fluphenazine has been researched along with clozapine in 92 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 24 (26.09) | 18.7374 |
1990's | 32 (34.78) | 18.2507 |
2000's | 24 (26.09) | 29.6817 |
2010's | 10 (10.87) | 24.3611 |
2020's | 2 (2.17) | 2.80 |
Authors | Studies |
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Ellefson, CR; Kehr, JR; Miller, A; Woo, CM | 1 |
Krapcho, J; Michel, IM; Turk, CF; Weinryb, I | 1 |
George, SR; Guan, HC; Laurier, LG; Ng, G; Niznik, HB; O'Dowd, BF; Seeman, P; Sunahara, RK; Torchia, J; Van Tol, HH | 1 |
Butler, DE; Coughenour, LL; DeWald, HA; Downs, DA; Heffner, TG; Lustgarten, D; Pugsley, TA; Wise, LD | 1 |
Choudhary, MS; Craigo, SC; Meltzer, HY; Monsma, FJ; Roth, BL; Shen, Y; Sibley, DR; Uluer, A | 1 |
Strassburg, CP; Tukey, RH | 1 |
Ernsberger, P; Hufeisen, SJ; Jayathilake, K; Kroeze, WK; Meltzer, HY; Popadak, BA; Renock, SM; Roth, BL; Steinberg, S | 1 |
Andaluz, B; Buschmann, H; Codony, X; Cubí, R; Díaz, JL; Dordal, A; Guitart, X; Hernández, E; Hernández, S; Holenz, J; Mas, J; Mercè, R; Monroy, X; Pérez, R; Romero, G; Sánchez, E; Sanfeliu, O; Torrens, A | 1 |
Herrick-Davis, K; Purohit, A; Smith, C; Teitler, M | 1 |
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
Kottke, T; Ligneau, X; Stark, H; von Coburg, Y; Weizel, L | 1 |
García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Modestin, J; Petrin, A | 1 |
Gründig, E; Weiss, J | 1 |
Bowers, MB; Rozitis, A | 2 |
Clement-Cormier, YC; Robison, GA | 1 |
Munday, KA; Poat, JA; Sumners, C; Woodruff, GN | 1 |
Kudrin, VS; Mineyeva, MF; Rayevsky, KS | 1 |
Bloss, JL; Singer, GH | 1 |
Costall, B; Naylor, RJ | 2 |
Ahn, HS; Demirjian, C; Makman, MH; Mishra, RK | 1 |
Gutierrez, R; Konicki, E; Litman, RE; Owen, RR; Pickar, D; Rapaport, MH | 1 |
Pickar, D | 1 |
Kirch, DG; McAllister, CG; Pickar, D; Rapaport, MH | 1 |
Ellison, G; See, RE | 1 |
Salama, AI; Saller, CF | 1 |
Cohen, BM; Lipinski, JF | 1 |
Choras, PT; Cole, JO; Fulwiler, CE; Pope, HG | 1 |
Auer, B; Barnas, C; Fleischhacker, W; Haring, C; Hinterhuber, H; Humpel, C; Saria, A | 1 |
Greenberg, D; Snyder, SH; Yamumura, HI | 1 |
Schechter, MD | 1 |
Aranovich, AG; Gamburg, AL; Kotel'kevich, IuN; Omorokov, BM; Rasniuk, VA | 1 |
Borison, RL; Diamond, BI | 1 |
Friedman, E; Gianutsos, G; Kuster, J | 1 |
Faustman, WO; Fowler, SC | 1 |
Arnt, J | 1 |
Hsiao, JK; Litman, RE; Owen, RR; Pickar, D; Su, TP | 1 |
Bechter, K | 1 |
Cawley, TA; Luthin, GR; Ruggieri, MR; Shickley, TJ | 1 |
Opler, LA; Yovell, Y | 1 |
Haier, RJ; Pickar, D; Zahn, TP | 1 |
Clem, T; Hommer, DW; Litman, RE; Pickar, D; Radant, A | 1 |
Chen, JF; Weiss, B | 1 |
Dorevitch, A; Durst, R; Fraenkel, Y | 1 |
Hong, WW; Hsiao, JK; Litman, RE; Pickar, D; Potter, WZ; Su, TP; Weissman, EM | 1 |
Benkelfat, C; Gutierrez-Esteinou, R; Hadd, K; Hsiao, J; Lawlor, BA; Murphy, DL; Owen, RR; Pickar, D | 1 |
Fiorella, D; Rabin, RA; Winter, JC | 1 |
Hong, WW; Litman, RE; Pickar, D; Potter, WZ; Su, TP | 1 |
Bauer, U; Gallhofer, B; Gruppe, H; Krieger, S; Lis, S | 1 |
Fukamauchi, F; Kito, S; Mataga, N; Miyoshi, R; Sakai, M; Semba, J | 1 |
Andreason, P; Cohen, RM; Litman, RE; Nordahl, TE; Pickar, D; Semple, WE | 1 |
Bunker, MT; Marken, PA; Ruehter, VL; Schneiderhan, ME | 1 |
Braghiroli, L; Cheng, CY; De Feo, G; Fiani, M; Mazzanti, G; Ponzianelli, A | 1 |
Baldessarini, RJ; Kula, NS; Neumeyer, JL; Tarazi, FI; Yeghiayan, SK | 1 |
Breier, A; Elman, I; Goldstein, DS | 1 |
Oreland, L; Prince, JA; Yassin, MS | 1 |
Baumgartner, R; Gönner, F; Merlo, MC; Schüpbach, D | 1 |
