fluorouracil has been researched along with thymidine in 351 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 271 (77.21) | 18.7374 |
| 1990's | 51 (14.53) | 18.2507 |
| 2000's | 19 (5.41) | 29.6817 |
| 2010's | 9 (2.56) | 24.3611 |
| 2020's | 1 (0.28) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, MS; Prusoff, WH; Schinazi, RF | 1 |
| Forsthoefel, PF; Williams, ML | 1 |
| Faufmann, M; MAttern, J; Volm, M; Wayss, K | 1 |
| Chu, BC; Lawley, PD | 1 |
| Baker, MS; Benedict, WF; Heidelberger, C; Jones, PA; Mondal, S; Rapp, U | 1 |
| Pfefferkorn, ER; Pfefferkorn, LC | 1 |
| Pogosiants, EE; Sokova, OI; Volgareva, GM | 1 |
| Cass, CE; Lynch, TP; Paterson, AR | 1 |
| Blend, MJ; Forsthoefel, PF; Snow, JW | 1 |
| Danhauser, L; Rustum, YM; Wang, G | 1 |
| Bowen, D; Diasio, RB; Goldman, ID | 1 |
| Hopkins, HA; Wakefield, JA | 1 |
| DeMarchi, JM; Kaplan, AS | 1 |
| Chavaudra, N; Malaise, EP | 1 |
| Santelli, G; Valeriote, F | 2 |
| Klahr, C; Presant, CA; Ratkin, GA; Vogel, SJ | 1 |
| Friedman, MA; Sadée, W | 1 |
| Goldin, A; Wolpert-Defilippes, MK | 1 |
| Danhauser, LL; Rustum, YM | 2 |
| Carrico, CK; Glazer, RI | 1 |
| Reinhard, P; Schluchter, M | 1 |
| Breland, JC; Carter, GL; Cory, JG | 1 |
| Akao, T; Fujimoto, S; Itoh, B; Itoh, K; Kitsukawa, Y; Takahashi, M | 1 |
| Alexander, JA; Wheeler, GP | 1 |
| Redmann, K; Walliser, S | 1 |
| Gloor, M; Schnyder, UW; Vollweiler, B; Wirth, H | 2 |
| Hoshi, A; Kuretani, K; Yoshida, M | 1 |
| de Loecker, W; van der Schueren, G | 1 |
| Rizki, RM; Rizki, TM | 3 |
| Camplejohn, RS; Maurer, W; Schultze, B | 1 |
| Young, RC | 1 |
| Håkansson, L | 1 |
| Cabradilla, CD; Toliver, AP | 1 |
| Jentzsch, K | 1 |
| Dahn, I; Håkansson, L; Huldt, B | 1 |
| Der, S; Jonek, JJ; Konecki, J | 1 |
| Cohen, AM | 1 |
| Feinendegen, LE; Myers, DK | 1 |
| Chabner, BA; Myers, CE; Young, RC | 1 |
| Fujieda, S; Ohtsubo, T; Saito, H; Tanigawa, N | 1 |
| Arredondo, MA; Guimaraes, MA; Rustum, YM; Yin, MB; Zhang, ZG | 1 |
| Ng, TC; Sijens, PE | 1 |
| Cloos, J; Noordhuis, P; Peters, GJ; Pinedo, HM; Smid, K; van der Wilt, CL | 1 |
| Hoffman, M; O'Connor, CJ; Schwartz, EL; Wadler, S | 1 |
| Grem, JL | 1 |
| Taniki, T; Weber, G; Zhen, YS | 1 |
| Jeyanthi, R; Nagarajan, B; Rao, KP | 1 |
| De Clercq, E; Marquez, VE; Murase, J | 1 |
| Rustum, YM; Yin, MB | 1 |
| Nagai, M; Nakamura, H; Olah, E; Prajda, N; Szekeres, T; Weber, G | 1 |
| Cravo, ML; Mason, JB; Rosenberg, IH; Selhub, J | 1 |
| Glass, J; Neefe, JR | 1 |
| Choo, PH; Kitada, S; Lee, DA; Shapourifar-Tehrani, S; Wong, VK | 1 |
| Hampson, J; Lord, BI; Redmond, S; Slocombe, P | 1 |
| Dvilansky, A; Kafka, M; Nathan, I | 1 |
| Imai, S; Morimoto, H; Nio, Y; Shiraishi, T; Tobe, T; Tseng, CC; Tsubono, M | 1 |
| Holbrook, CT; Klann, RC; Nyce, J | 1 |
| Goldberg, RM; Krook, JE; Kugler, JW; Laurie, JA; Moertel, CG; O'Connell, MJ; Pfeifle, DM; Rubin, J; Wieand, HS; Windschitl, HE | 1 |
| Greenhalgh, DA; Parish, JH | 1 |
| Germain, G; Houghton, JA; Houghton, PJ; Pennington, J; Radparvar, S; Rahman, A | 1 |
| Ichikawa, S; Nagai, M; Natsumeda, Y; Weber, G | 1 |
| Akazawa, S; Ayusawa, D; Kumai, R; Seno, T; Shimizu, K; Yoshida, K | 1 |
| Laurensse, E; Leyva, A; Peters, GJ; Pinedo, HM | 2 |
| Kane, MA; Raptis, G; Roth, E; Schreiber, C; Waxman, S | 1 |
| Arbuck, SG; Creaven, PJ; Herrera, L; Mittelman, A; Petrelli, N; Rustum, YM; Trave, F; Zakrzewski, SF | 1 |
| Milstone, LM; Schwartz, PM | 1 |
| Burdett, DN; Chen, YP; Shah, RM | 1 |
| Darland, G; Kaplan, L; Rosenbach, M | 1 |
| Alcober, V; Pellicer, JA; Pertusa, J | 1 |
| Kusumoto, H; Kusumoto, T; Maehara, Y; Sakaguchi, Y; Sugimachi, K | 1 |
| Farquhar, D; Freed, JJ; Hampton, A | 1 |
| Buroker, TR; Cullinan, SA; Everson, LK; Fleming, TR; Klaassen, DJ; Krook, JE; Laurie, JA; Mailliard, JA; Marschke, RF; Moertel, CG | 1 |
| Armstrong, RD; Cadman, EC; Takimoto, CH | 1 |
| Bollag, W; Hartmann, HR | 1 |
| Bertino, JR; Mini, E; Moroson, BA | 1 |
| Bertino, JR; Coronnello, M; Criscuoli, L; Gualtieri, M; Mazzei, T; Mini, E; Periti, P | 1 |
| Lönn, S; Lönn, U | 1 |
| Lin, FH; Williams, WM | 1 |
| Fantes, F; Hajek, AS; Mallick, KS; Parrish, RK; Rivera, AH | 1 |
| Hattori, T; Hirabayashi, N; Niimi, K; Niimoto, M; Nishiyama, M; Noso, Y; Toge, T; Yamaguchi, M | 1 |
| Hattori, T; Hirabayashi, N; Niimoto, M; Nishiyama, M; Nosoh, Y; Toge, T; Yamaguchi, M | 1 |
| Abe, Y; Ido, T; Ishiwata, K; Matsuzawa, T; Murakami, M | 1 |
| Benedict, WF; Heidelberger, C; Peterson, AR | 1 |
| Srivastava, BI | 1 |
| Hoth, DF; King, SA; Leyland-Jones, B; O'Dwyer, PJ | 1 |
| Bitny-Szlachto, S; Panfil, B | 1 |
| Leyland-Jones, B; O'Dwyer, PJ | 1 |
| Inokuchi, K; Maehara, Y; Masuda, H; Matsuoka, H; Sugimachi, K | 1 |
| Fischer, PH; Grem, JL | 1 |
| Alama, A; Canavese, G; Conte, PF; Di Marco, E; Nicolin, A; Rosso, R | 1 |
| O'Dea, RF; Ramnaraine, ML; Tuchman, M | 2 |
| Meyer, JS | 1 |
| Kennedy, KA; Klubes, P; Parker, WB | 1 |
| Germain, G; Houghton, JA; Houghton, PJ; Torrance, PM | 1 |
| el-Assouli, SM | 1 |
| Rustum, YM | 1 |
| Gonçalves, O; Meuth, M; Trudel, M | 1 |
| Ashman, CR; Davidson, RL; Kaufman, ER | 1 |
| Balzarini, J; Bricaud, H; De Clercq, E; Desgranges, C; Drouillet, F; Herdewijn, P; Razaka, G | 1 |
| Akazawa, S; Ayusawa, D; Kumai, R; Seno, T; Shimizu, K; Yoshida, S | 1 |
| Chun, H; Kemeny, N; Lynch, G; Martin, D; Young, C | 1 |
| Bedikian, A; Bodey, GP; Chiuten, DF; Freireich, EJ; Valdivieso, M | 1 |
| Hajek, AS; Mallick, KS; Parrish, RK | 1 |
| Bedikian, A; Benvenuto, JA; Bodey, GP; Chiuten, DF; Freireich, EJ; Loo, TL; Miller, A; Valdivieso, M | 1 |
| Conte, PF; Drewinko, B; Fraschini, G | 1 |
| Kanamoto, Y | 1 |
| Briggs, L; Parry, N; Recher, L; Whitescarver, J | 1 |
| Galt, RM; Knock, FE; Oester, YT; Sylvester, R | 2 |
| Doolittle, CH; Hahn, GA; Mandel, HG | 1 |
| Haki, K; Iwasa, H; Murakami, T; Sekizuka, H | 1 |
| Goerttler, K; Kaufmann, M; Mattern, J; Volm, M; Wayss, K | 1 |
| Seidel, HJ; Wegner, LA | 1 |
| Wüst, GP | 1 |
| Hahn, GA; Mandel, HG | 1 |
| Bresler, SK; Mosevitskii, MI; Vyacheslavov, LG | 1 |
| Craig, JM; Kury, G | 1 |
| Beridze, TG; Cherkashina, NA; Odintsova, MS; Sissakian, NM | 1 |
| Foley, GE; Lazarus, H | 1 |
| Wolberg, WH | 3 |
| Hoshino, T; Nagai, M; Sano, K | 1 |
| Seeber, S; Warnecke, P; Weitzel, G | 1 |
| Kummer, D | 1 |
| Beck, CF; Ingraham, JL; Neuhard, J; Thomassen, E | 1 |
| Williams, JP | 1 |
| Hanna, C | 1 |
| Bremer, K; Pinney, RJ; Smith, JT | 1 |
| Ben-Porat, T; Kaplan, AS; Tennant, RW | 1 |
| Bensch, KG; Fong, CK; Hsiung, GD | 1 |
| Foltz, EL | 1 |
| Baba, K; Minekawa, Y; Takahashi, M | 1 |
| Birg, F; Meyer, G | 1 |
| Dickson, JA; Suzangar, M | 1 |
| Erbe, J; Plagemann, PG | 1 |
| Bullock, J; Khalil, FL; Lea, MA; Morris, HP | 1 |
| Clarkson, SG | 1 |
| Bean, B; Tomasz, A | 1 |
| Mikhailova, LN; Zalmanzon, ES | 1 |
| Bull, FE; Ruddon, RW; Wheeler, RH | 1 |
| Krishnan, D; Painter, RB | 1 |
| Harrap, KR; Tattersall, MH | 1 |
| Rosenbaum-Oliver, D; Zamenhof, S | 1 |
| Boyle, JM | 1 |
| Bolund, C; Sköld, O | 1 |
| Schlammadinger, J; Szabó, G | 1 |
| Curry, MC; Dustin, R; Kahn, G | 1 |
| Lipkin, M; Troncale, FJ | 1 |
| Peckham, MJ | 1 |
| Douthit, HA; Rizki, RM; Rizki, TM | 1 |
| Leskova, S; Merkulov, M | 1 |
| Johanson, KJ | 1 |
| Aingorn, ED; Akif'ev, AP | 2 |
| Edlis, H; Herbert, V; Tisman, G | 1 |
| Lee, TC; Maruyama, Y; Sullivan, S | 1 |
| Ganzer, U; Nitze, HR; Vosteen, KH | 1 |
| Painter, RB; Young, BR | 1 |
| Bärwolff, D; Langen, P; Matthes, E | 1 |
| Mattern, J; Volm, M; Wayss, K | 1 |
| Birkett, S; Salaman, DF | 1 |
| Benckhuijsen, C | 1 |
| Velousova, AK | 1 |
| Sköld, O | 1 |
| Boyle, JM; Schenley, RL; Swenson, PA | 1 |
| Mueller, M; Russo, V; Selzer, G; Stahl, FW; Yegian, CD | 1 |
| Mandel, HG; Reich, M | 1 |
| Hogg, L; Kemp, S; Wachsman, JT | 1 |
| Bloch, A; Fleysher, MH; Hall, RH; Maue, RJ; Thedford, R | 1 |
| Bass, RE; Saunders, GF; Saunders, PP | 1 |
| Baranski, K; Bardos, TJ; Bloch, A; Kalman, TI | 1 |
| Hand, RE; Tennant, RW | 1 |
| Leskova, SG; Merkulov, MF | 1 |
| Bruce, WR; Eaves, AC | 1 |
| Cooper, GM; Dunning, WF; Greer, S | 1 |
| Blunt, RJ; Jones, R | 1 |
| Rowe-Jones, DC | 1 |
| Nitze, HR; Rosemann, G | 1 |
| Greenberg, DM; Reeves, WJ; Seid, A | 1 |
| Hall, TC; Kessel, D; Reyes, P | 1 |
| Hara, H | 1 |
| Hong, CI; Irvin, JL; Piantadosi, C | 1 |
| Ansfield, FJ; Wolberg, WH | 1 |
| Fujimoto, S; Miyoshi, T; Watanabe, Y; Watanuki, S | 1 |
| Bielka, H; Langen, P; Stahl, J | 1 |
| McGuire, WL; O'Malley, BW | 1 |
| Chae, CB; Irvin, JL; Piantadosi, C | 1 |
| Bruce, WR; Madoc-Jones, H | 1 |
| Garvey, BI; Hayashi, TT | 1 |
| Kowollik, G; Langen, P | 1 |
| Galun, E; Torrey, JG | 1 |
| Herbert, V; Waxman, S | 1 |
| Baserga, R; McDonough, M; Sasaki, T; Shimkin, MB; Thatcher, D; Wieder, R | 1 |
| Astaldi, G; Eridani, S; Giangrande, A; Ponti, GB; Valentini, R | 1 |
| Jordan, RL; Schumacher, H; Wilson, JG | 1 |
| Jordan, RL; Schumacher, HJ; Wilson, JG | 1 |
| Cailleau, R; Reeves, WJ | 1 |
| Ben-Porat, T; Kamiya, T; Kaplan, AS | 1 |
| Booth, BA; Sartorelli, AC | 1 |
| Clarkson, B; O'Connor, A; Ohkita, T; Ota, K | 1 |
| Galun, E; Gressel, J | 1 |
| Green, WR; Lis, AW | 1 |
| Bruce, WR | 1 |
| Gallant, JA; Weisberg, RA | 1 |
| Adams, JE; Breed, NL; Valenti, C | 1 |
| Myers, CE | 1 |
| Cerna, I; Klubes, P; Meldon, MA | 1 |
| Mandel, HG | 1 |
| Ellims, PH | 1 |
| Maurer-Schultze, B | 1 |
| Dolnick, BJ; Pink, JJ | 1 |
| Benz, C; Cadman, E; Choti, M; Newcomer, L | 1 |
| Engelbrecht, C; Lewan, L; Ljungquist, I; Yngner, T | 1 |
| Au, JL; Creaven, PJ; Ledesma, EJ; Mittelman, A; Rustum, YM | 1 |
| Egan, E; Herrick, D; Kufe, DW; Major, PP | 1 |
| Kimura, K; Tanaka, M; Yoshida, S | 1 |
| Cooper, AJ; Goeting, N; Morgan, GR; Taylor, I; Trotter, GA | 1 |
| Powis, G | 1 |
| Teufel, G | 1 |
| Shapiro, WR; Young, DF | 1 |
| Allegra, CJ; Chabner, BA; Curt, GA; Fine, RL; Yeh, GW | 1 |
| Fujii, S; Shirasaka, T | 1 |
| Burchenal, D; Clarkson, BD; Fried, J; Murgo, AJ; Strife, A; Vale, KL; Woodcock, T; Young, CW | 1 |
| Fukuoka, K; Ishitsuka, H; Itoga, A; Maruyama, HB; Miwa, M; Takemoto, K | 1 |
| Day, JL; Mandel, HG; Maybaum, J; Sadee, W; Ullman, B | 1 |
| Au, J; Creaven, P; Mittelman, A; Petrelli, NJ; Rustum, Y; Sternberg, A | 1 |
| Hahn, RG; Kvols, LK; Moertel, CG; O'Connell, MJ; Rubin, J; Schutt, AJ | 1 |
| Mackinnon, WB; Nott, SE; Piper, AA; Tattersall, MH | 1 |
| Hoshino, T; Kobayashi, S | 1 |
| Clarkson, BD; Doblin, JM; Fried, J; Perez, AG | 2 |
| Casper, ES; Kemeny, N; Martin, DS; Michaelson, RA; Young, CW | 1 |
| Langen, P; Liermann, B; Matthes, E | 1 |
| Boumah, CE; Kaplan, JG; Setterfield, G | 1 |
| Leyva, A; Pinedo, HM; Schornagel, JH | 1 |
| Benvenuto, J; Drewinko, B; Freireich, EJ; Ho, DH; Loo, TL; Yang, LY | 1 |
| Fujii, S; Fukushima, M; Ikenaka, K; Kitano, S; Maehara, Y; Nakamura, H; Shirasaka, T | 1 |
| Arking, R; Kalata, K; Parente, A | 1 |
| Jellinghaus, W; Maurer, W; Müller, V; Schultze, B; Weis, G | 1 |
| Tschiersch, B | 1 |
| Tattersall, MH | 1 |
| Covey, JM; Straw, JA | 1 |
| Martin, D; Nayak, R; Ritzi, E; Sawyer, R; Spiegelman, S; Stolfi, R | 1 |
| Evans, RM; Hakala, MT; Laskin, JD | 1 |
| Martin, DS; Nayak, R; Sawyer, RC; Spiegelman, S; Stolfi, RL; Woodcock, T; Young, CW | 1 |
| Au, JL; Danhauser, L; Luccioni, C; Rustum, YM | 1 |
| Al-Jurf, AS | 1 |
| Gonçalves, O; Meuth, M; Thom, P | 1 |
| Eiselt, M; Gloor, M; Wirth, H | 1 |
| Clarke, R; Murphy, RF; Van den Berg, HW | 1 |
| Carlsson, J; Malmqvist, M; Nederman, T | 1 |
| Nissen, E; Tanneberger, S | 1 |
| Brockman, RW; DuBois, NF; Frye, JL; Shaddix, SC; Shealy, YF | 1 |
| Martin, DS; Woodcock, TM; Young, CW | 1 |
| Ensminger, W; Frei, E; Kirkwood, JM; Papathanasopoulos, N; Rosowsky, A | 1 |
| Martin, D; Nayak, R; Sawyer, R; Spiegelman, S; Stolfi, R | 1 |
| Damin, LA; Kemeny, NE; Martin, DS; Woodcock, TM; Young, CW | 1 |
| Hopkins, HA; Looney, WB; Moore, JV | 1 |
| Martin, DS; Nayak, R; Sawyer, RC; Spiegelman, S; Stolfi, RL | 1 |
| Gans, JH; Smuckler, EA | 1 |
| Filov, VA; Reztsova, VV; Stukov, AN | 1 |
| Holland, JF; Mandel, E; Martin, DS; Ohnuma, T; Roboz, J; Waxman, S | 1 |
| Henson, E; McClarty, G; Wang, LL | 1 |
| Komada, Y; Sakai, H; Sakatoku, H; Sakurai, M; Tanaka, S; Xue, HL; Zhang, XL; Zhou, YW | 1 |
| Bicknell, R; Harris, AL; Moghaddam, A; Patterson, AV; Stratford, IJ; Talbot, DC; Zhang, H | 1 |
| Andreola, S; Benini, E; Brambilla, C; Daidone, MG; Ferrari, L; Greco, M; Luisi, A; Mastore, M; Silvestrini, R; Veneroni, S | 1 |
| Aiba, K; Allegra, CJ; Chu, E; Copur, S; Drake, JC | 1 |
| Hu, JL; Qi, CQ; Su, J; Zhen, YC | 1 |
| Allegra, CJ; Geoffroy, FJ; Grem, JL; Sinha, B | 1 |
| Morris, DL; Romani, R | 1 |
| Alama, A; Camoriano, A; Campora, E; Gardin, G; Meazza, R; Merlini, L; Naso, C; Pronzato, P; Repetto, L; Rosso, R | 1 |
| Handschumacher, RE; Pizzorno, G; Sun, Z | 1 |
| Davis, MA; Lawrence, TS; Maybaum, J | 1 |
| Bamberger, U; Chen, HX; Cheng, YC; Guo, X; Heckel, A | 1 |
| Heiden, T; Lewin, F; Skog, S; Tribukait, B | 1 |
| Kajimura, N; Miyazaki, N; Ohkura, H; Okazaki, N | 1 |
| Bierkens, J; Borremans, B; Falla, N; Schoeters, G; Van Gorp, U | 1 |
| Abbott, BD; Buckalew, AR; Elstein, KH; Kavlock, RJ; Lau, C; Logsdon, TR; Setzer, W; Zucker, RM | 1 |
| Baumgart, F; Köpf-Maier, P; Tausch-Treml, R; Ziessow, D | 1 |
| Horowitz, R; Schwartz, EL; Wadler, S | 1 |
| Baldini, E; Bevilacqua, G; Collecchi, P; Conte, PF; Giannessi, PG; Naccarato, AG; Passoni, A | 1 |
| Hickman, JA; Jackman, AL; Potten, CS; Pritchard, DM; Watson, AJ | 1 |
| Amadori, A; Amadori, D; Amaducci, L; Giunchi, DC; Maltoni, R; Nanni, O; Saragoni, A; Silvestrini, R; Vio, A; Volpi, A | 1 |
| Ishida, R; Ito, S; Koda, A; Mori, H; Nagai, H; Nakayama, K | 1 |
| Esaki, T; Fujishima, H; Kondo, T; Masumoto, N; Nakano, S; Niho, Y; Tatsumoto, T | 1 |
| Elstein, KH; Kavlock, RJ; Lau, C; Mole, ML; Rogers, JM; Setzer, RW; Zucker, RM | 1 |
| Boisteau, O; Cordel, S; Grégoire, M; Heymann, MF; Le Pendu, J; Meflah, K; Oliver, L | 1 |
| Peters, GJ; Pinedo, HM; van Groeningen, CJ | 1 |
| Griffiths, JR; Judson, IR; Leach, MO; McSheehy, PM; Ojugo, AS; Rodrigues, LM; Seymour, MT | 1 |
| Cao, S; McGuire, JJ; Rustum, YM | 1 |
| Calvert, H; Hughes, A | 1 |
| Allegra, CJ; Behan, K; Danenberg, KD; Danenberg, PV; Drake, J; Grem, JL; Monks, A; Nguyen, D; Parr, A; Young, L | 1 |
| Backus, HH; Bunni, MA; Comijn, L; Jackman, AL; Jansen, G; Mitchell, F; Peters, GJ; Priest, DG; Smid, K; van der Wilt, CL; Veerman, G; Voorn, DA; Wouters, D | 1 |
| Kojima, T; Miwa, M; Naruse, T | 1 |
| Drouin, R; Lavoie, J | 1 |
| FIELD, EO; KRISS, JP; TUNG, LA | 1 |
| GEISSLER, E | 1 |
| SALZMAN, NP; SEBRING, ED | 1 |
| NICHOL, CA; WHITE, PJ | 1 |
| GOLDE, A; VIGIER, P | 1 |
| GOODMAN, F | 1 |
| DUMONT, AE; SOHN, N | 1 |
| KAPLAN, HS; MARCOVICH, H | 1 |
| DUBBS, DR; KIT, S; PIEKARSKI, LJ | 1 |
| DUBBS, DR; KIT, S | 1 |
| BRUES, AM; MCDONALD, GO; STROUD, AN; SVOBODA, BR | 1 |
| MILLER, E; SULLIVAN, RD | 1 |
| BOND, SB; KRISS, JP | 1 |
| BADER, JP | 1 |
| KAPLAN, AS | 1 |
| BENSON, JW; DAMM, H; DESPREZ, JD; KIEHN, CL | 1 |
| CASSHYAP, P; RAZZELL, WE | 1 |
| BUSCH, H; SMITH, SJ | 1 |
| BODMER, WF; GRETHER, S | 1 |
| MORSE, PA; POTTER, VR | 1 |
| MOURAD, EB | 1 |
| EDLIN, G | 1 |
| BASCH, RS; KARNOFSKY, DA | 1 |
| D'Costa, SS; Hurwitz, JL | 1 |
| Ahn, JM; Kim, JH; Lee, HC; Lee, SN | 1 |
| Antony, S; Gmeiner, WH; Kohlhagen, G; Liao, ZY; Pommier, Y; Sordet, O; Zhang, HL | 1 |
| Aboagye, E; Pillai, RG; Price, P; Yau, K | 1 |
| Al-Salabi, MI; Candlish, D; de Koning, HP; Gudin, S; Jarvis, SM; Quashie, NB; Ranford-Cartwright, LC | 1 |
| Cricca, S; de Bruin, M; Laan, AC; Masterson, AJ; Noordhuis, P; Peters, GJ; Temmink, OH; Turksma, AW | 1 |
| Clarke, SJ; Hoskins, J; Li, KM; Rivory, LP; Sharma, R | 1 |
| Bowie, MB; Eaves, CJ; Hoodless, PA; Kent, DG; McCaffrey, L; McKnight, KD | 1 |
| Cassidy, J; Collie-Duguid, ES; McLeod, HL; Wang, W | 1 |
| Besier, S; Brade, V; Dehghani, F; Loitsch, S; Saum, SH; Wichelhaus, TA; Zander, J | 1 |
| Gustafsson, SB; Jacobsson, SO; Jonsson, M; Lindgren, T | 1 |
| Balzarini, J; Berndsen, SC; Direcks, WG; Lammertsma, AA; Molthoff, CF; Peters, GJ; Proost, N; Spreeuwenberg, MD | 1 |
| Deng, J; Fazzone, W; LaBonte, MJ; Ladner, RD; Neamati, N; Wilson, PM | 1 |
| Brody, JR; Costantino, CL; Eshleman, JR; Gallmeier, E; Hucl, T; Kern, SE; van der Heijden, MS; Wikiewicz, AK; Winter, JM; Yeo, CJ; Zhu, H | 1 |
| Brazowski, E; Eisenthal, A; Eytan, K; Gitstein, G; Greenberg, R; Skornick, Y | 1 |
| Banerjee, D; Bertino, JR; Blasberg, RG; Cai, S; de Stanchina, E; Kochetkov, T; Moroz, MA; Nair, J; Schwartz, GK; Serganova, I; Shamis, M; Wu, J | 1 |
| Doseth, B; Kavli, B; Krokan, HE; Pettersen, HS; Slupphaug, G; Svaasand, EK; Vågbø, CB; Visnes, T | 1 |
| Dingler, FA; Kemmerich, K; Neuberger, MS; Rada, C | 1 |
| Basílio Janke, EM; Weisz, K | 1 |
| Abel, G; Barthelmes, J; Dueregger, A; Guggenberger, F; Haunschild, J; Intelmann, D; Klocker, H; Ramoner, R; Sampson, N; Schuh, M; Stecher, G | 1 |
| Chang, ML; Chen, YC; Chien, RN; Hsu, CW; Lin, CL; Yeh, C; Yeh, CT | 1 |
| Bešker, N; D'Abramo, M; Gentili, P; Giansanti, L; Gradella Villalva, D; La Bella, A; Leonelli, F; Mancini, G; Petaccia, M | 1 |
| Dong, Y; Guan, Z; Niu, B; Wang, J; Wang, X; Zhu, Z | 1 |
| Aboagye, EO; Doblas, S; Döring, C; Faber, C; Fricke, IB; Griffiths, JR; Heinzmann, K; Heller, A; Hermann, S; Honess, DJ; Jacobs, AH; Just, N; Rieder, N; Schäfers, KP; Schelhaas, S; Schneider, R; Sinkus, R; Smith, DM; Wachsmuth, L | 1 |
| Reigan, P; Warfield, BM | 1 |
23 review(s) available for fluorouracil and thymidine
| Article | Year |
|---|---|
The fluoropyrimidines: biochemical mechanisms and design of clinical trials.
Topics: Antineoplastic Agents; Drug Therapy, Combination; Fluorouracil; Humans; Leucovorin; Metabolism; Methotrexate; Pyrimidines; Thymidine; Thymine | 1978 |
Biochemical modulation of fluorouracil by dipyridamole: preclinical and clinical experience.
Topics: Colonic Neoplasms; Deoxyuridine; Dipyridamole; DNA Damage; DNA, Neoplasm; Drug Interactions; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Methotrexate; Nucleosides; Nucleotides; RNA, Neoplasm; Thymidine; Tumor Cells, Cultured; Uridine Monophosphate | 1992 |
Oncogenic transformation of C3H/10T1/2 Cl 8 mouse embryo fibroblasts by inhibitors of nucleotide metabolism.
Topics: Animals; Bromodeoxyuridine; Cell Line; Cell Transformation, Neoplastic; Cytidine; Deoxycytidine; Deoxyribonucleotides; DNA; Embryo, Mammalian; Fibroblasts; Floxuridine; Fluorouracil; Idoxuridine; Methotrexate; Mice; Mice, Inbred C3H; Mutation; Thymidine; Trifluridine | 1985 |
Role of thymidine in biochemical modulation: a review.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cytarabine; Deoxycytidine Kinase; DNA Replication; DNA, Neoplasm; Drug Evaluation; Drug Synergism; Fluorouracil; Folic Acid Antagonists; Humans; Interphase; Kinetics; Leukemia; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Nucleic Acid Synthesis Inhibitors; Nucleotides; Phosphonoacetic Acid; RNA, Neoplasm; Species Specificity; Thymidine | 1987 |
Biochemical modulation: application of laboratory models to the clinic.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cytarabine; Dose-Response Relationship, Drug; Drug Evaluation; Fluorouracil; Humans; Methotrexate; Neoplasms, Experimental; Organophosphorus Compounds; Phosphonoacetic Acid; Thymidine | 1986 |
The genetic consequences of the Thy- mutation to CHO cells.
Topics: Adenine Phosphoribosyltransferase; Alkylating Agents; Animals; Carbon-Nitrogen Ligases; Cell Line; Cricetinae; Cytarabine; Cytidine Triphosphate; Deoxycytosine Nucleotides; Deoxyribonucleotides; DNA; Drug Resistance; Female; Fluorouracil; Genes; Hypoxanthine Phosphoribosyltransferase; Ligases; Mutation; Ovary; Phenotype; Thymidine; Thymine Nucleotides; Ultraviolet Rays | 1985 |
Bromodeoxyuridine mutagenesis and deoxyribonucleotide pool imbalance in mammalian cells.
Topics: Animals; Base Composition; Bromodeoxyuridine; Cell Line; Cricetinae; Cytarabine; Deoxyadenosines; Deoxycytidine; Deoxyguanosine; Deoxyribonucleotides; DNA; Drug Resistance; Fluorouracil; Hydroxyurea; Melanoma; Mutation; Ribonucleotide Reductases; Sister Chromatid Exchange; Thymidine | 1985 |
The cell cycle and the development of pathology in the gastrointestinal tract.
Topics: Adenine; Animals; Autoradiography; Cell Count; Cell Division; Colon; Digestive System; DNA; Flucytosine; Fluorouracil; Humans; Intestine, Small; Methotrexate; Pentosyltransferases; RNA; Stomach; Thymidine; Thymidine Kinase; Tritium | 1972 |
Obstacles to the improvement of radiotherapy of rectal cancer.
Topics: Adenocarcinoma; Animals; Cyclophosphamide; Fluorouracil; Humans; Laparotomy; Lymphography; Methods; Neoplasms, Experimental; Prognosis; Rectal Neoplasms; Thymidine; Tritium | 1973 |
Chemotherapy and the life cycle of leukaemic cells. A comparison between the growth characteristics of human acute leukaemia and the murine leukaemia L 1210.
Topics: Anilides; Animals; Cell Division; Cyclophosphamide; Cytarabine; DNA, Neoplasm; Fluorouracil; Humans; Hydroxyurea; In Vitro Techniques; Leukemia; Leukemia L1210; Leukemia, Lymphoid; Mechlorethamine; Mercaptopurine; Methotrexate; Mice; Mitosis; Nitroso Compounds; Prednisone; Thymidine; Time Factors; Tritium; Vinblastine; Vincristine | 1969 |
[Various aspects of the problem of selectivity in the chemotherapy of cancer].
Topics: Animals; Antimetabolites; Antineoplastic Agents; Chemical Phenomena; Chemistry; DNA, Neoplasm; Fluorouracil; Mercaptopurine; Molecular Biology; Neoplasms, Experimental; Nucleotides; Pyridines; Pyrimidines; RNA, Neoplasm; Thymidine; Transferases | 1969 |
The pharmacology of the fluoropyrimidines.
Topics: Animals; Chemical Phenomena; Chemistry; Deoxyuracil Nucleotides; Flucytosine; Fluorodeoxyuridylate; Fluorouracil; Fungi; Humans; Kinetics; RNA; Thymidine; Thymidylate Synthase | 1981 |
The target cell determinants of the antitumor actions of 5-FU: does FU incorporation into RNA play a role?
Topics: Animals; DNA, Bacterial; DNA, Neoplasm; Fluorodeoxyuridylate; Fluorouracil; Mice; Neoplasms, Experimental; RNA, Bacterial; RNA, Neoplasm; Thymidine | 1981 |
Thymidine as an anticancer agent, alone or in combination. A biochemical appraisal.
Topics: Animals; Antineoplastic Agents; Azacitidine; Cytarabine; Decitabine; Drug Therapy, Combination; Fluorouracil; Humans; Methotrexate; Neoplasms; Thymidine | 1982 |
Dose-dependent metabolism, therapeutic effect, and toxicity of anticancer drugs in man.
Topics: Alanine; Antineoplastic Agents; Cytarabine; Dose-Response Relationship, Drug; Doxorubicin; Fluorouracil; Humans; Ifosfamide; Kinetics; Methotrexate; Thymidine | 1983 |
Neurological complications of antineoplastic therapy.
Topics: Adrenal Cortex Hormones; Alkylating Agents; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Aspartic Acid; Cisplatin; Cytarabine; Fluorouracil; Humans; Methotrexate; Nervous System Diseases; Phosphonoacetic Acid; Thymidine; Vinblastine; Vincristine | 1984 |
Is there a role for thymidine in cancer chemotherapy?
Topics: Cytarabine; Drug Therapy, Combination; Fluorouracil; Humans; Kinetics; Leukemia; Methotrexate; Neoplasms; Thymidine | 1982 |
Treatment of cultured human colon carcinoma cells with fluorinated pyrimidines.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; Culture Media; Drug Evaluation, Preclinical; Fluorouracil; Humans; Tegafur; Thymidine; Uridine | 1980 |
[Metabolic modulation as a method in tumor chemotherapy].
Topics: Antineoplastic Agents; Cytarabine; Fluorouracil; Humans; Methotrexate; Neoplasms; Tegafur; Thymidine; Uracil | 1982 |
An overview of thymidine.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Clinical Trials as Topic; Cytarabine; DNA, Neoplasm; Drug Therapy, Combination; Fluorouracil; Humans; Methotrexate; Methylthioinosine; Mice; Neoplasms; Thymidine | 1980 |
Determinants of response to antimetabolites and their modulation by normal purine and pyrimidine metabolites.
Topics: Animals; Antimetabolites, Antineoplastic; Cytarabine; DNA, Neoplasm; Fluorodeoxyuridylate; Fluorouracil; Humans; Leukemia L1210; Neoplasms; Neoplasms, Experimental; Thymidine; Thymidylate Synthase; Uridine | 1981 |
Modulation of 5-fluorouracil by interferon: a review of potential cellular targets.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Combined Modality Therapy; Fluorouracil; Humans; Interferons; Neoplasms; Neovascularization, Pathologic; Thymidine; Thymidine Phosphorylase; Thymidylate Synthase; Tumor Cells, Cultured | 1995 |
Multifunctional role of thymidine phosphorylase in cancer.
Topics: Fluorouracil; Humans; Neoplasms; Neovascularization, Pathologic; Thymidine; Thymidine Phosphorylase | 2022 |
10 trial(s) available for fluorouracil and thymidine
| Article | Year |
|---|---|
Phase I study of thymidine plus 5-fluorouracil infusions in advanced colorectal carcinoma.
Topics: Clinical Trials as Topic; Colonic Neoplasms; Drug Evaluation; Drug Therapy, Combination; Female; Fluorouracil; Humans; Middle Aged; Rectal Neoplasms; Thymidine | 1979 |
A clinical trial of biochemical modulation of 5-fluorouracil with N-phosphonoacetyl-L-aspartate and thymidine in advanced gastric and anaplastic colorectal cancer.
Topics: Adult; Aged; Aspartic Acid; Clinical Trials as Topic; Colorectal Neoplasms; Drug Evaluation; Drug Synergism; Female; Fluorouracil; Follow-Up Studies; Humans; Male; Middle Aged; Phosphonoacetic Acid; Stomach Neoplasms; Thymidine | 1990 |
A controlled evaluation of recent approaches to biochemical modulation or enhancement of 5-fluorouracil therapy in colorectal carcinoma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colonic Neoplasms; Drug Evaluation; Female; Fluorouracil; Humans; Levamisole; Male; Middle Aged; Neoplasm Metastasis; Phosphonoacetic Acid; Random Allocation; Rectal Neoplasms; Semustine; Streptozocin; Thymidine; Vincristine | 1985 |
UV protective effects of 5-fluorouracil and thymidine.
Topics: Absorption; Candida albicans; Fluorouracil; Humans; Radiation Effects; Radiation-Protective Agents; Skin; Thymidine; Time Factors; Ultraviolet Rays | 1973 |
Cancer chemotherapy. Progress and expectations, 1984.
Topics: Antineoplastic Agents; Clinical Trials as Topic; Cytarabine; Drug Resistance; Fluorouracil; Humans; Neoplasms; Thymidine; Time Factors | 1984 |
Current studies of methotrexate and 5-fluorouracil and their interaction in human tumor cells.
Topics: Animals; Cells, Cultured; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Fluorouracil; Head and Neck Neoplasms; Humans; Leukemia L1210; Methotrexate; Mice; Neoplasm Transplantation; Purines; Random Allocation; Thymidine | 1983 |
An overview of thymidine.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Clinical Trials as Topic; Cytarabine; DNA, Neoplasm; Drug Therapy, Combination; Fluorouracil; Humans; Methotrexate; Methylthioinosine; Mice; Neoplasms; Thymidine | 1980 |
Changes in biological markers after primary chemotherapy for breast cancers.
Topics: Aneuploidy; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Breast Neoplasms; Cell Cycle; Cell Division; Cyclophosphamide; Diploidy; DNA, Neoplasm; Doxorubicin; Epirubicin; Female; Fluorouracil; Humans; Methotrexate; Mitoxantrone; Neoplasm Staging; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; S Phase; Thymidine; Tumor Suppressor Protein p53 | 1995 |
Effects of primary chemotherapy on biological parameters of locally advanced breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Cisplatin; Cyclophosphamide; Epirubicin; Evaluation Studies as Topic; Female; Fluorouracil; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Methotrexate; Middle Aged; Prospective Studies; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Receptor, IGF Type 1; Thymidine; Treatment Outcome; Tritium | 1996 |
Significant renoprotective effect of telbivudine during preemptive antiviral therapy in advanced liver cancer patients receiving cisplatin-based chemotherapy: a case-control study.
Topics: Acute Kidney Injury; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Carcinoma, Hepatocellular; Cisplatin; Female; Fluorouracil; Hepatitis B, Chronic; Humans; Kaplan-Meier Estimate; Liver Neoplasms; Male; Middle Aged; Mitomycin; Protective Agents; Telbivudine; Thymidine; Treatment Outcome | 2014 |
319 other study(ies) available for fluorouracil and thymidine
| Article | Year |
|---|---|
Synthesis and biological activities of some uronic acids, uronates, uronamides, and urononitriles of pyrimidine nucleosides.
Topics: Animals; Cell Division; Cells, Cultured; Chick Embryo; Pyrimidine Nucleosides; Sarcoma 180; Simplexvirus; Streptococcus; Structure-Activity Relationship; Substrate Specificity; Thymidine Kinase; Thymidylate Synthase; Uronic Acids; Virus Replication | 1978 |
The effects of 5-fluorouracil and 5-fluorodeoxyuridine used alone and in combination with normal nucleic acid precursors on development of mice in lines selected for low and high expression of Strong's luxoid gene.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cell Survival; Drug Synergism; Female; Fetal Death; Floxuridine; Fluorouracil; Forelimb; Genes; Hindlimb; Mice; Mutation; Nucleic Acids; Pregnancy; Protein Precursors; Thymidine; Thymine; Tibia; Toes; Uracil | 1975 |
Sensitivity tests of tumors to cytostatic agents. I. Comparative investigations on transplanted tumors in vivo and in vitro.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Cell Division; Cricetinae; Dactinomycin; Daunorubicin; Dose-Response Relationship, Drug; Doxorubicin; Fluorouracil; In Vitro Techniques; Melanoma; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Neoplasms, Experimental; Plasmacytoma; Procarbazine; Rats; Rats, Inbred ACI; Sarcoma 180; Thymidine; Triaziquone; Uridine | 1975 |
Increased urinary excretion of nucleic acid and nicotinamide derivatives by rats after treatment with alkylating agents.
Topics: 2-Acetylaminofluorene; Alkylating Agents; Animals; Benz(a)Anthracenes; Busulfan; Chromatography, Thin Layer; Cytarabine; Deoxycytidine; Dichlorvos; Dimethylnitrosamine; Ethyl Methanesulfonate; Female; Fluorouracil; Hydrocarbons, Brominated; Mechlorethamine; Methylguanidine; Niacinamide; Nitrosourea Compounds; Rats; Thymidine; Uric Acid | 1975 |
Oncogenic transformation of C3H/10T1/2 clone 8 mouse embryo cells by halogenated pyrimidine nucleosides.
Topics: Animals; Antigens, Viral; Bromodeoxyuridine; Cell Division; Cell Line; Cell Transformation, Neoplastic; Clone Cells; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Idoxuridine; Mice; Oncogenic Viruses; Sarcoma, Experimental; Thymidine; Time Factors; Trifluridine | 1976 |
Toxoplasma gondii: characterization of a mutant resistant to 5-fluorodeoxyuridine.
Topics: Animals; Cell Line; Deoxyuridine; DNA; Drug Resistance; Floxuridine; Fluorouracil; Genes; Mutation; RNA; Thymidine; Toxoplasma; Uridine | 1977 |
[Mechanism of the chromosome damaging effect of ftorafur].
Topics: Animals; Cell Line; Chromosome Aberrations; Chromosomes; Cricetinae; Floxuridine; Fluorouracil; Mitosis; Mutagens; Tegafur; Thymidine | 1977 |
Defective transport of thymidine by cultured cells resistant to 5-bromodeoxyuridine.
Topics: Biological Transport, Active; Bromodeoxyuridine; Drug Resistance; Floxuridine; Fluorouracil; HeLa Cells; Kinetics; Mutation; Ribonucleosides; Thymidine; Thymidine Kinase | 1977 |
Biochemical aspects of the interactions of the teratogens 5-fluorouracil and 5-fluorodeoxyuridine with normal nucleic acid precursors in mice selected for low and high expression of Strong's luxoid gene.
Topics: Animals; Carbon Radioisotopes; DNA; Embryo, Mammalian; Floxuridine; Fluorouracil; Mice; Mice, Mutant Strains; Nucleic Acid Precursors; RNA; Teratogens; Thymidine | 1978 |
Selectivity of action of 5-FU: biochemical basis.
Topics: Animals; Colonic Neoplasms; Drug Resistance; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Leukemia L1210; Mice; Mice, Inbred Strains; Rats; RNA, Neoplasm; Thymidine; Uridine | 1979 |
Distinguishing between membrane transport and intracellular metabolism of fluorodeoxyuridine in Ehrlich ascites tumor cells by application of kinetic and high performance liquid chromatographic techniques.
Topics: Animals; Biological Transport, Active; Carcinoma, Ehrlich Tumor; Cell Membrane; Chromatography, High Pressure Liquid; Deoxyuridine; Floxuridine; Fluorouracil; Kinetics; Mice; Thymidine; Uridine | 1979 |
Utilization of 3H from deoxyuridine and thymidine for synthesis of DNA and tother macromolecules in various organs of the rat.
Topics: Animals; Bone Marrow; Carcinoma, Hepatocellular; Deoxyuridine; DNA; Fluorouracil; Intestinal Mucosa; Liver; Liver Neoplasms; Rats; Rats, Inbred ACI; RNA; Thymidine; Tritium | 1977 |
Physiological state of human embryonic lung cells affects their response to human cytomegalovirus.
Topics: Antigens, Viral; Cell Line; Cytomegalovirus; DNA; DNA, Viral; Fluorouracil; Herpesvirus 1, Suid; Humans; Lung; Simplexvirus; Thymidine; Virus Replication | 1977 |
In vitro incorporation of [3H]TdR in human and murine solid tumours. Influence of 5-fluorouracil and/or hyperbaric oxygen on spatial distribution of labelling.
Topics: Animals; Autoradiography; Carcinoma, Squamous Cell; Fluorouracil; Humans; Mice; Neoplasms; Neoplasms, Experimental; Neoplasms, Germ Cell and Embryonal; Oxygen; Partial Pressure; Sarcoma; Thymidine; Tritium | 1979 |
In vivo enhancement of 5-fluorouracil cytotoxicity to AKR leukemia cells by thymidine in mice.
Topics: Animals; Cell Survival; Colony-Forming Units Assay; Drug Synergism; Drug Therapy, Combination; Female; Fluorouracil; Leukemia L1210; Leukemia, Experimental; Male; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred DBA; Thymidine; Time Factors | 1978 |
Nude mouse models as predictors of chemotherapy in man: thymidine and pyrimidines.
Topics: Animals; Antineoplastic Agents; Drug Evaluation, Preclinical; Drug Therapy, Combination; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasms, Experimental; Pyrimidines; Research; Thymidine; Transplantation, Heterologous | 1979 |
A method for continuous drug infusion in unrestrained rats: its application in evaluating the toxicity of 5-fluorouracil/thymidine combinations.
Topics: Animals; Drug Synergism; Female; Fluorouracil; Infusions, Parenteral; Rats; Thymidine | 1979 |
Augmentation by thymidine of the incorporation and distribution of 5-fluorouracil in ribosomal RNA.
Topics: Animals; Fluorouracil; Liver; Liver Regeneration; Male; Orotic Acid; Poly A; Rats; RNA, Ribosomal; Thymidine; Transcription, Genetic | 1979 |
Formation of dUMP-containing DNA by Brij-58 lysed CHO cells.
Topics: Animals; Cell Line; Cricetinae; Deoxyuracil Nucleotides; DNA; Female; Fluorouracil; Ovary; Surface-Active Agents; Thymidine; Uracil | 1979 |
Effect of 5-fluorouracil on RNA metabolism in Novikoff hepatoma cells.
Topics: Animals; Cell Line; Drug Resistance; Fluorouracil; Inosine; Liver Neoplasms, Experimental; Methylation; Rats; Ribonucleotides; RNA, Neoplasm; Thymidine; Thymidylate Synthase | 1979 |
In vitro sensitivity test of stomach cancer tissues by the use of metal grid method.
Topics: Antineoplastic Agents; Cytarabine; Drug Evaluation, Preclinical; Fluorouracil; Humans; In Vitro Techniques; Methotrexate; Mitomycins; Stomach Neoplasms; Thymidine | 1979 |
Rate of DNA synthesis as an indication of drug toxicity and as a guide for scheduling cancer therapy.
Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule; Drug Therapy, Combination; Fluorouracil; Lomustine; Methotrexate; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Thymidine | 1978 |
Effect of 5-fluorouracil and thymidine on the transmembrane potential and zeta potential of HeLa cells.
Topics: Cell Membrane; Fluorouracil; HeLa Cells; Membrane Potentials; Thymidine; Time Factors | 1978 |
The effect of systemic treatment with 5-fluorouracil on the epidermis of the guinea pig.
Topics: Animals; Autoradiography; Epidermal Cells; Epidermis; Fluorouracil; Guinea Pigs; Mitosis; Skin; Thymidine | 1978 |
Prevention of antitumor effect of 5-fluorouracil by hypoxanthine.
Topics: Animals; Cell Division; Cell Line; Fluorouracil; Hypoxanthines; Leukemia, Experimental; Mice; Thymidine; Time Factors | 1978 |
In vitro effects of methotrexate, 5-fluorouracil, cyclophosphamide and vincristine sulphate on the metabolism of induced mammary cancers in rats.
Topics: Animals; Cyclophosphamide; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Fluorouracil; In Vitro Techniques; Mammary Neoplasms, Experimental; Methotrexate; Neoplasm Proteins; Rats; Thymidine; Vincristine | 1978 |
The effect of systemic treatment with 5-fluorouracil on the epidermis of the guinea pig.
Topics: Animals; Autoradiography; Demecolcine; Epidermis; Fluorouracil; Guinea Pigs; Male; Metaphase; Mitosis; Thymidine; Time Factors; Tritium | 1978 |
Morphogenic effects of halogenated thymidine analogues on Drosophila. VI. Causal analysis of bromodeoxyuridine induced growth lesions.
Topics: Animals; Bromodeoxyuridine; DNA; Dose-Response Relationship, Drug; Drosophila melanogaster; Drug Administration Schedule; Fluorouracil; Growth Disorders; Larva; Phenotype; Thymidine; Wings, Animal | 1975 |
In vivo cell synchrony in the L1210 mouse leukaemia studied with 5-fluorouracil or 5-fluorouracil followed by cold thymidine infusion.
Topics: Animals; Cell Division; DNA; Female; Fluorouracil; Leukemia L1210; Mice; Mitotic Index; Neoplasm Transplantation; Thymidine | 1977 |
Kinetic aids to proper chemotherapeutic scheduling: labeled nucleoside incorporation studies in vivo.
Topics: Animals; Bone Marrow; Cell Survival; Cyclophosphamide; DNA, Neoplasm; Drug Administration Schedule; Fluorouracil; Granulocytes; Intestinal Mucosa; Kinetics; Lomustine; Male; Melanoma; Methotrexate; Mice; Neoplasms, Experimental; Pyrimidine Nucleosides; Thymidine; Uridine | 1976 |
Effect of cytostatic drugs on nucleic acid synthesis in mouse thymocytes and chick embryo cells.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chick Embryo; Cytarabine; Dactinomycin; Deoxyadenosines; Deoxyuridine; DNA; Fluorouracil; Melphalan; Methotrexate; Mice; Mice, Inbred Strains; Thymidine; Thymus Gland; Triaziquone; Tritium; Uridine; Vinblastine | 1975 |
On the character of the nuclear membrane-associated DNA of HeLa cells.
Topics: Binding Sites; Carbon Radioisotopes; Cell Fractionation; Cell Nucleus; Centrifugation, Isopycnic; Choline; Chromatography; Deoxycholic Acid; Deoxyribonucleases; DNA; DNA Repair; Fluorouracil; HeLa Cells; Humans; Membranes; Nucleic Acid Denaturation; Peptide Hydrolases; Phospholipases; Ribonucleases; Sodium Chloride; Thymidine | 1975 |
[Effect of 5-fluorouracil and irradiation of the cell kinetics of Walker carcinoma and the small intestine in rats].
Topics: Animals; Carcinoma 256, Walker; Cell Movement; Epithelial Cells; Epithelium; Fluorouracil; Intestine, Small; Mitosis; Radiation Effects; Rats; Thymidine; Time Factors; Tritium | 1975 |
The effect of cytostatic drugs on the synthesis of DNA in adenocarcinomas of the stomach. An in vitro study.
Topics: Adenocarcinoma; Antineoplastic Agents; Cells, Cultured; Depression, Chemical; DNA, Neoplasm; Fluorouracil; Humans; In Vitro Techniques; Melphalan; Methotrexate; Stomach Neoplasms; Thymidine; Tritium; Uridine; Vinblastine | 1975 |
The effect of 5-fluorouracil on the mitotic cycle and DNA synthesis in the epithelium of mouse small intestine.
Topics: Animals; DNA; Epithelial Cells; Epithelium; Fluorouracil; Intestinal Mucosa; Intestine, Small; Male; Mice; Mitosis; Thymidine | 1975 |
Comparative effects of ftorafur and 5-fluorouracil on DNA synthesis in rat small intestine.
Topics: Animals; Deoxyuridine; DNA; Fluorouracil; Furans; Intestine, Small; Male; Rats; Thymidine; Thymidylate Synthase | 1975 |
Incorporation of thymidine and iododeoxyuridine into the DNA of mouse tissues.
Topics: Animals; DNA; Female; Fluorouracil; Idoxuridine; Iodine Radioisotopes; Mice; Mice, Inbred Strains; Thymidine; Time Factors | 1975 |
Kinetic alterations induced by 5-fluorouracil in bone marrow, intestinal mucosa, and tumor.
Topics: Animals; Bone Marrow; Carcinoma, Ehrlich Tumor; Cell Division; Deoxyuridine; DNA; DNA, Neoplasm; Dose-Response Relationship, Drug; Fluorouracil; Intestinal Mucosa; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Thymidine | 1976 |
Chemosensitivity of head and neck cancer with the rapid thymidine incorporation assay and its clinical application.
Topics: Aged; Antibiotics, Antineoplastic; Antineoplastic Agents; Bleomycin; Child; Cisplatin; Colonic Neoplasms; DNA, Neoplasm; Doxorubicin; Drug Screening Assays, Antitumor; Fluorouracil; Head and Neck Neoplasms; Humans; Lymphatic Metastasis; Methotrexate; Middle Aged; Mitomycins; Peplomycin; Remission Induction; Stomach Neoplasms; Thymidine; Tritium; Tumor Cells, Cultured | 1992 |
Time dependence of DNA lesions and growth inhibition by ICI D1694, a new quinazoline antifolate thymidylate synthase inhibitor.
Topics: Cell Division; Cell Line; DNA; DNA Damage; DNA, Single-Stranded; Fluorouracil; Formyltetrahydrofolates; Methotrexate; Quinazolines; Rhodamines; Thiophenes; Thymidine; Thymidylate Synthase; Time Factors | 1992 |
Thymidine-modulated 5-fluorouracil metabolism in liver and RIF-1 tumors studied by 19F magnetic resonance spectroscopy.
Topics: Animals; Cell Line; Female; Fibrosarcoma; Fluorouracil; Liver; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C3H; Neoplasms, Radiation-Induced; Thymidine | 1992 |
Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase.
Topics: Animals; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Leucovorin; Mice; Mice, Inbred BALB C; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured; Uridine Monophosphate | 1992 |
Stimulation of 5-fluorouracil metabolic activation by interferon-alpha in human colon carcinoma cells.
Topics: Adenosine; Biotransformation; Cell Line; Colonic Neoplasms; DNA, Neoplasm; Fluorouracil; Humans; Interferon alpha-2; Interferon-alpha; Kinetics; Radioisotope Dilution Technique; Recombinant Proteins; RNA, Neoplasm; Thymidine; Tritium | 1992 |
Azidothymidine and dipyridamole as biochemical response modifiers: synergism with methotrexate and 5-fluorouracil in human colon and pancreatic carcinoma cells.
Topics: Adenocarcinoma; Cell Division; Cell Line; Cell Survival; Colonic Neoplasms; Dipyridamole; DNA Replication; Drug Screening Assays, Antitumor; Drug Synergism; Fluorouracil; Humans; Methotrexate; Pancreatic Neoplasms; Thymidine; Tumor Stem Cell Assay; Zidovudine | 1992 |
Solid tumour chemotherapy using implantable collagen-poly (HEMA) hydrogel containing 5-fluorouracil.
Topics: Animals; Collagen; Drug Implants; Female; Fibrosarcoma; Fluorouracil; Hydrogel, Polyethylene Glycol Dimethacrylate; Neoplasm Transplantation; Neoplasms, Experimental; Polyethylene Glycols; Rats; Rats, Inbred Strains; Thymidine | 1991 |
Broad-spectrum antiviral and cytocidal activity of cyclopentenylcytosine, a carbocyclic nucleoside targeted at CTP synthetase.
Topics: Adenosine; Amides; Antiviral Agents; Azauridine; Carbon-Nitrogen Ligases; Cell Division; Cytarabine; Cytidine; Deoxycytidine; Drug Synergism; Fluorouracil; HeLa Cells; Humans; Ligases; Nucleosides; Pyrazoles; Ribavirin; Ribonucleosides; Ribose; Thymidine; Tumor Cells, Cultured; Uracil; Virus Replication; Viruses | 1991 |
Comparative DNA strand breakage induced by FUra and FdUrd in human ileocecal adenocarcinoma (HCT-8) cells: relevance to cell growth inhibition.
Topics: Adenocarcinoma; Cell Division; Colonic Neoplasms; DNA; DNA Damage; Dose-Response Relationship, Drug; Drug Synergism; Floxuridine; Fluorouracil; Humans; In Vitro Techniques; Leucovorin; Thymidine; Time Factors | 1991 |
AZT: a biochemical response modifier of methotrexate and 5-fluorouracil cytotoxicity in human ovarian and pancreatic carcinoma cells.
Topics: Animals; Binding, Competitive; Cell Line; Dose-Response Relationship, Drug; Drug Synergism; Female; Fluorouracil; Humans; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Methotrexate; Ovarian Neoplasms; Pancreatic Neoplasms; Rats; Thymidine; Thymidine Kinase; Tumor Cells, Cultured; Zidovudine | 1991 |
Use of the deoxyuridine suppression test to evaluate localized folate deficiency in rat colonic epithelium.
Topics: Animals; Cells, Cultured; Colon; Deoxyuridine; DNA; Epithelium; Fluorouracil; Folic Acid; Male; Rats; Rats, Inbred Strains; Thymidine | 1991 |
Abrogation of interferon-induced resistance to interferon-activated major histocompatibility complex-unrestricted killers by treatment of a melanoma cell line with 5-fluorouracil.
Topics: Adult; Cell Line; Cytotoxicity, Immunologic; Dose-Response Relationship, Drug; Drug Resistance; Fluorouracil; Humans; Interferon Type I; Killer Cells, Natural; Kinetics; Major Histocompatibility Complex; Melanoma; Recombinant Proteins; Thymidine | 1991 |
Inhibition of rabbit ocular fibroblast proliferation by 5-fluorouracil and cytosine arabinoside.
Topics: Animals; Cell Adhesion; Cell Count; Cell Division; Cell Line; Cells, Cultured; Conjunctiva; Cytarabine; Dose-Response Relationship, Drug; Fibroblasts; Fluorouracil; Humans; Lethal Dose 50; Rabbits; Thymidine | 1991 |
Inhibition of hematopoietic colony-forming cells. Normal bone marrow extract versus transforming growth factor-beta 1.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Division; Cells, Cultured; Colony-Forming Units Assay; DNA Replication; Fluorouracil; Hematopoietic Stem Cells; Interleukin-3; Mice; Spleen; Thymidine; Transforming Growth Factor beta | 1991 |
Mechanism of interaction between interferon-gamma and antineoplastic agent on the differentiation of HL-60 promyelocytic cells.
Topics: Cell Differentiation; Cell Division; Cycloheximide; Dactinomycin; Drug Synergism; Fluorouracil; Humans; Interferon-gamma; Leukemia, Promyelocytic, Acute; Thymidine; Tumor Cells, Cultured | 1990 |
Chemosensitivity correlation between the primary tumors and simultaneous metastatic lymph nodes of patients evaluated by DNA synthesis inhibition assay.
Topics: Breast Neoplasms; Carbazilquinone; Cisplatin; Colorectal Neoplasms; DNA, Neoplasm; Doxorubicin; Drug Screening Assays, Antitumor; Esophageal Neoplasms; Fluorouracil; Humans; Jejunal Neoplasms; Mitomycin; Mitomycins; Pancreatic Neoplasms; Stomach Neoplasms; Thymidine | 1990 |
Biochemical modulation of 5-fluoropyrimidine toxicity by dehydroepiandrosterone in human colonic adenocarcinoma cells.
Topics: Adenocarcinoma; Carbon Radioisotopes; Colonic Neoplasms; Dehydroepiandrosterone; Fluorouracil; Humans; Interphase; Pyrimidines; Thymidine; Thymidine Monophosphate; Tumor Cells, Cultured; Uracil | 1990 |
Effect of 5-fluorouracil combination therapy on RNA processing in human colonic carcinoma cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Nucleolus; Cell Survival; Colonic Neoplasms; Fluorouracil; Humans; RNA Processing, Post-Transcriptional; RNA, Neoplasm; RNA, Ribosomal; Thymidine; Tumor Cells, Cultured | 1990 |
Cellular pharmacology of 5-fluorouracil in a human colon adenocarcinoma cell line selected for thymidine kinase deficiency.
Topics: Adenocarcinoma; Cell Division; Colonic Neoplasms; Cytosol; Fluorouracil; Humans; Kinetics; Thymidine; Thymidine Kinase; Thymidylate Synthase; Tumor Cells, Cultured | 1990 |
Azidothymidine inhibition of thymidine kinase and synergistic cytotoxicity with methotrexate and 5-fluorouracil in rat hepatoma and human colon cancer cells.
Topics: Animals; Cell Line; Cell Survival; Colonic Neoplasms; Drug Synergism; Fluorouracil; Humans; Kinetics; Liver Neoplasms, Experimental; Methotrexate; Rats; Thymidine; Thymidine Kinase; Tumor Cells, Cultured; Zidovudine | 1990 |
The cytotoxicity of 5-fluorouracil is due to its incorporation into RNA not its inhibition of thymidylate synthase as evidenced by the use of a mouse cell mutant deficient in thymidylate synthase.
Topics: Animals; Cell Survival; Fluorouracil; Mice; Mutation; RNA; Thymidine; Thymidylate Synthase | 1986 |
Modulation of cytotoxicity and metabolism of 5-fluorouracil in two intestine cell lines.
Topics: Cell Cycle; Cell Line; DNA; Drug Synergism; Floxuridine; Fluorouracil; Humans; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Inosine; Organophosphorus Compounds; Pentosyltransferases; Pyrimidine Phosphorylases; Ribosemonophosphates; RNA; Thymidine; Thymidylate Synthase | 1986 |
Effect of intracellular folate concentration on the modulation of 5-fluorouracil cytotoxicity by the elevation of phosphoribosylpyrophosphate in cultured human KB cells.
Topics: Adenosine; Carcinoma, Squamous Cell; Cell Survival; Fluorouracil; Folic Acid; Glucose; Humans; KB Cells; Leucovorin; Leukemia, Myeloid, Acute; Methotrexate; Nasopharyngeal Neoplasms; Pentosephosphates; Phosphoribosyl Pyrophosphate; Thymidine | 1987 |
Biochemical and pharmacologic basis for potentiation of 5-fluorouracil action by leucovorin.
Topics: Animals; Biotransformation; Cell Division; Colonic Neoplasms; DNA; Drug Synergism; Fluorouracil; Folic Acid; Humans; Leucovorin; Leukemia L1210; Mice; RNA; Stomach Neoplasms; Thymidine; Thymidylate Synthase | 1987 |
Dipyridamole potentiates the growth-inhibitory action of methotrexate and 5-fluorouracil in human keratinocytes in vitro.
Topics: Cell Division; Dipyridamole; DNA; Drug Synergism; Epidermal Cells; Fluorouracil; Humans; Infant, Newborn; Keratins; Male; Methotrexate; Thymidine | 1989 |
Palatal shelf reorientation in hamster embryos following treatment with 5-fluorouracil.
Topics: Abnormalities, Drug-Induced; Animals; Cricetinae; DNA; Embryo, Mammalian; Epithelial Cells; Female; Fluorouracil; Gestational Age; Mesocricetus; Palate; Pregnancy; Thymidine | 1989 |
Isolation of a thymidine kinase negative mutant of Nocardia lactamdurans.
Topics: DNA, Bacterial; Floxuridine; Fluorouracil; Mutation; Nocardia; Phenotype; Thymidine; Thymidine Kinase; Thymine | 1989 |
Binucleate cells in the Ehrlich ascites tumor. Autoradiographic labeling.
Topics: Animals; Autoradiography; Carcinoma, Ehrlich Tumor; Cell Nucleus; Female; Fluorouracil; Mice; Mice, Inbred Strains; Mitotic Index; Thymidine; Tritium | 1989 |
Species differences in substrate specificity of pyrimidine nucleoside phosphorylase.
Topics: Animals; Colon; Deoxyuridine; Digestive System; Digestive System Neoplasms; Fluorouracil; Humans; Liver; Mice; Pentosyltransferases; Pyrimidine Phosphorylases; Rats; Rectum; Species Specificity; Stomach; Substrate Specificity; Thymidine; Uridine | 1989 |
Evidence for acyloxymethyl esters of pyrimidine 5'-deoxyribonucleotides as extracellular sources of active 5'-deoxyribonucleotides in cultured cells.
Topics: Animals; Blood Physiological Phenomena; Cells, Cultured; Deoxyuracil Nucleotides; Deoxyuridine; DNA; Esters; Fluorodeoxyuridylate; Fluorouracil; Mice; Thymidine; Thymidine Monophosphate | 1989 |
Precursor-dependent differences in the incorporation of fluorouracil in RNA.
Topics: Animals; Cell Survival; Cells, Cultured; Floxuridine; Fluorouracil; Mice; RNA, Neoplasm; Sarcoma, Experimental; Thymidine; Uridine | 1986 |
Modulation of the effects of fluoropyrimidines on toxicity and tumor inhibition in rodents by uridine and thymidine.
Topics: Animals; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Leukemia L1210; Lung Neoplasms; Male; Mice; Rats; Rats, Inbred Strains; Sarcoma 180; Thymidine; Uridine | 1986 |
Cytotoxicity of floxuridine and 5-fluorouracil in human T-lymphoblast leukemia cells: enhancement by leucovorin.
Topics: Cell Division; Cell Line; Cell Survival; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leucovorin; Leukemia, Lymphoid; T-Lymphocytes; Thymidine | 1987 |
Effects of 5-methyltetrahydrofolate on the activity of fluoropyrimidines against human leukemia (CCRF-CEM) cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cell Line; Dose-Response Relationship, Drug; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leukemia, Lymphoid; Methionine; Tetrahydrofolates; Thymidine | 1987 |
Increased levels of DNA lesions induced by leucovorin-5-fluoropyrimidine in human colon adenocarcinoma.
Topics: Adenocarcinoma; Aphidicolin; Cell Line; Cell Survival; Colonic Neoplasms; Diterpenes; DNA; DNA Damage; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leucovorin; Pyrimidines; Thymidine | 1988 |
Catabolism of 5-fluoro-2'-deoxyuridine by isolated rat intestinal epithelial cells.
Topics: Animals; Epithelium; Floxuridine; Fluorouracil; In Vitro Techniques; Intestinal Mucosa; Kinetics; Male; Pentosyltransferases; Pyrimidine Phosphorylases; Rats; Rats, Inbred Strains; Thymidine; Uracil | 1988 |
Trifluorothymidine and 5-fluorouracil: antiproliferative activity in tissue culture.
Topics: Animals; Cell Division; Cornea; Culture Techniques; Dose-Response Relationship, Drug; Epithelial Cells; Fibroblasts; Fluorouracil; Humans; Rabbits; Sclera; Thymidine; Trifluridine | 1987 |
Comparative studies on in vitro human tumor clonogenic assay (HTCA) and in vivo nude mouse-isotope assay (NM-IA).
Topics: Animals; Antineoplastic Agents; Colony-Forming Units Assay; Cyclophosphamide; Doxorubicin; Fluorouracil; Humans; In Vitro Techniques; Mice; Mice, Inbred BALB C; Mice, Nude; Mitomycin; Mitomycins; Neoplasm Transplantation; Neoplasms; Predictive Value of Tests; Thymidine; Tumor Stem Cell Assay | 1987 |
Comparative study on nude mice isotope assay (NM-IA) and subrenal capsule assay (SRCA) sensitivity tests of anticancer agents.
Topics: Animals; Antineoplastic Agents; Cisplatin; Colony-Forming Units Assay; Cyclophosphamide; Doxorubicin; Fluorouracil; Kidney; Mice; Mice, Inbred BALB C; Mice, Nude; Mitomycin; Mitomycins; Neoplasm Transplantation; Neoplasms, Experimental; Thymidine; Tritium; Tumor Stem Cell Assay | 1987 |
Studies on 18F-labeled pyrimidines III. Biochemical investigation of 18F-labeled pyrimidines and comparison with 3H-deoxythymidine in tumor-bearing rats and mice.
Topics: Animals; Floxuridine; Fluorouracil; Iron Radioisotopes; Liver Neoplasms, Experimental; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms, Experimental; Pyrimidines; Radionuclide Imaging; Rats; Thymidine; Tissue Distribution; Tritium; Uridine | 1985 |
Comments on "The molecular basis for the differential sensitivity of B and T lymphocytes to growth inhibition by thymidine and 5-fluorouracil".
Topics: B-Lymphocytes; Fluorouracil; Growth Inhibitors; Humans; T-Lymphocytes; Thymidine | 1988 |
Effects of 5-fluorouracil on mitotic index and incorporation of 3H-thymidine into DNA in erythropoietic mouse spleens.
Topics: Animals; DNA; Erythropoiesis; Fluorouracil; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Mitosis; Mitotic Index; Spleen; Thymidine | 1987 |
Purine nucleosides as cell-specific modulators of 5-fluorouracil metabolism and cytotoxicity.
Topics: Animals; Cell Division; Cell Line; Fluorouracil; Pentosephosphates; Purine Nucleosides; Ribosemonophosphates; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 1987 |
Intratumoral injection of thymidine: enhancement of the antitumor activity and incorporation of 5-fluorouracil into tumor RNA in a murine tumor system.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Ehrlich Tumor; Dose-Response Relationship, Drug; Drug Synergism; Female; Fluorouracil; Injections, Intraperitoneal; Liver; Mice; Proteins; RNA, Neoplasm; Scintillation Counting; Thymidine; Time Factors | 1986 |
Modulation of fluorouracil metabolism and cytotoxicity by nitrothiobenzylinosine.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; Fluorouracil; Humans; Inosine; Thioinosine; Thymidine | 1986 |
Cytokinetic parameters of locally advanced human breast cancer treated with diethylstilbestrol and chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Cycle; Cyclophosphamide; Diethylstilbestrol; DNA Polymerase II; Doxorubicin; Female; Fluorouracil; Humans; Mitotic Index; Receptors, Estrogen; Thymidine | 1986 |
In vitro degradation of pyrimidine bases: studies of rat liver dihydropyrimidine dehydrogenase.
Topics: Animals; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Kinetics; Liver; Oxidoreductases; Pyrimidines; Rats; Thymidine; Thymine; Uracil; Uridine | 1986 |
Cell kinetics in selection and stratification of patients for adjuvant therapy of breast carcinoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast; Breast Neoplasms; Carcinoma in Situ; Cell Cycle; DNA, Neoplasm; Epithelium; Evaluation Studies as Topic; Female; Flow Cytometry; Fluorouracil; Humans; Melphalan; Methotrexate; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Receptors, Estrogen; Receptors, Progesterone; Thymidine; Tritium | 1986 |
Schedule-dependent antitumor and toxic effects of thymidine and 5-fluorouracil in AKR and L1210 leukemias.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Female; Fluorouracil; Hematopoietic Stem Cells; Leukemia L1210; Leukemia, Experimental; Male; Mice; Mice, Inbred Strains; Neoplastic Stem Cells; Thymidine | 1986 |
Dissociation of 5-fluorouracil-induced DNA fragmentation from either its incorporation into DNA or its cytotoxicity in murine T-lymphoma (S-49) cells.
Topics: Animals; Cell Survival; Chromatography, High Pressure Liquid; Colony-Forming Units Assay; Crotalid Venoms; Deoxyribonuclease I; DNA; Fluorouracil; Lymphoma; Mice; Thymidine; Uridine | 1987 |
Development and characterization of a human colon adenocarcinoma xenograft deficient in thymidine salvage.
Topics: Adenocarcinoma; Animals; Carcinoembryonic Antigen; Colonic Neoplasms; Fluorouracil; Humans; Isoenzymes; L-Lactate Dehydrogenase; Mice; Mucins; Neoplasm Transplantation; Thymidine; Thymidine Kinase; Transplantation, Heterologous | 1987 |
The molecular basis for the differential sensitivity of B and T lymphocytes to growth inhibition by thymidine and 5-fluorouracil.
Topics: B-Lymphocytes; Cells, Cultured; Chromatography, Gel; Chromatography, Ion Exchange; Drug Resistance; Fluorouracil; Growth Inhibitors; Humans; Leukemia; Lymphocytes, Null; Molecular Weight; T-Lymphocytes; Thymidine; Thymidine Phosphorylase | 1985 |
Selective modulation of 5-fluorouracil action in patients with colorectal carcinoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fluorouracil; Humans; Kinetics; Leucovorin; Mice; Mice, Inbred BALB C; Rats; Rectal Neoplasms; Thymidine | 1985 |
Effect of (E)-5-(2-bromovinyl)uracil on the catabolism and antitumor activity of 5-fluorouracil in rats and leukemic mice.
Topics: Animals; Bromouracil; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Fluorouracil; Leukemia P388; Leukemia, Experimental; Liver; Metabolic Clearance Rate; Mice; Oxidoreductases; Pyrimidines; Rats; Thymidine; Thymine; Uracil | 1986 |
[Biochemical modulation of 5-FU by thymidine and N-phosphoacetyl-L-aspartate: the relation between 5-FU incorporation into RNA and its cytocidal effect].
Topics: Animals; Aspartic Acid; Cell Division; Cell Survival; Cells, Cultured; DNA, Neoplasm; Drug Synergism; Female; Fluorouracil; Mammary Neoplasms, Experimental; Mice; Organophosphorus Compounds; Phosphonoacetic Acid; RNA, Neoplasm; Thymidine; Tumor Stem Cell Assay | 1986 |
Phase I evaluation and pharmacokinetic study of weekly iv thymidine and 5-FU in patients with advanced colorectal carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Fluorouracil; Half-Life; Humans; Infusions, Parenteral; Kinetics; Middle Aged; Neoplasm Metastasis; Rectal Neoplasms; Thymidine | 1985 |
Phase I-II clinical trial of thymidine, 5-FU, and PALA given in combination.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colonic Neoplasms; Drug Evaluation; Fluorouracil; Humans; Middle Aged; Phosphonoacetic Acid; Rectal Neoplasms; Thymidine | 1985 |
Fluorouracil (5-FU) and cytarabine (ara-C) inhibition of corneal epithelial cell and conjunctival fibroblast proliferation.
Topics: Animals; Cell Division; Conjunctiva; Cornea; Culture Techniques; Cytarabine; Epithelial Cells; Fibroblasts; Fluorouracil; Rabbits; Thymidine | 1985 |
Effects of uridine and thymidine on the degradation of 5-fluorouracil, uracil, and thymine by rat liver dihydropyrimidine dehydrogenase.
Topics: Animals; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Kinetics; Liver; Oxidoreductases; Rats; Rats, Inbred Strains; Thymidine; Thymine; Uracil; Uridine | 1985 |
Sequential administration of thymidine, 5-fluorouracil, and PALA. A phase I-II study.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Carcinoma, Bronchogenic; Chromatography, High Pressure Liquid; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Fluorouracil; Half-Life; Humans; Infusions, Parenteral; Middle Aged; Organophosphorus Compounds; Phosphonoacetic Acid; Stomach Neoplasms; Thymidine | 1985 |
Estrogen induced expansion of the growth fraction in receptor negative human breast cancer.
Topics: Breast Neoplasms; Cell Division; Cyclophosphamide; Diethylstilbestrol; DNA Polymerase II; DNA Replication; Doxorubicin; Drug Therapy, Combination; Estrogens; Female; Fluorouracil; Humans; Receptors, Estrogen; Thymidine | 1985 |
Effect of various anticancer agents on DNA polymerase.
Topics: Adenosine Triphosphate; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Bleomycin; Bone Marrow; Carcinoma, Hepatocellular; Cytosine Nucleotides; Dactinomycin; Deoxyribonucleotides; DNA Nucleotidyltransferases; DNA, Neoplasm; Fluorouracil; Guanosine Triphosphate; Liver; Liver Neoplasms; Liver Regeneration; Mitomycins; Neoplasms, Experimental; Rats; Rifampin; Thymidine; Tritium | 1971 |
Lead-positive nuclear structures and their behavior under the effect of various drugs.
Topics: Adenosine; Cell Line; Cell Nucleolus; Cell Nucleus; Cycloheximide; Dactinomycin; Deoxyadenosines; Female; Fluorouracil; Histological Techniques; Humans; Lead; Methods; Microscopy, Electron; Pepsin A; Puromycin; Ribonucleases; Staining and Labeling; Thymidine; Trypsin; Uterine Cervical Neoplasms | 1972 |
Inhibition of DNA polymerases and neoplastic cells by selected SH inhibitors.
Topics: Animals; Antineoplastic Agents; Arsenicals; Benzoates; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Chromatography, Thin Layer; Colonic Neoplasms; DNA Nucleotidyltransferases; DNA, Neoplasm; Dogs; Fluorouracil; Humans; In Vitro Techniques; Iodoacetates; Leukocytes; Liver; Liver Regeneration; Lung Neoplasms; Mechlorethamine; Mice; Neoplasms; Pancreatic Neoplasms; Reverse Transcriptase Inhibitors; Sulfhydryl Reagents; Thymidine; Thymine Nucleotides; Tritium | 1972 |
A dissection of the inhibitory effects of 5-fluorouracil in Bacillus cereus.
Topics: Bacillus cereus; Carbon Radioisotopes; Cell Count; Cell Division; Cell Nucleus; Cell Survival; Colorimetry; Depression, Chemical; DNA, Bacterial; Fluorouracil; Guanine; Staining and Labeling; Thymidine; Time Factors | 1973 |
Effect of anticancer chemotherapy on the lymphocyte blastoid transformation.
Topics: Adult; Aged; Animals; Bleomycin; Cyclophosphamide; Fluorouracil; Gastrointestinal Neoplasms; Humans; Lectins; Lung Neoplasms; Lymphocyte Activation; Middle Aged; Mitomycins; Neoplasms, Experimental; Rabbits; Thymidine; Tritium | 1973 |
[Selective tumour chemotherapy using oncobiograms (author's transl)].
Topics: Animals; Antineoplastic Agents; Bleomycin; Cricetinae; Culture Techniques; Cytarabine; Dactinomycin; Daunorubicin; Doxorubicin; Drug Evaluation; Drug Resistance; Fluorouracil; Humans; Methods; Methotrexate; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; Procarbazine; Radioisotopes; Rats; Scintillation Counting; Thymidine; Triaziquone; Uridine | 1974 |
[Estimation of tumor sensitivity in vitro. I. Comparative studies with the Jensen sarcoma in vivo and in vitro after 1-hour-incubation].
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Autoradiography; Cycloparaffins; Dactinomycin; DNA, Neoplasm; Fluorouracil; In Vitro Techniques; Methods; Methotrexate; Mustard Compounds; Neoplasm Transplantation; Nucleosides; Rats; RNA, Neoplasm; Sarcoma, Experimental; Thymidine; Time Factors; Triaziquone; Tritium; Uridine; Vinblastine | 1969 |
[On the question of preclinical selection of cytostatics in the area of treatment of human tumors].
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Carcinoma 256, Walker; Cricetinae; Culture Techniques; Dactinomycin; Depression, Chemical; DNA, Neoplasm; Fluorouracil; Humans; Lung Neoplasms; Methods; Methotrexate; Neoplasms; Neoplasms, Experimental; Radionuclide Imaging; Rats; RNA, Neoplasm; Stimulation, Chemical; Thymidine; Triaziquone; Tritium; Vinblastine; Vincristine | 1969 |
The roles of various biochemical effects produced by 5-fluorouracil in early growth inhibition of Bacillus cereus.
Topics: Bacillus cereus; Carbon Radioisotopes; Centrifugation, Density Gradient; Fluorouracil; Guanine; Ribosomes; RNA, Bacterial; Spectrophotometry, Ultraviolet; Thymidine; Uracil | 1974 |
Errors in DNA replication in bacteria in the presence of a thymidylic acid deficiency.
Topics: Bacillus subtilis; Bromouracil; Cell Survival; Deoxyribonucleosides; DNA Replication; Drug Resistance, Microbial; Escherichia coli; Fluorouracil; Glucose; Kinetics; Mathematics; Methyltransferases; Mutagens; Mutation; Probability; Species Specificity; Streptomycin; Thymidine; Thymidylate Synthase; Thymine; Time Factors; Tryptophan | 1974 |
Congenital malformations produced in chickens by fluorinated pyrimidines.
Topics: Abnormalities, Drug-Induced; Animals; Antimetabolites; Chick Embryo; Floxuridine; Fluorouracil; Pyrimidines; Thymidine | 1966 |
The effect of nucleic acid synthesis inhibitors on the chlorophyll formation by etiolated bean leaves.
Topics: Azaguanine; Chlorophyll; Dactinomycin; Floxuridine; Fluorouracil; In Vitro Techniques; Mitomycins; Plants, Edible; Thiouracil; Thymidine; Uridine | 1966 |
The response in vitro, of continuous cultures of human lymphoblasts (CCRF-CEM cells) to chemotherapeutic agents.
Topics: Animals; Azaserine; Chloramphenicol; Culture Media; Culture Techniques; Cyclophosphamide; Cytarabine; Dactinomycin; Deoxyuridine; Floxuridine; Fluorouracil; Humans; Hydrocortisone; Lymphocytes; Mechlorethamine; Mercaptopurine; Methotrexate; Mitomycins; Puromycin; Thymidine; Triazines; Vincristine | 1967 |
Determinants of human tumor sensitivity to fluorinated pyrimidine chemotherapy.
Topics: DNA, Neoplasm; Floxuridine; Fluorouracil; Humans; In Vitro Techniques; Ligases; Neoplasm Metastasis; Neoplasms; Phosphotransferases; Thymidine; Thymidine Kinase; Uracil Nucleotides; Uridine | 1967 |
Radiosensitization of brain tumor cells with a thymidine analogue (bromouridine).
Topics: Astrocytoma; Brain Neoplasms; Bromodeoxyuridine; Culture Techniques; DNA; Floxuridine; Fluorouracil; Follow-Up Studies; Glioma; Humans; Meningioma; Methotrexate; Oligodendroglioma; Radiation-Sensitizing Agents; Thymidine | 1968 |
[Comparative in vitro studies with 5-fluorouracil and some of its derivatives].
Topics: Acyltransferases; Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cell-Free System; Depression, Chemical; DNA Nucleotidyltransferases; DNA, Neoplasm; Floxuridine; Fluorine; Fluorouracil; In Vitro Techniques; Leucine; Neoplasm Proteins; Nucleotides; RNA, Neoplasm; Thymidine; Uridine | 1969 |
[Effects of cytostatics and x-rays on nucleic acid metabolism of solid, malignant tumors in vitro].
Topics: Adenine; Animals; Antineoplastic Agents; Carbon Isotopes; Dactinomycin; Depression, Chemical; DNA, Neoplasm; Estriol; Fluorouracil; Formates; Glycine; Hypoxanthines; In Vitro Techniques; Leucine; Mercaptopurine; Methotrexate; Methylprednisolone; Neoplasm Proteins; Neoplasms, Experimental; Nucleosides; Orotic Acid; Radiation Effects; RNA, Neoplasm; Testosterone; Thymidine; Triaziquone; Uracil; Uridine | 1970 |
Metabolism of pyrimidines and pyrimidine nucleosides by Salmonella typhimurium.
Topics: Aminohydrolases; Cytidine; Cytosine; Deoxyuridine; Floxuridine; Flucytosine; Fluorouracil; Genetics, Microbial; Genotype; Mutation; Nucleosides; Nucleotidyltransferases; Pentosyltransferases; Phosphotransferases; Pyrimidines; Salmonella typhimurium; Thymidine; Uracil; Uracil Nucleotides; Uridine | 1972 |
Incorporation of thymidine after administration of fluorouracil and fluorouridine to adult and embryo mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cleft Palate; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; Fetus; Floxuridine; Fluorine; Fluorouracil; Mice; Mice, Inbred Strains; Pregnancy; Rats; Thymidine; Time Factors; Tritium; Uridine | 1971 |
Incorporation of idoxuridine analogs into corneal herpes simplex virus.
Topics: Animals; Autoradiography; Bromodeoxyuridine; Cornea; DNA, Viral; Epithelium; Floxuridine; Fluorouracil; Herpes Simplex; Idoxuridine; Keratitis, Dendritic; Ophthalmic Solutions; Rabbits; Thymidine; Tritium; Uracil | 1972 |
R factor elimination by inhibitors of thymidylate synthetase (fluorodeoxyuridine and showdomycin) and the occurrence of single strand breaks in plasmid DNA.
Topics: Antibiotics, Antineoplastic; DNA, Bacterial; Drug Resistance, Microbial; Escherichia coli; Extrachromosomal Inheritance; Floxuridine; Fluorouracil; Genetics, Microbial; Methyltransferases; Molecular Biology; Nucleosides; Thymidine; Uracil Nucleotides | 1974 |
Effect of 5-fluorouracil on the multiplication of a virulent virus (pseudorabies) and an oncogenic virus (polyoma).
Topics: Autoradiography; Carbon Isotopes; Chromatography; Culture Techniques; DNA; DNA, Viral; Fluorescent Antibody Technique; Fluorouracil; Herpesviridae; Polyomavirus; Thymidine; Tritium | 1967 |
Productive and abortive infections of simian and nonsimian cells with a simian adenovirus SV15. II. Viral biosynthesis and effects of chemical inhibitors.
Topics: Adenoviridae; Animals; Antigens; Antimetabolites; Complement Fixation Tests; Cricetinae; Culture Techniques; Cycloheximide; Cytarabine; Cytopathogenic Effect, Viral; Dactinomycin; Defective Viruses; DNA, Viral; Fluorescent Antibody Technique; Fluorouracil; Haplorhini; Helper Viruses; Immunodiffusion; Phenylalanine; Polyomavirus; Thymidine; Tritium; Viral Proteins; Virus Replication | 1968 |
Neurologic surgery.
Topics: Animals; Brain Neoplasms; Cats; Dogs; Fluorouracil; Glioblastoma; Humans; Hypothermia, Induced; Laminectomy; Neurosurgery; Spinal Cord Injuries; Thymidine; Warfarin | 1970 |
Cellular DNA synthesis in productive infection with adenoviruses.
Topics: Adenoviridae; Adenoviridae Infections; Animals; Cricetinae; Culture Techniques; DNA; DNA, Viral; Embryo, Mammalian; Fluorouracil; Humans; Hybridization, Genetic; Kidney; Lung; Thymidine; Tritium; Virus Cultivation; Virus Replication | 1970 |
Effect of various inhibitors on the expression of polyoma virus-induced surface antigen in BHK21 cells.
Topics: Amino Acids; Animals; Antigens, Viral; Autoradiography; Bromodeoxyuridine; Carbon Radioisotopes; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Cycloheximide; Cytarabine; DNA, Viral; Fluorescent Antibody Technique; Fluorouracil; Kidney; Microscopy, Fluorescence; Mitomycins; Polyomavirus; Puromycin; RNA, Viral; Thymidine; Time Factors; Tritium; Viral Proteins | 1973 |
In vitro-in vivo studies on the susceptibility of the solid Yoshida sarcoma to drugs and hyperthermia (42 degrees).
Topics: Animals; Antineoplastic Agents; Carbon Dioxide; Carbon Radioisotopes; Cell Survival; Cells, Cultured; Cyclophosphamide; Dactinomycin; Fluorouracil; Glycolysis; Hot Temperature; Leucine; Mesylates; Oxygen Consumption; Rats; Sarcoma, Yoshida; Thymidine; Time Factors; Uridine; Vinblastine | 1974 |
The deoxyribonucleoside transport systems of cultured Novikoff rat hepatoma cells.
Topics: Animals; Biological Transport; Carcinoma, Hepatocellular; Cell Line; Cell Membrane Permeability; Cells, Cultured; Cytochalasin B; Deoxyribonucleosides; Deoxyuridine; Depression, Chemical; Dipyridamole; Fluorouracil; Kinetics; Liver Neoplasms; Neoplasms, Experimental; Rats; Thymidine; Time Factors; Tritium | 1974 |
Incorporation of precursors and inhibitors of nucleic acid synthesis into hepatomas and liver of the rat.
Topics: Amino Acids; Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Line; Fluorouracil; Injections, Intraperitoneal; Injections, Subcutaneous; Liver; Liver Neoplasms; Liver Regeneration; Male; Neoplasm Transplantation; Neoplasms, Experimental; Orotic Acid; Phosphates; Rats; RNA, Neoplasm; Schistosomicides; Thioxanthenes; Thymidine; Time Factors; Transplantation, Homologous; Tritium; Uracil; Uridine | 1974 |
Nucleic acid and protein synthesis and pattern regulation in hydra. II. Effect of inhibition of nucleic acid and protein synthesis on hypostome formation.
Topics: Animals; Chloramphenicol; Cnidaria; Cytosine; Dactinomycin; DNA; Fluorouracil; Hydroxyurea; Morphogenesis; Protein Biosynthesis; RNA; RNA, Messenger; Thymidine; Transplantation; Tritium; Uridine | 1969 |
Inhibitory effects and metabolism of 5-fluoropyrimidine derivatives in pneumococcus.
Topics: Aluminum; Autoradiography; Bacterial Proteins; Bacteriological Techniques; Carbon Isotopes; Cell-Free System; Chemical Precipitation; Chromatography, Ion Exchange; Chromatography, Thin Layer; Colorimetry; Culture Media; Cytosine; DNA, Bacterial; Filtration; Floxuridine; Fluorouracil; Freezing; Microscopy, Phase-Contrast; Nucleotidyltransferases; Oxides; Pyrimidinones; RNA, Bacterial; Streptococcus pneumoniae; Thymidine; Trichloroacetic Acid | 1971 |
The effect of pre-inhibition of DNA synthesis in continuous human amniotic cell culture (strain FL) on adenovirus type 5 reproduction.
Topics: Adenoviridae; Aminopterin; Amnion; Animals; Antigens; Autoradiography; Cell Line; Cell Nucleus; Cells, Cultured; DNA; Floxuridine; Fluorescent Antibody Technique; Fluorouracil; Humans; Immune Sera; Rabbits; Radiation Effects; Thymidine; Time Factors; Tritium; Ultraviolet Rays; Virus Replication | 1969 |
The effect of heparin on the cytotoxicity and uptake of anti-neoplastic drugs in cultured Burkitt lymphoma cells.
Topics: Burkitt Lymphoma; Cell Division; Cell Survival; Cells, Cultured; DNA, Neoplasm; Fluorouracil; Heparin; Humans; Mechlorethamine; Mercaptopurine; Methotrexate; Thymidine; Time Factors; Tritium | 1974 |
In vitro estimate of sensitivity of individual human tumors to antitumor agents.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Arsenicals; Benzoates; Breast Neoplasms; Carbon Radioisotopes; Carcinoma; Carcinoma, Ehrlich Tumor; Cattle; Depression, Chemical; DNA, Neoplasm; Female; Fluorouracil; Humans; In Vitro Techniques; Iodoacetates; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Lymphoma, Non-Hodgkin; Mechlorethamine; Methotrexate; Mice; Neoplasms; Phenylalanine; Succinate Dehydrogenase; Thymidine; Tritium | 1974 |
An anomalous effect of hydroxyurea and visible light on nucleic acids of a photoreactivating mammalian cell Potorous tridactylis.
Topics: Animals; Carbon Isotopes; Cells, Cultured; Deoxyribonucleosides; Depression, Chemical; DNA; Fluorouracil; Hydroxyurea; In Vitro Techniques; L Cells; Light; Marsupialia; Radiation Effects; Radiobiology; RNA; Thymidine; Tritium; Uridine | 1972 |
Changes in the deoxyribonucleoside triphosphate pools of mouse 5178Y lymphoma cells following exposure to methotrexate or 5-fluorouracil.
Topics: Adenosine Triphosphate; Animals; Cell Line; Cells, Cultured; Deoxyadenosines; Deoxycytidine; Deoxyribonucleotides; Deoxyuridine; DNA, Neoplasm; Fluorouracil; Guanosine; Leukemia, Experimental; Leukemia, Lymphoid; Methotrexate; Mice; Phosphates; Thymidine; Tritium | 1973 |
Degree of participation of exogenous thymidine in the overall deoxyribonucleic acid synthesis in Escherichia coli.
Topics: Amino Acids; Culture Media; Deoxyribonucleotides; DNA, Bacterial; Escherichia coli; Fluorouracil; Genetics, Microbial; Mutation; Pentosyltransferases; Temperature; Thymidine; Tritium | 1972 |
Genetic and physiological factors relating to excision-repair in Escherichia coli.
Topics: Cell Survival; Coliphages; Deoxyribonucleases; DNA Nucleotidyltransferases; DNA Repair; DNA, Bacterial; DNA, Viral; Escherichia coli; Fluorouracil; Molecular Weight; Mutation; Nucleic Acid Denaturation; Pyrimidines; Radiation Effects; Thymidine; Thymine; Time Factors; Tritium; Ultraviolet Rays | 1972 |
Regulation of early mRNA synthesis in bacteriophage T4-infected bacteria: dependence on bacteriophage-specific protein synthesis.
Topics: Carbon Isotopes; Chloramphenicol; Chromatography, Thin Layer; Coliphages; DNA Viruses; DNA, Viral; Escherichia coli; Fluorouracil; Mutation; Ribonucleotides; RNA, Messenger; Temperature; Thymidine; Time Factors; Transcription, Genetic; Tritium; Uracil; Viral Proteins | 1973 |
Does 5-fluorouracil cause catabolite repression?
Topics: Enzyme Induction; Enzyme Repression; Escherichia coli; Fluorouracil; Galactosidases; Genetics, Microbial; Glucose; Kinetics; Lyases; Mutation; Spectrophotometry, Ultraviolet; Thymidine; Tryptophanase | 1973 |
Morphogenic effects of halogenated thymidine analogs on Drosophila. II. Incorporation of 5 -bromodeoxyuridine into DNA.
Topics: Autoradiography; Bromodeoxyuridine; Cell Nucleus; Centrifugation, Density Gradient; Densitometry; DNA; Drosophila melanogaster; Drug Interactions; Fluorouracil; Germ Cells; Larva; Thymidine; Tritium; Ultracentrifugation | 1972 |
Incubation of surviving sections of ovarian tumours as a method of testing their sensitivity to cytostatics.
Topics: Culture Techniques; DNA, Neoplasm; Female; Fluorouracil; Humans; Melphalan; Nitrogen Mustard Compounds; Ovarian Neoplasms; Parathion; Thiotepa; Thymidine; Tritium | 1972 |
Effects of 60 Co gamma radiation on the distribution, catabolism and incorporation of 125 I-5-iodo-2'-deoxyuridine into intestinal and splenic deoxyribonucleic acid in mice.
Topics: Animals; Ascitic Fluid; Chromatography, Thin Layer; Cobalt Isotopes; DNA; DNA Replication; Fluorouracil; Idoxuridine; Intestine, Small; Iodine Isotopes; Male; Mice; Radiation Effects; Spleen; Thymidine | 1972 |
DNA synthesis outside the replication phase. Report II. An autoradiographic study of H3-thymidine incorporation into the nuclei of PHA-stimulated human lymphocytes during the G1 period.
Topics: Autoradiography; Cell Nucleus; Chromosome Aberrations; Colchicine; DNA; DNA Replication; Fluorouracil; Genotype; Humans; In Vitro Techniques; Lectins; Lymphocyte Activation; Lymphocytes; Mitosis; Thymidine; Tritium | 1972 |
Determination of therapeutic index of drugs by in vitro sensitivity tests using human host and tumor cell suspensions.
Topics: Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Deoxyuridine; DNA, Neoplasm; Fluorouracil; Humans; In Vitro Techniques; Methotrexate; Neoplasms; Penicillamine; Thymidine; Time Factors; Tritium | 1973 |
The role of thymidylate synthetase inhibitors in bromodeoxyuridine-induced neoplasia in Drosophila.
Topics: Animals; Bromodeoxyuridine; Centrifugation, Density Gradient; DNA; Drosophila; Fluorine; Fluorouracil; Idoxuridine; Larva; Methotrexate; Methyltransferases; Neoplasms, Experimental; Thymidine; Thymidylate Synthase; Tritium | 1973 |
Age cohort variation of tumor cells.
Topics: Animals; Cell Division; Disease Models, Animal; DNA, Neoplasm; Fluorouracil; Hydroxyurea; Lymphoma; Mice; Mitosis; Models, Biological; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; RNA, Neoplasm; Thymidine; Time Factors; Tritium | 1973 |
DNA synthesis outside the replication phase. Report I. Cytogenetic analysis of the action of DNA-synthesis inhibitors on human lymphocytes in vitro as it relates to the functional state of the genome.
Topics: Autoradiography; Cell Division; Chromosome Aberrations; Dactinomycin; DNA; DNA Replication; Drug Interactions; Fluorouracil; Genotype; Humans; In Vitro Techniques; Lectins; Lymphocytes; Thymidine; Transcription, Genetic; Tritium; Uracil Mustard | 1974 |
Synchronization of human tissues and its consequences for cancer therapy in ENT. Cell kinetic and clinical studies.
Topics: Aged; Animals; Carcinoma; Carcinoma, Squamous Cell; Cell Division; DNA Replication; DNA, Neoplasm; Ear Neoplasms; Female; Fluorouracil; Humans; Lymphatic Metastasis; Male; Mice; Middle Aged; Mitosis; Nasopharyngeal Neoplasms; Neoplasms, Experimental; Skin Neoplasms; Thymidine; Tritium | 1974 |
Repair replication induced by 3H incorporated into HeLa DNA.
Topics: Bromouracil; Centrifugation, Density Gradient; Culture Media; DNA Repair; DNA Replication; DNA, Neoplasm; Fluorouracil; HeLa Cells; Humans; In Vitro Techniques; Iodine Radioisotopes; Thymidine; Tritium; Uracil | 1974 |
Inhibition by 6-aminothymine of the degradation of nucleosides (5-iododeoxyuridine, thymidine) and pyrimidine bases (5-iodouracil, uracil and 5-fluorouracil) in vivo.
Topics: Amines; Animals; Antimetabolites; Bone Marrow; Chromatography; DNA; Fluorouracil; Idoxuridine; Intestinal Mucosa; Iodine Radioisotopes; Male; Mice; Nucleosides; Pentosyltransferases; Rabbits; Spleen; Thymidine; Thymine; Thymus Gland; Uracil | 1974 |
The effects of cytostatic drugs on transplanted tumours. An investigation of the correlation between in vivo and in vitro results.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Cricetinae; Cytarabine; Daunorubicin; Fluorouracil; Melanoma; Methotrexate; Mice; Neoplasm Transplantation; Plasmacytoma; Procarbazine; Rats; Thymidine; Tritium; Uridine | 1974 |
Androgen-induced sexual differentiation of the brain is blocked by inhibitors of DNA and RNA synthesis.
Topics: Animals; Animals, Newborn; Brain; Dactinomycin; Depression, Chemical; DNA; Estrus; Female; Fluorouracil; Gonadotropins; Hydroxyurea; Hypothalamus; Mycotoxins; Organ Size; Ovary; Ovulation; Pregnancy; Protein Biosynthesis; Puromycin; Rats; RNA; Sex Factors; Testosterone; Thymidine; Tritium | 1974 |
Regulation of early RNA synthesis in bacteriophage T4-infected Escherichia coli cells.
Topics: Carbon Isotopes; Coliphages; Escherichia coli; Fluorouracil; Kinetics; Leucine; Mutation; RNA, Messenger; RNA, Viral; Temperature; Thymidine; Tritium; Uridine | 1970 |
Role of pyridine nucleotides in 5-fluorouracil-mediated reactivation of ultraviolet radiation damage.
Topics: Centrifugation, Density Gradient; Coliphages; Escherichia coli; Fluorouracil; Nucleotides; Oxygen Consumption; Pyridines; Radiation Effects; Spectrophotometry; Sucrose; Thymidine; Tritium; Ultraviolet Rays | 1971 |
Properties of the DNA-delay mutants of bacteriophage T4.
Topics: Aniline Compounds; Carbon Isotopes; Centrifugation, Density Gradient; Cesium; Chlorides; Coliphages; DNA Replication; DNA, Bacterial; DNA, Viral; Escherichia coli; Fluorouracil; Genes, Recessive; Genetic Complementation Test; Genetics, Microbial; Leucine; Muramidase; Mutation; Nitrogen Isotopes; RNA, Messenger; Thymidine; Time Factors; Tritium; Uracil; Viral Proteins; Virus Replication | 1971 |
Dissociation of cellular functions in Bacillus cereus by 5-fluorouracil.
Topics: Adenine; Amino Acids; Bacillus cereus; Bacterial Proteins; Carbon Isotopes; Cell Wall; DNA, Bacterial; Fluorouracil; In Vitro Techniques; Penicillinase; RNA, Bacterial; Thymidine; Tritium; Uracil | 1966 |
Comparative effects of 5-fluorouracil on strains of Bacillus megaterium.
Topics: Bacillus megaterium; Bacterial Proteins; Bacteriolysis; DNA, Bacterial; Drug Resistance, Microbial; Fluorouracil; RNA, Bacterial; Thymidine; Uridine | 1964 |
Synthesis and biological activity of dinucleoside phosphates containing 5-fluorouracil residues.
Topics: Cell Membrane Permeability; Chemistry, Organic; Chromatography, Paper; Electrophoresis; Enterococcus faecalis; Fluorouracil; Organic Chemistry Phenomena; Spectrophotometry; Thymidine; Uridine | 1966 |
Properties of 5-fluorouracil-containing ribonucleic acid and ribosomes from Bacillus subtilis.
Topics: Amino Acids; Bacillus subtilis; Centrifugation, Density Gradient; Chromatography; Fluorouracil; Molecular Biology; Nucleic Acid Denaturation; Phosphates; Phosphorus Isotopes; Ribosomes; RNA, Bacterial; Thymidine; Tritium | 1968 |
5-mercaptodeoxyuridine--its enzymatic synthesis and mode of action in microbiological systems.
Topics: Biological Assay; Cell-Free System; Chromatography, Ion Exchange; Drug Synergism; Enterococcus faecalis; Fluorouracil; Lactobacillus; Spectrum Analysis; Thymidine; Transferases; Ultraviolet Rays; Uridine | 1969 |
Requirement of cellular synthesis for Kilham rat virus replication.
Topics: Animals; Autoradiography; Culture Techniques; DNA; Fluorescent Antibody Technique; Fluorouracil; Herpesviridae; Leucine; Radiation Effects; Rats; Species Specificity; Thymidine; Tritium; Ultraviolet Rays; Uridine; Virus Cultivation; Virus Replication; Viruses, Unclassified | 1970 |
[Effect of thiophosphamide and 5-fluorouracil on the incorporation of H 3-thymidine into DNA of surviving ovarian cancer sections].
Topics: Culture Techniques; Depression, Chemical; DNA, Neoplasm; Female; Fluorouracil; Humans; Ovarian Neoplasms; Temperature; Thiotepa; Thymidine; Time Factors; Tritium | 1971 |
Morphogenic effects of halogenated thymidine analogs on Drosophila. 3. 5-Iododeoxyuridine.
Topics: Abnormalities, Drug-Induced; Animals; Centrifugation, Density Gradient; Deoxyuridine; DNA; Drosophila; Fluorouracil; Larva; Thymidine; Tritium | 1972 |
Endotoxin-induced sensitivity of hematopoietic stem cells to chemotherapeutic agents.
Topics: Animals; Biological Assay; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Cesium Isotopes; Culture Media; Cyclophosphamide; Cytarabine; Dactinomycin; Depression, Chemical; Endotoxins; Female; Fluorouracil; Hematopoietic Stem Cells; Mice; Radiation Effects; Spleen; Stimulation, Chemical; Thymidine; Tritium; Vinblastine | 1972 |
Role of catabolism in pyrimidine utilization for nucleic acid synthesis in vivo.
Topics: Animals; Azo Compounds; Dactinomycin; Depression, Chemical; DNA; DNA, Neoplasm; Fluorouracil; Intestine, Small; Iodine Isotopes; Leukemia, Experimental; Liver; Male; Nucleosides; Oxidoreductases; Pyrimidines; Rats; RNA; RNA, Neoplasm; Spleen; Thymidine; Thymine; Tritium; Uracil | 1972 |
Response of DNA thymine synthesis in human tumor and normal tissue to 5-fluorouracil.
Topics: Breast Neoplasms; Carbon Isotopes; Chromatography, Paper; Colon; Colonic Neoplasms; Depression, Chemical; DNA; DNA, Neoplasm; Female; Fluorouracil; Formates; Humans; In Vitro Techniques; Lung Neoplasms; Methyltransferases; Ovarian Neoplasms; Serine; Thymidine; Thymine; Thymine Nucleotides; Tritium; Uracil Nucleotides | 1972 |
Inhibition of cell dcivision and denervation hypersensitivity in skeletal muscle.
Topics: Acetylcholine; Animals; Fluorouracil; Hindlimb; Methotrexate; Mitosis; Muscle Contraction; Muscle Denervation; Muscles; Rats; Receptors, Drug; Thymidine; Tritium; Vincristine | 1972 |
Cytotoxic penetration and concentration in human malignant tumours.
Topics: Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Female; Fluorouracil; Humans; Injections, Intra-Arterial; Intestinal Neoplasms; Kidney Neoplasms; Neoplasms; Rectal Neoplasms; Thymidine; Tritium | 1969 |
[The modification of the cell division rhythm in human tumors].
Topics: Adult; Aged; Autoradiography; Biopsy; Cell Division; Depression, Chemical; DNA, Neoplasm; Ear Neoplasms; Female; Fluorouracil; Humans; Male; Mandibular Neoplasms; Maxillary Neoplasms; Middle Aged; Neoplasms; Thymidine; Tongue Neoplasms; Tonsillar Neoplasms; Tritium | 1969 |
The effect of 5-fluorouracil on DNA-thymine synthesis in human tumors.
Topics: Carbon Isotopes; DNA, Neoplasm; Fluorouracil; Formates; Humans; Neoplasms; Thymidine; Thymine; Tritium | 1969 |
A new paper chromatography solvent system resolving pyrimidine-pyrimidine riboside-pyrimidine deoxyriboside mixtures.
Topics: Adenine Nucleotides; Animals; Carcinoma, Ehrlich Tumor; Chromatography, Paper; Culture Techniques; Cytosine Nucleotides; DNA; Fluorouracil; Guanine Nucleotides; Methods; Nucleosides; Pyrimidines; Solvents; Spectrophotometry; Thymidine; Thymine; Ultraviolet Rays; Uracil Nucleotides | 1969 |
Metabolism of uracil and 5-fluorouracil in P388 murine leukemia cells.
Topics: Animals; Carbon Isotopes; Cell Line; Cell-Free System; Culture Techniques; Fluorouracil; Leukemia, Experimental; Nucleosides; Nucleotides; Phosphotransferases; Pyrimidines; RNA; Thymidine; Transferases; Uracil; Uridine | 1969 |
[Disturbances of development and differentiation induced in the amphibian embryo by 5-fluorouracil. (Histological and histoautoradiographic examinations)].
Topics: Abnormalities, Drug-Induced; Amphibians; Animals; Anura; Autoradiography; Brain; Cell Nucleus; DNA; Eye; Fluorouracil; Germ Layers; Karyometry; Larva; Spinal Cord; Thymidine; Tritium | 1970 |
Potential anticancer agents. VI. 5-Substituted pyrimidine-6-carboxaldehydes.
Topics: Aldehydes; Animals; Antineoplastic Agents; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Chemical Phenomena; Chemistry; DNA, Neoplasm; Fluorouracil; Formates; Mice; Orotic Acid; Phenylalanine; Protein Biosynthesis; Pyrimidines; RNA, Neoplasm; Thymidine; Tritium | 1970 |
The relation of thymidine labeling index in human tumors in vitro to the effectiveness of 5-fluorouracil chemotherapy.
Topics: Autoradiography; Fluorouracil; Humans; In Vitro Techniques; Methods; Neoplasms; Thymidine; Tritium | 1971 |
[Indication for antineoplastic agents (using 3H-thymidine)].
Topics: Antineoplastic Agents; Culture Techniques; Depression, Chemical; DNA, Neoplasm; Fluorouracil; Humans; Methotrexate; Mitomycins; Stomach Neoplasms; Thymidine; Tritium; Vinblastine | 1971 |
[On the biochemical causes of the cytostatic effect of glyceraldehyde].
Topics: Adenine Nucleotides; Animals; Antineoplastic Agents; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cell-Free System; Fluorouracil; Glyceraldehyde; Glycine; Histocytochemistry; Mice; Nucleic Acids; Phenylalanine; Phosphates; Phospholipids; Phosphorus Isotopes; Protein Biosynthesis; Ribosomes; RNA, Messenger; Thymidine; Tritium; Uracil Nucleotides | 1967 |
Studies on the mechanism of action of progesterone in regulation of the synthesis of specific protein.
Topics: Amino Acids; Animals; Chickens; Colchicine; Culture Techniques; Cycloheximide; Dactinomycin; Diethylstilbestrol; Estrogens; Female; Fluorouracil; Hydroxyurea; Mitosis; Muramidase; Ovalbumin; Oviducts; Progesterone; Protein Biosynthesis; RNA; RNA Nucleotidyltransferases; Thymidine; Tritium; Uridine | 1968 |
Fluorinated pyrimidine aldehydes. Inhibition of nucleic acid and protein biosynthesis in Ehrlich ascites carcinoma cells in vitro.
Topics: Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Chromatography, Ion Exchange; Chromatography, Thin Layer; DNA; Female; Fluorine; Fluorouracil; Formates; Glycine; In Vitro Techniques; Mice; Orotic Acid; Phenylalanine; Protein Biosynthesis; Purines; Pyrimidines; RNA; Thymidine; Tritium | 1968 |
On the mechanism of the lethal action of 5-fluorouracil on mouse L cells.
Topics: Dialysis; Fibroblasts; Fluorouracil; In Vitro Techniques; L Cells; Thymidine; Time Factors; Uridine | 1968 |
Transplacental passage of nucleotides, nucleosides, and bases.
Topics: Alkalies; Animals; Carbon Isotopes; Colchicine; Female; Fetus; Fluorouracil; Injections, Intraperitoneal; Injections, Intravenous; Liver; Maternal-Fetal Exchange; Nucleosides; Nucleotides; Orotic Acid; Placenta; Pregnancy; Purines; Pyrimidines; Radiometry; Rats; RNA; Solubility; Thymidine; Time Factors; Uracil Nucleotides; Uridine | 1968 |
[5'-desoxy-5'-fluorothymidine, a new inhibitor of the DNA synthesis].
Topics: Animals; Carcinoma, Ehrlich Tumor; Colorimetry; Depression, Chemical; DNA, Neoplasm; Fluorouracil; Mercaptopurine; Phosphates; Phosphorus Isotopes; RNA, Neoplasm; Spectrum Analysis; Thymidine; Triazines; Tritium; Uracil | 1968 |
Initiation and suppression of apical hairs of Fucus embryos Fucus embryos.
Topics: Cell Differentiation; Eukaryota; Fluorouracil; Hair; In Vitro Techniques; Thymidine; Time Factors; Uracil | 1969 |
Mechanism of pyrimethamine-induced megaloblastosis in human bone marrow.
Topics: Anemia, Macrocytic; Bone Marrow; Bone Marrow Diseases; Chorioretinitis; Culture Techniques; Deoxyuridine; DNA; Erythrocytes; Female; Fluorouracil; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Middle Aged; Nucleotides; Oxidation-Reduction; Pyrimethamine; Thymidine; Tritium | 1969 |
Relation of thymidine index to pulmonary tumor response in mice receiving urethan and other carcinogens.
Topics: Animals; Autoradiography; Carbamates; Carcinogens; Cytarabine; Dactinomycin; DNA; Fluorouracil; Injections, Intraperitoneal; Injections, Subcutaneous; Lung; Lung Neoplasms; Male; Mechlorethamine; Methylcholanthrene; Mice; Neoplasms, Experimental; Puromycin; Thymidine; Tritium; Urethane | 1969 |
Influence of antiblastic agents applied either in vivo or in vitro on human lymphocyte transformation in cell culture.
Topics: Antineoplastic Agents; Autoradiography; Colchicine; Culture Techniques; Cyclophosphamide; Daunorubicin; Fluorouracil; Humans; Hydrazines; Lectins; Lymphocyte Activation; Lymphocytes; Mechlorethamine; Prednisolone; Radiation Effects; Thymidine; Tritium; Uridine; Vinblastine | 1969 |
Potentiation of the teratogenic effects of 5-fluorouracil by natural pyrimidines. I. Biological aspects.
Topics: Abnormalities, Drug-Induced; Animals; Carbon Isotopes; Carbon Tetrachloride Poisoning; Drug Synergism; Embryo, Mammalian; Female; Fluorouracil; Injections, Intraperitoneal; Kidney; Liver; Male; Maternal-Fetal Exchange; Pregnancy; Pyrimidines; Rats; Thymidine; Thymine; Uracil; Uridine | 1969 |
Potentiation of the teratogenic effects of 5-fluorouracil by natural pyrimidines. II. Biochemical aspects.
Topics: Animals; Carbon Isotopes; Depression, Chemical; DNA; Drug Synergism; Embryo, Mammalian; Extraembryonic Membranes; Female; Fluorouracil; Formates; Injections, Intraperitoneal; Ligases; Liver; Male; Phosphorus; Phosphorus Isotopes; Pregnancy; Rats; Thymidine; Thymidine Kinase; Thymine; Uracil | 1969 |
Mechanism of growth inhibition by 5-fluorouracil. Reversal studies with pyrimidine metabolites in vitro.
Topics: Animals; Carcinoma, Ehrlich Tumor; Culture Techniques; Depression, Chemical; DNA, Neoplasm; Fluorouracil; Mice; Nucleotides; Orotic Acid; RNA, Neoplasm; Thymidine; Uridine | 1969 |
Control of certain aspects of the infective process by progeny viral DNA.
Topics: Animals; Bromodeoxyuridine; DNA; DNA, Viral; Enzymes; Fluorouracil; Herpesviridae; In Vitro Techniques; Kidney; Protein Biosynthesis; Puromycin; Rabbits; Thymidine; Virus Cultivation | 1965 |
The synergistic anti-neoplastic activity of combinations of mitomycins with either 6-thioguanine or 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; DNA, Neoplasm; Drug Synergism; Female; Fluorouracil; In Vitro Techniques; Leukemia L1210; Lysine; Male; Mice; Mitomycins; Mortality; Neoplasm Proteins; Neoplasm Transplantation; Orotic Acid; RNA, Neoplasm; Sarcoma 180; Thioguanine; Thymidine; Thymidine Kinase | 1965 |
Kinetics of proliferation of cancer cells in neoplastic effusions in man.
Topics: Adenocarcinoma; Antineoplastic Agents; Autoradiography; Cell Division; DNA, Neoplasm; Exudates and Transudates; Female; Fluorouracil; Humans; Lymphoma; Middle Aged; Neoplasm Metastasis; Neoplasms; Ovarian Neoplasms; Stomach Neoplasms; Thymidine; Tritium; Uterine Neoplasms | 1965 |
Morphogenesis in Trichoderma: suppression of photoinduction by 5-fluorouracil.
Topics: Carbon Isotopes; Cytosine Nucleotides; DNA; Fluorouracil; In Vitro Techniques; Mitosporic Fungi; Radiometry; RNA; Spores; Thymidine; Uracil; Uracil Nucleotides | 1966 |
Effects of ultraviolet radiation on RNA C-C glycosyls and other derivatives of uracil.
Topics: Chemical Phenomena; Chemistry, Physical; Fluorouracil; Nucleosides; Radiation Effects; RNA, Transfer; Spectrophotometry; Thymidine; Thymine; Ultraviolet Rays; Uracil; Uridine | 1966 |
A model system for examining the action of anti-cancer agents at the cellular level in vivo.
Topics: Animals; Antineoplastic Agents; Azaserine; Cyclophosphamide; Dactinomycin; Fluorouracil; Hematopoiesis; Lymphoma; Mechlorethamine; Methotrexate; Mice; Models, Theoretical; Neoplasm Transplantation; Neoplasms, Experimental; Spleen; Thymidine; Tritium; Vinblastine | 1967 |
Dual function of the lambda prophage repressor.
Topics: Adenine; Coliphages; DNA, Viral; Fluorouracil; Hot Temperature; Leucine; Molecular Biology; Mutation; Thymidine; Viral Proteins | 1967 |
Enhancement of 5 fluorouracil cytotoxicity in synchronized human malignant cells in culture.
Topics: Culture Techniques; DNA, Neoplasm; Fluorouracil; HeLa Cells; Humans; Mitosis; Thymidine; Tritium | 1967 |
Uridine rescue from the lethal toxicity of 5-fluorouracil in mice.
Topics: Animals; Deoxyuridine; Fluorouracil; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; RNA; Thymidine; Uridine | 1982 |
[Autoradiography studies of cell proliferation and the effect of cytostatic agents on the proliferation of normal and tumor cells].
Topics: Animals; Antineoplastic Agents; Autoradiography; Bleomycin; Carcinoma, Ehrlich Tumor; Cell Cycle; Cell Division; Fluorouracil; Jejunum; Mice; Rats; Tegafur; Thymidine; Vincristine | 1983 |
5-fluorouracil modulation of dihydrofolate reductase RNA levels in methotrexate-resistant KB cells.
Topics: Carcinoma; Cell Division; Cell Line; Clone Cells; Fluorouracil; Gene Amplification; Humans; Kinetics; Mouth Neoplasms; Poly A; RNA; RNA, Messenger; RNA, Neoplasm; Tetrahydrofolate Dehydrogenase; Thymidine; Transcription, Genetic | 1983 |
Thymidine enhancement of methotrexate and 5-fluorouracil toxicity in cultured human colon carcinoma.
Topics: Cells, Cultured; Colonic Neoplasms; Drug Interactions; Flow Cytometry; Fluorouracil; Humans; Kinetics; Methotrexate; RNA; Thymidine | 1984 |
Modulation of 5-fluorouracil metabolism by thymidine. In vivo and in vitro studies on RNA-directed effects in rat liver and hepatoma.
Topics: Animals; Body Weight; Bone Marrow; Cell Survival; Fluorouracil; Intestinal Mucosa; Liver; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred Strains; RNA; Thymidine | 1984 |
Clinical pharmacological studies of concurrent infusion of 5-fluorouracil and thymidine in treatment of colorectal carcinomas.
Topics: Colonic Neoplasms; Drug Therapy, Combination; Floxuridine; Fluorouracil; Humans; Infusions, Parenteral; Rectal Neoplasms; Thymidine; Thymine | 1982 |
5-Fluorouracil incorporation in DNA of human breast carcinoma cells.
Topics: Breast Neoplasms; Cell Line; DNA Replication; DNA, Neoplasm; Female; Floxuridine; Fluorouracil; Humans; Kinetics; Phosphorus Radioisotopes; Thymidine; Tritium | 1982 |
Enhancement of the incorporation of 5-fluorodeoxyuridylate into DNA of HL-60 cells by metabolic modulations.
Topics: Cell Line; Deoxyuracil Nucleotides; DNA Replication; DNA, Neoplasm; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Kinetics; Leukemia, Myeloid, Acute; Methotrexate; Thymidine; Tritium | 1983 |
Prognostic factors and in vitro cytotoxic sensitivity in colorectal cancer.
Topics: Antineoplastic Agents; Cell Division; Cell Survival; Cells, Cultured; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Neoplasm Staging; Prognosis; Rectal Neoplasms; Thymidine; Tumor Stem Cell Assay | 1984 |
[Experiences with Volm's short-term tumor test in the primary treatment of ovarian carcinoma].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cell Division; Cells, Cultured; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Resistance; Female; Fluorouracil; Humans; Ovarian Neoplasms; Prognosis; Thymidine; Uridine | 1984 |
[Regulation of enzyme activities involved in pyrimidine synthesis and its application to cancer chemotherapy].
Topics: Administration, Oral; Animals; Deoxyuridine; Dihydrouracil Dehydrogenase (NAD+); DNA, Neoplasm; Drug Synergism; Fluorouracil; Neoplasms, Experimental; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pentosyltransferases; Phosphorylation; Pyrimidines; Sarcoma, Yoshida; Tegafur; Thymidine; Thymine; Uracil; Uridine | 1984 |
Effects of thymidine and thymidine plus 5-fluorouracil on the growth kinetics of a human lymphoid cell line.
Topics: Cell Cycle; Cell Division; Cell Line; Cell Survival; DNA Replication; Floxuridine; Fluorouracil; Humans; Thymidine; Thymine | 1980 |
Role of uridine phosphorylase for antitumor activity of 5'-deoxy-5-fluorouridine.
Topics: Animals; Biotransformation; Floxuridine; Fluorouracil; Leukemia L1210; Male; Mice; Pentosyltransferases; Sarcoma 180; Tegafur; Thymidine; Uridine; Uridine Phosphorylase | 1980 |
Regulation of RNA- and DNA-directed actions of 5-fluoropyrimidines in mouse T-lymphoma (S-49) cells.
Topics: Animals; Cell Cycle; DNA, Neoplasm; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Leukemia, Experimental; Lymphoma; Mice; Pyrimidine Nucleotides; Pyrimidines; RNA, Neoplasm; Thymidine | 1980 |
A combination of 5-fluorouracil and thymidine in advanced colorectal carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Colonic Neoplasms; Drug Synergism; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Metastasis; Rectal Neoplasms; Thymidine | 1984 |
Clinical trial of sequential N-phosphonacetyl-L-aspartate, thymidine, and 5-fluorouracil in advanced colorectal carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Ataxia; Colonic Neoplasms; Confusion; Drug Administration Schedule; Drug Evaluation; Female; Fluorouracil; Humans; Infusions, Parenteral; Male; Middle Aged; Phosphonoacetic Acid; Rectal Neoplasms; Thymidine | 1984 |
Chemotherapeutic efficacy of 5-fluorouracil with concurrent thymidine infusion against transplantable colon tumors in rodents.
Topics: Animals; Colonic Neoplasms; Drug Therapy, Combination; Female; Fluorouracil; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Transplantation; Rats; Rats, Inbred Strains; Thymidine | 1984 |
Critical modulation by thymidine and hypoxanthine of sequential methotrexate-5-fluorouracil synergism in murine L1210 cells.
Topics: Animals; Cell Survival; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Hypoxanthine; Hypoxanthines; Kinetics; Leukemia L1210; Methotrexate; Mice; Thymidine | 1983 |
Combined cytotoxic effect of low-dose 5-fluorouracil and hydroxyurea on 9L cells in vitro.
Topics: Animals; Brain Neoplasms; Cell Line; Cell Survival; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Hydroxyurea; Kinetics; Rats; Thymidine | 1983 |
Factors modifying the synergistic toxicity of deoxycytidine in combination with thymidine plus 5-fluorouracil in HeLa cells.
Topics: Cell Survival; Culture Media; Deoxycytidine; Dose-Response Relationship, Drug; Drug Synergism; Fluorouracil; HeLa Cells; Humans; Hypoxanthine; Hypoxanthines; Interphase; Kinetics; Mitosis; Thymidine | 1983 |
Phase I evaluation of a biochemically designed combination: PALA, thymidine, and 5-FU.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Drug Evaluation; Fluorouracil; Humans; Neoplasms; Nervous System; Phosphonoacetic Acid; Thymidine | 1984 |
Human tissues degrade uridine much less than thymidine. Possible consequence for 5-fluorouracil therapy.
Topics: Animals; Deoxyuridine; Fluorouracil; Humans; In Vitro Techniques; Liver; Mice; Models, Biological; Pentosyltransferases; Pyrimidine Phosphorylases; Rats; Spleen; Thymidine; Tissue Distribution; Uridine | 1984 |
Purine and pyrimidine analogues irreversibly prevent passage of lymphocytes from the G1 to the S phase of the cell cycle.
Topics: Animals; Azaguanine; DNA Replication; Fluorouracil; Humans; Interphase; Lymphocyte Activation; Lymphocytes; Male; Mice; Mice, Inbred BALB C; Potassium; Protein Biosynthesis; Thymidine; Thymidylate Synthase | 1984 |
Effect of coadministration of thymine or thymidine on the antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Biodegradation, Environmental; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Liver; Male; Mice; Phosphorylation; Rats; Sarcoma 180; Sarcoma, Yoshida; Tegafur; Thymidine; Thymidine Phosphorylase; Thymine; Uracil; Uridine; Uridine Phosphorylase | 1980 |
Effect of DNA inhibitors upon DNA synthesis and development of Drosophila embryos.
Topics: Age Factors; Animals; Arabinonucleotides; Cytidine Monophosphate; DNA; Drosophila melanogaster; Fluorouracil; Mitomycins; Nalidixic Acid; Thymidine; Time Factors | 1980 |
Comparing cell kinetic studies of the effect of ftorafur and 5-fluorouracil on the L 1210 ascites tumor.
Topics: Animals; Cell Division; Female; Fluorouracil; Kinetics; Leukemia L1210; Mice; Mitosis; Neoplasm Transplantation; Tegafur; Thymidine; Transplantation, Homologous; Uridine | 1981 |
Nonlinear pharmacokinetics of thymidine, thymine, and fluorouracil and their kinetic interactions in normal dogs.
Topics: Animals; Dogs; Drug Interactions; Fluorouracil; Kinetics; Metabolic Clearance Rate; Thymidine; Thymine | 1983 |
Improving the anti-tumor activity of 5-fluorouracil by increasing its incorporation into RNA via metabolic modulation.
Topics: Animals; DNA, Neoplasm; Drug Synergism; Female; Fluorouracil; Glycoproteins; Mammary Neoplasms, Experimental; Mice; Neoplasm Proteins; RNA, Neoplasm; Thymidine | 1980 |
Effect of excess folates and deoxyinosine on the activity and site of action of 5-fluorouracil.
Topics: Animals; Carcinoma; Cell Line; Deoxyribonucleosides; Deoxyribose; Deoxyuridine; Drug Synergism; Fluorouracil; Humans; Inosine; Leucovorin; Mice; Sarcoma, Experimental; Thymidine; Thymidylate Synthase | 1981 |
Partial protection of the gastric toxicity of regional 5-fluorouracil infusion by thymidine and cimetidine.
Topics: Animals; Cimetidine; Dogs; Fluorouracil; Gastric Acid; Gastric Mucosa; Guanidines; Infusions, Intra-Arterial; Stomach; Stomach Ulcer; Thymidine | 1982 |
A selection system specific for the Thy mutator phenotype.
Topics: Animals; Cell Line; Cell Separation; Cricetinae; Cricetulus; Cytarabine; Deoxyribonucleotides; Drug Resistance; Female; Fluorouracil; Mutation; Ovary; Thymidine | 1982 |
Comparative investigations on the effect of 5-fluorouracil on the epidermis and the skin appendages.
Topics: Animals; Cell Division; Cricetinae; Fluorouracil; Guinea Pigs; Hair; Male; Mesocricetus; Sebaceous Glands; Skin; Thymidine; Time Factors | 1981 |
Failure of 5-fluorouracil and methotrexate to destroy the reproductive integrity of a human breast cancer cell line (MCF-7) growing in vitro.
Topics: Breast Neoplasms; Cell Division; Cell Line; Cell Survival; Clone Cells; Deoxyuridine; DNA, Neoplasm; Dose-Response Relationship, Drug; Fluorouracil; Humans; Male; Methotrexate; Thymidine | 1981 |
Penetration of substances into tumor tissue--a methodological study on cellular spheroids.
Topics: Albumins; Biological Transport; Cell Line; Clone Cells; Fluorouracil; Glioma; Humans; Leucine; Models, Biological; Neoplasms; Thymidine; Vinblastine | 1981 |
Cytotoxic and cytokinetic effects of thymidine, 5-fluorouracil, and deoxycytidine on HeLa cells in culture.
Topics: Cell Division; Cell Survival; Colony-Forming Units Assay; Deoxycytidine; DNA; Dose-Response Relationship, Drug; Fluorouracil; HeLa Cells; Humans; Thymidine; Time Factors | 1981 |
Influence of pH and serum on the effectivity of antineoplastic agents in vitro.
Topics: Antineoplastic Agents; Cells, Cultured; Culture Media; Fluorouracil; Humans; Hydrogen-Ion Concentration; Mesothelioma; Thymidine; Uridine; Vinblastine | 1981 |
Carbocyclic analogues of 5-fluorouracil nucleosides.
Topics: Animals; Antineoplastic Agents; Fluorouracil; Leukemia L1210; Leukemia P388; Mice; Nucleosides; Thymidine | 1981 |
Modulation of 5-FU action by thymidine in murine and human tumors.
Topics: Animals; Drug Evaluation; Drug Interactions; Drug Therapy, Combination; Fluorouracil; Humans; Kinetics; Mice; Neoplasms; Neoplasms, Experimental; Species Specificity; Thymidine | 1981 |
Comparison of pharmacokinetics of 5-fluorouracil and 5-fluorouracil with concurrent thymidine infusions in a Phase I trial.
Topics: Adult; Bone Marrow; Drug Evaluation; Female; Fluorouracil; Half-Life; Humans; Infusions, Parenteral; Male; Middle Aged; Neoplasms; Thymidine | 1980 |
Potentiation of the anti-tumor activity of 5FU by thymidine and its correlation with the formation of (5FU)RNA.
Topics: Animals; Colonic Neoplasms; DNA, Neoplasm; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Mammary Neoplasms, Experimental; Mice; Neoplasms, Experimental; RNA, Neoplasm; Thymidine; Thymidine Kinase | 1980 |
Combination clinical trials with thymidine and fluorouracil: a phase I and clinical pharmacologic evaluation.
Topics: Adult; Aged; Bone Marrow; Colonic Neoplasms; Drug Evaluation; Drug Therapy, Combination; Female; Fluorouracil; Humans; Lymphoma; Middle Aged; Neoplasms; Ovarian Neoplasms; Thymidine | 1980 |
Dynamic histology of a rat hepatoma and the response to 5-fluorouracil.
Topics: Animals; DNA, Neoplasm; Female; Fluorouracil; Kinetics; Liver Neoplasms, Experimental; Mitotic Index; Rats; Rats, Inbred ACI; Thymidine; Uridine | 1980 |
Protection by testosterone from fluorouracil-induced toxicity without loss of anticancer acitvity against autochthonous murine breast tumors.
Topics: Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluorouracil; Leukocyte Count; Male; Mammary Neoplasms, Experimental; Mice; Testosterone; Thymidine | 1980 |
The in vivo incorporation of triated thymidine into liver cell nuclear DNA in mice treated chronically with carbon tetrachloride or with diethylnitrosamine.
Topics: Animals; Bromodeoxyuridine; Carbon Tetrachloride Poisoning; Cell Nucleus; Diethylnitrosamine; DNA; DNA Repair; Fluorouracil; Hydroxyurea; Liver; Mice; Nitrosamines; Thymidine | 1980 |
[Experimental study of the combined effect of 5-fluorouracil and cyclophosphane on growth of Zajdela hepatoma and nucleic acid metabolism].
Topics: Animals; Cyclophosphamide; DNA, Neoplasm; Drug Therapy, Combination; Fluorouracil; Liver Neoplasms, Experimental; Male; Neoplasm Transplantation; Rats; RNA, Neoplasm; Thymidine; Uridine | 1980 |
Clinical pharmacologic effects of thymidine plus 5-FU.
Topics: Adult; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Female; Fluorouracil; Humans; Leukocyte Count; Male; Middle Aged; Neoplasms; Platelet Count; Thymidine; Thymine; Time Factors | 1980 |
Characterization of trimethoprim- and sulphisoxazole-resistant Chlamydia trachomatis.
Topics: Adenosine Triphosphate; Animals; Chlamydia trachomatis; DNA, Bacterial; Drug Resistance, Microbial; Fluorouracil; Guanosine Triphosphate; L Cells; Methotrexate; Mice; Microbial Sensitivity Tests; Mutation; Phenotype; RNA, Bacterial; Sulfisoxazole; Thymidine; Trimethoprim; Uracil; Zidovudine | 1994 |
Fas receptor (CD95)-mediated apoptosis is induced in leukemic cells entering G1B compartment of the cell cycle.
Topics: Acute Disease; Antibodies, Monoclonal; Apoptosis; Cell Division; Child; Child, Preschool; DNA Damage; DNA, Neoplasm; fas Receptor; Fluorouracil; G1 Phase; Humans; Leukemia, Myeloid; Neoplastic Stem Cells; RNA, Neoplasm; Signal Transduction; Tetradecanoylphorbol Acetate; Thymidine; Tumor Cells, Cultured | 1995 |
Increased sensitivity to the prodrug 5'-deoxy-5-fluorouridine and modulation of 5-fluoro-2'-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase.
Topics: Antineoplastic Agents; Biological Availability; Breast; Breast Neoplasms; Cell Communication; Cell Division; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Humans; Prodrugs; Thymidine; Thymidine Phosphorylase; Transfection; Tumor Cells, Cultured | 1995 |
Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil.
Topics: Cell Division; Cell Line; Colonic Neoplasms; DNA, Neoplasm; Drug Resistance; Fluorouracil; Gene Amplification; Humans; RNA, Messenger; Thymidine; Thymidylate Synthase; Up-Regulation | 1995 |
Antibiotic C3368-A, a fungus-derived nucleoside transport inhibitor, potentiates the activity of antitumor drugs.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Benzofurans; Biological Transport; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Cell Division; Colonic Neoplasms; Doxorubicin; Drug Synergism; Female; Fluorouracil; Humans; KB Cells; Liver Neoplasms; Methotrexate; Mice; Mice, Inbred BALB C; Mitomycin; Spiro Compounds; Thymidine; Tumor Cells, Cultured; Tumor Stem Cell Assay; Uridine | 1995 |
Enhanced cytotoxicity with interleukin-1 alpha and 5-fluorouracil in HCT116 colon cancer cells.
Topics: Biotransformation; Cell Division; Colonic Neoplasms; DNA, Neoplasm; Drug Synergism; Fluorouracil; Humans; Interleukin-1; Prodrugs; Receptors, Interleukin-1; Recombinant Proteins; RNA, Neoplasm; Thymidine; Thymine Nucleotides; Tumor Cells, Cultured; Tumor Stem Cell Assay; Uridine; Uridine Triphosphate | 1994 |
SMS 201.995 (Sandostatin) enhances in-vitro effects of 5-fluorouracil in colorectal cancer.
Topics: Adenocarcinoma; Carcinoma; Colonic Neoplasms; Colorimetry; Drug Synergism; Fluorouracil; Humans; Octreotide; Thymidine; Tumor Cells, Cultured | 1995 |
Relationship of variations in tumor cell kinetics induced by primary chemotherapy to tumor regression and prognosis in locally advanced breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Division; Chemotherapy, Adjuvant; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Fluorouracil; Follow-Up Studies; Humans; Mastectomy; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Thymidine | 1994 |
Aberrant cell cycle inhibition pattern in human colon carcinoma cell lines after exposure to 5-fluorouracil.
Topics: Cell Cycle; Colonic Neoplasms; DNA; Drug Interactions; Fluorouracil; Humans; Leucovorin; S Phase; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 1995 |
Dependence of 5-fluorouracil-mediated radiosensitization on DNA-directed effects.
Topics: Cell Cycle; Colonic Neoplasms; DNA; Fluorouracil; Humans; Radiation-Sensitizing Agents; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 1994 |
BIBW 22, a dipyridamole analogue, acts as a bifunctional modulator on tumor cells by influencing both P-glycoprotein and nucleoside transport.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Membrane Permeability; Dipyridamole; Drug Synergism; Fluorouracil; Humans; Membrane Glycoproteins; Morpholines; Nucleosides; Photochemistry; Thymidine; Triamterene; Tumor Cells, Cultured; Vincristine | 1993 |
DNA synthesis after combined treatment with cisplatin and 5-fluorouracil of a mouse ascites tumor growing in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Chromatography, High Pressure Liquid; Cisplatin; Cross-Linking Reagents; DNA, Neoplasm; Fluorouracil; Male; Mice; Neoplasms, Experimental; Thymidine; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured | 1994 |
Semiautomated 14C-thymidine incorporation assay for in vitro screening of anticancer drug.
Topics: Adenocarcinoma; Antineoplastic Agents; Carbon Radioisotopes; Carcinoma, Signet Ring Cell; Cell Division; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Mitomycin; Stomach Neoplasms; Tamoxifen; Thymidine; Tumor Cells, Cultured | 1993 |
Characterization of a 5-fluorouracil-enriched osteoprogenitor population of the murine bone marrow.
Topics: Alkaline Phosphatase; Animals; Bone Marrow; Bone Marrow Cells; Calcium; Cell Adhesion; Cells, Cultured; Collagen; Colony-Forming Units Assay; DNA; Durapatite; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Fluorouracil; Hematopoietic Stem Cells; In Situ Hybridization; Kinetics; Mice; Mice, Inbred BALB C; Microscopy, Electron; Microscopy, Electron, Scanning; Minerals; Nylons; Osteoblasts; Osteocalcin; Plastics; Stem Cells; Thymidine; X-Ray Diffraction | 1993 |
Effects of 5-fluorouracil on embryonic rat palate in vitro: fusion in the absence of proliferation.
Topics: Animals; Cell Cycle; Cell Division; Cleft Palate; DNA; Embryo, Mammalian; Fluorouracil; Gestational Age; Organ Culture Techniques; Palate; Rats; Rats, Sprague-Dawley; Thymidine | 1993 |
5-Fluorouracil metabolism and cytotoxicity after pre-treatment with methotrexate or thymidine in human hypopharynx and colon carcinoma xenografts: a 19F-nuclear magnetic resonance spectroscopy study in vivo.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma; Colonic Neoplasms; Fluorine Radioisotopes; Fluorouracil; Humans; Magnetic Resonance Spectroscopy; Methotrexate; Mice; Mice, Nude; Pharyngeal Neoplasms; Thymidine; Transplantation, Heterologous | 1996 |
Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation.
Topics: Animals; Apoptosis; Colon; Enzyme Inhibitors; Fluorouracil; Folic Acid Antagonists; Gene Expression Regulation; Histocytochemistry; Immunohistochemistry; Intestinal Mucosa; Intestine, Small; Male; Mice; Mice, Inbred Strains; Quinazolines; RNA; Thiophenes; Thymidine; Thymidylate Synthase; Tumor Suppressor Protein p53; Uridine | 1997 |
Cell proliferation as a predictor of response to chemotherapy in metastatic breast cancer: a prospective study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Division; Cyclophosphamide; Epirubicin; Female; Fluorouracil; Humans; Methotrexate; Middle Aged; Neoplasm Metastasis; Prognosis; Prospective Studies; Thymidine; Tumor Cells, Cultured | 1997 |
Irreversible cytotoxic effect of a novel lowly immunosuppressive antitumor fluorouridine derivative, UK-21.
Topics: Antimetabolites, Antineoplastic; Cell Cycle; Cell Survival; Flow Cytometry; Floxuridine; Fluorouracil; Glycine; Humans; Immunosuppressive Agents; KB Cells; Neoplastic Stem Cells; Thymidine; Uridine | 1997 |
Inhibition by 5-fluorouracil of ERCC1 and gamma-glutamylcysteine synthetase messenger RNA expression in a cisplatin-resistant HST-1 human squamous carcinoma cell line.
Topics: Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Cisplatin; DNA Repair; DNA Topoisomerases, Type I; DNA-Binding Proteins; Drug Resistance, Neoplasm; Endonucleases; Fluorouracil; Gene Expression Regulation, Neoplastic; Glutamate-Cysteine Ligase; Humans; Proteins; RNA, Messenger; RNA, Neoplasm; Thymidine | 1997 |
Nucleoside-mediated mitigation of 5-fluorouracil-induced toxicity in synchronized murine erythroleukemic cells.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Cycle; Deoxycytidine; Deoxyguanine Nucleotides; Embryo, Mammalian; Female; Flow Cytometry; Fluorouracil; Leukemia, Erythroblastic, Acute; Mice; Pregnancy; Rats; Rats, Sprague-Dawley; Thymidine; Thymine Nucleotides | 1997 |
5-Fluorouracil-resistant colonic tumors are highly responsive to sodium butyrate/interleukin-2 bitherapy in rats.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Butyrates; Butyric Acid; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Fluorouracil; Interleukin-2; Mice; Mice, Nude; Neoplasm Transplantation; Rats; Rats, Inbred Strains; Recombinant Proteins; Survival Rate; Thymidine; Tumor Cells, Cultured | 1997 |
Dihydropyrimidine dehydrogenase in livers from mouse and rat, and in human liver, colon tumors, and mucosa in relation to anabolism of 5-fluorouracil.
Topics: Animals; Biological Availability; Biotransformation; Colonic Neoplasms; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans; Intestinal Mucosa; Kinetics; Liver; Mice; Oxidoreductases; Rats; Species Specificity; Thymidine; Thymine; Uracil | 1998 |
A pharmacokinetic and pharmacodynamic study in vivo of human HT29 tumours using 19F and 31P magnetic resonance spectroscopy.
Topics: Animals; Antineoplastic Agents; Fluorouracil; HT29 Cells; Humans; Interferon-alpha; Liver Neoplasms, Experimental; Magnetic Resonance Spectroscopy; Mice; Mice, Nude; Neoplasm Transplantation; Thymidine | 1997 |
Antitumor activity of ZD1694 (tomudex) against human head and neck cancer in nude mouse models: role of dosing schedule and plasma thymidine.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Quinazolines; Thiophenes; Thymidine; Transplantation, Heterologous; Tumor Cells, Cultured | 1999 |
An update on thymidylate synthase inhibitors.
Topics: Antimetabolites, Antineoplastic; Fluorouracil; Humans; Neoplasms; Thymidine; Thymidylate Synthase | 1999 |
Thymidine kinase, thymidylate synthase, and dihydropyrimidine dehydrogenase profiles of cell lines of the National Cancer Institute's Anticancer Drug Screen.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cell Line; Databases, Factual; Dihydrouracil Dehydrogenase (NADP); DNA; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Humans; Mutation; National Institutes of Health (U.S.); Oxidoreductases; RNA, Messenger; Thymidine; Thymidine Kinase; Thymidylate Synthase; Tumor Cells, Cultured; Tumor Suppressor Protein p53; United States | 2001 |
Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Colonic Neoplasms; Diet; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Fluorouracil; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Leucovorin; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Pemetrexed; Quinazolines; Thiophenes; Thymidine; Thymidine Kinase; Thymidylate Synthase | 2001 |
Serum factors attenuating the anti-tumor activity of 5-fluorouracil.
Topics: Antimetabolites, Antineoplastic; Colonic Neoplasms; Cytokines; DNA, Neoplasm; Drug Interactions; Drug Resistance; Fluorouracil; Humans; Immunoblotting; Interferon-gamma; Interleukin-1; Interleukin-6; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2001 |
Lymphoblasts already in the DNA synthesis phase of the cell cycle can be reversibly arrested at the R/G transition.
Topics: Bromodeoxyuridine; Cell Cycle; Cell Line, Transformed; Chromosome Banding; Chromosomes, Human; DNA; DNA Replication; Flow Cytometry; Fluorouracil; Humans; Karyotyping; Kinetics; Lymphocyte Activation; Lymphocytes; Methotrexate; Mimosine; S Phase; Thymidine | 2001 |
Turnover of thymidine in the DNA of marrow and intestinal mucosa in mice, and its response to administration of 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Bone Marrow; DNA; Fluorouracil; Intestinal Mucosa; Mice; Nucleosides; Nucleotides; Thymidine; Uracil | 1961 |
[Studies on the mechanism of induction. I. The effect of some base analogs on lysogenic bacteria].
Topics: Bacteria; Culture Media; Escherichia coli; Floxuridine; Fluorouracil; Lysogeny; Thymidine | 1963 |
The coupled formation of deoxyribonucleic acid, nuclear ribonucleic acid and protein in animal-cell cultures.
Topics: Cell Culture Techniques; DNA; Floxuridine; Fluorouracil; Nucleosides; Proteins; RNA; Thymidine; Tissue Culture Techniques | 1962 |
Effects of uracil and thymidine on the development of resistance to 5-fluorouracil in Pediococcus cerevisiae.
Topics: Deoxyuridine; Fluorouracil; Pediococcus; Thymidine; Uracil | 1963 |
KINETIC STUDY OF THE INHIBITION OF GROWTH OF ROUS SARCOMA VIRUS AND CELLS BY 5-FLUOROURACIL IN VITRO.
Topics: Animals; Avian Sarcoma Viruses; Chick Embryo; Culture Media; Fluorouracil; In Vitro Techniques; Research; Rous sarcoma virus; Thymidine; Virus Cultivation | 1963 |
NUCLEIC ACID METABOLISM AND BACTERIOPHAGE MULTIPLICATION: EFFECTS OF 5-FLUOROURACIL ON COLIPHAGE SYNTHESIS.
Topics: Bacteriophages; Coliphages; DNA; DNA, Viral; Fluorouracil; RNA; RNA, Viral; Thymidine; Uracil | 1963 |
EFFECT OF 5-FLUOROURACIL ON REGENERATION IN TADPOLES.
Topics: Animals; Anura; DNA; Fluorouracil; Larva; Metabolism; Pharmacology; Regeneration; Research; Thymidine; Tritium | 1963 |
INDUCTION BY 5-FLUOROURACIL OF BACTERIOPHAGE DEVELOPMENT IN LYSOGENIC E. COLI K12 (LAMBDA).
Topics: Bacteriophages; Coliphages; Escherichia coli; Fluorouracil; Lysogeny; Research; Thymidine; Uracil | 1963 |
EFFECTS OF 5-FLUOROURACIL, ACTINOMYCIN D AND MITOMYCIN C ON THE INDUCTION OF THYMIDINE KINASE BY VACCINIA-INFECTED L-CELLS.
Topics: Dactinomycin; DNA; DNA, Viral; Enzyme Inhibitors; Floxuridine; Fluorouracil; Metabolism; Mice; Mitomycin; Mitomycins; Pharmacology; Phosphotransferases; Research; RNA; RNA, Viral; Thymidine; Thymidine Kinase; Tissue Culture Techniques; Tritium; Vaccinia; Vaccinia virus; Virus Cultivation | 1963 |
EFFECT OF HALOGENATED PYRIMIDINES AND THYMIDINE ON GROWTH OF L-CELLS AND A SUBLINE LACKING THYMIDINE KINASE.
Topics: Animals; Connective Tissue; Fluorouracil; L Cells; Metabolism; Mice; Pharmacology; Phosphotransferases; Pyrimidines; Research; Thymidine; Thymidine Kinase; Tissue Culture Techniques; Tritium | 1964 |
UTILIZATION OF DNA AND RNA PRECURSORS AS INDICATORS OF DRUG EFFECT ON CANCER CELLS. ANL-6723.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Dactinomycin; DNA; DNA, Neoplasm; Fluorouracil; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Mechlorethamine; Mice; Neoplasms; Nucleosides; Pharmacology; Research; RNA Precursors; Thymidine; Tritium | 1963 |
THE CLINICAL EFFECTS OF THE CONTINUOUS INTRAVENOUS INFUSION OF CANCER CHEMOTHERAPEUTIC COMPOUNDS.
Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Antineoplastic Agents; Floxuridine; Fluorouracil; Infusions, Intravenous; Infusions, Parenteral; Methotrexate; Mitomycin; Mitomycins; Neoplasms; Thymidine | 1964 |
THE EFFECT OF NATURAL AND UNNNATURAL PYRIMIDINES AND PYRIMIDINE NUCLEOSIDES ON THE PHOSPHOROLYSIS OF 5-IODODEOXYURIDINE BY MOUSE LIVER EXTRACT.
Topics: Animals; Chromatography; Deoxyuridine; Floxuridine; Fluorouracil; Idoxuridine; Iodine Isotopes; Liver; Liver Extracts; Metabolism; Mice; Nucleosides; Pharmacology; Phosphotransferases; Pyrimidine Nucleosides; Pyrimidines; Research; Thymidine; Thymine; Uracil | 1964 |
THE ROLE OF DEOXYRIBONUCLEIC ACID IN THE SYNTHESIS OF ROUS SARCOMA VIRUS.
Topics: Animals; Avian Sarcoma Viruses; Colchicine; Dactinomycin; DNA; DNA, Neoplasm; DNA, Viral; Fluorouracil; Neoplasms; Nucleosides; Pharmacology; Poultry; Research; Rous sarcoma virus; Thymidine | 1964 |
STUDIES ON THE REPLICATING POOL OF VIRAL DNA IN CELLS INFECTED WITH PSEUDORABIES VIRUS.
Topics: Adenine; Antiviral Agents; Carbon Isotopes; Cesium; Deoxyribonucleases; DNA; DNA, Viral; Fluorouracil; Herpesviridae; Herpesvirus 1, Suid; Nucleosides; Pharmacology; Research; Simplexvirus; Thymidine; Tissue Culture Techniques; Virus Cultivation | 1964 |
COMBINATION OF SURGERY AND CHEMOTHERAPY IN THE TREATMENT OF ORAL CANCER.
Topics: DNA; DNA, Neoplasm; Drug Therapy; Fluorouracil; Humans; Methotrexate; Mouth Neoplasms; Neck Dissection; Neoplasms; Surgical Procedures, Operative; Thymidine | 1964 |
SUBSTRATE SPECIFICITY AND INDUCTION OF THYMIDINE PHOSPHORYLASE IN ESCHERICHIA COLI.
Topics: Chloramphenicol; Escherichia coli; Fluorouracil; Glucosyltransferases; Nucleosides; Pharmacology; Research; Substrate Specificity; Thymidine; Thymidine Phosphorylase; Uracil | 1964 |
EFFECTS OF URACIL MUSTARD ON IN VIVO INCORPORATION OF PRECURSORS INTO NUCLEIC ACIDS OF THE WALKER TUMOR.
Topics: Animals; Carcinoma; Carcinoma 256, Walker; DNA; DNA, Neoplasm; Fluorouracil; Kinetics; Metabolism; Nitrogen Mustard Compounds; Nucleic Acids; Pharmacology; Rats; Research; RNA; RNA, Neoplasm; Thymidine; Uracil Mustard | 1964 |
UPTAKE AND INCORPORATION OF THYMINE, THYMIDINE, URACIL, URIDINE, AND 5-FLUOROURACIL INTO THE NUCLEIC ACIDS OF BACILLUS SUBTILIS.
Topics: Bacillus subtilis; Carbon Isotopes; DNA; DNA, Bacterial; Fluorouracil; Metabolism; Nucleosides; Research; RNA; RNA, Bacterial; Thymidine; Thymine; Tritium; Uracil; Uridine | 1965 |
PYRIMIDINE METABOLISM IN TISSUE CULTURE CELLS DERIVED FROM RAT HEPATOMAS. I. SUSPENSION CELL CULTURES DERIVED FROM THE NOVIKOFF HEPATOMA.
Topics: Animals; Carcinoma, Hepatocellular; Cell Culture Techniques; Floxuridine; Fluorouracil; Glycine; Liver Neoplasms; Liver Neoplasms, Experimental; Metabolism; Methotrexate; Mutation; Neoplasms; Neoplasms, Experimental; Nucleosides; Pharmacology; Pyrimidines; Rats; Research; Serine; Thymidine; Thymidine Kinase; Thymine; Tissue Culture Techniques; Toxicology; Uracil | 1965 |
EVIDENCE FOR CYTOPLASMIC DNA IN ROOT CELLS OF NICOTIANA.
Topics: Autoradiography; Cell Nucleus; Cytoplasm; Dactinomycin; Deoxyribonucleases; DNA; DNA Replication; Fluorouracil; Kinetics; Metabolism; Mitomycin; Mitomycins; Nicotiana; Nucleosides; Research; Ribonucleases; RNA; Thymidine; Tritium | 1965 |
AMINO ACID REGULATION OF BACTERIOPHAGE RNA SYNTHESIS.
Topics: Amino Acids; Bacteriophages; Chloramphenicol; Coliphages; Fluorouracil; Metabolism; Molecular Biology; Mutation; Pharmacology; Research; RNA; RNA, Viral; Thymidine | 1965 |
Effects of 5-fluorodeoxyuridine and related halogenated pyrimidines on the sand-dollar embryo.
Topics: Cytidine; DNA; Female; Floxuridine; Fluorouracil; Humans; Orotic Acid; Pregnancy; Pyrimidines; Thymidine; Thymine; Uridine | 1960 |
Phytohemagglutinin inhibits lymphoid tumor growth in vitro and in vivo.
Topics: Animals; Annexin A5; Antimetabolites, Antineoplastic; Apoptosis; Cell Cycle; Drug Combinations; Drug Synergism; Fluorouracil; In Vitro Techniques; Lymphoma, B-Cell; Lymphoma, T-Cell; Male; Mice; Mice, SCID; Phytohemagglutinins; Thymidine; Tumor Cells, Cultured | 2003 |
Overproduction of thymidine by recombinant brevibacterium helvolum amplified with thymidine monophosphate phosphohydrolase gene from bacteriophage PBS2.
Topics: Bacterial Proteins; Bacteriophages; Brevibacterium; Chromatography, High Pressure Liquid; Cloning, Molecular; Drug Resistance, Bacterial; Fermentation; Fluorouracil; Hydroxyurea; Mutation; Nucleotidases; Phosphoric Monoester Hydrolases; Plasmids; Recombinant Proteins; Thymidine; Thymidine Monophosphate; Trimethoprim | 2004 |
A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Death; DNA Damage; DNA Topoisomerases, Type I; DNA, Neoplasm; DNA, Single-Stranded; Drug Screening Assays, Antitumor; Fluorodeoxyuridylate; Fluorouracil; Leukemia P388; Mice; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Topoisomerase I Inhibitors | 2005 |
Elevation of radiolabelled thymidine uptake in RIF-1 fibrosarcoma and HT29 colon adenocarcinoma cells after treatment with thymidylate synthase inhibitors.
Topics: Adenocarcinoma; Biological Transport, Active; Cell Line, Tumor; Cell Survival; Cisplatin; Colonic Neoplasms; Enzyme Inhibitors; Fibrosarcoma; Fluorouracil; HT29 Cells; Humans; Quinazolines; Radionuclide Imaging; Radiopharmaceuticals; Thymidine; Thymidylate Synthase; Time Factors; Tritium | 2006 |
Trypanosoma brucei: a survey of pyrimidine transport activities.
Topics: Animals; Antimetabolites; Biological Transport; Cytidine; Cytosine; Female; Fluorouracil; Parasitic Sensitivity Tests; Pyrimidines; Rats; Rats, Wistar; Thymidine; Thymine; Trypanocidal Agents; Trypanosoma brucei brucei; Uridine | 2006 |
The role of thymidine phosphorylase and uridine phosphorylase in (fluoro)pyrimidine metabolism in peripheral blood mononuclear cells.
Topics: Cells, Cultured; Floxuridine; Fluorouracil; Humans; Inhibitory Concentration 50; Leukocytes, Mononuclear; Pyrimidines; RNA; Substrate Specificity; Thymidine; Thymidine Phosphorylase; Uridine Phosphorylase | 2006 |
Altered deoxyuridine and thymidine in plasma following capecitabine treatment in colorectal cancer patients.
Topics: Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Deoxyuridine; Female; Fluorouracil; Humans; Male; Thymidine | 2007 |
Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect.
Topics: Animals; Animals, Newborn; Bone Marrow Cells; Cell Cycle; Cell Proliferation; Chemokine CXCL12; Chemokines, CXC; Fluorouracil; Gene Expression; Graft Survival; Hematopoiesis; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Hematopoietic System; Hyaluronan Receptors; Integrin alpha4; Liver; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-kit; Receptors, CXCR4; Thymidine; Vascular Cell Adhesion Molecule-1 | 2006 |
Mechanisms of acquired chemoresistance to 5-fluorouracil and tomudex: thymidylate synthase dependent and independent networks.
Topics: Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Fluorouracil; Humans; NF-kappa B; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2007 |
Influence of dTMP on the phenotypic appearance and intracellular persistence of Staphylococcus aureus.
Topics: Anti-Bacterial Agents; Cell Line; Cystic Fibrosis; Dihydropteroate Synthase; Fluorouracil; Folic Acid Antagonists; Humans; Lung; Phenotype; Staphylococcus aureus; Thymidine; Trimethoprim, Sulfamethoxazole Drug Combination; Uridine | 2008 |
Cannabinoid receptor-independent cytotoxic effects of cannabinoids in human colorectal carcinoma cells: synergism with 5-fluorouracil.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antioxidants; Cannabinoid Receptor Antagonists; Cannabinoids; Cell Proliferation; Cell Survival; Colonic Neoplasms; Cyclic AMP; Dronabinol; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Fatty Acids, Unsaturated; Fluorouracil; Humans; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidative Stress; Piperidines; Pyrazoles; Receptors, Cannabinoid; Thymidine; Tumor Cells, Cultured | 2009 |
[18F]FDG and [18F]FLT uptake in human breast cancer cells in relation to the effects of chemotherapy: an in vitro study.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Doxorubicin; Fluorodeoxyglucose F18; Fluorouracil; Humans; Paclitaxel; Thymidine; Thymidine Kinase | 2008 |
Novel opportunities for thymidylate metabolism as a therapeutic target.
Topics: Adenocarcinoma; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Computational Biology; DNA Damage; Drug Design; Drug Resistance, Neoplasm; Fluorouracil; Humans; Immunohistochemistry; Pyrophosphatases; Reproducibility of Results; Thymidine | 2008 |
Limits to thymidylate synthase and TP53 genes as predictive determinants for fluoropyrimidine sensitivity and further evidence for RNA-based toxicity as a major influence.
Topics: Alleles; Antimetabolites, Antineoplastic; Base Sequence; Cell Line, Tumor; Colorectal Neoplasms; Fluorouracil; Genes, p53; HCT116 Cells; Humans; Molecular Sequence Data; Mutation; RNA, Messenger; RNA, Neoplasm; Thymidine; Thymidylate Synthase; Uridine; Yeasts | 2009 |
Effects of 5-FU on DNA synthesis and cytotoxicity of human lymphocytes induced by IL-2, TGF-beta3 and PGE2.
Topics: Cell Cycle; Cells, Cultured; Culture Media; Cytotoxicity, Immunologic; Dinoprostone; DNA; Drug Interactions; Fluorouracil; Humans; Interleukin-2; Lymphocyte Activation; Lymphocytes; Receptors, Interleukin-2; Thymidine; Transforming Growth Factor beta3 | 2009 |
Imaging colon cancer response following treatment with AZD1152: a preclinical analysis of [18F]fluoro-2-deoxyglucose and 3'-deoxy-3'-[18F]fluorothymidine imaging.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Dideoxynucleosides; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Fluorouracil; HCT116 Cells; Humans; Immunoblotting; Ki-67 Antigen; Methotrexate; Mice; Mice, Nude; Organophosphates; Positron-Emission Tomography; Quinazolines; Radiopharmaceuticals; Thymidine; Thymidine Kinase; Xenograft Model Antitumor Assays | 2011 |
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.
Topics: Animals; Cell Cycle; Cell Line, Tumor; DNA; DNA Damage; DNA Repair; Endodeoxyribonucleases; Floxuridine; Fluorouracil; Gene Knockdown Techniques; Humans; Mice; MutS Homolog 2 Protein; RNA; Thymidine; Thymine DNA Glycosylase; Uracil-DNA Glycosidase; Uridine | 2011 |
Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice.
Topics: Animals; beta-Galactosidase; Cell Line; DNA Repair; Fibroblasts; Fluorouracil; Gene Targeting; Genetic Predisposition to Disease; Longevity; Mice; Mice, Inbred C57BL; Mice, Knockout; MutS Homolog 2 Protein; Neoplasms, Experimental; Pentoxyl; Thymidine; Uracil-DNA Glycosidase | 2012 |
Low-temperature NMR studies on the geometry of base pairs involving 5-substituted uracil derivatives.
Topics: Adenosine; Base Pairing; Bromouracil; Cold Temperature; Fluorouracil; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Nitrogen Isotopes; Thymidine; Uracil; Uridine | 2013 |
Attenuation of nucleoside and anti-cancer nucleoside analog drug uptake in prostate cancer cells by Cimicifuga racemosa extract BNO-1055.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Bromodeoxyuridine; Cell Line; Cell Proliferation; Cimicifuga; Deoxycytidine; Dose-Response Relationship, Drug; Equilibrative Nucleoside Transport Proteins; Fluorouracil; Gemcitabine; Humans; Male; Nucleosides; Phytotherapy; Plant Extracts; Prostate; Prostatic Neoplasms; RNA, Small Interfering; Saponins; Thymidine; Vidarabine | 2013 |
Kinetics and mechanistic study of competitive inhibition of thymidine phosphorylase by 5-fluoruracil derivatives.
Topics: Antimetabolites; Binding Sites; Binding, Competitive; Dimyristoylphosphatidylcholine; Escherichia coli; Escherichia coli Proteins; Fluorouracil; Kinetics; Liposomes; Molecular Docking Simulation; Molecular Structure; Protein Binding; Protein Structure, Tertiary; Thymidine; Thymidine Phosphorylase | 2016 |
Inhibition of thymidylate synthase affects neural tube development in mice.
Topics: Animals; Apoptosis; Cell Proliferation; Deoxyuracil Nucleotides; Embryonic Development; Fluorouracil; Mice, Inbred C57BL; Neural Tube; Neural Tube Defects; Neuroepithelial Cells; Thymidine; Thymidylate Synthase | 2018 |
Thymidine Metabolism as a Confounding Factor for 3'-Deoxy-3'-
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Artifacts; Biological Transport; Cell Transformation, Neoplastic; Colorectal Neoplasms; Dideoxynucleosides; Diffusion Magnetic Resonance Imaging; Female; Fluorouracil; HCT116 Cells; Humans; Leucovorin; Mice; Organoplatinum Compounds; Thymidine | 2018 |