fmrfamide and 2-octopamine

YGGFMRFamide, FMRFamide and related peptides potentiate transmission at locust slow motor synapses. Since immunohistochemical evidence points to neurohaemal organs (NHO) as potential sources for endogenous RFamide-like peptides we have applied extracts from the metathoracic NHO, equivalent to 1/3 NHO, to the metathoracic extensor tibiae muscle. NHO-extract depolarizes the muscle fibre and increases its membrane resistance; enhances transmitter release; and increases the amplitude of contraction and the rate of relaxation. These effects are in good qualitative and quantitative agreement with those of YGGFMRFamide (5 X 10(-8) to 10(-7) M). Octopamine which partly acts like YGGFMRFamide cannot account for the NHO-effects.

Topics: Animals; Enkephalin, Methionine; FMRFamide; Grasshoppers; Neuropeptides; Neurosecretory Systems; Octopamine; Synaptic Transmission