Page last updated: 2024-09-02

fr 139317 and endothelin-1

fr 139317 has been researched along with endothelin-1 in 78 studies

Study Comparison

Studies (fr 139317)	Recent Studies (post-2010) (fr 139317)	Studies (endothelin-1)	Trials (endothelin-1)	Recent Studies (post-2010) (endothelin-1)
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394
219	8	12740	632	3394

Protein Interaction Comparison

Protein	Taxonomy	fr 139317 (IC50)	endothelin-1 (IC50)

Research

Studies (78)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	45 (57.69)	18.2507
2000's	31 (39.74)	29.6817
2010's	2 (2.56)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Davenport, AP; Maguire, JJ	2
Aghai, Z; Bax, WA; Saxena, PR; van Tricht, CL; Wassenaar, C	1
Fujita, K; Hashimoto, N; Matsumura, Y; Miyazaki, Y; Morimoto, S; Takaoka, M	1
Ando, T; Fujishima, M; Fukuda, K; Okuda, S; Tamaki, K; Yanagida, T	1
Bakken, IJ; Edvinsson, L; Elsås, T; Sjaavaag, I; Vincent, MB; White, LR	1
Iwao, H; Kim, S; Matsuura, T; Miura, K; Yukimura, T	1
Oda, K; Okada, T; Sasaki, Y; Takimoto, M	1
Hayakawa, A; Hayashi, S; Katayama, A; Kobayashi, T; Negita, M; Takagi, H; Uchida, K; Yasutomi, M; Yokoyama, I	1
Kozlowski, RZ; Salter, KJ	1
deWit, D; Gerard, RD; Niranjan, V; Télémaque, S; Yanagisawa, M	1
Atkinson, JB; Forman, MB; Holsinger, JP; Jackson, EK; Kawana, M; Murray, JJ; Quertermous, T; Vitola, JV	1
Andriuoli, G; Calignano, A; Cirino, G; Pinto, A; Sorrentino, L	1
Allcock, GH; Warner, TD	1
Chiou, WJ; Dixon, DB; Opgenorth, TJ; Wu-Wong, JR	1
Ebihara, I; Koide, H; Nakamura, T; Tomino, Y	1
Filep, JG	2
Kratzberg, YP; Nguyen, TH; Ohta, M; Pai, R; Sarfeh, IJ; Sugimachi, K; Tarnawski, AS	1
Hasdai, D; Holmes, DR; Katusic, ZS; Lerman, A; Mathew, V; Schwartz, RS; Smith, LA	1
D'Amico, M; Di Filippo, C; Rossi, F	2
Best, PJ; Cannan, CR; Hasdai, D; Holmes, DR; Lerman, A; Mathew, V; Schwartz, RS	1
Agabiti-Rosei, E; Bettoni, G; Castellano, M; Pasini, G; Piccoli, A; Porteri, E; Rizzoni, D	1
MacLean, MM; Mullaney, I; Vaughan, DM	1
Aihara, M; Inoue, H; Ishida, H; Tomioka, M	1
deWit, D; Emoto, N; Télémaque, S; Yanagisawa, M	1
Docherty, C; MacLean, MR	1
Azuma, S; Fujita, K; Hashimoto, N; Kuro, T; Matsumura, Y	1
Aasly, J; Adner, M; Cappelen, J; Edvinsson, L; Juul, R; Leseth, KH; White, LR	1
Asazuma, K; Eguchi, K; Hayashi, T; Kato, H; Koshino, Y; Matsukawa, S; Miyamori, I; Nakai, T	1
Kamikawa, Y; Uchida, K; Yuzuki, R	1
Hisa, H; Matsui, T; Ono, N; Satoh, S; Suzuki-Kusaba, M; Yoshida, M	1
Fukai, D; Kinoshita, M; Ohnishi, M; Tsutamoto, T; Wada, A	1
Fukai, D; Kinoshita, M; Maeda, Y; Ohnishi, M; Sawaki, M; Tsutamoto, T; Wada, A	1
Furukawa, K; Inaba, S; Mabuchi, H; Miyamori, I; Takeda, Y	1
Chilian, WM; DeFily, DV; Nishikawa, Y	1
Desmarets, J; Frelin, C	1
Arai, K; Hatano, A; Komeyama, T; Mizusawa, T; Obara, K; Okamoto-Koizumi, T; Takahashi, K; Takeda, M; Tamaki, M; Tomita, Y; Tsutsui, T	1
Endoh, M; Kayama, T; Maruya, J; Norota, I; Sato, M; Takemura, S	1
Henry, PJ; King, SH	1
D'Amico, M; Di Filippo, C; Esposito, F; Filippelli, A; Rossi, F	1
D'Amico, M; Di Filippo, C; Filippelli, A; Rossi, F	1
Butcher, SP; Henshall, DC; Sharkey, J	1
Fujimoto, K; Ge, RL; Hanaoka, M; Kaneki, T; Kobayashi, T; Koizumi, T; Kubo, K; Miyahara, T; Shibamoto, T; Yamamoto, H	1
Endoh, M; Watanabe, T	1
D'Agostino, B; Di Pierro, P; Falciani, M; Filippelli, A; Gallelli, L; Rossi, F	1
MacLean, MR; Mullaney, I; Vaughan, DM	1
Edvinsson, L; Hansen-Schwartz, J	1
Gebke, E; Gerstberger, R; Müller, AR; Pehl, U	1
Abe, Y; Isaka, M; Kitazawa, T; Takaoka, K; Taneike, T; Yamada, Y	1
Hisa, H; Hosokawa, A; Kimura, T; Nagayama, T; Satoh, S; Suzuki-Kusaba, M; Yoshida, M	1
Fukushima, Y; Hisa, H; Kimura, T; Kuwakubo, F; Matsumoto, T; Matsumura, Y; Nagayama, T; Satoh, S; Suzuki-Kusaba, M; Yoshida, M	1
Araki, M; Fujita, M; Hasegawa, K; Iwai-Kanai, E; Kakita, T; Morimoto, T; Sasayama, S; Sawamura, T; Wada, H	1
de Vries, R; Edvinsson, L; Saetrum Opgaard, O; Saxena, PR; Tom, B	1
Breuiller-Fouché, M; Chapron, C; Ferré, F; Honoré, JC; Robert, B; Vacher-Lavenu, MC	1
Kita, S; Matsumura, Y; Okui, T	1
Li, B; Morioka, T; Oite, T; Yao, J	1
Fukui, H; Imazu, H; Kojima, H; Kuriyama, S; Nakatani, Y; Sakurai, S; Uemura, M; Yamao, J; Yoshiji, H	1
Adner, M; Edvinsson, L; Shankley, N	1
Schipke, J; Schmitz-Spanke, S	1
Endoh, M; Wang, H	1
Hishida, A; Kato, A	1
Edvinsson, L; Hansen-Schwartz, J; Szok, D	1
Chen, XC; Fang, C; Liu, YM; Luo, NS; Wu, W; Zhang, XM	1
Leung, SW; Lim, SL; Man, RY; Pang, CC	1
D'Amico, M; Di Filippo, C; Filippelli, A; Piegari, E; Rinaldi, B; Rossi, F	1
D'Amico, M; Di Filippo, C; Esposito, F; Filippelli, A; Piegari, E; Rinaldi, B; Rossi, F	1
D'Amico, M; Di Filippo, C; Getting, SJ; Lam, CW; Rossi, F	1
D'Amico, M; Del Soldato, P; Di Filippo, C; Ongini, E; Perretti, M; Rossi, F	1
Endoh, M; Ishii, K; Maruya, J; Norota, I; Yomogida, S	1
Edvinsson, L; Granström, B; Hultkvist-Bengtsson, U; Nilsson, E	1
Goto, K	1
Chu, L; Endoh, M; Norota, I; Zhang, JX	1
Edvinsson, L; Johnsson, E; Maddahi, A; Wackenfors, A	1
Chen, HI; Hsieh, NK; Liu, DD; Yang, YL	1
Clark, JC; Davenport, AP; Fryer, TD; Johnström, P; Maguire, JJ; Pickard, JD; Richards, HK	1
Bratz, IN; Damron, DS; Guarini, G; Haney, RM; Meszaros, JG; Ohanyan, VA; Raman, P; Talasila, PK; Thodeti, CK	1

