formaldehyde has been researched along with morphine in 296 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 42 (14.19) | 18.7374 |
| 1990's | 98 (33.11) | 18.2507 |
| 2000's | 100 (33.78) | 29.6817 |
| 2010's | 51 (17.23) | 24.3611 |
| 2020's | 5 (1.69) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Giagnoni, G; Gori, E; Marsi, A; Parolaro, D; Sala, M | 1 |
| North, MA | 1 |
| Harada, T; Inoki, R; Kaya, H; Takahashi, H | 1 |
| Matsubara, T; Tochino, Y; Touchi, A | 1 |
| Dennis, SG; Dubuisson, D | 1 |
| Needham, LL; Rollen, ZJ; Yert, AW | 1 |
| Agnati, L; Bolme, P; Everitt, BJ; Fuxe, K; Hökfelt, T; Jonsson, G; Ljungdahl, A; Löfström, A | 1 |
| Liebeskind, JC; Marek, P; Sternberg, W; Vaccarino, AL | 1 |
| Aigouy, L; Fondras, JC; Pajot, J; Schoeffler, P; Woda, A | 1 |
| Hart, SL; Oluyomi, AO; Smith, TW | 1 |
| Franklin, KBJ; Matthies, BK | 1 |
| Clarke, PB; Franklin, KB | 1 |
| Franklin, KB; Morgan, MJ | 2 |
| Basbaum, AI; Levine, JD; Menétrey, D; Presley, RW | 1 |
| Hutchison, WD; Morton, CR | 1 |
| Ono, M; Satoh, T | 1 |
| Dickenson, A; Dray, A | 1 |
| Berge, OG; Furset, K; Garcia-Cabrera, I | 1 |
| Cowan, A; Wheeler-Aceto, H | 2 |
| Abbott, FV | 1 |
| Cohen, SR; Kimes, AS; London, ED | 1 |
| Rees, H; Roberts, MHT; Wilson, DG | 1 |
| Hughes, RA; Sufka, KJ | 1 |
| Cramer, CP; Fanselow, MS; Lichtman, AH; McLaughlin, CR | 1 |
| Baumeister, AA; Chatellier, MO; Hawkins, MF; Hebert, G; Nagy, M; Vaughn, A | 1 |
| Hole, K; Mæhle, B; Rosland, JH; Tjølsen, A | 1 |
| Hole, K; Hunskaar, S; Rosland, JH | 2 |
| Abbott, FV; Young, SN | 1 |
| Goldstein, BD; McCarson, KE | 1 |
| Inoki, R; Ohkubo, T; Shibata, M; Takahashi, H | 1 |
| Ansuategui, M; Feria, M; Naharro, L | 1 |
| Cowan, A; Ianone, M; Porreca, F; Wheeler, H | 1 |
| Cowan, A; Porreca, F; Wheeler, H | 1 |
| Bustamante, D; Miranda, HF; Paeile, C; Pelissier, T | 1 |
| Clavelou, P; Dallel, R; Pajot, J; Raboisson, P | 1 |
| Iguchi, Y; Kishioka, S; Ozaki, M; Tamura, S; Yamamoto, H | 1 |
| Cowan, A; Murray, CW; Porreca, F | 1 |
| Aya, K; Inase, M; Nakahama, H; Shima, K; Yamamoto, M | 1 |
| Hole, K; Hunskaar, S | 1 |
| Chin, S; Du Pen, SL; Ramsey, D | 1 |
| Black, KA; Coffman, BL; Dannan, GA; Green, MD; Guengerich, FP; Tephly, TR | 1 |
| Abbott, FV; Franklin, KB | 1 |
| Fasmer, OB; Hole, K; Hunskaar, S | 1 |
| Franklin, M | 1 |
| Gillette, JR; Kato, R | 1 |
| Brown, JH; Kissel, JW; Lish, PM | 1 |
| Hálek, J; Jezdinský, J | 1 |
| Auterhoff, H; Braun, D | 1 |
| Cimbura, G; Kofoed, J | 1 |
| Mannering, GJ; Sladek, NE | 1 |
| Alreja, M; Manchanda, SK; Mutalik, P; Nayar, U | 1 |
| Naruse, S; Ohkubo, T; Shibata, M; Takahashi, H | 1 |
| Abbott, FV; Grimes, RW; Melzack, R | 1 |
| Dennis, SG; Melzack, R | 1 |
| Abbott, FV; Melzack, R; Samuel, C | 1 |
| Hirota, N; Kuraishi, Y; Sugimoto, M; Takagi, H | 1 |
| Abbott, FV; Leber, BF; Melzack, R | 1 |
| Abbott, FV; Franklin, KB; Ludwick, RJ; Melzack, R | 1 |
| Keppler, BR; Manders, WW | 1 |
| Goldstein, BD; Holland, LN | 1 |
| Berger, F; Chayvialle, JA; Chéry-Croze, S; Gorry, F; Miampamba, M | 1 |
| Krause, JE; McCarson, KE | 1 |
| Fuchs, PN; Melzack, R | 1 |
| Kaneto, H; Rahman, AF; Takahashi, M | 4 |
| Carruette, A; Garret, C; Moussaoui, S | 1 |
| Malmberg, AB; Yaksh, TL | 3 |
| Abbott, FV; Franklin, KBJ; Westbrook, FR | 1 |
| Blommaert, A; Fournié-Zaluski, MC; Noble, F; Roques, BP | 1 |
| Franklin, KB; Matthies, BK | 1 |
| Cadet, R; Luccarini, P; Saade, M; Woda, A | 1 |
| Ayala, J; Del Valle, M; Fuente, T; Hernández, LC; Iglesias, L; López, JM; Seijo, F | 1 |
| Chorney, DA; Vaccarino, AL | 1 |
| Franklin, KB; Manning, BH; Morgan, MJ | 1 |
| Abram, SE; O'Connor, TC | 1 |
| Chapman, V; Dickenson, AH; Haley, JE | 1 |
| Basbaum, AI; Jasmin, L; Levine, JD; Tarczy-Hornoch, K; Wang, H | 1 |
| Abram, SE; Olson, EE | 1 |
| Barnes, JC; Blatt, T; Connell, BJ; Tasker, RA | 1 |
| Franklin, KB; Olmstead, MC | 1 |
| Gurtu, S; Mukerjee, D; Shukla, S | 1 |
| Calixto, JB; Corrêa, CR | 1 |
| Ben-Eliyahu, S; Couret, LC; Kao, B; Kest, B; Liebeskind, JC; Marek, P; Vaccarino, AL | 1 |
| Bustamante, D; Paeile, C | 1 |
| Coderre, TJ; Dalal, S; Fundytus, ME; McKenna, JE; Melzack, R | 1 |
| Cohen, SR; Melzack, R | 1 |
| Kanui, TI; Karim, F; Towett, PK | 1 |
| Coderre, TJ; Katz, J; Yashpal, K | 1 |
| Manning, BH; Mayer, DJ | 1 |
| Basbaum, AI; Detweiler, DJ; Rohde, DS | 2 |
| Abbott, FV; Guy, ER | 1 |
| Eisenberg, E; Strassman, AM; Vos, BP | 1 |
| Keana, JF; Kwon, IS; Lutfy, K; Marek, P; Sadowski, B; Weber, E | 1 |
| Grouhel, A; Wettstein, JG | 1 |
| Abbott, FV; Franklin, KBJ; Hong, Y | 1 |
| Field, MJ; Hunter, JC; Oles, RJ; Singh, L; Woodruff, GN | 1 |
| Jett, MF; Michelson, S | 1 |
| Lariviere, WR; Melzack, R | 1 |
| Lutfy, K; Shen, KZ; Weber, E; Woodward, RM | 1 |
| Abbott, FV; Franklin, KBJ; Melzack, R | 1 |
| Kishimoto, Y; Misawa, M; Suzuki, T | 1 |
| Cadet, R; Duale, C; Luccarini, P; Woda, A | 1 |
| Chaplan, SR; Malmberg, AB; Yaksh, TL | 1 |
| Ottani, A; Pini, LA; Sandrini, M; Vitale, G | 1 |
| Coderre, TJ; Sufka, KJ; Watson, GS | 1 |
| Nores, WL; Olson, RD; Soignier, RD; Vaccarino, AL | 1 |
| Cingolani, M; Froldi, R; Saligari, E | 1 |
| Czuczwar, SJ; Dzieciuch, JA; Kleinrok, Z; Przesmycki, K | 1 |
| Cao, XD; Wu, GC; Xu, SF; Zhu, CB | 1 |
| Nozaki-Taguchi, N; Yamamoto, T | 1 |
| Belmonte, C; Cervero, F; De Felipe, C; Doyle, CA; Herrero, JF; Hunt, SP; Laird, JM; O'Brien, JA; Palmer, JA; Smith, AJ | 1 |
| Ferreira, SH; Gomes Lopes, LD; Granados-Soto, V; Rufino, MO | 1 |
| Arneric, SP; Arnold, WH; Bannon, AW; Buckley, MJ; Curzon, P; Decker, MW; Holladay, MW; Kim, DJ; Lin, NH; Lynch, JK; Radek, RJ; Wasicak, JT; Williams, M | 1 |
| Fraioli, S; Nencini, P; Nucerito, CV; Pascucci, T | 1 |
| Franklin, KB; Manning, BH | 1 |
| Takeshita, N; Yamaguchi, I | 1 |
| De Freitas, GA; Santos, AR; Vedana, EM | 1 |
| Manning, BH | 1 |
| Kishimoto, Y; Misawa, M; Nagase, H; Suzuki, T; Takeda, F | 1 |
| Khanna, S; Zheng, F | 1 |
| Imamura, Y; Ishikawa, T; Nakanishi, O | 1 |
| Parvini, S; Pirali, M; Rezayat, M; Tabarrai, E; Zarrindast, MR | 1 |
| Calixto, JB; Miguel, OG; Santos, AR; Yunes, RA | 1 |
| Baamonde, C; Dierssen, M; Flórez, J; Lumbreras, MA; Martínez-Cué, C; Vallina, IF | 1 |
| Alfaro, MJ; Goicoechea, C; Martín, MI; Porras, E | 1 |
| Fernández, MA; García, MD; Sáenz, MT; Tornos, MP | 1 |
| Chung, KM; Huh, SO; Kim, YH; Song, DK; Suh, HW | 1 |
| Bowersox, SS; Gao, D; Pettus, M; Phillips, C; Wang, YX | 1 |
| Banach, M; Przewlocka, B; Przewlocki, R; Serednicki, W; Siedlar, M; Szczepanik, AM; Turchan, J; Wordliczek, J; Zembala, M | 1 |
| Colin, F; Lebrun, P; Manil, J | 1 |
| Bardin, L; Kim, JA; Siegel, S | 1 |
| Nishiyama, T | 1 |
| Aguirre-Bañuelos, P; Granados-Soto, V; Mixcoatl-Zecuatl, T | 1 |
| Abdollahi, M; Habibi, L; Nikfar, S | 1 |
| Alloui, A; Eschalier, A; Jourdan, D | 1 |
| Aguirre-Bañuelos, P; Granados-Soto, V | 1 |
| Sahebgharani, M; Shaverdian, S; Zarrindast, MR | 1 |
| Hassanpour, M; Nayebi, AR; Rezazadeh, H | 1 |
| Changeux, JP; Damaj, MI; Epping-Jordan, MP; Marubio, LM; Merlo-Pich, E; Salmon, AM | 1 |
| Almeida, CE; Barcellos, IB; Bonacorso, HG; de Bastiani, J; de Mello, CF; de Oliveira, MR; de Souza, FR; Fighera, MR; Flores, AE; Lima, TT | 1 |
| Li, HD; Li, XC; Ruan, HZ; Wang, J; Wu, X | 1 |
| Anand, KJ; Bhutta, AT; Gossett, JM; Rovnaghi, C; Scalzo, FM; Simpson, PM | 1 |
| Fang, L; Kawase, M; Morimoto, Y; Ohmori, S; Saito, S | 1 |
| Clark, JD; Li, X | 1 |
| Benavides, J; Fournié-Zaluski, MC; Nieto, MM; Noble, F; Roques, BP; Walker, J; Wilson, J | 1 |
| Bu, J; Huang, Z; Shen, M; Xiang, P | 1 |
| Demírezer, LO; Kuruüzüm-Uz, A; Süleyman, H | 1 |
| Dougherty, PM; Grabow, TS | 1 |
| Lutz, EA; Shannon, HE | 1 |
| Begon, S; Dubray, C; Eschalier, A; Pickering, G | 1 |
| Chidiac, JJ; Hawwa, NN; Jabbur, SJ; Jurjus, AR; Massaad, CA; Rifai, K; Saadé, NE | 1 |
| Castañeda-Hernández, G; Granados-Soto, V; Ortiz, MI; Rosas, R; Torres-López, JE; Vidal-Cantú, GC | 1 |
| Mahmoudi, M; Zarrindast, MR | 1 |
| Cao, JL; Duan, SM; Zeng, YM; Zhang, LC | 1 |
| Calixto, JB; Cechinel-Filho, V; Ferreira, J; Malheiros, A; Santos, AR; Scheidt, C; Yunes, RA | 1 |
| Nakama-Kitamura, M | 1 |
| Calixto, JB; Ferreira, J; Santos, AR; Trentin, AP; Yunes, RA | 1 |
| Geisslinger, G; Niederberger, E; Rothstein, JD; Schmidtko, A; Tegeder, I | 1 |
| Bespalov, A; Danysz, W; Sevostianova, N; Zvartau, E | 1 |
| McKenzie, E; Tomanek, B; Tuor, UI | 1 |
| Kanjanapothi, D; Panthong, A; Taesotikul, T; Trongsakul, S | 1 |
| Ando, K; Harada, E; Hayashida, K; Shimizu, H; Takeuchi, T | 1 |
| Chocyk, A; Labuz, D; Przewlocka, B; Toth, G; Wedzony, K | 1 |
| Duan, SH; Fei, J; Guo, LH; Hu, JH; Jiang, J; Ma, YH; Mei, ZT; Yang, N; Zhou, XG | 1 |
| SCHENKER, S; WARREN, KS | 1 |
| Ando, R; Okuda, K; Sakurada, C; Sakurada, S; Sakurada, T; Watanabe, C | 1 |
| Aoki, KR; Cui, M; Khanijou, S; Rubino, J | 1 |
| JACOB, J; SZERB, J | 1 |
| Beckett, SR; Chapman, V; Finn, DP; Fone, KC; Kendall, DA; Madjd, A; Marsden, CA; Roe, CH | 1 |
| Jhamandas, K; McNaull, B; Quirion, R; Trang, T | 1 |
| Dallel, R; Dégoulange, C; Gaydier, AM; Luccarini, P; Perrier, L | 1 |
| Ise, Y; Kishimoto, Y; Misawa, K; Narita, M; Suzuki, T; Yajima, Y | 1 |
| Eti, Z; Gerçek, A; Göğüş, FY; Sav, A | 1 |
| Al-Khrasani, M; Friedmann, T; Fürst, S; Makuch, W; Obara, I; Przewlocka, B; Przewlocki, R; Riba, P; Schmidhammer, H; Schütz, J; Spetea, M; Tímar, J | 1 |
| Davis, AM; Inturrisi, CE; Monaghan, DT; Shimoyama, M; Shimoyama, N | 1 |
| Hong, Y; Huang, H; Zeng, X | 1 |
| Chen, JQ; Dai, J; Liang, SP; Luo, ZM; Zhang, YQ | 1 |
| Huo, FQ; Jia, H; Tang, JS; Wang, J; Xie, YF | 1 |
| Coelho, LP; Coelho, MG; da Costa e Silva, MC; da Silva Lopes, C; de Carvalho Sabino, KC; de Castro, FL; Gayer, CR; Reis, PA; Todeschini, AR | 1 |
| Chapman, V; Haynes, L; Marsden, CA; Morris, PG; Prior, MJ; Shah, YB | 1 |
| Cai, J; Guo, QL; Wang, E; Zou, WY | 1 |
| Aliaga, M; Besson, JM; Buritova, J; Colpaert, F; Larrue, S | 1 |
| Baeyens, JM; Cendán, CM; Portillo-Salido, E; Pujalte, JM | 1 |
| Lane, DA; Morgan, MM; Patel, PA | 1 |
| Andrade, Ada S; de Castro, M; Gameiro, GH; Pereira, LF; Tambeli, CH; Veiga, MC | 1 |
| Alagheband, P; Fazli-Tabaei, S; Rastegar, F; Safari, S; Samie, HR; Yahyavi, SH; Zarrindast, MR | 1 |
| Bae, HB; Choi, Jl; Chung, SS; Chung, ST; Jeong, CY; Jeong, SW; Kim, SJ; Yoo, KY; Yoon, MH | 1 |
| Bespalov, AY; Danysz, W; Sevostianova, N | 1 |
| Bae, HB; Choi, JI; Chung, ST; Kim, CM; Kim, SJ; Yoon, MH | 2 |
| Askalany, AR; Baba, H; Kohno, T; Petrenko, AB; Sakimura, K; Yamakura, T | 1 |
| Kendig, JJ; Sweitzer, SM; Zhang, G; Zissen, MH | 1 |
| Fossum, EN; King, MM; Morgan, MM; Stalding, BM | 1 |
| Beaulieu, P; Guindon, J; Lu, S; Marcil, J; Ngoc, AH; Walczak, JS | 1 |
