Compounds > fr 139317
Page last updated: 2024-09-02

fr 139317 and indomethacin

fr 139317 has been researched along with indomethacin in 4 studies

Study Comparison

Studies
(fr 139317)		Trials
(fr 139317)		Recent Studies (post-2010)
(fr 139317)		Studies
(indomethacin)		Trials
(indomethacin)		Recent Studies (post-2010)
(indomethacin)
219082952718383396
219082952718383396
219082952718383396
219082952718383396

Protein Interaction Comparison

ProteinTaxonomyfr 139317 (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)12.6423
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Bile salt export pumpHomo sapiens (human)44.44
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Epidermal growth factor receptorHomo sapiens (human)10
Prostaglandin G/H synthase 1Ovis aries (sheep)0.9926
Procathepsin LHomo sapiens (human)11.8
ATP-dependent translocase ABCB1Homo sapiens (human)30
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)1.0591
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)50.05
Adenosine receptor A1Rattus norvegicus (Norway rat)164
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)24.35
Adenosine receptor A2aRattus norvegicus (Norway rat)164
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Multidrug resistance-associated protein 1 Homo sapiens (human)12.3
Prostaglandin G/H synthase 2Homo sapiens (human)8.1537
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)54.1
Prostaglandin G/H synthase 2Ovis aries (sheep)73.7305
Prostaglandin G/H synthase 2Mus musculus (house mouse)1.2653
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)301.995
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)41
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)12

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hosokawa, M; Oda, K; Okada, T; Okuma, M; Sakai, M; Takimoto, M; Tsukada, H; Ueda, S; Urade, Y1
Corder, R; Cristol, JP; Thiemermann, C; Vane, JR; Warner, TD; Wellings, RP1
Antunes, E; Boin, I; de Nucci, G; Donato, JL; Faro, R; Grassi-Kassisse, DM; Opgenorth, TJ; Withrington, PG; Zatz, R1
Antunes, E; Boin, I; de Nucci, G; Faro, R; Ferraz, JG; Grassi-Kassise, DM; Opgenorth, TJ; Withrington, PG1

Other Studies

4 other study(ies) available for fr 139317 and indomethacin

ArticleYear
Regulation of ion transport by endothelins in rat colonic mucosa: effects of an ETA antagonist (FR139317) and an ETB agonist (IRL1620).
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 273, Issue:3

    Topics: Animals; Azepines; Calcium; Chlorides; Colon; Endothelin Receptor Antagonists; Endothelins; Indoles; Indomethacin; Intestinal Mucosa; Ion Transport; Male; Peptide Fragments; Rats; Rats, Wistar; Sodium

1995
Evidence from receptor antagonists of an important role for ETB receptor-mediated vasoconstrictor effects of endothelin-1 in the rat kidney.
    British journal of pharmacology, 1994, Volume: 111, Issue:2

    Topics: Amino Acid Sequence; Anesthesia; Animals; Azepines; Blood Pressure; Endothelin Receptor Antagonists; Endothelins; In Vitro Techniques; Indoles; Indomethacin; Male; Molecular Sequence Data; Oligopeptides; Peptides, Cyclic; Rats; Rats, Wistar; Renal Circulation; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents; Viper Venoms

1994
Role of endothelin ETA and ETB receptors in the arterial vasculature of the isolated canine liver.
    Journal of cardiovascular pharmacology, 1995, Volume: 26 Suppl 3

    Topics: Animals; Arginine; Azepines; Dogs; Endothelins; Female; Hemoglobins; Hepatic Artery; In Vitro Techniques; Indoles; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Peptide Fragments; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Viper Venoms

1995
Characterization of endothelin receptors in isolated, perfused human spleen.
    Journal of cardiovascular pharmacology, 1998, Volume: 31 Suppl 1

    Topics: Adult; Azepines; Cyclooxygenase Inhibitors; Endothelin Receptor Antagonists; Endothelins; Enzyme Inhibitors; Humans; In Vitro Techniques; Indoles; Indomethacin; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptide Fragments; Perfusion; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Spleen

1998