formycins has been researched along with nebularine* in 2 studies
2 other study(ies) available for formycins and nebularine
Article | Year |
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The design and synthesis of inhibitors of adenosine 5'-monophosphate deaminase.
Carbocylic coformycin (4) is a potent herbicide whose primary mode of action involves inhibition of adenosine 5'-monophosphate deaminase (AMPDA) following phosphorylation of the 5'-hydroxyl group in vivo. The search for more stable and accessible structures led to the synthesis of carbocyclic nebularine (8) and deaminoformycin (10). The latter compound is a good herbicide and its corresponding 5'-monophosphate 14 is a strong inhibitor of plant AMPDA (IC50 100 nM). Topics: Adenosine; Adenosine Triphosphate; AMP Deaminase; Coformycin; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Formycins; Herbicides; Inhibitory Concentration 50; Phosphorylation; Purine Nucleosides; Ribonucleosides; Structure-Activity Relationship | 1999 |
Inhibition of axenically grown Entamoeba histolytica by purine nucleoside analogs and actions of natural nucleosides.
The effects of the nucleoside analogs tubercidin, nebularin, formycin B and 3'-deoxyinosine on axenically grown Entamoeba histolytica were tested. Both tubercidin and nebularin showed pronounced inhibitory action, 50% of growth inhibition (IC50) being obtained at 0.14 and 0.82 microM, respectively. Formycin B and 3'-deoxyinosine were essentially inactive or weakly active at concentrations above 10 microM. Natural nucleosides, including adenosine, inosine, guanosine, thymidine, uridine and cytidine caused no significant effects at concentrations of 0.01-1 microM, however, significant inhibitory action was observed at or above 10 microM with cytidine and thymidine. The exploration of cytotoxic nucleosides as antiamebal drugs is of continued interest. Topics: Animals; Anti-Bacterial Agents; Antiprotozoal Agents; Entamoeba histolytica; Formycins; Inosine; Molecular Structure; Purine Nucleosides; Ribonucleosides; Tubercidin | 1991 |