flurbiprofen and naproxen

flurbiprofen has been researched along with naproxen in 106 studies

Research

Studies (106)

Timeframe	Studies, this research(%)	All Research%
pre-1990	13 (12.26)	18.7374
1990's	16 (15.09)	18.2507
2000's	33 (31.13)	29.6817
2010's	38 (35.85)	24.3611
2020's	6 (5.66)	2.80

Authors

Authors	Studies
Andrews, PR; Craik, DJ; Martin, JL	1
Apiwattanakul, N; Chairoungdua, A; Endou, H; Kanai, Y; Nakajima, N; Sekine, T; Sophasan, S	1
Duffy, EM; Jorgensen, WL	1
Topliss, JG; Yoshida, F	1
Cihlar, T; Ho, ES; Mulato, AS	1
Chang, TK; Ensom, MH; Kiang, TK	1
Caron, G; Ermondi, G	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Bauer, R; Goeters, S; Hempel, B; Imming, P; Krause, E; Lohmann, K; Ramadan, M; Watzer, B	1
Carrupt, PA; Martel, S; Ottaviani, G	1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Fujiwara, R; Koga, T; Nakajima, M; Yokoi, T	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U	1
Kumar, M; Sinha, VR; Thareja, S	1
Atwell, GJ; Brooke, DG; Denny, WA; Flanagan, JU; Hamilton, EJ; Heinrich, D; Jamieson, SM; Owen, PJ; Raynham, T; Rigoreau, LJ; Samlal, SS; Schroeder, E; Silva, S; Soudy, C; Trivier, E; Turnbull, AP	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Brewster, C; Deering-Rice, CE; Reilly, CA; Rose, TM	1
Aytaç, PS; Çetin-Atalay, R; Durmaz, I; Houston, DR; Tozkoparan, B	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Pradalier, A; Vincent, D	1
Goldhaber, P; Hall, CM; Howell, TH; Jeffcoat, MK; Johnson, HG; Odle, BM; Offenbacher, S; Smith, MA; Williams, RC	1
Bidault, R; Haumont, M; Herber, R; Magdalou, J; Siest, G; van Es, H	1
VanArsdel, PP	1
Gupta, SK; Joshi, S	1
Eissens, AC; Franssen, EJ; Frijlink, HW; Lerk, CF; Meijer, DK; Oosting, R	1
Fritz, ME; Green, MD; Mayambala, CS; Odle, BM; Offenbacher, S; Sena, FJ; Smith, MA; van Dyke, TE; Yeh, KC	1
Mayer, JM	1
Atkinson, MH; Buchanan, WW; Fitzgerald, AA; Lussier, A; Tannenbaum, HH	1
Andersch, B; Milsom, I	1
Bartolucci, C; Maître, JM; Mayer, JM; Testa, B	1
Andersch, B; Milsom, I; Sundell, G	1
Denlinger, RH; Elliott, GA; Purmalis, A; VanderMeer, DA	1
Crittenden, N; Fitzpatrick, F; McGee, J; McGuire, J	1
Brown, BL; Johnson, JH; Stiger, TR	1
Ansell, BM; Leak, AM; Richter, MR; St Cyr, CH	1
Buchanan, WW; Kassam, YB	1
Cherie-Ligniere, G; Colamussi, V; Cozzolongo, AC; Frizziero, L; Loizzi, P; Mattara, L; Zorzin, L	1
Boss, G; Maître, JM; Testa, B	1
Whittle, BJ	1
Burry, HC; Siebers, R	1
Chemtob, S; Hanna, N; Lachapelle, P; Orquin, J; Roy, MS; Varma, DR	1
Armstrong, DW; Chen, JR; Rundlett, KL	1
Deridder, G; Evrard, PA; Verbeeck, RK	1
Borgå, B; Borgå, O	1
el-Bary, AA; el-Nabarawi, MA; Mohamed, MI	1
Antonelli, E; Cirino, G; Coata, G; Distrutti, E; Federici, B; Fiorucci, S; Morelli, A; Morelli, O; Renzo, GD; Santucci, L; Soldato, PD	1
Hauer, MJ; Hutzler, JM; Tracy, TS	1
Buchwald, SL; Moradi, WA	1
Lozano, JJ; Pouplana, R; Ruiz, J	1
Dickmann, LJ; Haining, RL; Hummel, MA; Hutzler, JM; Rettie, AE; Tracy, TS	1
Kato, S; Kunikata, T; Miyazawa, T; Takeuchi, K; Tanaka, A	1
Hummel, MA; Hutzler, JM; Kolwankar, D; Tracy, TS	1
Lin, BC; Zhu, XF	1
Dickmann, LJ; Haining, RL; Hummel, MA; Rettie, AE; Tracy, TS	1
Chang, CE; Chen, W; Gilson, MK	1
Breese, E; Del Soldato, P; Mitchell, J; Warner, T; Wood, E; Zacharowski, P	1
Karaman, AI; Polat, O	1
Gyllenhaal, O; Stefansson, M	1
Takahira, Y; Takeuchi, K; Tanaka, A; Yokota, A	1
Hornung, S; Krill, SL; Vippagunta, SR; Wang, Z	1
El-Fayomi, HM; El-Sadek, ME; Lashine, el-SM; Metwally, KA; Yaseen, SH	1
Balchen, M; Gjelstad, A; Pedersen-Bjergaard, S; Rasmussen, KE	1
Ji, H; Peng, SX; Zhang, YH	1
Abdel-Aziz, AA; El-Kamel, AH; El-Subbagh, HI; Fatani, AJ	1
Cárdenas, S; Cruz-Vera, M; Lucena, R; Valcárcel, M	1
Berber, MR; Katoh, M; Minagawa, K; Mori, T; Tanaka, M	1
Fanali, S; Rocco, A	1
Angeletti, M; Censi, R; Di Martino, P; Gashi, Z; Gobetto, R; Malaj, L; Masic, A; Mozzicafreddo, M	1
Higashi, K; Ideura, S; Limwikrant, W; Moribe, K; Waraya, H; Yamamoto, K	1
Higashi, K; Ideura, S; Moribe, K; Waraya, H; Yamamoto, K	1
Aoki, Y; Honjo, H; Iwamoto, K; Uwai, Y	1
Alcudia-León, MC; Cárdenas, S; Lucena, R; Riaño, S; Valcárcel, M	1
Chai, MZ; Flanagan, JU; Squire, CJ; Teague, RM; Turnbull, AP; Yosaatmadja, Y	1
Bouchet, LM; de la Guardia, M; Delgado-Pérez, T; Galian, RE; Pérez-Prieto, J	1
Dong, L; Jurban, BJ; Sharma, NP; Smith, WL	1
Björklund, E; Cipriano, M; Congiu, C; Fowler, CJ; Onnis, V; Wilson, AA	1
Gaš, B; Riesová, M; Svobodová, J; Tošner, Z; Ušelová, K; Zusková, I	1
Dimoglo, A; Erçetin, T; Esiringu, İ; Gülcan, HO; Öz, D; Şahin, MF; Şahin, Y; Ünlü, S	1
Chen, Z; Fan, H; Huang, X; Luo, A; Wan, Q; Wu, X; Zang, L	1
Barbera, L; Gattuso, G; Kohnke, FH; Micali, N; Notti, A; Pappalardo, S; Parisi, MF; Patanè, S; Pisagatti, I; Villari, V	1
Funakami, Y; Kato, Y; Nagai, N; Tanino, T	1
Cacciatore, I; Cerasa, LS; Costantini, E; D'Angelo, C; Di Stefano, A; Eusepi, P; Fornasari, E; Marinelli, L; Pomilio, C; Reale, M; Türkez, H	1
Camacho-Muñoz, D; Kasprzyk-Hordern, B; Thomas, KV	1
Higashi, K; Liu, N; Moribe, K; Ueda, K	1
Donnelly, L; Gorman, SP; Hardy, JG; Irwin, NJ; Jones, DS; McCoy, CP	1
Hachuła, B	1
Canotilho, J; Castro, RAE; Eusébio, MES; Machado, SMT; Maria, TMR	1
Iwaki, M; Kawase, A; Kobayashi, Y; Ogiso, T; Shimada, H; Tanahashi, S	1
Ma, R; Qu, H; Wang, B; Wang, F; Yu, G; Yu, Y	1
Agrawal, NR; Briber, RM; Domszy, R; Fan, X; Hu, N; Koolivand, A; Torres-Luna, C; Wang, NS; Yang, A; Zhu, Y	1
Beller, M; Neumann, H; Sergeev, AG; Spannenberg, A	1
Eichhorn, T; Hey-Hawkins, E; Kaluđerović, GN; Morgan, I; Predarska, I; Saoud, M	1
Khan, SJ; Leusch, FDL; McDonald, JA; Neale, PA; Nghiem, LD; Nguyen, LN; Nguyen, QA; Vu, HP	1
Gorenflo, M; Saur, P; van den Anker, JN; van Dyk, M; Welzel, T; Ziesenitz, VC	1
Habara, M; Haraguchi, T; Ikezaki, H; Kawasaki, I; Kojima, H; Ohkawa, K; Ozeki, M; Uchida, T; Uno, R; Yoshida, M	1
Bai, L; Guo, X; Liu, D; Liu, Y; Ma, Z; Nie, Y; Qiao, X; Shang, P; Wei, B	1