| Basler, A; Hama, A; Sagen, J | 1 |
| Danysz, W; Sevostianova, N | 1 |
| Cruz-Vera, J; Diaz-Zagoya, JC; Flores-Murrieta, FJ; Granados-Soto, V; Juárez-Rojop, IE; Ortíz-López, JU; Torres-López, JE | 1 |
| Childeric, A; Dallel, R; Gaydier, AM; Luccarini, P; Voisin, D | 1 |
| Furlong, EB; Muccillo-Baisch, AL; Parker, AG; Peraza, GG; Sena, J; Silva, ES; Soares, MC; Vaz, MR | 1 |
| Kimura, M; Komiyama, N; Morita, Y; Okura, T; Yamada, S | 1 |
| Asgari-Afshar, A; Sahebgharani, M; Zarrindast, MR | 1 |
| Avila-Peña, D; Peña, N; Quintero, L; Suárez-Roca, H | 1 |
| Dallel, R; Dualé, C; Sierralta, F | 1 |
| Hamabe, W; Mashida, E; Nagae, R; Tokuyama, S | 1 |
| Andrade, EL; Calixto, JB; Ferreira, J; Santos, AR | 1 |
| Furuta, A; Sakiyama, Y; Sujaku, T | 1 |
| García Bermejo, LF; Murillo Pulgarín, JA; Sánchez García, MN | 1 |
| Boyette-Davis, JA; Fuchs, PN; Thompson, CD | 1 |
| Chen, YF; Li, N; Qin, LP; Rahman, K; Wu, JZ; Zhang, H; Zhang, QY; Zheng, HC | 1 |
| Cechinel Filho, V; de Souza, MM; Delle Monache, F; Delle Monache, G; Fischer, LG; Malheiros, A; Santos, D; Serafin, C | 1 |
| Hanato, J; Hatanaka, J; Hirai, K; Uchida, S; Umegaki, K; Yamada, S | 1 |
| Choi, HW; Jang, JE; Jung, JS; Kwon, MS; Lee, JK; Park, SH; Seo, YJ; Suh, HW | 1 |
| García Bermejo, LF; Lemus Gallego, JM; Murillo Pulgarín, JA; Sánchez García, MN | 1 |
| Alexandre-Moreira, MS; Barreiro, EJ; Bolzani, Vda S; de Miranda, AL; Fraga, CA; Viegas, C | 1 |
| Arai, Y; Furuta, S; Kotlinska, J; Nakagawasai, O; Niijima, F; Sato, T; Satoh, S; Shimoda, M; Silberring, J; Sugawara, M; Tadano, T; Tan-No, K; Terenius, L; Watanabe, H | 1 |
| Benedito, RB; de Almeida, RN; de Araújo, DA; de Sousa, DP; Gonçalves, JC; Oliveira, Fde S | 1 |
| Mahmoudi, M; Mojra, E; Morteza-Semnani, K | 1 |
| Crooks, PA; Holtman, JR; Johnson-Hardy, J; Wala, EP | 1 |
| Chang, C; Chen, JC; Chen, YY; Chiang, YC; Huang, CH; Jaw, FS; Liu, RS; Shih, YY | 1 |
| Kumar, GH; Mat Jais, AM; Somchit, MN; Sulaiman, MR; Zakaria, ZA | 1 |
| Christianson, CA; Hua, XY; Nazarian, A; Yaksh, TL | 1 |
| An, TH; Hua, CJ; Huang, LJ; Kim, WM; Kim, YO; Lee, HG; Park, KD; Yoon, MH | 1 |
| Kaminska, D; Korostynski, M; Makuch, W; Obara, I; Parkitna, JR; Przewlocka, B; Przewlocki, R | 1 |
| Hernández, L; Páez, X; Quiñones, B; Silva, E | 1 |
| Sakande, J; Soro, TY; Traore, F | 1 |
| Burgos, E; Goicoechea, C; Martín, MI; Pascual, D | 1 |
| Chen, YF; Huang, Y; Qin, LP; Tang, WZ; Zheng, HC | 1 |
| Abe, T; Kobayashi, M; Satoh, F; Sugiyo, S; Takemura, M; Uehashi, D; Yonehara, N | 1 |
| Chereshnev, I; Criesta, M; Kolesnikov, YA; Pan, YX; Pasternak, GW | 1 |
| Amaral, JF; Araújo, FL; Barbosa-Filho, JM; de Sousa, FC; Gutierrez, SJ; Leite, CP; Melo, CT; Moura, BA; Rocha, NF; Vasconcelos, SM; Viana, GS | 1 |
| Haghparast, A; Khani, A; Lashgari, R; Motamedi, F; Naderi, N | 1 |
| Ambriz-Tututi, M; Araiza-Saldaña, CI; Caram-Salas, NL; Castañeda-Corral, G; Cruz, SL; Granados-Soto, V; Rocha-González, HI | 1 |
| Amirabadi, A; Azimzadeh, BS; Eskandarizadeh, A; Foroumadi, A; Heidari, MR; Samzadeh-Kermani, A | 1 |
| Bajic, D; Commons, KG | 1 |
| Hashemi, M; Karami, M; Sahebgharani, M; Zarrindast, MR | 1 |
| Barros, DM; de Castro, MR; de Souza, MM; Dickel, OE; Guterres, L; Henriques, AT; Ramirez, MR | 1 |
| Almeida, FR; Chaves, MH; Costa, DA; Figueiredo, KA; Lopes, LS; Marques, RB; Pereira, SS | 1 |
| Dong, HJ; Gong, ZH; Huang, PT; Liu, YL; Su, RB; Yan, LD; Zhang, L; Zhou, PL | 1 |
| Benevides, NM; Holanda, ML; Lima, ME; Lima, V; Pinheiro, PG; Rodrigues, JA; Silva, LM | 1 |
| Hashim, P; Israf, DA; Khalid, S; Mohamad, AS; Rejab, S; Shaberi, AM; Shaik Mossadeq, WM; Sulaiman, MR; Zakaria, ZA | 1 |
| Fujita-Hamabe, W; Harada, S; Nagae, R; Nakamoto, K; Nawa, A; Tokuyama, S | 1 |
| Almeida, JR; Araujo, AA; Araújo, DA; Bonjardim, LR; De Sousa, DP; Gelain, DP; Gonçalves, JC; Melo, MS; Onofre, AC; Quintans-Júnior, LJ | 1 |
| Aloisi, AM; Anzini, M; Cappelli, A; Ceccarelli, I; Danielli, B; Fiorenzani, P; Giordano, A; Maddalena, M; Rossi, A; Rovini, M; Sorda, G; Tomei, V | 1 |
| Adachi, LS; Bonan, CD; Caumo, W; de Souza, A; Espinosa, J; Medeiros, LF; Neto, AS; Rozisky, JR; Torres, IL | 1 |
| Ahmadiani, A; Amini, H; Moradi-Azani, M | 1 |
| Couto, VM; Dias, DF; Dos Santos, MH; Giusti-Paiva, A; Nascimento, CG; Soncini, R; Vilela, FC | 1 |
| Reid, AR; Sawynok, J | 1 |
| Choi, JI; Kim, CM; Kim, KS; Kim, WM; Kim, YO; Lee, HG; Yoon, MH | 1 |
| Bornhof, M; Ihmsen, H; Schwilden, H; Tzabazis, A; Yeomans, DC | 1 |
| Erfanparast, A; Farshid, AA; Khalilzadeh, E; Tamaddonfard, E | 1 |
| Alexandre-Moreira, MS; Alves, MA; Barreiro, EJ; Beraldo, H; Castellano, EE; Júnior, WB; Lima, LM; Parrilha, GL; Perez-Rebolledo, A; Piro, OE | 1 |
| Dyhr, H; Erichsen, HK; Hansen, MK; Marcher, L; Munro, G; Sheykhzade, M; Storm, A | 1 |
| Bum, EN; Dawe, A; De Waard, M; Dimo, T; Dzeufiet, PD; Nguimbou, RM; Sidiki, N; Taïwe, GS; Talla, E | 1 |
| Fukazawa, Y; Iwai, S; Kiguchi, N; Kishioka, S; Kobayashi, Y; Saika, F; Ueno, K; Yamamoto, C | 1 |
| Jin, HB; Li, YR; Song, YL; Yang, YB; Yang, YL | 1 |
| Bendix, I; Boos, V; Dührsen, L; Dzietko, M; Felderhoff-Mueser, U; Genz, K; Sifringer, M; Simons, SH; Tibboel, D | 1 |
| Austin, JS; Khoutorsky, A; Labialle, S; LaCroix-Fralish, ML; Melmed, K; Mogil, JS; Naumova, AK; Schmidt, JV; Sorge, RE; Sotocinal, SG; Tuttle, AH; Wood, JN | 1 |
| Miranda, HF; Noriega, V; Prieto, JC; Sierralta, F; Zepeda, RJ | 1 |
| Carmona-Díaz, E; Cortés-Peñaloza, JL; Guzmán-Priego, CG; Rocha-González, HI; Torres-López, JE | 1 |
| Aonuma, H; Kasukawa, Y; Miyakoshi, N; Segawa, T; Shimada, Y; Tsuchie, H | 1 |
| Bhattacharya, SK; Gupta, LK; Gupta, R | 1 |
| Martin, WJ; Obedencio, GP; Shen, F; Smith, JA; Tsuruda, PR | 1 |
| Alves, PB; Araújo, AA; Bonjardim, LR; de Lucca Júnior, W; Lucchese, AM; Menezes, PP; Quintans, JS; Quintans-Júnior, LJ; Santos, MR; Siqueira-Lima, PS | 1 |
| Cai, GJ; Chen, YF; Liu, DH; Wang, XW; Wu, Q; Yang, C; Yang, Y; Zhang, JY | 1 |
| Bastian, G; Bourgoin, S; Hamon, M; Kayser, V; Michot, B | 1 |
| Beaulieu, P; Bouchard, JF; Desroches, J; Gendron, L | 1 |
| Abe, T; Kuki, F; Niwa, H; Sugiyo, S; Takemura, M | 1 |
| Carlezon, WA; Cheng, K; Leitl, MD; Negus, SS; Potter, DN; Rice, KC | 1 |
| Farshid, AA; Tamaddonfard, E; Yousofizadeh, S | 1 |
| Guindon, J; Hohmann, AG; Hughes, A; Mackie, K; Marcus, DJ; Morgan, DJ; Yuill, MB; Zee, M | 1 |
| Dabaghi, M; Erfanparast, A; Taati, M; Tamaddonfard, E | 1 |
| Leitl, MD; Negus, SS | 1 |
| Khoshdel, Z; Owji, AA; Takhshid, MA | 1 |
| Chen, Y; Huang, Q; Li, XY; Sun, ML; Wang, YX | 1 |
| Armendariz, A; Harton, LR; Nazarian, A; Richardson, JR | 1 |
| Avila-Rojas, SH; Barragán-Iglesias, P; Granados-Soto, V; Pineda-Farias, JB; Salinas-Abarca, AB | 1 |
| Braga, RM; de Almeida, RN; de Castro, RD; de Sousa, DP; de Sousa, FB; deM Pordeus, LC; Tomaz-Morais, JF | 1 |
| Abdollahzadeh, M; Golmakani, E; Hashemzaei, M; Iranshahi, M; Rezaee, R; Tabrizian, K | 1 |
| Abreu, ÂO; Batista, FLA; Campos, AR; de Oliveira, MV; de Sousa, CÁPB; Magalhães, FEA; Menezes, RB; Moura, LFWG; Raposo, RDS; Santos, SAAR | 1 |
| Alhadeff, AL; Betley, JN; De Jonghe, BC; Guo, C; Hantman, AW; Hernandez, E; Holland, RA; Klima, ML; Phillips, SZ; Su, Z | 1 |
| Adler, MW; Chen, X; Cowan, A; Eisenstein, TK; Geller, EB; Inan, S; Meissler, JJ; Rawls, SM; Tallarida, CS; Tallarida, RJ; Watson, MN | 1 |
| Chen, D; Fang, Q; Li, N; Niu, J; Xiao, J; Xu, B; Xu, K; Zhang, M; Zhang, Q; Zhang, R; Zhao, G; Zhu, H | 1 |
| Ashabi, G; Hoseini, M; Karimiyan, SM; Mehrabadi, S; Moradbeygi, K | 1 |
| Agra Cavalcante Silva, LH; Alves de Lima, L; Caldas da Silva Dantas Viegas, C; Felício de Sousa Santos, AK; Leite Ferreira, MD; Marinho Braga, R; Nobrega de Almeida, R; Nunes de Andrade, HH; Ribeiro, MD; Sérgio Silva, A; Simões de Assis Cantalice, T; Vanderlei de Souza, MF | 1 |
| Azizi, H; Khalouzadeh, F; Semnanian, S | 1 |
| Bahadori, R; Dolatyarieslami, M; Khalilzadeh, E; Khanna, R; Mousavi, S | 1 |
| Benito, N; Ezquieta, B; Gamallo, C; Limeres, MA; Molano, J; Palacios, J; Rodriguez, JI | 1 |
1 review(s) available for formaldehyde and morphine
| Article | Year |
|---|---|
The use of amine fluorescence histochemistry in the study of drugs, especially morphine on the CNS.
Topics: Amines; Animals; Catecholamines; Central Nervous System; Fluorescence; Fluorometry; Formaldehyde; Histocytochemistry; Male; Microchemistry; Models, Theoretical; Morphine; Nerve Endings; Neurons; Rats | 1975 |
3 trial(s) available for formaldehyde and morphine
| Article | Year |
|---|---|
The effect of pentoxifiline on post-injury hyperalgesia in rats and postoperative pain in patients.
Topics: Adult; Animals; Cholecystectomy; Formaldehyde; Humans; Hyperalgesia; Injections, Intraperitoneal; Injections, Intravenous; Injections, Spinal; Interleukin-6; Male; Meperidine; Middle Aged; Morphine; Pain; Pain Measurement; Pain Threshold; Pain, Postoperative; Pentoxifylline; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2000 |
Orofacial antinociceptive activity of (S)-(-)-perillyl alcohol in mice: a randomized, controlled and triple-blind study.
Topics: Animals; Capsaicin; Facial Pain; Formaldehyde; Glutamic Acid; Male; Mice; Monoterpenes; Morphine; Pain Measurement | 2017 |
Effect of morphine and ibuprofen on nociceptive behavior, preening and motor activity following tonic chemical pain in the Japanese quail (Coturnix japonica).
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Coturnix; Formaldehyde; Grooming; Ibuprofen; Male; Morphine; Motor Activity; Nociception; Pain | 2022 |
292 other study(ies) available for formaldehyde and morphine
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Serum corticosterone as a quantitative test of the phlogistic potency of various agents topically applied in the rat.
Topics: Administration, Topical; Adrenal Glands; Animals; Ascorbic Acid; Corticosterone; Croton Oil; Dexamethasone; Formaldehyde; Hypophysectomy; Inflammation; Liver; Male; Mepivacaine; Morphine; Mustard Plant; Pentobarbital; Plant Extracts; Plants, Medicinal; Rats; Time Factors; Tyrosine Transaminase | 1976 |
Naloxone reversal of morphine analgesia but failure to alter reactivity to pain in the formalin test.
Topics: Analgesia; Animals; Formaldehyde; Male; Morphine; Naloxone; Pain; Rats; Reaction Time; Receptors, Opioid; Time Factors | 1978 |
A test for analgesics as an indicator of locomotor activity in writhing mice.
Topics: Acetates; Aminopyrine; Analgesics; Animals; Drug Interactions; Formaldehyde; Male; Mice; Morphine; Motor Activity; Narcotics; Pain; Time Factors | 1979 |
Hepatic aminopyrine N-demethylase system: further studies of assay procedure.
