Page last updated: 2024-09-03

fosamprenavir and nelfinavir

fosamprenavir has been researched along with nelfinavir in 12 studies

Compound Research Comparison

Studies (fosamprenavir)	Trials (fosamprenavir)	Recent Studies (post-2010) (fosamprenavir)	Studies (nelfinavir)	Trials (nelfinavir)	Recent Studies (post-2010) (nelfinavir)
174	55	37	1,240	230	240

Protein Interaction Comparison

Protein	Taxonomy	nelfinavir (IC50)
Tyrosine-protein kinase Fyn	Homo sapiens (human)	7.971
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	8.852
ATP-dependent translocase ABCB1	Homo sapiens (human)	3.3938
Cytochrome P450 3A4	Homo sapiens (human)	1.275
ATP-dependent translocase ABCB1	Mus musculus (house mouse)	2.3
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	8.852
Protease	Human immunodeficiency virus 1	0.53
Protease	Human immunodeficiency virus 1	0.0054

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	10 (83.33)	29.6817
2010's	2 (16.67)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Babusis, D; Bhoopathy, S; Hidalgo, IJ; Phan, TK; Ray, AS; Rhodes, GR; Robinson, KL; Strab, R; Tong, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Boghossian, J; Gray, GE; Millard, JM; Nadler, JP; Quinones, AR; Rodriguez-French, A; Sepulveda, GE; Wannamaker, PG	1
DeGoey, DA; Randolph, JT	1
Bellos, NC; DeJesus, E; Garris, C; Gathe, JC; Gladysz, A; Ive, P; Schürmann, D; Wood, R; Yeo, J	1
Adams, E; Hoogmartens, J; Van Schepdael, A; Yekkala, R	1
Adani, GL; Bresadola, V; Furlanut, M; Londero, A; Pavan, F; Pea, F; Tavio, M; Viale, P	1
Fessel, WJ; Hellinger, J; Kaufman, D; Rhee, SY; Ruane, P; Shafer, RW; Shirvani, V; Taylor, J; Towner, W; Troia, P; Zolopa, A	1

Reviews

3 review(s) available for fosamprenavir and nelfinavir

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Peptidomimetic inhibitors of HIV protease. Current topics in medicinal chemistry, 2004, Volume: 4, Issue:10 Topics: Anti-HIV Agents; Atazanavir Sulfate; Carbamates; Clinical Trials as Topic; Dipeptides; Furans; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Lopinavir; Models, Molecular; Molecular Mimicry; Molecular Structure; Nelfinavir; Oligopeptides; Organophosphates; Peptides; Phenylbutyrates; Pyridines; Pyrimidinones; Ritonavir; Saquinavir; Sulfonamides; Urethane	2004
Quality control of protease inhibitors. Journal of pharmaceutical sciences, 2008, Volume: 97, Issue:6 Topics: Anti-HIV Agents; Atazanavir Sulfate; Carbamates; Chromatography, Liquid; Darunavir; Drug Contamination; Furans; HIV Protease Inhibitors; Indinavir; Lopinavir; Nelfinavir; Oligopeptides; Organophosphates; Pyridines; Pyrimidinones; Pyrones; Quality Control; Ritonavir; Saquinavir; Sulfonamides	2008

Trials

2 trial(s) available for fosamprenavir and nelfinavir

Article	Year
The NEAT study: a 48-week open-label study to compare the antiviral efficacy and safety of GW433908 versus nelfinavir in antiretroviral therapy-naive HIV-1-infected patients. Journal of acquired immune deficiency syndromes (1999), 2004, Jan-01, Volume: 35, Issue:1 Topics: Adolescent; Adult; Aged; Anti-HIV Agents; Carbamates; CD4 Lymphocyte Count; Dideoxynucleosides; Drug Therapy, Combination; Female; Furans; HIV Infections; HIV-1; Humans; Lamivudine; Male; Middle Aged; Nelfinavir; Organophosphates; Reverse Transcriptase Inhibitors; RNA, Viral; Sulfonamides	2004
SOLO: 48-week efficacy and safety comparison of once-daily fosamprenavir /ritonavir versus twice-daily nelfinavir in naive HIV-1-infected patients. AIDS (London, England), 2004, Jul-23, Volume: 18, Issue:11 Topics: Adolescent; Adult; Aged; Carbamates; Female; Furans; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Male; Middle Aged; Nelfinavir; Organophosphates; Patient Compliance; Ritonavir; Sulfonamides	2004

Article

Year

The NEAT study: a 48-week open-label study to compare the antiviral efficacy and safety of GW433908 versus nelfinavir in antiretroviral therapy-naive HIV-1-infected patients.

