flurbiprofen has been researched along with chf 5074 in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (17.39) | 29.6817 |
| 2010's | 19 (82.61) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bigogno, C; Biscaioli, M; Bolzoni, PT; Caruso, P; Catinella, S; Cenacchi, V; Del Giudice, E; Dondio, G; Facchinetti, F; Fontanella, L; Imbimbo, BP; Marchetti, S; Misiano, P; Moretto, N; Parini, C; Peretto, I; Puccini, P; Radaelli, S; Raveglia, LF; Riccardi, B; Rizzi, A; Rondelli, I; Villetti, G; Zandi, M | 1 |
| Berthelot, DJ; Gijsen, HJ; Oehlrich, D | 1 |
| Abdul-Hay, S; Qin, Z; Schiefer, IT; Thatcher, GR; Vanni, M; Wang, H | 1 |
| Cenacchi, V; Del Giudice, E; Facchinetti, F; Grassi, F; Imbimbo, BP; Leon, A; Moretto, N; Ottonello, S; Puccini, P; Riccardi, B; Villetti, G; Volta, R | 1 |
| Baroc, MF; Colavito, D; D'Arrigo, A; Dalle Carbonare, M; De Strooper, B; Del Giudice, E; Facchinetti, F; Imbimbo, BP; Leon, A; Pietrini, V; Serneels, L; Villetti, G; Volta, R | 1 |
| Cenacchi, V; Facchinetti, F; Hutter-Paier, B; Imbimbo, BP; Lanzillotta, A; Pizzi, M; Villetti, G; Volta, R; Windisch, M | 1 |
| Calzà, L; D'Arrigo, A; Del Giudice, E; Giardino, L; Giuliani, A; Gusciglio, M; Imbimbo, BP; Leon, A; Pietrini, V; Sivilia, S; Villetti, G | 1 |
| Baltrons, MA; Carriba, P; Galea, E; García, A; Lichtenstein, MP; Peterson, JR; Wojciak-Stothard, B | 1 |
| Baiguera, C; Benarese, M; Branca, C; Hutter-Paier, B; Imbimbo, BP; Lanzillotta, A; Pizzi, M; Sarnico, I; Spano, P; Windisch, M | 1 |
| Balducci, C; Calzà, L; Forloni, G; Giardino, L; Giuliani, A; Imbimbo, BP; Lanzillotta, A; Lorenzini, L; Mare, L; Mehdawy, B; Nisticò, G; Nisticò, R; Ottonello, S; Pizzi, M; Sarnico, I; Sivilia, S; Usiello, A; Villetti, G; Viscomi, AR | 1 |
| Antonelli, T; Baldassarro, VA; Beggiato, S; Calzà, L; Ferraro, L; Giardino, L; Giuliani, A; Imbimbo, BP; Mangano, C | 1 |
| Baldassarro, VA; Baroc, MF; Calzà, L; Fernandez, M; Ferraro, L; Giardino, L; Giuliani, A; Gusciglio, M; Imbimbo, BP; Lorenzini, L; Mangano, C; Ottonello, S; Pietrini, V; Sivilia, S; Villetti, G; Viscomi, AR | 1 |
| Alessandri, M; Baldassarro, VA; Calzà, L; Fernandez, M; Giardino, L; Giuliani, A; Gusciglio, M; Lorenzini, L; Mangano, C; Sivilia, S; Torricella, R | 1 |
| Bottini, G; Calza, L; Casula, D; Cicirello, H; Fernandez, M; Fiorentini, F; Franceschi, M; Frigerio, E; Giardino, L; Imbimbo, BP; Norris, D; Nunez, M; Ross, J; Scarpini, E; Sharma, S; Sivilia, S; Winston, J | 1 |
| Antonelli, T; Beggiato, S; Calzà, L; Ferraro, L; Giardino, L; Giuliani, A; Imbimbo, BP; Lorenzini, L; Sivilia, S | 1 |
| Barbato, G; Benarese, M; Blandini, F; Feligioni, M; Graziani, M; Imbimbo, BP; Lanzillotta, A; Mango, D; Mercuri, NB; Nicoletti, F; Nisticò, R; Panico, MB; Piccirilli, S; Pieraccini, S; Pizzi, M; Porrini, V; Schepisi, C; Sironi, M | 1 |
| Benarese, M; Branca, C; Calzà, L; Imbimbo, BP; Lanzillotta, A; Lorenzini, L; Ottonello, S; Pizzi, M; Porrini, V; Ruotolo, R; Sarnico, I; Viscomi, AR | 1 |
| Amoroso, S; Bernardini, R; Cantarella, G; Di Benedetto, G; Parenti, C; Ronsisvalle, N | 1 |
| Benarese, M; Branca, C; Calzà, L; Flaibani, R; Imbimbo, BP; Lanzillotta, A; Lorenzini, L; Parrella, E; Pizzi, M; Porrini, V; Spano, PF | 1 |
| Imbimbo, BP; Jin, S; Li, Z; Mu, Y; Qiang, L; Shen, J; Sugano, A; Takaoka, Y; Yamamura, K | 1 |
| Bellucci, A; Benarese, M; Branca, C; Faggi, L; Imbimbo, BP; Lanzillotta, A; Mota, M; Parrella, E; Pizzi, M; Porrini, V; Sarnico, I; Spano, P | 1 |
| Guan, Y; Imbimbo, BP; Jin, S; Li, X; Li, Z; Liu, L; Mu, Y; Qiang, L; Sakaeda, T; Sugano, A; Takaoka, Y; Yamamura, KI | 1 |
| Chang, CH; Chang, CP; Chio, CC; Hsu, CC; Lin, HJ; Lin, MT; Lin, TW; Tian, YF | 1 |
2 review(s) available for flurbiprofen and chf 5074
| Article | Year |
|---|---|
γ-Secretase modulators as potential disease modifying anti-Alzheimer's drugs.