Topics: Aminopyrine; Animals; Cytochrome P-450 Enzyme System; Formaldehyde; Liver; Male; Methods; Microsomes, Liver; Morphine; Oxidoreductases, N-Demethylating; Rats; Semicarbazides; Time Factors | 1977 |
The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats.
Topics: Animals; Behavior, Animal; Brain Stem; Cats; Drug Evaluation; Forelimb; Formaldehyde; Injections, Subcutaneous; Meperidine; Morphine; Pain; Raphe Nuclei; Rats; Species Specificity; Time Factors | 1977 |
Formaldehyde interference with fluorescence determination of morphine in urine.
Topics: Chromatography, Thin Layer; False Negative Reactions; Fluorometry; Formaldehyde; Humans; Morphine | 1978 |
NMDA receptor antagonist MK-801 blocks non-opioid stress-induced analgesia in the formalin test.
Topics: Analgesia; Animals; Dizocilpine Maleate; Formaldehyde; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Pain; Receptors, N-Methyl-D-Aspartate; Sensation; Stress, Physiological | 1992 |
Intrathecal midazolam versus intrathecal morphine in orofacial nociception: an experimental study in rats.
Topics: Animals; Facial Pain; Formaldehyde; Injections, Spinal; Male; Midazolam; Morphine; Mouth; Nociceptors; Pain; Rats; Rats, Sprague-Dawley | 1992 |
Differential antinociceptive effects of morphine and methylmorphine in the formalin test.
Topics: Analgesics; Animals; Codeine; Dose-Response Relationship, Drug; Formaldehyde; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Morphine; Narcotic Antagonists; Oxymorphone; Pain; Pain Measurement | 1992 |
Formalin pain is expressed in decerebrate rats but not attenuated by morphine.
Topics: Animals; Behavior, Animal; Brain Stem; Decerebrate State; Formaldehyde; Morphine; Muscle Tonus; Pain; Rats; Reaction Time | 1992 |
Infusions of 6-hydroxydopamine into the nucleus accumbens abolish the analgesic effect of amphetamine but not of morphine in the formalin test.
Topics: Analgesics; Animals; Dextroamphetamine; Dopamine; Formaldehyde; Hydroxydopamines; Infusions, Parenteral; Male; Morphine; Motor Activity; Nucleus Accumbens; Pain; Rats | 1992 |
Dopamine receptor subtypes and formalin test analgesia.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analgesia; Animals; Apomorphine; Benzazepines; Dextroamphetamine; Dopamine Agents; Dopamine Antagonists; Dose-Response Relationship, Drug; Ergolines; Flupenthixol; Formaldehyde; Male; Morphine; Pain; Pimozide; Quinpirole; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1991 |
Systemic morphine suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord.
Topics: Animals; Dose-Response Relationship, Drug; Formaldehyde; Immunologic Techniques; Male; Morphine; Pain; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains; Spinal Cord; Staining and Labeling; Time Factors; Tissue Distribution | 1990 |
Morphine does not reduce the intraspinal release of calcitonin gene-related peptide in the cat.
Topics: Animals; Calcitonin Gene-Related Peptide; Cats; Electric Stimulation; Formaldehyde; Immunohistochemistry; Iodine Radioisotopes; Morphine; Nociceptors; Polymers; Spinal Cord; Staining and Labeling | 1990 |
Pharmacological studies on lappaconitine: antinociception and inhibition of the spinal action of substance P and somatostatin.
Topics: Aconitine; Analgesics; Animals; Behavior, Animal; Brain; Cysteamine; Diclofenac; Formaldehyde; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Morphine; Neurons; Nociceptors; Somatostatin; Spinal Cord; Substance P | 1991 |
Systemic capsaicin and olvanil reduce the acute algogenic and the late inflammatory phase following formalin injection into rodent paw.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Electrophysiology; Foot; Formaldehyde; Indomethacin; Inflammation; Mice; Morphine; Neurons; Pain; Spinal Cord | 1991 |
Hyperbaric exposure and morphine alter the pattern of behavior in the formalin test.
Topics: Air Pressure; Animals; Atmosphere Exposure Chambers; Behavior, Animal; Dose-Response Relationship, Drug; Formaldehyde; Male; Morphine; Motor Activity; Pain; Rats; Rats, Inbred Strains | 1991 |
Standardization of the rat paw formalin test for the evaluation of analgesics.
Topics: Analgesics; Animals; Aspirin; Behavior, Animal; Decerebrate State; Foot; Formaldehyde; Male; Morphine; Pain; Pyrroles; Rats; Rats, Inbred Strains; Reference Standards; Thiophenes | 1991 |
beta-Funaltrexamine antagonizes the analgesic effects of mu and kappa agonists in the formalin test.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dose-Response Relationship, Drug; Ethylketocyclazocine; Formaldehyde; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Urination | 1990 |
Morphine decreases cerebral glucose utilization in limbic and forebrain regions while pain has no effect.
Topics: Animals; Autoradiography; Blood Gas Analysis; Blood Pressure; Brain Chemistry; Deoxyglucose; Dose-Response Relationship, Drug; Formaldehyde; Glucose; Limbic System; Male; Morphine; Pain; Rats; Rats, Inbred F344 | 1991 |
The antinociceptive effects of anterior pretectal stimulation in tests using thermal, mechanical and chemical noxious stimuli.
Topics: Animals; Brain; Formaldehyde; Hot Temperature; Injections, Subcutaneous; Male; Morphine; Nociceptors; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Inbred Strains; Reaction Time; Reflex; Stereotaxic Techniques; Stimulation, Chemical; Superior Colliculi | 1991 |
Morphine hyperalgesic effects on the formalin test in domestic fowl (Gallus gallus).
Topics: Animals; Behavior, Animal; Chickens; Conditioning, Operant; Formaldehyde; Male; Morphine; Naloxone; Nociceptors; Pain; Pain Measurement; Reaction Time; Respiration | 1991 |
6-Hydroxydopamine lesions of the ventral tegmentum abolish D-amphetamine and morphine analgesia in the formalin test but not in the tail flick test.
Topics: Analgesia; Animals; Corpus Striatum; Dextroamphetamine; Dopamine; Formaldehyde; Hydroxydopamines; Male; Morphine; Oxidopamine; Pain; Rats; Substantia Nigra | 1990 |
Tonic nociception in neonatal rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Dose-Response Relationship, Drug; Female; Formaldehyde; Male; Morphine; Nociceptors; Pain; Stereotyped Behavior | 1990 |
Further studies of the effects of intranigral morphine on behavioral responses to noxious stimuli.
Topics: Animals; Formaldehyde; Male; Mesencephalon; Microinjections; Morphine; Pain; Periaqueductal Gray; Psychomotor Performance; Rats; Rats, Inbred Strains; Reticular Formation; Substantia Nigra; Tegmentum Mesencephali | 1990 |
The formalin test in mice: effect of formalin concentration.
Topics: Analgesics; Animals; Aspirin; Forelimb; Formaldehyde; Indomethacin; Male; Mice; Mice, Inbred Strains; Morphine; Nociceptors; Osmolar Concentration | 1990 |
Diazepam attenuates morphine antinociception test-dependently in mice.
Topics: Analgesics; Animals; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Morphine; Pain; Pain Measurement; Psychomotor Performance; Reaction Time; Skin Temperature | 1990 |
Effect of 5-hydroxytryptamine precursors on morphine analgesia in the formalin test.
Topics: 5-Hydroxytryptophan; Analgesia; Animals; Behavior, Animal; Central Nervous System; Dose-Response Relationship, Drug; Drug Synergism; Formaldehyde; Hydroxyindoleacetic Acid; Male; Morphine; Pain Measurement; Rats; Serotonin; Tryptophan | 1988 |
Naloxone blocks the formalin-induced increase of substance P in the dorsal horn.
Topics: Animals; Female; Formaldehyde; Immunoenzyme Techniques; Morphine; Naloxone; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1989 |
Modified formalin test: characteristic biphasic pain response.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Bromelains; Capsaicin; Dexamethasone; Dose-Response Relationship, Drug; Formaldehyde; Indomethacin; Male; Mice; Morphine; Nerve Fibers; p-Methoxy-N-methylphenethylamine; Pain; Pain Measurement; Sciatic Nerve; Substance P; Time Factors | 1989 |
Noradrenergic and opioidergic influences on the antinociceptive effect of clomipramine in the formalin test in rats.
Topics: Analgesics; Animals; Clomipramine; Endorphins; Female; Formaldehyde; Morphine; Naloxone; Norepinephrine; Pain Measurement; Phentolamine; Prazosin; Rats; Rats, Inbred Strains; Yohimbine | 1989 |
Comparison of PD 117302, a kappa agonist, and morphine on colonic transit and formalin-induced pain in rats.
Topics: Animals; Colon; Dose-Response Relationship, Drug; Formaldehyde; Gastrointestinal Transit; Male; Morphine; Pain; Pyrroles; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Thiophenes | 1989 |
Use of the formalin test in evaluating analgesics.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Butorphanol; Dose-Response Relationship, Drug; Formaldehyde; Male; Morphine; Nalbuphine; Nociceptors; Pain; Pentazocine; Rats; Rats, Inbred Strains; Sensory Thresholds | 1989 |
Analgesic action of clonixin, nifedipine and morphine using the formalin test.
Topics: Analgesics; Animals; Clonixin; Drug Tolerance; Female; Formaldehyde; Lethal Dose 50; Male; Mice; Morphine; Nicotinic Acids; Nifedipine; Pain Measurement; Rats | 1989 |
Application of the formalin test to the study of orofacial pain in the rat.
Topics: Acetaminophen; Animals; Aspirin; Facial Pain; Formaldehyde; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Rats; Rats, Inbred Strains; Time Factors | 1989 |
Participation of the nucleus reticularis gigantocellularis in the morphine-induced elevation of plasma corticosterone in rats.
Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Dose-Response Relationship, Drug; Formaldehyde; Male; Medulla Oblongata; Morphine; Rats; Rats, Inbred Strains | 1985 |
Methodological refinements to the mouse paw formalin test. An animal model of tonic pain.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Morphine; Nociceptors; Pain; Pentazocine; Time Factors | 1988 |
Modification of the antinociceptive effect of morphine by acute and chronic administration of clomipramine in mice.
Topics: Animals; Body Temperature; Clomipramine; Drug Synergism; Formaldehyde; Male; Mice; Mice, Inbred Strains; Morphine; Nociceptors; Pain Measurement; Time Factors | 1988 |
Effects of morphine on two types of nucleus raphe dorsalis neurons in awake cats.
Topics: Action Potentials; Animals; Cats; Formaldehyde; Morphine; Naloxone; Neurons; Pain; Raphe Nuclei; Wakefulness | 1987 |
The formalin test in mice: dissociation between inflammatory and non-inflammatory pain.
Topics: Acetaminophen; Analgesics; Animals; Aspirin; Formaldehyde; Male; Mice; Mice, Inbred Strains; Morphine; Nociceptors; Pain | 1987 |
Chronic epidural morphine and preservative-induced injury.
Topics: Costs and Cost Analysis; Economics, Medical; Formaldehyde; Humans; Injections, Epidural; Male; Middle Aged; Morphine; Pain, Intractable; Pancreatic Neoplasms; Pharmaceutic Aids; Phenols; Preservatives, Pharmaceutical; Self Administration; Therapeutic Equivalency | 1987 |
Effect of suicide substrate on the metabolism of steroids and xenobiotics and on cytochrome P-450 apoproteins.
Topics: Aminopyrine; Animals; Apoproteins; Carbon Radioisotopes; Cytochrome P-450 Enzyme System; Dicarbethoxydihydrocollidine; Formaldehyde; Formates; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Morphine; Phenobarbital; Pyridines; Rats; Rats, Inbred Strains; Testosterone | 1986 |
Noncompetitive antagonism of morphine analgesia by diazepam in the formalin test.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Formaldehyde; Male; Morphine; Pain; Rats; Reaction Time; Restraint, Physical | 1986 |
Formalin test in mice, a useful technique for evaluating mild analgesics.
Topics: Acetaminophen; Analgesics; Animals; Aspirin; Behavior, Animal; Formaldehyde; Hindlimb; Male; Mice; Mice, Inbred Strains; Morphine; Reaction Time | 1985 |
Studies on the N-demethylation of morphine and other compounds.
Topics: Animals; Cortisone; Formaldehyde; Glucose-6-Phosphatase; In Vitro Techniques; Levallorphan; Liver; Microsomes; Morphine; Nalorphine; Rats | 1965 |
Sex differences in the effects of abnormal physiological states on the metabolism of drugs by rat liver microsomes.
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Aminopyrine; Aniline Compounds; Animals; Castration; Diabetes Mellitus, Experimental; Epinephrine; Female; Formaldehyde; Hexobarbital; Hypoxia; In Vitro Techniques; Liver; Male; Microsomes; Mixed Function Oxygenases; Morphine; Rats; Sex; Thyroxine; Zoxazolamine | 1965 |
Studies on the acute inflammatory response. I. Involvement of the central nervous system in certain models of inflammation.
Topics: Adrenocorticotropic Hormone; Analgesics; Anilides; Animals; Carrageenan; Central Nervous System; Edema; Formaldehyde; Hindlimb; Inflammation; Insulin; Male; Mice; Morphine; Nalorphine; Phenylbutazone; Procaine; Rats; Sciatic Nerve; Serotonin; Spinal Cord; Sulfonic Acids; Sympatholytics | 1968 |
The effects of some analgesics and neuroleptics upon the reflexive and affective components of the formaldehyde- and bradykinin-induced nociceptive reactions in rats.
Topics: Aminopyrine; Analgesics; Animals; Behavior, Animal; Bradykinin; Chlorpromazine; Dose-Response Relationship, Drug; Emotions; Formaldehyde; Methotrimeprazine; Morphine; Pain; Rats; Rats, Inbred Strains; Reflex | 1974 |
[The Marquis reaction of morphine (author's transl)].
Topics: Chemical Phenomena; Chemistry; Colorimetry; Formaldehyde; Magnetic Resonance Spectroscopy; Morphine; Spectrophotometry, Ultraviolet; Sulfuric Acids | 1973 |
A review of some GLD-FID derivitization techniques found useful in forensic toxicology.
Topics: Acetylation; Amphetamine; Bromides; Chromatography, Gas; Forensic Medicine; Formaldehyde; Glycols; Humans; Methadone; Methylation; Morphine; Oxidation-Reduction; Phenytoin; Toxicology | 1974 |
Induction of drug metabolism. II. Qualitative differences in the microsomal N-demethylating systems stimulated by polycyclic hydrocarbons and by phenobarbital.
Topics: Animals; Benzene Derivatives; Benzopyrenes; Carbon Monoxide; Cyanides; Cytochromes; Depression, Chemical; Female; Formaldehyde; Kinetics; Liver; Male; Methylcholanthrene; Mice; Microsomes; Morphinans; Morphine; Phenobarbital; Proadifen; Rats; Sex Factors; Species Specificity; Stimulation, Chemical; Valerates | 1969 |
The formalin test: a tonic pain model in the primate.
Topics: Animals; Behavior, Animal; Chronic Disease; Disease Models, Animal; Female; Formaldehyde; Hand; Macaca mulatta; Male; Meperidine; Morphine; Pain; Restraint, Physical; Time Factors | 1984 |
[Formalin-induced minor tremor response as an indicator of pain].
Topics: Aminopyrine; Analgesics; Animals; Aspirin; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Formaldehyde; Guinea Pigs; Hydrocortisone; Indomethacin; Levallorphan; Male; Morphine; Pain; Pyridinolcarbamate; Tremor | 1984 |
Single nerve capsaicin: effects on pain and morphine analgesia in the formalin and foot-flick tests.
Topics: Analgesia; Animals; Capsaicin; Formaldehyde; Male; Morphine; Pain; Peripheral Nerves; Rats; Sciatic Nerve; Time Factors | 1984 |
Effects of cholinergic and dopaminergic agents on pain and morphine analgesia measured by three pain tests.
Topics: Animals; Drug Synergism; Formaldehyde; Male; Morphine; Pain; Parasympathomimetics; Rats; Rats, Inbred Strains | 1983 |
Morphine analgesia in tail-flick and formalin pain tests is mediated by different neural systems.
Topics: Animals; Brain Stem; Formaldehyde; Male; Mesencephalon; Morphine; Muridae; Neural Inhibition; Nociceptors; Raphe Nuclei; Spinal Cord | 1982 |
Lack of effect of morphine and noxious stimuli on the MET-enkephalin content in the spinal dorsal horn and nucleus reticularis gigantocellularis of the rat.
