fosmidomycin and 3-(n-acetyl-n-hydroxy)aminopropylphosphonic acid

fosmidomycin has been researched along with 3-(n-acetyl-n-hydroxy)aminopropylphosphonic acid in 33 studies

Research

Studies (33)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (6.06)	18.2507
2000's	13 (39.39)	29.6817
2010's	18 (54.55)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Heidler, P; Klebe, G; Kurz, T; Silber, K	1
Beck, E; Goeman, J; Haemers, T; Henschker, D; Jomaa, H; Van Calenbergh, S; Van Poecke, S; Wiesner, J	1
Devreux, V; Goeman, JL; Jomaa, H; Van Calenbergh, S; Van der Eycken, J; Wiesner, J	1
Devreux, V; Jomaa, H; Van Calenbergh, S; Van der Eycken, J; Wiesner, J	1
Giessmann, D; Haemers, T; Hillaert, U; Jomaa, H; Link, A; Ortmann, R; Schlitzer, M; Van Calenbergh, S; Verbrugghen, T; Wiesner, J	1
Cos, P; Maes, L; Van Calenbergh, S; Verbrugghen, T	1
Cheng, G; Deng, L; Endo, K; Kato, M; Song, Y; Yajima, S	1
Chen, P; Cheng, G; Crick, DC; Deng, L; Diao, J; Prasad, BV; Pujari, V; Song, Y; Yao, Y	1
Andaloussi, M; Bergfors, T; Björkelid, C; Henriksson, LM; Iyer, H; Jones, TA; Karlén, A; Larhed, M; Larsson, AM; Lindh, M; Mowbray, SL; Srinivasa, BR; Suresh, S; Unge, T; Więckowska, A	1
Andaloussi, M; Björkelid, C; Iyer, H; Karlén, A; Larhed, M; Lindh, M; Suresh, S; Wieckowska, A	1
Grosdemange-Billiard, C; Ponaire, S; Rohmer, M; Tritsch, D; Zinglé, C	1
Brown, NG; Cai, G; Deng, L; Fryszczyn, BG; Jiang, H; Liu, Z; Palzkill, T; Song, Y	1
Maes, L; Pouyez, J; Van Calenbergh, S; Vandurm, P; Verbrugghen, T; Wouters, J	1
Cai, G; Deng, L; Moreno, SN; Song, Y; Striepen, B; Xue, J	1
Andaloussi, M; Bergfors, T; Björkelid, C; Desroses, M; Dharavath, S; Jansson, AM; Jones, TA; Karlén, A; Larhed, M; Lindh, M; Mowbray, SL; Nikhil, R; Sooriyaarachchi, S; Sreevalli, S; Srinivasa, BR; Suresh, S; Więckowska, A; Yahiaoui, S	1
Boshoff, HI; Brothers, RC; Couch, RD; Dowd, CS; Edelstein, EK; Haymond, A; Jackson, ER; Johny, C; San Jose, G; Sheldon, Z	1
Bacher, A; Behrendt, C; Brücher, K; Fischer, M; Gräwert, T; Held, J; Illarionov, B; Konzuch, S; Kurz, T; Lienau, C; Maes, L; Mordmüller, B; Wittlin, S	1
Alex, A; Bergfors, T; Chofor, R; Coenye, T; Couch, RD; Dowd, CS; Everaert, A; Haymond, A; Johny, C; Jones, TA; Maes, L; Mowbray, SL; Pouyez, J; Risseeuw, MD; Sooriyaarachchi, S; Van Calenbergh, S; Wouters, J	1
Calderón, F; Fernández-Álvaro, E; Hong, WD; Nixon, GL; O'Neill, PM	1
Esque, J; Grosdemange-Billiard, C; Hemmerlin, A; Krebs, F; Munier, M; Rohmer, M; Stote, RH; Tritsch, D	1
Altincicek, B; Beck, E; Eberl, M; Hintz, M; Jomaa, H; Lichtenthaler, HK; Sanderbrand, S; Soldati, D; Türbachova, I; Weidemeyer, C; Wiesner, J; Zeidler, J	1
Ridley, RG	1
Altincicek, B; Beck, E; Hintz, M; Jomaa, H; Sanderbrand, S; Wiesner, J	1
Beck, E; Henschker, D; Jomaa, H; Ortmann, R; Reichenberg, A; Schlitzer, M; Wiesner, J	2
Proteau, PJ	1
Bergmann, B; Geffken, D; Kaula, U; Kurz, T; Schlüter, K; Walter, RD	1
Behrendt, C; Bergmann, B; Kurz, T; Pein, M; Schlüter, K; Walter, RD	1
Basco, LK; Tahar, R	1
Behrendt, C; Bergmann, B; Kaula, U; Kurz, T; Pein, M; Walter, RD	1
DeSieno, MA; van der Donk, WA; Zhao, H	1
Boshoff, HI; Dowd, CS; Jackson, ER; Lee, RE; Maddox, M; San Jose, G; Uh, E	1
Bases, J; Couch, RD; Dowd, CS; Dowdy, T; Haymond, A; Jackson, ER; Johny, C; Mantooth, CJ; Patel, T; San Jose, G; Schweibenz, B; Villarroel, K; Young, R	1