Topics: Alzheimer Disease; Amides; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cinnamates; Clinical Trials as Topic; Ginsenosides; Humans; Isoenzymes; Stereoisomerism | 2011 |
From the multifactorial nature of Alzheimer`s disease to multitarget therapy: the contribution of the translational approach.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Anti-Inflammatory Agents; Cyclopropanes; Drug Design; Enzyme Inhibitors; Flurbiprofen; Humans; Inflammation; Mice; Mice, Transgenic; Nootropic Agents; Synapses; Synaptic Transmission; Translational Research, Biomedical | 2013 |
2 trial(s) available for flurbiprofen and chf 5074
| Article | Year |
|---|---|
CHF5074 reduces biomarkers of neuroinflammation in patients with mild cognitive impairment: a 12-week, double-blind, placebo-controlled study.
Topics: Adult; Aged; Amyloid Precursor Protein Secretases; Biomarkers; Cognitive Dysfunction; Cohort Studies; Cyclopropanes; Dose-Response Relationship, Drug; Double-Blind Method; Female; Flurbiprofen; Humans; Inflammation; Male; Middle Aged | 2013 |
CSP-1103 (CHF5074) stabilizes human transthyretin in healthy human subjects.
Topics: Amyloidosis; Cyclopropanes; Flurbiprofen; Genetic Diseases, Inborn; Humans; Prealbumin; Thyroxine | 2017 |
19 other study(ies) available for flurbiprofen and chf 5074
| Article | Year |
|---|---|
Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood-Brain Barrier; Caco-2 Cells; Cell Line, Tumor; Cell Membrane Permeability; Cyclooxygenase Inhibitors; Flurbiprofen; Glioma; Humans; Immunoassay; In Vitro Techniques; Injections, Intravenous; Mice; Mice, Transgenic; Peptide Fragments; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Stereoisomerism; Structure-Activity Relationship | 2005 |
Inhibition of amyloidogenesis by nonsteroidal anti-inflammatory drugs and their hybrid nitrates.
Topics: Amyloid beta-Peptides; Amyloidosis; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Humans; Mice; Neurons; Nitrates; Small Molecule Libraries | 2011 |
In vitro and in vivo profiling of CHF5022 and CHF5074 Two beta-amyloid1-42 lowering agents.
Topics: Administration, Oral; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cell Line, Tumor; Cell Survival; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Cyclopropanes; Dose-Response Relationship, Drug; Down-Regulation; Flurbiprofen; Gene Expression; Humans; Insecta; Membrane Proteins; Mice; Mice, Transgenic; Mutation; Nootropic Agents; Peptide Fragments; Time Factors; Transfection | 2007 |
1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cell Line; Cyclopropanes; Disease Models, Animal; Female; Flurbiprofen; Humans; Male; Mice; Mice, Transgenic; Molecular Structure; Peptide Fragments; Tissue Distribution | 2007 |
CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Brain; Cyclopropanes; Flurbiprofen; Humans; Ibuprofen; Learning Disabilities; Memory; Mice; Mice, Transgenic; Microglia; Mutation; Peptide Fragments; Plaque, Amyloid | 2009 |
CHF5074, a novel gamma-secretase modulator, restores hippocampal neurogenesis potential and reverses contextual memory deficit in a transgenic mouse model of Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Cerebral Cortex; Conditioning, Classical; Cyclopropanes; Disease Models, Animal; Flurbiprofen; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Humans; Memory Disorders; Mice; Mice, Transgenic; Microglia; Mutation; Neurogenesis; Presenilin-1; Statistics as Topic; Synaptophysin | 2010 |
Secretase-independent and RhoGTPase/PAK/ERK-dependent regulation of cytoskeleton dynamics in astrocytes by NSAIDs and derivatives.
Topics: Amyloid Precursor Protein Secretases; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Blotting, Western; Cells, Cultured; Cerebellum; Cerebral Cortex; Cyclooxygenase 2; Cyclopropanes; Cytoskeleton; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Flurbiprofen; Ibuprofen; Immunohistochemistry; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Signal Transduction | 2010 |
The γ-secretase modulator CHF5074 reduces the accumulation of native hyperphosphorylated tau in a transgenic mouse model of Alzheimer's disease.
Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Cells, Cultured; Cyclooxygenase Inhibitors; Cyclopropanes; Diet; Disease Models, Animal; Flurbiprofen; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Ibuprofen; Mice; Mice, Transgenic; Neurons; Peptide Fragments; Phosphorylation; Signal Transduction; tau Proteins | 2011 |
The γ-secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice.
Topics: Amyloid Precursor Protein Secretases; Animals; Cricetinae; Cyclopropanes; Female; Flurbiprofen; Hippocampus; Humans; Memory; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuronal Plasticity; Plaque, Amyloid; Synapses | 2011 |
CHF5074 restores visual memory ability and pre-synaptic cortical acetylcholine release in pre-plaque Tg2576 mice.
Topics: Acetylcholine; Alzheimer Disease; Animals; Cerebral Cortex; Cyclopropanes; Disease Models, Animal; Female; Flurbiprofen; Humans; Memory; Mice; Mice, Transgenic; Neuroprotective Agents; Synaptosomes | 2013 |
Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Antipsychotic Agents; Brain; Cyclin A; Cyclopropanes; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Flurbiprofen; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Mutation; Peptide Fragments; Phosphopyruvate Hydratase; Plaque, Amyloid; Recognition, Psychology; Silver Staining | 2013 |
CHF5074 and LY450139 sub-acute treatments differently affect cortical extracellular glutamate levels in pre-plaque Tg2576 mice.
Topics: Alanine; Alzheimer Disease; Animals; Azepines; Cyclopropanes; Disease Models, Animal; Extracellular Space; Female; Flurbiprofen; Glutamic Acid; Humans; Mice; Mice, Transgenic; Microdialysis; Neuroprotective Agents; Prefrontal Cortex; Synaptic Transmission | 2014 |
Electrophysiological and metabolic effects of CHF5074 in the hippocampus: protection against in vitro ischemia.
Topics: Acetates; Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartic Acid; Cells, Cultured; Cyclopropanes; Electrophysiological Phenomena; Flurbiprofen; Hippocampus; In Vitro Techniques; Ischemia; Lactic Acid; Male; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Rats, Wistar | 2014 |
Pharmacological targeting of the β-amyloid precursor protein intracellular domain.
Topics: Acetylation; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Cell Line, Tumor; Cyclopropanes; Flurbiprofen; Histones; Humans; Kangai-1 Protein; Peptide Fragments; Protein Structure, Tertiary; Transcription, Genetic | 2014 |
CHF5074 protects SH-SY5Y human neuronal-like cells from amyloidbeta 25-35 and tumor necrosis factor related apoptosis inducing ligand toxicity in vitro.
Topics: Amyloid beta-Peptides; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; Cyclopropanes; Dose-Response Relationship, Drug; Flurbiprofen; Humans; Neuroprotective Agents; Nitric Oxide Synthase Type II; Peptide Fragments; Phosphotransferases; tau Proteins; Time Factors; TNF-Related Apoptosis-Inducing Ligand | 2014 |
CHF5074 (CSP-1103) induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Brain; Case-Control Studies; Cells, Cultured; Cyclopropanes; Cytokines; Disease Models, Animal; Female; Flurbiprofen; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neuroglia; Nitric Oxide Synthase Type II; Time Factors | 2015 |
CHF5074 (CSP-1103) stabilizes human transthyretin in mice humanized at the transthyretin and retinol-binding protein loci.
Topics: Animals; Binding Sites; Cyclopropanes; Flurbiprofen; Humans; Liver; Mice; Models, Molecular; Plasma; Prealbumin; Protein Stability; Retinol-Binding Proteins, Plasma; Valine | 2015 |
Neuroprotective and Anti-Apoptotic Effects of CSP-1103 in Primary Cortical Neurons Exposed to Oxygen and Glucose Deprivation.
Topics: Animals; Apoptosis; Caspase 3; Cell Nucleus; Cerebral Cortex; Cyclopropanes; Cytochromes c; Enzyme Activation; Flurbiprofen; Glucose; Glycogen Synthase Kinase 3 beta; Ibuprofen; Mice, Inbred C57BL; Necrosis; Neurons; Neuroprotective Agents; Oxygen; p38 Mitogen-Activated Protein Kinases; Transcription Factor RelA | 2017 |
Gamma-Secretase Inhibitors Attenuate Neurotrauma and Neurogenic Acute Lung Injury in Rats by Rescuing the Accumulation of Hypertrophic Microglia.
Topics: Acute Lung Injury; Alanine; Amyloid Precursor Protein Secretases; Animals; Azepines; Blood-Brain Barrier; Brain; Brain Injuries, Traumatic; Bronchoalveolar Lavage Fluid; Cerebral Cortex; Cyclopropanes; Cytokines; Disease Models, Animal; Flurbiprofen; Lung; Male; Microglia; Neuroprotective Agents; Neutrophils; Rats; Rats, Sprague-Dawley | 2017 |