fosbretabulin has been researched along with quinoline* in 3 studies
3 other study(ies) available for fosbretabulin and quinoline
| Article | Year |
|---|---|
Design, synthesis and biological evaluation of novel acridine and quinoline derivatives as tubulin polymerization inhibitors with anticancer activities.
Topics: Acridines; Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Polymerization; Quinolines; Structure-Activity Relationship; Tubulin; Tubulin Modulators; Tumor Cells, Cultured | 2021 |
Synthesis and biological evaluation of quinoline analogues of flavones as potential anticancer agents and tubulin polymerization inhibitors.
A new series of 2-aryl-trimethoxyquinoline analogues was designed and synthesized as tubulin inhibitors using methoxylated flavones as the lead compounds. The cytotoxic activity of the synthesized compounds was evaluated against four human cancer cell lines including MCF-7, MCF-7/MX, A-2780, and A-2780/RCIS. All the alcoholic derivatives (6a-6e) showed significant cytotoxic activity with IC50 in the range of 7.98-60 μM. The flow cytometry analysis of the four human cancer cell lines treated with 6e and 5b showed that 6e induced cell cycle arrest at G2/M phase and apoptosis as well. The effect of quinolines on tubulin polymerization was also evaluated. Compound 6e that demonstrated the best antiproliferative activity in the series was identified as the most potent inhibitor of tubulin polymerization as well. Molecular docking studies of 6e into the colchicine-binding site of tubulin displayed possible mode of interaction between this compound and tubulin. Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Proliferation; Dose-Response Relationship, Drug; Flavones; Humans; Models, Molecular; Molecular Structure; Polymerization; Quinolines; Structure-Activity Relationship; Tubulin; Tubulin Modulators; Tumor Cells, Cultured | 2016 |
A new family of quinoline and quinoxaline analogues of combretastatins.
The 3-hydroxy-4-methoxyphenyl ring of combretastatin A-4 can be replaced by a 2-naphthyl moiety without significant loss of cytotoxicity and inhibition of tubulin polymerization potency. In this paper we show that the 6- or 7-quinolyl systems can in turn replace both cyclic moieties, keeping in the first case most of the potency as cytotoxic agent and in the second case as inhibitor of tubulin polymerization, related to the activities displayed by model compounds. Topics: Antineoplastic Agents; Biopolymers; Cell Line, Tumor; Humans; Inhibitory Concentration 50; Ligands; Naphthalenes; Quinolines; Quinoxalines; Stilbenes; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2004 |