folic acid has been researched along with pyrimethamine in 149 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 84 (56.38) | 18.7374 |
| 1990's | 23 (15.44) | 18.2507 |
| 2000's | 23 (15.44) | 29.6817 |
| 2010's | 16 (10.74) | 24.3611 |
| 2020's | 3 (2.01) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Ayeni, O; Esan, GJ; Ogunbode, O; Oluboyede, O | 1 |
| Cavallito, JC; Nichol, CA; Sigel, CW; Woolley, JL | 1 |
| Hansen, HH; Hansen, M; Lau, ME | 1 |
| Flintoff, W; Saya, L | 1 |
| Greydanus, DE; Hofmann, AD; Noble, KG | 1 |
| Apt, W | 1 |
| Wilmanns, W | 1 |
| Rollo, IM | 1 |
| Csóka, R; Kullmann, L; Magyar, E; Vass, M | 1 |
| Girdwood, RH | 1 |
| Iváldy, G; Páldy, L | 1 |
| Berlinger, R; Diehl, K | 1 |
| Leport, C; Niyongabo, T; Vildé, JL | 1 |
| Lewin, LM; Pholpramool, C; Ruchirawat, S; Verawatnapakul, V | 1 |
| Alvarez, R; Gatell, JM; González-Clemente, JM; Graus, F; Guelar, A; Jiménez de Anta, MT; Mallolas, J; Mercader, JM; Miró, JM; Pedrol, E | 1 |
| Bates, CJ; Bradley, AK; Fuller, NJ; Greenwood, AM; Greenwood, BM; Hayes, RJ; Tulloch, S | 1 |
| Bunni, M; Dilwith, R; Galivan, J; Johnson, TB; Nair, MG; Priest, DG; Rhee, MS | 1 |
| Jankó, M; Juhász, P; Tóth, L; Vukmirovits, G | 1 |
| Galivan, J; Nimec, Z; Rotundo, R | 1 |
| Krungkrai, J; Webster, HK; Yuthavong, Y | 1 |
| Mines, LS; Sirotnak, FM; Yang, CH | 1 |
| Galivan, J; Nimec, Z; Rhee, M | 1 |
| Boschelli, D; Galivan, J; Kerwar, SS; Nimec, Z; Oronsky, AL; Rhee, M | 1 |
| Davis, RE | 1 |
| Brockelman, CR; Menabandhu, C; Tan-ariya, P | 1 |
| Morrison, JF; Stone, SR | 1 |
| Walter, RD | 1 |
| Rosenberg, IH; Selhub, J; Zimmerman, J | 1 |
| Chulay, JD; Sixsmith, DG; Spencer, HC; Watkins, WM | 1 |
| Panijpan, B; Ruenwongsa, P; Sirawaraporn, W; Yuthavong, Y | 1 |
| Akintunde, A; Attai, ED; Bartlett, A; Bidwell, DE; Bradley, AK; Bradley-Moore, AM; Fleming, AF; Greenwood, BM; Kirkwood, BR; Voller, A | 1 |
| Adcock, KJ; Adeshina, H; Akene, J; Cooke, AR; McFAarlane, H; Reddy, S | 1 |
| Sirotnak, FM | 1 |
| Gilles, HM; Lesi, F; Odutola, A; Ransome-Kuti, O; Ransome-Kuti, S; Reid, HA | 1 |
| Ferone, R; Hitchings, GH | 1 |
| Jaffe, JJ; McCormack, JJ | 1 |
| Gutteridge, WE; Jaffe, JJ; McCormack, JJ | 1 |
| Robenberg, IH | 1 |
| Ahmed, I; Akinyanju, O; Goddell, JC | 1 |
| Hall, DH; Johnson, JR | 1 |
| Carollo, F; Dardanoni, L; Spanó, C | 1 |
| Harrison, KA; Ibeziako, PA | 1 |
| Goldie, JH; Hill, BT; Price, LA | 1 |
| Heischkeil, R | 1 |
| Arnold, JD; Martin, DC | 1 |
| Gunning, JJ; Strickland, GT; Tong, MJ; Votteri, BA | 1 |
| Kostinas, JE; Strickland, GT | 1 |
| Bandarizadeh, B; Dutz, W; Fakouhi, T; Kohout, EE; Post, C | 1 |
| Krug, K | 1 |
| Baugh, CM; Geils, GF; Scott, CW | 1 |
| Lund, E; Lycke, E | 1 |
| Bushby, SR; Reeve, P; Taverne, J | 1 |
| Canfield, CJ; McCormick, GJ; Willet, GP | 1 |
| Castles, TR; Kintner, LD; Lee, CC | 1 |
| Aviado, DM; Matsuo, S; Ruiz, R; Smith, J | 1 |
| Baugh, CM; Gaut, ZN; Solomon, HM | 1 |
| Peters, W | 1 |
| Carlisle, H; Spector, RG | 1 |
| Nano, HD; Plaza, A | 1 |
| Sedan, J | 1 |
| Allan, NC; Fleming, AF; Hendrickse, JP | 1 |
| Topley, E | 1 |
| Herbert, V; Waxman, S | 2 |
| Cuckler, AC; McManus, EC; Oberdick, MT | 1 |
| Holzer, B; Stürchler, D | 1 |
| Diddens, H; Jackson, RC; Niethammer, D | 2 |
| Chulay, JD; Sixsmith, DG; Watkins, WM | 1 |
| Couvreur, J; Desmonts, C | 1 |
| Sirawaraporn, W; Yuthavong, Y | 1 |
| Kozloff, LM; Lute, M | 1 |
| Bustamante, A; Henderson, GB; Patel, R; Rideout, DC | 1 |
| Horvàth, C; Raynaud, F | 1 |
| Bautz, W; Classen, M; Huber, W; Schepp, W | 1 |
| Cardenal, C; Gatell, JM; Guelar, A; Mallolas, J; Miró, JM; Soriano, E; Zamora, L | 1 |
| Bernardi, C; Ducloy, AS; Dufour, P; Fortier, B; Monnier, JC; Plantier, I; Switala, I; Vinatier, D | 1 |
| Kokue, E; Kudo, G; Shimoda, M; Tsunematsu, K | 1 |
| Bagnara, AS; Nott, SE | 1 |
| Kokue, E; Kudo, G; Ohgushi, N; Shimoda, M | 1 |
| Hyde, JE; Read, M; Sims, PF; Wang, P | 1 |
| Christopherson, RI; Rieckmann, KH; Seymour, KK; Yeo, AE | 1 |
| Hyde, JE; Sims, PF; Wang, P | 1 |
| Reynolds, MG; Roos, DS | 1 |
| Bourée, P; Dumazedier, D; Magdeleine, C; Sobesky, G | 1 |
| Bain, FT; Hinchcliff, KW; Messer, NT; Mrad, DR; Sellers, RS; Toribio, RE | 1 |
| Basco, LK; Eldin de Pécoulas, P; Mazabraud, A; Ouatas, T; Tahar, R | 1 |
| Basco, LK; Ringwald, P; Tahar, R | 1 |
| Assaraf, YG; Bunni, M; Drori, S; Jansen, G; Kathmann, I; Mauritz, R; Noordhuis, P; Peters, GJ; Pinedo, HM; Priest, DG; Schornagel, JH; Sprecher, H | 1 |
| Assaraf, YG; Barr, H; Bunni, MA; Jansen, G; Kathmann, I; Noordhuis, P; Peters, GJ; Priest, DG | 1 |
| Brobey, RK; Horii, T; Hyde, JE; Sims, PF; Wang, P | 1 |
| Cody, V; Queener, SF; Rosowsky, A | 1 |
| Bailey, JE; Cheeks, JP; Chou, CC; Colahan, PT; Johnson, M; Jones, GL; Rice, BL; Yang, M | 1 |
| Hinchcliff, KW; Piercy, RJ; Reed, SM | 1 |
| Hyde, JE; Nirmalan, N; Sims, PF; Wang, P | 1 |
| Anghel, G | 1 |
| Assaraf, YG; Goldman, ID; Jansen, G; Rothem, L; Scheffer, GL; Stark, M | 1 |
| SUMMERS, WA | 1 |
| LUCAS, JM | 1 |
| HITCHINGS, GH; WOOD, RC | 2 |
| GILES, CL; JACOBS, L; MELTON, ML | 1 |
| JACOBS, RL | 1 |
| KATASE, RY; LUPOVITCH, A; MCGOWAN, JP | 1 |
| CAPPIO, M | 1 |
| ABRAHAM, JP; TENPAS, A | 1 |
| PULLON, DH | 1 |
| WISE, MF; WOOD, RC | 1 |
| JACKSON, N | 1 |
| HURLY, MG | 1 |
| Cotrim, PC; De Carvalho, PB; Ferreira, EI; Ramos, DC | 1 |
| Aspinall, TV; Hyde, JE; Sims, PF; Wang, P; Wang, Q | 1 |
| Brennan, JD; Brook, MA; Chen, Y; Hodgson, RJ; Long, H; Organ, M; Tleugabulova, D; Zhang, Z; Zhao, X | 1 |
| Barnes, KI; Dzinjalamala, FK; Kublin, JG; Macheso, A; Molyneux, ME; Plowe, CV; Smith, PJ; Taylor, TE | 1 |
| Brennan, JD; Brook, MA; Covey, T; Hodgson, RJ; Kovarik, P | 1 |
| Afonso, R; Cancela, ML; Elandalloussi, LM; Leite, RB; Nunes, PA; Rodrigues, PM | 1 |
| Kokwaro, G; Marsh, K; Nzila, AM; Ward, SA; Winstanley, PA | 1 |
| Balajo, B; Dunyo, S; Greenwood, B; Mbaye, A; Milligan, P; Richardson, K; Shulman, C; Walraven, G | 1 |
| Bennett, S; Fielding, K; Greenwood, B; Malunga, P; Mulenga, M; Shulman, C; Thuma, P | 1 |
| Cabezas-Herrera, J; Navarro-Martínez, MD; Rodríguez-López, JN | 1 |
