fomepizole has been researched along with pyrazole in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (40.74) | 18.7374 |
| 1990's | 14 (51.85) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (7.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bohlken, DP; Fries, RW; Plapp, BV | 1 |
| Cornell, NW; Hansch, C; Klein, T; Langridge, R; McClarin, J | 1 |
| Cederbaum, AI; Winters, DK | 3 |
| Cederbaum, AI; Dicker, E; McHugh, T | 2 |
| Carr, EP; Keeling, PW; Tipton, KF | 1 |
| Cederbaum, AI; Clejan, L; Potter, B; Wu, DF | 1 |
| Cederbaum, AI; Clejan, LA | 1 |
| Boleda, MD; Julià, P; Moreno, A; Parés, X | 1 |
| Taberner, PV; Unwin, JW | 1 |
| Hoshino, T; Ishiguro, I; Ohta, Y | 1 |
| Daniel, DS; Irving, CC | 1 |
| Cederbaum, AI; Feierman, DE | 2 |
| Cederbaum, AI; Feierman, DE; Krikun, G | 1 |
| Berl, L; Cederbaum, AI | 1 |
| Amit, Z; Brown, ZW; Carr, G; Rockman, GE | 1 |
| Eisses, KT | 2 |
| Cederbaum, AI; Wu, D | 2 |
| Juvonen, R; Kojo, A; Pasanen, M; Pelkonen, O; Raunio, H; Viitala, P | 1 |
| Dawidek-Pietryka, K; Dudka, J; Mazur, M; Szczepaniak, S | 1 |
| Beike, J; Bender, K; Jübner, M; Käferstein, H; Lenz, D; Rothschild, MA; Wintermeyer, A | 1 |
| Clemens, DL; Dey, A; Swaminathan, K | 1 |
27 other study(ies) available for fomepizole and pyrazole
| Article | Year |
|---|---|
3-Substituted pyrazole derivatives as inhibitors and inactivators of liver alcohol dehydrogenase.
Topics: Alcohol Oxidoreductases; Animals; Horses; In Vitro Techniques; Liver; NAD; Pyrazoles; Spectrophotometry, Ultraviolet | 1979 |
A quantitative structure-activity relationship and molecular graphics analysis of hydrophobic effects in the interactions of inhibitors with alcohol dehydrogenase.
Topics: Acetamides; Alcohol Dehydrogenase; Alcohol Oxidoreductases; Animals; Benzylamines; Crystallography; Enzyme Inhibitors; Horses; Humans; Liver; Mathematics; Models, Molecular; Pyrazoles; Structure-Activity Relationship; X-Ray Diffraction | 1986 |
The content and activity of cytochrome P450 2E1 in liver microsomes from alcohol-preferring and non-preferring rats.
Topics: Alcoholism; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Fomepizole; Immunoblotting; Methylcholanthrene; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains | 1992 |
Time course characterization of the induction of cytochrome P-450 2E1 by pyrazole and 4-methylpyrazole.
Topics: Animals; Base Sequence; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Enzyme Induction; Fomepizole; Immunoblotting; Male; Molecular Sequence Data; Nitrophenols; Oligonucleotide Probes; Oxazines; Oxidoreductases, N-Demethylating; Pyrazoles; Rats; Rats, Inbred Strains; RNA, Messenger; Time Factors | 1992 |
Increased catalytic activity of cytochrome P-450IIE1 in pericentral hepatocytes compared to periportal hepatocytes isolated from pyrazole-treated rats.
Topics: Aniline Compounds; Animals; Carbon Monoxide; Catalysis; Cytochrome P-450 CYP2E1; Fomepizole; gamma-Glutamyltransferase; Glutamate-Ammonia Ligase; Liver; Male; Nitrophenols; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Pyrazoles; Rats; Rats, Inbred Strains; Tissue Distribution | 1991 |
The effects of histamine H2 receptor antagonists on the activity of horse liver alcohol dehydrogenase.
Topics: Alcohol Dehydrogenase; Animals; Binding, Competitive; Cimetidine; Fomepizole; Histamine H2 Antagonists; Horses; Imidazoles; Kinetics; Liver; Pyrazoles | 1991 |
Increased oxidation of p-nitrophenol and aniline by intact hepatocytes isolated from pyrazole-treated rats.
