foscarnet and pyrophosphate

foscarnet has been researched along with pyrophosphate in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19905 (35.71)18.7374
1990's5 (35.71)18.2507
2000's3 (21.43)29.6817
2010's1 (7.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Löfgren, B; Nordenfelt, E; Oberg, B1
Eriksson, B; Gadler, H; Oberg, B; Rudén, U; Wahren, B1
Hall, MJ1
Gillerman, E; Modak, MJ; Srivastava, A1
Eriksson, B; Oberg, B; Stening, G1
Cheng, YC; Gonzalez, CJ; Im, GJ; Tramontano, E1
Driver, CJ; Vogrig, DJ1
Nonay, RL; Reha-Krantz, LJ; Stocki, S1
Arion, D; Borkow, G; Kaushik, N; McCormick, S; Parniak, MA1
Bazmi, HZ; La Colla, P; Mellors, JW; Piras, G; Putzolu, M; Tramontano, E1
Freissmuth, M; Hohenegger, M; Kleuss, C; Kudlacek, O; Mitterauer, T; Nanoff, C; Tang, WJ1
Bazmi, HZ; Chopra, RR; Matsuura, SE; Mellors, JW; Meyer, PR; Pendarvis, E; Scott, WA; Zonarich, D1
Boivin, G; Gilbert, C; Götte, M; Tchesnokov, EP1
Arnold, E; Balzarini, J; Das, K; DeStefano, JJ; Maguire, AR; Miller, MT1

Other Studies

14 other study(ies) available for foscarnet and pyrophosphate

ArticleYear
Inhibition of RNA- and DNA-dependent duck hepatitis B virus DNA polymerase activity by nucleoside and pyrophosphate analogs.
    Antiviral research, 1989, Volume: 12, Issue:5-6

    Topics: Animals; Antiviral Agents; Chick Embryo; Diphosphates; DNA-Directed DNA Polymerase; Foscarnet; Hepatitis B Virus, Duck; Nucleic Acid Synthesis Inhibitors; Nucleotides; Phosphonoacetic Acid; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase

1989
Activity of the cytomegalovirus genome in the presence of PPi analogs.
    Journal of virology, 1985, Volume: 56, Issue:3

    Topics: Antiviral Agents; Cells, Cultured; Cytomegalovirus; Diphosphates; DNA Replication; DNA, Viral; Foscarnet; Humans; Nucleic Acid Synthesis Inhibitors; Organophosphorus Compounds; Phosphonoacetic Acid; Structure-Activity Relationship; Viral Proteins; Virus Replication

1985
Anti-herpes virus combinations in relation to drug resistance.
    The Journal of antimicrobial chemotherapy, 1986, Volume: 18 Suppl B

    Topics: Acyclovir; Adenosine Deaminase Inhibitors; Animals; Antiviral Agents; Diphosphates; Drug Resistance, Microbial; Drug Synergism; Drug Therapy, Combination; Foscarnet; Herpes Simplex; In Vitro Techniques; Nucleic Acid Synthesis Inhibitors; Phosphonoacetic Acid; Simplexvirus; Thymidine Kinase; Uridine Phosphorylase; Vidarabine

1986
Observations on the phosphonoformic acid inhibition of RNA dependent DNA polymerases.
    Biochemical and biophysical research communications, 1980, Sep-30, Volume: 96, Issue:2

    Topics: Diphosphates; Endonucleases; Foscarnet; Nucleic Acid Synthesis Inhibitors; Organophosphorus Compounds; Phosphonoacetic Acid; Pyridoxal Phosphate; Reverse Transcriptase Inhibitors; Ribonuclease H; Ribonucleases; Templates, Genetic

1980
Inhibition of reverse transcriptase activity of avian myeloblastosis virus by pyrophosphate analogues.
    Antiviral research, 1982, Volume: 2, Issue:1-2

    Topics: Avian Leukosis Virus; Avian Myeloblastosis Virus; Diphosphates; Diphosphonates; DNA Polymerase II; Foscarnet; Kinetics; Phosphonoacetic Acid; Polydeoxyribonucleotides; Reverse Transcriptase Inhibitors; Structure-Activity Relationship

1982
Identification of the amino acid in the human immunodeficiency virus type 1 reverse transcriptase involved in the pyrophosphate binding of antiviral nucleoside triphosphate analogs and phosphonoformate. Implications for multiple drug resistance.
    Biochemical pharmacology, 1993, Dec-14, Volume: 46, Issue:12