| Ayisi, JG; Kager, PA; Nahlen, BL; Otieno, JA; Rosen, DH; Shi, YP; Slutsker, L; Steketee, RW; Ter Kuile, FO; van Eijk, AM | 1 |
| Quaye, IK; Sandefur, CI; Sibley, CH; Sirawaraporn, W; Wooden, JM | 1 |
| Diriye, A; Kiara, S; Kokwaro, G; Masseno, V; Mwai, L; Nduati, E; Nzila, A; Ommeh, S | 1 |
| Ayisi, JG; Hamel, MJ; Kager, PA; Kariuki, S; Otieno, K; Ouma, PO; Parise, M; Slutsker, L; Ter Kuile, FO; van Eijk, AM; Williamson, J | 1 |
| Biesma, DH; Bowles, EC; de Jongh, BM; Hillenius, JM; Kortbeek, LM | 1 |
| Irungu, B; Kiboi, D; Langat, B; Nzila, A; Rukunga, G; Wittlin, S | 1 |
| Lanzer, M; Sanchez, CP; Stein, WD | 1 |
| Achan, J; Arinaitwe, E; Clark, TD; Cohan, D; Dorsey, G; Havlir, D; Newman, PM; Rosenthal, PJ; Tumwine, G; Waldman, S; Wanzira, H | 1 |
| Brabin, BJ; D'Alessandro, U; Gies, S; Kalanda, G; Kazembe, P; Msyamboza, K; Savage, E | 1 |
| Gara, SN; Madaki, AJ; Thacher, TD | 1 |
| Caldwell, R; Cox, E; Debrunner, M; Sanchez Mejia, A | 1 |
| Kato, J; Mori, T; Okamoto, S | 1 |
| Carta, A; Cavalli, A; Corona, P; Costi, PM; Ferrari, S; Gibellini, F; Guerrieri, D; Gupta, S; Hannaert, V; Loriga, M; Luciani, R; Michels, PA; Nerini, E; Paglietti, G; Saxena, P | 1 |
| Carlsted, A; Nystrom, L; Urassa, DP | 1 |
| Molloy, AM; Nzila, A; Okombo, J | 1 |
| FRENKEL, JK; HITCHINGS, GH | 1 |
| Chavez-Saldaña, M; Durand-Montaño, C; Gutiérrez-Pérez, O; Rojas-Castañeda, JC; Vigueras-Villaseñor, RM | 1 |
| Kupka, R | 1 |
| Chareanchim, W; Kampeera, J; Kiatpathomchai, W; Kongkasuriyachai, D; Pornthanakasem, W; Rattanajak, R; Yongkiettrakul, S | 1 |
| Accrombessi, M; Cot, M; Moya-Alvarez, V; Ouédraogo, S | 1 |
| Attarha, S; Brown, JI; Burton, FB; Flamand, Y; Frank, DA; Gaetani, M; Heppler, LN; Kanarek, N; Page, BDG; Persaud, R; Petrova, B; Tošić, I; Walker, SR; Wang, P; Yeh, JE; Zubarev, RA | 1 |
| Crider, K; Daniels, K; Finkelstain, J; Green, P; Gutman, J; Mai, C; Mehta, S; Menéndez, C; Moraleda, C; Pons-Duran, C; Qi, YP; Rogers, L; Williams, J; Yeung, L | 1 |
| Dao, D; Fink, G; Koné, S; Probst-Hensch, N; Utzinger, J | 1 |
8 review(s) available for folic acid and pyrimethamine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Usefulness of folinic acid in cytopenia induced by antiparasitic drugs in AIDS patients].
Topics: Acquired Immunodeficiency Syndrome; Drug Therapy, Combination; Folic Acid; Hematologic Diseases; Humans; Leucovorin; Opportunistic Infections; Pneumonia, Pneumocystis; Pyrimethamine; Sulfadiazine; Toxoplasmosis, Cerebral; Trimethoprim, Sulfamethoxazole Drug Combination | 1991 |
Clinical chemistry of folic acid.
Topics: Absorption; Aged; Alcoholism; Anemia, Sickle Cell; Anticonvulsants; Arthritis, Rheumatoid; Biological Assay; Biological Transport; Bone Marrow; Carrier Proteins; Chemical Phenomena; Chemistry; Contraceptives, Oral; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Food Analysis; Formiminoglutamic Acid; Glutamate Formimidoyltransferase; Humans; Hydroxymethyl and Formyl Transferases; Infant; Infant Nutritional Physiological Phenomena; Infant, Newborn; Infections; Kidney Failure, Chronic; Malabsorption Syndromes; Malaria; Methotrexate; Neoplasms; Nervous System Diseases; Nutritional Requirements; Parenteral Nutrition, Total; Pregnancy; Pyrimethamine; Receptors, Cell Surface; Terminology as Topic; Thalassemia; Transferases; Trimethoprim | 1986 |
Biochemical aspects of drug action and resistance in malaria parasites.
Topics: Aminoquinolines; Antimalarials; Chloroquine; Drug Resistance, Microbial; Drug Synergism; Folic Acid; Folic Acid Antagonists; Hemin; Plasmodium; Pyrimethamine; Sulfanilamides | 1985 |
Therapeutic potential of folate uptake inhibition in Plasmodium falciparum.
Topics: Animals; Antimalarials; Drug Combinations; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Folic Acid; Folic Acid Antagonists; Malaria, Falciparum; Plasmodium falciparum; Probenecid; Pyrimethamine; Sulfadoxine | 2004 |
Impact of folate supplementation on the efficacy of sulfadoxine/pyrimethamine in preventing malaria in pregnancy: the potential of 5-methyl-tetrahydrofolate.
Topics: Anencephaly; Animals; Antimalarials; Drug Combinations; Drug Therapy, Combination; Female; Folic Acid; Humans; Malaria; Pregnancy; Pregnancy Complications, Infectious; Pyrimethamine; Sulfadoxine; Tetrahydrofolates; Treatment Outcome | 2014 |
The role of folate in malaria - implications for home fortification programmes among children aged 6-59 months.
Topics: Africa South of the Sahara; Antimalarials; Child, Preschool; Dietary Supplements; Dose-Response Relationship, Drug; Drug Combinations; Folic Acid; Folic Acid Deficiency; Food, Fortified; Humans; Infant; Iron, Dietary; Malaria; Micronutrients; Nutritional Requirements; Observational Studies as Topic; Plasmodium falciparum; Powders; Prevalence; Pyrimethamine; Randomized Controlled Trials as Topic; Recommended Dietary Allowances; Sulfadoxine; Vitamin A; Zinc | 2015 |
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Topics: Anemia; Antimalarials; Birth Weight; Child; Child, Preschool; Dietary Supplements; Female; Folic Acid; Folic Acid Antagonists; Humans; Infant; Infant, Newborn; Iron; Neural Tube Defects; Parasitemia; Pregnancy; Pyrimethamine; Recurrence; Sulfadoxine; Vitamins | 2022 |
12 trial(s) available for folic acid and pyrimethamine
| Article | Year |
|---|---|
The effects of antimalarials and folate supplements on haematological indices and red cell folate levels in Gambian children.
Topics: Antimalarials; Child, Preschool; Dapsone; Drug Combinations; Erythrocyte Indices; Erythrocytes; Folic Acid; Gambia; Hematocrit; Humans; Infant; Leukocyte Count; Placebos; Proguanil; Pyrimethamine | 1988 |
Supplemental folates in the therapy of Plasmodium falciparum malaria.
Topics: Administration, Oral; Anemia; Antimalarials; Blood Platelets; Chloroquine; Clinical Trials as Topic; Folic Acid; Hematocrit; Humans; Leucovorin; Leukocyte Count; Leukopenia; Malaria; Male; Military Medicine; Placebos; Plasmodium falciparum; Pyrimethamine; Sulfisoxazole; Vietnam | 1970 |
Prophylaxis of epidemic infantile pneumocystosis with a 20:1 sulfadoxine+pyrimethamine combination.
