formaldehyde has been researched along with capsaicin in 157 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (4.46) | 18.7374 |
| 1990's | 27 (17.20) | 18.2507 |
| 2000's | 53 (33.76) | 29.6817 |
| 2010's | 63 (40.13) | 24.3611 |
| 2020's | 7 (4.46) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Arvier, PT; Chahl, LA; Ladd, RJ | 1 |
| Boccalini, P; Moskowitz, MA; Nozaki, K | 1 |
| Cowan, A; Wheeler-Aceto, H | 1 |
| Inoki, R; Ohkubo, T; Shibata, M; Takahashi, H | 2 |
| Ferrell, WR; Lam, FY | 1 |
| Dickenson, A; Dray, A | 1 |
| Andoh, R; Fujii, T; Kisara, K; Sakurada, S; Sasaki, T; Tanno, K; Yabuta, M; Yamaguchi, K | 1 |
| Kruger, L; Rodin, BE | 1 |
| Abbott, FV; Grimes, RW; Melzack, R | 1 |
| Kantner, RM; Kirby, ML | 1 |
| Hayes, AG; Skingle, M; Tyers, MB | 1 |
| Greskötter, KR; Mayer, B; Neuhuber, WL; Wiesand, M; Wörl, J | 1 |
| Hayashi, K; Kuraishi, Y; Nagasawa, T; Satoh, M | 1 |
| Katsumata, K; Kisara, K; Sakurada, S; Sakurada, T; Tan-No, K; Yogo, H | 1 |
| Katsumata, K; Kisara, K; Manome, Y; Ohba, M; Sakurada, S; Sakurada, T; Tan-No, K | 1 |
| Ohkubo, T; Shibata, M; Takahashi, H | 1 |
| Bian, RL; Chen, LP; Wang, YC; Wei, EQ; Xin, XH; Zhang, LF | 1 |
| Fang, Y; Han, JS; Ji, RR; Zhang, M | 1 |
| Kisara, K; Sakurada, C; Sakurada, S; Sakurada, T; Sugiyama, A; Tan-No, K; Yonezawa, A | 1 |
| Calcutt, NA; Hua, XY; Malmberg, AB | 1 |
| Calixto, JB; Santos, AR | 2 |
| Mansikka, H; Pertovaara, A | 1 |
| Beirith, A; Calixto, JB; Creczynski-Pasa, TB; Rodrigues, AL; Santos, AR | 1 |
| Calixto, JB; Campos, MM; Cechinel Filho, V; Mendes, GL; Santos, AR; Tratsk, KS; Yunes, RA | 1 |
| De Freitas, GA; Santos, AR; Vedana, EM | 1 |
| Calixto, JB; Miguel, OG; Santos, AR; Yunes, RA | 1 |
| Damas, J; Liégeois, JF | 1 |
| Kamei, J; Kashiwazaki, T; Nagase, H; Ohsawa, M | 1 |
| Calixto, JB; Ferreira, J; Santos, AR | 1 |
| Alves, RV; Calixto, JB; Chakravarty, S; de Campos, RO; Ferreira, J; Kyle, DJ; Mavunkel, BJ | 1 |
| Baba, H; Brenner, GJ; Ji, RR; Woolf, CJ | 1 |
| Inoue, K; Tsuda, M; Ueno, S | 1 |
| Calixto, JB; Filho, VC; Malheiros, A; Mendes, GL; Santos, AR; Yunes, RA | 1 |
| Calixto, JB; Delle Monache, F; Ferreira, J; Filho, VC; Floriani, AE; Santos, AR; Yunes, RA | 1 |
| Hashimoto, Y; Katsuyama, S; Kuramasu, A; Kutsuwa, M; Lin, ZY; Mobarakeh, JI; Sakurada, S; Watanabe, T; Yanai, K | 1 |
| He, YF; Ichikawa, H; Sugimoto, T | 1 |
| Cechinel-Filho, V; De Jesus, RA; Oliveira, AE; Schlemper, V | 1 |
| Regoli, D | 1 |
| Calixto, JB; De Campos, RO; Filho, VC; Miguel, OG; Santos, AR; Siani, AC; Yunes, RA | 1 |
| Calixto, JB; Cechinel Filho, V; Luzzi, R; Niero, R; Roos, JF; Santos, AR; Scheidt, C; Yunes, RA | 1 |
| Changeux, JP; Damaj, MI; Epping-Jordan, MP; Marubio, LM; Merlo-Pich, E; Salmon, AM | 1 |
| Choi, SS; Chung, KM; Lee, KC; Suh, HW | 1 |
| Liu, XJ; Sawynok, J; White, TD | 1 |
| Carstens, E; Jinks, SL | 1 |
| Chidiac, JJ; Hawwa, NN; Jabbur, SJ; Jurjus, AR; Massaad, CA; Rifai, K; Saadé, NE | 1 |
| Cechinel-Filho, V; Corrêa, R; de Campos, F; de Souza, MM; Nunes, RJ; Yunes, RA | 1 |
| Calixto, JB; Ferreira, J; Santos, AR; Trentin, AP; Yunes, RA | 1 |
| Jung, EA; Nogueira, CW; Quinhones, EB; Rocha, JB; Zeni, G | 1 |
| Kashiba, H; Nishigori, A; Ohshima, M; Ohshiro, M; Takeda, D; Uchida, Y; Ueda, Y | 1 |
| Carlton, SM; Coggeshall, RE; Kraemer, B; Zhou, S | 1 |
| Choi, SS; Han, EJ; Han, KJ; Lee, HK; Suh, HW | 1 |
| Alexandre-Moreira, MS; Barreiro, EJ; Bolzani, Vda S; Palhares de Miranda, AL; Viegas, C | 1 |
| Abdel-Salam, OM; Arbid, MS; Baiuomy, AR; El-batran, S | 1 |
| Dussor, GO; Flores, CM; Hargreaves, KM; Helesic, G | 1 |
| Ko, S; Qiu, CS; Toyoda, H; Zhao, MG; Zhuo, M | 1 |
| El Kouhen, R; Faltynek, CR; Gauvin, DM; Gomtsyan, A; Honore, P; Jarvis, MF; Lee, CH; Marsh, K; Mikusa, J; Sullivan, JP; Wismer, CT; Zhong, C; Zhu, CZ | 1 |
| Angers, P; Dalbó, S; Jürgensen, S; Ribeiro-do-Valle, RM; Santos, AR | 1 |
| Kato, M; Kuramasu, A; Mobarakeh, JI; Orito, T; Sakurada, S; Sakurai, E; Yanai, K; Yoshida, A | 1 |
| Facundo, VA; Marques, MC; Pietrovski, EF; Rios, K; Rosa, KA; Santos, AR | 1 |
| Beltramo, M; Bernardini, N; Bertorelli, R; Campanella, M; Fredduzzi, S; Nicolussi, E; Reggiani, A | 1 |
| Abdel-Salam, OM | 1 |
| Carlton, SM; Ji, GC; Jurczyk, S; Reubi, JC; Shapiro, G; Zhou, ST | 1 |
| DeHate, RB; Richards, IS | 1 |
| Beaulieu, P; De Léan, A; Guindon, J; LoVerme, J; Piomelli, D | 1 |
| Childeric, A; Dallel, R; Gaydier, AM; Luccarini, P; Voisin, D | 1 |
| Arendt-Nielsen, L; Chen, HS; He, X; Wang, Y; Wen, WW; You, HJ | 1 |
| Gyires, K; Helyes, Z; László, J; Sándor, K; Szolcsányi, J | 1 |
| Furue, H; Hasegawa, S; Inoue, K; Ishii, S; Koizumi, S; Masuda, T; Nagata, K; Nakamura, K; Shimizu, T; Tozaki-Saitoh, H; Tsuda, M; Yamashita, T; Yoshimura, M | 1 |
| Chen, YF; Jiao, YL; Li, N; Qin, LP; Rahman, K; Wei, P; Zhang, QY; Zheng, HC | 1 |
| de Arruda Veiga, MC; Fischer, L; Gameiro, GH; Tambeli, CH; Urtado, CB; Urtado, MB | 1 |
| Jesse, CR; Nogueira, CW; Pinto, LG; Savegnago, L | 1 |
| Chaves, MH; Cunha, GM; Guedes, MA; Holanda Pinto, SA; Pinto, LM; Rao, VS; Santos, FA | 1 |
| Ahmadi, S; Brockhaus, J; Brune, K; Fritschy, JM; Hess, A; Hösl, K; Knabl, J; Möhler, H; Reinold, H; Rudolph, U; Sergejeva, M; Witschi, R; Zeilhofer, HU; Zeilhofer, UB | 1 |
| Chen, YF; Li, N; Qin, LP; Rahman, K; Wu, JZ; Zhang, H; Zhang, QY; Zheng, HC | 1 |
| Cechinel Filho, V; de Souza, MM; Delle Monache, F; Delle Monache, G; Fischer, LG; Malheiros, A; Santos, D; Serafin, C | 1 |
| de Souza, MM; Filho, AW; Filho, VC; Olinger, L | 1 |
| Asanuma, T; Inanami, O; Kuwabara, M; Sato, M; Yasui, H | 1 |
| Futamura, M; Goto, S; Ito, K; Kimoto, I; Kimura, R; Miyake, M; Sakamoto, T | 1 |
| García-López, BE; Granados-Soto, V; Herrejon-Abreu, EB; López-Santillán, FJ; Murbartián, J; Rocha-González, HI | 1 |
| del Camino, D; Kerstein, PC; Moran, MM; Stucky, CL | 1 |
| Chen, YF; Huang, Y; Qin, LP; Tang, WZ; Zheng, HC | 1 |
| Bortolatto, CF; Jesse, CR; Nogueira, CW; Savegnago, L; Wilhelm, EA | 1 |
| Cechinel-Filho, V; Corrêa, R; de Campos-Buzzi, F; Delle Monache, F; Fracasso, M; Niero, R; Padaratz, P | 1 |
| Chen, J; Cui, XY; DU, YR; Lv, ZM; Tian, LJ; Xiao, Y; Yu, YQ | 1 |
| Ito, K; Miyake, M; Muto, T; Ohshima, M; Sakamoto, T; Takeda, M; Ueda, N | 1 |
| Alexandre-Moreira, MS; Barbosa-Filho, JM; Chaves, MC; da Silva, DJ; de Aquino, AB; de Araújo-Júnior, JX; de Athayde-Filho, PF; de Lira, DP; de Miranda, GE; de Queiroz, AC; de Souza, ET; Lorenzo, VP; Mella, EA; Santos, BV | 1 |
| Almeida, FR; Chaves, MH; Costa, DA; Figueiredo, KA; Lopes, LS; Marques, RB; Pereira, SS | 1 |
| Basbaum, AI; Bráz, JM | 1 |
| Almeida, JR; Araujo, AA; Araújo, DA; Bonjardim, LR; De Sousa, DP; Gelain, DP; Gonçalves, JC; Melo, MS; Onofre, AC; Quintans-Júnior, LJ | 1 |
