formycins and nebularine

formycins has been researched along with nebularine* in 2 studies

Other Studies

2 other study(ies) available for formycins and nebularine

Article	Year
The design and synthesis of inhibitors of adenosine 5'-monophosphate deaminase. Bioorganic & medicinal chemistry letters, 1999, Jul-19, Volume: 9, Issue:14 Carbocylic coformycin (4) is a potent herbicide whose primary mode of action involves inhibition of adenosine 5'-monophosphate deaminase (AMPDA) following phosphorylation of the 5'-hydroxyl group in vivo. The search for more stable and accessible structures led to the synthesis of carbocyclic nebularine (8) and deaminoformycin (10). The latter compound is a good herbicide and its corresponding 5'-monophosphate 14 is a strong inhibitor of plant AMPDA (IC50 100 nM). Topics: Adenosine; Adenosine Triphosphate; AMP Deaminase; Coformycin; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Formycins; Herbicides; Inhibitory Concentration 50; Phosphorylation; Purine Nucleosides; Ribonucleosides; Structure-Activity Relationship	1999
Inhibition of axenically grown Entamoeba histolytica by purine nucleoside analogs and actions of natural nucleosides. Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), 1991, Volume: 42, Issue:3 The effects of the nucleoside analogs tubercidin, nebularin, formycin B and 3'-deoxyinosine on axenically grown Entamoeba histolytica were tested. Both tubercidin and nebularin showed pronounced inhibitory action, 50% of growth inhibition (IC50) being obtained at 0.14 and 0.82 microM, respectively. Formycin B and 3'-deoxyinosine were essentially inactive or weakly active at concentrations above 10 microM. Natural nucleosides, including adenosine, inosine, guanosine, thymidine, uridine and cytidine caused no significant effects at concentrations of 0.01-1 microM, however, significant inhibitory action was observed at or above 10 microM with cytidine and thymidine. The exploration of cytotoxic nucleosides as antiamebal drugs is of continued interest. Topics: Animals; Anti-Bacterial Agents; Antiprotozoal Agents; Entamoeba histolytica; Formycins; Inosine; Molecular Structure; Purine Nucleosides; Ribonucleosides; Tubercidin	1991

Article

Year

The design and synthesis of inhibitors of adenosine 5'-monophosphate deaminase.

Bioorganic & medicinal chemistry letters, 1999, Jul-19, Volume: 9, Issue:14

Carbocylic coformycin (4) is a potent herbicide whose primary mode of action involves inhibition of adenosine 5'-monophosphate deaminase (AMPDA) following phosphorylation of the 5'-hydroxyl group in vivo. The search for more stable and accessible structures led to the synthesis of carbocyclic nebularine (8) and deaminoformycin (10). The latter compound is a good herbicide and its corresponding 5'-monophosphate 14 is a strong inhibitor of plant AMPDA (IC50 100 nM).

Topics: Adenosine; Adenosine Triphosphate; AMP Deaminase; Coformycin; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Formycins; Herbicides; Inhibitory Concentration 50; Phosphorylation; Purine Nucleosides; Ribonucleosides; Structure-Activity Relationship

1999

Inhibition of axenically grown Entamoeba histolytica by purine nucleoside analogs and actions of natural nucleosides.

Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), 1991, Volume: 42, Issue:3

The effects of the nucleoside analogs tubercidin, nebularin, formycin B and 3'-deoxyinosine on axenically grown Entamoeba histolytica were tested. Both tubercidin and nebularin showed pronounced inhibitory action, 50% of growth inhibition (IC50) being obtained at 0.14 and 0.82 microM, respectively. Formycin B and 3'-deoxyinosine were essentially inactive or weakly active at concentrations above 10 microM. Natural nucleosides, including adenosine, inosine, guanosine, thymidine, uridine and cytidine caused no significant effects at concentrations of 0.01-1 microM, however, significant inhibitory action was observed at or above 10 microM with cytidine and thymidine. The exploration of cytotoxic nucleosides as antiamebal drugs is of continued interest.

Topics: Animals; Anti-Bacterial Agents; Antiprotozoal Agents; Entamoeba histolytica; Formycins; Inosine; Molecular Structure; Purine Nucleosides; Ribonucleosides; Tubercidin

1991