    Topics: Amino Acids; Antiviral Agents; Binding Sites; Dideoxynucleotides; Diphosphates; Drug Resistance, Microbial; Foscarnet; HIV Reverse Transcriptase; HIV-1; Kinetics; Recombinant Proteins; RNA-Directed DNA Polymerase; Thymine Nucleotides; Zidovudine

1993
Apparent retardation of aging in Drosophila melanogaster by inhibitors of reverse transcriptase.
    Annals of the New York Academy of Sciences, 1994, Jun-30, Volume: 717

    Topics: Aging; Animals; Dideoxyadenosine; Diphosphates; DNA Transposable Elements; Drosophila melanogaster; Feeding Behavior; Foscarnet; Life Expectancy; Oxalates; Reverse Transcriptase Inhibitors

1994
Bacteriophage T4 DNA polymerase mutations that confer sensitivity to the PPi analog phosphonoacetic acid.
    Journal of virology, 1993, Volume: 67, Issue:1

    Topics: Bacteriophage T4; Binding Sites; Dideoxynucleosides; Diphosphates; DNA Mutational Analysis; DNA Polymerase II; DNA Replication; DNA, Viral; Dose-Response Relationship, Drug; Foscarnet; Phosphonoacetic Acid; Structure-Activity Relationship

1993
Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase.
    Biochemistry, 1998, Nov-10, Volume: 37, Issue:45

    Topics: Catalysis; Diphosphates; DNA, Viral; Drug Resistance, Microbial; Foscarnet; HIV Reverse Transcriptase; HIV-1; Mutagenesis, Site-Directed; Peptide Chain Termination, Translational; Phenotype; Polymers; Protein Processing, Post-Translational; Reverse Transcriptase Inhibitors; Templates, Genetic; Zidovudine

1998
Biochemical characterization of HIV-1 reverse transcriptases encoding mutations at amino acid residues 161 and 208 involved in resistance to phosphonoformate.
    Biochemical pharmacology, 1998, Dec-15, Volume: 56, Issue:12

    Topics: Amino Acids; Diphosphates; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Stability; Foscarnet; HIV Reverse Transcriptase; Kinetics; Mutagenesis, Site-Directed; Nevirapine; Recombinant Proteins; Reverse Transcriptase Inhibitors; Zidovudine

1998
Inhibition of adenylyl and guanylyl cyclase isoforms by the antiviral drug foscarnet.
    The Journal of biological chemistry, 2001, Feb-02, Volume: 276, Issue:5

    Topics: Adenylyl Cyclase Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Cells, Cultured; Cricetinae; Cyclic AMP; Cyclic GMP; Cyclophosphamide; Dimerization; Diphosphates; Doxorubicin; Enzyme Inhibitors; Foscarnet; GTP-Binding Protein alpha Subunits, Gs; Guanylate Cyclase; Humans; Isoenzymes; Membrane Proteins; Vincristine

2001
Relationship between 3'-azido-3'-deoxythymidine resistance and primer unblocking activity in foscarnet-resistant mutants of human immunodeficiency virus type 1 reverse transcriptase.
    Journal of virology, 2003, Volume: 77, Issue:11

    Topics: Antiviral Agents; Binding Sites; Cell Line; Deoxyadenine Nucleotides; Dideoxynucleotides; Diphosphates; DNA Primers; Drug Resistance, Viral; Foscarnet; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Templates, Genetic; Thymine Nucleotides; Zidovudine

2003
Role of helix P of the human cytomegalovirus DNA polymerase in resistance and hypersusceptibility to the antiviral drug foscarnet.
    Journal of virology, 2006, Volume: 80, Issue:3

    Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Antiviral Agents; Base Sequence; Binding Sites; Cytomegalovirus; Diphosphates; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Viral; Enzyme Inhibitors; Foscarnet; Humans; In Vitro Techniques; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Nucleic Acid Synthesis Inhibitors; Protein Structure, Secondary; Rabbits; Sequence Homology, Amino Acid

2006
Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis-Binding of Foscarnet.
    ACS chemical biology, 2016, 08-19, Volume: 11, Issue:8

    Topics: Crystallography, X-Ray; Diphosphates; Drug Design; Foscarnet; HIV Reverse Transcriptase; Hydrolysis; Nucleotides; Protein Conformation; Reverse Transcriptase Inhibitors

2016