| Duraku, LS; Holstege, JC; Hossaini, M; Jongen, JLM; Saraç, Ç | 1 |
| Antoniolli, AR; Araújo, AA; Bonjardim, LR; Cavalcanti, SC; Gelain, DP; Guimarães, AG; Melo, MS; Moreira, JC; Oliveira, GF; Quintans-Júnior, LJ; Rocha, RF; Santos, JP; Silva, FA | 1 |
| Ballard, CJ; Hurley, JH; Kunkler, PE; Oxford, GS | 1 |
| Basbaum, AI; Edwards, RH; Harper, B; Hnasko, TS; Low, SA; Scherrer, G; Solorzano, C; Urban, R; Wang, X; Yamanaka, H; Zhang, J | 1 |
| Chapman, H; Hao, B; Huang, JL; Koivisto, A; Kuokkanen, K; Pertovaara, A; Saarnilehto, M; Wang, YX; Wei, H | 1 |
| Carlton, SM; Du, J; Govea, R; Zhou, S | 1 |
| Beaudry, H; Dubois, D; Gendron, L | 1 |
| Akasaka, Y; Hatta, A; Inoue, H; Sakai, A; Suzuki, H; Takasu, K; Tsukahara, M | 1 |
| Alvarez, P; Brun, A; Constandil, L; Correa, A; Hernández, A; Labertrandie, A; Lopez, J; Pelissier, T | 1 |
| Endo, T; Inagaki, N; Nagai, H; Saito, A; Shimouchi, A; Tanaka, H; Tominaga, M; Usuda, H; Yamashita, H | 1 |
| Dyhr, H; Erichsen, HK; Hansen, MK; Marcher, L; Munro, G; Sheykhzade, M; Storm, A | 1 |
| Bum, EN; Dawe, A; De Waard, M; Dimo, T; Dzeufiet, PD; Nguimbou, RM; Sidiki, N; Taïwe, GS; Talla, E | 1 |
| Baeyens, JM; Bura, A; Burgueño, J; Codony, X; Dordal, A; Encina, G; Escriche, M; Giraldo, J; Hernández, E; Laloya, M; López-García, JA; Maldonado, R; Merlos, M; Montero, A; Muro, A; Nadal, X; Plata-Salamán, CR; Portillo-Salido, E; Rivera-Arconada, I; Romero, L; Sánchez-Arroyos, R; Segalés, C; Vela, JM; Zamanillo, D | 1 |
| Bagetta, G; Mizoguchi, H; Sakurada, S; Watanabe, C | 1 |
| Cunha, JM; Jesus, CH; Neufeld, M; Schreiber, AK | 1 |
| Fereidoni, M; Niazmand, S; Sepehri, Z | 1 |
| Araújo, BS; Damascena, NP; de Lima, AC; de Santana, MT; Dias, AS; dos S Estevam, C; Fernandes, XA; Lima, CA; Melo, M; Paixão, MS; Porto, YC; Quintans Júnior, LJ; Santos, CC | 1 |
| Almeida, FR; Brandão, MS; Chaves, MH; Ferreira, EL; Lima, DF; Oliveira, JP; Pereira, SS | 1 |
| Cechinel Filho, V; de Campos Buzzi, F; Klein-Júnior, LC; Moreira, J | 1 |
| Chen, PX; Guo, HM; Huang, JH; Luo, YL; Zhang, YL; Zhou, WL; Zhu, YX | 1 |
| Bjerrum, OJ; Dalbøge, LS; Dupont, E; Heegaard, AM; Jensen, TS; Larsen, M; Møller, AT; Møller, LB; Nasser, A | 1 |
| Deshpande, SS; Jain, MR; Patel, RB; Pawar, VD; Prajapati, KD; Shah, GB; Sonara, BM | 1 |
| Chen, R; Lai, K; Li, J; Li, L; Liu, X; Ma, P; Wu, Y; Yang, X; Yao, H; Ye, X; You, H; Yuan, Y | 1 |
| Déciga-Campos, M; González-Trujano, ME; Pellicer, F; Ventura-Martínez, R; Verano, J | 1 |
| Cervantes-Durán, C; Espinosa de los Monteros-Zuñiga, A; Godínez-Chaparro, B; Izquierdo, T; Lozada, MC | 1 |
| Baggio, CH; Cipriani, TR; da Silva, CF; de Souza, LM; Hamm, LA; Nascimento, AM; Nomura, EC; Rodrigues, MR; Werner, MF | 1 |
| Alves, PB; Araújo, AA; Bonjardim, LR; de Lucca Júnior, W; Lucchese, AM; Menezes, PP; Quintans, JS; Quintans-Júnior, LJ; Santos, MR; Siqueira-Lima, PS | 1 |
| Duraku, LS; Holstege, JC; Hossaini, M; Jongen, JL; Kohli, SK | 1 |
| Almeida, FR; Amaral, MP; Chaves, MH; Costa, DA; Figueiredo, KA; Júnior, FB; Oliveira, FA; Oliveira, IS; Oliveira, RC; Silva, FV | 1 |
| Alexandre-Moreira, MS; Alves, Hda S; Campesatto, EA; Cavalcante-Silva, LH; Chaves, MC; de Queiroz, AC; Dias, Tde L; Melo, GM; Santos, Mda S | 1 |
| Boylan, F; Dias Fernandes, P; Miltojević, AB; Pinheiro, MM; Radulović, NS | 1 |
| Chichorro, JG; Cruz, LS; Kopruszinski, CM | 1 |
| Cai, J; Guo, J; Liu, FY; Sun, WL; Wan, Y; Xing, GG; Yang, F | 1 |
| Ganev, EG; Hiruma-Lima, CA; Martins, DF; Mazzardo-Martins, L; Nishijima, CM; Rocha, LR; Santos, AR | 1 |
| Barragán-Iglesias, P; Granados-Soto, V; Martínez-Rojas, VA; Murbartián, J; Rocha-González, HI | 1 |
| Filipek, B; Sałat, K | 1 |
| Wan, Y | 1 |
| Charrua, A; Di Marzo, V; Martins, D; Morgado, C; Piscitelli, F; Silva, M; Tavares, I | 1 |
| Awouafack, MD; Kamanyi, A; Nguelefack, TB; Nkeng-Efouet, PA; Tatsinkou Bomba, FD; Wandji, BA | 1 |
| Bradshaw, H; Carey, LM; Cornett, B; Hohmann, AG; Leishman, E; Mackie, K; Slivicki, RA | 1 |
| Amorim, RM; Assreuy, AM; Cajazeiras, JB; Cavada, BS; do Nascimento, KS; Dos Santos-Nascimento, T; Leal-Cardoso, JH; Mota, MR; Pires, AF | 1 |
| Aktumsek, A; Amarante, RKL; Amarante, RS; Barreto, AS; Barreto, RSS; Coutinho, HDM; Duarte, MC; Menezes, IRA; Nascimento, TS; Pereira, EWM; Quintans, JSS; Quintans-Júnior, LJ; Zengin, G | 1 |
| Kaur, CD; Mazumder, B; Sarwa, KK; Suresh, PK | 1 |
| Athayde, ML; Boligon, AA; Brandão, R; Carvalho, FB; da Rosa Moreira, L; da Silva Brum, E; da Silva, ARH; Oliveira, SM | 1 |
| Géranton, SM; Hunt, SP; Maiarú, M; Norris, C; Tochiki, KK | 1 |
| Abbasnejad, M; Bahaaddini, M; Esmaeili-Mahani, S; Khatamsaz, S; Raoof, M | 1 |
| Baeyens, JM; Cervero, F; Cobos, EJ; Coderre, TJ; Gonzalez-Cano, R; Lehmann, M; Pitcher, MH; Vincent, K | 1 |
| Braga, RM; de Almeida, RN; de Castro, RD; de Sousa, DP; de Sousa, FB; deM Pordeus, LC; Tomaz-Morais, JF | 1 |
| Borges, MH; Cordeiro, MN; de Castro Junior, CJ; de Oliveira Adamante, G; De Prá, SD; de Souza, AH; Ferreira, J; Gomez, MV; Milioli, AM; Rigo, FK; Santa Cecilia, FV; Silva, JF; Trevisan, G | 1 |
| Hashimoto, H; Kawasaki, M; Maruyama, T; Matsuura, T; Motojima, Y; Ohnishi, H; Saito, R; Sakai, A; Sonoda, S; Suzuki, H; Ueno, H; Ueta, Y; Yoshimura, M | 1 |
| Back, SK; Han, RT; Kim, HJ; Kim, HY; Lee, J; Na, HS | 1 |
| Aurelio, L; Bunnett, NW; Cai, Z; Canals, M; Christie, MJ; Geppetti, P; Halls, ML; Hicks, GA; Imlach, WL; Jensen, DD; Klein Herenbrink, C; Lieu, T; McLean, P; Poole, DP; Porter, CJH; Veldhuis, NA; Yarwood, RE | 1 |
| Fernandes, PD; Giorno, TBS; Moreira, IGDS; Rezende, CM | 1 |
| Andrade Próspero, DF; de Castro Almeida, FR; de Sousa, DP; Lopes, EM; Piauilino, CA; Reis Filho, AC | 1 |
| Alves, YA; Campos, AR; Coelho, RF; Magalhaes, FEA; Santos, SAAR; Soares, ICR; Tavares, KCS; Vieira-Neto, AE | 1 |
| Kravchenko, I; Nesterkina, M | 1 |
| Barragán-Iglesias, P; Flores-Murrieta, FJ; Granados-Soto, V; Huerta-Cruz, JC; Pineda-Farias, JB; Quiñonez-Bastidas, GN; Reyes-García, JG; Roa-Coria, JE; Rocha-González, HI; Zúñiga-Romero, Á | 1 |
| Araya, EI; Chichorro, JG; Claudino, RF; de Oliveira, SB; Ferreira, LEN; Franz-Montan, M; Gambeta, E | 1 |
| Belboukhari, N; Cheriti, A; Ould El Hadj-Khelil, A; Seddiki, LS; Sekkoum, K; Sulaiman, MR | 1 |
| Lei, F; Yan, Z | 1 |
| Guan, L; Li, J; Zhang, X | 1 |
| Liu, J; Ma, F; Shen, Z; Tan, J; Wu, Y; Yu, J; Zhuang, J | 1 |
| Abelson, KSP; Kanui, TI; Makau, CM; Towett, PK | 1 |
| Abbasnejad, M; Esmaeili-Mahani, S; Kooshki, R; Lobbezoo, F; Raoof, M; Tajabadi, A | 1 |
| Guo, J; Song, Y; Tang, J; Tang, Z; Yang, Y; Yu, G; Zhu, C | 1 |
2 review(s) available for formaldehyde and capsaicin
| Article | Year |
|---|---|
Deafferentation in animals as a model for the study of pain: an alternative hypothesis.
