fluorouracil and tegafur

fluorouracil has been researched along with tegafur in 1372 studies

Research

Studies (1,372)

TimeframeStudies, this research(%)All Research%
pre-1990456 (33.24)18.7374
1990's213 (15.52)18.2507
2000's399 (29.08)29.6817
2010's273 (19.90)24.3611
2020's31 (2.26)2.80

Authors

AuthorsStudies
Hashimoto, S; Moriyama, A; Suzue, T; Unemi, N; Yasumoto, M1
Hashimoto, S; Marunaka, T; Yamawaki, I; Yasumoto, M1
Benjamin, RS; Lin, AJ; Loo, TL; Rao, PN1
Ferguson, PW; Holshouser, MH; Shipp, AM1
Antonini, I; Cosby, LA; Kirkpatrick, DL; Lin, TS; Sartorelli, AC; Shiba, DA; Wang, L1
Cook, AF; Holman, MJ; Kramer, MJ1
Hronowski, LJ; Szarek, WA1
Levin, VA1
Fukawa, K; Haga, S; Hiiragi, M; Irino, O; Kametani, T; Kigasawa, K; Nagamatsu, Y; Nakayama, M; Nishimura, N; Okada, T; Sugi, H; Taguchi, A; Wakisaka, K; Yamamoto, T1
Fujiwara, H; Kai, J; Masuda, T; Nakamura, K; Ueda, I1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1
Chen, IC; Chen, MC; Hsu, KC; Lai, MJ; Li, YH; Liao, YH; Lien, ST; Liou, JP; Liu, YM; Pan, SL; Wu, WC1
Han, H; Qi, XR; Shen, L; Tang, HF; Xu, QZ; Yang, WS; Yi, YH; Yuan, CH1
Gilev, AP; Khagi, KhB; Meĭren, DV; Sniedze, TN; Urbanovich, EL1
Akiyoshi, H; Fujii, S; Minato, Y; Okuda, H; Toide, H1
Mayr, AC1
Asserkritova, IV; Garin, AM; Lichinitser, MR; Perevodchikova, NI; Vaarik, GKh1
Drago, JR; Gershwin, ME; Goldman, LB; Maurer, RE1
Lelieveld, P; Pantarotto, C; Salmona, M; Spreafico, F; van Putten, LM1
Hiraiwa, K; Ichikawa, H; Kaneda, T1
Soejima, S1
Hashimoto, S; Ueda, S; Yamashita, J; Yasumoto, M1
Pogosiants, EE; Sokova, OI; Volgareva, GM3
Ariyama, J; Izumi, T; Kurihara, M; Miyasaka, K; Shirakabe, H1
Bodey, GP; Issell, BF; Valdivieso, M1
Hobara, N; Nagashima, H; Watanabe, A1
Hobara, N; Watanabe, A2
Akao, T; Fujimoto, S; Itoh, B; Koshizuka, I; Koyano, K1
Benvenuto, JA; Loo, TL; Lu, K1
Borisov, VI; Buracheskaia, NV; Karam, M; Lipatov, AM; Shkarenkov, VA1
Bukharova, IK; Golubeva, VA; Osipov, NE1
Sokova, OI; Volgareva, GM2
Chao, LY; Saunders, PP1
Kucerová, E; Tománková, H1
Gilev, AP; Kozhukhov, AN; Meĭren, DV1
Fukawa, O; Hori, S; Mori, T; Sato, T1
Aledseev, VM; Blokhina, NG; Smolianskaia, AZ; Sokolova, VD1
Misawa, S; Ohkuma, S; Sawai, K; Sonoda, Y; Takino, T1
Bedikian, A; Bodey, GP; Burgess, MA; Hersh, EM; Mavligit, GM; Rodriguez, V; Valdivieso, M1
Benjamin, RS; Hall, SW; Valdivieso, M1
Baker, L; Buroker, T; McKenzie, M; Miller, A; Samson, M; Vaitkevicius, VK1
Diggs, CH; Smyth, AC; Wiernik, PH1
Andrzejewski, D; Brukwinski, W; Burke, M; Godefroi, VC; Hills, EB; Horwitz, JP; O'Leary, IA1
Au, JL; Sadée, W; Wu, AT1
Dovzhanskiĭ, SI; Suvorov, AP1