Reviews

1 review(s) available for fr 139317 and endothelin-1

Article	Year
[Discovery of endothelin and its significance]. Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 9 Topics: Amino Acid Sequence; Animals; Azepines; Cardiovascular Diseases; Drug Design; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Humans; Indans; Indoles; Molecular Sequence Data; Peptides, Cyclic; Pyrimidines; Receptors, Endothelin; Sulfonamides; Vasoconstriction	2004

Article

Year

[Discovery of endothelin and its significance].

Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 9

Topics: Amino Acid Sequence; Animals; Azepines; Cardiovascular Diseases; Drug Design; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Humans; Indans; Indoles; Molecular Sequence Data; Peptides, Cyclic; Pyrimidines; Receptors, Endothelin; Sulfonamides; Vasoconstriction

2004

Other Studies

77 other study(ies) available for fr 139317 and endothelin-1

Article	Year
ETA receptor-mediated constrictor responses to endothelin peptides in human blood vessels in vitro. British journal of pharmacology, 1995, Volume: 115, Issue:1 Topics: Adolescent; Adult; Blood Vessels; Endothelins; Endothelium, Vascular; Female; Humans; In Vitro Techniques; Male; Middle Aged; Peptides; Receptors, Endothelin; Signal Transduction; Vasoconstriction; Vasoconstrictor Agents; Viper Venoms	1995
Different endothelin receptors involved in endothelin-1- and sarafotoxin S6B-induced contractions of the human isolated coronary artery. British journal of pharmacology, 1994, Volume: 113, Issue:4 Topics: Adolescent; Adult; Azepines; Child; Child, Preschool; Coronary Vessels; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Endothelium, Vascular; Female; Glycopeptides; Humans; In Vitro Techniques; Indoles; Infant; Male; Middle Aged; Muscle Contraction; Muscle, Smooth, Vascular; Peptides, Cyclic; Protease Inhibitors; Protein Precursors; Receptors, Endothelin; Vasoconstrictor Agents; Viper Venoms	1994
ETA receptor-mediated role of endothelin in the kidney of DOCA-salt hypertensive rats. Life sciences, 1996, Volume: 58, Issue:1 Topics: Animals; Azepines; Blood Pressure; Blotting, Northern; Body Weight; Desoxycorticosterone; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Hypertension, Renovascular; Indoles; Kidney; Male; Organ Size; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin; Renal Circulation; RNA, Messenger	1996
Role of endothelin as a mitogen in experimental glomerulonephritis in rats. Kidney international, 1996, Volume: 49, Issue:5 Topics: Animals; Azepines; Base Sequence; Cell Division; Disease Models, Animal; DNA Primers; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Glomerular Mesangium; Glomerulonephritis, Membranoproliferative; In Situ Hybridization; Indoles; Macrophages; Male; Mitogens; Molecular Sequence Data; Monocytes; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin; RNA, Messenger	1996
Vasoactivity mediated by endothelin ETA and ETB receptors in isolated porcine ophthalmic artery. Acta physiologica Scandinavica, 1996, Volume: 157, Issue:2 Topics: Animals; Azepines; Bosentan; Dinoprost; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-3; In Vitro Techniques; Indoles; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Ophthalmic Artery; Receptors, Endothelin; Sulfonamides; Swine; Vasoconstrictor Agents; Viper Venoms	1996
Selective blockade of endothelin receptor subtypes on systemic and renal vascular responses to endothelin-1 and IRL1620, a selective endothelin ETB-receptor agonist, in anesthetized rats. Japanese journal of pharmacology, 1996, Volume: 71, Issue:3 Topics: Anesthesia; Animals; Azepines; Blood Pressure; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Indoles; Male; Oligopeptides; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Renal Circulation	1996
Endothelin-A receptor-mediated prostanoid secretion via autocrine and deoxyribonucleic acid synthesis via paracrine signaling in human bronchial epithelial cells. Endocrinology, 1996, Volume: 137, Issue:11 Topics: Azepines; Blood; Bronchi; Calcium; Cells, Cultured; Culture Media; DNA; Endothelin-1; Endothelin-3; Epithelial Cells; Epithelium; Humans; Indoles; Isoenzymes; Kinetics; Nitric Oxide Synthase; Nitrites; Prostaglandins; Receptor, Endothelin A; Receptors, Endothelin; Signal Transduction; Substrate Specificity; Thymidine	1996
Endothelin-1 and in vitro evidence of renal artery vasoconstriction after liver transplantation. Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1995, Volume: 195, Issue:6 Topics: Animals; Azepines; Endothelin Receptor Antagonists; Endothelin-1; Indoles; Ischemia; Isometric Contraction; Liver Transplantation; Renal Artery; Reperfusion; Swine; Urea; Vasoconstriction	1995
Endothelin receptor coupling to potassium and chloride channels in isolated rat pulmonary arterial myocytes. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 279, Issue:2 Topics: Animals; Azepines; Calcium; Chloride Channels; Dose-Response Relationship, Drug; Endothelin-1; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Indoles; Male; Muscle, Smooth, Vascular; Potassium Channels; Pulmonary Artery; Rats; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin	1996
Systemic hypertension induced by hepatic overexpression of human preproendothelin-1 in rats. The Journal of clinical investigation, 1996, Nov-15, Volume: 98, Issue:10 Topics: Adenoviruses, Human; Animals; Azepines; Blood Pressure; Blotting, Northern; Cytomegalovirus; DNA, Complementary; Endothelin-1; Escherichia coli; Gene Expression Regulation; Genetic Vectors; Humans; Hypertension; Indoles; Kidney; Lac Operon; Liver; Male; Oligopeptides; Piperidines; Promoter Regions, Genetic; Rats; Recombination, Genetic; RNA, Messenger	1996
