fr 139317 has been researched along with bq 123 in 26 studies
| Studies (fr 139317) | Trials (fr 139317) | Recent Studies (post-2010) (fr 139317) | Studies (bq 123) | Trials (bq 123) | Recent Studies (post-2010) (bq 123) |
|---|---|---|---|---|---|
| 219 | 0 | 8 | 1391 | 63 | 152 |
| 219 | 0 | 8 | 1391 | 63 | 152 |
| 219 | 0 | 8 | 1391 | 63 | 152 |
| 219 | 0 | 8 | 1391 | 63 | 152 |
| 219 | 0 | 8 | 1391 | 63 | 152 |
| 219 | 0 | 8 | 1391 | 63 | 152 |
| 219 | 0 | 8 | 1391 | 63 | 152 |
| 219 | 0 | 8 | 1391 | 63 | 152 |
| 219 | 0 | 8 | 1391 | 63 | 152 |
| 219 | 0 | 8 | 1391 | 63 | 152 |
| 219 | 0 | 8 | 1391 | 63 | 152 |
| 219 | 0 | 8 | 1391 | 63 | 152 |
| 219 | 0 | 8 | 1391 | 63 | 152 |
| 219 | 0 | 8 | 1391 | 63 | 152 |
| 219 | 0 | 8 | 1391 | 63 | 152 |
| 219 | 0 | 8 | 1391 | 63 | 152 |
| 219 | 0 | 8 | 1391 | 63 | 152 |
| 219 | 0 | 8 | 1391 | 63 | 152 |
| 219 | 0 | 8 | 1391 | 63 | 152 |
| 219 | 0 | 8 | 1391 | 63 | 152 |
| 219 | 0 | 8 | 1391 | 63 | 152 |
| 219 | 0 | 8 | 1391 | 63 | 152 |
| 219 | 0 | 8 | 1391 | 63 | 152 |
| 219 | 0 | 8 | 1391 | 63 | 152 |
| 219 | 0 | 8 | 1391 | 63 | 152 |
| 219 | 0 | 8 | 1391 | 63 | 152 |
| Protein | Taxonomy | fr 139317 (IC50) | bq 123 (IC50) |
|---|---|---|---|
| Endothelin receptor type B | Homo sapiens (human) | 1 | |
| Endothelin-1 receptor | Homo sapiens (human) | 0.017 | |
| Endothelin-1 receptor | Rattus norvegicus (Norway rat) | 0.014 | |
| Endothelin-1 receptor | Sus scrofa (pig) | 22 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 22 (84.62) | 18.2507 |
| 2000's | 4 (15.38) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Davenport, AP; Maguire, JJ | 1 |
| Corder, R; Cristol, JP; Thiemermann, C; Vane, JR; Warner, TD; Wellings, RP | 2 |
| Halaka, NN; Lodge, NJ | 1 |
| Godfraind, T | 1 |
| Fukami, T; Ihara, M; Ishikawa, K; Ohwaki, K; Ozaki, S; Towers, P; Yamanaka, R; Yano, M | 1 |
| Aghai, Z; Bax, WA; Saxena, PR; van Tricht, CL; Wassenaar, C | 1 |
| Bacon, CR; Cameron, IT; Davenport, AP; Morrison, JJ; O'Reilly, G | 1 |
| Berryman, K; Davenport, AP; Doherty, AM; Fitzgerald, F; Kuc, RE; Maguire, JJ | 1 |
| Battistini, B; Fournier, A; Vane, JR; Warner, TD | 1 |
| Abboa-Offei, B; McMullen, D; Moreland, S; Seymour, A | 1 |
| Lüscher, TF; Oemar, BS; Seo, B; Siebenmann, R; von Segesser, L | 1 |
| Cosentino, F; Katusić, ZS | 1 |
| Bruttel, K; Jost, B; Randriantsoa, A; Schoeffter, P | 1 |
| Hori, M; Karaki, H; Okada, T; Sudjarwo, SA; Takai, M; Urade, Y | 1 |
| Chiou, WJ; Dixon, DB; Opgenorth, TJ; Wu-Wong, JR | 1 |
| D'Orléans-Juste, P; Henriques, MG; Rae, GA; Sampaio, AL | 1 |
| Breuiller-Fouché, M; Ferré, F; Fournier, T; Germain, G; Héluy, V | 1 |
| Donoso, MV; Edvinsson, L; Faundez, H; Fournier, A; Huidobro-Toro, JP; Rosa, G | 1 |
| Kamikawa, Y; Uchida, K; Yuzuki, R | 1 |
| Desmarets, J; Frelin, C | 1 |
| Henry, PJ; King, SH | 1 |
| Gebke, E; Gerstberger, R; Müller, AR; Pehl, U | 1 |
| Abe, Y; Isaka, M; Kitazawa, T; Takaoka, K; Taneike, T; Yamada, Y | 1 |
| Fukushima, C; Hosino, T; Kikkawa, K; Morimoto, H; Yamada, K; Yamauchi, R; Yasuda, K | 1 |
| Goto, K | 1 |
2 review(s) available for fr 139317 and bq 123
| Article | Year |
|---|---|
Does endothelin-1 play a role in the pathogenesis of cerebral vasospasm?