Topics: Afferent Pathways; Animals; Capsaicin; Denervation; Disease Models, Animal; Formaldehyde; Hydroxydopamines; Neurons, Afferent; Oxidopamine; Pain; Rats; Reptiles; Species Specificity; Spinal Nerve Roots; Spinal Nerves; Tail | 1984 |
New Mechanism of Bone Cancer Pain: Tumor Tissue-Derived Endogenous Formaldehyde Induced Bone Cancer Pain via TRPV1 Activation.
Topics: Animals; Bone Neoplasms; Cancer Pain; Capsaicin; Cells, Cultured; Formaldehyde; Glycine Hydroxymethyltransferase; Histone Demethylases; Humans; Insulin-Like Growth Factor I; Mammary Neoplasms, Experimental; Neoplasm Proteins; Osteoblasts; Peripheral Nerves; Podophyllotoxin; Protein Kinase Inhibitors; Signal Transduction; TRPV Cation Channels | 2016 |
2 trial(s) available for formaldehyde and capsaicin
| Article | Year |
|---|---|
Topical Analgesic Nanolipid Vesicles Formulation of Capsaicinoids Extract of Bhut Jolokia (Capsicum chinense Jacq): Pharmacodynamic Evaluation in Rat Models and Acceptability studies in Human Volunteers.
Topics: Administration, Topical; Analgesics; Animals; Arthritis, Experimental; Capsaicin; Capsicum; Carrageenan; Drug Carriers; Formaldehyde; Freund's Adjuvant; Healthy Volunteers; Humans; In Vitro Techniques; Inflammation; Male; Nanoparticles; Phosphatidylcholines; Phytotherapy; Plant Extracts; Rats, Wistar; Skin; Skin Absorption | 2016 |
Orofacial antinociceptive activity of (S)-(-)-perillyl alcohol in mice: a randomized, controlled and triple-blind study.
Topics: Animals; Capsaicin; Facial Pain; Formaldehyde; Glutamic Acid; Male; Mice; Monoterpenes; Morphine; Pain Measurement | 2017 |
153 other study(ies) available for formaldehyde and capsaicin
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Modification by capsaicin and compound 48/80 of dye leakage induced by irritants in the rat.
Topics: Adenosine Triphosphate; Animals; Azo Compounds; Bradykinin; Capsaicin; Edema; Evans Blue; Fatty Acids, Unsaturated; Formaldehyde; Histamine; Hydrochloric Acid; Male; Models, Biological; p-Methoxy-N-methylphenethylamine; Potassium Chloride; Prostaglandins E; Rats; Serotonin; Skin | 1977 |
CP-93,129, sumatriptan, dihydroergotamine block c-fos expression within rat trigeminal nucleus caudalis caused by chemical stimulation of the meninges.
Topics: Animals; Animals, Newborn; Capsaicin; Carrageenan; Dihydroergotamine; Formaldehyde; Gene Expression Regulation, Neoplastic; Guinea Pigs; Immunohistochemistry; In Vitro Techniques; Indoles; Meninges; Nasal Mucosa; Proto-Oncogene Proteins c-fos; Pyridines; Pyrroles; Rats; Sulfonamides; Sumatriptan | 1992 |
Neurogenic and tissue-mediated components of formalin-induced edema: evidence for supraspinal regulation.
Topics: Animals; Axons; Capsaicin; Denervation; Down-Regulation; Edema; Foot; Formaldehyde; Male; Nerve Block; Nervous System; Neurons, Afferent; Peripheral Nerves; Rats; Rats, Inbred Strains; Spinal Cord; Synaptic Transmission | 1991 |
Roles of substance P and somatostatin on transmission of nociceptive information induced by formalin in spinal cord.
Topics: Animals; Capsaicin; Cysteamine; Drug Interactions; Formaldehyde; Mice; Pain; Pain Measurement; Somatostatin; Spinal Cord; Substance P; Synaptic Transmission | 1990 |
Neurogenic component of different models of acute inflammation in the rat knee joint.
Topics: Animals; Capsaicin; Carrageenan; Disease Models, Animal; Formaldehyde; Hindlimb; Inflammation; Joints; Male; p-Methoxy-N-methylphenethylamine; Rats; Rats, Inbred Strains; Substance P; Uric Acid | 1991 |
Systemic capsaicin and olvanil reduce the acute algogenic and the late inflammatory phase following formalin injection into rodent paw.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Electrophysiology; Foot; Formaldehyde; Indomethacin; Inflammation; Mice; Morphine; Neurons; Pain; Spinal Cord | 1991 |
Modified formalin test: characteristic biphasic pain response.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Bromelains; Capsaicin; Dexamethasone; Dose-Response Relationship, Drug; Formaldehyde; Indomethacin; Male; Mice; Morphine; Nerve Fibers; p-Methoxy-N-methylphenethylamine; Pain; Pain Measurement; Sciatic Nerve; Substance P; Time Factors | 1989 |
[The effect of nonanoyl vanillylamide on the chemically-induced nociception].
Topics: Analgesics; Animals; Benzoquinones; Capsaicin; Dose-Response Relationship, Drug; Formaldehyde; Hydroxybenzoates; Injections, Subcutaneous; Male; Mice; Pain Measurement; Quinones; Stimulation, Chemical; Vanillic Acid | 1987 |
Single nerve capsaicin: effects on pain and morphine analgesia in the formalin and foot-flick tests.
Topics: Analgesia; Animals; Capsaicin; Formaldehyde; Male; Morphine; Pain; Peripheral Nerves; Rats; Sciatic Nerve; Time Factors | 1984 |
Changes in acid phosphatase activity in the substantia gelatinosa in response to pain.
Topics: Acid Phosphatase; Animals; Animals, Newborn; Capsaicin; Female; Forelimb; Formaldehyde; Nociceptors; Pregnancy; Rats; Rats, Inbred Strains; Spinal Cord; Substantia Gelatinosa | 1982 |
Effects of single doses of capsaicin on nociceptive thresholds in the rodent.
Topics: Acetylcholine; Animals; Capsaicin; Fatty Acids, Unsaturated; Formaldehyde; Hot Temperature; Male; Mice; Mice, Inbred Strains; Nociceptors; Pain | 1981 |
Neuronal and endothelial nitric oxide synthase immunoreactivity and NADPH-diaphorase staining in rat and human pancreas: influence of fixation.
Topics: Acetone; Amino Acid Oxidoreductases; Amino Acid Sequence; Animals; Capsaicin; Cryoultramicrotomy; Endothelium; Female; Formaldehyde; Ganglia; Glutaral; Histocytochemistry; Humans; Immunohistochemistry; Islets of Langerhans; Male; Molecular Sequence Data; NADPH Dehydrogenase; Neurons; Nitric Oxide Synthase; Pancreas; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Rats, Wistar; Staining and Labeling; Tissue Fixation | 1994 |
Scratching behavior induced by pruritogenic but not algesiogenic agents in mice.
Topics: Animals; Behavior, Animal; Capsaicin; Formaldehyde; Histamine; Male; Mice; p-Methoxy-N-methylphenethylamine; Pain; Pruritus; Substance P | 1995 |
Antinociception induced by CP 96,345, a non-peptide NK-1 receptor antagonist, in the mouse formalin and capsaicin tests.
Topics: Analgesics; Animals; Biphenyl Compounds; Capsaicin; Dose-Response Relationship, Drug; Formaldehyde; Hypnotics and Sedatives; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Naloxone; Pain; Pain Measurement; Postural Balance; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P | 1993 |
Antinociceptive effects in the formalin and capsaicin tests after intrathecal administration of substance P analogues in mice.
Topics: Analgesics; Animals; Capsaicin; Drug Interactions; Formaldehyde; Injections, Spinal; Male; Mice; Naloxone; Pain; Substance P | 1993 |
The analgesia induced by intrathecal injection of ruthenium red.
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Formaldehyde; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Nociceptors; Pain; Pain Measurement; Ruthenium Red; Substance P | 1993 |
[Inhibition of chemically induced microvascular leakage by ONO-1078, a leukotriene antagonist, in rat skin].
Topics: Animals; Capillary Permeability; Capsaicin; Chlorpheniramine; Chromones; Dexamethasone; Formaldehyde; Histamine Antagonists; Male; Microcirculation; Rats; Rats, Sprague-Dawley; Skin; SRS-A | 1995 |
Topical capsaicin treatment suppresses formalin-induced fos expression in rat spinal cord.
Topics: Animals; Capsaicin; Female; Formaldehyde; Gene Expression Regulation; Immunohistochemistry; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Sciatic Nerve; Spinal Cord | 1994 |
Effect of spinal nitric oxide inhibition on capsaicin-induced nociceptive response.
Topics: Animals; Arginine; Capsaicin; Formaldehyde; Injections, Intraperitoneal; Injections, Spinal; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nociceptors; Spinal Cord; Stereoisomerism | 1996 |
Neonatal capsaicin treatment abolishes formalin-induced spinal PGE2 release.
Topics: Amino Acids; Animals; Animals, Newborn; Capsaicin; Dinoprostone; Formaldehyde; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord | 1997 |
Further evidence for the involvement of tachykinin receptor subtypes in formalin and capsaicin models of pain in mice.
Topics: Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Drug Interactions; Formaldehyde; Injections, Intradermal; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Pain; Receptors, Tachykinin | 1997 |
Submodality-selective hyperalgesia adjacent to partially injured sciatic nerve in the rat is dependent on capsaicin-sensitive afferent fibers and independent of collateral sprouting or a dorsal root reflex.
Topics: Animals; Capsaicin; Extravasation of Diagnostic and Therapeutic Materials; Formaldehyde; Ganglia, Spinal; Hindlimb; Hot Temperature; Hyperalgesia; Immersion; Male; Mechanoreceptors; Nerve Fibers; Nerve Regeneration; Neuralgia; Neurites; Neurons, Afferent; Nociceptors; Physical Stimulation; Plasma; Rats; Rats, Wistar; Reflex; Sciatic Nerve | 1997 |
Ruthenium red and capsazepine antinociceptive effect in formalin and capsaicin models of pain in mice.
Topics: Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Formaldehyde; Injections, Intradermal; Injections, Intraventricular; Male; Mice; Naloxone; Pain; Ruthenium Red | 1997 |
Spinal and supraspinal antinociceptive action of dipyrone in formalin, capsaicin and glutamate tests. Study of the mechanism of action.
Topics: Analgesics, Non-Narcotic; Animals; Capsaicin; Dipyrone; Enzyme Inhibitors; Formaldehyde; Glutamic Acid; Hyperalgesia; Male; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pain; Pain Measurement; Postural Balance; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Spinal Cord | 1998 |
Anti-hyperalgesic properties of the extract and of the main sesquiterpene polygodial isolated from the barks of Drymis winteri (Winteraceae).