Hikasa, Y; Kato, T; Kojima, T; Nomura, Y; Shioda, R1
Ogawa, M1
Baker, L; Buroker, T; DeMattia, M; Dindogru, A; Groth, C; Vaitkevicius, VK; Wojtaszak, B1
Romanenko, NV; Smolianskaia, AZ1
Honda, H1
Shioda, R1
Benjamin, RS; Benvenuto, JA; Hall, SW; Loo, TL; Lu, K1
Kinami, Y; Miyazaki, H; Odagiri, S; Shinmura, K1
Horio, T; Ikai, K; Murai, T1
Benjamin, RS; Benvenuto, JA; Hall, SW; Loo, TL; Lu, K; McKelvey, EM1
Sokova, OI1
Babaian, LA; Borisov, VI; Perevodchikova, NI; Vaarik, KhM; Voznyĭ, EK1
Hashimoto, S; Yamashita, J; Yasumoto, M1
Au, JL; Friedman, MA; Sadée, W; Wu, AT1
Cohen, AM; Dethlefsen, LA; Gray, JW; Pallavicini, MG1
Izumi, T; Kamano, T; Kishino, H; Kurihara, M; Maruyama, T; Minakami, T; Miyasaka, K; Shirakabe, H; Yamaya, F1
Hattori, T; Koh, T; Nakano, A; Niimoto, M; Nishimawari, K; Oride, M; Takiyama, W1
Dalgat, DM1
Buroker, T; Groppe, C; Guy, G; Heilbrun, L; Hoogstraten, B; McCracken, J; Padilla, F; Quagliana, J; Vaitkevicius, VK1
Benvenuto, JA; Caprioli, RM; Farquhar, D; Liehr, JG; Loo, TL; Winkler, T1
Fujimoto, S; Ishigami, H; Itoh, K; Kimura, K; Minami, T; Miyazaki, M1
Hartwich, G2
Fujii, S; Ikenaka, K; Kitano, S; Shirasaka, T1
Hahn, S; Kim, DS1
Blumenschein, GR; Bodey, GP; Burgess, MA; Buzdar, AU; Gutterman, JU; Hersh, EM; Hortobagyi, GN; Livingston, RB; Tashima, CK; Valdivieso, M1
Belt, RJ; Stephens, R1
Au, JL; Sadée, W4
Denine, EP; Giles, HD; Harrison, SD1
Arnold, H; Drings, P; Geldmacher, J; Hartwich, G; Kredel, L; Mayer, M; Neidhardt, B; Queisser, W; Rösch, W; Schaefer, J; von Oldershausen, HF; Wahrendorf, J1
Belitskiĭ, GA; Bukhman, VM; Konopleva, IA1
Haller, DG; Hoth, DF; MacDonald, JS; Rosenoff, S; Schein, PS; Smythe, T; Woolley, PV1
Hara, Y1
Benjamin, RS; Bodey, GP; Hall, SW; Murphy, WK; Valdivieso, M1
Benjamin, RS; Blumenschein, GR; Bodey, GP; Buzdar, AU; Gutterman, JU; Hortobagyi, GN; Krutchik, AN; Tashima, CK; Yap, HY1
Facchinetti, T; Fanelli, R; Filippeschi, S; Pantarotto, C; Salmona, M; Spreafico, F1
Emmerling, DC; Freudenthal, RI1
Kato, Y; Kawashima, Y; Kitade, F; Okada, K; Okajima, K; Osawa, N; Sakuramoto, K; Sekimoto, T; Yagi, A; Yamada, S1
Voznyĭ, EK1
Apinis, TA; Gilev, AP; Meĭrena, DV; Zhuk, RA; Zilbere, AM1
Blokhin, NN1
Garibjanian, BT; Gaston, MR; Goldin, A; Houchens, DP; Johnson, RK; Kline, I; Syrkin, AB1
Gang, M; Garibjanian, BT; Goldin, A; Johnson, RK; Kline, I; Vadlamudi, S; Venditti, JM1
Baumanis, EA; Brusovanik, VI; Iablonovskaia, LIa; Kalnina, IE1
Krusanova, NI; Kubatkina, EI; Potapov, SL; Sevast'ianova, LA; Vasil'eva, NN1
Aoki, K; Nose, H; Okada, S; Okazaki, N; Yoshimori, M1
Abe, R; Arima, S; Fukuyama, N; Hisatsugu, T; Kuroda, Y; Nakamura, Y; Ohkuma, R; Ohsato, K; Yamamoto, H; Yamanouchi, A1
