fomepizole and ketoconazole

fomepizole has been researched along with ketoconazole in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (71.43)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Frosini, M; Fusi, F; Pessina, F; Sgaragli, GP; Tipton, KF; Valoti, M1
Gottesdiener, KM; Kari, PP; Marbury, T; Miller, JL; Mistry, GC; Rodrigues, AD; Simpson, RC; Wagner, JA; Winchell, GA1
Chang, JH; Kochansky, CJ; Shou, M1
Bajrami, B; Krishnan, S; Rusling, JF1
Liu, ZH; Zeng, S1

Reviews

1 review(s) available for fomepizole and ketoconazole

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for fomepizole and ketoconazole

ArticleYear
The effect of ketoconazole on the pharmacokinetics of a selective alpha 1A-adrenoceptor antagonist.
    Journal of clinical pharmacology, 2005, Volume: 45, Issue:6

    Topics: Administration, Oral; Adrenergic alpha-1 Receptor Antagonists; Adult; Area Under Curve; Carbon Radioisotopes; Coumarins; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Fomepizole; Half-Life; Humans; Ketoconazole; Male; Microsomes, Liver; Pyrazoles; Pyrimidinones; Quinidine; Receptors, Adrenergic, alpha-1; Sulfaphenazole; Theophylline

2005

Other Studies

5 other study(ies) available for fomepizole and ketoconazole

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Cytochrome P450-dependent N-dealkylation of L-deprenyl in C57BL mouse liver microsomes: effects of in vivo pretreatment with ethanol, phenobarbital, beta-naphthoflavone and L-deprenyl.
    European journal of pharmacology, 2000, Mar-17, Volume: 391, Issue:3

    Topics: Animals; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disulfiram; Enzyme Induction; Enzyme Inhibitors; Ethanol; Fomepizole; In Vitro Techniques; Isoenzymes; Ketoconazole; Mice; Mice, Inbred C57BL; Microsomes, Liver; Monoamine Oxidase Inhibitors; NADH, NADPH Oxidoreductases; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Pyrazoles; Selegiline

2000
The role of P-glycoprotein in the bioactivation of raloxifene.
    Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:12

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotransformation; Cells, Cultured; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Fomepizole; Glutathione; Hepatocytes; Humans; Ketoconazole; Microsomes, Liver; Naphthalenes; Pyrazoles; Raloxifene Hydrochloride; Verapamil

2006
Microsome biocolloids for rapid drug metabolism and inhibition assessment by LC-MS.
    Drug metabolism letters, 2008, Volume: 2, Issue:3

    Topics: Animals; Chromatography, Liquid; Colloids; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Fomepizole; Inhibitory Concentration 50; Ketoconazole; Microsomes, Liver; Nanoparticles; Nitroso Compounds; Pyrazoles; Rats; Tandem Mass Spectrometry

2008
Cytotoxicity of ginkgolic acid in HepG2 cells and primary rat hepatocytes.
    Toxicology letters, 2009, Jun-22, Volume: 187, Issue:3

    Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cell Line, Tumor; Cell Survival; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fomepizole; Hepatocytes; Humans; Isoenzymes; Ketoconazole; Liver; Male; Microsomes, Liver; Pyrazoles; Quinine; Rats; Rats, Sprague-Dawley; Salicylates; Sulfaphenazole

2009