Topics: Abdominal Pain; Acetic Acid; Animals; Bradykinin; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Hyperalgesia; Male; Mice; Motor Activity; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Sesquiterpenes; Substance P; Zymosan | 1998 |
Antinociceptive effect of meloxicam, in neurogenic and inflammatory nociceptive models in mice.
Topics: Abdominal Muscles; Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Capsaicin; Cyclooxygenase Inhibitors; Diclofenac; Formaldehyde; Inflammation; Male; Meloxicam; Mice; Morphine; Muscle Contraction; Pain; Pain Measurement; Reaction Time; Thiazines; Thiazoles | 1998 |
Antinociceptive properties of the new alkaloid, cis-8, 10-di-N-propyllobelidiol hydrochloride dihydrate isolated from Siphocampylus verticillatus: evidence for the mechanism of action.
Topics: Abdominal Muscles; Acetic Acid; Alkaloids; Analgesics; Analgesics, Opioid; Animals; Capsaicin; Female; Formaldehyde; Gastrointestinal Transit; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Pain Measurement; Piperidines; Plants, Medicinal; Postural Balance; Reaction Time; Vas Deferens | 1999 |
The inflammatory reaction induced by formalin in the rat paw.
Topics: Anesthetics, Local; Animals; Blood Pressure; Bradykinin; Capillary Permeability; Capsaicin; Dose-Response Relationship, Drug; Edema; Extravasation of Diagnostic and Therapeutic Materials; Formaldehyde; Inflammation; Inflammation Mediators; Kininogens; Lidocaine; Male; Neuropeptides; Rats; Rats, Wistar; Serum Albumin; Time Factors | 1999 |
Antinociceptive effects of the ORL1 receptor agonist nociceptin/orphanin FQ in diabetic mice.
Topics: Animals; Capsaicin; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Formaldehyde; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Narcotic Antagonists; Nociceptin; Opioid Peptides; Pain | 1999 |
Antinociception produced by systemic, spinal and supraspinal administration of amiloride in mice.
Topics: Acetic Acid; Amiloride; Animals; Animals, Newborn; Behavior, Animal; Capsaicin; Disease Models, Animal; Diuretics; Dose-Response Relationship, Drug; Drug Administration Routes; Formaldehyde; Glutamic Acid; Hot Temperature; Hyperalgesia; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Male; Mice; Muscle Contraction; Pain; Pain Measurement; Postural Balance | 1999 |
Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Behavior, Animal; Bradykinin; Bradykinin Receptor Antagonists; Capsaicin; Carrageenan; Dinoprostone; Dipeptides; Dose-Response Relationship, Drug; Edema; Formaldehyde; Hindlimb; Hyperalgesia; Injections, Intraperitoneal; Male; Mice; Pain; Rats; Rats, Wistar; Receptor, Bradykinin B2; Time Factors | 1999 |
Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity.
Topics: Animals; Capsaicin; Enzyme Activation; Formaldehyde; Hindlimb; In Vitro Techniques; Male; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nociceptors; Pain; Pain Measurement; Pain Threshold; Phosphorylation; Posterior Horn Cells; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Temperature | 1999 |
Evidence for the involvement of spinal endogenous ATP and P2X receptors in nociceptive responses caused by formalin and capsaicin in mice.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Capsaicin; Formaldehyde; Male; Mice; Motor Activity; Nociceptors; Pain; Pain Measurement; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Receptors, Purinergic P2; Spinal Cord | 1999 |
Assessment of mechanisms involved in antinociception caused by sesquiterpene polygodial.
Topics: Adrenalectomy; Analgesics; Animals; Capsaicin; Drug Interactions; Formaldehyde; Glutamic Acid; Hyperalgesia; Male; Mice; Pain Measurement; Sesquiterpenes | 2000 |
Antinociceptive properties of the methanolic extract and two triterpenes isolated from Epidendrum Mosenii stems (Orchidaceae).
Topics: Acetic Acid; Analgesics; Animals; Capsaicin; Chromatography, Gas; Chromatography, Thin Layer; Dose-Response Relationship, Drug; Formaldehyde; Hot Temperature; Male; Methanol; Mice; Pain Measurement; Phytosterols; Plant Extracts; Plants, Medicinal; Postural Balance; Spectrophotometry, Infrared; Triterpenes | 2000 |
Role of histamine H(1) receptor in pain perception: a study of the receptor gene knockout mice.
Topics: Animals; Behavior, Animal; Capsaicin; Chlorpheniramine; Formaldehyde; Histamine H1 Antagonists; Hot Temperature; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Pyrilamine; Reaction Time; Receptors, Histamine H1; Reverse Transcriptase Polymerase Chain Reaction; Stereoisomerism | 2000 |
The effect of neonatal capsaicin on the c-Fos-like immunoreactivity induced in subnucleus oralis neurons by noxious intraoral stimulation.
Topics: Animals; Animals, Newborn; Calcitonin Gene-Related Peptide; Capsaicin; Dental Pulp; Electric Stimulation; Female; Formaldehyde; Gene Expression Regulation; Genes, fos; Genes, Immediate-Early; Immediate-Early Proteins; Male; Mouth Mucosa; Nerve Tissue Proteins; Neurons, Afferent; Nociceptors; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Trigeminal Ganglion | 2000 |
Analysis of the antinociceptive properties of marrubiin isolated from Marrubium vulgare.
Topics: Abdominal Pain; Acetic Acid; Analgesics; Animals; Brazil; Capsaicin; Diterpenes; Female; Formaldehyde; Male; Medicine, Traditional; Mice; Pain; Plants, Medicinal | 2000 |
Toward a new anti-inflammatory and analgesic agent.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Bradykinin Receptor Antagonists; Capsaicin; Cyclooxygenase 2; Formaldehyde; Inflammation; Interleukin-1; Isoenzymes; Mice; Mice, Knockout; Pain; Prostaglandin-Endoperoxide Synthases; Receptor, Bradykinin B1; Receptors, Bradykinin; Receptors, Neurokinin-1; Shock, Septic | 2000 |
Antinociceptive properties of extracts of new species of plants of the genus Phyllanthus (Euphorbiaceae).
Topics: Abdomen; Acetic Acid; Analgesics; Animals; Behavior, Animal; Brazil; Capsaicin; Euphorbiaceae; Formaldehyde; Male; Mice; Muscle Contraction; Pain; Pain Measurement; Plant Extracts; Plants, Medicinal | 2000 |
Antinociceptive activity of a hydroalcoholic extract obtained from aerial parts of Sebastiania schottiana (Euphorbiaceae).
Topics: Acetates; Analgesics; Animals; Capsaicin; Euphorbiaceae; Formaldehyde; Mice; Pain; Pain Measurement; Plant Extracts; Plant Leaves; Plant Stems | 2000 |
Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in alpha CGRP-deficient mice.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Carrageenan; Fixatives; Formaldehyde; Ganglionic Stimulants; Inflammation; Magnesium Sulfate; Mice; Mice, Transgenic; Morphine; Naloxone; Narcotic Antagonists; Nicotine; Opioid-Related Disorders; Pain; Substance Withdrawal Syndrome | 2001 |
Differential roles of spinal cholera toxin- and pertussis toxin-sensitive G proteins in nociceptive responses caused by formalin, capsaicin, and substance P in mice.
Topics: Animals; Behavior, Animal; Capsaicin; Cholera Toxin; Dose-Response Relationship, Drug; Drug Interactions; Formaldehyde; GTP-Binding Proteins; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Neurons; Nociceptors; Pain; Pain Measurement; Pain Threshold; Pertussis Toxin; Spinal Cord; Substance P; Synaptic Transmission; Virulence Factors, Bordetella | 2001 |
Intraplantar injection of glutamate evokes peripheral adenosine release in the rat hind paw: involvement of peripheral ionotropic glutamate receptors and capsaicin-sensitive sensory afferents.
Topics: Adenosine; Animals; Capsaicin; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Feedback, Physiological; Formaldehyde; Glutamic Acid; Hindlimb; Injections, Subcutaneous; Male; Microdialysis; Neurons, Afferent; Oxidopamine; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Skin | 2002 |
Responses of superficial dorsal horn neurons to intradermal serotonin and other irritants: comparison with scratching behavior.
Topics: Animals; Behavior, Animal; Capsaicin; Disinfectants; Electrophysiology; Formaldehyde; Histamine; Injections, Intradermal; Irritants; Male; Pain; Posterior Horn Cells; Pruritus; Rats; Rats, Sprague-Dawley; Serotonin | 2002 |
Nociceptive behaviour induced by dental application of irritants to rat incisors: a new model for tooth inflammatory pain.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Crowns; Cyclooxygenase Inhibitors; Dental Pulp Cavity; Disease Models, Animal; Drug Interactions; Female; Formaldehyde; Gingiva; Inflammation; Male; Meloxicam; Morphine; Naloxone; Narcotic Antagonists; Nerve Fibers; Nociceptors; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiazines; Thiazoles; Toothache | 2002 |
Studies on new cyclic imides obtained from aminophenazone with analgesic properties. Potent effects of a 3,4-dichloromaleimide derivative.
Topics: Acetic Acid; Aminopyrine; Analgesics, Non-Narcotic; Animals; Capsaicin; Formaldehyde; Imides; Indicators and Reagents; Male; Mice; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Peritonitis; Reaction Time; Structure-Activity Relationship | 2002 |
Mechanisms involved in the antinociception caused by compound MV8612 isolated from Mandevilla velutina in mice.
Topics: Analgesics; Animals; Apamin; Bradykinin; Capsaicin; Charybdotoxin; Formaldehyde; Glyburide; Glycosides; GTP-Binding Proteins; Hot Temperature; Hyperalgesia; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Pain; Pertussis Toxin; Potassium Channel Blockers; Potassium Channels; Steroids; Tetraethylammonium | 2003 |
Anti-inflammatory and antinociceptive activity of diphenyl diselenide.
Topics: Abdominal Muscles; Acetic Acid; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Azoles; Benzene Derivatives; Capsaicin; Dose-Response Relationship, Drug; Formaldehyde; Isoindoles; Male; Mice; Muscle Contraction; Nociceptors; Organoselenium Compounds; Pain; Pain Measurement; Rats; Rats, Wistar | 2003 |
Electroacupuncture induces the expression of Fos in rat dorsal horn via capsaicin-insensitive afferents.
Topics: Afferent Pathways; Animals; Animals, Newborn; Capsaicin; Electroacupuncture; Formaldehyde; Ganglia, Spinal; Gene Expression Regulation; Hindlimb; Immunohistochemistry; Male; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Drug; TRPV Cation Channels | 2003 |
A role for peripheral somatostatin receptors in counter-irritation-induced analgesia.
Topics: Analgesia; Animals; Behavior, Animal; Capsaicin; Cell Count; Drug Administration Routes; Drug Interactions; Formaldehyde; Freund's Adjuvant; Male; Microscopy, Electron; Pain; Pain Measurement; Peptides; Peptides, Cyclic; Peripheral Nerves; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Somatostatin; Time Factors | 2003 |
Antinociceptive profiles of crude extract from roots of Angelica gigas NAKAI in various pain models.
