Compounds > flurbiprofen

flurbiprofen and 4'-hydroxyflurbiprofen

flurbiprofen has been researched along with 4'-hydroxyflurbiprofen in 13 studies

Research

Studies (13)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (23.08)	18.2507
2000's	5 (38.46)	29.6817
2010's	5 (38.46)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bigogno, C; Biscaioli, M; Bolzoni, PT; Caruso, P; Catinella, S; Cenacchi, V; Del Giudice, E; Dondio, G; Facchinetti, F; Fontanella, L; Imbimbo, BP; Marchetti, S; Misiano, P; Moretto, N; Parini, C; Peretto, I; Puccini, P; Radaelli, S; Raveglia, LF; Riccardi, B; Rizzi, A; Rondelli, I; Villetti, G; Zandi, M	1
Cefali, EA; Cox, S; Poynor, WJ; Sica, D	1
Adams, WJ; Cox, SR; Small, RE	1
Gonzalez, FJ; Korzekwa, KR; Rosenbluth, BW; Tracy, TS; Wrighton, SA	1
Frye, RF; Hutzler, JM; Tracy, TS	1
Branch, RA; Frye, RF; Huang, SM; Hutzler, JM; Korzekwa, KR; Tracy, TS	1
Blaisdell, JA; Frye, RF; Goldstein, JA; Hinderliter, AL; Lee, CR; Pieper, JA	1
Locuson, CW; Low, M; Subramanian, M; Tracy, TS	1
Keseru, GM; Kiss, R; Tarcsay, A	1
Amadio, J; Gordon, K; Murphy, CD	1
Brouwer, KL; Dooley, MA; Falk, RJ; Frye, RF; Joy, MS; La, MK; Nolin, TD; Roberts, BV; Wang, J	1
Byeon, JY; Choi, CI; Jang, CG; Kim, SH; Kim, YH; Lee, HI; Lee, JE; Lee, SY; Lee, YJ; Park, SY	1
Bae, JW; Byeon, JY; Choi, CI; Jang, CG; Kim, SH; Kim, YH; Lee, J; Lee, SY; Lee, YJ; Sohn, UD	1

Trials

4 trial(s) available for flurbiprofen and 4'-hydroxyflurbiprofen

Article	Year
Pharmacokinetic comparison of flurbiprofen in end-stage renal disease subjects and subjects with normal renal function. Journal of clinical pharmacology, 1991, Volume: 31, Issue:9 Topics: Adult; Female; Flurbiprofen; Hemodialysis Solutions; Humans; Isomerism; Kidney Failure, Chronic; Male; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory	1991
Influence of H2 receptor antagonists on the disposition of flurbiprofen enantiomers. Journal of clinical pharmacology, 1990, Volume: 30, Issue:7 Topics: Adult; Cimetidine; Drug Administration Schedule; Drug Interactions; Flurbiprofen; Humans; Isomerism; Random Allocation; Ranitidine; Time Factors	1990
Differences in flurbiprofen pharmacokinetics between CYP2C91/1, 1/2, and 1/3 genotypes. European journal of clinical pharmacology, 2003, Volume: 58, Issue:12 Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Female; Flurbiprofen; Genotype; Humans; Male	2003
In vivo alterations in drug metabolism and transport pathways in patients with chronic kidney diseases. Pharmacotherapy, 2014, Volume: 34, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Biological Transport; Breath Tests; Case-Control Studies; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Female; Flurbiprofen; Glomerulonephritis; Humans; Male; Middle Aged; Prospective Studies; Renal Insufficiency, Chronic; Terfenadine; Young Adult	2014

Other Studies

9 other study(ies) available for flurbiprofen and 4'-hydroxyflurbiprofen

Article	Year
Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. Journal of medicinal chemistry, 2005, Sep-08, Volume: 48, Issue:18 Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood-Brain Barrier; Caco-2 Cells; Cell Line, Tumor; Cell Membrane Permeability; Cyclooxygenase Inhibitors; Flurbiprofen; Glioma; Humans; Immunoassay; In Vitro Techniques; Injections, Intravenous; Mice; Mice, Transgenic; Peptide Fragments; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Stereoisomerism; Structure-Activity Relationship	2005
Role of cytochrome P450 2C9 and an allelic variant in the 4'-hydroxylation of (R)- and (S)-flurbiprofen. Biochemical pharmacology, 1995, May-11, Volume: 49, Issue:9 Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Flurbiprofen; Humans; Hydroxylation; Microsomes, Liver; Stereoisomerism; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases	1995
Sensitive and specific high-performance liquid chromatographic assay for 4'-hydroxyflurbiprofen and flurbiprofen in human urine and plasma. Journal of chromatography. B, Biomedical sciences and applications, 2000, Nov-10, Volume: 749, Issue:1 Topics: Aryl Hydrocarbon Hydroxylases; Calibration; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Flurbiprofen; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases	2000
Minimal in vivo activation of CYP2C9-mediated flurbiprofen metabolism by dapsone. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2001, Volume: 14, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Dapsone; Enzyme Activation; Enzyme Activators; Flurbiprofen; Indicators and Reagents; Kinetics; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases	2001
CYP2D6-CYP2C9 protein-protein interactions and isoform-selective effects on substrate binding and catalysis. Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:8 Topics: Aryl Hydrocarbon Hydroxylases; Binding Sites; Biocatalysis; Catalytic Domain; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Dealkylation; Dextromethorphan; Dextrorphan; Flurbiprofen; Humans; Hydroxylation; Kinetics; Models, Biological; NADPH-Ferrihemoprotein Reductase; Spectrum Analysis; Substrate Specificity	2009
Site of metabolism prediction on cytochrome P450 2C9: a knowledge-based docking approach. Journal of computer-aided molecular design, 2010, Volume: 24, Issue:5 Topics: Aryl Hydrocarbon Hydroxylases; Camphor; Catalytic Domain; Computer Simulation; Cytochrome P-450 CYP2C9; Flurbiprofen; Humans; Knowledge Bases; Models, Molecular; Protein Conformation; Substrate Specificity	2010
Biotransformation of flurbiprofen by Cunninghamella species. Applied and environmental microbiology, 2010, Volume: 76, Issue:18 Topics: Anti-Inflammatory Agents, Non-Steroidal; Biotransformation; Chromatography, High Pressure Liquid; Cunninghamella; Flurbiprofen; Gas Chromatography-Mass Spectrometry; Magnetic Resonance Spectroscopy; Molecular Structure	2010
Simultaneous determination of flurbiprofen and its hydroxy metabolite in human plasma by liquid chromatography-tandem mass spectrometry for clinical application. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2014, Nov-15, Volume: 971 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Chromatography, High Pressure Liquid; Flurbiprofen; Humans; Male; Quality Control; Reproducibility of Results; Republic of Korea; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry	2014
Effects of CYP2C91/3 genotype on the pharmacokinetics of flurbiprofen in Korean subjects. Archives of pharmacal research, 2015, Volume: 38, Issue:6 Topics: Adult; Alleles; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Asian People; Biotransformation; Cytochrome P-450 CYP2C9; Female; Flurbiprofen; Genotype; Humans; Isoenzymes; Kinetics; Male; Young Adult	2015