Reviews

2 review(s) available for fosmidomycin and 3-(n-acetyl-n-hydroxy)aminopropylphosphonic acid

Article	Year
Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action. Journal of medicinal chemistry, 2016, 06-23, Volume: 59, Issue:12 Topics: Antimalarials; Biological Products; Chemistry, Pharmaceutical; Humans; Malaria; Molecular Structure	2016
1-Deoxy-D-xylulose 5-phosphate reductoisomerase: an overview. Bioorganic chemistry, 2004, Volume: 32, Issue:6 Topics: Aldose-Ketose Isomerases; Antimalarials; Catalysis; Enzyme Inhibitors; Fosfomycin; Molecular Conformation; Multienzyme Complexes; Oxidoreductases	2004

Other Studies

31 other study(ies) available for fosmidomycin and 3-(n-acetyl-n-hydroxy)aminopropylphosphonic acid

Article	Year
AFMoC enhances predictivity of 3D QSAR: a case study with DOXP-reductoisomerase. Journal of medicinal chemistry, 2005, May-19, Volume: 48, Issue:10 Topics: Aldose-Ketose Isomerases; Antimalarials; Binding Sites; Crystallography, X-Ray; Fosfomycin; Ligands; Models, Molecular; Molecular Structure; Multienzyme Complexes; Oxidoreductases; Protein Binding; Protein Conformation; Quantitative Structure-Activity Relationship	2005
Synthesis of alpha-substituted fosmidomycin analogues as highly potent Plasmodium falciparum growth inhibitors. Bioorganic & medicinal chemistry letters, 2006, Apr-01, Volume: 16, Issue:7 Topics: Animals; Antimalarials; Fosfomycin; Plasmodium falciparum	2006
Synthesis and biological evaluation of cyclopropyl analogues of fosmidomycin as potent Plasmodium falciparum growth inhibitors. Journal of medicinal chemistry, 2006, Apr-20, Volume: 49, Issue:8 Topics: Aldose-Ketose Isomerases; Animals; Escherichia coli; Fosfomycin; In Vitro Techniques; Molecular Structure; Multienzyme Complexes; Oxidoreductases; Parasitic Sensitivity Tests; Plasmodium falciparum; Stereoisomerism; Structure-Activity Relationship	2006
Synthesis and evaluation of alpha,beta-unsaturated alpha-aryl-substituted fosmidomycin analogues as DXR inhibitors. Bioorganic & medicinal chemistry letters, 2007, Sep-01, Volume: 17, Issue:17 Topics: Aldose-Ketose Isomerases; Animals; Antimalarials; Chemistry, Pharmaceutical; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fosfomycin; Inhibitory Concentration 50; Malaria; Models, Chemical; Molecular Structure; Multienzyme Complexes; Oxidoreductases; Plasmodium falciparum; Structure-Activity Relationship	2007
Synthesis of beta- and gamma-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates. Bioorganic & medicinal chemistry, 2008, Mar-15, Volume: 16, Issue:6 Topics: Animals; Antimalarials; Fosfomycin; Parasitic Sensitivity Tests; Plasmodium falciparum; Structure-Activity Relationship	2008
Synthesis and evaluation of alpha-halogenated analogues of 3-(acetylhydroxyamino)propylphosphonic acid (FR900098) as antimalarials. Journal of medicinal chemistry, 2010, Jul-22, Volume: 53, Issue:14 Topics: Acute Disease; Animals; Antimalarials; Fosfomycin; Malaria; Mice; Plasmodium berghei; Plasmodium falciparum; Structure-Activity Relationship	2010
Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes. ACS medicinal chemistry letters, 2011, Feb-10, Volume: 2, Issue:2 Topics:	2011
Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase by lipophilic phosphonates: SAR, QSAR, and crystallographic studies. Journal of medicinal chemistry, 2011, Jul-14, Volume: 54, Issue:13 Topics: Aldose-Ketose Isomerases; Anti-Bacterial Agents; Antitubercular Agents; Crystallography, X-Ray; Escherichia coli; Models, Molecular; Multienzyme Complexes; Mycobacterium tuberculosis; Organophosphonates; Oxidoreductases; Protein Binding; Protein Conformation; Quantitative Structure-Activity Relationship; Structure-Activity Relationship	2011
Design, synthesis, and X-ray crystallographic studies of α-aryl substituted fosmidomycin analogues as inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase. Journal of medicinal chemistry, 2011, Jul-28, Volume: 54, Issue:14 Topics: Aldose-Ketose Isomerases; Antitubercular Agents; Catalytic Domain; Crystallography, X-Ray; Drug Design; Fosfomycin; Models, Molecular; Multienzyme Complexes; Mycobacterium tuberculosis; Oxidoreductases; Protein Binding; Protein Conformation; Structure-Activity Relationship	2011
Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: an attempt to improve the activity against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters, 2011, Sep-15, Volume: 21, Issue:18 Topics: Aldose-Ketose Isomerases; Antitubercular Agents; Crystallography, X-Ray; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fosfomycin; Hydroxamic Acids; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Multienzyme Complexes; Mycobacterium tuberculosis; Organophosphonates; Oxidoreductases; Stereoisomerism; Structure-Activity Relationship	2011
Growth inhibition of Mycobacterium smegmatis by prodrugs of deoxyxylulose phosphate reducto-isomerase inhibitors, promising anti-mycobacterial agents. European journal of medicinal chemistry, 2012, Volume: 51 Topics: Aldose-Ketose Isomerases; Anti-Bacterial Agents; Enzyme Inhibitors; Fosfomycin; Hydrophobic and Hydrophilic Interactions; Kinetics; Microbial Viability; Multienzyme Complexes; Mycobacterium smegmatis; Organophosphonates; Oxazines; Oxidoreductases; Prodrugs; Xanthenes	2012
Thermodynamic Investigation of Inhibitor Binding to 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase. ACS medicinal chemistry letters, 2012, Jun-14, Volume: 3, Issue:6 Topics:	2012
Alpha-heteroatom derivatized analogues of 3-(acetylhydroxyamino)propyl phosphonic acid (FR900098) as antimalarials. Journal of medicinal chemistry, 2013, Jan-10, Volume: 56, Issue:1 Topics: Aldose-Ketose Isomerases; Antimalarials; Erythrocytes; Fosfomycin; Humans; In Vitro Techniques; Molecular Docking Simulation; Parasitic Sensitivity Tests; Plasmodium falciparum; Stereoisomerism; Structure-Activity Relationship	2013
Expression, characterization and inhibition of Toxoplasma gondii 1-deoxy-D-xylulose-5-phosphate reductoisomerase. Bioorganic & medicinal chemistry letters, 2013, Apr-01, Volume: 23, Issue:7 Topics: Aldose-Ketose Isomerases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escherichia coli; Molecular Structure; Plasmodium falciparum; Recombinant Proteins; Structure-Activity Relationship; Toxoplasma	2013
DXR inhibition by potent mono- and disubstituted fosmidomycin analogues. Journal of medicinal chemistry, 2013, Aug-08, Volume: 56, Issue:15 Topics: Aldose-Ketose Isomerases; Antimalarials; Crystallography, X-Ray; Escherichia coli; Fosfomycin; Hydroxamic Acids; Inhibitory Concentration 50; Models, Molecular; Mycobacterium tuberculosis; Plasmodium falciparum; Protein Binding; Protein Conformation; Structure-Activity Relationship	2013