Topics: Administration, Oral; Analgesics; Angelica; Animals; Capsaicin; Cytokines; Excitatory Amino Acids; Formaldehyde; Hot Temperature; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Pain; Pain Measurement; Plant Extracts; Plant Roots; Postural Balance; Reaction Time; Substance P | 2003 |
Antinociceptive profile of (-)-spectaline: a piperidine alkaloid from Cassia leptophylla.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Capsaicin; Cassia; Dipyrone; Dose-Response Relationship, Drug; Flowers; Formaldehyde; Fruit; Hot Temperature; Indomethacin; Male; Mice; Pain; Phytotherapy; Piperidines; Plant Extracts | 2003 |
Evaluation of the anti-inflammatory, anti-nociceptive and gastric effects of Ginkgo biloba in the rat.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Edema; Foot; Formaldehyde; Gastric Acid; Ginkgo biloba; Injections, Subcutaneous; Melatonin; Pain Measurement; Plant Extracts; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Time Factors | 2004 |
Cholinergic modulation of nociceptive responses in vivo and neuropeptide release in vitro at the level of the primary sensory neuron.
Topics: Acetylcholine; Analysis of Variance; Animals; Arecoline; Atropine; Behavior, Animal; Bungarotoxins; Calcitonin Gene-Related Peptide; Capsaicin; Cell Count; Disinfectants; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Formaldehyde; Gallamine Triethiodide; Gene Expression Regulation; Grooming; In Situ Hybridization; In Vitro Techniques; Male; Mecamylamine; Mouth Mucosa; Muscarinic Antagonists; Neurons, Afferent; Nicotinic Antagonists; Pain; Pain Measurement; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptors, Drug; RNA, Messenger; Time; Trigeminal Ganglion | 2004 |
Altered behavioral responses to noxious stimuli and fear in glutamate receptor 5 (GluR5)- or GluR6-deficient mice.
Topics: Amygdala; Animals; Auditory Cortex; Behavior, Animal; Capsaicin; Conditioning, Classical; Excitatory Postsynaptic Potentials; Fear; Formaldehyde; GluK2 Kainate Receptor; Hot Temperature; Inflammation; Male; Memory; Mice; Mice, Knockout; Neuronal Plasticity; Pain; Reaction Time; Receptors, Kainic Acid | 2005 |
A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats.
Topics: Acute Disease; Analgesics; Animals; Capsaicin; Carrageenan; Chronic Disease; Dose-Response Relationship, Drug; Edema; Formaldehyde; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Inflammation; Isoquinolines; Ligation; Male; Motor Activity; Osteoarthritis; Pain; Pain Measurement; Pain, Postoperative; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, Drug; Sciatic Nerve; Spinal Nerves; Urea | 2005 |
Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa.
Topics: Acetic Acid; Analgesics; Animals; Arginine; Atropine; Behavior, Animal; Capsaicin; Cat's Claw; Dose-Response Relationship, Drug; Formaldehyde; Ketanserin; Male; Mice; Motor Activity; Naltrexone; Pain; Pain Measurement; Phytotherapy; Plant Preparations; Prazosin; Receptors, Serotonin, 5-HT2; Reserpine; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Yohimbine | 2005 |
Intrathecally-administered histamine facilitates nociception through tachykinin NK1 and histamine H1 receptors: a study in histidine decarboxylase gene knockout mice.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Behavior, Animal; Capsaicin; Excitatory Amino Acid Antagonists; Female; Formaldehyde; Histamine; Histidine Decarboxylase; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Neurokinin-1 Receptor Antagonists; Pain; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Receptors, Histamine H1; Receptors, Neurokinin-1; Substance P; Time Factors | 2005 |
Antinociceptive properties of the ethanolic extract and of the triterpene 3beta,6beta,16beta-trihidroxilup-20(29)-ene obtained from the flowers of Combretum leprosum in mice.
Topics: Acetic Acid; Analgesics; Animals; Arginine; Capsaicin; Combretum; Endorphins; Flowers; Formaldehyde; Glutamic Acid; Male; Mice; Motor Activity; Nitric Oxide; Pain; Pain Measurement; Plant Extracts; Psychomotor Performance; Reaction Time; Serotonin; Triterpenes | 2006 |
CB2 receptor-mediated antihyperalgesia: possible direct involvement of neural mechanisms.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; DNA Primers; DNA, Complementary; Formaldehyde; Hyperalgesia; Ligation; Male; Mice; Microglia; Nervous System Physiological Phenomena; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; RNA; Sciatic Nerve; Spinal Cord; Spinal Nerves; Transcription, Genetic | 2006 |
Antinociceptive and behavioral effects of ribavirin in mice.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Capsaicin; Formaldehyde; Male; Mice; Ribavirin | 2006 |
Analgesic activity of a non-peptide imidazolidinedione somatostatin agonist: in vitro and in vivo studies in rat.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Action Potentials; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Binding, Competitive; Bradykinin; Capsaicin; Colforsin; Drug Interactions; Formaldehyde; Hot Temperature; Imidazolidines; In Vitro Techniques; Inflammation; Male; Nerve Fibers; Pain; Rats; Rats, Sprague-Dawley; Reaction Time; Skin; Somatostatin; Thionucleotides | 2006 |
Formalin produces depolarizations in human airway smooth muscle in vitro.
Topics: Atropine; Bronchial Hyperreactivity; Bronchoconstriction; Capsaicin; Electrophysiology; Formaldehyde; Humans; In Vitro Techniques; Irritants; Membrane Potentials; Muscle, Smooth; Neuromuscular Depolarizing Agents; Substance P; Trachea | 2006 |
Synergistic antinociceptive effects of anandamide, an endocannabinoid, and nonsteroidal anti-inflammatory drugs in peripheral tissue: a role for endogenous fatty-acid ethanolamides?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Capsaicin; Chromatography, High Pressure Liquid; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Edema; Endocannabinoids; Formaldehyde; Ibuprofen; Lactones; Male; Mass Spectrometry; Nitrobenzenes; Pain Measurement; Peripheral Nervous System; Polyunsaturated Alkamides; Rats; Rats, Wistar; Sulfonamides; Sulfones; TRPV Cation Channels | 2006 |
The orofacial formalin test in the mouse: a behavioral model for studying physiology and modulation of trigeminal nociception.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Facial Pain; Formaldehyde; Lip; Male; Mice; Morphine; Narcotics; Nociceptors; Pain Measurement; Psychomotor Performance; Trigeminal Nerve | 2006 |
Roles of capsaicin-sensitive primary afferents in differential rat models of inflammatory pain: a systematic comparative study in conscious rats.
Topics: Analgesics, Non-Narcotic; Animals; Bee Venoms; Behavior, Animal; Capsaicin; Carrageenan; Edema; Formaldehyde; Hot Temperature; Hyperalgesia; Injections, Subcutaneous; Irritants; Male; Neuralgia; Neuritis; Neurons, Afferent; Nociceptors; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time | 2007 |
Static magnetic field-induced anti-nociceptive effect and the involvement of capsaicin-sensitive sensory nerves in this mechanism.
Topics: Analgesia; Animals; Capsaicin; Carrageenan; Chemoreceptor Cells; Diterpenes; Electromagnetic Fields; Formaldehyde; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred BALB C; Nerve Fibers; Neurons, Afferent; Pain Measurement; Postural Balance | 2007 |
Reduced pain behaviors and extracellular signal-related protein kinase activation in primary sensory neurons by peripheral tissue injury in mice lacking platelet-activating factor receptor.
Topics: Animals; Behavior, Animal; Capsaicin; Cell Count; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Extracellular Signal-Regulated MAP Kinases; Formaldehyde; Ganglia, Spinal; Male; Membrane Potentials; Mice; Mice, Knockout; Neurons, Afferent; Pain; Pain Measurement; Patch-Clamp Techniques; Peripheral Nervous System Diseases; Physical Stimulation; Platelet Membrane Glycoproteins; Reaction Time; Receptors, G-Protein-Coupled | 2007 |
Antinociceptive activity of petroleum ether fraction from the MeOH extracts of Paederia scandens in mice.
Topics: Acetic Acid; Alkanes; Analgesics; Animals; Capsaicin; Formaldehyde; Hot Temperature; Methanol; Mice; Mice, Inbred ICR; Motor Activity; Pain; Pentobarbital; Phytotherapy; Plant Extracts; Rubiaceae; Sleep | 2008 |
Involvement of peripheral TRPV1 in TMJ hyperalgesia induced by ethanol withdrawal.
Topics: Animals; Capsaicin; Central Nervous System Depressants; Ethanol; Formaldehyde; Male; Pain Measurement; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Temporomandibular Joint Dysfunction Syndrome; TRPV Cation Channels | 2007 |
Evidence for the involvement of glutamatergic and GABAergic systems and protein kinase A pathway in the antinociceptive effect caused by p-methoxy-diphenyl diselenide in mice.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetic Acid; Analgesics; Animals; Benzene Derivatives; Capsaicin; Cyclic AMP-Dependent Protein Kinases; Edema; Enzyme Activators; Excitatory Amino Acids; Female; Formaldehyde; gamma-Aminobutyric Acid; Glutamic Acid; Hot Temperature; Immersion; Injections, Spinal; Mice; Motor Activity; Organoselenium Compounds; Pain; Reaction Time; Signal Transduction | 2008 |
Antinoceptive effect of triterpenoid alpha,beta-amyrin in rats on orofacial pain induced by formalin and capsaicin.
Topics: Analgesics; Animals; Burseraceae; Capsaicin; Dose-Response Relationship, Drug; Drug Administration Schedule; Facial Pain; Formaldehyde; Male; Molecular Structure; Oleanolic Acid; Phytotherapy; Rats; Rats, Wistar | 2008 |
Reversal of pathological pain through specific spinal GABAA receptor subtypes.
Topics: Analgesics; Animals; Brain; Capsaicin; Chronic Disease; Diazepam; Disease Models, Animal; Fluorobenzenes; Formaldehyde; Ganglia, Spinal; Hot Temperature; Inflammation; Male; Mice; Neurons; Organ Specificity; Pain; Protein Isoforms; Protein Subunits; Rats; Rats, Wistar; Receptors, GABA-A; Spinal Cord; Triazoles | 2008 |
Antinociceptive activity of n-butanol fraction from MeOH extracts of Paederia scandens in mice.
Topics: 1-Butanol; Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Capsaicin; Constriction, Pathologic; Formaldehyde; Hot Temperature; Hypnotics and Sedatives; Methanol; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Pain Measurement; Pentobarbital; Plant Extracts; Reaction Time; Rubiaceae; Sleep; Solvents | 2007 |
Further antinociceptive properties of extracts and phenolic compounds from Plinia glomerata (Myrtaceae) leaves.