Topics: Age Factors; Autopsy; Biopsy; Bone Marrow; Complement Fixation Tests; Female; Folic Acid; Humans; Infant; Infant, Newborn; Male; Placebos; Pneumonia, Pneumocystis; Pyrimethamine; Pyrimidines; Sulfonamides | 1971 |
Common anaemia in rural Gambia. I. Hookworm anaemia among men.
Topics: Adolescent; Adult; Anemia; Folic Acid; Folic Acid Deficiency; Gambia; Hemoglobins; Hookworm Infections; Humans; Iron; Iron-Dextran Complex; Male; Placebos; Pyrimethamine; Rural Health; Vitamin B 12 Deficiency | 1968 |
Effect of sulfadiazine and pyrimethamine on selected physiologic and performance parameters in athletically conditioned thoroughbred horses during an incremental exercise stress test.
Topics: Animals; Antiprotozoal Agents; Blood Cell Count; Blood Glucose; Creatinine; Drug Therapy, Combination; Exercise Test; Female; Folic Acid; Heart Rate; Horses; Male; Oxygen Consumption; Physical Conditioning, Animal; Pyrimethamine; Sulfadiazine; Vitamin B 12 | 2002 |
Blood folate concentrations and in vivo sulfadoxine-pyrimethamine failure in Malawian children with uncomplicated Plasmodium falciparum malaria.
Topics: Analysis of Variance; Biomarkers; Child; Child, Preschool; Drug Therapy, Combination; Enzyme Inhibitors; Female; Folic Acid; Humans; Infant; Malaria, Falciparum; Malawi; Male; Odds Ratio; Pyrimethamine; Sulfadoxine; Tetrahydrofolate Dehydrogenase; Treatment Failure; Treatment Outcome | 2005 |
Lack of inhibition of the anti-malarial action of sulfadoxine-pyrimethamine by folic acid supplementation when used for intermittent preventive treatment in Gambian primigravidae.
Topics: Adolescent; Adult; Anemia; Animals; Antimalarials; Dietary Supplements; Drug Combinations; Female; Folic Acid; Gambia; Gravidity; Hematinics; Hemoglobins; Humans; Malaria, Falciparum; Parasitemia; Pregnancy; Pregnancy Complications, Parasitic; Pyrimethamine; Sulfadoxine | 2006 |
Folic acid treatment of Zambian children with moderate to severe malaria anemia.
Topics: Anemia; Animals; Antimalarials; Atovaquone; Child; Child, Preschool; Drug Combinations; Folic Acid; Hematinics; Humans; Infant; Malaria, Falciparum; Naphthoquinones; Parasitemia; Population Density; Proguanil; Pyrimethamine; Sulfadoxine; Treatment Failure; Zambia | 2006 |
Plasma folate level and high-dose folate supplementation predict sulfadoxine-pyrimethamine treatment failure in pregnant women in Western kenya who have uncomplicated malaria.
Topics: Adult; Animals; Antimalarials; Dietary Supplements; Drug Combinations; Female; Folic Acid; Humans; Kenya; Malaria; Pregnancy; Pregnancy Complications, Parasitic; Pyrimethamine; Risk Factors; Sulfadoxine; Survival Analysis; Treatment Failure; Young Adult | 2008 |
A comparison of iron and folate with folate alone in hematologic recovery of children treated for acute malaria.
Topics: Anemia; Antimalarials; Child, Preschool; Chloroquine; Drug Combinations; Drug Therapy, Combination; Female; Folic Acid; Humans; Infant; Iron; Malaria; Male; Nigeria; Pyrimethamine; Sulfadoxine | 2010 |
Effectiveness of routine antihelminthic treatment on anaemia in pregnancy in Rufiji District, Tanzania: a cluster randomised controlled trial.
Topics: Adult; Albendazole; Anemia; Anemia, Iron-Deficiency; Anthelmintics; Antimalarials; Cluster Analysis; Drug Combinations; Female; Folic Acid; Follow-Up Studies; Gestational Age; Helminthiasis; Hemoglobins; Humans; Iron; Malaria; Postpartum Period; Pregnancy; Pregnancy Complications, Hematologic; Pregnancy Complications, Parasitic; Prenatal Care; Prevalence; Pyrimethamine; Single-Blind Method; Sulfadoxine; Tanzania; Young Adult | 2011 |
Improving coverage of antenatal iron and folic acid supplementation and malaria prophylaxis through targeted information and home deliveries in Côte d'Ivoire: a cluster randomised controlled trial.
Topics: Adolescent; Anemia; Cote d'Ivoire; Dietary Supplements; Drug Combinations; Female; Folic Acid; Humans; Iron; Malaria; Pregnancy; Pyrimethamine; Sulfadoxine | 2023 |
129 other study(ies) available for folic acid and pyrimethamine
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Diagnosis of iron deficiency anaemia among Nigerian pregnant women by serum iron/T.I.B.C. determination.
Topics: Anemia, Hypochromic; Blood Cells; Female; Folic Acid; Folic Acid Deficiency; Humans; Iron; Malaria; Pregnancy; Pregnancy Complications, Hematologic; Pyrimethamine | 1976 |
Lipid-soluble diaminopyrimidine inhibitors of dihydrofolate reductase.
Topics: Administration, Oral; Animals; Brain; Brain Neoplasms; Dogs; Folic Acid; Folic Acid Antagonists; Half-Life; Humans; Leucovorin; Lipid Metabolism; Male; Models, Biological; Pyrimethamine; Pyrimidines; Rats; Solubility; Species Specificity | 1977 |
Unpredictable hematologic toxicity of weekly ddmp.
Topics: Antineoplastic Agents; Drug Administration Schedule; Drug Therapy, Combination; Folic Acid; Hematologic Diseases; Humans; Leucovorin; Middle Aged; Pyrimethamine | 1978 |
The selection of wild-type revertants from methotrexate permeability mutants.
Topics: Animals; Cell Line; Cell Membrane Permeability; Cricetinae; Drug Resistance; Folic Acid; Methotrexate; Mutation; Phenotype; Pyrimethamine; Selection, Genetic; Tetrahydrofolate Dehydrogenase | 1978 |
Chorioretinitis in the adolescent: two case presentations with discussion.
Topics: Adolescent; Child; Chorioretinitis; Diagnosis, Differential; Female; Folic Acid; Humans; Male; Prednisone; Prognosis; Pyrimethamine; Sulfadiazine; Toxoplasma; Visual Acuity | 1977 |
[Treatment of toxoplasmosis (author's transl)].
Topics: Adrenal Cortex Hormones; Animals; Drug Therapy, Combination; Folic Acid; Humans; Mice; Pyrimethamine; Sulfamethoxypyridazine; Sulfonamides; Toxoplasmosis; Toxoplasmosis, Ocular | 1978 |
[Drug induced megaloblastic anemia].
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Antineoplastic Agents; Azathioprine; Bone Marrow; Bone Marrow Cells; DNA; Folic Acid; Folic Acid Antagonists; Humans; Mercaptopurine; Methotrexate; Purines; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates | 1978 |
Antiplasmodial efficacy of 2,4--diaminopyrimidine0sylfonamide combinations, especially against chloroquine-resistant malaria.
Topics: Antimalarials; Chloroquine; Drug Combinations; Drug Evaluation, Preclinical; Drug Resistance, Microbial; Enterococcus faecalis; Folic Acid; Folic Acid Antagonists; History, 20th Century; Humans; Lacticaseibacillus casei; Leucovorin; Malaria; Microbial Sensitivity Tests; Plasmodium falciparum; Pyrimethamine; Pyrimidines; Sulfalene; Sulfonamides; Trimethoprim | 1975 |
Polytenosynovitis caused by Toxoplasma gondii.
Topics: Female; Folic Acid; Humans; Male; Middle Aged; Pyrimethamine; Sulfonamides; Tenosynovitis; Toxoplasma; Toxoplasmosis | 1977 |
The nature of possible adverse reactions to co-trimoxazole.
Topics: Aminopterin; Anemia, Megaloblastic; Chemical Phenomena; Chemistry; Drug Combinations; Folic Acid; Humans; Methotrexate; Pyrimethamine; Sulfamethoxazole; Thrombocytopenia; Trimethoprim; Vitamin B 12 | 1976 |
Treatment of Pneumocystis carinii pneumonia in infancy.
Topics: Dihydroergotoxine; Drug Therapy, Combination; Female; Folic Acid; Humans; Infant; Infant, Newborn; Infant, Premature, Diseases; Male; Pentamidine; Pneumonia, Pneumocystis; Promethazine; Pyrimethamine | 1976 |
[Pyrimethamine-induced megaloblatic anemia in florid toxoplasmosis].
