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fr 110302 and indomethacin

fr 110302 has been researched along with indomethacin in 2 studies

*Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES. [MeSH]

Compound Research Comparison

Studies (fr 110302)	Trials (fr 110302)	Recent Studies (post-2010) (fr 110302)	Studies (indomethacin)	Trials (indomethacin)	Recent Studies (post-2010) (indomethacin)
5	0	0	29,527	1,838	3,396

Protein Interaction Comparison

Protein	Taxonomy	indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2	Macaca fascicularis (crab-eating macaque)	1000
Prostaglandin-H2 D-isomerase	Mus musculus (house mouse)	1.1
Multidrug resistance-associated protein 4	Homo sapiens (human)	5.8
Prostaglandin G/H synthase 1	Bos taurus (cattle)	0.9994
Prostaglandin G/H synthase 2	Bos taurus (cattle)	0.7764
Cytochrome c oxidase subunit 2	Homo sapiens (human)	0.34
Prostaglandin G/H synthase 1	Ovis aries (sheep)	0.5605
Neuronal acetylcholine receptor subunit alpha-4	Rattus norvegicus (Norway rat)	0.004
Interleukin-8	Homo sapiens (human)	0.05
Neuronal acetylcholine receptor subunit beta-2	Rattus norvegicus (Norway rat)	0.004
Aldo-keto reductase family 1 member B1	Homo sapiens (human)	6
Aldo-keto reductase family 1 member B1	Bos taurus (cattle)	5
Prostaglandin G/H synthase 1	Mus musculus (house mouse)	0.011
Prostaglandin G/H synthase 1	Homo sapiens (human)	0.4848
Sodium- and chloride-dependent GABA transporter 1	Rattus norvegicus (Norway rat)	0.2
Thromboxane-A synthase	Homo sapiens (human)	0.1
Indoleamine 2,3-dioxygenase 1	Mus musculus (house mouse)	0.082
Nitric oxide synthase, inducible	Mus musculus (house mouse)	4.5
Substance-P receptor	Cavia porcellus (domestic guinea pig)	5.7
Sodium- and chloride-dependent GABA transporter 2	Rattus norvegicus (Norway rat)	0.2
Sodium- and chloride-dependent GABA transporter 3	Rattus norvegicus (Norway rat)	0.2
Prostaglandin G/H synthase 2	Homo sapiens (human)	1.5128
Prostaglandin G/H synthase 2	Rattus norvegicus (Norway rat)	0.5504
Aldo-keto reductase family 1 member C3	Homo sapiens (human)	3.4486
Sodium- and chloride-dependent betaine transporter	Rattus norvegicus (Norway rat)	0.2
C-X-C chemokine receptor type 3	Homo sapiens (human)	0.05
Aldo-keto reductase family 1 member C2	Homo sapiens (human)	8.97
Prostaglandin G/H synthase 2	Ovis aries (sheep)	3.4647
Prostaglandin G/H synthase 2	Mus musculus (house mouse)	0.4233
Solute carrier family 22 member 6	Homo sapiens (human)	3
Sigma intracellular receptor 2	Rattus norvegicus (Norway rat)	0.49
Rho-associated protein kinase 2	Rattus norvegicus (Norway rat)	7.7
Prostaglandin G/H synthase 1	Rattus norvegicus (Norway rat)	0.5461
P2Y purinoceptor 12	Rattus norvegicus (Norway rat)	0.96

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Asano, M; Hamada, K; Inamura, N; Isono, T; Kohsaka, M; Nagayoshi, A; Nakahara, K; Notsu, Y; Oku, T; Ono, T	1
Hagihara, H; Mutoh, S; Nomoto, A; Ono, T; Yamaguchi, I	1

Other Studies

2 other study(ies) available for fr 110302 and indomethacin

Article	Year
A 5-lipoxygenase inhibitor, FR110302, suppresses airway hyperresponsiveness and lung eosinophilia induced by Sephadex particles in rats. Agents and actions, 1992, Volume: 36, Issue:3-4 Topics: Acetylcholine; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Chromones; Dextrans; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Indomethacin; Leukotriene B4; Lipoxygenase Inhibitors; Male; Microspheres; Naphthols; Platelet Activating Factor; Prednisolone; Pulmonary Eosinophilia; Pyridines; Quinolines; Rats; Rats, Inbred Strains; SRS-A; Thiazoles	1992
Role of inflammatory responses in initiation of atherosclerosis: effects of anti-inflammatory drugs on cuff-induced leukocyte accumulation and intimal thickening of rabbit carotid artery. Atherosclerosis, 1991, Volume: 91, Issue:1-2 Topics: Animals; Anti-Inflammatory Agents; Arteriosclerosis; Carotid Arteries; Cell Adhesion; Cell Movement; Dexamethasone; Dose-Response Relationship, Drug; Endothelium, Vascular; Indomethacin; Inflammation; Male; Microscopy, Electron, Scanning; Naphthols; Neutrophils; Quinolines; Rabbits	1991

Article

Year

A 5-lipoxygenase inhibitor, FR110302, suppresses airway hyperresponsiveness and lung eosinophilia induced by Sephadex particles in rats.

Agents and actions, 1992, Volume: 36, Issue:3-4

Topics: Acetylcholine; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Chromones; Dextrans; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Indomethacin; Leukotriene B4; Lipoxygenase Inhibitors; Male; Microspheres; Naphthols; Platelet Activating Factor; Prednisolone; Pulmonary Eosinophilia; Pyridines; Quinolines; Rats; Rats, Inbred Strains; SRS-A; Thiazoles

1992

Role of inflammatory responses in initiation of atherosclerosis: effects of anti-inflammatory drugs on cuff-induced leukocyte accumulation and intimal thickening of rabbit carotid artery.

Atherosclerosis, 1991, Volume: 91, Issue:1-2

Topics: Animals; Anti-Inflammatory Agents; Arteriosclerosis; Carotid Arteries; Cell Adhesion; Cell Movement; Dexamethasone; Dose-Response Relationship, Drug; Endothelium, Vascular; Indomethacin; Inflammation; Male; Microscopy, Electron, Scanning; Naphthols; Neutrophils; Quinolines; Rabbits

1991