Topics: Acetic Acid; Acetone; Analgesics; Analgesics, Opioid; Animals; Capsaicin; Ellagic Acid; Formaldehyde; Glutamic Acid; Hot Temperature; Injections, Intraperitoneal; Male; Methanol; Mice; Morphine; Myrtaceae; Pain Measurement; Phenols; Plant Extracts; Plant Leaves; Solvents | 2008 |
Quercetin: further investigation of its antinociceptive properties and mechanisms of action.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Capsaicin; Cholinergic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Formaldehyde; GABA Agents; Glutamic Acid; Hot Temperature; Male; Mice; Motor Activity; Nitric Oxide Synthase; Pain; Pain Measurement; Pain Threshold; Quercetin; Reaction Time; Serotonin Antagonists; Signal Transduction | 2008 |
A BOLD-fMRI study of cerebral activation induced by injection of algesic chemical substances into the anesthetized rat forepaw.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Forelimb; Formaldehyde; Isoflurane; Magnetic Resonance Imaging; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Somatosensory Cortex; Specific Pathogen-Free Organisms; Stimulation, Chemical | 2008 |
Differential effects of topically applied formalin and aromatic compounds on neurogenic-mediated microvascular leakage in rat skin.
Topics: Administration, Topical; Animals; Antipruritics; Capillary Leak Syndrome; Capsaicin; Cell Degranulation; Disinfectants; Dose-Response Relationship, Drug; Formaldehyde; Hydrocarbons, Aromatic; Ketotifen; Male; Mast Cells; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Wistar; Regional Blood Flow; Skin | 2009 |
Acid increases inflammatory pain in rats: effect of local peripheral ASICs inhibitors.
Topics: Acid Sensing Ion Channels; Amiloride; Analgesics; Animals; Capsaicin; Female; Formaldehyde; Hydrogen-Ion Concentration; Inflammation; Nerve Tissue Proteins; Pain; Rats; Rats, Wistar; Serotonin; Sodium Channels | 2009 |
Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptors.
Topics: Action Potentials; Animals; Capsaicin; Female; Formaldehyde; Male; Membrane Transport Modulators; Mice; Mice, Knockout; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Nociceptors; Rats; Rats, Sprague-Dawley; Transient Receptor Potential Channels; TRPA1 Cation Channel | 2009 |
Antinociceptive activity of Paederosidic Acid Methyl Ester (PAME) from the n-butanol fraction of Paederia scandens in mice.
Topics: 1-Butanol; Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Body Temperature; Capsaicin; Formaldehyde; Glucosides; Hot Temperature; Hypnotics and Sedatives; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Pain Measurement; Pentobarbital; Plant Extracts; Reaction Time; Rubiaceae; Sleep; Solvents | 2009 |
Antinociceptive and anti-allodynic effects of 3-alkynyl selenophene on different models of nociception in mice.
Topics: Analgesics; Animals; Bradykinin; Capsaicin; Formaldehyde; Freund's Adjuvant; Glutamic Acid; Hot Temperature; Hyperalgesia; Immersion; Inflammation; Male; Mice; Motor Activity; Organoselenium Compounds; Pain Measurement; Reaction Time; Tetradecanoylphorbol Acetate | 2009 |
Antinociceptive activity of a new benzofuranone derived from a chalcone.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Benzofurans; Capsaicin; Chalcone; Dose-Response Relationship, Drug; Formaldehyde; Glutamic Acid; Linear Models; Male; Mice; Nociception; Pain; Pain Measurement | 2009 |
Mediating roles of the vanilloid receptor TRPV1 in activation of rat primary afferent nociceptive neurons by formaldehyde.
Topics: Acetanilides; Action Potentials; Animals; Capsaicin; Formaldehyde; Ganglia, Spinal; Nociceptors; Pain; Pain Measurement; Patch-Clamp Techniques; Purines; Rats; Rats, Sprague-Dawley; TRPV Cation Channels | 2009 |
Development of mechanisms associated with neurogenic-mediated skin inflammation during the growth of rats.
Topics: Age Factors; Animals; Capsaicin; Cell Degranulation; Female; Fixatives; Formaldehyde; Male; Mast Cells; Nerve Fibers, Unmyelinated; Neurogenic Inflammation; Neurotransmitter Agents; Rats; Rats, Wistar; Receptors, Neurokinin-1; Sensory System Agents; Skin; Substance P | 2010 |
The antinociceptive and anti-inflammatory activities of caulerpin, a bisindole alkaloid isolated from seaweeds of the genus Caulerpa.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Carrageenan; Caulerpa; Dose-Response Relationship, Drug; Edema; Female; Formaldehyde; Indole Alkaloids; Indoles; Male; Mice; Pain; Peritonitis; Seaweed | 2009 |
Antinociceptive effect of Zanthoxylum rhoifolium Lam. (Rutaceae) in models of acute pain in rodents.
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Dizocilpine Maleate; Ethanol; Female; Formaldehyde; Glutamic Acid; Locomotion; Male; Mice; Morphine; Pain; Pentacyclic Triterpenes; Phytotherapy; Plant Bark; Plant Extracts; Plant Stems; Zanthoxylum | 2010 |
Differential ATF3 expression in dorsal root ganglion neurons reveals the profile of primary afferents engaged by diverse noxious chemical stimuli.
Topics: Activating Transcription Factor 3; Analysis of Variance; Animals; Capsaicin; Cell Count; Formaldehyde; Ganglia, Spinal; Immunohistochemistry; Menthol; Mice; Mice, Knockout; Mustard Plant; Neurons, Afferent; Nociceptors; Pain Measurement; Plant Oils; TRPV Cation Channels | 2010 |
Antinociceptive effects of citronellal in formalin-, capsaicin-, and glutamate-induced orofacial nociception in rodents and its action on nerve excitability.
Topics: Action Potentials; Acyclic Monoterpenes; Aldehydes; Analgesics; Animals; Capsaicin; Facial Pain; Formaldehyde; Glutamates; Male; Mice; Monoterpenes; Morphine; Motor Activity; Narcotics; Neural Conduction; Nociceptors; Pain; Rats; Rats, Wistar; Sciatic Nerve; Sensory System Agents | 2010 |
Differential distribution of activated spinal neurons containing glycine and/or GABA and expressing c-fos in acute and chronic pain models.
Topics: Animals; Capsaicin; Cell Count; Disease Models, Animal; Formaldehyde; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamate Decarboxylase; Glycine; Glycine Plasma Membrane Transport Proteins; Male; Pain; Pain Threshold; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; RNA, Messenger; Sensory Receptor Cells; Spinal Cord | 2010 |
Bioassay-guided evaluation of antioxidant and antinociceptive activities of carvacrol.
Topics: Analgesics; Animals; Antioxidants; Capsaicin; Cymenes; Drug Evaluation; Formaldehyde; Male; Mice; Monoterpenes; Pain; Pain Measurement; Plant Extracts; Reaction Time | 2010 |
TRPA1 receptors mediate environmental irritant-induced meningeal vasodilatation.
Topics: Acetanilides; Acrolein; Animals; Animals, Newborn; Ankyrins; Calcitonin Gene-Related Peptide; Calcium Channels; Capsaicin; Cells, Cultured; Dose-Response Relationship, Drug; Formaldehyde; Garlic; Laser-Doppler Flowmetry; Meningeal Arteries; Mustard Plant; Neurons; Peptide Fragments; Plant Oils; Purines; Rats; Sensory System Agents; Substance P; Trigeminal Ganglion; TRPA1 Cation Channel; TRPC Cation Channels; Vasodilation | 2011 |
VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity.
Topics: Animals; Behavior, Animal; Capsaicin; Cold Temperature; Fixatives; Formaldehyde; Ganglia, Spinal; Gene Expression Regulation; Hot Temperature; Hyperalgesia; Mice; Mice, Knockout; Nociceptors; Pain; Sensory System Agents; Vesicular Glutamate Transport Protein 2 | 2010 |
Spinal transient receptor potential ankyrin 1 channel contributes to central pain hypersensitivity in various pathophysiological conditions in the rat.
Topics: Acetanilides; Analysis of Variance; Animals; Ankyrins; Calcium Channels; Capsaicin; Cholecystokinin; Cinnamomum zeylanicum; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Hyperalgesia; Male; N-Methylaspartate; Pain Measurement; Peripheral Nervous System Diseases; Purines; Rats; Rats, Wistar; Sleep Deprivation; Spinal Cord; TRPA1 Cation Channel; TRPC Cation Channels | 2011 |
Group II/III metabotropic glutamate receptors exert endogenous activity-dependent modulation of TRPV1 receptors on peripheral nociceptors.
Topics: Amino Acids; Animals; Calcium; Capsaicin; Cells, Cultured; Cytosol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Formaldehyde; Glutamic Acid; Hot Temperature; Male; Nociceptors; Pain; Pain Measurement; Peripheral Nervous System; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Skin; TRPV Cation Channels; Xanthenes | 2011 |
Activation of spinal mu- and delta-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli.
Topics: Animals; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Formaldehyde; Injections, Spinal; Male; Mice; Mice, Knockout; Neurons; Neurons, Afferent; Oligopeptides; Pain; Pain Measurement; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Substance P; Tachykinins | 2011 |
Suppressive effects of glycyrrhetinic acid derivatives on tachykinin receptor activation and hyperalgesia.
Topics: Analgesics; Animals; Calcium; Capsaicin; CHO Cells; Cricetinae; Disease Models, Animal; Formaldehyde; Glycyrrhetinic Acid; Hot Temperature; Humans; Hyperalgesia; Inflammation; Ligation; Male; Neuralgia; Neurokinin A; Neurokinin B; Pain; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Sciatic Nerve; Substance P | 2011 |
Antihyperalgesic effects of clomipramine and tramadol in a model of posttraumatic trigeminal neuropathic pain in mice.
Topics: Acetone; Analgesics, Opioid; Animals; Capsaicin; Clomipramine; Disease Models, Animal; Formaldehyde; Hyperalgesia; Irritants; Male; Mice; Nociceptors; Orbit; Pruritus; Selective Serotonin Reuptake Inhibitors; Sensory System Agents; Tramadol; Transient Receptor Potential Channels; Trigeminal Nerve Injuries; Trigeminal Neuralgia; TRPA1 Cation Channel; TRPV Cation Channels; Vibrissae | 2011 |
Transient receptor potential vanilloid 1 - a polymodal nociceptive receptor - plays a crucial role in formaldehyde-induced skin inflammation in mice.
Topics: Animals; Capsaicin; Disease Models, Animal; Drug Eruptions; Female; Formaldehyde; Inflammation; Mice; Mice, Inbred BALB C; Mice, Knockout; Nerve Growth Factors; RNA, Messenger; Time Factors; TRPV Cation Channels | 2012 |
The combined predictive capacity of rat models of algogen-induced and neuropathic hypersensitivity to clinically used analgesics varies with nociceptive endpoint and consideration of locomotor function.