Buljat, G; Dodig, G; Jelovac, N; Marovic, A; Miklic, P; Mise, S; Perovic, D; Petek, M; Prkacin, I; Rucman, R; Seiwerth, S; Sikiric, P; Turkovic, B | 1 |
Cohen, RM; Nordahl, TE; Pickar, D; Semple, WE | 1 |
Braghiroli, L; Mazzanti, G; Ponzianelli, A | 1 |
Bradley, RJ; Dwyer, DS; Liu, Y | 1 |
Jakovljevic, M; Mihaljević-Peles, A; Mrsic, M; Sagud, M | 1 |
Miledi, R; Nguyen, QT; Yang, J | 1 |
Marder, SR; Pierre, JM; Saunders, CS; Wirshing, DA; Wirshing, WC | 1 |
Bilici, M; Cakirbay, H; Guler, M; Tan, U; Tosun, M; Ulgen, M | 1 |
DeQuardo, J; Gilani, S; Rajarethinam, R; Tancer, M | 1 |
Miller, DD | 1 |
Conley, RR; Kelly, DL; Love, RC; McMahon, RP | 1 |
Alvir, JM; Kane, JM; Lieberman, JA; Robinson, DG; Sheitman, BB; Woerner, MG | 1 |
Barna, I; Gazdag, G; Iványi, Z; Tolna, J | 1 |
Dwyer, DS; Lu, XH | 1 |
Baldessarini, RJ; Gan, L; Moran-Gates, T; Park, YS; Tarazi, FI; Zhang, K | 1 |
Aukst-Margetić, B; Badanjak, A; Margetić, B | 1 |
Aukst Margetić, B; Margetić, B | 1 |
Duggal, HS | 1 |
Britvić, D; Ille, T; Stanković, Z; Vuković, O | 1 |
Aamodt, EJ; Donohoe, DR; Dwyer, DS; Phan, T; Weeks, K | 1 |
Mihaljević-Peles, A; Mihanović, M; Sagud, M; Silić, A; Zivković, M | 1 |
Goodwin, DG; Lindsay, DS; Strobl, JS | 1 |
de Jong, MH; Van Gool, AR; Zemel, D | 1 |
Gibson, LE; Green, AI; Mesholam-Gately, RI; Seidman, LJ | 1 |
Birky, T; Che, P; Cottingham, C; Jiao, K; Percival, S; Wang, H; Wang, Q; Wang, RX; Zhang, W; Zhou, L | 1 |
Bhattiprolu, AK; Brzustowicz, LM; Clarke, SG; Crosta, CM; Dudzinski, NR; Firestein, BL; Fu, AY; Hernandez, K; Moore, JC; Paradiso, KG | 1 |
Osman, E; Yıldız, M | 1 |
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
3 review(s) available for fluphenazine and clozapine
Article | Year |
---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Correlation between plasma concentration and clinical effect of neuroleptics and antidepressants].
Topics: Amitriptyline; Antidepressive Agents; Antipsychotic Agents; Chlorpromazine; Clozapine; Desipramine; Dibenzazepines; Dose-Response Relationship, Drug; Fluphenazine; Humans; Imipramine; Nortriptyline; Perazine; Phenelzine; Thioridazine | 1976 |
10 trial(s) available for fluphenazine and clozapine
Article | Year |
---|---|
Clinical and biologic response to clozapine in patients with schizophrenia. Crossover comparison with fluphenazine.
Topics: Adult; Antipsychotic Agents; Clozapine; Dopamine; Double-Blind Method; Female; Fluphenazine; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Placebos; Schizophrenia; Schizophrenic Psychology; Serotonin | 1992 |
Predictors of clozapine response in schizophrenia.
Topics: Adult; Antipsychotic Agents; Basal Ganglia Diseases; Clozapine; Double-Blind Method; Female; Fluphenazine; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Probability; Receptors, Neurotransmitter; Schizophrenia; Treatment Outcome | 1994 |
Effects of clozapine, fluphenazine, and placebo on reaction time measures of attention and sensory dominance in schizophrenia.
Topics: Adult; Attention; Auditory Perception; Clozapine; Dominance, Cerebral; Dyskinesia, Drug-Induced; Female; Fluphenazine; Hallucinations; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Reaction Time; Schizophrenia; Schizophrenic Psychology; Visual Perception | 1994 |
Quantitative effects of typical and atypical neuroleptics on smooth pursuit eye tracking in schizophrenia.
Topics: Adult; Attention; Clozapine; Double-Blind Method; Female; Fluphenazine; Humans; Male; Psychiatric Status Rating Scales; Pursuit, Smooth; Saccades; Schizophrenia; Schizophrenic Psychology | 1994 |
Clinical response to clozapine in patients with schizophrenia.
