flurbiprofen and sulindac

flurbiprofen has been researched along with sulindac in 37 studies

Research

Studies (37)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (10.81)	18.7374
1990's	1 (2.70)	18.2507
2000's	12 (32.43)	29.6817
2010's	19 (51.35)	24.3611
2020's	1 (2.70)	2.80

Authors

Authors	Studies
Duffy, EM; Jorgensen, WL	1
Anacardio, R; Aureli, L; Cesta, MC; Cruciani, G; De Simone, L; Moriconi, A	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Gozalbes, R; Pineda-Lucena, A	1
Ekins, S; Williams, AJ; Xu, JJ	1
Fujiwara, R; Koga, T; Nakajima, M; Yokoi, T	1
Abdul-Hay, S; Qin, Z; Schiefer, IT; Thatcher, GR; Vanni, M; Wang, H	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Kumar, M; Sinha, VR; Thareja, S	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Buchanan, WW; El-Ghobarey, AF; Macleod, MM; Stephens, WH	1
Gupta, SK; Joshi, S	1
Kendall, MJ; Wilkins, MR; Woods, KL	1
Brown, BL; Hearron, MS; Johnson, JH	1
de Jong, PE; de Zeeuw, D; Donker, AJ; Pratt, JJ; van der Hem, GK; Vriesendorp, R	1
Gibson, KM; Kantoci, D; Leipold, DD; McCracken, JD; Murray, ED; Quiggle, DD; Wechter, WJ	1
Koki, A; Myers, C; Padley, RJ; Pamukcu, R; Wechter, W	1
Belder, D; Husmann, H; Warnke, J	1
Hartnell, NR; Wilson, JP	1
Beher, D; Churcher, I; Clarke, EE; Martin, AC; Nadin, A; Shearman, MS; Wrigley, JD	1
Grzesiak, AL; Matzger, AJ	1
Abdel-Aziz, AA; El-Kamel, AH; El-Subbagh, HI; Fatani, AJ	1
Hu, Y; Le Leu, RK; Martin, JE; Young, GP	2
Chi, X; Tai, HH; Tong, M	1
Borgegard, T; Eriksson, H; Johansson, J; Juréus, A; Klintenberg, R; Li, T; Lundkvist, J; Malinowsky, D; Nord, J; Olsson, F; Parpal, S; Paulsen, K; Radesater, AC; Regner, A; Rosqvist, S; Rotticci, D; Sabirsh, A; Singh, R; Stromberg, K; Waldman, M; Yan, H	1
Blennow, K; Blomqvist, J; Borgegård, T; Juréus, A; Karlström, H; Klintenberg, R; Lundkvist, J; Ottervald, J; Parpal, S; Portelius, E; Rosqvist, S; Strömberg, K; Wanngren, J; Zetterberg, H	1
Chai, MZ; Flanagan, JU; Squire, CJ; Teague, RM; Turnbull, AP; Yosaatmadja, Y	1
Du, G; Fang, Z; Gong, N; Lu, Y; Xing, C; Xing, W; Yu, H; Zhang, B	1

Reviews

2 review(s) available for flurbiprofen and sulindac

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs). Prostaglandins & other lipid mediators, 2011, Volume: 96, Issue:1-4 Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Enzyme Activation; Flurbiprofen; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Hydroxyprostaglandin Dehydrogenases; Indomethacin; Kinetics; Lung Neoplasms; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Signal Transduction; Sulindac; Tissue Inhibitor of Metalloproteinase-1; Up-Regulation	2011

Article

Year

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.

Drug discovery today, 2016, Volume: 21, Issue:4

Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs).

Prostaglandins & other lipid mediators, 2011, Volume: 96, Issue:1-4

Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Enzyme Activation; Flurbiprofen; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Hydroxyprostaglandin Dehydrogenases; Indomethacin; Kinetics; Lung Neoplasms; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Signal Transduction; Sulindac; Tissue Inhibitor of Metalloproteinase-1; Up-Regulation

