fluvoxamine has been researched along with peroxyoxalate* in 1 studies
1 other study(ies) available for fluvoxamine and peroxyoxalate
| Article | Year |
|---|---|
Naphthalene- and anthracene-2,3-dialdehyde as precolumn labelling reagents for primary amines using reversed- and normal-phase liquid chromatography with peroxyoxalate chemiluminescence detection.
Naphthalene-2,3-dialdehyde (NDA) and anthracene-2,3-dialdehyde (ADA) were applied as pre-column labelling reagents for the peroxyoxalate chemiluminescence detection of primary amines. The advantages of these labels are the selective derivatization reaction with primary amines and the good chemiluminescence properties. A serious disadvantage is the formation of cyanide-induced side-products which are major interferences in reversed-phase chromatography. For normal-phase chromatography, the excess of reagent was removed by adding a polar amine after derivatization, with subsequent extraction of the labelled analyte with an apolar solvent. The detection limit for NDA-labelled fluvoxamine, an anti-depressant, was in the low femtomole range in standard solutions and in urine samples. For ADA-labelled analytes difficulties were obtained with linearity in peroxyoxalate chemiluminescence detection, probably owing to oxidation of the derivative by hydrogen peroxide. Topics: Amines; Anthracenes; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Chromatography, Liquid; Fluvoxamine; Half-Life; Humans; Indicators and Reagents; Luminescent Measurements; Naphthalenes; Oxalates; Oximes; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 1990 |