Topics: Animals; Azepines; Endothelin Receptor Antagonists; Endothelins; Humans; Indoles; Ischemic Attack, Transient; Oligopeptides; Peptides, Cyclic; Subarachnoid Hemorrhage | 1994 |
[Discovery of endothelin and its significance].
Topics: Amino Acid Sequence; Animals; Azepines; Cardiovascular Diseases; Drug Design; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Humans; Indans; Indoles; Molecular Sequence Data; Peptides, Cyclic; Pyrimidines; Receptors, Endothelin; Sulfonamides; Vasoconstriction | 2004 |
24 other study(ies) available for fr 139317 and bq 123
| Article | Year |
|---|---|
ETA receptor-mediated constrictor responses to endothelin peptides in human blood vessels in vitro.
Topics: Adolescent; Adult; Blood Vessels; Endothelins; Endothelium, Vascular; Female; Humans; In Vitro Techniques; Male; Middle Aged; Peptides; Receptors, Endothelin; Signal Transduction; Vasoconstriction; Vasoconstrictor Agents; Viper Venoms | 1995 |
Vasoconstriction in the rat kidney induced by endothelin-1 is blocked by PD 145065.
Topics: Amino Acid Sequence; Animals; Azepines; Blood Pressure; Endothelin Receptor Antagonists; Endothelins; Hemodynamics; In Vitro Techniques; Indoles; Molecular Sequence Data; Oligopeptides; Peptides, Cyclic; Rats; Renal Circulation; Vasoconstriction | 1993 |
Endothelin receptor subtype(s) in rabbit jugular vein smooth muscle.
Topics: Animals; Azepines; Endothelin Receptor Antagonists; Endothelins; In Vitro Techniques; Indoles; Jugular Veins; Male; Muscle Contraction; Muscle, Smooth, Vascular; Peptides, Cyclic; Rabbits; Receptors, Endothelin; Viper Venoms | 1993 |
Endothelin receptors in human coronary arteries.
Topics: Animals; Azepines; Coronary Vessels; Endothelin Receptor Antagonists; Endothelins; Humans; In Vitro Techniques; Indoles; Oligopeptides; Peptides, Cyclic; Receptors, Endothelin; Xenopus laevis | 1994 |
[3H]BQ-123, a highly specific and reversible radioligand for the endothelin ETA receptor subtype.
Topics: Amino Acid Sequence; Azepines; Binding, Competitive; Endothelin Receptor Antagonists; Endothelins; Humans; Indoles; Isotope Labeling; Molecular Sequence Data; Neuroblastoma; Oligopeptides; Peptides, Cyclic; Radioligand Assay; Receptor, Endothelin A; Receptors, Endothelin; Structure-Activity Relationship; Tritium; Tumor Cells, Cultured | 1995 |
Different endothelin receptors involved in endothelin-1- and sarafotoxin S6B-induced contractions of the human isolated coronary artery.