Topics: Adolescent; Anemia, Macrocytic; Anemia, Megaloblastic; Female; Folic Acid; Folic Acid Antagonists; Humans; Iatrogenic Disease; Pyrimethamine; Toxoplasmosis | 1976 |
Mode of action of the antifertility sulphonamides: lack of effects on folate metabolism.
Topics: Animals; Dimethyl Sulfoxide; Drug Combinations; Epididymis; Fertility; Folic Acid; Liver; Male; Prostate; Pyrimethamine; Rats; Rats, Inbred F344; Seminal Vesicles; Sulfacetamide; Sulfamerazine; Sulfanilamide; Sulfanilamides; Sulfisoxazole; Sulfonamides; Trimethoprim | 1990 |
[Encephalic toxoplasmosis in patients with the acquired immunodeficiency syndrome. A clinico-radiological study and the therapeutic results in 78 cases].
Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Biopsy; Brain; Brain Diseases; Clindamycin; Drug Therapy, Combination; Folic Acid; HIV-1; Humans; Male; Opportunistic Infections; Prospective Studies; Pyrimethamine; Recurrence; Sulfadiazine; Tomography, X-Ray Computed; Toxoplasmosis | 1990 |
The role of cellular folates in the enhancement of activity of the thymidylate synthase inhibitor 10-propargyl-5,8-dideazafolate against hepatoma cells in vitro by inhibitors of dihydrofolate reductase.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Folic Acid; Folic Acid Antagonists; Kinetics; Liver Neoplasms, Experimental; Pyrimethamine; Quinazolines; Rats; Thymidylate Synthase; Trimetrexate | 1989 |
Acute monosymptomatic aseptic meningitis caused by Toxoplasma gondii.
Topics: Acute Disease; Child, Preschool; Drug Combinations; Folic Acid; Humans; Male; Meningitis; Meningitis, Aseptic; Pyrimethamine; Staining and Labeling; Sulfamethoxazole; Toxoplasmosis; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1985 |
The characteristics and consequences of folate depletion in hepatoma cells in vitro by inhibition of dihydrofolate reductase.
Topics: Animals; Cell Division; Folic Acid; Folic Acid Antagonists; Liver Neoplasms, Experimental; Pyrimethamine; Tumor Cells, Cultured | 1989 |
De novo and salvage biosynthesis of pteroylpentaglutamates in the human malaria parasite, Plasmodium falciparum.
Topics: Animals; Chromatography, High Pressure Liquid; Erythrocytes; Folic Acid; Humans; Plasmodium falciparum; Pterins; Pteroylpolyglutamic Acids; Pyrimethamine; Sulfadoxine | 1989 |
Further studies on a novel class of genetic variants of the L1210 cell with increased folate analogue transport inward. Transport properties of a new variant, evidence for increased levels of a specific transport protein, and its partial characterization
Topics: Affinity Labels; Aminopterin; Animals; Biological Transport; Carrier Proteins; Cell Division; Cell Membrane; Cholic Acids; Chromatography; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Folate Receptors, GPI-Anchored; Folic Acid; Genetic Variation; Kinetics; Leukemia L1210; Methotrexate; Molecular Weight; Pyrimethamine; Receptors, Cell Surface; Succinimides | 1988 |
Synergistic growth inhibition of rat hepatoma cells exposed in vitro to N10-propargyl-5,8-dideazafolate with methotrexate or the lipophilic antifolates trimetrexate or metoprine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Deoxyuridine; Folic Acid; Folic Acid Antagonists; Liver Neoplasms, Experimental; Methotrexate; Pyrimethamine; Quinazolines; Rats; Thymidine; Thymidylate Synthase; Trimetrexate | 1987 |
Antifolate drug interactions: enhancement of growth inhibition due to the antipurine 5,10-dideazatetrahydrofolic acid by the lipophilic dihydrofolate reductase inhibitors metoprine and trimetrexate.
Topics: Acyltransferases; Animals; Drug Synergism; Folic Acid; Folic Acid Antagonists; Hydroxymethyl and Formyl Transferases; Liver Neoplasms, Experimental; Phosphoribosylglycinamide Formyltransferase; Pyrimethamine; Quinazolines; Tetrahydrofolates; Thymidine Monophosphate; Trimetrexate; Tumor Cells, Cultured | 1988 |
Optimal concentration of p-aminobenzoic acid and folic acid in the in vitro assay of antifolates against Plasmodium falciparum.
Topics: 4-Aminobenzoic Acid; Aminobenzoates; Animals; Culture Media; Drug Interactions; Drug Resistance; Folic Acid; Plasmodium falciparum; Pyrimethamine; Sulfadoxine; Sulfanilamides | 1987 |
Mechanism of inhibition of dihydrofolate reductases from bacterial and vertebrate sources by various classes of folate analogues.
Topics: Animals; Binding, Competitive; Chickens; Escherichia coli; Folic Acid; Folic Acid Antagonists; Leucovorin; Liver; Methotrexate; NADP; Pteridines; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim | 1986 |
Altered dihydrofolate reductase in pyrimethamine-resistant Plasmodium falciparum.
Topics: Animals; Drug Resistance; Folic Acid; Folic Acid Antagonists; Kinetics; Plasmodium falciparum; Pyrimethamine; Tetrahydrofolate Dehydrogenase | 1986 |
Competitive inhibition of folate absorption by dihydrofolate reductase inhibitors, trimethoprim and pyrimethamine.
Topics: Animals; Binding Sites; Biological Transport; Folic Acid; Folic Acid Antagonists; Intestinal Absorption; Intestine, Small; Jejunum; Kinetics; Male; Pyrimethamine; Rats; Rats, Inbred Strains; Trimethoprim | 1987 |
Antagonism of sulfadoxine and pyrimethamine antimalarial activity in vitro by p-aminobenzoic acid, p-aminobenzoylglutamic acid and folic acid.
Topics: 4-Aminobenzoic Acid; Aminobenzoates; Animals; Dose-Response Relationship, Drug; Folic Acid; Glutamates; Plasmodium falciparum; Pyrimethamine; Sulfadoxine; Sulfanilamides | 1985 |
A comparison of chloroquine and pyrimethamine as malaria chemoprophylactics in young Nigerian children.
Topics: Antibodies; Chloroquine; Enzyme-Linked Immunosorbent Assay; Ferritins; Folic Acid; Hemodynamics; Humans; Infant; Malaria; Pyrimethamine; Vomiting | 1985 |
Immunity, transferrin, and survival in kwashiorkor.
Topics: Child, Preschool; Chloroquine; Diet Therapy; Dietary Proteins; Female; Folic Acid; gamma-Globulins; Humans; Immunoglobulins; Infant; Infections; Iron; Kwashiorkor; Male; Pyrimethamine; Serum Albumin; Transferrin; Uric Acid; Vitamins | 1970 |
Two different effects of mutation on the binding of folate antagonists by a microbial dihydrofolate reductase.
Topics: Amines; Amino Acids; Aminopterin; Binding Sites; Cell-Free System; Folic Acid; Folic Acid Antagonists; Genes; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Mutation; NADP; Pteridines; Pyrimethamine; Pyrimidines; Species Specificity; Streptococcus pneumoniae; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1973 |
Arvin treatment for sickle-cell crisis.
Topics: Adolescent; Anemia, Sickle Cell; Anticoagulants; Blood Coagulation Tests; Child; Child, Preschool; Female; Fibrinogen; Folic Acid; Hematuria; Humans; Infant; Male; Pyrimethamine | 1968 |
Resistant falciparum malaria.
Topics: Asia, Southeastern; Drug Resistance, Microbial; Folic Acid; Humans; Malaria; Plasmodium falciparum; Pyrimethamine; South America; Sulfonamides | 1969 |
Folate cofactor biosynthesis by Plasmodium berghei. Comparison of folate and dihydrofolate as substrates.
Topics: Folic Acid; Leucovorin; NADP; Plasmodium; Pyrimethamine; Tetrahydrofolate Dehydrogenase | 1966 |
Dihydrofolate reductase from Trypanosoma equiperdum. I. Isolation, partial purification, and properties.
Topics: Aminopterin; Animals; Folic Acid; Folic Acid Antagonists; Hot Temperature; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Methotrexate; NAD; NADP; Pyrimethamine; Rats; Tetrahydrofolate Dehydrogenase; Trypanosoma | 1967 |
Presence and properties of dihydrofolate reductases within the genus Crithidia.
Topics: Animals; Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Kinetics; Methotrexate; NADP; Pteridines; Pyrimethamine; Pyrimidines; Tetrahydrofolate Dehydrogenase; Trypanosoma | 1969 |
Drugs and folic acid absorption.
Topics: Animals; Contraceptives, Oral; Folic Acid; Folic Acid Deficiency; Intestinal Absorption; Methotrexate; Phenytoin; Pyrimethamine; Sulfasalazine; Trimethoprim | 1972 |
Pyrimethamine poisoning.