Topics: Animals; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Formaldehyde; Hot Temperature; Male; Medulla Oblongata; Morphine; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord | 1982 |
Morphine analgesia and tolerance in the tail-flick and formalin tests: dose-response relationships.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Formaldehyde; Morphine; Muridae; Nociceptors; Sensory Thresholds | 1982 |
Apparent lack of tolerance in the formalin test suggests different mechanisms for morphine analgesia in different types of pain.
Topics: Animals; Behavior, Animal; Drug Tolerance; Formaldehyde; Grooming; Morphine; Pain; Rats | 1981 |
The effect of formaldehyde solution in the gas chromatographic determination of morphine.
Topics: Chromatography, Gas; Forensic Medicine; Formaldehyde; Morphine | 1980 |
Examination of tonic nociceptive behavior using a method of substance P-receptor desensitization in the dorsal horn.
Topics: Animals; Formaldehyde; Injections, Spinal; Male; Morphine; Naloxone; Nociceptors; Pain Measurement; Rats; Rats, Wistar; Receptors, Neurokinin-1; Reflex; Spinal Cord; Stereotyped Behavior; Substance P; Uric Acid | 1994 |
Inflammation of the colonic wall induced by formalin as a model of acute visceral pain.
Topics: Acute Disease; Animals; Colitis; Disease Models, Animal; Female; Formaldehyde; Morphine; Naloxone; Pain; Pain Measurement; Palliative Care; Rats; Rats, Sprague-Dawley; Sodium Chloride; Viscera | 1994 |
The formalin-induced expression of tachykinin peptide and neurokinin receptor messenger RNAs in rat sensory ganglia and spinal cord is modulated by opiate preadministration.
Topics: Animals; Formaldehyde; Ganglia, Spinal; Gene Expression Regulation; Male; Morphine; Naltrexone; Neurokinin B; Pain; Premedication; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-3; RNA, Messenger; Spinal Cord; Substance P; Time Factors | 1995 |
Analgesia induced by morphine microinjection into the lateral hypothalamus of the rat.
Topics: Analgesia; Animals; Electric Stimulation; Formaldehyde; Hypothalamus; Male; Microinjections; Morphine; Pain; Rats; Rats, Inbred Strains; Time Factors | 1995 |
Role of GABAergic systems in the development of morphine tolerance in formalin-treated mice.
Topics: Analgesics, Opioid; Animals; Baclofen; Bicuculline; Diazepam; Drug Tolerance; Flumazenil; Formaldehyde; GABA Agonists; GABA Antagonists; Male; Mice; Mice, Inbred Strains; Morphine; Muscimol; Pain; Pain Measurement; Receptors, GABA | 1995 |
Further evidence that substance P is a mediator of both neurogenic inflammation and pain: two phenomena inhibited either by postsynaptic blockade of NK1 receptors or by presynaptic action of opioid receptor agonists.
Topics: Analgesics; Animals; Anticonvulsants; Electric Stimulation; Formaldehyde; Indoles; Inflammation; Isoindoles; Male; Mice; Mice, Inbred Strains; Morphine; Pain; Peripheral Nerves; Pyrroles; Rats; Rats, Sprague-Dawley; Substance P; Thiophenes | 1993 |
Effect of continuous intrathecal infusion of omega-conopeptides, N-type calcium-channel blockers, on behavior and antinociception in the formalin and hot-plate tests in rats.
Topics: Animals; Behavior, Animal; Body Weight; Calcium Channel Blockers; Dose-Response Relationship, Drug; Formaldehyde; Hot Temperature; Injections, Spinal; Morphine; omega-Conotoxins; Peptides; Rats; Rats, Sprague-Dawley | 1995 |
The formalin test: scoring properties of the first and second phases of the pain response in rats.
Topics: Amphetamine; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Formaldehyde; Male; Morphine; Pain; Pain Measurement; Rats; Rats, Wistar | 1995 |
A selective CCKB receptor antagonist potentiates, mu-, but not delta-opioid receptor-mediated antinociception in the formalin test.
Topics: Analgesics; Animals; Disulfides; Enkephalins; Formaldehyde; Indoles; Male; Meglumine; Mice; Morphine; Naloxone; Naltrexone; Pain Measurement; Phenylalanine; Receptors, Cholecystokinin; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
Effects of partial decortication on opioid analgesia in the formalin test.
Topics: Amygdala; Analgesia; Animals; Behavior, Animal; Brain Injuries; Formaldehyde; Morphine; Motor Activity; Narcotics; Nociceptors; Pain; Rats; Tail; Time Factors | 1995 |
Antinociceptive effect of morphine microinjections into the spinal trigeminal subnucleus oralis.
Topics: Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Microinjections; Morphine; Naloxone; Pain; Rats; Rats, Sprague-Dawley; Trigeminal Nucleus, Spinal | 1995 |
The effect of morphine on formalin-evoked behaviour and spinal release of excitatory amino acids and prostaglandin E2 using microdialysis in conscious rats.
Topics: Animals; Behavior, Animal; Citrulline; Dinoprostone; Excitatory Amino Acids; Formaldehyde; Male; Microdialysis; Morphine; Motor Activity; Naloxone; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord | 1995 |
Changes in hypothalamic met-enkephalin levels of rats induced by painful stimulation and morphine treatment.
Topics: Animals; Enkephalin, Methionine; Formaldehyde; Hypothalamus; Male; Morphine; Naloxone; Pain; Rats; Rats, Wistar; Stimulation, Chemical | 1993 |
Morphine dependence with or without tolerance in formalin-treated mice: further evidence for the dissociation.
Topics: Analgesia; Animals; Anxiety; Disease Models, Animal; Drug Tolerance; Formaldehyde; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Morphine; Morphine Dependence; Naloxone; Pain; Pain Threshold | 1994 |
Descending modulation of central neural plasticity in the formalin pain test.
Topics: Analgesia; Animals; Brain; Electric Stimulation; Formaldehyde; Male; Microinjections; Morphine; Neural Pathways; Neuronal Plasticity; Pain Measurement; Periaqueductal Gray; Rats | 1994 |
Morphine analgesia in the formalin test: evidence for forebrain and midbrain sites of action.
Topics: Animals; Brain Mapping; Catalepsy; Formaldehyde; Male; Mesencephalon; Microinjections; Morphine; Motor Activity; Pain Measurement; Prosencephalon; Rats | 1994 |
Halothane enhances suppression of spinal sensitization by intrathecal morphine in the rat formalin test.
Topics: Animals; Formaldehyde; Halothane; Injections, Spinal; Male; Midazolam; Morphine; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, GABA; Spinal Cord | 1994 |
Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice.
Topics: Animals; Anxiety; Aspirin; Diazepam; Drug Tolerance; Flumazenil; Formaldehyde; Indomethacin; Inflammation; Male; Mice; Morphine; Pain; Pain Threshold; Receptors, GABA-A | 1994 |
Electrophysiologic analysis of preemptive effects of spinal opioids on N-methyl-D-aspartate receptor-mediated events.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Electric Stimulation; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Formaldehyde; Morphine; Narcotics; Nerve Fibers; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1994 |
Differential effects of morphine on noxious stimulus-evoked fos-like immunoreactivity in subpopulations of spinoparabrachial neurons.
Topics: Animals; Behavior, Animal; Fluorescent Dyes; Formaldehyde; Immunohistochemistry; Male; Mesencephalon; Morphine; Neurons; Pain; Pons; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Reticular Formation; Stilbamidines | 1994 |
Systemic opioids do not suppress spinal sensitization after subcutaneous formalin in rats.
Topics: Alfentanil; Animals; Drug Administration Schedule; Formaldehyde; Hot Temperature; Hyperalgesia; Injections, Subcutaneous; Isoflurane; Male; Morphine; Naloxone; Pain; Rats; Rats, Sprague-Dawley; Spine; Time Factors | 1994 |
Rapid development of tolerance to morphine in the formalin test.
Topics: Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Female; Formaldehyde; Infusion Pumps; Injections, Subcutaneous; Mice; Mice, Inbred Strains; Morphine; Nociceptors; Pain Measurement; Time Factors | 1994 |
Pharmacology of the spinal action of ketorolac, morphine, ST-91, U50488H, and L-PIA on the formalin test and an isobolographic analysis of the NSAID interaction.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Agonists; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Clonidine; Drug Combinations; Drug Interactions; Formaldehyde; Ketorolac; Male; Morphine; Motor Activity; Nociceptors; Phenylisopropyladenosine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Tolmetin | 1993 |
Effects of pedunculopontine tegmental nucleus lesions on morphine-induced conditioned place preference and analgesia in the formalin test.
Topics: Acetylcholine; Analgesia; Animals; Conditioning, Operant; Diazepam; Formaldehyde; Male; Mesencephalon; Morphine; Pain Measurement; Parasympathetic Nervous System; Pons; Rats; Rats, Wistar | 1993 |
Morphine, clonidine coadministration in subanalgesic doses: effective control of tonic pain.
Topics: Animals; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Female; Formaldehyde; Injections, Intraperitoneal; Male; Morphine; Pain; Pain Measurement; Rats; Rats, Wistar | 1994 |
Evidence for participation of B1 and B2 kinin receptors in formalin-induced nociceptive response in the mouse.
Topics: Animals; Binding, Competitive; Bradykinin; Bradykinin Receptor Antagonists; Captopril; Edema; Formaldehyde; Male; Mice; Morphine; Nociceptors; Pain Measurement; Receptors, Bradykinin | 1993 |
Development of tolerance to morphine antinociception in mice treated with nociceptive stimulants.
Topics: Acetates; Acetic Acid; Animals; Drug Tolerance; Formaldehyde; Freund's Adjuvant; Hindlimb; Male; Mice; Morphine; Pain; Pain Measurement | 1993 |
Morphine fails to produce tolerance when administered in the presence of formalin pain in rats.
Topics: Animals; Drug Tolerance; Formaldehyde; Male; Morphine; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time | 1993 |
Naloxone causes apparent antinociception and pronociception simultaneously in the rat paw formalin test.
Topics: Animals; Behavior, Animal; Buprenorphine; Dose-Response Relationship, Drug; Formaldehyde; Injections, Subcutaneous; Male; Morphine; Naloxone; Pain; Rats; Rats, Sprague-Dawley | 1993 |
Ketorolac tromethamine: an experimental study of its analgesic effects in the rat.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Combinations; Electromyography; Formaldehyde; Indomethacin; Ketorolac Tromethamine; Morphine; Nociceptors; Pain Measurement; Prostaglandin Antagonists; Quinacrine; Rats; Rats, Wistar; Reflex; Tolmetin; Tromethamine | 1993 |
The formalin test: a validation of the weighted-scores method of behavioural pain rating.
Topics: Animals; Behavior, Animal; Formaldehyde; Male; Models, Biological; Morphine; Pain Measurement; Rats; Regression Analysis | 1993 |
The habenula and pain: repeated electrical stimulation produces prolonged analgesia but lesions have no effect on formalin pain or morphine analgesia.
Topics: Animals; Brain Mapping; Diencephalon; Electric Stimulation; Formaldehyde; Male; Morphine; Neural Pathways; Pain Threshold; Rats; Receptors, Opioid; Thalamic Nuclei | 1993 |
The formalin test in the naked mole-rat (Heterocephalus glaber): analgesic effects of morphine, nefopam and paracetamol.
Topics: Acetaminophen; Analgesics; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Formaldehyde; Morphine; Nefopam; Nociceptors; Pain; Rodentia | 1993 |
Effects of preemptive or postinjury intrathecal local anesthesia on persistent nociceptive responses in rats. Confounding influences of peripheral inflammation and the general anesthetic regimen.
Topics: Analgesia; Anesthesia, Spinal; Anesthetics, Local; Animals; Barbiturates; Formaldehyde; Inflammation; Injections, Spinal; Lidocaine; Male; Morphine; Pain, Postoperative; Rats | 1996 |
The central nucleus of the amygdala contributes to the production of morphine antinociception in the formalin test.
Topics: Amygdala; Analgesics, Opioid; Animals; Brain Mapping; Formaldehyde; Hindlimb; Injections; Male; Morphine; N-Methylaspartate; Nociceptors; Pain Measurement; Rats; Rats, Sprague-Dawley; Time Factors | 1995 |
The development of opioid tolerance in the formalin test in the rat.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Drug Implants; Drug Tolerance; Formaldehyde; Hindlimb; Injections, Subcutaneous; Male; Morphine; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley | 1995 |
Effects of morphine, pentobarbital and amphetamine on formalin-induced behaviours in infant rats: sedation versus specific suppression of pain.
Topics: Amphetamine; Animals; Animals, Newborn; Behavior, Animal; Female; Formaldehyde; Hypnotics and Sedatives; Male; Morphine; Pain; Palliative Care; Pentobarbital; Rats | 1995 |
The peripheral antinociceptive effect of morphine in a rat model of facial pain.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Facial Pain; Formaldehyde; Grooming; Injections, Subcutaneous; Male; Morphine; Naloxone; Narcotic Antagonists; Nociceptors; Rats; Rats, Sprague-Dawley; Vibrissae | 1996 |
Differential sensitivity of mice bred for stress-induced analgesia to morphine and ACEA-1011 in the formalin test.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Narcotic Antagonists; Pain Measurement; Quinoxalines; Stress, Psychological; Swimming | 1996 |
Opioid antagonist profile of SC nor-binaltorphimine in the formalin paw assay.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes | 1996 |
The effect of lesions of the dorsolateral funiculus on formalin pain and morphine analgesia: a dose-response analysis.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Formaldehyde; Hot Temperature; Immersion; Male; Morphine; Pain; Pain Measurement; Rats; Spinal Cord | 1996 |
Modulation of the in vivo actions of morphine by the mixed CCKA/B receptor antagonist PD 142898.
Topics: Animals; Conditioning, Psychological; Formaldehyde; Gastrointestinal Transit; Hormone Antagonists; Indoles; Male; Morphine; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin | 1996 |
The formalin test in rat: validation of an automated system.
Topics: Animals; Behavior, Animal; Biphenyl Compounds; Dose-Response Relationship, Drug; Evaluation Studies as Topic; Foot; Formaldehyde; Male; Morphine; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Signal Processing, Computer-Assisted; Stimulation, Chemical | 1996 |
The bee venom test: a new tonic-pain test.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Aspirin; Bee Venoms; Behavior, Animal; Edema; Foot; Formaldehyde; Injections, Subcutaneous; Male; Morphine; Pain Measurement; Rats | 1996 |
Inhibition of morphine tolerance by NMDA receptor antagonists in the formalin test.
Topics: Animals; Behavior, Animal; Binding, Competitive; Brain Chemistry; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Electrophysiology; Excitatory Amino Acid Antagonists; Female; Formaldehyde; Gene Expression; Locomotion; Male; Mice; Morphine; Motor Activity; Narcotics; Nociceptors; Oocytes; Quinoxalines; Radioligand Assay; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Xenopus laevis | 1996 |
Comments on Detweiler et al. (Pain 63 (1995) 251-254)
Topics: Analgesics; Animals; Drug Implants; Drug Tolerance; Formaldehyde; Morphine; Pain Measurement; Rats | 1996 |
Formalin- and carrageenan-induced inflammation attenuates place preferences produced by morphine, methamphetamine and cocaine.
Topics: Animals; Behavior, Animal; Carrageenan; Cocaine; Conditioning, Operant; Formaldehyde; Indomethacin; Inflammation; Male; Methamphetamine; Morphine; Narcotics; Pain; Rats; Rats, Sprague-Dawley | 1996 |
Effects of morphine microinjections into the trigeminal sensory complex on the formalin test in the rat.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Formaldehyde; Lip; Male; Microinjections; Morphine; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Trigeminal Nucleus, Spinal | 1996 |
Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dextromethorphan; Dextrorphan; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Formaldehyde; Hyperalgesia; Injections, Spinal; Ketamine; Male; Memantine; Morphine; Pain; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Spinal Nerves; Touch | 1997 |
Naloxone-reversible antinociception by paracetamol in the rat.
Topics: Acetaminophen; Animals; Cerebral Cortex; Formaldehyde; Hot Temperature; Ketanserin; Kinetics; Male; Morphine; Motor Activity; Naloxone; Pain; Pons; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Stereotyped Behavior | 1997 |
Optimal scoring strategies and weights for the formalin test in rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Bradykinin; Dose-Response Relationship, Drug; Formaldehyde; Morphine; Osmolar Concentration; Pain; Pain Measurement; Rats; Regression Analysis | 1997 |
The role of corticosterone in the blockade of tolerance to morphine analgesia by formalin-induced pain in the rat.