Reviews

7 review(s) available for flurbiprofen and naproxen

Article	Year
UDP-glucuronosyltransferases and clinical drug-drug interactions. Pharmacology & therapeutics, 2005, Volume: 106, Issue:1 Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic	2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Migraine and non-steroidal anti-inflammatory agents]. Pathologie-biologie, 1992, Volume: 40, Issue:4 Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Ergotamine; Flufenamic Acid; Flurbiprofen; Humans; Metoclopramide; Migraine Disorders; Naproxen; ortho-Aminobenzoates; Randomized Controlled Trials as Topic	1992
Stereoselective metabolism of anti-inflammatory 2-arylpropionates. Acta pharmaceutica Nordica, 1990, Volume: 2, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Ibuprofen; Naproxen; Stereoisomerism; Suprofen	1990
The propionic acids. Gastrointestinal toxicity in various species. Toxicologic pathology, 1988, Volume: 16, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Digestive System; Dogs; Fenoprofen; Flurbiprofen; Haplorhini; Ibuprofen; Naproxen; Propionates; Rats; Species Specificity	1988
[A novel class of anti-inflammatory and analgesic drugs--NO-donating NSAIDs]. Yao xue xue bao = Acta pharmaceutica Sinica, 2007, Volume: 42, Issue:4 Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiotonic Agents; Cyclooxygenase Inhibitors; Flurbiprofen; Gastrointestinal Diseases; Humans; Ibuprofen; Naproxen; Nitrates; Nitric Oxide Donors	2007
Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years. Paediatric drugs, 2022, Volume: 24, Issue:6 Topics: Adolescent; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Child; Chronic Disease; Diclofenac; Flurbiprofen; Humans; Ibuprofen; Infant; Ketoprofen; Ketorolac; Meloxicam; Naproxen; Niflumic Acid; Pain	2022

