fpl 64176 has been researched along with bay-k-8644 in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (40.00) | 18.2507 |
| 2000's | 12 (48.00) | 29.6817 |
| 2010's | 3 (12.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baxter, AJ; Dixon, J; Ince, F; Manners, CN; Teague, SJ | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Cai, W; Hao, Y; Hu, P; Ma, D; Pan, H; Xie, X; Yu, AD; Yu, J; Yuan, J; Zhang, L; Zhu, H | 1 |
| Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J | 1 |
| Kunze, DL; Rampe, D | 1 |
| Dage, RC; Rampe, D | 1 |
| Rampe, D; Triggle, DJ; Zheng, W | 1 |
| Cheung, CW; Gigg, M; Hartley, SA; Jones, LM; Usowicz, MM | 1 |
| Anderson, B; Dage, RC; Li, T; Rampe, D; Rapien-Pryor, V | 1 |
| Dooley, DJ; Feuerstein, TJ; Ginap, T | 1 |
| Fuhlendorff, J; Gromada, J; Madsen, P; Springborg, J; Varming, AR | 1 |
| Handrock, R; Herzig, S; Hofmann, F; Lauven, M; Müller, A | 1 |
| Drew, T; Jinnah, HA; Kim, BS; Rothstein, JD; Visser, JE; Yitta, S | 1 |
| Drew, T; Hess, EJ; Ho, T; Jinnah, HA; Rothstein, JD; Sepkuty, JP; Yitta, S | 1 |
| Fan, JS; Palade, P; Yuan, Y | 1 |
| Coyne, MD; Gwathmey, JK; Kim, CS | 1 |
| Bers, DM; Katoh, H; Schlotthauer, K | 1 |
| Altschuld, RA; Cheng, Y; Dumitrescu, C; Efimov, IR; Narayan, P | 1 |
| Bowden, SE; Cloues, RK; Marrion, NV; Shepherd, D; Tavalin, SJ | 1 |
| Bean, BP; McDonough, SI; Mori, Y | 1 |
| Chen, X; Dore, J; Liu, Y | 1 |
| Grenett, HE; Huang, J; Ku, DD; Urthaler, F; Wolkowicz, PE; Wu, HC | 1 |
| Atlas, D; Hagalili, Y; Marom, M; Sebag, A; Tzvier, L | 1 |
| Cao, X; Fang, YY; Gao, TM; Hou, FQ; Hu, HH; Li, SJ; Wang, P; Yan, HC; Zhu, XH | 1 |
| Colbran, RJ; Pasek, JG; Wang, X | 1 |
25 other study(ies) available for fpl 64176 and bay-k-8644
| Article | Year |
|---|---|
Discovery and synthesis of methyl 2,5-dimethyl-4-[2- (phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogues: the first examples of a new class of calcium channel activator.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Agonists; Guinea Pigs; Myocardial Contraction; Pyrroles; Rats; Stereoisomerism; Structure-Activity Relationship | 1993 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Small molecule regulators of autophagy identified by an image-based high-throughput screen.
Topics: Autophagy; Calcium Channel Blockers; Cell Line, Tumor; Drug Evaluation, Preclinical; Fluspirilene; Glioblastoma; Green Fluorescent Proteins; Humans; Intracellular Membranes; Loperamide; Microtubule-Associated Proteins; Mycotoxins; Peptides; Phagosomes; Phosphatidylinositol Phosphates; Pimozide; Protein Kinases; Recombinant Fusion Proteins; Sirolimus; Small Molecule Libraries; TOR Serine-Threonine Kinases; Trifluoperazine; Zinc Fingers | 2007 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection | 2009 |
Characterization of the effects of a new Ca2+ channel activator, FPL 64176, in GH3 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channels; Cells, Cultured; Electric Conductivity; In Vitro Techniques; Ion Channel Gating; Pituitary Gland, Anterior; Pyrroles; Rats | 1992 |
Functional interactions between two Ca2+ channel activators, (S)-Bay K 8644 and FPL 64176, in smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channels; Drug Interactions; In Vitro Techniques; Kinetics; Male; Membrane Potentials; Muscle, Smooth, Vascular; Pyrroles; Rats | 1992 |
Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; Isradipine; Male; Myocardium; Potassium; Pyrroles; Radioligand Assay; Rats; Vasoconstriction; Verapamil | 1991 |
Allosteric interactions at L-type calcium channels between FPL 64176 and the enantiomers of the dihydropyridine Bay K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Allosteric Regulation; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Guinea Pigs; In Vitro Techniques; Ion Channel Gating; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Potassium Chloride; Pyrroles; Stereoisomerism | 1995 |
Comparison of the in vitro and in vivo cardiovascular effects of two structurally distinct Ca++ channel activators, BAY K 8644 and FPL 64176.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Blood Pressure; Calcium Channels; Guinea Pigs; Heart; In Vitro Techniques; Male; Myocardial Contraction; Pyrroles; Rats | 1993 |
The non-dihydropyridine L-type voltage-sensitive calcium channel activator FPL 64176 enhances K(+)-evoked efflux of [3H]norepinephrine from rat neocortical slices.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Binding, Competitive; Calcium Channels; Cell Membrane; Cerebral Cortex; Dose-Response Relationship, Drug; In Vitro Techniques; Isradipine; Kinetics; Male; Norepinephrine; Potassium; Pyrroles; Rats; Rats, Sprague-Dawley; Tritium | 1993 |
Increase in [Ca2+]i and subsequent insulin release from beta TC3-cells with the L-type Ca(2+)-channel activator, FPL 64176.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Antigens, Polyomavirus Transforming; Calcium; Calcium Channel Agonists; Calcium Channels; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Glyburide; Insulin; Insulin Secretion; Insulinoma; Kinetics; Mice; Mice, Transgenic; Pancreatic Neoplasms; Promoter Regions, Genetic; Pyrroles; Simian virus 40; Tumor Cells, Cultured | 1997 |
Interaction of three structurally distinct Ca2+ channel activators with single L-type Ca2+ channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Azocines; Calcium Channel Agonists; Calcium Channels; CHO Cells; Cricetinae; Electrophysiology; Pyrroles | 1999 |