Topics: Clozapine; Dioxanes; Double-Blind Method; Drug Therapy, Combination; Fluphenazine; Hospitalization; Humans; Idazoxan; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology | 1994 |
Effects of clozapine and fluphenazine treatment on responses to m-chlorophenylpiperazine infusions in schizophrenia.
Topics: Adult; Body Temperature; Clozapine; Female; Fluphenazine; Hospitalization; Humans; Hydrocortisone; Infusions, Intravenous; Male; Piperazines; Placebos; Prolactin; Psychiatric Status Rating Scales; Psychotic Disorders; Schizophrenia; Schizophrenic Psychology; Serotonin; Stimulation, Chemical | 1993 |
Idazoxan and response to typical neuroleptics in treatment-resistant schizophrenia. Comparison with the atypical neuroleptic, clozapine.
Topics: Adrenergic alpha-Antagonists; Adult; Antipsychotic Agents; Clozapine; Dioxanes; Double-Blind Method; Drug Therapy, Combination; Female; Fluphenazine; Humans; Idazoxan; Imidazoles; Male; Middle Aged; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Treatment Outcome | 1996 |
The brain metabolic patterns of clozapine- and fluphenazine-treated female patients with schizophrenia: evidence of a sex effect.
Topics: Adult; Animals; Antipsychotic Agents; Cerebral Cortex; Clozapine; Female; Fluphenazine; Humans; Limbic System; Male; Multivariate Analysis; Neostriatum; Schizophrenia; Sex Factors; Tomography, Emission-Computed | 1999 |
Classical and atypical neuroleptics, and bone mineral density, in patients with schizophrenia.
Topics: Adult; Analysis of Variance; Antipsychotic Agents; Benzodiazepines; Bone Density; Clopenthixol; Clozapine; Female; Fluphenazine; Haloperidol; Humans; Male; Olanzapine; Pirenzepine; Risperidone; Schizophrenia | 2002 |
Augmentation of clozapine partial responders with conventional antipsychotics.
Topics: Adult; Antipsychotic Agents; Clozapine; Drug Synergism; Fluphenazine; Haloperidol; Humans; Middle Aged; Schizophrenia; Treatment Outcome | 2003 |
79 other study(ies) available for fluphenazine and clozapine
Article | Year |
---|---|
Synthesis and biological evaluation of some 2-amino-4-aryl-3H-1,5-benzodiazepine analogues of clozapine.
Topics: Adenylyl Cyclase Inhibitors; Animals; Antipsychotic Agents; Avoidance Learning; Brain; Clozapine; Corpus Striatum; Dextroamphetamine; Dibenzazepines; Dopamine; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mice; Rats | 1978 |
Synthesis and central nervous system activity of 2-arylidene-4-aminoalkyl-2H-1,4-benzoxazin-3(4H)-ones and related compounds.
Topics: Adenylyl Cyclase Inhibitors; Animals; Central Nervous System; Depression, Chemical; Female; In Vitro Techniques; Male; Olfactory Bulb; Oxazines; Rats; Receptors, Dopamine; Reflex; Structure-Activity Relationship | 1977 |
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Blotting, Northern; Brain; Cell Line; Cell Membrane; Cloning, Molecular; Dopamine; Humans; Kinetics; Molecular Sequence Data; Molecular Weight; Oligonucleotide Probes; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D5; RNA, Messenger; Sequence Homology, Nucleic Acid; Transfection | 1991 |
(5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(2-fluorophenyl)methanones . A series of novel potential antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Apomorphine; Ataxia; Avoidance Learning; Brain; Cebus; Chemical Phenomena; Chemistry; Dopamine; Male; Mice; Motor Activity; Movement Disorders; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, Dopamine; Saimiri | 1986 |
Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.
Topics: Animals; Antipsychotic Agents; Cell Line; Molecular Structure; Rats; Receptors, Serotonin | 1994 |
H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Discriminant Analysis; Drug Evaluation, Preclinical; Forecasting; Humans; Protein Binding; Receptors, Histamine H1; Statistics, Nonparametric; Weight Gain | 2003 |
Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands.
Topics: Adenylyl Cyclases; Benzoxazines; Cell Line; Humans; Indoles; Ligands; Piperidines; Radioligand Assay; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Structure-Activity Relationship; Sulfonamides | 2005 |
Stable expression of constitutively activated mutant h5HT6 and h5HT7 serotonin receptors: inverse agonist activity of antipsychotic drugs.
Topics: Amino Acid Substitution; Antipsychotic Agents; Cell Line; Cyclic AMP; Humans; Mutagenesis, Site-Directed; Mutation; Radioligand Assay; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Transfection | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Potential utility of histamine H3 receptor antagonist pharmacophore in antipsychotics.
Topics: Animals; Antipsychotic Agents; Cell Line; CHO Cells; Cricetinae; Cricetulus; Histamine Antagonists; Humans; Radioligand Assay; Receptors, Histamine H3 | 2009 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
[The influence of neuroleptic drugs on urinary excretion of non-protein nitrogen (author's transl)].