Topics: Anemia, Macrocytic; Ataxia; Blindness; Central Nervous System; Child, Preschool; Deafness; Female; Fever; Folic Acid; Folic Acid Antagonists; Humans; Infant; Intellectual Disability; Leucovorin; Male; Pyrimethamine | 1973 |
Isolation and characterization of mutants of bacteriophage T4 resistant to folate analogs.
Topics: Coliphages; Culture Media; Drug Resistance, Microbial; Escherichia coli; Folic Acid; Hot Temperature; Mutation; Osmotic Fragility; Phenotype; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim | 1973 |
[Considerations on some cases of repeated abortions probabily due to Toxoplasma gondii (author's transl)].
Topics: Abortion, Habitual; Adult; Antibody Formation; Drug Therapy, Combination; Female; Folic Acid; Humans; Infant, Newborn; Leucomycins; Oxytetracycline; Pregnancy; Pregnancy Complications, Infectious; Pyrazines; Pyrimethamine; Skin Tests; Sulfanilamides; Toxoplasma; Toxoplasmosis; Toxoplasmosis, Congenital; Vitamins | 1972 |
Maternal anaemia and fetal birthweight.
Topics: Anemia; Anemia, Sickle Cell; Birth Weight; Blood Transfusion; Body Height; Chloroquine; Embryonic and Fetal Development; Female; Fetal Death; Folic Acid; Folic Acid Deficiency; Gestational Age; Hematocrit; Hemoglobinopathies; Humans; Malaria; Pregnancy; Pregnancy Complications; Pyrimethamine; Socioeconomic Factors | 1973 |
Studies concerned with overcoming resistance to methotrexate: a comparison of the effects of methotrexate and 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (BW50197) on the colony forming ability of L5178Y cells.
Topics: Animals; Cell Line; Chlorobenzenes; Diamines; Folic Acid; Folic Acid Antagonists; Leukemia, Experimental; Methotrexate; Mice; Pyrimethamine; Pyrimidines | 1973 |
[Antimetabolites of folic acid metabolism with chemotherapeutic activity against rodent malaria (Plasmodium vinckei)].
Topics: Aminopterin; Animals; Cycloheximide; Female; Folic Acid; Folic Acid Antagonists; Hydantoins; Malaria; Male; Methotrexate; Mice; Mice, Inbred Strains; Phenobarbital; Phenytoin; Plasmodium; Primidone; Pyrimethamine; Thalidomide; Triamterene | 1973 |
Enhanced sensitivity of P. falciparum to sulphalene as a consequence of resistance to pyrimethamine.
Topics: Drug Resistance, Microbial; Folic Acid; Humans; Malaria; Male; Plasmodium falciparum; Pyrimethamine; Sulfonamides | 1969 |
Folic acid deficiency complicating malaria.
Topics: Anemia, Macrocytic; Bone Marrow Examination; Diet; Erythrocyte Count; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Humans; Malabsorption Syndromes; Malaria; Male; Naval Medicine; Plasmodium falciparum; Plasmodium vivax; Pyrimethamine; Reticulocytes; Sulfisoxazole; Vietnam | 1970 |
[Pancytopenia following pyrimethamine treated to toxoplasmosis].
Topics: Adult; Anemia, Aplastic; Female; Folic Acid; Folic Acid Deficiency; Hemorrhagic Disorders; Humans; Pregnancy; Pregnancy Complications, Hematologic; Pyrimethamine; Toxoplasmosis | 1971 |
Treatment of meningeal leukemia with pyrimethamine.
Topics: Adult; Brain Diseases; Folic Acid; Hallucinations; Humans; Leukemia, Myeloid, Acute; Male; Meninges; Mental Disorders; Pyrimethamine; Recurrence; Remission, Spontaneous; Thrombocytopenia | 1971 |
Studies on the reproduction of Toxoplasma gondii in a cell culture system. Inhibition or stimulation of growth by changes in the p-aminobenzoic acid and the folic acid metabolism.
Topics: Aminobenzoates; Aminopterin; Culture Techniques; Folic Acid; HeLa Cells; Leucovorin; Pyrimethamine; Sulfonamides; Toxoplasma | 1966 |
Inhibition by pyrimidine analogues of the synthesis of folic acid by trachoma agents.
Topics: Animals; Chick Embryo; Chlamydia; Culture Techniques; Drug Synergism; Folic Acid; Leucovorin; Pyrimethamine; Pyrimidines; Sulfonamides; Tetrahydrofolate Dehydrogenase | 1968 |
Plasmodium knowlesi: in vitro evaluation of antimalarial activity of folic acid inhibitors.
Topics: Aminobenzoates; Animals; Antimalarials; Carbon Isotopes; Cattle; DNA; Folic Acid; Folic Acid Antagonists; Leucovorin; Orotic Acid; Plasmodium; Pyrazines; Pyrimethamine; Pyrimidines; RNA; Sulfonamides; Triazines | 1971 |
The effects of folic or folinic acid on the toxicity of pyrimethamine in dogs.
Topics: Animals; Blood Chemical Analysis; Body Weight; Dogs; Drug Combinations; Female; Folic Acid; Hemodynamics; Leucovorin; Male; Organ Size; Poisoning; Pyrimethamine | 1971 |
Cardiopulmonary effects of antimalarial drugs. 3. Diaminopyrimidines: trimethoprim (WR 5949) and 5-piperonyl-2,4-diaminopyrimidine (WR 40,070).
Topics: Action Potentials; Anilides; Animals; Antimalarials; Blood Pressure; Cardiac Output; Chloroform; Electrocardiography; Extracorporeal Circulation; Folic Acid; Folic Acid Antagonists; Heart; Heart Ventricles; Membrane Potentials; Mice; Muscle Contraction; Myocardium; Norepinephrine; Plasmodium; Pyrimethamine; Pyrimidines; Rabbits; Rats; Reserpine; Sulfonic Acids | 1970 |
Accumulation of (3',5'-3H2)folic acid by human blood platelets. Effect of dihydrofolic acid reductase inhibitors.
Topics: Aminopterin; Biological Transport, Active; Blood Platelets; Diffusion; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Methotrexate; Pyrimethamine; Triamterene; Tritium | 1970 |
The chemotherapy of rodent malaria. XII. Substituted tetrahydrofurans, a new chemical family of antimalarials. The action of 2-(p-chlorophenyl)-2-(4-piperidyl)-tetrahydrofuran against Plasmodium berghei and Plasmodium chabaudi.
Topics: Aminobenzoates; Animals; Antimalarials; Chloroquine; Diet; Drug Resistance, Microbial; Drug Synergism; Folic Acid; Furans; Mice; Piperidines; Plasmodium; Pyrimethamine; Quinacrine; Sulfadiazine; Triazines | 1970 |
The effect of anti-metabolites on leptazol induced fits in rats.
Topics: Animals; Antimetabolites; Azathioprine; Brain; Cytarabine; Daunorubicin; Fluorouracil; Folic Acid; Folic Acid Antagonists; Methotrexate; Pentylenetetrazole; Pyrimethamine; Rats; Seizures | 1971 |
[Intoxication with pyrimethamine (daraprim)].
Topics: Child, Preschool; Folic Acid; Humans; Male; Pyrimethamine; Toxoplasmosis | 1967 |
[Sulfadiazine, pyrimethamine, spiramycin and folic acid in congenital toxoplasmosis].
Topics: Folic Acid; Humans; Leucomycins; Pyrimethamine; Sulfadiazine; Toxoplasmosis, Congenital; Toxoplasmosis, Ocular | 1967 |
The prevention of megaloblastic anaemia in pregnancy in Nigeria.
Topics: Anemia, Hypochromic; Anemia, Macrocytic; Female; Folic Acid; Hemolysis; Humans; Malaria; Nigeria; Pregnancy; Pregnancy Complications; Pyrimethamine | 1968 |
Mechanism of pyrimethamine-induced megaloblastosis in human bone marrow.
Topics: Anemia, Macrocytic; Bone Marrow; Bone Marrow Diseases; Chorioretinitis; Culture Techniques; Deoxyuridine; DNA; Erythrocytes; Female; Fluorouracil; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Middle Aged; Nucleotides; Oxidation-Reduction; Pyrimethamine; Thymidine; Tritium | 1969 |
Pyrimethamine effect on folate metabolism.
Topics: Bone Marrow; Bone Marrow Cells; Culture Techniques; Folic Acid; Folic Acid Antagonists; Humans; Malaria; Polycythemia; Pyrimethamine | 1969 |
Response of six strains of Eimeria brunetti to two antagonists of para-aminobenzoic acid.
Topics: Aminobenzoates; Animals; Antiprotozoal Agents; Chickens; Coccidiosis; Drug Synergism; Eimeria; Folic Acid; Folic Acid Antagonists; Pyrimethamine; Sulfonamides | 1967 |
Low serum folate among persons taking Fansidar (pyrimethamine plus sulfadoxine) for prophylaxis of malaria.
