fozivudine tidoxil has been researched along with zidovudine in 7 studies
*Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia. [MeSH]
*Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anderson, R; Boerner, D; Diquet, B; Girard, PM; Pegram, PS; Raffi, F; Sereni, D; Tubiana, R | 1 |
| Boerner, D; Bogner, JR; Goebel, FD; Herrmann, DB; Hoegl, L; Jost, V; Mühlhöfer, A; Roecken, M; Thoma-Greber, E | 1 |
| Boerner, D; Bogner, JR; Goebel, FD; Gürtler, L; Herrmann, DB; Kaufmann, B; Plewig, G; Roecken, M | 1 |
| Heckl-Ostreicher, B; Lebrecht, D; Reuss, FU; Venhoff, AC; Venhoff, N; Walker, UA; Wehr, R | 1 |
| Fogle, JE; Miller, MM | 1 |
| Anglaret, X; Danel, C; Eholie, S; Ello, F; Girard, PM; Hoelscher, M; Kroidl, A; Lennemann, T; Maganga, L; Mgaya, J; Moh, R; Pruvost, A; Saathoff, E; von Massow, F; Zuhse, R | 1 |
1 review(s) available for fozivudine tidoxil and zidovudine
| Article | Year |
|---|---|
Fozivudine: BM 211290, fozivudine tidoxil, FZT, HDP 990002, W 09726867.
Topics: Animals; Anti-HIV Agents; Drugs, Investigational; HIV Infections; Humans; Lipids; Zidovudine | 2004 |
4 trial(s) available for fozivudine tidoxil and zidovudine
| Article | Year |
|---|---|
Phase II placebo-controlled trial of fozivudine tidoxil for HIV infection: pharmacokinetics, tolerability, and efficacy.
Topics: Adult; Anti-HIV Agents; Area Under Curve; Dose-Response Relationship, Drug; Double-Blind Method; Female; HIV Infections; HIV-1; Humans; Lipids; Male; Reverse Transcriptase Inhibitors; RNA, Viral; Viral Load; Zidovudine | 2000 |
Single dose, dose-escalating trial with fozivudine tidoxil (BM 21.1290).
Topics: Adult; Anti-HIV Agents; Food; HIV Infections; Humans; Lipids; Male; Middle Aged; Zidovudine | 1997 |
Phase I/II trial with fozivudine tidoxil (BM 21.1290): a 7 day randomized, placebo-controlled dose-escalating trial.
Topics: Adult; Anti-HIV Agents; HIV Infections; Humans; Lipids; Male; Middle Aged; RNA, Viral; Zidovudine | 1997 |
Virological efficacy of 24-week fozivudine-based regimen in ART-naive patients from Tanzania and Côte d'Ivoire.
Topics: Adult; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Cote d'Ivoire; Drug-Related Side Effects and Adverse Reactions; Female; HIV Infections; Humans; Lipids; Male; Middle Aged; Prospective Studies; Sustained Virologic Response; Tanzania; Treatment Outcome; Zidovudine | 2017 |
2 other study(ies) available for fozivudine tidoxil and zidovudine
| Article | Year |
|---|---|
Mitochondrial DNA depletion in rat liver induced by fosalvudine tidoxil, a novel nucleoside reverse transcriptase inhibitor prodrug.
Topics: Animals; Didanosine; DNA, Mitochondrial; Lipids; Liver; Male; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Zidovudine | 2009 |
Administration of Fozivudine tidoxil as a single-agent therapeutic during acute feline immunodeficiency virus infection does not alter chronic infection.
Topics: Animals; Anti-HIV Agents; Cat Diseases; Cats; CD4-CD8 Ratio; Feline Acquired Immunodeficiency Syndrome; Lipids; Lymphocyte Count; Treatment Outcome; Viral Load; Viremia; Zidovudine | 2012 |