Trials

8 trial(s) available for flurbiprofen and naproxen

Article	Year
[Migraine and non-steroidal anti-inflammatory agents]. Pathologie-biologie, 1992, Volume: 40, Issue:4 Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Ergotamine; Flufenamic Acid; Flurbiprofen; Humans; Metoclopramide; Migraine Disorders; Naproxen; ortho-Aminobenzoates; Randomized Controlled Trials as Topic	1992
A comparison of flurbiprofen and naproxen in the treatment of rheumatoid arthritis: a Canadian multi-centre study. Current medical research and opinion, 1990, Volume: 12, Issue:2 Topics: Adult; Aged; Arthritis, Rheumatoid; Disability Evaluation; Double-Blind Method; Female; Flurbiprofen; Humans; Male; Middle Aged; Multicenter Studies as Topic; Naproxen; Pain Measurement; Randomized Controlled Trials as Topic	1990
A double-blind cross-over study comparing flurbiprofen with naproxen-sodium for the treatment of primary dysmenorrhea. Acta obstetricia et gynecologica Scandinavica, 1989, Volume: 68, Issue:6 Topics: Adult; Double-Blind Method; Dysmenorrhea; Female; Flurbiprofen; Humans; Naproxen; Pain Measurement	1989
The effect of flurbiprofen and naproxen sodium on intra-uterine pressure and menstrual pain in patients with primary dysmenorrhea. Acta obstetricia et gynecologica Scandinavica, 1988, Volume: 67, Issue:8 Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; Flurbiprofen; Humans; Naproxen; Pain; Pressure; Propionates; Uterus	1988
Flurbiprofen versus naproxen in the treatment of rheumatoid arthritis. The American journal of medicine, 1986, Mar-24, Volume: 80, Issue:3A Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Flurbiprofen; Humans; Middle Aged; Naproxen; Propionates; Random Allocation	1986
A multicentre comparison of flurbiprofen and naproxen in rheumatoid arthritis: a four-week study in 118 patients. The Journal of international medical research, 1983, Volume: 11, Issue:2 Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Flurbiprofen; Humans; Male; Middle Aged; Naproxen; Propionates	1983
A comparison of flurbiprofen with naproxen in ankylosing spondylitis. The New Zealand medical journal, 1980, Oct-22, Volume: 92, Issue:670 Topics: Clinical Trials as Topic; Double-Blind Method; Female; Flurbiprofen; Gastrointestinal Diseases; Humans; Male; Naproxen; Propionates; Spondylitis, Ankylosing	1980
Pain control during fixed orthodontic appliance therapy. The Angle orthodontist, 2005, Volume: 75, Issue:2 Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Facial Pain; Female; Flurbiprofen; Humans; Ibuprofen; Male; Naproxen; Orthodontic Appliances; Orthodontics, Corrective; Pain Measurement; Prospective Studies; Surveys and Questionnaires	2005