Topics: Amino Acids; Clopenthixol; Clozapine; Creatinine; Delayed-Action Preparations; Flupenthixol; Fluphenazine; Humans; Hydrogen-Ion Concentration; Ion Exchange Resins; Nitrogen; Procyclidine; Schizophrenia; Thioridazine; Tranquilizing Agents; Urea | 1976 |
Brain homovanillic acid: regional changes over time with antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Brain; Caudate Nucleus; Chlorpromazine; Clozapine; Drug Tolerance; Fluphenazine; Homovanillic Acid; Hypothalamus; Limbic System; Male; Phenylacetates; Rabbits; Thioridazine; Time Factors | 1976 |
Brain homovanillic acid: regional changes following chronic antipsychotic drug administration.
Topics: Animals; Antipsychotic Agents; Brain Chemistry; Chlorpromazine; Clozapine; Drug Tolerance; Fluphenazine; Haloperidol; Homovanillic Acid; Male; Phenylacetates; Rabbits; Thioridazine; Time Factors | 1977 |
Adenylate cyclase from various dopaminergic areas of the brain and the action of antipsychotic drugs.
Topics: Adenylyl Cyclases; Amygdala; Animals; Antipsychotic Agents; Apomorphine; Brain; Caudate Nucleus; Clozapine; Dopamine; Fluphenazine; Isoproterenol; Loxapine; Median Eminence; Norepinephrine; Olfactory Bulb; Rats | 1977 |
The effect of neuroleptic drugs on drinking induced by central administration of angiotensin or carbachol.
Topics: Angiotensin II; Animals; Antipsychotic Agents; Carbachol; Chlorpromazine; Clozapine; Dopamine; Drinking Behavior; Flupenthixol; Fluphenazine; Haloperidol; Injections, Intraperitoneal; Injections, Intraventricular; Male; Pimozide; Rats; Sulpiride | 1979 |
The effect of neuroleptics on brain tyrosine hydroxylase.
Topics: Amitriptyline; Animals; Antidepressive Agents; Antipsychotic Agents; Brain; Clozapine; Fluphenazine; Haloperidol; Hypothalamus; Male; Promethazine; Rats; Tyrosine 3-Monooxygenase | 1978 |
Neuropharmacological and behavioral evaluation of prostaglandin E2 and 11-thiol-11-desoxy prostaglandin E2 in the mouse and rat.
Topics: Animals; Avoidance Learning; Behavior, Animal; Catalepsy; Clozapine; Dextroamphetamine; Fluphenazine; Haloperidol; Humans; Male; Mice; Motor Activity; Physostigmine; Prostaglandins E; Prostaglandins E, Synthetic; Rats; Stereotyped Behavior; Thioridazine | 1978 |
A comparison of the abilities of typical neuroleptic agents and of thioridazine, clozapine, sulpiride and metoclopramide to antagonise the hyperactivity induced by dopamine applied intracerebrally to areas of the extrapyramidal and mesolimbic systems.
Topics: Animals; Brain; Clozapine; Corpus Striatum; Dopamine Antagonists; Dose-Response Relationship, Drug; Extrapyramidal Tracts; Fluphenazine; Haloperidol; Limbic System; Male; Metoclopramide; Pimozide; Rats; Stereotaxic Techniques; Sulpiride; Thioridazine; Tranquilizing Agents | 1976 |
Catecholamine-sensitive adenylate cyclase in frontal cortex of primate brain.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Calcium; Catecholamines; Cerebral Cortex; Clozapine; Dopamine; Drug Combinations; Fluphenazine; Frontal Lobe; Guanosine Triphosphate; Haloperidol; Haplorhini; Isoproterenol; Macaca mulatta; Norepinephrine; Phentolamine; Receptors, Adrenergic; Receptors, Dopamine; Sodium Fluoride; Time Factors | 1976 |
Detection of the nueroleptic properties of clozapine, sulpiride and thioridazine.
Topics: Animals; Apomorphine; Behavior, Animal; Catalepsy; Clozapine; Dextroamphetamine; Dibenzazepines; Dose-Response Relationship, Drug; Drug Synergism; Fluphenazine; Haloperidol; Humans; Isoquinolines; Male; Methyltyrosines; Pimozide; Rats; Spiro Compounds; Stereotyped Behavior; Succinimides; Sulpiride; Thioridazine; Tranquilizing Agents | 1975 |
Plasma homovanillic acid and other predictors of clozapine response.
Topics: Clozapine; Fluphenazine; Homovanillic Acid; Humans; Schizophrenia | 1992 |
The effects of typical and atypical neuroleptics on mitogen-induced T lymphocyte responsiveness.
Topics: Adult; Antigens, Differentiation; Antipsychotic Agents; CD5 Antigens; Clozapine; Female; Fluphenazine; Haloperidol; Humans; Lymphocyte Activation; Male; Schizophrenia; Schizophrenic Psychology; T-Lymphocytes; Thioridazine | 1991 |
Chronic administration of typical, but not atypical neuroleptics induce persisting alterations in rest-activity cycles in rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Drinking; Female; Fluphenazine; Haloperidol; Motor Activity; Raclopride; Rats; Rats, Inbred Strains; Salicylamides | 1990 |
3-Methoxytyramine accumulation: effects of typical neuroleptics and various atypical compounds.