Topics: Adolescent; Adult; Aged; Child; Dose-Response Relationship, Drug; Drug Combinations; Female; Folic Acid; Humans; Malaria; Male; Middle Aged; Pyrimethamine; Sulfadoxine; Sulfanilamides | 1980 |
Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
Topics: Antineoplastic Agents; Biological Transport; Burkitt Lymphoma; Cell Line; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leukemia, Lymphoid; Lymphoma; Methotrexate; Osteosarcoma; Pyrimethamine; Quinazolines; Structure-Activity Relationship; T-Lymphocytes; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1983 |
Resistance of human tumor cell lines to antifolates.
Topics: B-Lymphocytes; Biological Transport; Cell Line; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Karyotyping; Methotrexate; Osteosarcoma; Pyrimethamine; Quinazolines; T-Lymphocytes; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1984 |
Synergistic antimalarial activity of pyrimethamine and sulfadoxine against Plasmodium falciparum in vitro.
Topics: 4-Aminobenzoic Acid; Animals; Culture Media; Drug Evaluation, Preclinical; Drug Synergism; Folic Acid; Plasmodium falciparum; Pyrimethamine; Sulfadoxine; Sulfanilamides | 1984 |
[Treatment of congenital toxoplasmosis].
Topics: Antibodies; Child; Child, Preschool; Drug Therapy, Combination; Folic Acid; Humans; Infant; Leucomycins; Methylprednisolone; Prednisone; Pyrimethamine; Sulfadiazine; Toxoplasma; Toxoplasmosis, Congenital | 1983 |
Kinetic and molecular properties of dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant Plasmodium chabaudi.
Topics: Animals; Drug Resistance; Folic Acid; Hydrogen-Ion Concentration; Kinetics; Plasmodium; Pyrimethamine; Temperature; Tetrahydrofolate Dehydrogenase | 1984 |
Dual functions of bacteriophage T4D gene 28 product: structural component of the viral tail baseplate central plug and cleavage enzyme for folyl polyglutamates. II. Folate metabolism and polyglutamate cleavage activity of uninfected and infected Escherich
Topics: Carboxypeptidases; Escherichia coli; Folic Acid; gamma-Glutamyl Hydrolase; Genes, Viral; Pteroylpolyglutamic Acids; Pyrimethamine; Substrate Specificity; T-Phages | 1981 |
Suramin sodium: pronounced effects on methotrexate transport and anti-folate activity in cultured tumor cells.
Topics: Antineoplastic Agents; Biological Transport; Carrier Proteins; Cell Division; Drug Synergism; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms; Pyrimethamine; Receptors, Cell Surface; Suramin; Tumor Cells, Cultured | 1995 |
Folate deficiency and congenital malformations induced by pyrimethamine in the rat.
Topics: Animals; Congenital Abnormalities; Female; Fetus; Folic Acid; Folic Acid Deficiency; Male; Maternal-Fetal Exchange; Pregnancy; Pyrimethamine; Rats; Rats, Wistar | 1994 |
[Pyrimethamine-sulfadiazine resistant cerebral toxoplasmosis in AIDS].
Topics: AIDS-Related Opportunistic Infections; Clindamycin; Dexamethasone; Drug Resistance, Microbial; Drug Therapy, Combination; Folic Acid; Humans; Male; Middle Aged; Pyrimethamine; Sulfadiazine; Tomography, X-Ray Computed; Toxoplasmosis, Cerebral | 1995 |
[Therapeutic alternatives for cases of cerebral toxoplasmosis in patients with AIDS: clarithromycin and atovaquone].
Topics: Adult; AIDS-Related Opportunistic Infections; Animals; Atovaquone; Clarithromycin; Clindamycin; Drug Therapy, Combination; Folic Acid; Humans; Male; Naphthoquinones; Pyrimethamine; Sulfadiazine; Toxoplasma; Toxoplasmosis, Cerebral | 1994 |
[Medullary aplasia during treatment for congenital toxoplasmosis in a twin pregnancy].
Topics: Adult; Anemia, Aplastic; Anemia, Sideroblastic; Cordocentesis; Female; Folic Acid; Folic Acid Deficiency; Humans; Leucovorin; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Trimester, Second; Pregnancy, Multiple; Pyrimethamine; Spiramycin; Sulfadiazine; Toxoplasmosis; Twins | 1993 |
Effects of folic acid on pyrimethamine teratogenesis in rats.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Drug Synergism; Embryo, Mammalian; Female; Folic Acid; Injections, Intraperitoneal; Leucovorin; Mice; Mice, Inbred ICR; Pregnancy; Pyrimethamine; Rats; Rats, Wistar; Teratogens | 1993 |
The toxicity of antifolates in Babesia bovis.
Topics: Animals; Babesia bovis; Folic Acid; Folic Acid Antagonists; Pyrimethamine; Pyrimidines; Quinazolines; Trimethoprim; Trimetrexate | 1993 |
Effects of folic acid and pyrimethamine, a dihydrofolate reductase inhibitor, on intestinal absorption of folates in rats.
Topics: Animals; Chromatography, High Pressure Liquid; Female; Folic Acid; Intestinal Absorption; Pyrimethamine; Rats; Rats, Wistar; Time Factors | 1995 |
Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization.
Topics: Alleles; Animals; Antimalarials; Dihydropteroate Synthase; Drug Antagonism; Drug Combinations; Drug Resistance, Microbial; Folic Acid; Genetic Linkage; Humans; Malaria, Falciparum; Microbial Sensitivity Tests; Plasmodium falciparum; Polymerase Chain Reaction; Pyrimethamine; Recombination, Genetic; Sequence Analysis, DNA; Sulfadoxine; Tetrahydrofolate Dehydrogenase | 1997 |
Effects of folic and folinic acids in the activities of cycloguanil and WR99210 against Plasmodium falciparum in erythrocytic culture.
Topics: Animals; Antimalarials; Atovaquone; Drug Interactions; Folic Acid; Humans; Leucovorin; Naphthoquinones; Plasmodium falciparum; Proguanil; Purine Nucleotides; Pyrimethamine; Pyrimidine Nucleotides; Triazines | 1997 |
A modified in vitro sulfadoxine susceptibility assay for Plasmodium falciparum suitable for investigating Fansidar resistance.
Topics: Animals; Antimalarials; DNA, Protozoan; Dose-Response Relationship, Drug; Drug Combinations; Drug Resistance; Erythrocytes; Folic Acid; Humans; Hypoxanthine; Parasitology; Plasmodium falciparum; Polymerase Chain Reaction; Pyrimethamine; Reproducibility of Results; Sulfadoxine | 1997 |
A biochemical and genetic model for parasite resistance to antifolates. Toxoplasma gondii provides insights into pyrimethamine and cycloguanil resistance in Plasmodium falciparum.
Topics: Alleles; Animals; Binding Sites; Drug Resistance; Escherichia coli; Folic Acid; Folic Acid Antagonists; Genetic Complementation Test; Kinetics; Models, Genetic; Models, Molecular; Mutagenesis, Site-Directed; NAD; Plasmodium falciparum; Proguanil; Pyrimethamine; Recombinant Proteins; Tetrahydrofolate Dehydrogenase; Toxoplasma; Triazines | 1998 |
[Cerebral toxoplasmosis and AIDS in Martinique].
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Drug Therapy, Combination; Female; Folic Acid; Humans; Incidence; Male; Martinique; Middle Aged; Pyrimethamine; Risk Factors; Sexual Behavior; Sulfadiazine; Survival Analysis; Toxoplasmosis, Cerebral | 1997 |
Congenital defects in newborn foals of mares treated for equine protozoal myeloencephalitis during pregnancy.
Topics: Abnormalities, Multiple; Administration, Oral; Animals; Animals, Newborn; Anti-Infective Agents; Bone Marrow; Encephalomyelitis; Female; Folic Acid; Folic Acid Antagonists; Horses; Kidney; Pregnancy; Pregnancy Complications, Parasitic; Protozoan Infections, Animal; Pyrimethamine; Skin Abnormalities; Sulfadiazine; Trimethoprim, Sulfamethoxazole Drug Combination; Vitamin E | 1998 |
Analysis of the Plasmodium vivax dihydrofolate reductase-thymidylate synthase gene sequence.
Topics: Animals; Cloning, Molecular; Drug Resistance; Folic Acid; Genes, Protozoan; Multienzyme Complexes; Nucleic Acid Synthesis Inhibitors; Open Reading Frames; Plasmodium vivax; Protozoan Proteins; Pyrimethamine; Repetitive Sequences, Nucleic Acid; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 1998 |
Surveillance of antifolate-resistant malaria.
Topics: Africa; Animals; Antimalarials; Codon; Dihydropteroate Synthase; Drug Resistance; Folic Acid; Genotype; Humans; Malaria, Falciparum; Phenotype; Plasmodium falciparum; Point Mutation; Pyrimethamine; South America; Sulfadoxine; Tetrahydrofolate Dehydrogenase | 1998 |
A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance.
