flurbiprofen and methotrexate

flurbiprofen has been researched along with methotrexate in 20 studies

Research

Studies (20)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (25.00)	18.7374
1990's	4 (20.00)	18.2507
2000's	3 (15.00)	29.6817
2010's	8 (40.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Andrews, PR; Craik, DJ; Martin, JL	1
Topliss, JG; Yoshida, F	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Bennett, A; Berstock, DA; Houghton, J	2
Frenia, ML; Long, KS	1
Coates, J; Friedman, H; Jamali, F; Russell, AS; Skeith, KJ	1
Goldberg, RL; Rubin, AS	1
Bennett, A; Berstock, DA; Carroll, MA	1
Bradley, JD; Brater, DC; Greene, PK; Tracy, TS; Worster, T	1
Fournier, DJ; Statkevich, P; Sweeney, KR	1

Reviews

2 review(s) available for flurbiprofen and methotrexate

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Methotrexate and nonsteroidal antiinflammatory drug interactions. The Annals of pharmacotherapy, 1992, Volume: 26, Issue:2 Topics: Adult; Aged; Blood Component Transfusion; Drug Interactions; Female; Flurbiprofen; Folic Acid; Hospitalization; Humans; Methotrexate; Ranitidine; Sucralfate; Vitamin K	1992

Trials

1 trial(s) available for flurbiprofen and methotrexate

Article	Year
Methotrexate disposition following concomitant administration of ketoprofen, piroxicam and flurbiprofen in patients with rheumatoid arthritis. British journal of clinical pharmacology, 1994, Volume: 37, Issue:5 Topics: Administration, Oral; Adult; Aged; Arthritis, Rheumatoid; Drug Interactions; Drug Therapy, Combination; Female; Fluorescence Polarization Immunoassay; Flurbiprofen; Humans; Ketoprofen; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Piroxicam	1994

Article

Year

Methotrexate disposition following concomitant administration of ketoprofen, piroxicam and flurbiprofen in patients with rheumatoid arthritis.

British journal of clinical pharmacology, 1994, Volume: 37, Issue:5

Topics: Administration, Oral; Adult; Aged; Arthritis, Rheumatoid; Drug Interactions; Drug Therapy, Combination; Female; Fluorescence Polarization Immunoassay; Flurbiprofen; Humans; Ketoprofen; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Piroxicam

1994

Other Studies

17 other study(ies) available for flurbiprofen and methotrexate

Article	Year
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Improved anticancer effect by combining cytotoxic drugs with an inhibitor of prostaglandin synthesis. Cancer treatment reviews, 1979, Volume: 6 Suppl Topics: Animals; Cyclooxygenase Inhibitors; Drug Synergism; Drug Therapy, Combination; Female; Flurbiprofen; Mammary Neoplasms, Experimental; Melphalan; Methotrexate; Mice; Propionates	1979
Lack of significant interaction between low dose methotrexate and ibuprofen or flurbiprofen in patients with arthritis. The Journal of rheumatology, 1990, Volume: 17, Issue:8 Topics: Administration, Oral; Aged; Arthritis, Rheumatoid; Drug Interactions; Female; Flurbiprofen; Humans; Ibuprofen; Injections, Intramuscular; Male; Methotrexate; Middle Aged	1990
Serum hyaluronate as a marker for disease severity in the Lactobacillus casei model of arthritis in the rat. The Journal of rheumatology, 1989, Volume: 16, Issue:1 Topics: Animals; Arthritis; Arthritis, Experimental; Biomarkers; Enzyme-Linked Immunosorbent Assay; Female; Flurbiprofen; Hyaluronic Acid; Lacticaseibacillus casei; Methotrexate; Rats; Rats, Inbred Lew	1989
Increased survival of cancer-bearing mice treated with inhibitors of prostaglandin synthesis alone or with chemotherapy. British journal of cancer, 1982, Volume: 45, Issue:5 Topics: Adenocarcinoma; Animals; Biological Availability; Body Weight; Drug Therapy, Combination; Female; Flurbiprofen; Indomethacin; Male; Mammary Neoplasms, Experimental; Melphalan; Methotrexate; Mice; Neoplasm Recurrence, Local; Propionates; Prostaglandin Antagonists	1982
Improved anticancer effect by combining cytotoxic drugs with an inhibitor of prostaglandin synthesis. Advances in prostaglandin and thromboxane research, 1980, Volume: 6 Topics: Adenocarcinoma; Animals; Drug Evaluation, Preclinical; Female; Flurbiprofen; Mammary Neoplasms, Experimental; Melphalan; Methotrexate; Mice; Neoplasm Recurrence, Local; Propionates; Prostaglandin Antagonists	1980
Characterization of methotrexate elimination and interaction with indomethacin and flurbiprofen in the isolated perfused rat kidney. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:3 Topics: Animals; Drug Interactions; Flurbiprofen; In Vitro Techniques; Indomethacin; Kidney; Male; Methotrexate; Perfusion; Proteins; Rats; Rats, Sprague-Dawley	1993