Topics: 4-Butyrolactone; Animals; Antipsychotic Agents; Apomorphine; Benzazepines; Buspirone; Carbazoles; Chlorpromazine; Clozapine; Corpus Striatum; Dopamine; Dopamine Antagonists; Fluphenazine; Haloperidol; Male; Molindone; Pargyline; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Regression Analysis | 1986 |
In vivo potencies of antipsychotic drugs in blocking alpha 1 noradrenergic and dopamine D2 receptors: implications for drug mechanisms of action.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Chlorpromazine; Clozapine; Fluphenazine; Haloperidol; Kinetics; Male; Prazosin; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Thioridazine | 1986 |
Apparent neuroleptic malignant syndrome with clozapine and lithium.
Topics: Adult; Bipolar Disorder; Clozapine; Dibenzazepines; Drug Therapy, Combination; Fluphenazine; Humans; Lithium; Lithium Carbonate; Male; Neuroleptic Malignant Syndrome | 1986 |
Clozapine plasma levels determined by high-performance liquid chromatography with ultraviolet detection.
Topics: Chromatography, High Pressure Liquid; Clozapine; Dibenzazepines; Fluphenazine; Humans; Spectrophotometry, Ultraviolet | 1988 |
Antischizophrenic drugs: affinity for muscarinic cholinergic receptor sites in the brain predicts extrapyramidal effects.
Topics: Animals; Antipsychotic Agents; Basal Ganglia Diseases; Binding, Competitive; Brain; Chlorpromazine; Clozapine; Fluphenazine; Guinea Pigs; Haloperidol; Haplorhini; Humans; In Vitro Techniques; Perphenazine; Phenothiazines; Promazine; Rats; Receptors, Cholinergic; Schizophrenia; Thioridazine; Trifluoperazine; Triflupromazine | 1974 |
Effect of neuroleptics and tricyclic antidepressants upon d-amphetamine discrimination.
Topics: Animals; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Chlorpromazine; Clozapine; Desipramine; Dextroamphetamine; Discrimination, Psychological; Dose-Response Relationship, Drug; Fluphenazine; Haloperidol; Imipramine; Male; Nortriptyline; Promethazine; Rats; Sodium Chloride; Thioridazine; Trifluoperazine | 1980 |
[Treatment of therapeutically resistant paranoid schizophrenic patients with Moditen-depot combined with other psychotropic drugs and Leponex].
Topics: Adolescent; Adult; Antidepressive Agents; Antipsychotic Agents; Clozapine; Delayed-Action Preparations; Depression; Dibenzazepines; Drug Therapy, Combination; Female; Fluphenazine; Humans; Male; Middle Aged; Psychotropic Drugs; Remission, Spontaneous; Schizophrenia, Paranoid | 1980 |
Regional selectivity of neuroleptic drugs: an argument for site specificity.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Corpus Striatum; Fluphenazine; Haloperidol; Limbic System; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Thioridazine | 1983 |
Chronic fluphenazine and clozapine elicit opposite changes in brain muscarinic receptor binding: implications for understanding tardive dyskinesia.
Topics: Animals; Brain; Cerebral Cortex; Choline O-Acetyltransferase; Clozapine; Corpus Striatum; Dibenzazepines; Dyskinesia, Drug-Induced; Fluphenazine; Hippocampus; Male; Mice; Pilocarpine; Quinuclidinyl Benzilate; Receptors, Cholinergic; Receptors, Muscarinic | 1983 |
An examination of methodological refinements, clozapine and fluphenazine in the anhedonia paradigm.
Topics: Animals; Clozapine; Conditioning, Operant; Dibenzazepines; Dose-Response Relationship, Drug; Emotions; Extinction, Psychological; Fluphenazine; Male; Pimozide; Rats; Rats, Inbred Strains; Reinforcement Schedule | 1982 |
Differential effects of classical and newer antipsychotics on the hypermotility induced by two dose levels of D-amphetamine.
Topics: Animals; Antipsychotic Agents; Clozapine; Dextroamphetamine; Dose-Response Relationship, Drug; Fluphenazine; Haloperidol; Imidazoles; Indoles; Locomotion; Male; Motor Activity; Prazosin; Rats; Rats, Wistar; Ritanserin | 1995 |
[Is there a special indication for fluphenazine in therapy refractory hallucinations?].
Topics: Clozapine; Delusions; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluphenazine; Hallucinations; Humans; Schizophrenia; Schizophrenia, Paranoid; Schizophrenic Psychology | 1994 |
Effect of chronic neuroleptic treatment on central and peripheral muscarinic receptors.
Topics: Animals; Antipsychotic Agents; Atropine; Cell Membrane; Clozapine; Corpus Striatum; Fluphenazine; Male; Myocardium; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Time Factors; Urinary Bladder | 1993 |
Clozapine reverses cocaine craving in a treatment-resistant mentally ill chemical abuser: a case report and a hypothesis.
