fluvoxamine and methacrylic-acid

In this work, the molecularly imprinted polymer nanoparticles (MIP-NPs) for the selective determination of fluvoxamine have been described. The polymer nanoparticles were synthesized by the polymerization of methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker, 2,2-azobisisobutyronitrile as an initiator and fluvoxamine as a template molecule. The MIP-NPs were characterized using techniques that included Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM). Imprinted fluvoxamine molecules were removed from the polymeric structure using acetonitrile in methanol (2:8; v/v) as the eluting solvent. The linear dynamic range for fluvoxamine was 10-1200 μg L-1. The developed method was successfully applied to the extraction of fluvoxamine in complex biological samples.

Topics: Chromatography, High Pressure Liquid; Cross-Linking Reagents; Fluvoxamine; Humans; Hydrogen-Ion Concentration; Methacrylates; Microscopy, Electron, Scanning; Molecularly Imprinted Polymers; Nanoparticles; Nitriles; Solid Phase Extraction; Solvents; Spectroscopy, Fourier Transform Infrared