Other Studies

92 other study(ies) available for flurbiprofen and naproxen

Article	Year
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Molecular pharmacology, 1999, Volume: 55, Issue:5 Topics: Animals; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Carrier Proteins; Oocytes; Xenopus laevis	1999
Prediction of drug solubility from Monte Carlo simulations. Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11 Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility	2000
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:1 Topics: Adenine; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Biological Transport; Carrier Proteins; Humans; Kidney; Organophosphonates; Structure-Activity Relationship	2000
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9 Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Chamazulene carboxylic acid and matricin: a natural profen and its natural prodrug, identified through similarity to synthetic drug substances. Journal of natural products, 2006, Volume: 69, Issue:7 Topics: Achillea; Anti-Inflammatory Agents, Non-Steroidal; Azulenes; Carboxylic Acids; Cycloheptanes; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Germany; Lactones; Matricaria; Molecular Structure; Pharmaceutical Preparations; Prodrugs; Sesquiterpenes; Sesquiterpenes, Guaiane	2006
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities. Journal of medicinal chemistry, 2007, Feb-22, Volume: 50, Issue:4 Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water	2007
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22 Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption	2007
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Camphanes; Comet Assay; DNA Damage; Glucuronides; Glucuronosyltransferase; HEK293 Cells; Hepatocytes; Humans; Kidney	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests	2012
Self-organizing molecular field analysis of NSAIDs: assessment of pharmacokinetic and physicochemical properties using 3D-QSPkR approach. European journal of medicinal chemistry, 2012, Volume: 53 Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Computational Biology; Least-Squares Analysis; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship	2012
3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic Acids: highly potent and selective inhibitors of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3. Journal of medicinal chemistry, 2012, Sep-13, Volume: 55, Issue:17 Topics: 3-Hydroxysteroid Dehydrogenases; Aldo-Keto Reductase Family 1 Member C3; Benzoates; Enzyme Inhibitors; Humans; Hydroxyprostaglandin Dehydrogenases; Models, Molecular; Structure-Activity Relationship	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Inhibition of FAAH, TRPV1, and COX2 by NSAID-serotonin conjugates. Bioorganic & medicinal chemistry letters, 2014, Dec-15, Volume: 24, Issue:24 Topics: Amidohydrolases; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Flurbiprofen; Humans; Serotonin; TRPV Cation Channels	2014
Novel triazolothiadiazines act as potent anticancer agents in liver cancer cells through Akt and ASK-1 proteins. Bioorganic & medicinal chemistry, 2016, Feb-15, Volume: 24, Issue:4 Topics: Antineoplastic Agents; Apoptosis; beta Catenin; Cell Line, Tumor; Cyclin D1; Cytoskeletal Proteins; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; HCT116 Cells; Hepatocytes; Humans; Inhibitory Concentration 50; MAP Kinase Kinase Kinase 5; MCF-7 Cells; Molecular Docking Simulation; Nuclear Proteins; Oxidative Stress; Protein Structure, Secondary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship; Signal Transduction; Thiadiazines; Triazoles	2016
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Effects of NSAIDs on beagle crevicular cyclooxygenase metabolites and periodontal bone loss. Journal of periodontal research, 1992, Volume: 27, Issue:3 Topics: Administration, Oral; Administration, Topical; Alveolar Bone Loss; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dinoprostone; Dogs; Flurbiprofen; Gingival Crevicular Fluid; Ibuprofen; Naproxen; Prostaglandins F; Thromboxane B2	1992
Glucuronidation of 3'-azido-3'-deoxythymidine in human liver microsomes: enzyme inhibition by drugs and steroid hormones. Biochimica et biophysica acta, 1992, Jun-09, Volume: 1139, Issue:1-2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Estrone; Ethinyl Estradiol; Flurbiprofen; Glucuronosyltransferase; Humans; Microsomes, Liver; Naproxen; Phenylpropionates; Probenecid; Testosterone; Zidovudine	1992
Pseudoallergic reactions to nonsteroidal anti-inflammatory drugs. JAMA, 1991, Dec-18, Volume: 266, Issue:23 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Drug Eruptions; Female; Flurbiprofen; Humans; Naproxen	1991
Relationship between aldose reductase inhibiting activity and anti-cataract action of various non-steroidal anti-inflammatory drugs. Developments in ophthalmology, 1991, Volume: 21 Topics: Aldehyde Reductase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cataract; Flurbiprofen; Galactose; Lens, Crystalline; Naproxen; Ophthalmic Solutions; Piroxicam; Rats; Sulindac	1991
The effects of cyclodextrins on the disposition of intravenously injected drugs in the rat. Pharmaceutical research, 1991, Volume: 8, Issue:3 Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; beta-Cyclodextrins; Blood Proteins; Cyclodextrins; Flurbiprofen; Injections, Intravenous; Male; Naproxen; Rats; Rats, Inbred Strains; Tissue Distribution	1991
Inhibition of human periodontal prostaglandin E2 synthesis with selected agents. Agents and actions, 1990, Volume: 29, Issue:3-4 Topics: Arachidonic Acid; Arachidonic Acids; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Dinoprostone; Eicosapentaenoic Acid; Flurbiprofen; Humans; Ibuprofen; Ketoprofen; Meclofenamic Acid; Naproxen; Periodontitis; Periodontium; Vitamin E	1990
Metabolic chiral inversion of anti-inflammatory 2-arylpropionates: lack of reaction in liver homogenates, and study of methine proton acidity. Xenobiotica; the fate of foreign compounds in biological systems, 1988, Volume: 18, Issue:5 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Guinea Pigs; Ibuprofen; Isomerism; Kinetics; Liver; Male; Naproxen; Protons; Rats; Rats, Inbred Strains; Suprofen	1988