Kato, T; Kitaichi, K; Koda, A; Mori, H; Sakamoto, O1
Inaba, S; Kawai, K; Kondo, Y; Ogino, A; Tsuchiya, K; Ueda, Y; Umeda, T1
Hosoda, Y; Miyakawa, T; Okamura, H; Okubo, S; Oshima, Y; Shiina, E; Shimizu, M; Suda, Y; Tokura, Y; Uchida, K1
Baba, E; Fukushima, T; Kataoka, A; Kondo, Y; Masuko, H; Ohmori, K; Ohsawa, S; Sawaguchi, Y; Shiroto, H; Takahashi, T1
Harada, M; Koga, K; Miura, I; Nishitani, H; Umeno, Y1
Oguro, Y1
Aziz Rani, A; Chudahman, M; Dharmika, D; Ismail Ali, A; Simadibrata, R1
Emi, Y; Kohnoe, S; Maehara, Y; Sugimachi, K; Takahashi, I; Yoshida, M1
Kanazawa, K; Kon, T; Konishi, F; Kotake, K; Koyama, Y; Namba, M; Nara, K; Nozawa, K; Shida, S; Umemoto, S1
Baba, H; Emi, Y; Kohnoe, S; Kusumoto, H; Maehara, Y; Sugimachi, K; Takahashi, I; Yoshida, M1
Hatta, Y; Kanda, M; Kikuchi, H; Kunimura, T; Miura, K; Morohoshi, T; Sato, M; Taguchi, S1
Kusumoto, T; Miyagi, M; Nakashima, T1
Kanamaru, R; Wakui, A1
Akagi, M; Kakegawa, T; Maehara, Y; Shimazu, H; Sugimachi, K; Tomita, M1
Hirano, T; Ifuku, M; Ishikawa, H; Kusano, H; Nakagoe, T; Shimizu, T; Tomita, M1
Akino, H; Isomatu, Y; Kanimoto, Y; Miwa, Y; Okada, K; Suzuki, Y1
Shparyk, IaV1
Gotoh, M; Katsura, Y; Nomoto, K; Noritake, M; Shinomiya, N; Tsuru, S1
Bosse, C; Czejka, MJ; Fogl, U; Jäger, W; Schüller, J1
Anai, H; Emi, Y; Kohnoe, S; Maehara, Y; Sakaguchi, Y; Sugimachi, K1
Fujita, K; Munakata, A1
Mitsuyama, M; Nomoto, K; Yokokura, T; Yoshikai, Y1
Adachi, S; Akaza, H; Ishitsuka, H; Kanazawa, K; Miwa, M; Nitta, K; Sekiguchi, F; Tokita, H1
Akazai, Y; Fuchimoto, S; Iwagaki, H; Matsubara, N; Orita, K; Shiiki, S; Watanabe, T1
Bando, Y; Furukawa, K; Iseki, T; Kawahito, M; Komi, N; Kunitomo, K; Miura, M; Morioka, K; Sasaki, K1
Hayashi, H; Hazama, S; Murakami, T; Oka, M; Suzuki, T1
Kawabata, N; Nakashima, T; Ohno, H; Yano, K1
Ban, Y; Ito, Y; Kawada, Y; Kuriyama, M; Maeda, S; Shinoda, I; Tada, K; Takahashi, Y; Takeuchi, T; Yamamoto, N1
Furusawa, M; Kakeji, Y; Maehara, Y; Sugimachi, K; Tomoda, H; Tsujitani, S; Watanabe, A1
Fukuoka, M; Kudoh, S; Kusunoki, Y; Masuda, N; Matsui, K; Negoro, S; Ryu, S; Sakai, N; Takada, M; Takifuji, S1
Camps, C; Godes, M; Soler, JJ1
Chen, JT; Fujimoto, I; Hamada, T; Hasumi, K; Hirai, Y; Nakayama, K; Shimizu, Y; Teshima, H; Yamauchi, K; Yokosuka, K1
Horiuchi, M; Kaneko, S; Komiyama, S; Miyake, H; Ogasawara, H; Sugita, M; Tsukuda, M1
Amemiya, A; Emoto, T; Fujii, M; Han, N; Itou, A; Iwasaki, T; Tsujimura, T; Yoshikawa, K1
Arai, K; Awane, Y; Kitamura, M; Miyashita, K1
Katsuki, Y; Nishimura, A; Tsuji, Y; Yasuda, T1
Fujita, M; Fujita, Y; Ota, J; Sakamoto, Y; Sugimoto, T; Taguchi, T1
