Compounds > fr 139317

Page last updated: 2024-09-02

fr 139317 and bosentan anhydrous

fr 139317 has been researched along with bosentan anhydrous in 18 studies

Study Comparison

Studies (fr 139317)	Trials (fr 139317)	Recent Studies (post-2010) (fr 139317)	Studies (bosentan anhydrous)	Trials (bosentan anhydrous)	Recent Studies (post-2010) (bosentan anhydrous)
219	0	8	1836	215	630
219	0	8	1836	215	630
219	0	8	1836	215	630
219	0	8	1836	215	630
219	0	8	1836	215	630
219	0	8	1836	215	630
219	0	8	1836	215	630
219	0	8	1836	215	630
219	0	8	1836	215	630
219	0	8	1836	215	630
219	0	8	1836	215	630
219	0	8	1836	215	630
219	0	8	1836	215	630
219	0	8	1836	215	630
219	0	8	1836	215	630
219	0	8	1836	215	630
219	0	8	1836	215	630
219	0	8	1836	215	630

Protein Interaction Comparison

Protein	Taxonomy	fr 139317 (IC50)	bosentan anhydrous (IC50)
Multidrug resistance-associated protein 4	Homo sapiens (human)		22
Bile salt export pump	Homo sapiens (human)		27.48
Endothelin receptor type B	Rattus norvegicus (Norway rat)		0.095
Endothelin receptor type B	Homo sapiens (human)		0.3044
Endothelin-1 receptor	Homo sapiens (human)		0.2317
Endothelin-1 receptor	Rattus norvegicus (Norway rat)		0.0047
Sodium/bile acid cotransporter	Homo sapiens (human)		30000
Endothelin-1 receptor	Sus scrofa (pig)		0.0075

Research

Studies (18)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	16 (88.89)	18.2507
2000's	2 (11.11)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Filep, JG; Földes-Filep, E; Fournier, A	1
Lüscher, TF; Seo, B	1
Lüscher, TF; Moreau, P; Takase, H	1
Clozel, M; Filep, JG; Földes-Filep, E; Fournier, A	1
Lüscher, TF; Tschudi, MR	1
Lüscher, TF; Oemar, BS; Seo, B; Siebenmann, R; von Segesser, L	1
Berrino, L; D'Amico, M; Maione, S; Rossi, F	1
Bakken, IJ; Edvinsson, L; Elsås, T; Sjaavaag, I; Vincent, MB; White, LR	1
Adner, M; Edvinsson, L; Goadsby, PJ	1
Chiou, WJ; Dixon, DB; Opgenorth, TJ; Wu-Wong, JR	1
Filep, JG	2
D'Amico, M; Di Filippo, C; Rossi, F	1
Best, PJ; Cannan, CR; Hasdai, D; Holmes, DR; Lerman, A; Mathew, V; Schwartz, RS	1
Aasly, J; Adner, M; Cappelen, J; Edvinsson, L; Juul, R; Leseth, KH; White, LR	1
Bellissant, E; Durand-Castel, X; Goineau, S; Guillo, P; Pape, D	1
D'Agostino, B; Di Pierro, P; Falciani, M; Filippelli, A; Gallelli, L; Rossi, F	1
Edvinsson, L; Granström, B; Hultkvist-Bengtsson, U; Nilsson, E	1

Other Studies

18 other study(ies) available for fr 139317 and bosentan anhydrous

Article	Year
Acute pro-inflammatory actions of endothelin-1 in the guinea-pig lung: involvement of ETA and ETB receptors. British journal of pharmacology, 1995, Volume: 115, Issue:2 Topics: Animals; Azepines; Blood Pressure; Bosentan; Bronchopulmonary Sequestration; Capillary Permeability; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; Guinea Pigs; In Vitro Techniques; Indoles; Injections, Intravenous; Lung; Macrophages, Alveolar; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutropenia; Neutrophils; Peptide Fragments; Plasma Volume; Platelet Activating Factor; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate	1995
ETA and ETB receptors mediate contraction to endothelin-1 in renal artery of aging SHR. Effects of FR139317 and bosentan. Hypertension (Dallas, Tex. : 1979), 1995, Volume: 25, Issue:4 Pt 1 Topics: Aging; Animals; Azepines; Bosentan; Drug Interactions; Endothelin Receptor Antagonists; Endothelins; Indoles; Male; Muscle, Smooth, Vascular; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Renal Artery; Species Specificity; Sulfonamides; Vasoconstriction; Vasoconstrictor Agents; Viper Venoms	1995
Endothelin receptor subtypes in small arteries. Studies with FR139317 and bosentan. Hypertension (Dallas, Tex. : 1979), 1995, Volume: 25, Issue:4 Pt 2 Topics: Animals; Arteries; Azepines; Bosentan; Endothelin Receptor Antagonists; Endothelins; Indoles; Male; Rats; Rats, Inbred WKY; Receptors, Endothelin; Splanchnic Circulation; Sulfonamides; Vasoconstriction; Vasoconstrictor Agents; Viper Venoms	1995
Characterization of receptors mediating vascular responses to endothelin-1 in the conscious rat. British journal of pharmacology, 1994, Volume: 113, Issue:3 Topics: Animals; Azepines; Blood Pressure; Bosentan; Capillary Permeability; Endothelins; Evans Blue; Indoles; Male; Peptide Fragments; Rats; Rats, Wistar; Receptors, Endothelin; Serum Albumin; Sulfonamides	1994
Characterization of contractile endothelin and angiotensin receptors in human resistance arteries: evidence for two endothelin and one angiotensin receptor. Biochemical and biophysical research communications, 1994, Oct-28, Volume: 204, Issue:2 Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Azepines; Benzazepines; Bosentan; Endothelin Receptor Antagonists; Endothelins; Humans; In Vitro Techniques; Indoles; Mammary Arteries; Muscle Contraction; Plasmids; Receptors, Angiotensin; Receptors, Endothelin; Sulfonamides; Tetrazoles; Valine; Valsartan; Vasoconstrictor Agents; Viper Venoms	1994
Both ETA and ETB receptors mediate contraction to endothelin-1 in human blood vessels. Circulation, 1994, Volume: 89, Issue:3 Topics: Animals; Azepines; Bosentan; Coronary Vessels; Endothelin Receptor Antagonists; Endothelins; Endothelium, Vascular; Female; Humans; Indoles; Male; Mammary Arteries; Middle Aged; Muscle, Smooth, Vascular; Peptides, Cyclic; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Sulfonamides; Swine; Viper Venoms	1994
Selective and non-selective ET antagonists reveal an ETB receptors mediated ET-1-induced behavioural effect in conscious rats. Life sciences, 1996, Volume: 58, Issue:10 Topics: Animals; Azepines; Behavior, Animal; Bosentan; Consciousness; Endothelin Receptor Antagonists; Endothelins; Indoles; Male; Oligopeptides; Periaqueductal Gray; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Sulfonamides	1996
Vasoactivity mediated by endothelin ETA and ETB receptors in isolated porcine ophthalmic artery. Acta physiologica Scandinavica, 1996, Volume: 157, Issue:2 Topics: Animals; Azepines; Bosentan; Dinoprost; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-3; In Vitro Techniques; Indoles; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Ophthalmic Artery; Receptors, Endothelin; Sulfonamides; Swine; Vasoconstrictor Agents; Viper Venoms	1996
Characterization of endothelin receptors in the cerebral vasculature and their lack of effect on spreading depression. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1996, Volume: 16, Issue:4 Topics: Animals; Azepines; Blood Vessels; Bosentan; Cats; Cerebrovascular Circulation; Cortical Spreading Depression; Indoles; Laser-Doppler Flowmetry; Receptors, Endothelin; Sulfonamides	1996
Endothelin receptor antagonists: effect of serum albumin on potency and comparison of pharmacological characteristics. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 281, Issue:2 Topics: Acetamides; Animals; Atrasentan; Azepines; Binding, Competitive; Bosentan; Cells, Cultured; CHO Cells; Cricetinae; Dioxoles; Endothelin Receptor Antagonists; Endothelin-1; Hydrolysis; Indoles; Phosphatidylinositols; Pyrrolidines; Rats; Serum Albumin, Bovine; Sulfonamides; Swine	1997
Endogenous endothelin modulates blood pressure, plasma volume, and albumin escape after systemic nitric oxide blockade. Hypertension (Dallas, Tex. : 1979), 1997, Volume: 30, Issue:1 Pt 1 Topics: Analysis of Variance; Animals; Antihypertensive Agents; Azepines; Blood Pressure; Bosentan; Data Interpretation, Statistical; Endothelin Receptor Antagonists; Endothelin-1; Hydralazine; Indoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Plasma Volume; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Serum Albumin; Sulfonamides; Time Factors; Vasodilator Agents	1997
Selective and non-selective ET antagonists reveal an ET(A)/ET(B) receptor mediated ET-1-induced antinociceptive effect in PAG area of mice. Life sciences, 1997, Volume: 61, Issue:25 Topics: Analgesics; Animals; Azepines; Bosentan; Endothelin Receptor Antagonists; Endothelin-1; Indoles; Male; Mice; Periaqueductal Gray; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Sulfonamides	1997
Acute endothelin-receptor inhibition does not attenuate acetylcholine-induced coronary vasoconstriction in experimental hypercholesterolemia. Arteriosclerosis, thrombosis, and vascular biology, 1998, Volume: 18, Issue:1 Topics: Acetylcholine; Animals; Antihypertensive Agents; Azepines; Blood Pressure; Bosentan; Cholesterol; Coronary Vessels; Diet, Atherogenic; Endothelin Receptor Antagonists; Endothelin-1; Hemodynamics; Hypercholesterolemia; Indoles; Receptors, Endothelin; Sulfonamides; Swine; Vasoconstriction; Vasoconstrictor Agents; Viper Venoms	1998
Increased endothelin ETB contractile activity in cultured segments of human temporal artery. Acta physiologica Scandinavica, 1998, Volume: 164, Issue:1 Topics: Azepines; Bosentan; Dose-Response Relationship, Drug; Endothelin-1; Endothelin-3; Humans; Indoles; Muscle, Smooth, Vascular; Oligopeptides; Organ Culture Techniques; Piperidines; Receptor, Endothelin B; Receptors, Endothelin; Sulfonamides; Temporal Arteries; Vasoconstriction; Vasoconstrictor Agents; Viper Venoms	1998
Endothelin, but not angiotensin II, contributes to the hypoxic contractile response of large isolated pulmonary arteries in the rat. Fundamental & clinical pharmacology, 1999, Volume: 13, Issue:4 Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Azepines; Bosentan; Calcium; Calcium Channel Blockers; Endothelin Receptor Antagonists; Endothelins; Endothelium, Vascular; Extracellular Space; Glycopeptides; Hypoxia; In Vitro Techniques; Indoles; Lisinopril; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Pulmonary Artery; Rats; Rats, Wistar; Sulfonamides	1999
Endothelin-1 induced bronchial hyperresponsiveness in the rabbit: an ET(A) receptor-mediated phenomenon. Naunyn-Schmiedeberg's archives of pharmacology, 1999, Volume: 360, Issue:6 Topics: Administration, Inhalation; Airway Resistance; Animals; Antihypertensive Agents; Azepines; Bosentan; Bronchi; Bronchoconstriction; Endothelin Receptor Antagonists; Endothelin-1; Female; Histamine; Indoles; Male; Muscle, Smooth; Rabbits; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Respiratory Hypersensitivity; Sulfonamides; Vasoconstrictor Agents; Viper Venoms	1999
Role for endogenous endothelin in the regulation of plasma volume and albumin escape during endotoxin shock in conscious rats. British journal of pharmacology, 2000, Volume: 129, Issue:5 Topics: Animals; Azepines; Bacterial Toxins; Blood Pressure; Bosentan; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Enterotoxins; Erythrocyte Volume; Escherichia coli Proteins; Indoles; Lipopolysaccharides; Male; Plasma Volume; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Regional Blood Flow; Serum Albumin; Serum Albumin, Radio-Iodinated; Shock, Septic; Sulfonamides	2000
Analysis of ET-A and ET-B receptors using an isolated perfused rat lung preparation. Acta physiologica Scandinavica, 2004, Volume: 181, Issue:2 Topics: Animals; Antihypertensive Agents; Azepines; Bosentan; Bronchi; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Indoles; Lung; Male; Oligopeptides; Organ Culture Techniques; Perfusion; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Sulfonamides; Vasoconstrictor Agents; Viper Venoms	2004