Cell damage unmasks 15-lipoxygenase activity in human neutrophils. The Journal of biological chemistry, 1985, Jul-15, Volume: 260, Issue:14 Topics: Acetates; Arachidonate Lipoxygenases; Aspirin; Dose-Response Relationship, Drug; Etodolac; Fluorometry; Flurbiprofen; Humans; Hydroxyeicosatetraenoic Acids; Ibuprofen; L-Lactate Dehydrogenase; Lipoxygenase; Naproxen; Neutrophils; Phenylbutazone	1985
Flurbiprofen is as effective as naproxen in juvenile spondylitis. The Journal of rheumatology, 1986, Volume: 13, Issue:3 Topics: Adolescent; Child; Female; Flurbiprofen; Humans; Male; Naproxen; Propionates; Spondylitis	1986
European experience with flurbiprofen. A new analgesic/anti-inflammatory agent. The American journal of medicine, 1986, Mar-24, Volume: 80, Issue:3A Topics: Aspirin; Drug Evaluation; Europe; Flurbiprofen; Humans; Ibuprofen; Indomethacin; Naproxen; Propionates	1986
High-performance liquid chromatographic separation of the enantiomers of anti-inflammatory 2-arylpropionates: suitability of the method for in vitro metabolic studies. Journal of chromatography, 1984, Sep-21, Volume: 299, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Chromatography, High Pressure Liquid; Drug Stability; Flurbiprofen; In Vitro Techniques; Liver; Naproxen; Propionates; Rats; Stereoisomerism	1984
Arachidonic acid metabolites and the gastro-intestinal toxicity of anti-inflammatory agents. Prostaglandins, 1981, Volume: 21 Suppl Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Cyclooxygenase Inhibitors; Digestive System; Flurbiprofen; Gastric Mucosa; Indomethacin; Intestinal Mucosa; Ketoprofen; Naproxen; Prostaglandins; Rats	1981
Alterations in the electroretinogram of newborn piglets by propionic acid-derivative nonsteroidal antiinflammatory drugs but not by indomethacin and diclofenac. Pediatric research, 1995, Volume: 37, Issue:1 Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Electroretinography; Flurbiprofen; Ibuprofen; Indomethacin; Naproxen; Photoreceptor Cells; Propionates; Prostaglandins; Retina; Swine	1995
Evaluation of the macrocyclic antibiotic vancomycin as a chiral selector for capillary electrophoresis. Chirality, 1994, Volume: 6, Issue:6 Topics: Amino Acid Sequence; Amino Acids; Carbazoles; Carboxylic Acids; Electrophoresis; Flurbiprofen; Hydrogen-Ion Concentration; Molecular Sequence Data; Naproxen; Peptides, Cyclic; Stereoisomerism; Vancomycin	1994
Intravenous microdialysis in the mouse and the rat: development and pharmacokinetic application of a new probe. Pharmaceutical research, 1996, Volume: 13, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Catheterization, Central Venous; Flurbiprofen; Male; Mice; Mice, Inbred Strains; Microdialysis; Naproxen; Online Systems; Rats; Rats, Wistar; Telemetry; Vena Cava, Inferior	1996
Serum protein binding of nonsteroidal antiinflammatory drugs: a comparative study. Journal of pharmacokinetics and biopharmaceutics, 1997, Volume: 25, Issue:1 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Chromatography, High Pressure Liquid; Diclofenac; Female; Fenoprofen; Flurbiprofen; Humans; Ketoprofen; Male; Middle Aged; Naproxen; Protein Binding; Tolmetin	1997
Effect of chemical structure on the release of certain propionic acid derivatives from their dosage forms. Drug development and industrial pharmacy, 1998, Volume: 24, Issue:5 Topics: Capsules; Chemical Phenomena; Chemistry, Physical; Dosage Forms; Drug Compounding; Drug Stability; Drug Storage; Flurbiprofen; Humans; Ibuprofen; Ketoprofen; Molecular Structure; Naproxen; Propionates; Suppositories	1998
Nitric oxide-releasing NSAIDs inhibit interleukin-1beta converting enzyme-like cysteine proteases and protect endothelial cells from apoptosis induced by TNFalpha. Alimentary pharmacology & therapeutics, 1999, Volume: 13, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Caspase Inhibitors; Cell Line; Cysteine Proteinase Inhibitors; DNA Fragmentation; Endothelium, Vascular; Flurbiprofen; Gastric Mucosa; Humans; In Situ Nick-End Labeling; Male; Mice; Naproxen; Nitric Oxide; Peroxidase; Rats; Rats, Wistar	1999
Dapsone activation of CYP2C9-mediated metabolism: evidence for activation of multiple substrates and a two-site model. Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:7 Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Dapsone; Enzyme Activation; Flurbiprofen; Hydroxylation; Models, Chemical; Naproxen; Piroxicam; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Substrate Specificity	2001
Palladium-catalyzed alpha-arylation of esters. Journal of the American Chemical Society, 2001, Aug-22, Volume: 123, Issue:33 Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Bromides; Catalysis; Esters; Flurbiprofen; Lithium; Molecular Structure; Naproxen; Organosilicon Compounds; Palladium; Phosphines	2001
Molecular modelling of the differential interaction between several non-steroidal anti-inflammatory drugs and human prostaglandin endoperoxide H synthase-2 (h-PGHS-2). Journal of molecular graphics & modelling, 2002, Volume: 20, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Computer Graphics; Computer Simulation; Crystallography, X-Ray; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Energy Transfer; Flurbiprofen; Humans; Indomethacin; Isoenzymes; Ketoprofen; Meclofenamic Acid; Mefenamic Acid; Membrane Proteins; Models, Molecular; Naproxen; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides	2002
Polymorphic variants (CYP2C93 and CYP2C95) and the F114L active site mutation of CYP2C9: effect on atypical kinetic metabolism profiles. Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:4 Topics: Alleles; Amino Acid Substitution; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Binding Sites; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Flurbiprofen; Humans; Kinetics; Mutation; Naproxen; Piroxicam; Polymorphism, Genetic; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Structure-Activity Relationship; Substrate Specificity	2002