Role of endothelin in a rabbit model of acute myocardial infarction: effects of receptor antagonists. Journal of cardiovascular pharmacology, 1996, Volume: 28, Issue:6 Topics: Animals; Azepines; Endothelin Receptor Antagonists; Endothelin-1; Heart; Hemodynamics; Indoles; Male; Myocardial Reperfusion Injury; Myocardium; Oligopeptides; Rabbits; Receptors, Endothelin; RNA, Messenger	1996
Fluoroaluminate induces rapid release of endothelin-1 in the isolated perfused arterial and venous vessels of the rat mesentery. General pharmacology, 1997, Volume: 28, Issue:3 Topics: Aluminum; Animals; Azepines; Endothelin Receptor Antagonists; Endothelin-1; Fluorine; Indoles; Male; Mesenteric Arteries; Mesenteric Veins; Oligopeptides; Perfusion; Rats; Rats, Wistar; Type C Phospholipases	1997
Activation of ET(A) receptors is partially responsible for the rapid increase in haematocrit induced by bacterial lipopolysaccharide in the rat. Life sciences, 1997, Volume: 60, Issue:19 Topics: Animals; Azepines; Blood Pressure; Endothelin Receptor Antagonists; Endothelin-1; Hematocrit; Indoles; Lipopolysaccharides; Male; Oligopeptides; Rats; Rats, Wistar; Receptor, Endothelin A; Receptors, Endothelin	1997
Endothelin receptor antagonists: effect of serum albumin on potency and comparison of pharmacological characteristics. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 281, Issue:2 Topics: Acetamides; Animals; Atrasentan; Azepines; Binding, Competitive; Bosentan; Cells, Cultured; CHO Cells; Cricetinae; Dioxoles; Endothelin Receptor Antagonists; Endothelin-1; Hydrolysis; Indoles; Phosphatidylinositols; Pyrrolidines; Rats; Serum Albumin, Bovine; Sulfonamides; Swine	1997
Effect of a specific endothelin receptor A antagonist and an angiotensin-converting enzyme inhibitor on glomerular mRNA levels for extracellular matrix components, metalloproteinases (MMP) and a tissue inhibitor of MMP in aminonucleoside nephrosis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1997, Volume: 12, Issue:5 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Azepines; Enalapril; Endothelin Receptor Antagonists; Endothelin-1; Extracellular Matrix; Gelatinases; Glycoproteins; Indoles; Kidney Glomerulus; Male; Matrix Metalloproteinase 2; Metalloendopeptidases; Nephrosis; Protease Inhibitors; Proteinuria; Puromycin Aminonucleoside; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; RNA, Messenger; Tissue Inhibitor of Metalloproteinases	1997
Endogenous endothelin modulates blood pressure, plasma volume, and albumin escape after systemic nitric oxide blockade. Hypertension (Dallas, Tex. : 1979), 1997, Volume: 30, Issue:1 Pt 1 Topics: Analysis of Variance; Animals; Antihypertensive Agents; Azepines; Blood Pressure; Bosentan; Data Interpretation, Statistical; Endothelin Receptor Antagonists; Endothelin-1; Hydralazine; Indoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Plasma Volume; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Serum Albumin; Sulfonamides; Time Factors; Vasodilator Agents	1997
Overexpression of endothelin-1 mRNA and protein in portal hypertensive gastric mucosa of rats: a key to increased susceptibility to damage? Surgery, 1997, Volume: 122, Issue:5 Topics: Animals; Azepines; Endothelin Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Ethanol; Gastric Mucosa; Glyceraldehyde-3-Phosphate Dehydrogenases; Hemodynamics; Hypertension, Portal; Indoles; Necrosis; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; RNA, Messenger; Transcription, Genetic; Veins; Venules	1997
Enhanced endothelin-B-receptor-mediated vasoconstriction of small porcine coronary arteries in diet-induced hypercholesterolemia. Arteriosclerosis, thrombosis, and vascular biology, 1997, Volume: 17, Issue:11 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Azepines; Cholesterol, Dietary; Coronary Vessels; Diet, Atherogenic; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Endothelium, Vascular; Female; Hypercholesterolemia; Indoles; Lipids; Oligopeptides; Piperidines; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Swine; Vasoconstriction; Vasoconstrictor Agents; Viper Venoms	1997
Selective and non-selective ET antagonists reveal an ET(A)/ET(B) receptor mediated ET-1-induced antinociceptive effect in PAG area of mice. Life sciences, 1997, Volume: 61, Issue:25 Topics: Analgesics; Animals; Azepines; Bosentan; Endothelin Receptor Antagonists; Endothelin-1; Indoles; Male; Mice; Periaqueductal Gray; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Sulfonamides	1997
Acute endothelin-receptor inhibition does not attenuate acetylcholine-induced coronary vasoconstriction in experimental hypercholesterolemia. Arteriosclerosis, thrombosis, and vascular biology, 1998, Volume: 18, Issue:1 Topics: Acetylcholine; Animals; Antihypertensive Agents; Azepines; Blood Pressure; Bosentan; Cholesterol; Coronary Vessels; Diet, Atherogenic; Endothelin Receptor Antagonists; Endothelin-1; Hemodynamics; Hypercholesterolemia; Indoles; Receptors, Endothelin; Sulfonamides; Swine; Vasoconstriction; Vasoconstrictor Agents; Viper Venoms	1998