The effect of chain length and unsaturation on Mtb Dxr inhibition and antitubercular killing activity of FR900098 analogs. Bioorganic & medicinal chemistry letters, 2014, Jan-15, Volume: 24, Issue:2 Topics: Antitubercular Agents; Drug Resistance, Multiple, Bacterial; Fosfomycin; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Structure-Activity Relationship	2014
Prodrugs of reverse fosmidomycin analogues. Journal of medicinal chemistry, 2015, Feb-26, Volume: 58, Issue:4 Topics: Animals; Antimalarials; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Fosfomycin; HeLa Cells; Humans; Malaria; Mice; Mice, SCID; Molecular Structure; Plasmodium berghei; Plasmodium falciparum; Prodrugs; Structure-Activity Relationship	2015
Synthesis and bioactivity of β-substituted fosmidomycin analogues targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase. Journal of medicinal chemistry, 2015, Apr-09, Volume: 58, Issue:7 Topics: Aldose-Ketose Isomerases; Antimalarials; Chemistry Techniques, Synthetic; Crystallography, X-Ray; Enzyme Inhibitors; Escherichia coli; Fosfomycin; Inhibitory Concentration 50; Microbial Sensitivity Tests; Models, Molecular; Molecular Targeted Therapy; Mycobacterium tuberculosis; Plasmodium falciparum; Protein Conformation; Structure-Activity Relationship	2015
Synthesis and biological evaluation of phosphate isosters of fosmidomycin and analogs as inhibitors of Escherichia coli and Mycobacterium smegmatis 1-deoxyxylulose 5-phosphate reductoisomerases. Bioorganic & medicinal chemistry, 2017, 01-15, Volume: 25, Issue:2 Topics: Aldose-Ketose Isomerases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escherichia coli; Fosfomycin; Molecular Structure; Mycobacterium smegmatis; Phosphates; Structure-Activity Relationship	2017
Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science (New York, N.Y.), 1999, Sep-03, Volume: 285, Issue:5433 Topics: Aldose-Ketose Isomerases; Amino Acid Sequence; Animals; Antimalarials; Cloning, Molecular; Enzyme Inhibitors; Fosfomycin; Genes, Protozoan; Hemiterpenes; Malaria; Malaria, Falciparum; Mevalonic Acid; Mice; Molecular Sequence Data; Multienzyme Complexes; Organelles; Organophosphorus Compounds; Oxidoreductases; Pentosephosphates; Plasmodium falciparum; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Terpenes	1999
Planting the seeds of new antimalarial drugs. Science (New York, N.Y.), 1999, Sep-03, Volume: 285, Issue:5433 Topics: Aldose-Ketose Isomerases; Animals; Antimalarials; Drug Design; Enzyme Inhibitors; Fosfomycin; Hemiterpenes; Humans; Malaria; Malaria, Falciparum; Mice; Multienzyme Complexes; Organelles; Organophosphorus Compounds; Oxidoreductases; Plasmodium falciparum; Steroids; Transferases	1999
Tools for discovery of inhibitors of the 1-deoxy-D-xylulose 5-phosphate (DXP) synthase and DXP reductoisomerase: an approach with enzymes from the pathogenic bacterium Pseudomonas aeruginosa. FEMS microbiology letters, 2000, Sep-15, Volume: 190, Issue:2 Topics: Aldose-Ketose Isomerases; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Escherichia coli; Fosfomycin; Humans; Molecular Sequence Data; Multienzyme Complexes; Oxidoreductases; Pseudomonas aeruginosa; Pyruvates; Spectrophotometry; Transferases	2000