Pathogenic importance of intestinal hypermotility in NSAID-induced small intestinal damage in rats. Digestion, 2002, Volume: 66, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprostone; Flurbiprofen; Gastrointestinal Motility; Indomethacin; Intestinal Mucosa; Intestine, Small; Male; Naproxen; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Rats; Rats, Sprague-Dawley	2002
Activation of CYP2C9-mediated metabolism by a series of dapsone analogs: kinetics and structural requirements. Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:11 Topics: Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Dapsone; Dealkylation; Flurbiprofen; Hydroxylation; Kinetics; Naproxen; Structure-Activity Relationship; Substrate Specificity	2002
[Chiral separation of naproxen and flurbiprofen by capillary electrophoresis]. Se pu = Chinese journal of chromatography, 2000, Volume: 18, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; beta-Cyclodextrins; Cyclodextrins; Electrophoresis, Capillary; Flurbiprofen; Naproxen; Stereoisomerism	2000
Differential activation of CYP2C9 variants by dapsone. Biochemical pharmacology, 2004, May-15, Volume: 67, Issue:10 Topics: Alleles; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Dapsone; Enzyme Activation; Flurbiprofen; Humans; Hydroxylation; Kinetics; Naproxen; Substrate Specificity	2004
Calculation of cyclodextrin binding affinities: energy, entropy, and implications for drug design. Biophysical journal, 2004, Volume: 87, Issue:5 Topics: Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Benzene; Binding Sites; Butanones; Computer Simulation; Cyclodextrins; Drug Delivery Systems; Drug Design; Energy Transfer; Entropy; Flurbiprofen; Kinetics; Models, Chemical; Models, Molecular; Molecular Conformation; Nabumetone; Naproxen; Resorcinols	2004
NSAIDs increase GM-CSF release by human synoviocytes: comparison with nitric oxide-donating derivatives. European journal of pharmacology, 2005, Jan-31, Volume: 508, Issue:1-3 Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blotting, Western; Cells, Cultured; Cyclic AMP; Cyclic GMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Flurbiprofen; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Indomethacin; Membrane Proteins; Naproxen; Nitric Oxide Donors; Nitroprusside; Phosphodiesterase Inhibitors; Prostaglandin-Endoperoxide Synthases; Purinones; Synovial Membrane; Time Factors	2005
Reversal of elution order for profen acid enantiomers in packed-column SFC on Chiralpak AD. Chirality, 2005, May-15, Volume: 17, Issue:5 Topics: 2-Propanol; Alcohols; Amylose; Butanols; Carbon Dioxide; Cellulose; Chromatography; Chromatography, Supercritical Fluid; Citric Acid; Ethanol; Flurbiprofen; Magnetic Resonance Spectroscopy; Models, Chemical; Naproxen; Pentanols; Phenylcarbamates; Propionates; Silicon Dioxide; Stereoisomerism; Temperature; Ultraviolet Rays	2005
Factors involved in upregulation of inducible nitric oxide synthase in rat small intestine following administration of nonsteroidal anti-inflammatory drugs. Digestive diseases and sciences, 2006, Volume: 51, Issue:7 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Disease Models, Animal; Enterobacteriaceae; Flurbiprofen; Gastrointestinal Motility; Indomethacin; Intestinal Diseases; Intestinal Mucosa; Intestine, Small; Lactones; Male; Naproxen; Nitric Oxide; Nitric Oxide Synthase Type II; Pyrazoles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfones; Time Factors; Up-Regulation	2006
Factors affecting the formation of eutectic solid dispersions and their dissolution behavior. Journal of pharmaceutical sciences, 2007, Volume: 96, Issue:2 Topics: Drug Carriers; Fenofibrate; Flurbiprofen; Griseofulvin; Ibuprofen; Models, Chemical; Molecular Weight; Naproxen; Polyethylene Glycols; Sodium Dodecyl Sulfate; Solubility; Transition Temperature; Water	2007
Non-carboxylic analogues of arylpropionic acids: synthesis, anti-inflammatory activity and ulcerogenic potential. European journal of medicinal chemistry, 2007, Volume: 42, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Ibuprofen; Male; Naproxen; Propionates; Rats; Stomach Ulcer; Structure-Activity Relationship; Thiadiazoles; Thiazoles	2007
Electrokinetic migration of acidic drugs across a supported liquid membrane. Journal of chromatography. A, 2007, Jun-08, Volume: 1152, Issue:1-2 Topics: Acids; Chromatography, Micellar Electrokinetic Capillary; Electrophoresis, Capillary; Flurbiprofen; Gemfibrozil; Heptanol; Hydrogen-Ion Concentration; Ketoprofen; Membranes, Artificial; Naproxen; Pharmaceutical Preparations; Probenecid; Reproducibility of Results; Warfarin	2007
Oral colon targeted delivery systems for treatment of inflammatory bowel diseases: synthesis, in vitro and in vivo assessment. International journal of pharmaceutics, 2008, Jun-24, Volume: 358, Issue:1-2 Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartic Acid; Buffers; Chromatography, High Pressure Liquid; Colon; Cyclodextrins; Drug Carriers; Drug Delivery Systems; Flurbiprofen; Gastrointestinal Transit; Hydrogen-Ion Concentration; Hydrolysis; In Vitro Techniques; Inflammatory Bowel Diseases; Male; Naproxen; Prodrugs; Rats; Sulindac	2008
Ionic liquid-based dynamic liquid-phase microextraction: application to the determination of anti-inflammatory drugs in urine samples. Journal of chromatography. A, 2008, Aug-15, Volume: 1202, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical Fractionation; Flurbiprofen; Humans; Hydrogen-Ion Concentration; Indomethacin; Ionic Liquids; Ketoprofen; Molecular Structure; Naproxen; Phenylbutyrates; Reproducibility of Results; Tolmetin	2008
Nanocomposites of 2-arylpropionic acid drugs based on Mg-Al layered double hydroxide for dissolution enhancement. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2008, Nov-15, Volume: 35, Issue:4 Topics: Aluminum Hydroxide; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Differential Thermal Analysis; Excipients; Flurbiprofen; L-Lactate Dehydrogenase; Magnesium Hydroxide; Nanoparticles; Naproxen; Solubility; Spectrophotometry, Infrared; X-Ray Diffraction	2008