The vasoconstriction induced by endothelin-1 is mediated only by ET(A) receptors in mesenteric small resistance arteries of spontaneously hypertensive rats and Wistar Kyoto rats. Journal of hypertension, 1997, Volume: 15, Issue:12 Pt 2 Topics: Animals; Azepines; Dose-Response Relationship, Drug; Endothelin-1; Endothelins; Hypertension; Indoles; Mesenteric Arteries; Muscle, Smooth, Vascular; Peptide Fragments; Rats; Rats, Inbred SHR; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Vascular Resistance; Vasoconstriction	1997
Endothelin-1 modulation of cAMP in rat pulmonary arteries: effect of chronic hypoxia. Journal of cardiovascular pharmacology, 1998, Volume: 31 Suppl 1 Topics: Animals; Azepines; Chronic Disease; Cyclic AMP; Endothelin Receptor Antagonists; Endothelin-1; Hypoxia; Indoles; Male; Pulmonary Artery; Rats; Rats, Wistar; Signal Transduction	1998
Changes in endothelin-1, 6-keto-PG-F1 alpha, and TX-B2 in random pattern flaps. Journal of cardiovascular pharmacology, 1998, Volume: 31 Suppl 1 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Azepines; Eicosanoids; Endothelin Receptor Antagonists; Endothelin-1; Indoles; Male; Necrosis; Rats; Rats, Wistar; Receptor, Endothelin A; Skin; Thromboxane B2	1998
In vivo role of endothelin-converting enzyme-1 as examined by adenovirus-mediated overexpression in rats. Journal of cardiovascular pharmacology, 1998, Volume: 31 Suppl 1 Topics: Adenoviridae Infections; Animals; Aspartic Acid Endopeptidases; Azepines; Blood Pressure; Cattle; DNA, Complementary; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Humans; Hypertension; Indoles; Male; Metalloendopeptidases; Organophosphonates; Protease Inhibitors; Protein Precursors; Rats; Rats, Wistar; Receptor, Endothelin A; Tetrazoles	1998
Depressor responses to endothelin-1 into the superior colliculus of rats: predominant role of endothelin ET(B) receptors. European journal of pharmacology, 1998, Apr-17, Volume: 347, Issue:1 Topics: Animals; Autoradiography; Azepines; Blood Pressure; Endothelin Receptor Antagonists; Endothelin-1; Heart Rate; Indans; Indoles; Male; Microinjections; Oligopeptides; Piperidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Superior Colliculi	1998
Development of endothelin receptors in perinatal rabbit pulmonary resistance arteries. British journal of pharmacology, 1998, Volume: 124, Issue:6 Topics: Acetylcholine; Animals; Azepines; Endothelin-1; In Vitro Techniques; Indans; Indoles; Norepinephrine; Oligopeptides; Piperidines; Potassium Chloride; Pulmonary Artery; Rabbits; Receptors, Endothelin; Serotonin; Vascular Resistance; Viper Venoms	1998
Endothelin ET(B) receptor-mediated action on systemic and renal hemodynamics and urine formation in deoxycorticosterone acetate-salt-induced hypertensive rats. Biological & pharmaceutical bulletin, 1998, Volume: 21, Issue:8 Topics: Animals; Azepines; Desoxycorticosterone; Endothelin-1; Hemodynamics; Hypertension; Indoles; Kidney; Male; Oligopeptides; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin B; Receptors, Endothelin; Urination	1998
Increased endothelin ETB contractile activity in cultured segments of human temporal artery. Acta physiologica Scandinavica, 1998, Volume: 164, Issue:1 Topics: Azepines; Bosentan; Dose-Response Relationship, Drug; Endothelin-1; Endothelin-3; Humans; Indoles; Muscle, Smooth, Vascular; Oligopeptides; Organ Culture Techniques; Piperidines; Receptor, Endothelin B; Receptors, Endothelin; Sulfonamides; Temporal Arteries; Vasoconstriction; Vasoconstrictor Agents; Viper Venoms	1998
Dexamethasone modulates the expression of endothelin-1 and -A receptors in A7r5 vascular smooth muscle cells. Journal of cardiovascular pharmacology, 1998, Volume: 32, Issue:4 Topics: Animals; Azepines; Binding Sites; Calcium; Cells, Cultured; Dexamethasone; Down-Regulation; Endothelin Receptor Antagonists; Endothelin-1; Glucocorticoids; Indoles; Muscle, Smooth, Vascular; Rats; Receptors, Endothelin; RNA, Messenger	1998
Pharmacological characterization of endothelin-induced contraction in the guinea-pig oesophageal muscularis mucosae. British journal of pharmacology, 1998, Volume: 125, Issue:4 Topics: Animals; Azepines; Calcium Channels; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-2; Endothelin-3; Endothelins; Esophagus; Guinea Pigs; Humans; Imidazoles; Indoles; Male; Muscle Contraction; Muscle, Smooth; Peptides, Cyclic; Receptors, Endothelin; Viper Venoms	1998
Renal effects of endothelin in anesthetized rabbits. European journal of pharmacology, 1998, Oct-23, Volume: 359, Issue:2-3 Topics: Analysis of Variance; Anesthesia; Animals; Azepines; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Glomerular Filtration Rate; Hydrazines; Indoles; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Oligopeptides; Piperidines; Rabbits; Receptor, Endothelin A; Receptor, Endothelin B; Renal Circulation; Sodium; Urination	1998
Comparison of the acute effects of a selective endothelin ETA and a mixed ETA/ETB receptor antagonist in heart failure. Cardiovascular research, 1998, Volume: 39, Issue:3 Topics: Aldosterone; Analysis of Variance; Animals; Atrial Natriuretic Factor; Azepines; Cardiac Pacing, Artificial; Dogs; Endothelin Receptor Antagonists; Endothelin-1; Female; Glomerular Filtration Rate; Heart Failure; Hemodynamics; Indoles; Kidney; Male; Peptides, Cyclic; Receptor, Endothelin A; Renal Plasma Flow; Sodium	1998
Effects of a specific endothelin-converting enzyme inhibitor on cardiac, renal, and neurohumoral functions in congestive heart failure: comparison of effects with those of endothelin A receptor antagonism. Circulation, 1999, Feb-02, Volume: 99, Issue:4 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Azepines; Blood Pressure; Dogs; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Female; Heart; Heart Failure; Hemodynamics; Indoles; Kidney; Male; Neuropeptides; Pulmonary Wedge Pressure; Receptor, Endothelin A; Tetracyclines; Time Factors; Vascular Resistance	1999
Mechanisms of FK 506-induced hypertension in the rat. Hypertension (Dallas, Tex. : 1979), 1999, Volume: 33, Issue:1 Topics: Animals; Aorta, Abdominal; Aspartic Acid Endopeptidases; Azepines; Base Sequence; Blood Pressure; Blotting, Southern; Data Interpretation, Statistical; DNA, Complementary; Endothelin-1; Endothelin-Converting Enzymes; Hypertension; Immunosuppressive Agents; Indoles; Kidney; Male; Mesenteric Artery, Superior; Metalloendopeptidases; Molecular Sequence Data; Natriuretic Peptide, C-Type; Nitric Oxide Synthase; Polymerase Chain Reaction; Rats; Rats, Inbred WKY; RNA, Messenger; Tacrolimus	1999
Endothelin antagonists block alpha1-adrenergic constriction of coronary arterioles. The American journal of physiology, 1999, Volume: 276, Issue:3 Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Arterioles; Azepines; Coronary Vessels; Dogs; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Glycopeptides; Hemodynamics; Indoles; Phenylephrine; Propranolol; Receptor, Endothelin A; Vasoconstriction	1999
High affinity interaction of endothelin-3 with recombinant ETA receptors. Biochemical and biophysical research communications, 1999, Mar-16, Volume: 256, Issue:2 Topics: Animals; Azepines; Binding, Competitive; Cattle; Cell Line; Cell Membrane; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-3; Endothelins; Indoles; Kinetics; Ligands; Peptide Fragments; Peptides, Cyclic; Protein Isoforms; Rats; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Recombinant Proteins; Transfection; Tyrosine; Viper Venoms	1999
Pharmacological and molecular biological evidence for ETA endothelin receptor subtype mediating mechanical responses in the detrusor smooth muscle of the human urinary bladder. Clinical science (London, England : 1979), 1999, Volume: 96, Issue:4 Topics: Aged; Azepines; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Gene Expression; Humans; Indoles; Isometric Contraction; Male; Muscle, Smooth; Peptide Fragments; Receptors, Endothelin; Reverse Transcriptase Polymerase Chain Reaction; Urinary Bladder; Viper Venoms	1999
Differential regulation of intracellular Ca2+ signalling induced by high K+ and endothelin-1 in single smooth muscle cells of intact canine basilar artery: detection by means of confocal laser microscopy. Life sciences, 1999, Volume: 64, Issue:12 Topics: Animals; Azepines; Basilar Artery; Calcium Signaling; Dogs; Endothelin-1; Female; Indoles; Male; Microscopy, Confocal; Muscle, Smooth, Vascular; Potassium	1999
Typical endothelin ETA receptors mediate atypical endothelin-1-induced contractions in sheep isolated tracheal smooth muscle. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:3 Topics: Animals; Azepines; Binding, Competitive; Endothelin Receptor Antagonists; Endothelin-1; In Vitro Techniques; Indoles; Kinetics; Muscle Contraction; Muscle, Smooth; Peptides, Cyclic; Radioligand Assay; Receptor, Endothelin A; Receptors, Endothelin; Sheep; Trachea; Vasoconstrictor Agents; Viper Venoms	1999
Injection of endothelin-1 into the raphe obscurus of rats induces depressor responses predominantly through endothelin ET(A) receptors. Naunyn-Schmiedeberg's archives of pharmacology, 1999, Volume: 359, Issue:6 Topics: Animals; Autoradiography; Azepines; Blood Pressure; Depression, Chemical; Endothelin Receptor Antagonists; Endothelin-1; Indans; Indoles; Male; Microinjections; Oligopeptides; Piperidines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin	1999
Endothelin receptor antagonists reduce the pressor effects of angiotensin II into the periaqueductal gray area of rats. Life sciences, 1999, Volume: 65, Issue:9 Topics: Angiotensin II; Animals; Azepines; Blood Pressure; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Indans; Indoles; Male; Oligopeptides; Periaqueductal Gray; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin	1999
A rat model of endothelin-3-induced middle cerebral artery occlusion with controlled reperfusion. Brain research, 1999, Oct-02, Volume: 843, Issue:1-2 Topics: Animals; Azepines; Blood Glucose; Blood Pressure; Brain; Carbon Dioxide; Cerebrovascular Circulation; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-3; Indoles; Ischemic Attack, Transient; Male; Microinjections; Middle Cerebral Artery; Oxygen; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Reperfusion	1999
Endothelin receptor blockade attenuates air embolization-induced pulmonary hypertension in sheep. European journal of pharmacology, 1999, Dec-03, Volume: 385, Issue:2-3 Topics: Animals; Azepines; Blood Gas Analysis; Embolism, Air; Endothelin Receptor Antagonists; Endothelin-1; Hemodynamics; Hypertension, Pulmonary; Indoles; Peptides, Cyclic; Pulmonary Artery; Receptor, Endothelin A; Receptor, Endothelin B; Sheep	1999
Characterization of the endothelin-1-induced regulation of L-type Ca2+ current in rabbit ventricular myocytes. Naunyn-Schmiedeberg's archives of pharmacology, 1999, Volume: 360, Issue:6 Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic beta-Agonists; Animals; Azepines; Calcium; Calcium Channels, L-Type; Cells, Cultured; Endothelin Receptor Antagonists; Endothelin-1; Heart Ventricles; In Vitro Techniques; Indoles; Isoproterenol; Male; Myocardium; Patch-Clamp Techniques; Pertussis Toxin; Phosphodiesterase Inhibitors; Protein Kinase C; Rabbits; Receptor, Endothelin A; Receptor, Endothelin B; Virulence Factors, Bordetella	1999