Topics: Adult; Clozapine; Cocaine; Comorbidity; Diagnosis, Dual (Psychiatry); Drug Therapy, Combination; Fluphenazine; Humans; Lithium; Male; Psychotic Disorders; Substance-Related Disorders; Treatment Outcome | 1994 |
Irreversible blockade of D2 dopamine receptors by fluphenazine-N-mustard increases glutamic acid decarboxylase mRNA in rat striatum.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antipsychotic Agents; Base Sequence; Blotting, Northern; Clozapine; Corpus Striatum; Depression, Chemical; Dopamine D2 Receptor Antagonists; Fluphenazine; Glutamate Decarboxylase; Haloperidol; In Vitro Techniques; Male; Molecular Sequence Data; Oligodeoxyribonucleotides; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; RNA Probes; RNA, Messenger | 1993 |
Platelet dysfunction associated with clozapine therapy.
Topics: Amobarbital; Blood Cell Count; Clozapine; Delayed-Action Preparations; Diazepam; Drug Monitoring; Drug Therapy, Combination; Epistaxis; Fluphenazine; Hemoglobins; Humans; Male; Middle Aged; Platelet Count; Schizophrenia, Paranoid; Thrombocytopenia | 1993 |
The interaction of clozapine with the meta-chlorophenylpiperazine (mCPP) discriminative stimulus.
Topics: Animals; Antipsychotic Agents; Clozapine; Discrimination, Psychological; Drug Interactions; Fluphenazine; Piperazines; Rats; Rats, Inbred F344; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin | 1996 |
Cognitive dysfunction in schizophrenia: comparison of treatment with atypical antipsychotic agents and conventional neuroleptic drugs.
Topics: Clozapine; Cognition; Fluphenazine; Haloperidol; Humans; Maze Learning; Risperidone; Schizophrenia | 1996 |
Differential expression of c-fos mRNA in rat prefrontal cortex, striatum, N. accumbens and lateral septum after typical and atypical antipsychotics: an in situ hybridization study.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Brain; Clozapine; Corpus Striatum; Fluphenazine; Genes, fos; Haloperidol; In Situ Hybridization; Nucleus Accumbens; Piperazines; Prefrontal Cortex; Quinolones; Rats; RNA, Messenger; Septum Pellucidum; Sulpiride | 1996 |
The brain metabolic patterns of clozapine- and fluphenazine-treated patients with schizophrenia during a continuous performance task.
Topics: Adult; Auditory Perception; Brain; Clozapine; Deoxyglucose; Fluorodeoxyglucose F18; Fluphenazine; Glucose; Humans; Limbic System; Male; Middle Aged; Prefrontal Cortex; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Task Performance and Analysis; Temporal Lobe; Tomography, Emission-Computed | 1997 |
Attenuation of antipsychotic-induced hyperprolactinemia with clozapine.
Topics: Adolescent; Amenorrhea; Antipsychotic Agents; Bromocriptine; Clozapine; Female; Fluphenazine; Galactorrhea; Haloperidol; Humans; Hyperprolactinemia; Prolactin; Psychotic Disorders; Thioridazine | 1997 |
Effect of clozapine on dopamine-induced inhibition of prolactin release from cultured rat pituitary cells.
Topics: Animals; Antipsychotic Agents; Cells, Cultured; Chlorpromazine; Clozapine; Dopamine; Fluphenazine; Humans; Pituitary Gland; Prolactin; Rats; Receptors, Dopamine | 1997 |
Long-term effects of S(+)N-n-propylnorapomorphine compared with typical and atypical antipsychotics: differential increases of cerebrocortical D2-like and striatolimbic D4-like dopamine receptors.
Topics: Animals; Antipsychotic Agents; Apomorphine; Autoradiography; Cell Line; Cerebral Cortex; Clozapine; Dopamine Agonists; Drug Design; Fluphenazine; Limbic System; Male; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D4 | 1997 |
Norepinephrine and schizophrenia: a new hypothesis for antipsychotic drug action.
Topics: Antipsychotic Agents; Clozapine; Fluphenazine; Humans; Methoxyhydroxyphenylglycol; Norepinephrine; Regression Analysis; Schizophrenia; Time Factors | 1998 |
A histochemical demonstration of altered cytochrome oxidase activity in the rat brain by neuroleptics.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Densitometry; Electron Transport Complex IV; Fluphenazine; Haloperidol; Histocytochemistry; Male; Rats; Rats, Sprague-Dawley | 1998 |
Neuroleptic malignant syndrome during low dosed neuroleptic medication in first-episode psychosis: a case report.
Topics: Adult; Antipsychotic Agents; Clozapine; Dantrolene; Female; Fluphenazine; Humans; Muscle Relaxants, Central; Neuroleptic Malignant Syndrome; Psychotic Disorders | 1999 |
Pentadecapeptide BPC 157 attenuates disturbances induced by neuroleptics: the effect on catalepsy and gastric ulcers in mice and rats.