Topics: Adolescent; Adult; Azepines; Child; Child, Preschool; Coronary Vessels; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Endothelium, Vascular; Female; Glycopeptides; Humans; In Vitro Techniques; Indoles; Infant; Male; Middle Aged; Muscle Contraction; Muscle, Smooth, Vascular; Peptides, Cyclic; Protease Inhibitors; Protein Precursors; Receptors, Endothelin; Vasoconstrictor Agents; Viper Venoms | 1994 |
ETA and ETB endothelin receptors in human myometrium characterized by the subtype selective ligands BQ123, BQ3020, FR139317 and PD151242.
Topics: Azepines; Base Sequence; DNA Primers; Endothelin Receptor Antagonists; Endothelins; Female; Humans; Indoles; Ligands; Molecular Sequence Data; Myometrium; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Polymerase Chain Reaction; Receptors, Endothelin | 1995 |
Evidence from receptor antagonists of an important role for ETB receptor-mediated vasoconstrictor effects of endothelin-1 in the rat kidney.
Topics: Amino Acid Sequence; Anesthesia; Animals; Azepines; Blood Pressure; Endothelin Receptor Antagonists; Endothelins; In Vitro Techniques; Indoles; Indomethacin; Male; Molecular Sequence Data; Oligopeptides; Peptides, Cyclic; Rats; Rats, Wistar; Renal Circulation; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents; Viper Venoms | 1994 |
[125I]-PD151242: a selective radioligand for human ETA receptors.
Topics: Adult; Amino Acid Sequence; Aorta; Arteries; Azepines; Binding, Competitive; Coronary Vessels; Endothelin Receptor Antagonists; Endothelins; Humans; In Vitro Techniques; Indoles; Iodine Radioisotopes; Middle Aged; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Pulmonary Artery; Radioligand Assay; Receptors, Endothelin | 1994 |
Characterization of ETB receptors mediating contractions induced by endothelin-1 or IRL 1620 in guinea-pig isolated airways: effects of BQ-123, FR139317 or PD 145065.
Topics: Animals; Azepines; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; Guinea Pigs; In Vitro Techniques; Indoles; Male; Muscle Contraction; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Receptors, Endothelin; Respiratory Physiological Phenomena; Respiratory System | 1994 |
Evidence for a differential location of vasoconstrictor endothelin receptors in the vasculature.
Topics: Animals; Azepines; Blood Pressure; Blood Vessels; Dogs; Endothelin Receptor Antagonists; Female; In Vitro Techniques; Indoles; Isometric Contraction; Macaca fascicularis; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Peptides, Cyclic; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Species Specificity; Swine; Vasoconstrictor Agents; Viper Venoms | 1994 |
Both ETA and ETB receptors mediate contraction to endothelin-1 in human blood vessels.
Topics: Animals; Azepines; Bosentan; Coronary Vessels; Endothelin Receptor Antagonists; Endothelins; Endothelium, Vascular; Female; Humans; Indoles; Male; Mammary Arteries; Middle Aged; Muscle, Smooth, Vascular; Peptides, Cyclic; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Sulfonamides; Swine; Viper Venoms | 1994 |
Comparative effects of the two endothelin ETA receptor antagonists, BQ-123 and FR139317, on endothelin-1-induced contraction in guinea-pig iliac artery.
Topics: Animals; Aorta, Abdominal; Azepines; Endothelin Receptor Antagonists; Endothelins; Femoral Artery; Guinea Pigs; Iliac Artery; In Vitro Techniques; Indoles; Male; Peptides, Cyclic; Receptor, Endothelin A; Vasoconstriction | 1993 |
A novel subtype of endothelin B receptor mediating contraction in swine pulmonary vein.
Topics: Animals; Azepines; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; Indoles; Peptide Fragments; Peptides, Cyclic; Pulmonary Veins; Rabbits; Receptors, Endothelin; Saphenous Vein; Swine; Vasoconstriction; Vasoconstrictor Agents; Viper Venoms | 1993 |
Dissociation characteristics of endothelin ETA receptor agonists and antagonists.
Topics: Amino Acid Sequence; Animals; Azepines; Endothelin Receptor Antagonists; Endothelins; Indoles; Molecular Sequence Data; Peptides, Cyclic; Pituitary Neoplasms; Pyrimidines; Rats; Receptor, Endothelin A; Receptors, Endothelin; Sulfonamides; Tumor Cells, Cultured | 1995 |
ETA receptor antagonists inhibit allergic inflammation in the mouse.
Topics: Animals; Azepines; Edema; Endothelin Receptor Antagonists; Endothelins; Indoles; Male; Mice; Ovalbumin; Peptides, Cyclic; Receptor, Endothelin A | 1995 |
Endothelin ETA receptors mediate human uterine smooth muscle contraction.
Topics: Adult; Amino Acid Sequence; Azepines; Endothelins; Female; Humans; In Vitro Techniques; Indoles; Middle Aged; Molecular Sequence Data; Peptides, Cyclic; Receptors, Endothelin; Uterine Contraction | 1995 |
Pharmacological characterization of the ETA receptor in the vascular smooth muscle comparing its analogous distribution in the rat mesenteric artery and in the arterial mesenteric bed.
Topics: Animals; Azepines; Endothelin Receptor Antagonists; Indoles; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Receptors, Endothelin | 1996 |
Pharmacological characterization of endothelin-induced contraction in the guinea-pig oesophageal muscularis mucosae.
Topics: Animals; Azepines; Calcium Channels; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-2; Endothelin-3; Endothelins; Esophagus; Guinea Pigs; Humans; Imidazoles; Indoles; Male; Muscle Contraction; Muscle, Smooth; Peptides, Cyclic; Receptors, Endothelin; Viper Venoms | 1998 |
High affinity interaction of endothelin-3 with recombinant ETA receptors.
Topics: Animals; Azepines; Binding, Competitive; Cattle; Cell Line; Cell Membrane; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-3; Endothelins; Indoles; Kinetics; Ligands; Peptide Fragments; Peptides, Cyclic; Protein Isoforms; Rats; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Recombinant Proteins; Transfection; Tyrosine; Viper Venoms | 1999 |
Typical endothelin ETA receptors mediate atypical endothelin-1-induced contractions in sheep isolated tracheal smooth muscle.
Topics: Animals; Azepines; Binding, Competitive; Endothelin Receptor Antagonists; Endothelin-1; In Vitro Techniques; Indoles; Kinetics; Muscle Contraction; Muscle, Smooth; Peptides, Cyclic; Radioligand Assay; Receptor, Endothelin A; Receptors, Endothelin; Sheep; Trachea; Vasoconstrictor Agents; Viper Venoms | 1999 |
Astrocytes in sensory circumventricular organs of the rat brain express functional binding sites for endothelin.
Topics: Animals; Astrocytes; Autoradiography; Azepines; Cell Membrane; Cells, Cultured; Cerebral Ventricles; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-3; Indoles; Iodine Radioisotopes; Kinetics; Male; Neuroglia; Neurons; Peptides, Cyclic; Radioligand Assay; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin | 2000 |
Characterization of functional endothelin receptors in the porcine myometrium.
Topics: Animals; Azepines; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-3; Endothelins; Female; In Vitro Techniques; Indoles; Iodine Radioisotopes; Myometrium; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Piperidines; Radioligand Assay; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Reverse Transcriptase Polymerase Chain Reaction; Swine; Uterine Contraction; Vasoconstrictor Agents; Viper Venoms | 2000 |
Design, syntheses, and structure-activity relationships of indan derivatives as endothelin antagonists; new lead generation of non-peptidic antagonist from peptidic leads.
Topics: Antihypertensive Agents; Azepines; Drug Design; Endothelins; Indans; Indoles; Inhibitory Concentration 50; Models, Molecular; Molecular Conformation; Peptides, Cyclic; Protein Binding; Receptor, Endothelin A; Receptors, Endothelin; Structure-Activity Relationship | 2001 |