Endothelin-1 induced bronchial hyperresponsiveness in the rabbit: an ET(A) receptor-mediated phenomenon. Naunyn-Schmiedeberg's archives of pharmacology, 1999, Volume: 360, Issue:6 Topics: Administration, Inhalation; Airway Resistance; Animals; Antihypertensive Agents; Azepines; Bosentan; Bronchi; Bronchoconstriction; Endothelin Receptor Antagonists; Endothelin-1; Female; Histamine; Indoles; Male; Muscle, Smooth; Rabbits; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Respiratory Hypersensitivity; Sulfonamides; Vasoconstrictor Agents; Viper Venoms	1999
Role for endogenous endothelin in the regulation of plasma volume and albumin escape during endotoxin shock in conscious rats. British journal of pharmacology, 2000, Volume: 129, Issue:5 Topics: Animals; Azepines; Bacterial Toxins; Blood Pressure; Bosentan; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Enterotoxins; Erythrocyte Volume; Escherichia coli Proteins; Indoles; Lipopolysaccharides; Male; Plasma Volume; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Regional Blood Flow; Serum Albumin; Serum Albumin, Radio-Iodinated; Shock, Septic; Sulfonamides	2000
Regional modulation of cyclic nucleotides by endothelin-1 in rat pulmonary arteries: direct activation of G(i)2-protein in the main pulmonary artery. British journal of pharmacology, 2000, Volume: 129, Issue:5 Topics: Adenosine Diphosphate Ribose; Animals; Azepines; Cell Membrane; Cholera Toxin; Cyclic AMP; Cyclic GMP; Endothelin Receptor Antagonists; Endothelin-1; Endothelium, Vascular; GTP-Binding Protein alpha Subunits, Gi-Go; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle, Smooth, Vascular; Oligopeptides; Piperidines; Pulmonary Artery; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Signal Transduction	2000
Increased sensitivity to ET-1 in rat cerebral arteries following organ culture. Neuroreport, 2000, Feb-28, Volume: 11, Issue:3 Topics: Animals; Azepines; Basilar Artery; Biphenyl Compounds; Dipeptides; Endothelin Receptor Antagonists; Endothelin-1; Indoles; Organ Culture Techniques; Rats; Rats, Inbred WKY; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Vasoconstriction; Vasoconstrictor Agents; Viper Venoms	2000
Astrocytes in sensory circumventricular organs of the rat brain express functional binding sites for endothelin. Neuroscience, 2000, Volume: 97, Issue:2 Topics: Animals; Astrocytes; Autoradiography; Azepines; Cell Membrane; Cells, Cultured; Cerebral Ventricles; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-3; Indoles; Iodine Radioisotopes; Kinetics; Male; Neuroglia; Neurons; Peptides, Cyclic; Radioligand Assay; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin	2000
Characterization of functional endothelin receptors in the porcine myometrium. Peptides, 2000, Volume: 21, Issue:4 Topics: Animals; Azepines; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-3; Endothelins; Female; In Vitro Techniques; Indoles; Iodine Radioisotopes; Myometrium; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Piperidines; Radioligand Assay; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Reverse Transcriptase Polymerase Chain Reaction; Swine; Uterine Contraction; Vasoconstrictor Agents; Viper Venoms	2000
Facilitation and inhibition by endothelin-1 of adrenal catecholamine secretion in anesthetized dogs. European journal of pharmacology, 2000, May-26, Volume: 397, Issue:1 Topics: Adrenal Glands; Anesthesia; Animals; Azepines; Blood Pressure; Catecholamines; Dogs; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Epinephrine; Female; Heart Rate; Indoles; Male; Norepinephrine; Oligopeptides; Piperidines; Receptor, Endothelin A; Receptor, Endothelin B; Regional Blood Flow; Splanchnic Nerves	2000
Role of endogenous endothelins in catecholamine secretion in the rat adrenal gland. European journal of pharmacology, 2000, Oct-06, Volume: 406, Issue:1 Topics: Adrenal Glands; Animals; Azepines; Catecholamines; Dose-Response Relationship, Drug; Electric Stimulation; Endothelin-1; Endothelins; Epinephrine; Glycopeptides; In Vitro Techniques; Indoles; Male; Norepinephrine; Oligopeptides; Piperidines; Rats; Rats, Wistar	2000
Endothelin-1 as a protective factor against beta-adrenergic agonist-induced apoptosis in cardiac myocytes. Journal of the American College of Cardiology, 2000, Volume: 36, Issue:4 Topics: Adrenergic beta-Agonists; Animals; Animals, Newborn; Anti-Bacterial Agents; Apoptosis; Azepines; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Flavonoids; Heart; Indoles; Isoproterenol; Myocardium; Oligopeptides; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Sirolimus	2000
Inotropic effects of endothelin compared to noradrenaline in porcine myocardial trabeculae. Journal of cardiovascular pharmacology, 2000, Volume: 36, Issue:5 Suppl 1 Topics: Animals; Azepines; Dose-Response Relationship, Drug; Endothelin-1; Endothelin-3; Endothelins; Female; Indoles; Myocardial Contraction; Norepinephrine; Peptide Fragments; Swine	2000
No alteration in vasoconstrictor endothelin-B-receptor density or function in human coronary artery disease. Journal of cardiovascular pharmacology, 2000, Volume: 36, Issue:5 Suppl 1 Topics: Adult; Azepines; Coronary Disease; Coronary Vessels; Endothelin-1; Female; Humans; Indoles; Male; Middle Aged; Receptor, Endothelin B; Receptors, Endothelin; Vasoconstriction	2000