Topics: Animals; Anti-Ulcer Agents; Antipsychotic Agents; Catalepsy; Clozapine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Fluphenazine; Haloperidol; Male; Mice; Orientation; Peptic Ulcer; Peptide Fragments; Proteins; Rats; Rats, Wistar; Sulpiride; Time Factors | 1999 |
Paradoxical effect of neuroleptic drugs on prolactin secretion by rat pituitary cell cultures.
Topics: Animals; Antipsychotic Agents; Cell Survival; Cells, Cultured; Clozapine; Female; Fluphenazine; Pituitary Gland; Prolactin; Rats; Rats, Wistar; Secretory Rate | 1999 |
Dopamine receptor antagonists modulate glucose uptake in rat pheochromocytoma (PC12) cells.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antipsychotic Agents; Benzazepines; Biological Transport; Chlorpromazine; Clozapine; Dizocilpine Maleate; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Excitatory Amino Acid Antagonists; Fluphenazine; Glucose; Haloperidol; PC12 Cells; Pimozide; Rats; Receptors, Dopamine D2; Spiperone; Sulpiride; Tritium | 1999 |
Thrombocytopenia associated with clozapine and fluphenazine.
Topics: Adult; Antipsychotic Agents; Clozapine; Fluphenazine; Humans; Male; Schizophrenia; Thrombocytopenia | 2001 |
Effects of atypical antipsychotics on vertebrate neuromuscular transmission.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Fluphenazine; In Vitro Techniques; Membrane Potentials; Motor Endplate; Neuromuscular Junction; Olanzapine; Pirenzepine; Rana pipiens; Rana temporaria; Risperidone; Sulpiride; Synaptic Transmission | 2002 |
Sexual side effects of novel antipsychotic medications.
Topics: Adult; Antipsychotic Agents; Clozapine; Erectile Dysfunction; Fluphenazine; Haloperidol; Humans; Male; Middle Aged; Prospective Studies; Psychiatric Status Rating Scales; Risperidone; Schizophrenia; Schizophrenic Psychology; Sexual Behavior | 2002 |
Clozapine and tardive dyskinesia.
Topics: Adult; Antipsychotic Agents; Clozapine; Drug Administration Schedule; Dyskinesia, Drug-Induced; Female; Fluphenazine; Haloperidol; Humans; Longitudinal Studies; Schizophrenia, Paranoid | 2003 |
Rehospitalization risk with second-generation and depot antipsychotics.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Clozapine; Data Collection; Delayed-Action Preparations; Female; Fluphenazine; Haloperidol; Humans; Male; Olanzapine; Patient Readmission; Pirenzepine; Risperidone; Schizophrenia; Secondary Prevention; Time Factors; Treatment Outcome | 2003 |
Clozapine as a first treatment for schizophrenia.
Topics: Adolescent; Adult; Antipsychotic Agents; Clozapine; Drug Administration Schedule; Female; Fluphenazine; Follow-Up Studies; Hospitalization; Humans; Male; Middle Aged; Patient Dropouts; Psychiatric Status Rating Scales; Psychotic Disorders; Schizophrenia; Schizophrenic Psychology; Survival Analysis; Treatment Outcome | 2003 |
The impact of neuroleptic medication on seizure threshold and duration in electroconvulsive therapy.
Topics: Adult; Aged; Antipsychotic Agents; Benzodiazepines; Brain; Clopenthixol; Clozapine; Dibenzothiazepines; Electric Impedance; Electroconvulsive Therapy; Electroencephalography; Electromyography; Female; Fluphenazine; Haloperidol; Humans; Male; Middle Aged; Olanzapine; Quetiapine Fumarate; Risperidone; Seizures; Sulpiride | 2004 |
Second-generation antipsychotic drugs, olanzapine, quetiapine, and clozapine enhance neurite outgrowth in PC12 cells via PI3K/AKT, ERK, and pertussis toxin-sensitive pathways.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Chromones; Clozapine; Dibenzothiazepines; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Fluphenazine; Haloperidol; Humans; Morpholines; Nerve Growth Factor; Neurites; Olanzapine; PC12 Cells; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quetiapine Fumarate; Rats | 2005 |
Repeated antipsychotic drug exposure in developing rats: dopamine receptor effects.
Topics: Age Factors; Animals; Antipsychotic Agents; Autoradiography; Benzodiazepines; Clozapine; Fluphenazine; Image Processing, Computer-Assisted; Male; Olanzapine; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, Dopamine | 2006 |
Importance of oral glucose tolerance test in patient with schizophrenia.
Topics: Adult; Antipsychotic Agents; Clozapine; Drug Therapy, Combination; Fluphenazine; Glucose Tolerance Test; Humans; Male; Schizophrenia; Weight Gain | 2005 |
Switching as only temporal solution for patients with antipsychotic-associated diabetes: further observations.
Topics: Adult; Antipsychotic Agents; Blood Glucose; Body Mass Index; Clozapine; Diabetes Mellitus, Type 2; Dibenzothiazepines; Diet, Diabetic; Drug Therapy, Combination; Female; Fluphenazine; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Mass Screening; Quetiapine Fumarate; Risk Factors; Schizophrenia | 2007 |
Glycopyrrolate for clozapine-induced sialorrhea.