Topics: Aniline Compounds; Animals; Cells, Cultured; Fomepizole; Kinetics; Liver; Male; Microsomes, Liver; NADP; Nitrophenols; Oxidation-Reduction; Pyrazoles; Rats; Rats, Inbred Strains | 1990 |
Rapid decrease of cytochrome P-450IIE1 in primary hepatocyte culture and its maintenance by added 4-methylpyrazole.
Topics: Animals; Blotting, Northern; Blotting, Western; Cells, Cultured; Cytochrome P-450 CYP2E1; Enzyme Induction; Fomepizole; Liver; Male; Microscopy, Phase-Contrast; Microsomes, Liver; Oxidoreductases, N-Demethylating; Pyrazoles; Rats; Rats, Inbred Strains; RNA, Messenger | 1990 |
Oxidation of glycerol to formaldehyde by rat liver microsomes. Effects of cytochrome P-450 inducing agents.
Topics: Acetone; Aldehyde Oxidoreductases; Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Fomepizole; Formaldehyde; Glycerol; Isoenzymes; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NAD; Oxidation-Reduction; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains | 1990 |
Oxidation of pyrazole by reconstituted systems containing cytochrome P-450 IIE1.
Topics: Alcohol Dehydrogenase; Aniline Compounds; Antibodies; Binding, Competitive; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Fomepizole; Glycerol; Isoenzymes; Liver; Oxidation-Reduction; Pyrazoles; Substrate Specificity | 1990 |
Role of extrahepatic alcohol dehydrogenase in rat ethanol metabolism.
Topics: Alcohol Dehydrogenase; Animals; Ethanol; Female; Fomepizole; Isoenzymes; Kinetics; Liver; Male; Organ Specificity; Pyrazoles; Rats; Rats, Inbred Strains | 1989 |
Non-specific prolongation of the effects of general depressants by pyrazole and 4-methylpyrazole.
Topics: Animals; Central Nervous System Depressants; Drug Synergism; Fomepizole; Mice; Mice, Inbred Strains; Postural Balance; Pyrazoles | 1987 |
Rabbit liver alcohol dehydrogenase: purification and properties.
Topics: Alcohol Dehydrogenase; Alcohol Oxidoreductases; Amino Acids; Animals; Chromatography, Affinity; Fomepizole; Glutathione; Hydrogen-Ion Concentration; Kinetics; Liver; Pyrazoles; Rabbits; Substrate Specificity; Sulfhydryl Reagents; Tiopronin; Zinc | 1985 |
Inhibition of the oxidation of the urinary bladder carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine by pyrazole and 4-substituted pyrazoles.
Topics: Animals; Butylhydroxybutylnitrosamine; Fomepizole; In Vitro Techniques; Liver; Male; NAD; Nitrosamines; Oxidation-Reduction; Pyrazoles; Rats; Rats, Inbred Strains; Urinary Bladder | 1988 |
Increased sensitivity of the microsomal oxidation of ethanol to inhibition by pyrazole and 4-methylpyrazole after chronic ethanol treatment.
Topics: Animals; Cytochrome P-450 Enzyme System; Ethanol; Fomepizole; Male; Methylcholanthrene; Microsomes; Oxidation-Reduction; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains | 1987 |
Rat liver microsomal induction of the oxidation of drugs and alcohols, and sodium dodecyl sulfate-gel profiles after in vivo treatment with pyrazole or 4-methylpyrazole.
Topics: Alcohols; Aminopyrine; Aniline Compounds; Animals; Butanols; Coumarins; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Ethanol; Fomepizole; Isoenzymes; Kinetics; Male; Microsomes, Liver; Molecular Weight; Oxidation-Reduction; Pharmaceutical Preparations; Pyrazoles; Rats; Rats, Inbred Strains; Sodium Dodecyl Sulfate; Stereoisomerism | 1986 |
Inhibition of microsomal oxidation of ethanol by pyrazole and 4-methylpyrazole in vitro. Increased effectiveness after induction by pyrazole and 4-methylpyrazole.