Expression of endothelin receptors in human myometrium during pregnancy and in uterine leiomyomas. Journal of cardiovascular pharmacology, 2000, Volume: 36, Issue:5 Suppl 1 Topics: Azepines; Endothelin-1; Female; Humans; Indoles; Leiomyoma; Myometrium; Oligopeptides; Piperidines; Pregnancy; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; RNA, Messenger; Uterine Neoplasms	2000
Potentiation by endothelin-1 of vasoconstrictor response in stroke-prone spontaneously hypertensive rats. European journal of pharmacology, 2001, Mar-09, Volume: 415, Issue:1 Topics: Animals; Azepines; Dose-Response Relationship, Drug; Drug Synergism; Endothelin Receptor Antagonists; Endothelin-1; Hypertension; Indoles; Mesenteric Arteries; Norepinephrine; Oligopeptides; Piperidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Endothelin A; Receptor, Endothelin B; Species Specificity; Vasoconstriction; Vasoconstrictor Agents	2001
Endothelin is a potent inhibitor of matrix metalloproteinase-2 secretion and activation in rat mesangial cells. American journal of physiology. Renal physiology, 2001, Volume: 280, Issue:4 Topics: Animals; Antibodies, Monoclonal; Azepines; Cytochalasin D; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-2; Endothelin-3; Endothelins; Enzyme Activation; Gene Expression Regulation, Enzymologic; Glomerular Mesangium; Indoles; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Neutralization Tests; Nucleic Acid Synthesis Inhibitors; Rats; Rats, Wistar; Receptor, Endothelin A; Tissue Inhibitor of Metalloproteinase-2	2001
Endothelin-1 plays a major role in portal hypertension of biliary cirrhotic rats through endothelin receptor subtype B together with subtype A in vivo. Journal of hepatology, 2001, Volume: 34, Issue:6 Topics: Animals; Azepines; Blood Pressure; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Gene Expression; Hemodynamics; Hypertension, Portal; Indoles; Liver; Liver Cirrhosis, Biliary; Oligopeptides; Piperidines; Protein Precursors; Radioimmunoassay; Rats; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Reverse Transcriptase Polymerase Chain Reaction; RNA	2001
Evidence that ET-1, but not ET-3 and S6b, ET(A)-receptor mediated contractions in isolated rat mesenteric arteries are modulated by co-activation of ET(B) receptors. British journal of pharmacology, 2001, Volume: 133, Issue:6 Topics: Adenylyl Cyclases; Animals; Azepines; Biphenyl Compounds; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-3; In Vitro Techniques; Indoles; Male; Mesenteric Arteries; Rats; Rats, Inbred WKY; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Vasoconstriction; Viper Venoms	2001
Role of endothelin-1 receptors in healthy anaesthetized rabbits. Clinical and experimental pharmacology & physiology, 2001, Volume: 28, Issue:8 Topics: Anesthesia; Animals; Azepines; Drug Interactions; Endothelin Receptor Antagonists; Endothelin-1; Heart Rate; Indoles; Rabbits; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Vasomotor System	2001
Chelerythrine and genistein inhibit the endothelin-1-induced increase in myofilament Ca(2+) sensitivity in rabbit ventricular myocytes. European journal of pharmacology, 2001, Jul-20, Volume: 424, Issue:2 Topics: Actin Cytoskeleton; Alkaloids; Animals; Azepines; Benzophenanthridines; Calcium; Cell Size; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Genistein; Heart Ventricles; Indoles; Male; Phenanthridines; Protein Kinase C; Protein-Tyrosine Kinases; Rabbits; Receptor, Endothelin A; Spectrometry, Fluorescence	2001
Amelioration of post-ischaemic renal injury by contralateral uninephrectomy: a role of endothelin-1. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2001, Volume: 16, Issue:8 Topics: Acute Kidney Injury; Animals; Antibodies, Monoclonal; Azepines; Endothelin-1; Endothelins; Hemodynamics; Indoles; Inulin; Ischemia; Kidney; Male; Nephrectomy; Rats; Rats, Sprague-Dawley; Renal Circulation; Reperfusion Injury	2001
In depth pharmacological characterization of endothelin B receptors in the rat middle cerebral artery. Neuroscience letters, 2001, Nov-13, Volume: 314, Issue:1-2 Topics: Animals; Azepines; Blood Pressure; Charybdotoxin; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Indoles; Male; Middle Cerebral Artery; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; Receptor, Endothelin B; Receptors, Endothelin; Transducers, Pressure; Vasoconstriction; Vasoconstrictor Agents; Viper Venoms	2001
Effects of endothelin receptor A antagonist FR139317 on rats with congestive heart failure. Acta pharmacologica Sinica, 2001, Volume: 22, Issue:10 Topics: Animals; Azepines; Endothelin Receptor Antagonists; Endothelin-1; Heart Failure; Hemodynamics; Indoles; Male; Rats; Rats, Wistar; Receptor, Endothelin A; Survival Rate	2001
Use of A-192621 and IRL-2500 to unmask the mesenteric and renal vasodilator role of endothelin ET(B) receptors. Journal of cardiovascular pharmacology, 2002, Volume: 39, Issue:4 Topics: Animals; Azepines; Biphenyl Compounds; Dipeptides; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Hemodynamics; Indoles; Male; Peptide Fragments; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Renal Circulation; Splanchnic Circulation; Vasoconstriction; Vasodilation	2002