Enantiomeric separation of acidic compounds by nano-liquid chromatography with methylated-beta-cyclodextrin as a mobile phase additive. Journal of separation science, 2009, Volume: 32, Issue:10 Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzoxazoles; beta-Cyclodextrins; Carbazoles; Chromatography, Liquid; Flurbiprofen; Hydrogen-Ion Concentration; Indoprofen; Ketoprofen; Methylation; Molecular Structure; Nanotechnology; Naproxen; Propionates; Stereoisomerism; Suprofen; Time Factors	2009
Differences in the interaction between aryl propionic acid derivatives and poly(vinylpyrrolidone) K30: A multi-methodological approach. Journal of pharmaceutical sciences, 2009, Volume: 98, Issue:11 Topics: Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Carbon Isotopes; Crystallization; Drug Stability; Flurbiprofen; Hot Temperature; Humidity; Hydrogen Bonding; Ibuprofen; Ketoprofen; Magnetic Resonance Spectroscopy; Molecular Structure; Molecular Weight; Naproxen; Phase Transition; Phenylbutyrates; Polymers; Povidone; Static Electricity; X-Ray Diffraction	2009
Simultaneous dissolution of naproxen and flurbiprofen from a novel ternary gamma-cyclodextrin complex. Chemical & pharmaceutical bulletin, 2010, Volume: 58, Issue:5 Topics: Chemistry, Pharmaceutical; Flurbiprofen; gamma-Cyclodextrins; Molecular Structure; Naproxen; Solubility; Water; X-Ray Diffraction	2010
Structural evaluation of crystalline ternary γ-cyclodextrin complex. Journal of pharmaceutical sciences, 2011, Volume: 100, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Chemical Precipitation; Excipients; Flurbiprofen; gamma-Cyclodextrins; Ketoprofen; Magnetic Resonance Spectroscopy; Molecular Conformation; Naproxen; Pharmaceutic Aids; Powder Diffraction; Salicylic Acid; Spectroscopy, Fourier Transform Infrared; Water	2011
Stereoselective inhibitory effect of flurbiprofen, ibuprofen and naproxen on human organic anion transporters hOAT1 and hOAT3. Biopharmaceutics & drug disposition, 2011, Volume: 32, Issue:9 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Humans; Ibuprofen; Inhibitory Concentration 50; Naproxen; Oocytes; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Stereoisomerism; Xenopus laevis	2011
Determination of non-steroidal anti-inflammatory drugs in urine by the combination of stir membrane liquid-liquid-liquid microextraction and liquid chromatography. Analytical and bioanalytical chemistry, 2012, Volume: 403, Issue:9 Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Liquid; Flurbiprofen; Humans; Indomethacin; Ketoprofen; Limit of Detection; Liquid Phase Microextraction; Naproxen	2012
Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3. PloS one, 2012, Volume: 7, Issue:8 Topics: 3-Hydroxysteroid Dehydrogenases; Aldo-Keto Reductase Family 1 Member C3; Anti-Inflammatory Agents, Non-Steroidal; Flufenamic Acid; Flurbiprofen; Hydroxyprostaglandin Dehydrogenases; Ibuprofen; Indomethacin; Meclofenamic Acid; Mefenamic Acid; Naproxen; Sulindac; Tolmetin	2012
Sensing chiral drugs by using CdSe/ZnS nanoparticles capped with N-acetyl-L-cysteine methyl ester. Chemistry (Weinheim an der Bergstrasse, Germany), 2013, Aug-12, Volume: 19, Issue:33 Topics: Acetylcysteine; Cadmium Compounds; Circular Dichroism; Esters; Flurbiprofen; Ibuprofen; Ketoprofen; Naproxen; Pharmaceutical Preparations; Quantum Dots; Selenium Compounds; Spectrometry, Fluorescence; Stereoisomerism; Sulfides; Zinc Compounds	2013
Pre-existent asymmetry in the human cyclooxygenase-2 sequence homodimer. The Journal of biological chemistry, 2013, Oct-04, Volume: 288, Issue:40 Topics: Acetylation; Amino Acid Sequence; Amino Acid Substitution; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Celecoxib; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Flurbiprofen; Guanidine; Heme; Humans; Indomethacin; Kinetics; Models, Biological; Mutant Proteins; Mutation; Naproxen; Oxygen; Palmitic Acid; Peroxidase; Protein Multimerization; Pyrazoles; Substrate Specificity; Sulfonamides	2013
Inhibition of fatty acid amide hydrolase and cyclooxygenase by the N-(3-methylpyridin-2-yl)amide derivatives of flurbiprofen and naproxen. European journal of pharmacology, 2013, Nov-15, Volume: 720, Issue:1-3 Topics: Amides; Amidohydrolases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cell Line, Tumor; Cyclooxygenase Inhibitors; Flurbiprofen; Male; Naproxen; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1	2013
Determination of thermodynamic values of acidic dissociation constants and complexation constants of profens and their utilization for optimization of separation conditions by Simul 5 Complex. Journal of chromatography. A, 2014, Oct-17, Volume: 1364 Topics: Anti-Inflammatory Agents, Non-Steroidal; beta-Cyclodextrins; Computer Simulation; Electrophoresis, Capillary; Flurbiprofen; Hydrogen-Ion Concentration; Ibuprofen; Ketoprofen; Magnetic Resonance Spectroscopy; Naproxen; Osmolar Concentration; Software; Thermodynamics; Viscosity	2014
Marginally designed new profen analogues have the potential to inhibit cyclooxygenase enzymes. Archiv der Pharmazie, 2015, Volume: 348, Issue:1 Topics: Arachidonate 5-Lipoxygenase; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Design; Flurbiprofen; Ibuprofen; Lipoxygenase Inhibitors; Molecular Structure; Naproxen; Propionates; Structure-Activity Relationship	2015
[[Chiral separation of five arylpropionic acid drugs and determination of their enantiomers in pharmaceutical preparations by reversed-phase high performance liquid chromatography with cellulose-tris-(4-methylbenzoate) stationary phase]]. Se pu = Chinese journal of chromatography, 2014, Volume: 32, Issue:9 Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Benzopyrans; Cellulose; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Flurbiprofen; Ibuprofen; Naproxen; Phenylpropionates; Propionates; Stereoisomerism	2014
