formiminoglutamic-acid has been researched along with 2-methylhippuric-acid* in 1 studies
1 other study(ies) available for formiminoglutamic-acid and 2-methylhippuric-acid
Article | Year |
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Quantification of urinary zwitterionic organic acids using weak-anion exchange chromatography with tandem MS detection.
A rapid and accurate quantitative method was developed and validated for the analysis of four urinary organic acids with nitrogen containing functional groups, formiminoglutamic acid (FIGLU), pyroglutamic acid (PYRGLU), 5-hydroxyindoleacetic acid (5-HIAA), and 2-methylhippuric acid (2-METHIP) by liquid chromatography tandem mass spectrometry (LC/MS/MS). The chromatography was developed using a weak anion-exchange amino column that provided mixed-mode retention of the analytes. The elution gradient relied on changes in mobile phase pH over a concave gradient, without the use of counter-ions or concentrated salt buffers. A simple sample preparation was used, only requiring the dilution of urine prior to instrumental analysis. The method was validated based on linearity (r2>or=0.995), accuracy (85-115%), precision (C.V.<12%), sample preparation stability ( Topics: Acids; Adolescent; Adult; Aged; Aged, 80 and over; Anion Exchange Resins; Chromatography, Ion Exchange; Formiminoglutamic Acid; Hippurates; Humans; Middle Aged; Molecular Structure; Organic Chemicals; Pyrrolidonecarboxylic Acid; Reproducibility of Results; Tandem Mass Spectrometry | 2007 |