Topics: Affinity Labels; Biological Transport; Blotting, Northern; Carrier Proteins; Drug Resistance, Neoplasm; Folic Acid; Folic Acid Antagonists; Glutamates; Humans; Kinetics; Leukemia; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Pyrimethamine; Pyrimidines; Reduced Folate Carrier Protein; Structure-Activity Relationship; Tetrahydrofolates; Trimetrexate; Tumor Cells, Cultured | 1998 |
Multiple mechanisms of resistance to polyglutamatable and lipophilic antifolates in mammalian cells: role of increased folylpolyglutamylation, expanded folate pools, and intralysosomal drug sequestration.
Topics: Animals; Cell Division; Cells, Cultured; CHO Cells; Cricetinae; Drug Resistance; Folic Acid; Folic Acid Antagonists; Glucose; Lysosomes; Methotrexate; Peptide Synthases; Proteins; Pteroylpolyglutamic Acids; Pyrimethamine; Tritium | 1999 |
Utilization of exogenous folate in the human malaria parasite Plasmodium falciparum and its critical role in antifolate drug synergy.
Topics: 4-Aminobenzoic Acid; Animals; Antimalarials; Dose-Response Relationship, Drug; Drug Combinations; Drug Resistance; Drug Synergism; Folic Acid; Humans; Malaria, Falciparum; Plasmodium falciparum; Pyrimethamine; Sulfadoxine; Tetrahydrofolate Dehydrogenase | 1999 |
Inhibition of dihydrofolate reductases from Toxoplasma gondii, Pneumocystis carinii, and rat liver by rotationally restricted analogues of pyrimethamine and metoprine.
Topics: Animals; Binding Sites; Computer Simulation; Folic Acid; Folic Acid Antagonists; Liver; Molecular Structure; Oxidoreductases; Pneumocystis; Pyrimethamine; Rats; Serine; Threonine; Toxoplasma | 1999 |
Folate deficiency during treatment with orally administered folic acid, sulphadiazine and pyrimethamine in a horse with suspected equine protozoal myeloencephalitis (EPM).
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Diagnosis, Differential; Dietary Supplements; Drug Therapy, Combination; Encephalomyelitis; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Horse Diseases; Horses; Pyrimethamine; Sulfadiazine | 2002 |
Transcriptional analysis of genes encoding enzymes of the folate pathway in the human malaria parasite Plasmodium falciparum.
Topics: Animals; Antimalarials; Drug Combinations; Erythrocytes; Folic Acid; Glycine Hydroxymethyltransferase; Humans; Malaria, Falciparum; Multienzyme Complexes; Plasmodium falciparum; Protozoan Proteins; Pyrimethamine; Reverse Transcriptase Polymerase Chain Reaction; Sulfadoxine; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Transcription, Genetic | 2002 |
[Clinical and therapy features of ocular toxoplasmosis in patients with HIV-AIDS infection].
Topics: Adolescent; Adult; Animals; Antiprotozoal Agents; Child; Drug Therapy, Combination; Female; Folic Acid; HIV Infections; Humans; Male; Pyrimethamine; Sulfadiazine; Toxoplasmosis, Ocular; Treatment Outcome | 2002 |
Antifolate resistance associated with loss of MRP1 expression and function in Chinese hamster ovary cells with markedly impaired export of folate and cholate.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Division; Cells, Cultured; CHO Cells; Cholates; Cricetinae; Drug Resistance; Flow Cytometry; Fluoresceins; Folic Acid; Humans; Methotrexate; Multidrug Resistance-Associated Proteins; Prostaglandins A; Pyrimethamine; Tritium | 2003 |
The chemotherapeutic efficacy of 2,4-diamino-5-p-chlorophenyl-6-ethylpyrimidine (daraprim) in experimental toxoplasmosis.
Topics: Antimalarials; Folic Acid; Humans; Pyrimethamine; Toxoplasmosis | 1953 |
Toxic effects produced by pyrimethamine in chickens and their antagonism by folic acid.
Topics: Animals; Antimalarials; Chickens; Folic Acid; Humans; Meat; Pyrimethamine | 1958 |
A study of the uptake and degradation of folic acid, citrovorum factor, aminopterin, and pyrimethamine by bacteria.
Topics: Aminopterin; Antimalarials; Bacteria; Folic Acid; Leucovorin; Pyrimethamine | 1959 |
Effect of pyrimethamine on folic acid metabolism in Streptococcus faecalis and Escherichia coli.
Topics: Antimalarials; Enterococcus faecalis; Escherichia coli; Folic Acid; Pyrimethamine | 1959 |
EXPERIMENTAL USE OF FOLINIC ACID IN THE TREATMENT OF TOXOPLASMOSIS WITH PYRIMETHAMINE.
Topics: Eye; Folic Acid; Injections; Injections, Intraperitoneal; Injections, Subcutaneous; Leucovorin; Mice; Pyrimethamine; Research; Statistics as Topic; Toxicology; Toxoplasmosis; Toxoplasmosis, Animal; Toxoplasmosis, Ocular | 1964 |
ROLE OF P-AMINOBENZOIC ACID IN PLASMODIUM BERGHEI INFECTION IN THE MOUSE.
Topics: 4-Aminobenzoic Acid; Aminopterin; Animals; Chloroquine; Folic Acid; Folic Acid Deficiency; Leucovorin; Malaria; Mice; Pharmacology; Plasmodium berghei; Pyrimethamine; Research | 1964 |
DARAPRIM: A FOLIC ACID ANTAGONIST: THE DETECTION OF EARLY TOXICITY.
Topics: Blood Platelets; Drug Therapy; Eye; Folic Acid; Folic Acid Antagonists; Head; Hematocrit; Humans; Neutrophils; Pyrimethamine; Toxicology; Toxoplasmosis; Toxoplasmosis, Ocular | 1964 |
[MASSIVE HEMORRHAGIC SYNDROME IN POLYCYTHEMIA TREATED WITH PYRIMETHAMINE].
Topics: Blood Transfusion; Drug Therapy; Folic Acid; Hemorrhage; Hemorrhagic Disorders; Hemostatics; Humans; Polycythemia; Polycythemia Vera; Pyrimethamine; Toxicology | 1964 |
HEMATOLOGICAL SIDE-EFFECTS OF PYRIMETHAMINE IN THE TREATMENT OF OCULAR TOXOPLASMOSIS.
Topics: Anemia; Anemia, Macrocytic; Blood Platelets; Drug Therapy; Folic Acid; Hemoglobinometry; Humans; Leucovorin; Leukocyte Count; Metabolism; Myocarditis; Pigmentation Disorders; Purpura; Purpura, Thrombocytopenic; Pyrimethamine; Sulfonamides; Thrombocytopenia; Toxicology; Toxoplasmosis; Toxoplasmosis, Ocular | 1965 |
THE TREATMENT OF GLANDULAR TOXOPLASMOSIS.
Topics: Child; Choroiditis; Drug Therapy; Female; Folic Acid; Humans; Lung Diseases; Lymphadenitis; Meningitis; Myocarditis; Pregnancy; Pregnancy Complications; Pregnancy Complications, Infectious; Pyrimethamine; Sulfadiazine; Toxoplasmosis; Toxoplasmosis, Congenital | 1965 |
CONVERSION OF FOLIC ACID DERIVATIVES TO THEIR CONJUGATED FORMS BY CELLS OF STREPTOCOCCUS FAECALIS.
Topics: Amino Acids; Aminopterin; Anti-Bacterial Agents; Antibiotics, Antitubercular; Antimetabolites; Bacteriological Techniques; Dermatologic Agents; Enterococcus faecalis; Folic Acid; Formates; Glutamates; Hydrogen-Ion Concentration; Leucovorin; Metabolism; Methotrexate; Pharmacology; Pigments, Biological; Pyrimethamine; Research | 1965 |
SOME EFFECTS OF PYRIMETHAMINE ON THE HORMONE-TREATED CHICK, WITH SPECIAL REFERENCE TO BLOOD PICTURE AND THE INHIBITION OF OVIDUCT GROWTH.
Topics: Alkaline Phosphatase; Animals; Chickens; Clinical Enzyme Tests; Diet; Erythrocytes; Estradiol; Female; Folic Acid; Folic Acid Deficiency; Growth; Hemoglobins; Humans; L-Lactate Dehydrogenase; Oviducts; Pharmacology; Poultry; Pyrimethamine; Research; Toxicology | 1965 |
Administration of pyrimethamine with folic acid and folinic acids in human malaria.
Topics: Antimalarials; Folic Acid; Humans; Leucovorin; Malaria; Pyrimethamine | 1959 |
Synthesis and in vitro evaluation of potential anti-leishmanial targeted drugs of pyrimethamine.
