Compounds > fpl 57231
Page last updated: 2024-09-03

fpl 57231 and indomethacin

fpl 57231 has been researched along with indomethacin in 6 studies

Compound Research Comparison

Studies
(fpl 57231)		Trials
(fpl 57231)		Recent Studies (post-2010)
(fpl 57231)		Studies
(indomethacin)		Trials
(indomethacin)		Recent Studies (post-2010) (indomethacin)
300029,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomyfpl 57231 (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19905 (83.33)18.7374
1990's1 (16.67)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Schreiber, MD; Soifer, SJ1
Chen, P; Raj, JU1
Creese, BR; Temple, DM1
Abraham, WM; Codias, E; Hernandez, A; Lanes, S; Sielczak, MW; Stevenson, JS; Wanner, A1
Ahmed, T; Gazeroglu, H; Marchette, B; Muccitelli, R; Tucker, S; Wasserman, MA1
Bancalari, A; Bancalari, E; Goldberg, RN; Hehre, D; Suguihara, C1

Other Studies

6 other study(ies) available for fpl 57231 and indomethacin

ArticleYear
Hemodynamic effects of oleic acid in newborn lambs: role of arachidonic acid metabolites.
    Journal of developmental physiology, 1991, Volume: 16, Issue:3

    Topics: Animals; Animals, Newborn; Arachidonic Acid; Chromones; Hemodynamics; Hypertension, Pulmonary; Indomethacin; Lung; Lung Injury; Oleic Acid; Oleic Acids; Sheep; SRS-A

1991
Role of eicosanoids in hypoxic vasoconstriction in isolated lamb lungs.
    The American journal of physiology, 1987, Volume: 253, Issue:3 Pt 2

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Chromones; Epoprostenol; Hypoxia; Imidazoles; In Vitro Techniques; Indomethacin; Lipoxygenase; Lung; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pulmonary Circulation; Receptors, Leukotriene; Receptors, Prostaglandin; Sheep; SRS-A; Thromboxane B2; Thromboxanes; Vasoconstriction

1987
The mediators of allergic contraction of human airway smooth muscle: a comparison of bronchial and lung parenchymal strip preparations.
    Clinical and experimental pharmacology & physiology, 1986, Volume: 13, Issue:2

    Topics: Bronchi; Chromones; Cromolyn Sodium; Histamine; Humans; Hypersensitivity; In Vitro Techniques; Indomethacin; Leukotriene B4; Lung; Muscle, Smooth; Prostaglandins; SRS-A

1986
Indomethacin and FPL-57231 inhibit antigen-induced airway hyperresponsiveness in sheep.
    Journal of applied physiology (Bethesda, Md. : 1985), 1986, Volume: 61, Issue:3

    Topics: Airway Resistance; Animals; Antigens; Arachidonic Acid; Arachidonic Acids; Bronchi; Chromones; Hypersensitivity; Indomethacin; Neutrophils; Sheep; Therapeutic Irrigation

1986
Endotoxin-induced changes in pulmonary hemodynamics and respiratory mechanics. Role of lipoxygenase and cyclooxygenase products.
    The American review of respiratory disease, 1986, Volume: 134, Issue:6

    Topics: 6-Ketoprostaglandin F1 alpha; Airway Resistance; Animals; Chromones; Cyclooxygenase Inhibitors; Dinoprost; Endotoxins; Escherichia coli; Female; Hemodynamics; Indomethacin; Lipoxygenase; Lung; Prostaglandin-Endoperoxide Synthases; Prostaglandins F; Respiration; Sheep; SRS-A; Thromboxane B2; Time Factors

1986
Effect of cyclooxygenase and lipoxygenase products on pulmonary function in group B streptococcal sepsis.
    Pediatric research, 1987, Volume: 22, Issue:4

    Topics: Animals; Blood Pressure; Chromones; Cyclooxygenase Inhibitors; Indomethacin; Lung; Lung Compliance; Pulmonary Circulation; Pulmonary Gas Exchange; Pulmonary Wedge Pressure; SRS-A; Streptococcal Infections; Streptococcus agalactiae; Swine

1987