Houjo, K; Kawano, N; Moriya, Y; Sugihara, K1
Hara, I; Kameyama, Y; Sakaki, Y; Tateishi, A; Yamada, N1
Fukatsu, H; Hirata, N; Honda, N; Muramatsu, T; Segawa, A; Senda, H; Yamada, Y1
Ishibiki, K; Kumai, K1
Griffiths, JR; Maxwell, RJ; Prior, MJ1
Imai, S; Morimoto, H; Nio, Y; Shiraishi, T; Tobe, T; Tseng, CC; Tsubono, M1
Hirose, S; Kito, M; Takeshima, S; Urakami, K; Yoshida, S1
Fujioka, T; Hasegawa, M; Ishikura, K; Koike, H; Kubo, T; Nomura, K; Okamoto, T; Tanji, S1
Haruyama, K; Hase, S; Ishizawa, T; Katsura, Y; Niwa, K; Sameshima, T; Shimazu, H; Yamada, K; Yoshimura, A1
Pedersen, H; Vestlev, PM1
Brusentsov, NA; Glazkova, TIu; Iavorskaia, NP; Iurchenko, NIa1
Cui, W; Wen, JQ1
Hisamatsu, K; Ihara, T; Kirimoto, K; Matsuda, M; Nanba, K; Okamoto, E; Suemitsu, H; Yamada, M1
Irie, G; Kamada, T; Matsuoka, Y; Shirato, H; Takamura, A; Tsuji, H; Tsujii, H1
Ikeguchi, S; Muto, K; Namba, M; Shida, S1
Asada, I; Furutani, M; Harada, T; Hayashi, S; Kitao, T; Matsushita, T; Shirosaki, H; Tanaka, T1
Hieda, S; Ishihara, M; Noguchi, M; Sawaguchi, K; Ueno, N; Yabushita, H1
Abe, O; Hattori, T; Kikuchi, K; Komi, N; Kondo, T; Kunii, Y; Nakajima, T; Nakazato, H; Taguchi, T; Tanabe, T1
Anai, H; Kido, Y; Korenaga, D; Kusumoto, H; Kusumoto, T; Maehara, Y; Okamura, T; Sakaguchi, Y; Sugimachi, K1
Barkanov, AI; Komov, DV; Roshchin, EM1
Inoue, K; Mitani, K; Morishita, Y; Yamashita, K1
Arima, S; Futami, K; Shimura, H; Toriya, H1
Hosoi, H; Kitagawa, M; Sinmyo, K; Susaki, H; Suwa, H; Yamaguchi, K1
Fujii, S; Fukushima, M; Shimamoto, Y; Shirasaka, T1
Imai, S; Nio, Y; Ohgaki, K; Shiraishi, T; Tobe, T1
Kimura, T; Kusama, S; Morioka, Y; Muto, T; Ogawa, N; Tomiyama, J1
Furusawa, M; Hara, Y; Kono, A1
Iwano, I; Kikuchi, Y; Kita, T; Kizawa, I; Kuki, E; Miyauchi, M; Oomori, K1
Ono, M1
Arima, S; Futami, K; Shimura, H; Yoshimura, S1
Akashi, A; Hashimoto, J; Kawashima, Y; Matsumura, A; Minami, M; Mizuta, T; Nakagawa, K; Nakahara, K; Ohno, K; Takeda, S1
Ono, T; Sawaki, S; Sudo, K; Tsukuda, M; Yanoma, S1
Aoki, H; Ishibashi, M; Itoh, S; Kadowaki, A; Kogure, H; Tagaya, N; Tajima, T; Tajima, Y; Tomita, T1
Hattori, T; Nakamura, T; Niimoto, M; Toge, T; Toi, M; Wada, T; Yamamoto, A1
Ando, J; Kosaka, A; Sumiyoshi, K1
Ahlgren, JD; Falchuk, SC; Macdonald, JS; Neefe, JR; Schein, PS; Smith, FP; Treat, J; Woolley, PV1
Nishida, M; Sekiguchi, I; Suzuki, M; Tamada, T3
Ito, Y; Matsuoka, S; Misawa, K; Nagafuchi, E; Nakajima, Y; Ogasawara, K; Sato, N; Uchino, J; Une, Y1
Fujii, M; Hosoda, H; Inuyama, Y; Kohno, N; Takaoka, T; Tanaka, J1
Suenaga, M1
Ito, T; Izumi, T; Kurihara, M; Sasaki, J1