2011

Trials

3 trial(s) available for flurbiprofen and sulindac

Article	Year
A double-blind, crossover trial of mefenamic acid, sulindac and flurbiprofen in rheumatoid arthritis. Current medical research and opinion, 1979, Volume: 5, Issue:10 Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Female; Flurbiprofen; Humans; Indenes; Male; Mefenamic Acid; Middle Aged; Propionates; Sulindac	1979
The effects of selective and non-selective inhibition of cyclo-oxygenase on frusemide-stimulated natriuresis. International journal of clinical pharmacology, therapy, and toxicology, 1986, Volume: 24, Issue:2 Topics: Adult; Creatinine; Cyclooxygenase Inhibitors; Flurbiprofen; Furosemide; Humans; Indomethacin; Male; Natriuresis; Piroxicam; Stimulation, Chemical; Sulindac; Thiazines	1986
Double-blind comparison of flurbiprofen and sulindac for the treatment of osteoarthritis. The American journal of medicine, 1986, Mar-24, Volume: 80, Issue:3A Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Female; Flurbiprofen; Humans; Indenes; Male; Middle Aged; Osteoarthritis; Propionates; Random Allocation; Sulindac	1986

Other Studies

32 other study(ies) available for flurbiprofen and sulindac

Article	Year
Prediction of drug solubility from Monte Carlo simulations. Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11 Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility	2000
Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach. Journal of medicinal chemistry, 2005, Apr-07, Volume: 48, Issue:7 Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Chemical Phenomena; Chemistry, Physical; Humans; In Vitro Techniques; Interleukin-8; Models, Molecular; Phenylpropionates; Protein Binding; Quantitative Structure-Activity Relationship; Serum Albumin; Stereoisomerism	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22 Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption	2007
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
QSAR-based solubility model for drug-like compounds. Bioorganic & medicinal chemistry, 2010, Oct-01, Volume: 18, Issue:19 Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Camphanes; Comet Assay; DNA Damage; Glucuronides; Glucuronosyltransferase; HEK293 Cells; Hepatocytes; Humans; Kidney	2011
Inhibition of amyloidogenesis by nonsteroidal anti-inflammatory drugs and their hybrid nitrates. Journal of medicinal chemistry, 2011, Apr-14, Volume: 54, Issue:7 Topics: Amyloid beta-Peptides; Amyloidosis; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Humans; Mice; Neurons; Nitrates; Small Molecule Libraries	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Self-organizing molecular field analysis of NSAIDs: assessment of pharmacokinetic and physicochemical properties using 3D-QSPkR approach. European journal of medicinal chemistry, 2012, Volume: 53 Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Computational Biology; Least-Squares Analysis; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Relationship between aldose reductase inhibiting activity and anti-cataract action of various non-steroidal anti-inflammatory drugs. Developments in ophthalmology, 1991, Volume: 21 Topics: Aldehyde Reductase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cataract; Flurbiprofen; Galactose; Lens, Crystalline; Naproxen; Ophthalmic Solutions; Piroxicam; Rats; Sulindac	1991
Reduction of urinary protein and prostaglandin E2 excretion in the nephrotic syndrome by non-steroidal anti-inflammatory drugs. Clinical nephrology, 1986, Volume: 25, Issue:2 Topics: Adult; Anti-Inflammatory Agents; Diclofenac; Dinoprostone; Flurbiprofen; Glomerular Filtration Rate; Humans; Indomethacin; Male; Middle Aged; Nephrotic Syndrome; Prostaglandins E; Proteinuria; Renin; Sulindac	1986
Treatment and survival study in the C57BL/6J-APC(Min)/+(Min) mouse with R-flurbiprofen. Life sciences, 2000, Jan-14, Volume: 66, Issue:8 Topics: Adenomatous Polyposis Coli; Alleles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colon; Colonic Neoplasms; Cyclooxygenase Inhibitors; Female; Flurbiprofen; Mice; Mice, Inbred C57BL; Reverse Transcriptase Polymerase Chain Reaction; Sulindac; Survival Analysis; Ulcer	2000
Proapoptotic anti-inflammatory drugs. Urology, 2001, Volume: 57, Issue:4 Suppl 1 Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Celecoxib; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Flurbiprofen; Humans; Isoenzymes; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Sulfonamides; Sulindac	2001