Topics: Animals; Corticosterone; Drug Tolerance; Formaldehyde; Male; Metyrapone; Morphine; Narcotics; Pain; Rats | 1997 |
[The search for morphine fragments in hepatic tissue fixed in formalin or paraffin drawn from autopsy bodies].
Topics: Autopsy; Formaldehyde; Gas Chromatography-Mass Spectrometry; Humans; Liver; Morphine; Paraffin Embedding; Peptide Fragments | 1997 |
Formalin-evoked Fos expression in spinal cord is enhanced in morphine-tolerant rats.
Topics: Animals; Drug Tolerance; Formaldehyde; Hindlimb; Hyperalgesia; Male; Morphine; Narcotics; Pain; Placebos; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord | 1997 |
Isobolographic analysis of interaction between intrathecal morphine and clonidine in the formalin test in rats.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Formaldehyde; Injections, Spinal; Male; Morphine; Pain Measurement; Psychomotor Performance; Rats; Rats, Wistar | 1997 |
Orphanin FQ potentiates formalin-induced pain behavior and antagonizes morphine analgesia in rats.
Topics: Analgesia; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Formaldehyde; Male; Morphine; Narcotic Antagonists; Nociceptin; Oligonucleotides, Antisense; Opioid Peptides; Pain; Rats; Rats, Sprague-Dawley | 1997 |
The interaction of FK409, a novel nitric oxide releaser, and peripherally administered morphine during experimental inflammation.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Formaldehyde; Inflammation; Injections, Subcutaneous; Male; Morphine; Nitric Oxide; Nitro Compounds; Pain; Rats; Rats, Sprague-Dawley | 1998 |
Altered nociception, analgesia and aggression in mice lacking the receptor for substance P.
Topics: Aggression; Analgesia; Analgesics, Opioid; Animals; Electric Stimulation; Electromyography; Female; Formaldehyde; Gene Targeting; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Mutagenesis; Neuritis; Pain; Pain Threshold; Physical Stimulation; Receptors, Neurokinin-1; Stress, Physiological; Substance P | 1998 |
Evidence for the involvement of the nitric oxide-cGMP pathway in the antinociception of morphine in the formalin test.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Cyclic AMP; Enzyme Inhibitors; Formaldehyde; Guanylate Cyclase; In Vitro Techniques; Male; Methylene Blue; Morphine; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Pain Measurement; Rats; Rats, Wistar | 1997 |
ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective antinociceptive agent acting via neuronal nicotinic acetylcholine receptors: II. In vivo characterization.
Topics: Administration, Oral; Analgesics, Non-Narcotic; Animals; Azetidines; Electroencephalography; Formaldehyde; Male; Morphine; Motor Activity; Nicotinic Agonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 1998 |
(-)-Norpseudoephedrine, a metabolite of cathinone with amphetamine-like stimulus properties, enhances the analgesic and rate decreasing effects of morphine, but inhibits its discriminative properties.
Topics: Alkaloids; Amphetamine; Analgesics, Opioid; Animals; Central Nervous System Stimulants; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Synergism; Female; Formaldehyde; Male; Mice; Morphine; Pain Measurement; Phenylpropanolamine; Rats; Rats, Sprague-Dawley; Reaction Time | 1998 |
Morphine analgesia in the formalin test: reversal by microinjection of quaternary naloxone into the posterior hypothalamic area or periaqueductal gray.
Topics: Analgesics, Opioid; Animals; Formaldehyde; Hypothalamus, Posterior; Male; Microinjections; Morphine; Naloxone; Narcotic Antagonists; Pain Measurement; Periaqueductal Gray; Rats | 1998 |
Antinociceptive effects of morphine were different between experimental and genetic diabetes.
Topics: Analgesics, Opioid; Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Formaldehyde; Male; Mice; Morphine; Pain Measurement; Serotonin Receptor Agonists | 1998 |
Antinociceptive effect of meloxicam, in neurogenic and inflammatory nociceptive models in mice.
Topics: Abdominal Muscles; Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Capsaicin; Cyclooxygenase Inhibitors; Diclofenac; Formaldehyde; Inflammation; Male; Meloxicam; Mice; Morphine; Muscle Contraction; Pain; Pain Measurement; Reaction Time; Thiazines; Thiazoles | 1998 |
A lateralized deficit in morphine antinociception after unilateral inactivation of the central amygdala.
Topics: Afferent Pathways; Amygdala; Animals; Behavior, Animal; Disinfectants; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Fear; Formaldehyde; GABA Agonists; Hindlimb; Hyperalgesia; Locomotion; Male; Morphine; Muscimol; N-Methylaspartate; Narcotics; Nociceptors; Pain; Rats; Rats, Sprague-Dawley | 1998 |
Role of the kappa-opioid system in the attenuation of the morphine-induced place preference under chronic pain.
Topics: Animals; Chronic Disease; Conditioning, Psychological; Formaldehyde; Hindlimb; Inflammation; Male; Morphine; Naltrexone; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Reward; Time Factors | 1999 |
Morphine reversed formalin-induced CA1 pyramidal cell suppression via an effect on septohippocampal neural processing.
Topics: Action Potentials; Animals; Disinfectants; Formaldehyde; Hippocampus; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nociceptors; Pain; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Septal Nuclei; Theta Rhythm | 1999 |
Modulation of formalin-evoked hyperalgesia by intrathecal N-type Ca channel and protein kinase C inhibitor in the rat.
Topics: Analgesics, Opioid; Animals; Calcium Channel Blockers; Calcium Channels; Carcinogens; Disinfectants; Enzyme Inhibitors; Formaldehyde; Glutamic Acid; Hyperalgesia; Injections, Spinal; Male; Microdialysis; Morphine; Nociceptors; omega-Conotoxin GVIA; Peptides; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Staurosporine; Synapses | 1999 |
Effects of CCK antagonists on GABA mechanism-induced antinociception in the formalin test.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Baclofen; Dose-Response Relationship, Drug; Formaldehyde; GABA Agents; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Isoxazoles; Male; Mice; Morphine; Pain; Pain Measurement; Receptors, Cholecystokinin | 1999 |
Antinociceptive properties of the new alkaloid, cis-8, 10-di-N-propyllobelidiol hydrochloride dihydrate isolated from Siphocampylus verticillatus: evidence for the mechanism of action.
Topics: Abdominal Muscles; Acetic Acid; Alkaloids; Analgesics; Analgesics, Opioid; Animals; Capsaicin; Female; Formaldehyde; Gastrointestinal Transit; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Pain Measurement; Piperidines; Plants, Medicinal; Postural Balance; Reaction Time; Vas Deferens | 1999 |
A murine model for Down syndrome shows reduced responsiveness to pain.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Down Syndrome; Escape Reaction; Formaldehyde; Hot Temperature; Mice; Morphine; Nociceptors; Pain; Pain Measurement; Pain Threshold; Reaction Time; Reference Values | 1999 |
Alendronate induces antinociception in mice, not related with its effects in bone.
Topics: Acetic Acid; Alendronate; Analgesics; Animals; Bone Density; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Morphine; Nociceptors; Pain; Pain Measurement; Rats; Rats, Wistar; Time Factors | 1999 |
Antinociceptive effects of the tubercles of Anredera leptostachys.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Caribbean Region; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Escape Reaction; Exploratory Behavior; Formaldehyde; Hot Temperature; Male; Medicine, Traditional; Methanol; Mice; Morphine; Muscle Relaxation; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Plant Extracts; Solubility; Time Factors | 1999 |
Differential modulation by baclofen on antinociception induced by morphine and beta-endorphin administered intracerebroventricularly in the formalin test.
Topics: Analgesics, Opioid; Animals; Baclofen; beta-Endorphin; Brain Chemistry; Fixatives; Formaldehyde; GABA Agonists; Hot Temperature; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Muscimol; Nociceptors; Pain Threshold; Receptors, GABA-A; Receptors, GABA-B | 1999 |
Interactions of intrathecally administered ziconotide, a selective blocker of neuronal N-type voltage-sensitive calcium channels, with morphine on nociception in rats.
Topics: Analgesics, Opioid; Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Drug Administration Schedule; Drug Synergism; Drug Tolerance; Formaldehyde; Hot Temperature; Injections, Spinal; Male; Morphine; Nociceptors; omega-Conotoxins; Pain; Pain Measurement; Pressure; Rats; Rats, Sprague-Dawley | 2000 |
Formalin-induced central sensitization in the rat: somatosensory evoked potential data.
Topics: Animals; Cerebral Cortex; Electric Stimulation; Evoked Potentials, Somatosensory; Formaldehyde; Hyperesthesia; Ketamine; Male; Morphine; Pain; Rats; Rats, Wistar; Time Factors | 2000 |
The role of formalin-induced pain in morphine tolerance, withdrawal, and reward.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Formaldehyde; Male; Morphine; Pain; Pain Measurement; Rats; Rats, Long-Evans; Reward; Substance Withdrawal Syndrome | 2000 |
Interaction between intrathecal morphine and glutamate receptor antagonists in formalin test.
Topics: 2-Amino-5-phosphonovalerate; Analgesics, Opioid; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Formaldehyde; Injections, Spinal; Male; Morphine; Motor Activity; Pain; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 2000 |
Sildenafil produces antinociception and increases morphine antinociception in the formalin test.
Topics: Analgesics; Animals; Cyclic GMP; Drug Synergism; Female; Formaldehyde; Guanylate Cyclase; Morphine; Naloxone; NG-Nitroarginine Methyl Ester; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Wistar; Sildenafil Citrate; Sulfones | 2000 |
Saccharin effects on morphine-induced antinociception in the mouse formalin test.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Morphine; Naloxone; Saccharin; Sweetening Agents | 2000 |
Pharmacological validation of an automated method of pain scoring in the formalin test in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Automation; Behavior, Animal; Drug Interactions; Formaldehyde; Image Processing, Computer-Assisted; Male; Morphine; Naloxone; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Serotonin | 1999 |
Peripheral antinociceptive interaction of dipyrone and morphine in the formalin test.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Formaldehyde; Morphine; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pain Measurement; Peripheral Nervous System; Rats; Rats, Wistar | 2000 |
Effect of imipramine on tolerance to morphine antinociception in the formalin test.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Disinfectants; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Formaldehyde; Imipramine; Injections, Intraperitoneal; Male; Mice; Morphine; Naloxone; Pain | 2000 |
Effect of chronic and acute administration of fluoxetine and its additive effect with morphine on the behavioural response in the formalin test in rats.
Topics: 5,7-Dihydroxytryptamine; Analgesics, Opioid; Animals; Drug Synergism; Fluoxetine; Formaldehyde; Injections, Intraperitoneal; Male; Morphine; Naloxone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin Agents; Time Factors | 2001 |
Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in alpha CGRP-deficient mice.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Carrageenan; Fixatives; Formaldehyde; Ganglionic Stimulants; Inflammation; Magnesium Sulfate; Mice; Mice, Transgenic; Morphine; Naloxone; Narcotic Antagonists; Nicotine; Opioid-Related Disorders; Pain; Substance Withdrawal Syndrome | 2001 |
3-Methyl-5-hydroxy-5-trichloromethyl-1H-1-pyrazolcarboxyamide induces antinociception.
Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Formaldehyde; Immersion; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; Pain Measurement; Postural Balance; Pyrazoles; Rats; Rats, Wistar | 2001 |
[Effects of morphine on the formalin induced IL-2R beta mRNA expression of rat hippocampus].
Topics: Adrenocorticotropic Hormone; Animals; Formaldehyde; Gene Expression; Hippocampus; Morphine; Nociceptors; Pain; Rats; Rats, Wistar; Receptors, Interleukin-2; RNA, Messenger | 1998 |
Interactions of inflammatory pain and morphine in infant rats: long-term behavioral effects.
Topics: Alcohol Drinking; Animals; Animals, Newborn; Arousal; Chronic Disease; Female; Formaldehyde; Inflammation; Injections, Subcutaneous; Male; Morphine; Motor Activity; Pain; Pain Threshold; Pregnancy; Premedication; Rats; Rats, Long-Evans | 2001 |
Tolerance to analgesia and dependence liability by topical application of dihydroetorphine to hairless rats.
Topics: Administration, Cutaneous; Analgesics, Opioid; Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Tolerance; Etorphine; Formaldehyde; Inflammation; Infusions, Intravenous; Injections, Subcutaneous; Male; Morphine; Naloxone; Narcotic Antagonists; Rats; Rats, Nude; Substance-Related Disorders; Time Factors; Weight Loss | 2001 |
Heme oxygenase inhibitors reduce formalin-induced Fos expression in mouse spinal cord tissue.
Topics: Animals; Enzyme Inhibitors; Formaldehyde; Heme Oxygenase (Decyclizing); Hindlimb; Injections; Male; Metalloporphyrins; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Proto-Oncogene Proteins c-fos; Protoporphyrins; Spinal Cord; Tissue Distribution | 2001 |
Facilitation of enkephalins catabolism inhibitor-induced antinociception by drugs classically used in pain management.
Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Disulfides; Enkephalins; Enzyme Inhibitors; Formaldehyde; Injections, Intravenous; Injections, Subcutaneous; Male; Mice; Morphine; Neprilysin; Pain; Pain Measurement; Phenylalanine; Pressure; Rats; Rats, Sprague-Dawley; Reaction Time | 2001 |
The stability of tetramine, morphine and meperidine in formalin solution.
Topics: Animals; Bridged-Ring Compounds; Cryopreservation; Drug Stability; Fixatives; Forensic Medicine; Formaldehyde; GABA Antagonists; Heart; Kidney; Liver; Lung; Meperidine; Morphine; Narcotics; Rabbits | 2001 |
Analgesic and antipyretic activities of Rumex patientia extract on mice and rabbits.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Aspirin; Fever; Formaldehyde; Indomethacin; Lipopolysaccharides; Male; Mice; Morphine; Pain Measurement; Plant Extracts; Plant Roots; Plants, Medicinal; Polygonaceae; Rabbits; Salmonella typhi | 2001 |
Cervicomedullary intrathecal injection of morphine produces antinociception in the orofacial formalin test in the rat.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Blood Gas Analysis; Face; Formaldehyde; Hemodynamics; Injections; Injections, Spinal; Male; Morphine; Motor Activity; Mouth; Naloxone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Wistar | 2001 |
Comparison of the peripheral and central effects of the opioid agonists loperamide and morphine in the formalin test in rats.
Topics: Analgesics, Opioid; Animals; Antidiarrheals; Cisterna Magna; Dose-Response Relationship, Drug; Formaldehyde; Injections; Injections, Subcutaneous; Loperamide; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2002 |
Magnesium increases morphine analgesic effect in different experimental models of pain.
Topics: Analgesics, Opioid; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Drug Synergism; Formaldehyde; Magnesium; Male; Morphine; Pain; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Pressure; Rats; Rats, Sprague-Dawley; Vocalization, Animal | 2002 |
Nociceptive behaviour induced by dental application of irritants to rat incisors: a new model for tooth inflammatory pain.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Crowns; Cyclooxygenase Inhibitors; Dental Pulp Cavity; Disease Models, Animal; Drug Interactions; Female; Formaldehyde; Gingiva; Inflammation; Male; Meloxicam; Morphine; Naloxone; Narcotic Antagonists; Nerve Fibers; Nociceptors; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiazines; Thiazoles; Toothache | 2002 |
Pharmacological evidence for the activation of K(+) channels by diclofenac.
Topics: 4-Aminopyridine; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apamin; Behavior, Animal; Charybdotoxin; Diclofenac; Dose-Response Relationship, Drug; Female; Formaldehyde; Glyburide; Hindlimb; Morphine; Pain; Pinacidil; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Tetraethylammonium; Tolbutamide | 2002 |
Effect of intracerebroventricular injection of GABA receptor agents on morphine-induced antinociception in the formalin test.
Topics: Analgesics, Opioid; Animals; Baclofen; Bicuculline; Dose-Response Relationship, Drug; Formaldehyde; GABA Agents; GABA Agonists; GABA Antagonists; Injections, Intraventricular; Male; Morphine; Muscimol; Organophosphorus Compounds; Pain Measurement; Rats; Receptors, GABA | 2002 |
[Increased expression of formalin-induced Fos and NADPH-d positive neurons in the spinal cord of morphine-tolerant rats].