Self-assembly of amphiphilic anionic calix[4]arenes and encapsulation of poorly soluble naproxen and flurbiprofen. Organic & biomolecular chemistry, 2015, Jun-21, Volume: 13, Issue:23 Topics: Anions; Calixarenes; Dynamic Light Scattering; Flurbiprofen; Magnetic Resonance Spectroscopy; Micelles; Microscopy, Atomic Force; Molecular Structure; Naproxen; Solubility; Surface-Active Agents	2015
Cyclosporin A-sensitive cytotoxicity of flurbiprofen non-stereoselectively mediated by cytochrome P450 metabolism in three-dimensional cultured rat hepatocytes. The Journal of pharmacy and pharmacology, 2015, Volume: 67, Issue:10 Topics: Adenosine Triphosphate; Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Cytochrome P-450 Enzyme System; Flurbiprofen; Hepatocytes; Ibuprofen; L-Lactate Dehydrogenase; Male; Mitochondria; Naproxen; Phenylpropionates; Rats; Rats, Wistar; Stereoisomerism	2015
Novel NSAID-Derived Drugs for the Potential Treatment of Alzheimer's Disease. International journal of molecular sciences, 2016, Jun-30, Volume: 17, Issue:7 Topics: Alzheimer Disease; Amyloid beta-Peptides; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cell Line; Cell Survival; Cyclooxygenase 2; Drug Stability; Flurbiprofen; Gene Expression; Humans; Interleukin-1beta; Naproxen; Peptide Fragments; Reactive Oxygen Species; Tetradecanoylphorbol Acetate; Thioctic Acid; Tumor Necrosis Factor-alpha	2016
Enantioselective simultaneous analysis of selected pharmaceuticals in environmental samples by ultrahigh performance supercritical fluid based chromatography tandem mass spectrometry. Analytica chimica acta, 2016, Aug-31, Volume: 934 Topics: Aminorex; Carbazoles; Chloramphenicol; Chromatography, High Pressure Liquid; Chromatography, Supercritical Fluid; Flurbiprofen; Humans; Ibuprofen; Ifosfamide; Imidazoles; Indoprofen; Molecular Structure; Naproxen; Ofloxacin; Omeprazole; Praziquantel; Solid Phase Extraction; Stereoisomerism; Tandem Mass Spectrometry; Tetramisole; Water Pollutants, Chemical	2016
Effect of guest drug character encapsulated in the cavity and intermolecular spaces of γ-cyclodextrins on the dissolution property of ternary γ-cyclodextrin complex. International journal of pharmaceutics, 2017, Oct-15, Volume: 531, Issue:2 Topics: Chemistry, Pharmaceutical; Drug Carriers; Flurbiprofen; gamma-Cyclodextrins; Ketoprofen; Naproxen; Salicylamides; Solubility	2017
Photochemically Controlled Drug Dosing from a Polymeric Scaffold. Pharmaceutical research, 2017, Volume: 34, Issue:7 Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Carriers; Drug Liberation; Flurbiprofen; Humans; Naproxen; Photochemical Processes; Photolysis; Polymethacrylic Acids; Ultraviolet Rays	2017
The nature of hydrogen-bonding interactions in nonsteroidal anti-inflammatory drugs revealed by polarized IR spectroscopy. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2018, Jan-05, Volume: 188 Topics: Anti-Inflammatory Agents, Non-Steroidal; Crystallography, X-Ray; Deuterium; Flurbiprofen; Hydrogen Bonding; Ketoprofen; Naproxen; Spectrophotometry, Infrared; Vibration	2018
Levetiracetam+nonsteroidal anti-inflammatory drug binary systems: A contribution to the development of new solid dosage forms. International journal of pharmaceutics, 2017, Nov-25, Volume: 533, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Drug Combinations; Drug Liberation; Flurbiprofen; Ibuprofen; Ketoprofen; Levetiracetam; Naproxen; Piracetam; Stereoisomerism	2017
Correlation between glucuronidation and covalent adducts formation with proteins of nonsteroidal anti-inflammatory drugs. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2018, Jan-15, Volume: 112 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Flurbiprofen; Glucuronides; Ibuprofen; Ketoprofen; Male; Microsomes, Liver; Naproxen; Propionates; Protein Binding; Rats, Wistar	2018
Simultaneous enantiomeric analysis of non-steroidal anti-inflammatory drugs in environment by chiral LC-MS/MS: A pilot study in Beijing, China. Ecotoxicology and environmental safety, 2019, Jun-15, Volume: 174 Topics: Anti-Inflammatory Agents, Non-Steroidal; Beijing; Chromatography, High Pressure Liquid; Environmental Monitoring; Flurbiprofen; Ibuprofen; Naproxen; Pilot Projects; Rivers; Stereoisomerism; Tandem Mass Spectrometry; Water Pollutants, Chemical	2019
Formation of Drug-Participating Catanionic Aggregates for Extended Delivery of Non-Steroidal Anti-Inflammatory Drugs from Contact Lenses. Biomolecules, 2019, 10-10, Volume: 9, Issue:10 Topics: Anti-Inflammatory Agents, Non-Steroidal; Cations; Contact Lenses; Diclofenac; Diffusion; Drug Delivery Systems; Drug Liberation; Fatty Alcohols; Flurbiprofen; Hydrophobic and Hydrophilic Interactions; Kinetics; Naproxen; Quaternary Ammonium Compounds; Surface-Active Agents; Viscosity	2019
Efficient Palladium-Catalyzed Synthesis of 2-Aryl Propionic Acids. Molecules (Basel, Switzerland), 2020, Jul-28, Volume: 25, Issue:15 Topics: Catalysis; Flurbiprofen; Naproxen; Palladium	2020
Cisplatin-cyclooxygenase inhibitor conjugates, free and immobilised in mesoporous silica SBA-15, prove highly potent against triple-negative MDA-MB-468 breast cancer cell line. Dalton transactions (Cambridge, England : 2003), 2022, Jan-17, Volume: 51, Issue:3 Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cisplatin; Cyclooxygenase Inhibitors; Female; Flurbiprofen; Humans; Ibuprofen; Molecular Structure; Naproxen; Platinum; Silicon Dioxide	2022
Chiral Inversion of 2-Arylpropionic Acid Enantiomers under Anaerobic Conditions. Environmental science & technology, 2022, 06-21, Volume: 56, Issue:12 Topics: Anaerobiosis; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Naproxen; Stereoisomerism	2022
Masking the Taste of Fixed-Dose Combination Drugs: Particular NSAIDs Can Efficiently Mask the Bitterness of Famotidine. Chemical & pharmaceutical bulletin, 2023, Volume: 71, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Famotidine; Flurbiprofen; Ibuprofen; Naproxen; Taste	2023
Preparation and chromatographic performance of chiral peptide-based stationary phases for enantiomeric separation. Chirality, 2023, Volume: 35, Issue:9 Topics: Chromatography, High Pressure Liquid; Flurbiprofen; Naproxen; Reproducibility of Results; Stereoisomerism	2023