Directed control of electroosmotic flow in nonaqueous electrolytes using poly(ethylene glycol) coated capillaries. Electrophoresis, 2001, Volume: 22, Issue:4 Topics: Acetonitriles; Benzoic Acid; Buffers; Chemical Phenomena; Chemistry, Physical; Electrolytes; Electrophoresis, Capillary; Flurbiprofen; Ibuprofen; Methanol; Osmosis; Phenylacetates; Polyethylene Glycols; Propionates; Reproducibility of Results; Salicylic Acid; Silicon Dioxide; Solvents; Sulindac; Surface Properties; Water	2001
Replication of the Weber effect using postmarketing adverse event reports voluntarily submitted to the United States Food and Drug Administration. Pharmacotherapy, 2004, Volume: 24, Issue:6 Topics: Adverse Drug Reaction Reporting Systems; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Diflunisal; Epidemiologic Measurements; Flurbiprofen; Humans; Incidence; Piroxicam; Retrospective Studies; Sulindac; Time Factors; United Kingdom; United States; United States Food and Drug Administration	2004
Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism. The Journal of biological chemistry, 2004, Oct-15, Volume: 279, Issue:42 Topics: Allosteric Regulation; Amyloid Precursor Protein Secretases; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Endopeptidases; Flurbiprofen; Kinetics; Ligands; Peptide Fragments; Sulindac	2004
New form discovery for the analgesics flurbiprofen and sulindac facilitated by polymer-induced heteronucleation. Journal of pharmaceutical sciences, 2007, Volume: 96, Issue:11 Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Crystallization; Flurbiprofen; Models, Molecular; Spectrum Analysis, Raman; Sulindac; Thermogravimetry; X-Ray Diffraction	2007
Oral colon targeted delivery systems for treatment of inflammatory bowel diseases: synthesis, in vitro and in vivo assessment. International journal of pharmaceutics, 2008, Jun-24, Volume: 358, Issue:1-2 Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartic Acid; Buffers; Chromatography, High Pressure Liquid; Colon; Cyclodextrins; Drug Carriers; Drug Delivery Systems; Flurbiprofen; Gastrointestinal Transit; Hydrogen-Ion Concentration; Hydrolysis; In Vitro Techniques; Inflammatory Bowel Diseases; Male; Naproxen; Prodrugs; Rats; Sulindac	2008
R-flurbiprofen suppresses distal nonmucin-producing colorectal tumors in azoxymethane-treated rats, without suppressing eicosanoid production. American journal of physiology. Gastrointestinal and liver physiology, 2010, Volume: 298, Issue:6 Topics: Animals; Antineoplastic Agents; Azoxymethane; Carcinogens; Colorectal Neoplasms; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Eicosanoids; Flurbiprofen; Male; Mucins; Rats; Rats, Sprague-Dawley; Sulindac	2010
First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms. The Journal of biological chemistry, 2012, Apr-06, Volume: 287, Issue:15 Topics: Alanine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Azepines; Binding, Competitive; Brain; Carbamates; Cell-Free System; Dibenzazepines; Dipeptides; Drug Interactions; Female; Flurbiprofen; Guinea Pigs; HEK293 Cells; Humans; Imidazoles; Mice; Mice, Inbred C57BL; Piperidines; Protein Binding; Protein Processing, Post-Translational; Pyrans; Pyridines; Pyrimidines; Rats; Receptor, EphA4; Receptor, EphB2; Receptors, Notch; Sulfonamides; Sulindac	2012
Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production. The Journal of biological chemistry, 2012, Sep-21, Volume: 287, Issue:39 Topics: Amyloid; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Flurbiprofen; HEK293 Cells; Humans; Mice; Protein Processing, Post-Translational; Protein Structure, Tertiary; Receptors, Notch; Sulindac	2012
Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3. PloS one, 2012, Volume: 7, Issue:8 Topics: 3-Hydroxysteroid Dehydrogenases; Aldo-Keto Reductase Family 1 Member C3; Anti-Inflammatory Agents, Non-Steroidal; Flufenamic Acid; Flurbiprofen; Hydroxyprostaglandin Dehydrogenases; Ibuprofen; Indomethacin; Meclofenamic Acid; Mefenamic Acid; Naproxen; Sulindac; Tolmetin	2012
Comparing the effects of COX and non-COX-inhibiting NSAIDs on enhancement of apoptosis and inhibition of aberrant crypt foci formation in a rat colorectal cancer model. Anticancer research, 2013, Volume: 33, Issue:9 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Azoxymethane; Colorectal Neoplasms; Cyclooxygenase Inhibitors; Disease Models, Animal; Flurbiprofen; Male; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Sulindac	2013
An Evolving Role of Aqueous Piperazine to Improve the Solubility of Non-Steroidal Anti-Inflammatory Drugs. Journal of pharmaceutical sciences, 2022, Volume: 111, Issue:10 Topics: Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Flurbiprofen; Ibuprofen; Indomethacin; Ketoprofen; Phenylbutazone; Piperazine; Powders; Salts; Solubility; Spectroscopy, Fourier Transform Infrared; Sulindac; Water; X-Ray Diffraction	2022