Topics: Animals; Drug Tolerance; Formaldehyde; Male; Morphine; NADPH Dehydrogenase; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pain; Proto-Oncogene Proteins c-fos; Random Allocation; Rats; Rats, Sprague-Dawley; Spinal Cord | 2000 |
Evidence for the involvement of glutamatergic receptors in the antinociception caused in mice by the sesquiterpene drimanial.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drimys; Excitatory Amino Acids; Formaldehyde; Glutamic Acid; Injections, Spinal; Male; Mice; Morphine; Pain Measurement; Postural Balance; Psychomotor Performance; Receptors, Glutamate; Sesquiterpenes; Substance P | 2002 |
The role of contextual cues on counterirritation in the development process of analgesic tolerance to morphine.
Topics: Analgesics, Opioid; Animals; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Drug Tolerance; Extinction, Psychological; Formaldehyde; Hot Temperature; Irritants; Male; Morphine; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time | 2002 |
Mechanisms involved in the antinociception caused by compound MV8612 isolated from Mandevilla velutina in mice.
Topics: Analgesics; Animals; Apamin; Bradykinin; Capsaicin; Charybdotoxin; Formaldehyde; Glyburide; Glycosides; GTP-Binding Proteins; Hot Temperature; Hyperalgesia; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Pain; Pertussis Toxin; Potassium Channel Blockers; Potassium Channels; Steroids; Tetraethylammonium | 2003 |
Modulation of spinal nociceptive processing through the glutamate transporter GLT-1.
Topics: Analgesics, Opioid; Animals; Blotting, Western; Cell Culture Techniques; Dicarboxylic Acids; Excitatory Amino Acid Transporter 2; Formaldehyde; Male; Morphine; Neurotransmitter Uptake Inhibitors; Oligoribonucleotides, Antisense; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Spinal Cord; Up-Regulation | 2003 |
Effects of morphine on formalin-induced nociception in rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Formaldehyde; Hindlimb; Male; Morphine; Nociceptors; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley | 2003 |
Functional magnetic resonance imaging of tonic pain and vasopressor effects in rats.
Topics: Analgesics, Opioid; Animals; Blood Pressure; Brain Mapping; Cerebral Cortex; Cerebrovascular Circulation; Formaldehyde; Magnetic Resonance Imaging; Morphine; Norepinephrine; Oxygen; Pain; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents | 2002 |
The analgesic, antipyretic and anti-inflammatory activity of Diospyros variegata Kruz.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diospyros; Fever; Formaldehyde; Hexanes; Inflammation; Male; Methanol; Mice; Morphine; Pain; Pain Measurement; Phenylbutazone; Plant Extracts; Rats; Rats, Sprague-Dawley; Reaction Time; Solvents | 2003 |
Lactoferrin enhances opioid-mediated analgesia via nitric oxide in the rat spinal cord.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Formaldehyde; Lactoferrin; Male; Morphine; Narcotics; Nitric Oxide; Nitric Oxide Synthase; Pain; Rats; Rats, Inbred Strains; Spinal Cord | 2003 |
Endomorphin-2, deltorphin II and their analogs suppress formalin-induced nociception and c-Fos expression in the rat spinal cord.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Formaldehyde; Inflammation; Male; Morphine; Nociceptors; Oligopeptides; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Time Factors | 2003 |
Hyperalgesic effects of gamma-aminobutyric acid transporter I in mice.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Brain; Carrier Proteins; Dose-Response Relationship, Drug; Drug Tolerance; Formaldehyde; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Hyperalgesia; Male; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morphine; Nipecotic Acids; Organic Anion Transporters; Oximes; Pain Measurement; Reaction Time; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spinal Cord; Substance-Related Disorders; Synaptosomes; Time Factors | 2003 |
DRUGS RELATED TO THE EXACERBATION OR AMELIORATION OF HEPATIC COMA AND THEIR EFFECTS ON AMMONIA TOXICITY.
Topics: Acetazolamide; Ammonia; Ammonium Chloride; Arginine; Chlorothiazide; Cortisone; Formaldehyde; Glutamates; Hepatic Encephalopathy; Hydrogen-Ion Concentration; Iproniazid; Mice; Morphine; Paraldehyde; Pentobarbital; Phenobarbital; Research; Toxicology; Tryptophan | 1963 |
Evidence that nitric oxide-glutamate cascade modulates spinal antinociceptive effect of morphine: a behavioural and microdialysis study in rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Drug Synergism; Enzyme Inhibitors; Extracellular Fluid; Formaldehyde; Glutamic Acid; Injections, Spinal; Male; Microdialysis; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord | 2003 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Edema; Formaldehyde; Glutamic Acid; Inhibition, Psychological; Injections, Subcutaneous; Male; Morphine; Motor Activity; Narcotics; Neuromuscular Agents; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Time Factors | 2004 |
[Effects of adrenalectomy on the thermoanalgesic phenomena provoked by cortisone, ACTH, formalin, epinephrine, morphine & pyramidone].
Topics: Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Antipyrine; Cortisone; Epinephrine; Formaldehyde; Humans; Morphine | 1951 |
Effects of coadministration of cannabinoids and morphine on nociceptive behaviour, brain monoamines and HPA axis activity in a rat model of persistent pain.
Topics: Animals; Behavior, Animal; Biogenic Monoamines; Body Temperature; Brain; Brain Chemistry; Cannabidiol; Chromatography, High Pressure Liquid; Corticosterone; Disease Models, Animal; Dronabinol; Drug Interactions; Formaldehyde; Male; Morphine; Motor Activity; Narcotics; Pain; Pain Measurement; Psychotropic Drugs; Radioimmunoassay; Rats; Time Factors | 2004 |
Involvement of spinal lipoxygenase metabolites in hyperalgesia and opioid tolerance.
Topics: Analgesics, Opioid; Animals; Benzoquinones; Dose-Response Relationship, Drug; Drug Tolerance; Flavanones; Formaldehyde; Hindlimb; Hyperalgesia; Injections, Spinal; Leukotriene B4; Leukotrienes; Lipid Peroxides; Lipoxygenase; Lipoxygenase Inhibitors; Male; Masoprocol; Morphine; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord; Time Factors | 2004 |
Synergistic antinociceptive effect of amitriptyline and morphine in the rat orofacial formalin test.
Topics: Amitriptyline; Analgesics, Opioid; Animals; Antidepressive Agents; Dose-Response Relationship, Drug; Drug Synergism; Facial Pain; Formaldehyde; Male; Morphine; Motor Activity; Pain Measurement; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Reaction Time | 2004 |
Direct evidence for the involvement of the mesolimbic kappa-opioid system in the morphine-induced rewarding effect under an inflammatory pain-like state.
Topics: Animals; Brain Chemistry; Conditioning, Operant; Dopamine; Dynorphins; Edema; Foot; Formaldehyde; Inflammation; Limbic System; Male; Microdialysis; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reward | 2005 |
The analgesic and anti-inflammatory effects of subcutaneous bupivacaine, morphine and tramadol in rats.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Bupivacaine; Formaldehyde; Inflammation; Injections, Subcutaneous; Male; Morphine; Pain; Pain Measurement; Random Allocation; Rats; Rats, Sprague-Dawley; Tramadol | 2004 |
Peripheral versus central antinociceptive actions of 6-amino acid-substituted derivatives of 14-O-methyloxymorphone in acute and inflammatory pain in the rat.
Topics: Acute Disease; Analgesics; Animals; Central Nervous System; Dose-Response Relationship, Drug; Fentanyl; Formaldehyde; Inflammation; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Morphine Derivatives; Pain; Pain Measurement; Peripheral Nervous System; Rats; Rats, Wistar; Reaction Time | 2005 |
An antisense oligonucleotide to the N-methyl-D-aspartate (NMDA) subunit NMDAR1 attenuates NMDA-induced nociception, hyperalgesia, and morphine tolerance.
Topics: Analgesics, Opioid; Animals; Autoradiography; Behavior, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Formaldehyde; Glycine; Hyperalgesia; Indoles; Injections, Spinal; Morphine; N-Methylaspartate; Narcotics; Oligonucleotides, Antisense; Pain; Pain Measurement; Rats; Reaction Time; Receptors, N-Methyl-D-Aspartate; RNA Probes; RNA, Messenger; Spinal Cord | 2005 |
Effects of intrathecal BAM22 on noxious stimulus-evoked c-fos expression in the rat spinal dorsal horn.
Topics: Animals; Cattle; Cell Count; Drug Interactions; Enkephalin, Methionine; Enkephalins; Formaldehyde; Gene Expression Regulation; Hot Temperature; Immunohistochemistry; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Pain; Pain Measurement; Physical Stimulation; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord | 2004 |
Antinociceptive effects of intrathecally administered huwentoxin-I, a selective N-type calcium channel blocker, in the formalin test in conscious rats.
Topics: Analgesics; Animals; Calcium Channel Blockers; Dose-Response Relationship, Drug; Female; Formaldehyde; Injections, Spinal; Male; Morphine; Neurotoxins; omega-Conotoxins; Rats; Rats, Sprague-Dawley; Reptilian Proteins; Spider Venoms | 2005 |
Validation of a simple automated movement detection system for formalin test in rats.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Formaldehyde; Injections, Subcutaneous; Lidocaine; Male; Morphine; Nociceptors; Pain Measurement; Rats; Rats, Sprague-Dawley; Reproducibility of Results | 2005 |
Antinociceptive properties of ethanolic extract and fractions of Pterodon pubescens Benth. seeds.
Topics: Abdomen; Administration, Oral; Analgesics; Animals; Aspirin; Chemical Fractionation; Dipyrone; Diterpenes; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Ethanol; Fabaceae; Formaldehyde; Gas Chromatography-Mass Spectrometry; Inflammation; Male; Mice; Morphine; Pain Measurement; Plant Extracts; Plant Oils; Seeds; Sesquiterpenes; Tail; Temperature | 2005 |
Functional magnetic resonance imaging studies of opioid receptor-mediated modulation of noxious-evoked BOLD contrast in rats.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Brain; Brain Mapping; Drug Interactions; Formaldehyde; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Morphine; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid | 2005 |
[Effect of intrathecal pumping morphine on immunological function in rats with formalin pain].
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Formaldehyde; Immunosuppressive Agents; Injections, Spinal; Killer Cells, Natural; Male; Morphine; Pain; Pain Measurement; Random Allocation; Rats; Rats, Sprague-Dawley; T-Lymphocyte Subsets | 2005 |
Effects of the high-efficacy 5-HT1A receptor agonist, F 13640 in the formalin pain model: a c-Fos study.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Disease Models, Animal; Formaldehyde; Male; Morphine; Pain; Pain Measurement; Piperidines; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Rats, Sprague-Dawley; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists; Spinal Cord; Time Factors | 2005 |
Antinociceptive effects of haloperidol and its metabolites in the formalin test in mice.
Topics: Analgesics; Analysis of Variance; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Formaldehyde; Haloperidol; Mice; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Pain; Pain Measurement; Time Factors | 2005 |
Evidence for an intrinsic mechanism of antinociceptive tolerance within the ventrolateral periaqueductal gray of rats.
Topics: Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Formaldehyde; GABA Agonists; GABA-A Receptor Agonists; Male; Medulla Oblongata; Morphine; Muscimol; Naltrexone; Narcotic Antagonists; Neurons; Pain Measurement; Periaqueductal Gray; Rats; Rats, Sprague-Dawley | 2005 |
The effects of restraint stress on nociceptive responses induced by formalin injected in rat's TMJ.
Topics: Adrenocorticotropic Hormone; Analgesics, Opioid; Animals; Behavior, Animal; Corticosterone; Formaldehyde; Injections; Male; Morphine; Naloxone; Narcotic Antagonists; Nociceptors; Pain Measurement; Rats; Rats, Wistar; Restraint, Physical; Stress, Psychological; Temporomandibular Joint | 2005 |
Cross-tolerance between antinociception induced by swim-stress and morphine in formalin test.
Topics: Analgesia; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Formaldehyde; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; Pain Measurement; Stress, Psychological; Swimming | 2005 |
Antinociceptive effects and synergistic interaction with morphine of intrathecal metabotropic glutamate receptor 2/3 antagonist in the formalin test of rats.
Topics: Amino Acids; Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Formaldehyde; Injections, Spinal; Male; Morphine; Pain Measurement; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Reflex; Xanthenes | 2006 |
Analgesic effects of morphine and loperamide in the rat formalin test: interactions with NMDA receptor antagonists.
Topics: Analgesics, Opioid; Animals; Excitatory Amino Acid Antagonists; Formaldehyde; Hot Temperature; Loperamide; Male; Morphine; Motor Skills; Narcotic Antagonists; Pain; Pain Measurement; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid | 2005 |
Synergistic antinociception between zaprinast and morphine in the spinal cord of rats on the formalin test.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Synergism; Formaldehyde; Injections, Spinal; Male; Morphine; Muscle Tonus; Pain; Pain Measurement; Phosphodiesterase Inhibitors; Purinones; Rats; Rats, Sprague-Dawley; Reflex | 2006 |
Effects of ketamine on acute somatic nociception in wild-type and N-methyl-D-aspartate (NMDA) receptor epsilon1 subunit knockout mice.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Formaldehyde; Hot Temperature; Hyperalgesia; Ketamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Nociceptors; Pain; Pain Measurement; Receptors, N-Methyl-D-Aspartate | 2006 |
Acute and chronic morphine alters formalin pain in neonatal rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Formaldehyde; Male; Morphine; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Time Factors | 2006 |
Morphine antinociceptive potency on chemical, mechanical, and thermal nociceptive tests in the rat.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Formaldehyde; Hot Temperature; Male; Morphine; Motor Activity; Pain Measurement; Pain Threshold; Physical Stimulation; Pressure; Rats; Rats, Sprague-Dawley | 2006 |
Antinociceptive effects of tetrodotoxin (TTX) in rodents.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Hot Temperature; Hyperalgesia; Male; Mice; Morphine; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Wistar; Tetrodotoxin | 2006 |
Enhancement of morphine antinociception with the peptide N-methyl-D-aspartate receptor antagonist [Ser1]-histogranin in the rat formalin test.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Formaldehyde; Injections, Spinal; Ketamine; Male; Morphine; Pain; Proteins; Rats; Rats, Sprague-Dawley; Time Factors | 2006 |
Analgesic effects of mGlu1 and mGlu5 receptor antagonists in the rat formalin test.
Topics: Analgesics; Analysis of Variance; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Formaldehyde; Male; Morphine; Pain; Pain Measurement; Pain Threshold; Pyridines; Quinolines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Thiazoles | 2006 |
Lack of reciprocity between opioid and 5-HT3 receptors for antinociception in rat spinal cord.
Topics: Analgesia; Analgesics, Opioid; Animals; Biguanides; Dose-Response Relationship, Drug; Formaldehyde; Hindlimb; Indazoles; Injections, Spinal; Male; Morphine; Motor Activity; Muscle Tonus; Naloxone; Narcotic Antagonists; Ondansetron; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Antagonists; Serotonin Receptor Agonists; Spinal Cord; Tropanes | 2006 |
Peripheral participation of cholecystokinin in the morphine-induced peripheral antinociceptive effect in non-diabetic and diabetic rats.
Topics: Animals; Area Under Curve; Cholecystokinin; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Interactions; Formaldehyde; Male; Morphine; Narcotics; Neuralgia; Pain Measurement; Pain Threshold; Peptide Fragments; Proglumide; Rats; Rats, Wistar | 2007 |
The orofacial formalin test in the mouse: a behavioral model for studying physiology and modulation of trigeminal nociception.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Facial Pain; Formaldehyde; Lip; Male; Mice; Morphine; Narcotics; Nociceptors; Pain Measurement; Psychomotor Performance; Trigeminal Nerve | 2006 |
Antinociceptive effects of the aqueous extract of Brugmansia suaveolens flowers in mice.
Topics: Acetic Acid; Analgesics; Analysis of Variance; Animals; Diclofenac; Disease Models, Animal; Drug Evaluation, Preclinical; Flowers; Formaldehyde; Injections, Intraperitoneal; Male; Mice; Morphine; Pain; Pain Measurement; Phytotherapy; Plant Extracts; Reaction Time; Solanaceae; Treatment Outcome | 2007 |
Different effects of morphine and morphine-6beta-glucuronide on formalin-evoked spinal glutamate release in conscious and freely moving rats.
Topics: Animals; Area Under Curve; Dose-Response Relationship, Drug; Drug Interactions; Formaldehyde; Glutamic Acid; Male; Morphine; Morphine Derivatives; Narcotics; Pain Measurement; Rats; Spinal Cord; Time Factors; Wakefulness | 2007 |
Morphine-induced antinociception in the formalin test: sensitization and interactions with D1 and D2 dopamine receptors and nitric oxide agents.