Local administration of ETA (but not ETB) blockers into the PAG area of the brain decreases blood pressure of DOCA-salt rats. Naunyn-Schmiedeberg's archives of pharmacology, 2002, Volume: 366, Issue:2 Topics: Analysis of Variance; Animals; Antihypertensive Agents; Azepines; Blood Pressure; Desoxycorticosterone; Electrophoresis, Agar Gel; Endothelin Receptor Antagonists; Endothelin-1; Glyceraldehyde-3-Phosphate Dehydrogenases; Heart Rate; Hypertension; Indans; Indoles; Male; Oligopeptides; Periaqueductal Gray; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger	2002
Chronic peripheral ouabain treatment affects the brain endothelin system of rats. Journal of hypertension, 2003, Volume: 21, Issue:4 Topics: Animals; Autoradiography; Azepines; Blood Pressure; Cardiotonic Agents; Endothelin A Receptor Antagonists; Endothelin-1; Indoles; Male; Oligopeptides; Ouabain; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Renal Artery; Vascular Resistance	2003
Investigation into the potential anti-inflammatory effects of endothelin antagonists in a murine model of experimental monosodium urate peritonitis. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 310, Issue:1 Topics: Animals; Azepines; Chemokines; Endothelin Receptor Antagonists; Endothelin-1; Indoles; Interleukin-1; Mice; Neutrophils; Oligopeptides; Peritonitis; Piperidines; Platelet Activating Factor; Time Factors; Uric Acid	2004
The distinct alterations produced in cardiovascular functions by prednisolone and nitro-prednisolone (NCX-1015) in the rat highlight a causal role for endothelin-1. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 310, Issue:3 Topics: Animals; Anti-Inflammatory Agents; Azepines; Blood Pressure; Body Weight; Cardiovascular System; Endothelin Receptor Antagonists; Endothelin-1; Heart Rate; Indoles; Kidney; Plasma; Prednisolone; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Vascular Resistance	2004
Differential inhibition by TAK-044 of the inotropic effects of endothelin-1 and endothelin-3. European journal of pharmacology, 2004, May-25, Volume: 492, Issue:2-3 Topics: Animals; Azepines; Dose-Response Relationship, Drug; Drug Interactions; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Endothelin-3; In Vitro Techniques; Indoles; Male; Myocardial Contraction; Myocardium; Oligopeptides; Papillary Muscles; Peptides, Cyclic; Piperidines; Rabbits; Radioligand Assay; Receptor, Endothelin A; Receptor, Endothelin B	2004
Analysis of ET-A and ET-B receptors using an isolated perfused rat lung preparation. Acta physiologica Scandinavica, 2004, Volume: 181, Issue:2 Topics: Animals; Antihypertensive Agents; Azepines; Bosentan; Bronchi; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Indoles; Lung; Male; Oligopeptides; Organ Culture Techniques; Perfusion; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Sulfonamides; Vasoconstrictor Agents; Viper Venoms	2004
Receptor subtypes mediating the inotropic effects and Ca(2+) signaling induced by endothelin-1 through crosstalk with norepinephrine in canine ventricular myocardium. Journal of pharmacological sciences, 2005, Volume: 97, Issue:3 Topics: Animals; Azepines; Calcium Signaling; Dogs; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Female; Heart Ventricles; Indoles; Kinetics; Male; Myocardial Contraction; Myocytes, Cardiac; Norepinephrine; Oligopeptides; Peptides, Cyclic; Piperidines; Receptor Cross-Talk; Receptors, Endothelin	2005
Enhanced expression of contractile endothelin ET(B) receptors in rat coronary artery after organ culture. European journal of pharmacology, 2008, Mar-17, Volume: 582, Issue:1-3 Topics: Animals; Azepines; Coronary Vessels; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin-1; Immunohistochemistry; Indoles; Male; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Receptor, Endothelin B; RNA, Messenger; Vasoconstriction; Vasoconstrictor Agents; Viper Venoms	2008
Endothelin and gelatinases in renal changes following blockade of nitric oxide synthase in hypertensive rats. The Chinese journal of physiology, 2008, Jun-30, Volume: 51, Issue:3 Topics: Animals; Azepines; Blood Urea Nitrogen; Collagen; Creatinine; Cyclic GMP; Disease Models, Animal; Endothelin-1; Enzyme Inhibitors; Gelatinases; Glomerular Filtration Rate; Hypertension; Indoles; Kidney; Matrix Metalloproteinases; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Tissue Inhibitor of Metalloproteinase-2	2008
Positron emission tomography of [18F]-big endothelin-1 reveals renal excretion but tissue-specific conversion to [18F]-endothelin-1 in lung and liver. British journal of pharmacology, 2010, Volume: 159, Issue:4 Topics: Animals; Aspartic Acid Endopeptidases; Autoradiography; Azepines; Endothelin A Receptor Antagonists; Endothelin-1; Endothelin-Converting Enzymes; Enzyme Activation; Fluorine Radioisotopes; Glycopeptides; Half-Life; Indoles; Infusions, Intravenous; Kidney; Lung; Male; Metalloendopeptidases; Molecular Imaging; Molecular Probe Techniques; Positron-Emission Tomography; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Tissue Distribution; Whole Body Imaging	2010
Endothelin-mediated in vivo pressor responses following TRPV1 activation. American journal of physiology. Heart and circulatory physiology, 2011, Volume: 301, Issue:3 Topics: Adrenergic alpha-Agonists; Analysis of Variance; Animals; Azepines; Biphenyl Compounds; Blood Pressure; Capsaicin; Cells, Cultured; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Dipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Femoral Artery; Indoles; Infusions, Intravenous; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenylephrine; Receptor, Endothelin A; Receptor, Endothelin B; TRPV Cation Channels; Vasoconstriction; Vasoconstrictor Agents	2011