Acyloxyalkyl ester prodrugs of FR900098 with improved in vivo anti-malarial activity. Bioorganic & medicinal chemistry letters, 2003, Jul-07, Volume: 13, Issue:13 Topics: Animals; Antimalarials; Biological Availability; Fosfomycin; Indicators and Reagents; Lysophospholipids; Malaria; Mevalonic Acid; Mice; Mice, Inbred BALB C; Prodrugs	2003
Alkoxycarbonyloxyethyl ester prodrugs of FR900098 with improved in vivo antimalarial activity. Archiv der Pharmazie, 2005, Volume: 338, Issue:7 Topics: Administration, Oral; Aldose-Ketose Isomerases; Animals; Antimalarials; Biological Availability; Dose-Response Relationship, Drug; Fosfomycin; Malaria; Mice; Mice, Inbred BALB C; Multienzyme Complexes; Oxidoreductases; Plasmodium; Prodrugs; Quantitative Structure-Activity Relationship	2005
Synthesis and antimalarial activity of chain substituted pivaloyloxymethyl ester analogues of Fosmidomycin and FR900098. Bioorganic & medicinal chemistry, 2006, Aug-01, Volume: 14, Issue:15 Topics: Animals; Antimalarials; Dose-Response Relationship, Drug; Fosfomycin; Molecular Structure; Parasitic Sensitivity Tests; Pentanoic Acids; Plasmodium falciparum; Prodrugs; Stereoisomerism; Structure-Activity Relationship	2006
Conformationally restrained aromatic analogues of fosmidomycin and FR900098. Archiv der Pharmazie, 2007, Volume: 340, Issue:7 Topics: Animals; Antimalarials; Esters; Fosfomycin; Inhibitory Concentration 50; Molecular Conformation; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Prodrugs; Structure-Activity Relationship	2007
Molecular epidemiology of malaria in Cameroon. XXV. In vitro activity of fosmidomycin and its derivatives against fresh clinical isolates of Plasmodium falciparum and sequence analysis of 1-deoxy-D-xylulose 5-phosphate reductoisomerase. The American journal of tropical medicine and hygiene, 2007, Volume: 77, Issue:2 Topics: Adolescent; Aldose-Ketose Isomerases; Amino Acid Sequence; Animals; Cameroon; DNA, Protozoan; Enzyme Inhibitors; Fosfomycin; Humans; Malaria, Falciparum; Molecular Epidemiology; Multienzyme Complexes; Oxidoreductases; Parasitic Sensitivity Tests; Plasmodium falciparum; Sequence Alignment; Sequence Analysis, DNA	2007
gamma-Substituted bis(pivaloyloxymethyl)ester analogues of fosmidomycin and FR900098. Archiv der Pharmazie, 2007, Volume: 340, Issue:12 Topics: Animals; Antimalarials; Esters; Fosfomycin; Humans; Parasitic Sensitivity Tests; Plasmodium falciparum; Structure-Activity Relationship	2007
Characterization and application of the Fe(II) and α-ketoglutarate dependent hydroxylase FrbJ. Chemical communications (Cambridge, England), 2011, Sep-28, Volume: 47, Issue:36 Topics: Antimalarials; Bacterial Proteins; Ferrous Compounds; Fosfomycin; Ketoglutaric Acids; Mixed Function Oxygenases; Plasmodium falciparum; Streptomyces	2011
Antibacterial and antitubercular activity of fosmidomycin, FR900098, and their lipophilic analogs. Bioorganic & medicinal chemistry letters, 2011, Dec-01, Volume: 21, Issue:23 Topics: Aldose-Ketose Isomerases; Anti-Bacterial Agents; Antitubercular Agents; Bacteria; Fosfomycin; Lipids; Molecular Structure; Multienzyme Complexes; Mycobacterium tuberculosis; Oxidoreductases; Solubility	2011
Kinetic characterization and allosteric inhibition of the Yersinia pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). PloS one, 2014, Volume: 9, Issue:8 Topics: Aldose-Ketose Isomerases; Allosteric Regulation; Bacterial Proteins; Catalysis; Erythritol; Fosfomycin; Kinetics; Yersinia pestis	2014