Calcium channel activation and self-biting in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Aggression; Animals; Behavior, Animal; Bites and Stings; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Diltiazem; Ion Channel Gating; Mice; Mice, Inbred C57BL; Nifedipine; Nimodipine; Nitrendipine; Pyrroles; Self-Injurious Behavior | 1999 |
Calcium channel agonists and dystonia in the mouse.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Brain Mapping; Calcium Channel Agonists; Calcium Channels; Dose-Response Relationship, Drug; Dystonia; Electroencephalography; Electromyography; Locomotion; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Neurologic Examination; Pyrroles | 2000 |
Kinetic effects of FPL 64176 on L-type Ca2+ channels in cardiac myocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Agonists; Calcium Channels, L-Type; Heart Ventricles; Kinetics; Male; Myocardium; Pyrroles; Rats; Rats, Sprague-Dawley; Ventricular Function | 2000 |
Voltage-dependent calcium channels in ventricular cells of rainbow trout: effect of temperature changes in vitro.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 8-Bromo Cyclic Adenosine Monophosphate; Adaptation, Physiological; Animals; Barium; Body Temperature; Cadmium; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Cardiotonic Agents; Cold Temperature; Colforsin; Heart Ventricles; In Vitro Techniques; Ion Channel Gating; Isoproterenol; Membrane Potentials; Muscle Fibers, Skeletal; Myocardial Contraction; Myocardium; Nifedipine; Oncorhynchus mykiss; Patch-Clamp Techniques; Pyrroles; Tetrodotoxin | 2000 |
Transmission of information from cardiac dihydropyridine receptor to ryanodine receptor: evidence from BayK 8644 effects on resting Ca(2+) sparks.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Ferrets; Heart; Heart Ventricles; Ion Channel Gating; Membrane Potentials; Microscopy, Confocal; Myocardium; Nifedipine; Pyrroles; Receptor Cross-Talk; Ryanodine Receptor Calcium Release Channel | 2000 |
Phase I and phase II of short-term mechanical restitution in perfused rat left ventricles.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Benzylamines; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Enzyme Inhibitors; Heart; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Perfusion; Pyrroles; Rats; Rats, Sprague-Dawley; Ryanodine; Sarcolemma; Sarcoplasmic Reticulum; Sulfonamides; Systole; Thapsigargin; Time Factors; Vasodilation; Ventricular Function, Left | 2002 |
Modulation of single channels underlying hippocampal L-type current enhancement by agonists depends on the permeant ion.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium; Calcium; Calcium Channel Agonists; Calcium Channels, L-Type; Electric Conductivity; Hippocampus; In Vitro Techniques; Permeability; Pyrroles; Rats; Rats, Sprague-Dawley; Time Factors | 2004 |
FPL 64176 modification of Ca(V)1.2 L-type calcium channels: dissociation of effects on ionic current and gating current.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Biophysics; Calcium Channel Agonists; Calcium Channels; Cell Line; Cesium; Cricetinae; Electrophysiology; Ion Channel Gating; Ions; Kinetics; Membrane Potentials; Models, Theoretical; Plasmids; Potassium Channels; Pyrroles; Rabbits; Time Factors; Transfection | 2005 |
Calcium influx through L-type channels generates protein kinase M to induce burst firing of dopamine cells in the rat ventral tegmental area.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Agonists; Calcium Channels, L-Type; Calpain; Dopamine; Female; Glutamine; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Ventral Tegmental Area | 2007 |
A pharmacological model for calcium overload-induced tachycardia in isolated rat left atria.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Benzazepines; Boron Compounds; Calcium; Calcium Channel Agonists; Cardiotonic Agents; Cyclic Nucleotide-Gated Cation Channels; Heart Atria; In Vitro Techniques; Male; Ouabain; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Ryanodine; Tachycardia | 2007 |
Conformational changes induced in voltage-gated calcium channel Cav1.2 by BayK 8644 or FPL64176 modify the kinetics of secretion independently of Ca2+ influx.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium; Calcium; Calcium Channel Agonists; Calcium Channels, L-Type; Calcium Signaling; Catecholamines; Cattle; Cells, Cultured; Chromaffin Cells; Electrochemical Techniques; Lanthanum; Membrane Potentials; Mutation; Protein Conformation; Protein Subunits; Pyrroles; Rats | 2010 |
An L-type calcium channel agonist, bay K8644, extends the window of intervention against ischemic neuronal injury.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Brain Ischemia; Butadienes; Calcium Channels, L-Type; Extracellular Signal-Regulated MAP Kinases; Maze Learning; Memory; Neurons; Neuroprotective Agents; Nitriles; Phosphorylation; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2013 |
Differential CaMKII regulation by voltage-gated calcium channels in the striatum.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Chelating Agents; Corpus Striatum; Egtazic Acid; Enzyme Inhibitors; Gene Expression Regulation; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Pyrroles; Receptors, Glutamate; Signal Transduction; Spider Venoms | 2015 |