Topics: Amines; Analgesics; Animals; Capsaicin; Cyclohexanecarboxylic Acids; Disease Models, Animal; Duloxetine Hydrochloride; Exploratory Behavior; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Locomotion; Male; Morphine; Neuralgia; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiophenes | 2012 |
Evaluation of antinociceptive effects of Crassocephalum bauchiense Hutch (Asteraceae) leaf extract in rodents.
Topics: Acetic Acid; Administration, Oral; Alkaloids; Analgesics; Analgesics, Opioid; Animals; Asteraceae; Behavior, Animal; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Formaldehyde; Glutamic Acid; Hot Temperature; Male; Mice; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Pain; Pain Threshold; Phytotherapy; Plant Extracts; Plant Leaves; Plants, Medicinal; Solvents; Time Factors; Water | 2012 |
Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization.
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Electric Stimulation; Formaldehyde; Gene Expression Regulation; Male; Mice; Morpholines; Neuralgia; Pain Measurement; Pyrazoles; Receptors, sigma; Sigma-1 Receptor | 2012 |
The involvement of the spinal release of glutamate and nitric oxide in peripheral noxious stimulation-induced pain-related behaviors--study in mouse spinal microdialysis.
Topics: Animals; Behavior, Animal; Capsaicin; Formaldehyde; Glutamic Acid; Male; Mice; Microdialysis; Nitric Oxide; Pain; Pain Measurement; Spinal Cord | 2012 |
Peripheral antinociceptive effect of anandamide and drugs that affect the endocannabinoid system on the formalin test in normal and streptozotocin-diabetic rats.
Topics: Analgesics; Animals; Arachidonic Acids; Behavior, Animal; Capsaicin; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Endocannabinoids; Formaldehyde; Hyperalgesia; Indoles; Male; Pain Measurement; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Cannabinoid | 2012 |
Role of C-fibers during acute and chronic stress on formalin-induced paw edema in rats.
Topics: Animals; Capsaicin; Dexamethasone; Edema; Formaldehyde; Inflammation; Male; Nerve Fibers, Unmyelinated; Rats; Rats, Wistar; Stress, Physiological; Swimming | 2012 |
Orofacial antinociceptive effect and antioxidant properties of the hydroethanol extract of Hyptis fruticosa salmz ex Benth.
Topics: Analgesics; Animals; Antioxidants; Behavior, Animal; Capsaicin; Ethanol; Facial Pain; Formaldehyde; Glutamic Acid; Hyptis; Male; Mice; Phenols; Phytotherapy; Plant Extracts; Plant Leaves; Solvents; Terpenes; Thiobarbituric Acid Reactive Substances | 2013 |
Antinociceptive effect of Lecythis pisonis Camb. (Lecythidaceae) in models of acute pain in mice.
Topics: Acetic Acid; Acute Pain; Analgesics; Animals; Arginine; Behavior, Animal; Capsaicin; Disease Models, Animal; Formaldehyde; Glutamic Acid; Glyburide; Lecythidaceae; Male; Mice; Naloxone; Narcotic Antagonists; Phytotherapy; Plant Extracts; Plant Leaves | 2013 |
Anti-hyperalgesic activity of corilagin, a tannin isolated from Phyllanthus niruri L. (Euphorbiaceae).
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Capsaicin; Formaldehyde; Glucosides; Glutamic Acid; Hot Temperature; Hydrolyzable Tannins; Hyperalgesia; Male; Mice; Motor Activity; Phyllanthus; Phytotherapy | 2013 |
Cellular mechanism underlying formaldehyde-stimulated Cl- secretion in rat airway epithelium.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Anions; Biological Transport; Capsaicin; Cells, Cultured; Chlorides; Colforsin; Epinephrine; Epithelial Cells; Formaldehyde; Imines; Male; Nerve Endings; ortho-Aminobenzoates; Quinuclidines; Rats; Respiratory Mucosa; Substance P; Trachea; TRPV Cation Channels | 2013 |
Impaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory pain.
Topics: Animals; Behavior, Animal; Biopterins; Biosynthetic Pathways; Capsaicin; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Disease Models, Animal; Dystonic Disorders; Formaldehyde; Freund's Adjuvant; GTP Cyclohydrolase; Hot Temperature; Inflammation; Inheritance Patterns; Mice; Mice, Inbred C57BL; Motor Activity; Nociception; Pain; Phenylketonurias; Physical Stimulation; Rats; Stress, Mechanical | 2013 |
Anti-nociceptive and anti-allodynic activity of aliskiren in various pain models.
Topics: Acetic Acid; Amides; Analgesics; Animals; Behavior, Animal; Capsaicin; Female; Formaldehyde; Fumarates; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Motor Activity; Pain; Rats; Rats, Sprague-Dawley | 2013 |
Role of transient receptor potential ion channels and evoked levels of neuropeptides in a formaldehyde-induced model of asthma in BALB/c mice.
Topics: Acetanilides; Animals; Asthma; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Formaldehyde; Immunoglobulin E; Immunohistochemistry; Interleukin-1beta; Interleukin-4; Interleukin-6; Lung; Male; Mice; Mice, Inbred BALB C; Neuropeptides; Ovalbumin; Purines; Substance P; Transient Receptor Potential Channels | 2013 |
Ursolic acid from Agastache mexicana aerial parts produces antinociceptive activity involving TRPV1 receptors, cGMP and a serotonergic synergism.
Topics: Analgesics; Animals; Capsaicin; Chromatography, High Pressure Liquid; Cyclic GMP; Female; Formaldehyde; Male; Mice; Plant Components, Aerial; Plant Extracts; Rats; Rats, Wistar; Serotonin; Triterpenes; TRPV Cation Channels; Ursolic Acid | 2013 |
Mechanisms underlying the antinociceptive effect of mangiferin in the formalin test.
Topics: Analgesics; Animals; Capsaicin; Formaldehyde; Glyburide; Male; Naloxone; Naltrexone; NG-Nitroarginine Methyl Ester; Nociception; Quinoxalines; Rats; Rats, Wistar; Serotonin; Xanthones | 2013 |
Antinociceptive effects of ethanolic extract from the flowers of Acmella oleracea (L.) R.K. Jansen in mice.
Topics: Acrolein; Analgesics; Animals; Asteraceae; Capsaicin; Ethanol; Flowers; Formaldehyde; Hot Temperature; Hyperalgesia; Ligation; Male; Mice; Pain; Phytotherapy; Plant Extracts; Sciatic Nerve; Solvents; Touch | 2013 |
β-cyclodextrin complex containing Lippia grata leaf essential oil reduces orofacial nociception in mice - evidence of possible involvement of descending inhibitory pain modulation pathway.
Topics: Animals; beta-Cyclodextrins; Capsaicin; Facial Pain; Formaldehyde; Glutamic Acid; Lippia; Male; Mice; Morphine; Nociception; Oils, Volatile; Pain Measurement; Periaqueductal Gray; Plant Leaves | 2014 |
Spinal distribution of c-Fos activated neurons expressing enkephalin in acute and chronic pain models.
Topics: Analysis of Variance; Animals; Capsaicin; Disease Models, Animal; Enkephalins; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Male; Neurons; Pain; Pain Threshold; Polymers; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; RNA, Messenger; Spinal Cord; Time Factors | 2014 |
Anti-inflammatory and antinociceptive effects of Sterculia striata A. St.-Hil. & Naudin (Malvaceae) in rodents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Carrageenan; Dextrans; Edema; Formaldehyde; Glutamic Acid; Histamine; Inflammation; Male; Mice; Naloxone; Pain; Phytotherapy; Plant Bark; Plant Extracts; Plant Stems; Rats, Wistar; Sterculia | 2014 |
Antinociceptive and anti-inflammatory effects of flavonoids PMT1 and PMT2 isolated from Piper montealegreanum Yuncker (Piperaceae) in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Disease Models, Animal; Edema; Flavonoids; Formaldehyde; Male; Mice; Molecular Structure; Pain; Pain Measurement; Piper | 2014 |
Antinociceptive esters of N-methylanthranilic acid: Mechanism of action in heat-mediated pain.
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Formaldehyde; Glutamic Acid; Hot Temperature; KATP Channels; Male; Mice; Motor Activity; Narcotic Antagonists; Neurotransmitter Agents; ortho-Aminobenzoates; Pain; Pain Perception; Pain Threshold; Potassium Channel Blockers; Reaction Time; Time Factors | 2014 |
Intraganglionar resiniferatoxin prevents orofacial inflammatory and neuropathic hyperalgesia.
Topics: Animals; Capsaicin; Carrageenan; Cold Temperature; Disease Models, Animal; Diterpenes; Facial Pain; Formaldehyde; Hot Temperature; Hyperalgesia; Male; Neuralgia; Neurons; Nociception; Rats; Rats, Wistar; Sensory System Agents; Trigeminal Ganglion; TRPV Cation Channels | 2014 |
The induction of long-term potentiation in spinal dorsal horn after peripheral nociceptive stimulation and contribution of spinal TRPV1 in rats.
Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Central Nervous System Agents; Electric Stimulation; Formaldehyde; Freund's Adjuvant; Long-Term Potentiation; Male; Microelectrodes; Nociception; Posterior Horn Cells; Rats, Sprague-Dawley; Sciatic Nerve; TRPV Cation Channels | 2014 |
Citral: a monoterpene with prophylactic and therapeutic anti-nociceptive effects in experimental models of acute and chronic pain.
Topics: Acute Pain; Acyclic Monoterpenes; Analgesics; Animals; Capsaicin; Chronic Pain; Excitatory Amino Acids; Formaldehyde; Glutamic Acid; Hyperalgesia; Ischemia; Ketanserin; Male; Mice; Monoterpenes; Neuralgia; Pain, Postoperative; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Serotonin 5-HT2 Receptor Antagonists; Stomach Ulcer; Substance P; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2014 |
Role of TRPV1 and ASIC3 in formalin-induced secondary allodynia and hyperalgesia.
Topics: Acid Sensing Ion Channels; Amiloride; Animals; Blotting, Western; Capsaicin; Cnidarian Venoms; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Ganglia, Spinal; Hyperalgesia; Pyridines; Rats; Sulfones; Time Factors; TRPV Cation Channels | 2014 |
Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice.
Topics: Acetanilides; Analgesics; Animals; Benzamides; Capsaicin; Cold Temperature; Disease Models, Animal; Formaldehyde; Hyperalgesia; Isothiocyanates; Male; Mice; Neuralgia; Oximes; Paclitaxel; Pain Measurement; Purines; Thiophenes; Touch; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPM Cation Channels; TRPV Cation Channels | 2015 |
Endovanilloid control of pain modulation by the rostroventromedial medulla in an animal model of diabetic neuropathy.
