formycin and isoguanosine

formycin has been researched along with isoguanosine* in 1 studies

Other Studies

1 other study(ies) available for formycin and isoguanosine

Article	Year
Novel dinucleoside 5',5'-triphosphate cap analogues. Synthesis and affinity for murine translation factor eIF4E. Nucleosides, nucleotides & nucleic acids, 2005, Volume: 24, Issue:5-7 Chemical synthesis of a series of novel dinucleoside cap analogues, m7GpppN, where N is formycin A, 3'-O-methylguanosine, 9-beta-D-arabinofuranosyladenine, and isoguanosine, has been performed using our new methodology. The key reactions of pyrophosphate bonds formation were achieved in anhydrous dimethylformamide solutions employing the catalytic properties of zinc salts. Structures of the new cap analogues were confirmed by 1H NMR and 31p NMR spectra. The binding affinity of the new cap analogues for murine eIF4E(28-217) were determined spectroscopically showing the highest association constant for the analogue that contains formycin A. Topics: Adenosine; Animals; Dose-Response Relationship, Drug; Eukaryotic Initiation Factor-4E; Formycins; Guanosine; Kinetics; Magnetic Resonance Spectroscopy; Mice; Models, Chemical; Nucleosides; Nucleotides; Protein Binding; RNA Cap Analogs; Spectrophotometry; Thermodynamics; Vidarabine	2005

Article

Year

Novel dinucleoside 5',5'-triphosphate cap analogues. Synthesis and affinity for murine translation factor eIF4E.

Nucleosides, nucleotides & nucleic acids, 2005, Volume: 24, Issue:5-7

Chemical synthesis of a series of novel dinucleoside cap analogues, m7GpppN, where N is formycin A, 3'-O-methylguanosine, 9-beta-D-arabinofuranosyladenine, and isoguanosine, has been performed using our new methodology. The key reactions of pyrophosphate bonds formation were achieved in anhydrous dimethylformamide solutions employing the catalytic properties of zinc salts. Structures of the new cap analogues were confirmed by 1H NMR and 31p NMR spectra. The binding affinity of the new cap analogues for murine eIF4E(28-217) were determined spectroscopically showing the highest association constant for the analogue that contains formycin A.

Topics: Adenosine; Animals; Dose-Response Relationship, Drug; Eukaryotic Initiation Factor-4E; Formycins; Guanosine; Kinetics; Magnetic Resonance Spectroscopy; Mice; Models, Chemical; Nucleosides; Nucleotides; Protein Binding; RNA Cap Analogs; Spectrophotometry; Thermodynamics; Vidarabine

2005