Topics: Animals; Dimethyl Sulfoxide; Ethanol; Fomepizole; Kinetics; Male; Microsomes, Liver; Oxidation-Reduction; Pyrazoles; Rats; Rats, Inbred Strains; Spectrophotometry | 1986 |
Pyrazole and 4-methylpyrazole inhibit oxidation of ethanol and dimethyl sulfoxide by hydroxyl radicals generated from ascorbate, xanthine oxidase, and rat liver microsomes.
Topics: Animals; Ascorbic Acid; Dimethyl Sulfoxide; Ethanol; Fomepizole; Free Radicals; Hydroxides; Hydroxyl Radical; Kinetics; Male; Microsomes, Liver; Oxidation-Reduction; Pyrazoles; Rats; Rats, Inbred Strains; Xanthine Oxidase | 1982 |
Reduction in voluntary ethanol consumption by treatment with alcohol dehydrogenase inhibitors.
Topics: Alcohol Drinking; Alcohol Oxidoreductases; Animals; Fomepizole; Male; Pyrazoles; Rats; Rats, Inbred Strains; Taste | 1980 |
Differences in teratogenic and toxic properties of alcohol dehydrogenase inhibitors pyrazole and 4-methylpyrazole in Drosophila melanogaster: I. ADH allozymes in variable genetic backgrounds.
Topics: Acetates; Alcohol Dehydrogenase; Animals; Drosophila melanogaster; Drug Synergism; Female; Fomepizole; Larva; Male; Pyrazoles | 1995 |
Differences in teratogenic and toxic properties of alcohol dehydrogenase inhibitors pyrazole and 4-methylpyrazole in Drosophila melanogaster: II. Adh allozymes in an isogenic background.
Topics: Abnormalities, Drug-Induced; Alcohol Dehydrogenase; Animals; Chromosome Mapping; Drosophila melanogaster; Female; Fomepizole; Genetic Variation; Isoenzymes; Male; Pyrazoles | 1994 |
Characterization of pyrazole and 4-methylpyrazole induction of cytochrome P4502E1 in rat kidney.
Topics: Animals; Base Sequence; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Enzyme Induction; Fomepizole; Hydrogen Peroxide; Immunoglobulin G; Kidney; Lipid Peroxidation; Liver; Lung; Male; Microsomes; Molecular Sequence Data; Oxidoreductases, N-Demethylating; Pyrazoles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxides | 1994 |
Induction of liver cytochrome P4502E1 by pyrazole and 4-methylpyrazole in neonatal rats.
Topics: Animals; Animals, Newborn; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Enzyme Induction; Female; Fomepizole; Liver; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Pregnancy; Pyrazoles; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1993 |
Induction of CYP2A5 by pyrazole and its derivatives in mouse primary hepatocytes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Enzyme Induction; Enzyme Inhibitors; Fomepizole; L-Lactate Dehydrogenase; Liver; Male; Mice; Mice, Inbred DBA; Mixed Function Oxygenases; Pyrazoles | 1998 |
In vitro studies of human alcohol dehydrogenase inhibition in the process of methanol and ethylene glycol oxidation.
Topics: Alcohol Dehydrogenase; Cimetidine; Enzyme Inhibitors; Ethylene Glycol; Fomepizole; Humans; In Vitro Techniques; Liver; Methanol; Methylene Blue; Pyrazoles; Theophylline | 1998 |
Inhibition of 1,4-butanediol metabolism in human liver in vitro.
Topics: Adult; Aged; Antidotes; Butylene Glycols; Cimetidine; Disulfiram; Drug Interactions; Ethanol; Female; Fomepizole; Gas Chromatography-Mass Spectrometry; Humans; Hydroxybutyrates; In Vitro Techniques; Liver; Male; Middle Aged; Pyrazoles | 2011 |
Inhibition of CYP2E1 leads to decreased malondialdehyde-acetaldehyde adduct formation in VL-17A cells under chronic alcohol exposure.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Allyl Compounds; Apoptosis; Caspase 3; Cell Line; Cell Survival; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Drug Administration Schedule; Enzyme Inhibitors; Ethanol; Fomepizole; Hep G2 Cells; Humans; Malondialdehyde; Pyrazoles; Reactive Oxygen Species; Sulfides | 2013 |