Topics: Amides; Amidohydrolases; Analgesics, Non-Narcotic; Animals; Arachidonic Acids; Capsaicin; Chronic Pain; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Endocannabinoids; Ethanolamines; Formaldehyde; Male; Medulla Oblongata; Nociceptive Pain; Oleic Acids; Palmitic Acids; Polyunsaturated Alkamides; Rats, Wistar; RNA, Messenger; TRPV Cation Channels | 2016 |
Antinociceptive effects of the aqueous and methanol extracts of the leaves of Pittosporum mannii Hook. F. (Pittosporaceae) in mice.
Topics: Acetic Acid; Analgesics; Animals; Artemia; Capsaicin; Female; Formaldehyde; Glutamic Acid; Hot Temperature; Larva; Lethal Dose 50; Male; Methanol; Mice; Motor Activity; Pain; Phytochemicals; Phytotherapy; Plant Extracts; Plant Leaves; Rosales; Rotarod Performance Test; Solvents; Water | 2016 |
A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase.
Topics: Acrylamides; Amidohydrolases; Analgesia; Animals; Arachidonic Acid; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Carrageenan; Disease Models, Animal; Ethanolamines; Formaldehyde; Genotype; Hyperalgesia; Inflammation; Injections, Intraperitoneal; Ligands; Lumbar Vertebrae; Mice, Inbred C57BL; Mice, Knockout; Nociception; Pain; Pain Threshold; Phenotype; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Receptor, Cannabinoid, CB1; Skin; Spinal Cord Dorsal Horn; TRPV Cation Channels | 2016 |
The leguminous lectin of Lonchocarpus araripensis promotes antinociception via mechanisms that include neuronal inhibition of Na(+) currents.
Topics: Analgesics; Animals; Capsaicin; Fabaceae; Formaldehyde; Ganglia, Spinal; Hot Temperature; Lectins; Male; Mice; Neurons; Nociception; Pain; Physical Stimulation; Rats, Wistar; Seeds; Sodium Channels | 2016 |
Evidence for the involvement of TNF-α and IL-1β in the antinociceptive and anti-inflammatory activity of Stachys lavandulifolia Vahl. (Lamiaceae) essential oil and (-)-α-bisabolol, its main compound, in mice.
Topics: Analgesics; Animals; Anti-Infective Agents; Capsaicin; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Facial Pain; Flame Ionization; Formaldehyde; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Interleukin-1beta; Male; Mice; Monocyclic Sesquiterpenes; Nociception; Nociceptive Pain; Oils, Volatile; Phytotherapy; Plant Extracts; Plant Oils; Plants, Medicinal; Pleurisy; Sesquiterpenes; Stachys; Time Factors; Tumor Necrosis Factor-alpha | 2016 |
Tabernaemontana catharinensis ethyl acetate fraction presents antinociceptive activity without causing toxicological effects in mice.
Topics: Acetates; Acetic Acid; Administration, Oral; Analgesics; Animals; Apocynaceae; Behavior, Animal; Capsaicin; Cell Survival; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Motor Activity; Nociception; Nociceptive Pain; Pain Threshold; Phytotherapy; Plant Extracts; Plant Leaves; Plants, Medicinal; Risk Assessment; Rotarod Performance Test; Solvents; Time Factors; Toxicity Tests | 2016 |
The mitogen and stress-activated protein kinase 1 regulates the rapid epigenetic tagging of dorsal horn neurons and nocifensive behaviour.
Topics: 5,6-Dihydroxytryptamine; Acute Pain; Adrenergic Uptake Inhibitors; Animals; Capsaicin; Desipramine; Disease Models, Animal; Formaldehyde; Histones; Male; Mitogen-Activated Protein Kinase 8; Mitogens; Pain Measurement; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Sensory System Agents; Serotonin; Signal Transduction; Up-Regulation | 2016 |
The role of trigeminal nucleus caudalis orexin 1 receptor in orofacial pain-induced anxiety in rat.
Topics: Animals; Anxiety; Benzoxazoles; Capsaicin; Disease Models, Animal; Exploratory Behavior; Facial Pain; Formaldehyde; Male; Maze Learning; Microinjections; Naphthyridines; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Pain Measurement; Rats; Rats, Wistar; Time Factors; Trigeminal Nuclei; Urea | 2016 |
Mild Social Stress in Mice Produces Opioid-Mediated Analgesia in Visceral but Not Somatic Pain States.
Topics: Acetic Acid; Animals; Capsaicin; Corticosterone; Cues; Disease Models, Animal; Formaldehyde; Male; Mice; Naloxone; Narcotic Antagonists; Nociception; Pain; Receptors, Opioid; Recognition, Psychology; Social Behavior; Stress, Psychological; Visual Perception | 2017 |
The spider toxin Phα1β recombinant possesses strong analgesic activity.
Topics: Analgesics, Non-Narcotic; Animals; Calcium Channel Blockers; Capsaicin; Formaldehyde; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neuralgia; Nociceptive Pain; Rats, Wistar; Recombinant Proteins; Sciatic Nerve; Spider Venoms | 2017 |
Comparison of the induction of c-fos-eGFP and Fos protein in the rat spinal cord and hypothalamus resulting from subcutaneous capsaicin or formalin injection.
Topics: Animals; Arginine Vasopressin; Capsaicin; Formaldehyde; Genes, fos; Green Fluorescent Proteins; Hypothalamus; Neurons; Paraventricular Hypothalamic Nucleus; Proto-Oncogene Proteins c-fos; Rats, Transgenic; Spinal Cord; Supraoptic Nucleus | 2017 |
Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment.
Topics: Animals; Capsaicin; Dermatitis, Atopic; Disease Models, Animal; Formaldehyde; Humans; Infant, Newborn; Rats | 2017 |
Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission.
Topics: Adrenergic Antagonists; Animals; Calcitonin Gene-Related Peptide; Calcitonin Receptor-Like Protein; Capsaicin; Cholestanols; Clathrin; Dynamins; Endocytosis; Endosomes; Formaldehyde; Freund's Adjuvant; Gene Expression Regulation; Injections, Spinal; Male; Mice; Microtomy; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nociception; Pain; Peptide Fragments; Protein Kinase C; Rats; Spinal Cord; Synaptic Transmission; Tissue Culture Techniques | 2017 |
New
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Coffee; Disease Models, Animal; Female; Formaldehyde; Glutamic Acid; Hot Temperature; Hyperalgesia; Male; Mice; Naloxone; Narcotic Antagonists; Ondansetron; Pain; Pain Measurement; Piperidines; Pyrazoles; Serotonin | 2018 |
Effects of isopulegol in acute nociception in mice: Possible involvement of muscarinic receptors, opioid system and l-arginine/NO/cGMP pathway.
Topics: Acute Disease; Administration, Oral; Analgesics; Animals; Arginine; Behavior, Animal; Capsaicin; Cyclic GMP; Cyclohexane Monoterpenes; Female; Formaldehyde; Glutamic Acid; Male; Mice; Nitric Oxide; Pain; Receptors, Muscarinic; Receptors, Opioid; Signal Transduction; Terpenes | 2018 |
Oleanolic acid promotes orofacial antinociception in adult zebrafish (Danio rerio) through TRPV1 receptors.
Topics: Acetanilides; Analgesics; Animals; Behavior, Animal; Binding Sites; Capsaicin; Facial Pain; Formaldehyde; Molecular Docking Simulation; Oleanolic Acid; Protein Structure, Tertiary; Purines; Ruthenium Red; Thermodynamics; TRPV Cation Channels; Zebrafish; Zebrafish Proteins | 2019 |
Analgesic Activity of Novel GABA Esters after Transdermal Delivery.
Topics: Acute Pain; Administration, Cutaneous; Analgesics, Non-Narcotic; Animals; Capsaicin; Esters; Formaldehyde; gamma-Aminobutyric Acid; Hot Temperature; Male; Mice; Pain Measurement; Terpenes | 2016 |
Possible involvement of peripheral TRP channels in the hydrogen sulfide-induced hyperalgesia in diabetic rats.
Topics: Acetanilides; Analgesics; Animals; Capsaicin; Cystathionine beta-Synthase; Diabetes Mellitus, Experimental; Female; Formaldehyde; Hydrogen Sulfide; Hydroxylamine; Hyperalgesia; Imidazoles; Nociception; Purines; Rats, Wistar; Skin; Spinal Nerve Roots; Sulfites; Transient Receptor Potential Channels | 2019 |
Comparison of antinociceptive effects of plain lidocaine versus lidocaine complexed with hydroxypropyl-β-cyclodextrin in animal models of acute and persistent orofacial pain.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Analgesics; Animals; Capsaicin; Carrageenan; Disease Models, Animal; Formaldehyde; Hot Temperature; Hyperalgesia; Lidocaine; Male; Pain; Rats, Wistar | 2019 |
Pharmacological studies on aqueous extract of Launaea arborescens from southwest Algeria.
Topics: Algeria; Analgesics; Animals; Anti-Inflammatory Agents; Asteraceae; Behavior, Animal; Capsaicin; Edema; Formaldehyde; Histamine; Hot Temperature; Inflammation; Male; Medicine, Traditional; Mice, Inbred BALB C; Pain; Pain Measurement; Plant Extracts; Serotonin; Solutions; TRPV Cation Channels | 2021 |
Antinociceptive and Anti-inflammatory Effect of Corynoline in Different Nociceptive and Inflammatory Experimental Models.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Berberine Alkaloids; Capsaicin; Carrageenan; Cytokines; Edema; Formaldehyde; Glutamates; Inflammation; Inflammation Mediators; Mice; Models, Theoretical; Nociception; Pain; Plant Extracts; Water | 2022 |
Emodin Reduces Inflammatory and Nociceptive Responses in Different Pain-and Inflammation-Induced Mouse Models.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Emodin; Formaldehyde; Glutamates; Inflammation; Mice; Pain; Plant Extracts | 2023 |
A monoclonal antibody for identifying capsaicin congeners in illegal cooking oil and its applications.
Topics: Antibodies, Monoclonal; Capsaicin; Carrier Proteins; Cooking; Formaldehyde; Haptens | 2022 |
Antinociceptive effects of nortriptyline and desipramine hydrochloride in Speke's hinge-back tortoise (Kinixys Spekii).
Topics: Analgesics; Animals; Capsaicin; Desipramine; Formaldehyde; Nortriptyline; Pain; Turtles | 2023 |
Repeated gentle handling or maternal deprivation during the neonatal stage increases adult male rats' baseline orofacial pain responsiveness.
Topics: Animals; Capsaicin; Facial Pain; Formaldehyde; Male; Maternal Deprivation; Nitroglycerin; Nociception; Rats | 2023 |
Mechanisms involved in the antinociceptive and anti-inflammatory effects of xanthotoxin.
Topics: Acute Pain; Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Chronic Pain; Formaldehyde; Ganglia, Spinal; Hyperalgesia; Inflammation; Methoxsalen; Mice | 2023 |