Topics: Analgesics, Opioid; Animals; Arginine; Benzazepines; Dopamine Antagonists; Dose-Response Relationship, Drug; Enzyme Inhibitors; Formaldehyde; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain Measurement; Receptors, Dopamine D1; Receptors, Dopamine D2; Sulpiride | 2007 |
Antinociceptive activity of Syzygium jambos leaves extract on rats.
Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-Response Relationship, Drug; Formaldehyde; Hand Strength; Hot Temperature; Male; Morphine; Muscle, Skeletal; Naloxone; Narcotic Antagonists; Pain Measurement; Plant Extracts; Plant Leaves; Rats; Rats, Sprague-Dawley; Reaction Time; Syzygium | 2007 |
Analgesia induced by morphine microinjected into the nucleus raphe magnus: effects on tonic pain.
Topics: Analgesia; Analgesics, Opioid; Animals; Disease Models, Animal; Formaldehyde; Male; Microinjections; Morphine; Pain; Pain Measurement; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Tail | 2007 |
Involvement of kappa opioid receptors in formalin-induced inhibition of analgesic tolerance to morphine in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Chronic Disease; Drug Tolerance; Formaldehyde; Male; Mice; Morphine; Naltrexone; Oligonucleotides, Antisense; Pain; Pain Measurement; Pain Threshold; Receptors, Opioid, delta; Receptors, Opioid, kappa; Tail | 2007 |
Pharmacological analysis of paregoric elixir and its constituents: in vitro and in vivo studies.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Drug Tolerance; Electric Stimulation; Female; Formaldehyde; Gastrointestinal Transit; Lethal Dose 50; Male; Mice; Morphine; Motor Activity; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Opium; Pain Measurement; Papaverine; Parasympatholytics; Spectrophotometry, Ultraviolet | 2007 |
A novel automated method for measuring the effect of analgesics on formalin-evoked licking behavior in rats.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electronic Data Processing; Formaldehyde; Male; Morphine; Narcotics; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley | 2008 |
Multivariate calibration applied to the time-resolved chemiluminescence for the simultaneous determination of morphine and its antagonist naloxone.
Topics: Acids; Calibration; Formaldehyde; Luminescent Measurements; Molecular Structure; Morphine; Naloxone; Potassium; Temperature; Time Factors | 2007 |
Alterations in attentional mechanisms in response to acute inflammatory pain and morphine administration.
Topics: Analgesics, Opioid; Animals; Attention; Data Interpretation, Statistical; Formaldehyde; Inflammation; Male; Morphine; Pain; Pain Measurement; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Reaction Time | 2008 |
Antinociceptive activity of n-butanol fraction from MeOH extracts of Paederia scandens in mice.
Topics: 1-Butanol; Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Capsaicin; Constriction, Pathologic; Formaldehyde; Hot Temperature; Hypnotics and Sedatives; Methanol; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Pain Measurement; Pentobarbital; Plant Extracts; Reaction Time; Rubiaceae; Sleep; Solvents | 2007 |
Further antinociceptive properties of extracts and phenolic compounds from Plinia glomerata (Myrtaceae) leaves.
Topics: Acetic Acid; Acetone; Analgesics; Analgesics, Opioid; Animals; Capsaicin; Ellagic Acid; Formaldehyde; Glutamic Acid; Hot Temperature; Injections, Intraperitoneal; Male; Methanol; Mice; Morphine; Myrtaceae; Pain Measurement; Phenols; Plant Extracts; Plant Leaves; Solvents | 2008 |
Antinociceptive effects of St. John's wort, Harpagophytum procumbens extract and Grape seed proanthocyanidins extract in mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Brain Chemistry; Dose-Response Relationship, Drug; Formaldehyde; Harpagophytum; Hot Temperature; Hypericum; Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Nitrates; Nitrites; Pain Measurement; Plant Extracts; Proanthocyanidins; Reaction Time; Seeds; Spinal Cord; Vitis | 2008 |
The differential effect of morphine and beta-endorphin administered intracerebroventricularly on pERK and pCaMK-II expression induced by various nociceptive stimuli in mice brains.
Topics: Analgesics, Opioid; Animals; beta-Endorphin; Blotting, Western; Brain Chemistry; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Extracellular Signal-Regulated MAP Kinases; Formaldehyde; Immunohistochemistry; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Pain; Paraventricular Hypothalamic Nucleus; Substance P | 2008 |
Simultaneous stopped-flow determination of morphine and naloxone by time-resolved chemiluminescence.
Topics: Calibration; Flow Injection Analysis; Formaldehyde; Luminescent Measurements; Morphine; Naloxone; Potassium Permanganate; Sulfuric Acids; Time | 2008 |
Antinociceptive profile of 2,3,6-trisubstituted piperidine alkaloids: 3-O-acetyl-spectaline and semi-synthetic derivatives of (-)-spectaline.
Topics: Acetic Acid; Acetylcholine; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Female; Formaldehyde; Hot Temperature; Indomethacin; Male; Mice; Morphine; Pain Measurement; Piperidines; Rats; Reaction Time; Stereoisomerism; Structure-Activity Relationship | 2008 |
Cysteine protease inhibitors suppress the development of tolerance to morphine antinociception.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Cysteine Proteinase Inhibitors; Drug Tolerance; Dynorphins; Ethylmaleimide; Formaldehyde; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Morphine; Pain Measurement | 2008 |
Antinociceptive activity of (-)-carvone: evidence of association with decreased peripheral nerve excitability.
Topics: Acetates; Action Potentials; Analgesics; Analgesics, Opioid; Animals; Cyclohexane Monoterpenes; Diazepam; Electrophysiology; Formaldehyde; Hypnotics and Sedatives; Male; Mice; Monoterpenes; Morphine; Naloxone; Narcotic Antagonists; Pain Measurement; Peripheral Nerves; Postural Balance; Stereoisomerism; Sucrose | 2008 |
Anti-inflammatory and antinociceptive activity of Thymus pubescens extract.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dose-Response Relationship, Drug; Edema; Formaldehyde; Male; Mice; Morphine; Pain; Plant Extracts; Rats; Rats, Wistar; Thymus Plant | 2008 |
Interaction between morphine and norketamine enantiomers in rodent models of nociception.
Topics: Analgesics, Opioid; Animals; Constriction, Pathologic; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Drug Tolerance; Excitatory Amino Acid Antagonists; Formaldehyde; Ketamine; Male; Morphine; Motor Activity; Pain; Pain Measurement; Peripheral Nervous System Diseases; Physical Stimulation; Postural Balance; Rats; Rats, Sprague-Dawley; Reaction Time; Stereoisomerism | 2008 |
Brain nociceptive imaging in rats using (18)f-fluorodeoxyglucose small-animal positron emission tomography.
Topics: Analgesics; Analysis of Variance; Animals; Brain; Fluorodeoxyglucose F18; Formaldehyde; Functional Laterality; Lidocaine; Male; Morphine; Pain; Positron-Emission Tomography; Rats; Rats, Wistar | 2008 |
Antinociceptive, antiinflammatory and antipyretic properties of Channa striatus fillet aqueous and lipid-based extracts in rats.
Topics: Amino Acids; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Chloroform; Edema; Fatty Acids; Fishes; Formaldehyde; Inflammation; Lipids; Male; Methanol; Morphine; Muscle, Skeletal; Pain Measurement; Rats; Rats, Sprague-Dawley; Saccharomyces cerevisiae; Solvents; Tissue Extracts; Water | 2008 |
Dexmedetomidine and ST-91 analgesia in the formalin model is mediated by alpha2A-adrenoceptors: a mechanism of action distinct from morphine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analgesics; Animals; Clonidine; Dexmedetomidine; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Gene Expression Regulation; Injections, Spinal; Male; Morphine; Pain; Pain Measurement; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Neurokinin-1; Substance P | 2008 |
Additive antinociception between intrathecal sildenafil and morphine in the rat formalin test.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Synergism; Formaldehyde; Injections, Spinal; Male; Morphine; Naloxone; Narcotic Antagonists; Pain; Pain Management; Pain Measurement; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Time Factors | 2008 |
Local peripheral opioid effects and expression of opioid genes in the spinal cord and dorsal root ganglia in neuropathic and inflammatory pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Formaldehyde; Functional Laterality; Ganglia, Spinal; Gene Expression Regulation; Inflammation; Male; Morphine; Narcotic Antagonists; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Receptors, Opioid; Sciatica; Spinal Cord | 2009 |
[Effect of a simple morphine system injection in some aminoacids in the anterior cingulate cortex during acute pain].
Topics: Acute Disease; Amino Acids; Analgesics, Opioid; Animals; Arginine; Aspartic Acid; Cerebral Cortex; Disinfectants; Formaldehyde; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; Male; Microdialysis; Morphine; Pain; Rats; Rats, Wistar | 2008 |
[Analgesic activity of the aqueous extract from Ximenia Americana].
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Formaldehyde; Mice; Morphine; Olacaceae; Pain Measurement; Phenylbutazone; Plant Bark; Plant Extracts; Plant Stems; Rats; Rats, Wistar; Reaction Time | 2009 |
Antinociceptive effect of the cannabinoid agonist, WIN 55,212-2, in the orofacial and temporomandibular formalin tests.
Topics: Analgesics; Analgesics, Opioid; Anesthetics, Dissociative; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Benzoxazines; Camphanes; Facial Pain; Formaldehyde; Indomethacin; Inflammation; Ketamine; Male; Morphine; Morpholines; Motor Activity; Naphthalenes; Pain; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Temporomandibular Joint Disorders | 2010 |
Antinociceptive activity of Paederosidic Acid Methyl Ester (PAME) from the n-butanol fraction of Paederia scandens in mice.
Topics: 1-Butanol; Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Body Temperature; Capsaicin; Formaldehyde; Glucosides; Hot Temperature; Hypnotics and Sedatives; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Pain Measurement; Pentobarbital; Plant Extracts; Reaction Time; Rubiaceae; Sleep; Solvents | 2009 |
Effects of systemic bicuculline or morphine on formalin-evoked pain-related behaviour and c-Fos expression in trigeminal nuclei after formalin injection into the lip or tongue in rats.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Bicuculline; Formaldehyde; GABA Antagonists; Gene Expression; Genes, fos; Lip; Male; Morphine; Neurons; Pain; Pain Measurement; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Tongue; Trigeminal Ganglion; Trigeminal Nuclei | 2009 |
Opposing actions of neuronal nitric oxide synthase isoforms in formalin-induced pain in mice.
Topics: Analysis of Variance; Animals; Arginine; Drug Tolerance; Formaldehyde; Hyperalgesia; Injections, Spinal; Isoenzymes; Male; Mice; Morphine; Nitric Oxide Synthase Type I; Nitroarginine; Oligodeoxyribonucleotides, Antisense; Pain; Pain Measurement; Pain Threshold | 2009 |
Antinociceptive effects of (O-methyl)-N-benzoyl tyramine (riparin I) from Aniba riparia (Nees) Mez (Lauraceae) in mice.
Topics: Acetic Acid; Administration, Oral; Analgesics; Analgesics, Opioid; Animals; Arginine; Behavior, Animal; Benzamides; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Formaldehyde; Hot Temperature; Injections, Intraperitoneal; Lauraceae; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Measurement; Reaction Time; Time Factors; Tyramine | 2009 |
Formalin-induced differential activation of nucleus cuneiformis neurons in the rat: an electrophysiological study.
Topics: Action Potentials; Analgesics, Opioid; Animals; Behavior, Animal; Central Nervous System Agents; Formaldehyde; Male; Mesencephalon; Microelectrodes; Morphine; Naloxone; Narcotic Antagonists; Neurons; Pain; Pain Measurement; Rats; Rats, Inbred Strains | 2010 |
Role of opioid receptors in the reduction of formalin-induced secondary allodynia and hyperalgesia in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Enkephalin, Leucine-2-Alanine; Female; Formaldehyde; Hyperalgesia; Morphine; Nociceptin Receptor; Pain; Rats; Rats, Wistar; Receptors, Opioid | 2009 |
Evaluation of anti-inflammatory and analgesic activity of a novel rigid 3, 4-dihydroxy chalcone in mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Aspirin; Chalcone; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Formaldehyde; Hot Temperature; Inflammation; Male; Mice; Molecular Structure; Morphine; Naloxone; Narcotic Antagonists; Pain; Pain Measurement | 2009 |
Visualizing acute pain-morphine interaction in descending monoamine nuclei with Fos.
Topics: Analgesics, Opioid; Animals; Brain Stem; Cell Count; Formaldehyde; Immunohistochemistry; Male; Microscopy, Fluorescence; Morphine; Neurons; Norepinephrine; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Serotonin; Time Factors | 2010 |
Role of nitric oxide in the rat hippocampal CA1 in morphine antinociception.
Topics: Analgesics, Opioid; Animals; Arginine; CA1 Region, Hippocampal; Central Nervous System Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Formaldehyde; Inflammation; Male; Morphine; NADPH Dehydrogenase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Measurement; Rats; Rats, Wistar; Time Factors | 2010 |
Preliminary studies on the antinociceptive activity of Vaccinium ashei berry in experimental animal models.
Topics: Acetic Acid; Analgesics; Animals; Anthocyanins; Blueberry Plants; Diclofenac; Disease Models, Animal; Formaldehyde; Fruit; Hot Temperature; Male; Mice; Morphine; Muscle Contraction; Pain; Pain Threshold; Phytotherapy; Plant Extracts | 2010 |
Antinociceptive effect of Zanthoxylum rhoifolium Lam. (Rutaceae) in models of acute pain in rodents.
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Dizocilpine Maleate; Ethanol; Female; Formaldehyde; Glutamic Acid; Locomotion; Male; Mice; Morphine; Pain; Pentacyclic Triterpenes; Phytotherapy; Plant Bark; Plant Extracts; Plant Stems; Zanthoxylum | 2010 |
Spinal antinociception of synthetic omega-conotoxin SO-3, a selective N-type neuronal voltage-sensitive calcium channel blocker, and its effects on morphine analgesia in chemical stimulus tests in rodent.
Topics: Acetic Acid; Analgesics; Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Drug Interactions; Formaldehyde; Injections, Spinal; Locomotion; Male; Mice; Morphine; Neurons; omega-Conotoxins; Pain; Rats | 2010 |
Antinociceptive and anti-inflammatory activities of lectin from marine red alga Pterocladiella capillacea.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Disease Models, Animal; Formaldehyde; Hot Temperature; Indomethacin; Inflammation; Inflammation Mediators; Lectins; Leukocytes; Male; Mice; Morphine; Pain; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Rhodophyta | 2010 |
In vivo analgesic effect of aqueous extract of Tamarindus indica L. fruits.
Topics: Analgesics; Analysis of Variance; Animals; Fixatives; Formaldehyde; Fruit; Male; Mice; Morphine; Naloxone; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Tamarindus | 2010 |
Involvement of kappa opioid receptors in the formalin-induced inhibition of analgesic tolerance to morphine via suppression of conventional protein kinase C activation.
Topics: Analgesics, Opioid; Animals; Brain; Chronic Disease; Disease Models, Animal; Down-Regulation; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Activation; Formaldehyde; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Morphine; Naphthalenes; Oligonucleotides, Antisense; Pain; Pain Measurement; Pain Threshold; Protein Kinase C; Protein Kinase Inhibitors; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors | 2010 |
Antinociceptive effects of citronellal in formalin-, capsaicin-, and glutamate-induced orofacial nociception in rodents and its action on nerve excitability.
Topics: Action Potentials; Acyclic Monoterpenes; Aldehydes; Analgesics; Animals; Capsaicin; Facial Pain; Formaldehyde; Glutamates; Male; Mice; Monoterpenes; Morphine; Motor Activity; Narcotics; Neural Conduction; Nociceptors; Pain; Rats; Rats, Wistar; Sciatic Nerve; Sensory System Agents | 2010 |
Aromatase and 5-alpha reductase gene expression: modulation by pain and morphine treatment in male rats.
Topics: Animals; Aromatase; Behavior, Animal; Brain; Cholestenone 5 alpha-Reductase; Formaldehyde; Gene Expression Regulation, Enzymologic; Male; Morphine; Organ Specificity; Pain; Rats; Rats, Sprague-Dawley; RNA, Messenger; Testosterone | 2010 |
Morphine exposure in early life increases nociceptive behavior in a rat formalin tonic pain model in adult life.
Topics: Age Factors; Analgesics, Opioid; Analysis of Variance; Anesthetics, Dissociative; Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Formaldehyde; Ketamine; Male; Morphine; Pain; Pain Measurement; Rats; Rats, Wistar | 2011 |
Increase in formalin-induced tonic pain by 5alpha-reductase and aromatase inhibition in female rats.
