase combinatorial synthesis and pharmacological effect of fifty N,N(')-substituted-N"-1-(4-chlorobenzhydryl)piperazine iminodiacetic acid triamide derivatives as nonpeptide B2 antagonists. The synthesized compounds were tested for their antibradykinin activity by utilizing guinea-pig ileum smooth muscle. Most of the compounds showed antagonistic effects on bradykinin induced contraction. N-acetyl-N(')-(4-methylbenzyl)-N"-1-(4-chlorobenzhydryl)piperazine iminodiacetic acid triamide (A3B1C1) showed the 46% inhibition at 100nM. Topics: Amination; Animals; Bradykinin Receptor Antagonists; Combinatorial Chemistry Techniques; Drug Design; Guinea Pigs; Ileum; Imino Acids; Male; Molecular Structure; Muscle, Smooth; Quinolines; Receptors, Bradykinin; Solutions	2004

Article

Year

Solution-phase combinatorial synthesis of nonpeptide bradykinin antagonists.

Bioorganic & medicinal chemistry, 2004, Jul-01, Volume: 12, Issue:13

We describe the solution-phase combinatorial synthesis and pharmacological effect of fifty N,N(')-substituted-N"-1-(4-chlorobenzhydryl)piperazine iminodiacetic acid triamide derivatives as nonpeptide B2 antagonists. The synthesized compounds were tested for their antibradykinin activity by utilizing guinea-pig ileum smooth muscle. Most of the compounds showed antagonistic effects on bradykinin induced contraction. N-acetyl-N(')-(4-methylbenzyl)-N"-1-(4-chlorobenzhydryl)piperazine iminodiacetic acid triamide (A3B1C1) showed the 46% inhibition at 100nM.

Topics: Amination; Animals; Bradykinin Receptor Antagonists; Combinatorial Chemistry Techniques; Drug Design; Guinea Pigs; Ileum; Imino Acids; Male; Molecular Structure; Muscle, Smooth; Quinolines; Receptors, Bradykinin; Solutions

2004