fr 139317 has been researched along with tak 044 in 7 studies
| Studies (fr 139317) | Trials (fr 139317) | Recent Studies (post-2010) (fr 139317) | Studies (tak 044) | Trials (tak 044) | Recent Studies (post-2010) (tak 044) |
|---|---|---|---|---|---|
| 219 | 0 | 8 | 105 | 8 | 2 |
| 219 | 0 | 8 | 105 | 8 | 2 |
| 219 | 0 | 8 | 105 | 8 | 2 |
| 219 | 0 | 8 | 105 | 8 | 2 |
| 219 | 0 | 8 | 105 | 8 | 2 |
| 219 | 0 | 8 | 105 | 8 | 2 |
| 219 | 0 | 8 | 105 | 8 | 2 |
| Protein | Taxonomy | fr 139317 (IC50) | tak 044 (IC50) |
|---|---|---|---|
| Endothelin-1 receptor | Homo sapiens (human) | 0.0002 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ebara, T; Iwao, H; Kim, S; Matsuura, T; Miura, K; Yamanaka, S; Yukimura, T | 1 |
| Fukai, D; Kinoshita, M; Ohnishi, M; Tsutamoto, T; Wada, A | 1 |
| Fujimoto, K; Ge, RL; Hanaoka, M; Kaneki, T; Kobayashi, T; Koizumi, T; Kubo, K; Miyahara, T; Shibamoto, T; Yamamoto, H | 1 |
| Fujii, M; Kinoshita, M; Matsumoto, T; Ohnishi, M; Sawaki, M; Tsutamoto, T; Wada, A | 1 |
| Endoh, M; Ishii, K; Maruya, J; Norota, I; Yomogida, S | 1 |
| Goto, K | 1 |
| Chu, L; Endoh, M; Norota, I; Zhang, JX | 1 |
1 review(s) available for fr 139317 and tak 044
| Article | Year |
|---|---|
[Discovery of endothelin and its significance].
Topics: Amino Acid Sequence; Animals; Azepines; Cardiovascular Diseases; Drug Design; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Humans; Indans; Indoles; Molecular Sequence Data; Peptides, Cyclic; Pyrimidines; Receptors, Endothelin; Sulfonamides; Vasoconstriction | 2004 |
6 other study(ies) available for fr 139317 and tak 044
| Article | Year |
|---|---|
Renal vascular effects of the selective endothelin receptor antagonists in anaesthetized rats.
Topics: Animals; Azepines; Blood Pressure; Cyclooxygenase Inhibitors; Endothelin Receptor Antagonists; Enzyme Inhibitors; Ibuprofen; Indoles; Kidney; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oligopeptides; Peptides, Cyclic; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Renal Circulation; Vasoconstriction | 1997 |
Comparison of the acute effects of a selective endothelin ETA and a mixed ETA/ETB receptor antagonist in heart failure.
Topics: Aldosterone; Analysis of Variance; Animals; Atrial Natriuretic Factor; Azepines; Cardiac Pacing, Artificial; Dogs; Endothelin Receptor Antagonists; Endothelin-1; Female; Glomerular Filtration Rate; Heart Failure; Hemodynamics; Indoles; Kidney; Male; Peptides, Cyclic; Receptor, Endothelin A; Renal Plasma Flow; Sodium | 1998 |
Endothelin receptor blockade attenuates air embolization-induced pulmonary hypertension in sheep.
Topics: Animals; Azepines; Blood Gas Analysis; Embolism, Air; Endothelin Receptor Antagonists; Endothelin-1; Hemodynamics; Hypertension, Pulmonary; Indoles; Peptides, Cyclic; Pulmonary Artery; Receptor, Endothelin A; Receptor, Endothelin B; Sheep | 1999 |
Significant roles of endothelin-A- and -B-receptors in renal function in congestive heart failure.
Topics: Animals; Azepines; Dogs; Glomerular Filtration Rate; Heart Failure; Hemodynamics; Indoles; Kidney; Peptides, Cyclic; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin | 2000 |
Differential inhibition by TAK-044 of the inotropic effects of endothelin-1 and endothelin-3.
Topics: Animals; Azepines; Dose-Response Relationship, Drug; Drug Interactions; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Endothelin-3; In Vitro Techniques; Indoles; Male; Myocardial Contraction; Myocardium; Oligopeptides; Papillary Muscles; Peptides, Cyclic; Piperidines; Rabbits; Radioligand Assay; Receptor, Endothelin A; Receptor, Endothelin B | 2004 |
Receptor subtypes mediating the inotropic effects and Ca(2+) signaling induced by endothelin-1 through crosstalk with norepinephrine in canine ventricular myocardium.
Topics: Animals; Azepines; Calcium Signaling; Dogs; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Female; Heart Ventricles; Indoles; Kinetics; Male; Myocardial Contraction; Myocytes, Cardiac; Norepinephrine; Oligopeptides; Peptides, Cyclic; Piperidines; Receptor Cross-Talk; Receptors, Endothelin | 2005 |