Topics: 5-alpha Reductase Inhibitors; Analgesics, Opioid; Animals; Aromatase Inhibitors; Drug Synergism; Female; Finasteride; Formaldehyde; Letrozole; Morphine; Nitriles; Ovariectomy; Pain; Pain Measurement; Rats; Rats, Wistar; Triazoles | 2011 |
Antinociceptive effect of extract of Emilia sonchifolia in mice.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Asteraceae; Behavior, Animal; Brazil; Disease Models, Animal; Formaldehyde; Hot Temperature; Male; Medicine, Traditional; Mice; Morphine; Naloxone; Pain; Phenols; Phytotherapy; Plant Components, Aerial; Plant Extracts | 2011 |
Reduction of formalin-evoked responses and maintenance of peripheral antinociception by morphine against formalin in the spared nerve injury model.
Topics: Analgesics, Opioid; Animals; Axotomy; Formaldehyde; Hindlimb; Irritants; Male; Morphine; Neuralgia; Rats; Rats, Sprague-Dawley; Sciatic Nerve | 2011 |
Synergistic interaction between intrathecal ginsenosides and morphine on formalin-induced nociception in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Fixatives; Formaldehyde; Gene Expression Regulation; Ginsenosides; Injections, Spinal; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Reflex; Somatostatin | 2011 |
The orofacial formalin test in mice revisited--effects of formalin concentration, age, morphine and analysis method.
Topics: Age Factors; Analgesics, Opioid; Animals; Disease Models, Animal; Facial Pain; Formaldehyde; Irritants; Male; Mice; Mice, Inbred BALB C; Morphine; Pain Measurement | 2011 |
Interaction between histamine and morphine at the level of the hippocampus in the formalin-induced orofacial pain in rats.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Facial Pain; Formaldehyde; Hippocampus; Histamine; Male; Morphine; Naloxone; Pyrilamine; Rats; Rats, Wistar; Receptors, Histamine H1; Receptors, Histamine H2 | 2011 |
Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H(2)LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H(2)LASSBio-1064) and their zinc(II) complexes.
Topics: Acetic Acid; Aldehydes; Analgesics; Animals; Anti-Inflammatory Agents; Coordination Complexes; Crystallography, X-Ray; Dipyrone; Female; Formaldehyde; Hot Temperature; Hydrazones; Indomethacin; Inflammation; Magnetic Resonance Spectroscopy; Male; Mice; Morphine; Pain; Pain Measurement; Peritonitis; Zinc; Zymosan | 2011 |
The combined predictive capacity of rat models of algogen-induced and neuropathic hypersensitivity to clinically used analgesics varies with nociceptive endpoint and consideration of locomotor function.
Topics: Amines; Analgesics; Animals; Capsaicin; Cyclohexanecarboxylic Acids; Disease Models, Animal; Duloxetine Hydrochloride; Exploratory Behavior; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Locomotion; Male; Morphine; Neuralgia; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiophenes | 2012 |
Evaluation of antinociceptive effects of Crassocephalum bauchiense Hutch (Asteraceae) leaf extract in rodents.
Topics: Acetic Acid; Administration, Oral; Alkaloids; Analgesics; Analgesics, Opioid; Animals; Asteraceae; Behavior, Animal; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Formaldehyde; Glutamic Acid; Hot Temperature; Male; Mice; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Pain; Pain Threshold; Phytotherapy; Plant Extracts; Plant Leaves; Plants, Medicinal; Solvents; Time Factors; Water | 2012 |
Inhibition of morphine tolerance is mediated by painful stimuli via central mechanisms.
Topics: Analgesics, Opioid; Animals; Corticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Fluorometry; Formaldehyde; Inflammation; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Morphine; Neuralgia; Pain | 2012 |
Nitric oxide modulated the expression of DREAM/calsenilin/KChIP3 in inflammatory pain of rats.
Topics: Animals; Formaldehyde; Inflammation; Injections, Spinal; Kv Channel-Interacting Proteins; Male; Morphine; Nitric Oxide; Nitroarginine; Pain; Pain Measurement; Random Allocation; Rats; Rats, Sprague-Dawley; Repressor Proteins; RNA, Messenger; Spinal Cord | 2012 |
Effects of repetitive exposure to pain and morphine treatment on the neonatal rat brain.
Topics: Age Factors; Animals; Animals, Newborn; Brain; Disease Models, Animal; Doublecortin Protein; Formaldehyde; Morphine; Narcotics; Nerve Degeneration; Pain; Random Allocation; Rats; Rats, Wistar; Recurrence | 2013 |
The Yin and Yang of pain: variability in formalin test nociception and morphine analgesia produced by the Yin Yang 1 transcription factor gene.
Topics: Analgesia; Analgesics, Opioid; Animals; Cells, Cultured; Formaldehyde; Ganglia, Spinal; Mice; Mice, Inbred C57BL; Morphine; Mutation; NAV1.8 Voltage-Gated Sodium Channel; Neurons; Nociception; Pain; Phenotype; YY1 Transcription Factor | 2013 |
Systemic synergism between codeine and morphine in three pain models in mice.
Topics: Acetic Acid; Acute Pain; Analgesics, Opioid; Animals; Behavior, Animal; Codeine; Disease Models, Animal; Drug Synergism; Formaldehyde; Inflammation; Injections, Intraperitoneal; Injections, Spinal; Male; Mice; Morphine; Pain; Signal Transduction | 2013 |
Antinociceptive synergy between diclofenac and morphine after local injection into the inflamed site.
Topics: Acute Pain; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Formaldehyde; Injections; Male; Morphine; Rats; Rats, Wistar | 2013 |
Analgesic effects of minodronate on formalin-induced acute inflammatory pain in rats.
Topics: Acute Pain; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Diphosphonates; Female; Formaldehyde; Imidazoles; Morphine; Nociception; Pain Measurement; Rats; Rats, Wistar | 2013 |
Naloxone blocks the beneficial effects of aqueous extract of Murraya koenigii (L.) Spreng leaves in models of pain.
Topics: Analgesics; Analgesics, Opioid; Animals; Formaldehyde; Hot Temperature; Male; Mice; Morphine; Murraya; Naloxone; Narcotic Antagonists; Pain Measurement; Plant Extracts; Plant Leaves; Reaction Time | 2013 |
Relative contributions of norepinephrine and serotonin transporters to antinociceptive synergy between monoamine reuptake inhibitors and morphine in the rat formalin model.
Topics: Analgesia; Animals; Atomoxetine Hydrochloride; Biogenic Monoamines; Chromatography, Liquid; Drug Synergism; Duloxetine Hydrochloride; Fluoxetine; Formaldehyde; Morphine; Morpholines; Neurotransmitter Uptake Inhibitors; Nociceptive Pain; Norepinephrine Plasma Membrane Transport Proteins; Ondansetron; Propylamines; Rats; Rotarod Performance Test; Serotonin Plasma Membrane Transport Proteins; Tandem Mass Spectrometry; Thiophenes | 2013 |
β-cyclodextrin complex containing Lippia grata leaf essential oil reduces orofacial nociception in mice - evidence of possible involvement of descending inhibitory pain modulation pathway.
Topics: Animals; beta-Cyclodextrins; Capsaicin; Facial Pain; Formaldehyde; Glutamic Acid; Lippia; Male; Mice; Morphine; Nociception; Oils, Volatile; Pain Measurement; Periaqueductal Gray; Plant Leaves | 2014 |
Possible mechanism involved in the antinociceptive activity of dimer of paederosidic acid and paederosidic acid methyl ester in mice.
Topics: Analgesics; Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Glucosides; Heterocyclic Compounds, 2-Ring; Hyperalgesia; Mice; Mice, Inbred ICR; Morphine; Pain; Pain Measurement; Pain Threshold; Time Factors | 2014 |
Differential pharmacological alleviation of oxaliplatin-induced hyperalgesia/allodynia at cephalic versus extra-cephalic level in rodents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amines; Analgesics; Animals; Cold Temperature; Cyclohexanecarboxylic Acids; Dipeptides; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Organoplatinum Compounds; Oxaliplatin; Piperazines; Piperidines; Quinazolines; Rats; Rats, Sprague-Dawley; Spinal Cord; Touch; TRPA1 Cation Channel; TRPC Cation Channels; Tryptamines | 2014 |
Involvement of cannabinoid receptors in peripheral and spinal morphine analgesia.
Topics: Analgesics, Opioid; Animals; Edema; Formaldehyde; Hindlimb; Hot Temperature; Injections, Intradermal; Injections, Spinal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Nociceptive Pain; Pain Measurement; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid, mu; Spinal Cord | 2014 |
Inferior alveolar nerve transection enhanced formalin-induced nocifensive responses in the upper lip: systemic buprenorphine had more antinociceptive efficacy over morphine.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Buprenorphine; Formaldehyde; Lip; Male; Mandibular Nerve; Morphine; Narcotic Antagonists; Neuralgia; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Trigeminal Nerve Injuries | 2014 |
Sustained pain-related depression of behavior: effects of intraplantar formalin and complete freund's adjuvant on intracranial self-stimulation (ICSS) and endogenous kappa opioid biomarkers in rats.
Topics: Analgesics, Opioid; Animals; Body Weight; Conditioning, Operant; Disease Models, Animal; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Inhibition, Psychological; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Self Stimulation | 2014 |
The role of nicotinic acetylcholine and opioid systems of the ventral orbital cortex in modulation of formalin-induced orofacial pain in rats.
Topics: Analgesics, Opioid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Drug Therapy, Combination; Facial Pain; Formaldehyde; Locomotion; Male; Mecamylamine; Microinjections; Morphine; Naloxone; Narcotic Antagonists; Nicotinic Agonists; Nicotinic Antagonists; Pain Measurement; Prefrontal Cortex; Pyridines; Rats | 2015 |
Tolerance to the antinociceptive effects of chronic morphine requires c-Jun N-terminal kinase.
Topics: Analgesics; Animals; Anthracenes; Cisplatin; Drug Tolerance; Fentanyl; Formaldehyde; Hyperalgesia; Hypothermia, Induced; JNK Mitogen-Activated Protein Kinases; Mice, Inbred C57BL; Models, Biological; Morphine; Nociception; Protein Kinase Inhibitors | 2015 |
Role of the thalamic submedius nucleus histamine H1 and H 2 and opioid receptors in modulation of formalin-induced orofacial pain in rats.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Facial Pain; Formaldehyde; Histamine Agonists; Histamine Antagonists; Male; Morphine; Naloxone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Histamine H1; Receptors, Histamine H2; Receptors, Opioid; Thalamic Nuclei | 2015 |
Pharmacological modulation of neuropathic pain-related depression of behavior: effects of morphine, ketoprofen, bupropion and [INCREMENT]9-tetrahydrocannabinol on formalin-induced depression of intracranial self-stimulation in rats.
Topics: Analgesics; Analgesics, Opioid; Animals; Bupropion; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Electric Stimulation; Formaldehyde; Hyperalgesia; Ketoprofen; Male; Medial Forebrain Bundle; Morphine; Neuralgia; Rats; Rats, Sprague-Dawley; Self Stimulation | 2016 |
Effects of intrathecal amylin on formalin-induced nociception and on cAMP accumulation in the rat embryonic spinal cells.
Topics: Amylin Receptor Agonists; Analgesics; Analgesics, Opioid; Animals; Calcitonin Gene-Related Peptide; Cyclic AMP; Formaldehyde; Inflammation; Injections, Spinal; Islet Amyloid Polypeptide; Male; Morphine; Naloxone; Narcotic Antagonists; Nociception; Pain; Pain Threshold; Peptide Fragments; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Receptors, Islet Amyloid Polypeptide; Spinal Cord | 2016 |
Concurrent bullatine A enhances morphine antinociception and inhibits morphine antinociceptive tolerance by indirect activation of spinal κ-opioid receptors.
Topics: Alkaloids; Analgesics; Animals; Behavior, Animal; Diterpenes; Dose-Response Relationship, Drug; Drug Combinations; Drug Tolerance; Dynorphins; Formaldehyde; Hot Temperature; Hyperalgesia; Male; Mice; Microglia; Morphine; Pain; Rats, Wistar; Receptors, Opioid, kappa; Spine | 2017 |
Dissociation of morphine analgesic effects in the sensory and affective components of formalin-induced spontaneous pain in male and female rats.
Topics: Affect; Analgesics, Opioid; Animals; Avoidance Learning; Conditioning, Psychological; Dose-Response Relationship, Drug; Female; Formaldehyde; Immunohistochemistry; Lumbar Vertebrae; Male; Morphine; Pain; Pain Measurement; Pain Perception; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats, Sprague-Dawley; Sex Characteristics; Spatial Behavior | 2017 |
Formalin injection produces long-lasting hypersensitivity with characteristics of neuropathic pain.
Topics: Activating Transcription Factor 3; Amines; Animals; Cyclohexanecarboxylic Acids; Female; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Ganglia, Spinal; Gene Expression Regulation; Indomethacin; Injections; Ligation; Morphine; Neuralgia; Rats; Time Factors | 2017 |
Effects of luteolin and luteolin-morphine co-administration on acute and chronic pain and sciatic nerve ligated-induced neuropathy in mice.
Topics: Acute Disease; Analgesics; Animals; Chronic Pain; Disease Models, Animal; Drug Therapy, Combination; Formaldehyde; Herb-Drug Interactions; Hot Temperature; Luteolin; Mice; Morphine; Nociceptive Pain; Pain; Pain Management; Peripheral Nerve Injuries; Phytotherapy; Plant Extracts; Sciatic Nerve; Sciatic Neuropathy; Sciatica | 2017 |
Adult Zebrafish (Danio rerio): An Alternative Behavioral Model of Formalin-Induced Nociception.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Disease Models, Animal; Formaldehyde; Indomethacin; Locomotion; Morphine; Nociception; Zebrafish | 2017 |
A Neural Circuit for the Suppression of Pain by a Competing Need State.
Topics: Agouti-Related Protein; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Diet; Feeding Behavior; Formaldehyde; Glutamate Decarboxylase; Locomotion; Mice; Mice, Inbred C57BL; Morphine; Neurons; Pain; Parabrachial Nucleus; Receptors, Neuropeptide Y; Signal Transduction | 2018 |
Opioid-sparing effects of cannabinoids on morphine analgesia: participation of CB
Topics: Analgesics, Opioid; Animals; Cannabinoids; Carrageenan; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Morphine; Pain; Pain Management; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Structure-Activity Relationship | 2019 |
Spinal administration of the multi-functional opioid/neuropeptide FF agonist BN-9 produced potent antinociception without development of tolerance and opioid-induced hyperalgesia.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Drug Tolerance; Fascia; Formaldehyde; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; Mice; Morphine; Oligopeptides; Pain; Rats, Wistar | 2020 |
Repeated Administration of Baclofen Modulates TRPV-1 Channel Expression by PKC Pathway in Dorsal Root Ganglia of Spinal Cord in a Morphine Tolerance Model of Rats
Topics: Animals; Baclofen; Disease Models, Animal; Formaldehyde; Ganglia, Spinal; Gene Expression Regulation; Male; Morphine; Protein Kinase C; Rats, Wistar; RNA, Messenger; Spinal Cord; TRPV Cation Channels | 2020 |
Antinociceptive, anti-inflammatory and antioxidant activities of the crude ethanolic extract and alkaloid fraction of Waltheria viscosissima A. St. - Hil. (Malvaceae).
Topics: Alkaloids; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Dexamethasone; Edema; Ethanol; Formaldehyde; Inflammation; Male; Malvaceae; Mice; Morphine; Pain; Plant Extracts | 2022 |
Adolescent nicotine exposure increases nociceptive behaviors in rat model of formalin test: Involvement of ventrolateral periaqueductal gray neurons.
Topics: Analgesics; Animals; Formaldehyde; Male; Morphine; Neurons; Nicotine; Nociception; Pain; Pain Measurement; Periaqueductal Gray; Rats; Rats, Wistar | 2022 |
Detection of delta F508 cystic fibrosis mutation by polymerase chain reaction from old paraffin-embedded tissues: a retrospective autopsy study.
Topics: Base Sequence; Cystic Fibrosis; DNA Mutational Analysis; DNA Primers; Electrophoresis, Agar Gel; Formaldehyde; Humans; Infant, Newborn; Meconium; Molecular Sequence Data; Mutation; Paraffin Embedding; Polymerase Chain Reaction; Retrospective Studies; Tissue Fixation | 1994 |