flutamide and pioglitazone

flutamide has been researched along with pioglitazone in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (12.50)29.6817
2010's21 (87.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Ekins, S; Williams, AJ; Xu, JJ1
Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Dalvie, D; Loi, CM; Smith, DA1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Aleo, MD; Bonin, PD; Luo, Y; Potter, DM; Swiss, R; Will, Y1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
de Zegher, F; del Rio, L; Enríquez, G; Ibáñez, L; López-Bermejo, A; Valls, C1
de Zegher, F; Díaz, M; Enríquez, G; Ibáñez, L; López-Bermejo, A; Valls, C1
de Zegher, F; del Río, L; Díaz, M; Enríquez, G; Ibáñez, L; López-Bermejo, A2
de Zegher, F; Diaz, M; Ibáñez, L; Lopez-Bermejo, A; Salvador, C; Sánchez-Infantes, D; Sebastiani, G1
Beltran, A; Bladé, C; Correig, X; Díaz, M; Ibañez, L; Mallol, R; Rodriguez, MA; Samino, S; Vinaixa, M; Yanes, O1
Chacón, MR; de Zegher, F; Díaz, M; Ibáñez, L; López-Bermejo, A; Maymó-Masip, E; Salvador, C; Vendrell, J1
de Zegher, F; Dunger, DB; Ibáñez, L; López-Bermejo, A; Ong, KK1
Al Khalifah, RA; Bassilious, E; Dennis, B; Flórez, ID; Neupane, B; Thabane, L1
de Zegher, F; Díaz, M; Gallego-Escuredo, JM; Ibáñez, L; Villarroya, F1

Reviews

2 review(s) available for flutamide and pioglitazone

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
The effectiveness and safety of treatments used for polycystic ovarian syndrome management in adolescents: a systematic review and network meta-analysis protocol.
    Systematic reviews, 2015, Sep-23, Volume: 4

    Topics: Adolescent; Androgen Antagonists; Contraceptives, Oral; Diet; Drug Therapy, Combination; Exercise; Female; Flutamide; Humans; Hypoglycemic Agents; Life Style; Metformin; Mineralocorticoid Receptor Antagonists; Pioglitazone; Polycystic Ovary Syndrome; Research Design; Spironolactone; Systematic Reviews as Topic; Thiazolidinediones; Young Adult

2015

Trials

8 trial(s) available for flutamide and pioglitazone

ArticleYear
Combined low-dose pioglitazone, flutamide, and metformin for women with androgen excess.
    The Journal of clinical endocrinology and metabolism, 2007, Volume: 92, Issue:5

    Topics: Adipose Tissue; Adolescent; Adult; Androgen Antagonists; Body Composition; Body Mass Index; Carotid Arteries; Double-Blind Method; Drug Therapy, Combination; Female; Flutamide; Glucose Tolerance Test; Hormones; Humans; Hyperandrogenism; Hyperinsulinism; Hypoglycemic Agents; Lipids; Metformin; Pioglitazone; Thiazolidinediones; Ultrasonography

2007
Pioglitazone (7.5 mg/day) added to flutamide-metformin in women with androgen excess: additional increments of visfatin and high molecular weight adiponectin.
    Clinical endocrinology, 2008, Volume: 68, Issue:2

    Topics: Adiponectin; Adolescent; Adult; Double-Blind Method; Female; Flutamide; Humans; Hyperandrogenism; Hyperinsulinism; Metformin; Nicotinamide Phosphoribosyltransferase; Pioglitazone; Thiazolidinediones; Young Adult

2008
Low-dose pioglitazone and low-dose flutamide added to metformin and oestro-progestagens for hyperinsulinaemic women with androgen excess: add-on benefits disclosed by a randomized double-placebo study over 24 months.
    Clinical endocrinology, 2009, Volume: 71, Issue:3

    Topics: Adolescent; Androgen Antagonists; Androgens; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; Flutamide; Humans; Hyperinsulinism; Hypoglycemic Agents; Metformin; Pilot Projects; Pioglitazone; Progestins; Thiazolidinediones; Young Adult

2009
Low-dose pioglitazone, flutamide, metformin plus an estro-progestagen for non-obese young women with polycystic ovary syndrome: increasing efficacy and persistent safety over 30 months.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2010, Volume: 26, Issue:12

