fr 121196 has been researched along with physostigmine in 4 studies
| Studies (fr 121196) | Trials (fr 121196) | Recent Studies (post-2010) (fr 121196) | Studies (physostigmine) | Trials (physostigmine) | Recent Studies (post-2010) (physostigmine) |
|---|---|---|---|---|---|
| 6 | 0 | 0 | 6,230 | 252 | 331 |
| Protein | Taxonomy | fr 121196 (IC50) | physostigmine (IC50) |
|---|---|---|---|
| Acetylcholinesterase | Electrophorus electricus (electric eel) | 0.1666 | |
| Acetylcholinesterase | Tetronarce californica (Pacific electric ray) | 0.3023 | |
| Cholinesterase | Homo sapiens (human) | 0.3055 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 0.2 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.857 | |
| Acetylcholinesterase | Mus musculus (house mouse) | 0.0269 | |
| Acetylcholinesterase | Homo sapiens (human) | 0.0853 | |
| Acetylcholinesterase | Bos taurus (cattle) | 0.7197 | |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | 0.857 | |
| Delta-type opioid receptor | Mus musculus (house mouse) | 1.1821 | |
| Acetylcholinesterase | Gallus gallus (chicken) | 0.02 | |
| Acetylcholinesterase | Rattus norvegicus (Norway rat) | 0.0416 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.857 | |
| Cholinesterase | Equus caballus (horse) | 0.4081 | |
| Cholinesterase | Mus musculus (house mouse) | 0.28 | |
| Acyl-CoA:cholesterol acyltransferase | Oryctolagus cuniculus (rabbit) | 0.0189 | |
| Carboxylic ester hydrolase | Rattus norvegicus (Norway rat) | 0.018 | |
| Carboxylic ester hydrolase | Equus caballus (horse) | 1.263 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maeda, N; Matsuoka, N; Ohkubo, Y; Yamaguchi, I; Yamazaki, M | 1 |
| Kuratani, K; Maeda, N; Matsuoka, N; Ohkubo, Y; Yamaguchi, I; Yamazaki, M | 1 |
| Matsuoka, N; Satoh, M; Yamaguchi, I | 1 |
| Maeda, N; Matsuoka, N; Satoh, M; Yamaguchi, I | 1 |
4 other study(ies) available for fr 121196 and physostigmine
| Article | Year |
|---|---|
Effect of FR121196, a novel cognitive enhancer, on the memory impairment of rats in passive avoidance and radial arm maze tasks.
Topics: Aging; Animals; Avoidance Learning; Brain; Choline O-Acetyltransferase; Cognition Disorders; Dementia; Discrimination Learning; Disease Models, Animal; Male; Memory Disorders; Methamphetamine; Motor Activity; Physostigmine; Piperazines; Rats; Rats, Inbred F344; Rats, Wistar; Scopolamine; Sulfonamides | 1992 |
FR121196, a potential antidementia drug, ameliorates the impaired memory of rat in the Morris water maze.
Topics: Age Factors; Animals; Brain; Cholinergic Fibers; Ibotenic Acid; Male; Maze Learning; Memory; Methamphetamine; Physostigmine; Piperazines; Rats; Rats, Inbred F344; Scopolamine; Space Perception; Sulfonamides | 1995 |
Role of somatostatin in the augmentation of hippocampal long-term potentiation by FR121196, a putative cognitive enhancer.
Topics: Animals; Catecholamines; Cognition; Cysteamine; Electrophysiology; Guinea Pigs; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Methamphetamine; Nerve Fibers; Neural Pathways; Physostigmine; Piperazines; Scopolamine; Somatostatin; Sulfonamides | 1993 |
Possible involvement of brain somatostatin in the memory formation of rats and the cognitive enhancing action of FR121196 in passive avoidance task.
Topics: Acetylcholine; Animals; Avoidance Learning; Brain; Cognition; Cysteamine; Injections, Intraventricular; Male; Memory; Physostigmine; Piperazines; Rats; Rats, Inbred F344; Rats, Wistar; Retention, Psychology; Scopolamine; Somatostatin; Sulfonamides | 1994 |