Topics: Adult; Antimanic Agents; Antipsychotic Agents; Clozapine; Fluphenazine; Glycopyrrolate; Humans; Male; Muscarinic Antagonists; Psychotic Disorders; Sialorrhea; Valproic Acid | 2007 |
Treatment compliance of outpatients with schizophrenia: patient's attitudes, demographic, clinical and therapeutic variables.
Topics: Administration, Oral; Adult; Age Factors; Ambulatory Care; Antipsychotic Agents; Clozapine; Cross-Sectional Studies; Delayed-Action Preparations; Female; Fluphenazine; Haloperidol; Health Knowledge, Attitudes, Practice; Humans; Long-Term Care; Male; Middle Aged; Patient Compliance; Psychiatric Status Rating Scales; Risperidone; Schizophrenia; Schizophrenic Psychology; Yugoslavia | 2008 |
Antipsychotic drugs up-regulate tryptophan hydroxylase in ADF neurons of Caenorhabditis elegans: role of calcium-calmodulin-dependent protein kinase II and transient receptor potential vanilloid channel.
Topics: Adaptation, Physiological; Animals; Animals, Genetically Modified; Antipsychotic Agents; Behavior, Animal; Benzodiazepines; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Chloride Channels; Clozapine; Fluphenazine; Microscopy, Fluorescence; Neurons; Olanzapine; Receptors, Serotonin, 5-HT2; Serotonin; Trifluoperazine; TRPV Cation Channels; Tryptophan Hydroxylase; Up-Regulation | 2008 |
The role of CYP2D6 and TaqI A polymorphisms in malignant neuroleptic syndrome: two case reports with three episodes.
Topics: Adult; Alleles; Antipsychotic Agents; Bipolar Disorder; Clozapine; Cytochrome P-450 CYP2D6; Dibenzothiazepines; Drug Therapy, Combination; Fluphenazine; Genetic Carrier Screening; Genotype; Haloperidol; Humans; Lithium Carbonate; Male; Neuroleptic Malignant Syndrome; Perazine; Polymorphism, Genetic; Psychotic Disorders; Quetiapine Fumarate; Receptors, Dopamine D2; Recurrence; Risperidone | 2010 |
Evaluation of five antischizophrenic agents against Toxoplasma gondii in human cell cultures.
Topics: Antipsychotic Agents; Cell Line; Clozapine; Fibroblasts; Fluphenazine; Haloperidol; Humans; Schizophrenia; Thioridazine; Toxoplasma; Toxoplasmosis; Trifluoperazine | 2011 |
Clinical aspects of comorbid schizophrenia and idiopathic Parkinson's disease.
Topics: Antiparkinson Agents; Antipsychotic Agents; Brain; Carbidopa; Catechols; Clozapine; Diagnosis, Differential; Fluphenazine; Follow-Up Studies; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Schizophrenia; Tomography, Emission-Computed, Single-Photon; Treatment Outcome | 2014 |
Schizophrenia and co-occurring substance use disorder: reward, olfaction and clozapine.
Topics: Adult; Antipsychotic Agents; Clozapine; Female; Fluphenazine; Haloperidol; Humans; Male; Middle Aged; Odorants; Psychiatric Status Rating Scales; Reward; Schizophrenia; Schizophrenic Psychology; Smell; Substance-Related Disorders | 2014 |
Diverse arrestin-recruiting and endocytic profiles of tricyclic antipsychotics acting as direct α
Topics: Animals; Antipsychotic Agents; beta-Arrestin 1; beta-Arrestin 2; Caveolin 1; Chlorpromazine; Clozapine; Cyclic AMP; Endocytosis; Fibroblasts; Fluphenazine; Guanosine 5'-O-(3-Thiotriphosphate); HEK293 Cells; Humans; MAP Kinase Signaling System; Mice; Mice, Knockout; Molecular Docking Simulation; Norepinephrine; Receptors, Adrenergic, alpha-2 | 2017 |
Characterization hiPSC-derived neural progenitor cells and neurons to investigate the role of NOS1AP isoforms in human neuron dendritogenesis.
Topics: Adaptor Proteins, Signal Transducing; Cells, Cultured; Clozapine; Dendrites; Drug Evaluation, Preclinical; Fluphenazine; Gene Expression Regulation; Glutamic Acid; Haloperidol; Humans; Induced Pluripotent Stem Cells; Ion Channels; Nerve Tissue Proteins; Neural Stem Cells; Neurons; Oligopeptides; Patch-Clamp Techniques; Protein Isoforms; Schizophrenia; Serine | 2020 |
Letter to the Editor: Rethinking The Cost Of Antipsychotic Treatment: The Average Cost Of The Drugs Used In Turkey In 2020.
Topics: Adenosine Monophosphate; Adult; Amisulpride; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Chlorpromazine; Clopenthixol; Clozapine; Flupenthixol; Fluphenazine; Haloperidol; Humans; Olanzapine; Paliperidone Palmitate; Pharmaceutical Preparations; Pimozide; Quetiapine Fumarate; Risperidone; Sulpiride; Trifluoperazine | 2022 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |