fr 121196 has been researched along with scopolamine hydrobromide in 5 studies
| Studies (fr 121196) | Trials (fr 121196) | Recent Studies (post-2010) (fr 121196) | Studies (scopolamine hydrobromide) | Trials (scopolamine hydrobromide) | Recent Studies (post-2010) (scopolamine hydrobromide) |
|---|---|---|---|---|---|
| 6 | 0 | 0 | 7,548 | 563 | 1,401 |
| Protein | Taxonomy | fr 121196 (IC50) | scopolamine hydrobromide (IC50) |
|---|---|---|---|
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | 0.003 | |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | 0.006 | |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | 0.006 | |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | 0.006 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.0006 | |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | 0.006 | |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | 0.006 | |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 0.0026 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maeda, N; Matsuoka, N; Ohkubo, Y; Yamaguchi, I; Yamazaki, M | 1 |
| Kuratani, K; Maeda, N; Matsuoka, N; Ohkubo, Y; Yamaguchi, I; Yamazaki, M | 1 |
| Matsuoka, N; Satoh, M; Yamaguchi, I | 1 |
| Maeda, N; Matsuoka, N; Satoh, M; Yamaguchi, I | 1 |
| Arakawa, H; Maeda, N; Matsuoka, N; Ohkubo, Y; Yamaguchi, I; Yamazaki, M | 1 |
5 other study(ies) available for fr 121196 and scopolamine hydrobromide
| Article | Year |
|---|---|
Effect of FR121196, a novel cognitive enhancer, on the memory impairment of rats in passive avoidance and radial arm maze tasks.
Topics: Aging; Animals; Avoidance Learning; Brain; Choline O-Acetyltransferase; Cognition Disorders; Dementia; Discrimination Learning; Disease Models, Animal; Male; Memory Disorders; Methamphetamine; Motor Activity; Physostigmine; Piperazines; Rats; Rats, Inbred F344; Rats, Wistar; Scopolamine; Sulfonamides | 1992 |
FR121196, a potential antidementia drug, ameliorates the impaired memory of rat in the Morris water maze.
Topics: Age Factors; Animals; Brain; Cholinergic Fibers; Ibotenic Acid; Male; Maze Learning; Memory; Methamphetamine; Physostigmine; Piperazines; Rats; Rats, Inbred F344; Scopolamine; Space Perception; Sulfonamides | 1995 |
Role of somatostatin in the augmentation of hippocampal long-term potentiation by FR121196, a putative cognitive enhancer.
Topics: Animals; Catecholamines; Cognition; Cysteamine; Electrophysiology; Guinea Pigs; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Methamphetamine; Nerve Fibers; Neural Pathways; Physostigmine; Piperazines; Scopolamine; Somatostatin; Sulfonamides | 1993 |
Possible involvement of brain somatostatin in the memory formation of rats and the cognitive enhancing action of FR121196 in passive avoidance task.
Topics: Acetylcholine; Animals; Avoidance Learning; Brain; Cognition; Cysteamine; Injections, Intraventricular; Male; Memory; Physostigmine; Piperazines; Rats; Rats, Inbred F344; Rats, Wistar; Retention, Psychology; Scopolamine; Somatostatin; Sulfonamides | 1994 |
A screening concept based on a hypothesis led to the development of a putative cognitive enhancer that stimulates penile erection.
Topics: Animals; Anorexia; Avoidance Learning; Behavior, Animal; Cognition; Cysteamine; Drug Evaluation, Preclinical; Drug Interactions; Male; Memory Disorders; Penile Erection; Piperazines; Rats; Rats, Inbred F344; Rats, Wistar; Rats, Zucker; Scopolamine; Stimulation, Chemical; Sulfonamides; Sulpiride; Weight Gain | 1994 |