Journal of acquired immune deficiency syndromes (1999), 2004, Jan-01, Volume: 35, Issue:1

Topics: Adolescent; Adult; Aged; Anti-HIV Agents; Carbamates; CD4 Lymphocyte Count; Dideoxynucleosides; Drug Therapy, Combination; Female; Furans; HIV Infections; HIV-1; Humans; Lamivudine; Male; Middle Aged; Nelfinavir; Organophosphates; Reverse Transcriptase Inhibitors; RNA, Viral; Sulfonamides

2004

SOLO: 48-week efficacy and safety comparison of once-daily fosamprenavir /ritonavir versus twice-daily nelfinavir in naive HIV-1-infected patients.

AIDS (London, England), 2004, Jul-23, Volume: 18, Issue:11

Topics: Adolescent; Adult; Aged; Carbamates; Female; Furans; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Male; Middle Aged; Nelfinavir; Organophosphates; Patient Compliance; Ritonavir; Sulfonamides

2004

Other Studies

7 other study(ies) available for fosamprenavir and nelfinavir

Article	Year
Effects of human immunodeficiency virus protease inhibitors on the intestinal absorption of tenofovir disoproxil fumarate in vitro. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:10 Topics: Adenine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Cell Line; Chromatography, High Pressure Liquid; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Drug Interactions; Epithelium; HIV Protease Inhibitors; Humans; Hydrolysis; Indicators and Reagents; Intestinal Absorption; Mass Spectrometry; Organophosphonates; Subcellular Fractions; Tenofovir	2007
Phase III trials for new PI. AIDS patient care and STDs, 2001, Volume: 15, Issue:3 Topics: Antiretroviral Therapy, Highly Active; Carbamates; Chemistry, Pharmaceutical; Clinical Trials, Phase III as Topic; Dideoxynucleosides; Furans; HIV Protease Inhibitors; Humans; Lamivudine; Multicenter Studies as Topic; Nelfinavir; Organophosphates; Prodrugs; Randomized Controlled Trials as Topic; Sulfonamides	2001
SOLO trial results released. AIDS patient care and STDs, 2003, Volume: 17, Issue:2 Topics: Carbamates; Clinical Trials as Topic; Drug Administration Schedule; Drug Therapy, Combination; Furans; HIV Infections; Humans; Nelfinavir; Organophosphates; Protease Inhibitors; Ritonavir; Sulfonamides	2003
NEAT trial releases results. AIDS patient care and STDs, 2002, Volume: 16, Issue:12 Topics: Carbamates; Furans; HIV Infections; Humans; Multicenter Studies as Topic; Nelfinavir; Organophosphates; Prodrugs; Protease Inhibitors; Randomized Controlled Trials as Topic; Sulfonamides; Treatment Outcome; Viral Load	2002
[No selection of mutations. 908 raises genetic resistance barrier]. MMW Fortschritte der Medizin, 2003, Apr-28, Volume: 145 Spec No 1 Topics: Acquired Immunodeficiency Syndrome; Carbamates; DNA Mutational Analysis; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Furans; HIV Protease; HIV Protease Inhibitors; HIV Reverse Transcriptase; Humans; Nelfinavir; Organophosphates; Sulfonamides; Virus Replication	2003
Drop in trough blood concentrations of tacrolimus after switching from nelfinavir to fosamprenavir in four HIV-infected liver transplant patients. Antiviral therapy, 2008, Volume: 13, Issue:5 Topics: Adult; Carbamates; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Female; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Immunosuppressive Agents; Liver Transplantation; Male; Middle Aged; Nelfinavir; Organophosphates; Sulfonamides; Tacrolimus	2008
HIV-1 protease mutations and protease inhibitor cross-resistance. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:10 Topics: Atazanavir Sulfate; Carbamates; Darunavir; Furans; HIV Protease; HIV Protease Inhibitors; HIV-1; Indinavir; Least-Squares Analysis; Lopinavir; Mutation; Nelfinavir; Oligopeptides; Organophosphates; Polymorphism, Genetic; Pyridines; Pyrimidinones; Pyrones; Saquinavir; Sulfonamides	2010