Compounds > fr 139317
Page last updated: 2024-09-02

fr 139317 and losartan

fr 139317 has been researched along with losartan in 3 studies

Study Comparison

Studies
(fr 139317)		Trials
(fr 139317)		Recent Studies (post-2010)
(fr 139317)		Studies
(losartan)		Trials
(losartan)		Recent Studies (post-2010)
(losartan)
21908723112452118
21908723112452118
21908723112452118

Protein Interaction Comparison

ProteinTaxonomyfr 139317 (IC50)losartan (IC50)
Bile salt export pumpHomo sapiens (human)9.01
NeprilysinHomo sapiens (human)10
Cytochrome P450 2C9 Homo sapiens (human)2.882
Angiotensin-converting enzyme Homo sapiens (human)0.019
Atrial natriuretic peptide receptor 3Homo sapiens (human)0.0018
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.019
Thromboxane A2 receptor Homo sapiens (human)20
Type-1A angiotensin II receptor Rattus norvegicus (Norway rat)0.0247
cAMP-specific 3',5'-cyclic phosphodiesterase 4AHomo sapiens (human)26
Type-1B angiotensin II receptorRattus norvegicus (Norway rat)1.7366
Adenosine receptor A2aRattus norvegicus (Norway rat)0.0032
Type-1 angiotensin II receptorHomo sapiens (human)0.047
Type-1 angiotensin II receptorOryctolagus cuniculus (rabbit)0.025
Type-2 angiotensin II receptorRattus norvegicus (Norway rat)28.0029
Type-2 angiotensin II receptorHomo sapiens (human)8.0038
cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)26
cAMP-specific 3',5'-cyclic phosphodiesterase 4CHomo sapiens (human)26
cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)26
cGMP-inhibited 3',5'-cyclic phosphodiesterase BHomo sapiens (human)13
cGMP-inhibited 3',5'-cyclic phosphodiesterase AHomo sapiens (human)13
Platelet glycoprotein VIHomo sapiens (human)4
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)1.1481
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)35
Type-1 angiotensin II receptorCavia porcellus (domestic guinea pig)0.018
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)0.2884

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ishiye, M; Nakashima, M; Uematsu, T; Umemura, K1
Clayton, RA; McGrath, JC; Nally, JE; Thomson, NC; Wakelam, MJ1
Bellissant, E; Durand-Castel, X; Goineau, S; Guillo, P; Pape, D1

Other Studies

3 other study(ies) available for fr 139317 and losartan

ArticleYear
Angiotensin AT1 receptor-mediated attenuation of cardiac hypertrophy due to volume overload: involvement of endothelin.
    European journal of pharmacology, 1995, Jun-23, Volume: 280, Issue:1

    Topics: Amino Acid Sequence; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Azepines; Biphenyl Compounds; Cardiac Volume; Cardiomegaly; Endothelin Receptor Antagonists; Endothelins; Heart; Heart Ventricles; Hypertrophy, Left Ventricular; Imidazoles; Indoles; Losartan; Male; Molecular Sequence Data; Myocardium; Organ Size; Rats; Rats, Wistar; Receptors, Angiotensin; Tetrazoles; Time Factors

1995
Angiotensin II enhances responses to endothelin-1 in bovine bronchial smooth muscle.
    Pulmonary pharmacology, 1994, Volume: 7, Issue:6

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Azepines; Biphenyl Compounds; Bronchi; Cattle; Drug Synergism; Endothelins; Imidazoles; In Vitro Techniques; Indoles; Losartan; Muscle Contraction; Muscle, Smooth; Receptors, Angiotensin; Receptors, Endothelin; Tetrazoles

1994
Endothelin, but not angiotensin II, contributes to the hypoxic contractile response of large isolated pulmonary arteries in the rat.
    Fundamental & clinical pharmacology, 1999, Volume: 13, Issue:4

    Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Azepines; Bosentan; Calcium; Calcium Channel Blockers; Endothelin Receptor Antagonists; Endothelins; Endothelium, Vascular; Extracellular Space; Glycopeptides; Hypoxia; In Vitro Techniques; Indoles; Lisinopril; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Pulmonary Artery; Rats; Rats, Wistar; Sulfonamides

1999