Topics: Animals; Cells, Cultured; Dextrans; Female; Folic Acid; Leishmania mexicana; Macrophages; Male; Mice; Mice, Inbred BALB C; Prodrugs; Pyrimethamine; Trypanocidal Agents | 2003 |
Transfection studies to explore essential folate metabolism and antifolate drug synergy in the human malaria parasite Plasmodium falciparum.
Topics: Animals; Antimalarials; Dihydropteroate Synthase; Drug Resistance; Drug Synergism; Erythrocytes; Folic Acid; Folic Acid Antagonists; Humans; Plasmids; Plasmodium falciparum; Pyrimethamine; Sulfadoxine; Transfection | 2004 |
Protein-doped monolithic silica columns for capillary liquid chromatography prepared by the sol-gel method: applications to frontal affinity chromatography.
Topics: Buffers; Chromatography, Affinity; Chromatography, Liquid; Ethylene Oxide; Folic Acid; Phase Transition; Porosity; Proteins; Pyrimethamine; Silanes; Silicon Dioxide; Tetrahydrofolate Dehydrogenase; Time Factors; Trimethoprim | 2004 |
Capillary-scale frontal affinity chromatography/MALDI tandem mass spectrometry using protein-doped monolithic silica columns.
Topics: Automation; Binding Sites; Buffers; Chromatography, Affinity; Coumaric Acids; Fluorescein; Folic Acid; Image Interpretation, Computer-Assisted; Osmolar Concentration; Proteins; Pyrimethamine; Sensitivity and Specificity; Silicon Dioxide; Solvents; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tetrahydrofolate Dehydrogenase; Time Factors; Trimethoprim | 2005 |
Shikimate and folate pathways in the protozoan parasite, Perkinsus olseni.
Topics: Animals; Antiprotozoal Agents; Bivalvia; Eukaryota; Folic Acid; Glycine; Glyphosate; Proguanil; Pyrimethamine; Shikimic Acid | 2005 |
Antifolates as antimycotics? Connection between the folic acid cycle and the ergosterol biosynthesis pathway in Candida albicans.
Topics: Antifungal Agents; Candida albicans; Drug Synergism; Ergosterol; Folic Acid; Folic Acid Antagonists; Humans; Ketoconazole; Microbial Sensitivity Tests; Pyrimethamine | 2006 |
Effect of haematinic supplementation and malaria prevention on maternal anaemia and malaria in western Kenya.
Topics: Adult; Anemia; Antimalarials; Drug Combinations; Drug Therapy, Combination; Female; Folic Acid; Hematinics; HIV Seronegativity; HIV Seropositivity; Humans; Iron; Kenya; Malaria; Pregnancy; Pregnancy Complications, Hematologic; Pregnancy Complications, Infectious; Pregnancy Trimester, Third; Prevalence; Pyrimethamine; Sulfadoxine; Treatment Outcome | 2007 |
Pyrimethamine-resistant dihydrofolate reductase enzymes of Plasmodium falciparum are not enzymatically compromised in vitro.
Topics: Animals; Antimalarials; Drug Resistance, Microbial; Folic Acid; Kinetics; NADP; Plasmodium falciparum; Point Mutation; Pyrimethamine; Tetrahydrofolate Dehydrogenase | 2007 |
Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer.
Topics: Aminopterin; Animals; Antimalarials; Antineoplastic Agents; Folic Acid; Folic Acid Antagonists; Inhibitory Concentration 50; Leucovorin; Methotrexate; Molecular Structure; Plasmodium falciparum; Proguanil; Pyrimethamine; Tetrahydrofolates; Triazines; Trimetrexate | 2008 |
[Postnatal ocular toxoplasmosis in a grown woman].
Topics: Coccidiostats; Drug Therapy, Combination; Female; Folic Acid; Humans; Middle Aged; Prednisone; Pyrimethamine; Sulfadiazine; Toxoplasmosis, Ocular; Treatment Outcome | 2009 |
Methotrexate and aminopterin lack in vivo antimalarial activity against murine malaria species.
Topics: Administration, Oral; Aminopterin; Animals; Biological Availability; Enzyme Inhibitors; Female; Folic Acid; Folic Acid Antagonists; Malaria; Methotrexate; Mice; Plasmodium; Plasmodium berghei; Plasmodium chabaudi; Plasmodium yoelii; Pyrimethamine | 2009 |
Virulence and drug resistance in malaria parasites.
Topics: Animals; Antimalarials; Drug Resistance; Folic Acid; Multienzyme Complexes; Parasitic Sensitivity Tests; Plasmodium; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Virulence | 2009 |
Placental malaria among HIV-infected and uninfected women receiving anti-folates in a high transmission area of Uganda.
Topics: Adult; AIDS-Related Opportunistic Infections; Antimalarials; Cross-Sectional Studies; Drug Combinations; Female; Folic Acid; HIV Infections; HIV-1; Humans; Infectious Disease Transmission, Vertical; Malaria, Falciparum; Pregnancy; Pregnancy Complications, Parasitic; Prevalence; Pyrimethamine; Risk Factors; Sulfadoxine; Trimethoprim, Sulfamethoxazole Drug Combination; Uganda; Young Adult | 2009 |
Trends in pregnancy outcomes in Malawian adolescents receiving antimalarial and hematinic supplements.
Topics: Adolescent; Adult; Anemia; Antimalarials; Cross-Sectional Studies; Delivery, Obstetric; Drug Combinations; Female; Ferrous Compounds; Folic Acid; Health Surveys; Hematinics; Hospitals; Humans; Infant, Low Birth Weight; Infant, Newborn; Malaria; Malawi; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Outcome; Prenatal Care; Pyrimethamine; Rural Health Services; Rural Population; Sulfadoxine | 2010 |
Acquired toxoplasmosis after orthotopic heart transplantation in a sulfonamide-allergic patient.
Topics: Adult; Antibiotic Prophylaxis; Antiparasitic Agents; Clindamycin; Drug Hypersensitivity; Folic Acid; Heart Transplantation; Humans; Male; Pyrimethamine; Sulfonamides; Toxoplasmosis | 2011 |
Pancytopenia due to pyrimethamine triggered by transplant-associated microangiopathy after allogeneic bone marrow transplantation.
Topics: Anemia, Hemolytic; Antibiotic Prophylaxis; Antiprotozoal Agents; Bone Marrow Transplantation; Folic Acid; Humans; Male; Pancytopenia; Pyrimethamine; Toxoplasmosis; Young Adult | 2011 |
Structure-based selectivity optimization of piperidine-pteridine derivatives as potent Leishmania pteridine reductase inhibitors.
Topics: Cell Line; Drug Synergism; Fibroblasts; Folic Acid; Humans; Hydrophobic and Hydrophilic Interactions; Leishmania; Leishmania major; Leishmania mexicana; Molecular Docking Simulation; Oxidative Stress; Oxidoreductases; Protein Binding; Pyrimethamine; Structure-Activity Relationship; Trypanocidal Agents | 2012 |
Relative reversal by vitamins (rho-aminobenzoic, folic, and folinic acids) of the effects of sulfadiazine and pyrimethamine on Toxoplasma, mouse and man.
Topics: 4-Aminobenzoic Acid; Animals; Antimalarials; Folic Acid; Leucovorin; Mice; Pyrimethamine; Sulfadiazine; Sulfanilamide; Sulfanilamides; Sulfonamides; Toxoplasma; Vitamin A; Vitamin K; Vitamins | 1957 |
Effect of pyrimethamine treatment on male rat testicular cell population development.
Topics: Animals; Apoptosis; Cell Proliferation; Fertility; Folic Acid; Folic Acid Antagonists; Male; Pyrimethamine; Rats; Rats, Wistar; Seminiferous Epithelium; Sertoli Cells; Spermatogenesis; Testis; Toxoplasmosis | 2014 |
Simple detection of single nucleotide polymorphism in Plasmodium falciparum by SNP-LAMP assay combined with lateral flow dipstick.
Topics: DNA Primers; DNA, Protozoan; Drug Resistance; Folic Acid; Genome, Protozoan; Genotype; Malaria, Falciparum; Mutation; Nucleic Acid Amplification Techniques; Plasmodium falciparum; Polymorphism, Single Nucleotide; Pyrimethamine; Sequence Analysis, DNA; Specimen Handling; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 2017 |
High folate levels are not associated with increased malaria risk but with reduced anaemia rates in the context of high-dosed folate supplements and intermittent preventive treatment against malaria in pregnancy with sulphadoxine-pyrimethamine in Benin.
Topics: Anemia; Benin; Cohort Studies; Dietary Supplements; Drug Combinations; Female; Folic Acid; Humans; Malaria; Pregnancy; Pregnancy Complications, Parasitic; Pyrimethamine; Risk; Sulfadoxine | 2018 |
The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase.
Topics: Anti-Infective Agents; Cell Line, Tumor; Folic Acid; Humans; Proteome; Pyrimethamine; STAT3 Transcription Factor; Tetrahydrofolate Dehydrogenase | 2022 |