    Topics: Adolescent; Alanine Transaminase; Androgens; Androstenes; Aspartate Aminotransferases; Blood Glucose; Body Composition; C-Reactive Protein; Cholesterol; Cross-Over Studies; Drug Therapy, Combination; Ethinyl Estradiol; Female; Flutamide; gamma-Glutamyltransferase; Humans; Hydro-Lyases; Insulin; Longitudinal Studies; Metformin; Pioglitazone; Polycystic Ovary Syndrome; Thiazolidinediones; Tunica Intima; Young Adult

2010
Treatment of androgen excess in adolescent girls: ethinylestradiol-cyproteroneacetate versus low-dose pioglitazone-flutamide-metformin.
    The Journal of clinical endocrinology and metabolism, 2011, Volume: 96, Issue:11

    Topics: Abdominal Fat; Adolescent; Androgen Antagonists; Body Composition; Cyproterone Acetate; Drug Combinations; Estrogens; Ethinyl Estradiol; Female; Flutamide; Humans; Hyperandrogenism; Hyperinsulinism; Hypoglycemic Agents; Metformin; Pioglitazone; Thiazolidinediones; Treatment Outcome

2011
Metabolomics reveals reduction of metabolic oxidation in women with polycystic ovary syndrome after pioglitazone-flutamide-metformin polytherapy.
    PloS one, 2011, Volume: 6, Issue:12

    Topics: Abdominal Fat; Biomarkers; Carotid Intima-Media Thickness; Chromatography, Gas; Chromatography, Liquid; Dicarboxylic Acids; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Flutamide; Health; Humans; Linoleic Acid; Lipoproteins; Magnetic Resonance Spectroscopy; Metabolomics; Metformin; Multivariate Analysis; Oxidation-Reduction; Pioglitazone; Polycystic Ovary Syndrome; Spectrometry, Mass, Electrospray Ionization; Thiazolidinediones; Young Adult

2011
Ethinyl estradiol-cyproterone acetate versus low-dose pioglitazone-flutamide-metformin for adolescent girls with androgen excess: divergent effects on CD163, TWEAK receptor, ANGPTL4, and LEPTIN expression in subcutaneous adipose tissue.
    The Journal of clinical endocrinology and metabolism, 2012, Volume: 97, Issue:10

    Topics: Abdominal Fat; Adolescent; Androgen Antagonists; Angiopoietin-Like Protein 4; Angiopoietins; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Body Composition; Cyproterone Acetate; Dose-Response Relationship, Drug; Drug Combinations; Ethinyl Estradiol; Female; Flutamide; Gene Expression; Humans; Hyperandrogenism; Hypoglycemic Agents; Leptin; Metformin; Pioglitazone; Receptors, Cell Surface; Receptors, Tumor Necrosis Factor; Subcutaneous Fat; Thiazolidinediones; TWEAK Receptor

2012
Effects of ethinylestradiol-cyproterone acetate vs. pioglitazone-flutamide-metformin on plasma FGF21 levels in adolescent girls with androgen excess.
    Diabetes & metabolism, 2016, Volume: 42, Issue:3

    Topics: Adolescent; Cyproterone Acetate; Drug Combinations; Ethinyl Estradiol; Female; Fibroblast Growth Factors; Flutamide; Hirsutism; Humans; Hyperandrogenism; Hyperinsulinism; Longitudinal Studies; Metformin; Pioglitazone; Thiazolidinediones

2016

Other Studies

14 other study(ies) available for flutamide and pioglitazone

ArticleYear
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7

    Topics: Glutathione; Pharmacology; Sulfur Radioisotopes

2011
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors

2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Which metabolites circulate?
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5

    Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations

2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
    Hepatology (Baltimore, Md.), 2014, Volume: 60, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Humans; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Severity of Illness Index

2014
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
Hyperinsulinaemic androgen excess in adolescent girls.
    Nature reviews. Endocrinology, 2014, Volume: 10, Issue:8

    Topics: Adolescent; Androgens; Drug Therapy, Combination; Dyslipidemias; Female; Flutamide; Hirsutism; Humans; Hyperandrogenism; Hyperinsulinism; Menstruation Disturbances; Metformin; Obesity; Pioglitazone; Thiazolidinediones

2014