Goto, S; Horiuchi, Y; Nagayo, T; Ohkita, T; Shimaji, T; Suga, S; Yokoyama, Y1
Akine, Y; Egawa, S; Hijikata, J; Kajiura, Y; Kitagawa, T; Ogino, T; Tsukiyama, I; Yamashita, K1
Koyama, H; Shiba, E1
Baba, H; Kunimoto, T; Nitta, K; Sasaki, T; Takeuchi, M; Tanaka, T; Uehara, N1
Wang, GT1
Kato, T; Ota, K1
Fujita, F; Fujita, M; Inaba, H; Sakamoto, Y; Shimozuma, K; Taguchi, T1
Fujii, S1
Eda, H; Fujimoto, K; Fukuda, H; Ishitsuka, H; Miwa, M1
Hattori, T; Hirabayashi, N; Kirihara, Y; Niimoto, M; Nishiyama, M; Nosoh, Y; Saeki, T; Takagami, S1
Hasegawa, H; Nakajima, Y; Obata, H; Ohnishi, K; Ohtsuki, T; Okazaki, N; Okuda, K; Tomimatsu, M1
Fuse, M; Kondo, H; Mori, K; Ohta, Y; Onji, M; Yamashita, Y1
Oguma, S; Ouchi, K; Owada, Y; Sakai, K; Sato, R; Sato, T1
Imai, Y; Kawata, S; Minami, Y; Miyoshi, S; Noda, S; Saitoh, R; Tamura, S; Tarui, S1
Inoue, S; Kato, H; Okada, Y; Takahashi, K; Yamanaka, A1
Hanaue, H; Horie, F; Kitano, Y; Kurosawa, T; Miyakawa, S; Nemoto, A; Shikata, J2
Aoki, N1
Fujiwara, K; Inoue, K; Kaneshige, E; Kobashi, Y; Kono, I; Sekiba, K; Tanimura, T1
Oiwa, T; Saito, H1
Dokiya, T; Hashimoto, S; Kunieda, E; Miyamoto, H; Shigematsu, N; Tominaga, J1
Furukawa, H; Iwanaga, T1
Kobayashi, H; Obata, K; Sahashi, M1
Bjerkeset, T; Fjøsne, HE1
Kimura, M; Koida, T; Sugihara, S1
Hoshi, A; Iigo, M; Kitagawa, H1
Hayakawa, M; Morise, K; Ohno, R; Saito, H1
Arima, S; Futami, K; Kinashi, M; Shigeta, M; Shimura, H1
Fujita, H; Ikuzawa, M; Kawai, Y; Matsuki, M; Muto, S; Nakajima, S; Ogawa, K; Shimamura, M; Togawa, M; Yoshikumi, C2
Nakamura, A; Ohkawa, T; Okamoto, Y1
Abe, Y; Kido, Y; Kobayashi, M; Mori, T; Naruko, M; Niwa, H; Ogawa, Y; Tane, S1
Kamiya, H; Nagai, S; Sakai, K; Sato, K1
Aota, M; Daitoh, N; Jinno, K; Nakayama, S; Yokomise, H1
Anai, H; Fukuchi, K; Kusumoto, H; Maehara, Y; Miyamoto, K; Sugimachi, K1
Maeda, T1
Burgess, M; Pasterz, R; Savaraj, N1
Kimoto, M; Nagano, H; Sano, K2
Ganina, KP; Zhero, SV1
Anai, H; Kusumoto, H; Maehara, Y; Masuda, H; Sugimachi, K1
Kimura, K; Seki, H; Takahashi, H1
Asagoe, T; Hanaue, H; Kitano, Y; Kurosawa, T; Miyakawa, S; Nemoto, A; Shikata, J; Takada, T; Yamamoto, H; Yasuda, H1
Asensio, F; Candel, M; Delgado, F; Garcia, J; Lledó, S; Redón, J; Roig, JV; Sanchez, A; Sanchis, C; Villar, A1
Konishi, R; Nakamura, J; Sasaki, H; Shibasaki, J1
Konami, T; Konishi, T; Pak, K; Takayama, H; Tomoyoshi, T1
Amano, T; Fujimoto, Y; Imada, T; Matsumoto, A; Noguchi, Y; Tamura, S; Yamamoto, Y1
Abe, T; Horiike, S; Inazawa, J; Misawa, S; Nishigaki, H; Okuda, T; Taniwaki, M; Tsuji, H; Yashige, H; Yokota, S1
Fujita, H; Furue, H; Hasegawa, K; Kurihara, M; Nakao, I; Niitani, H; Tsukagoshi, S1
Kamiwatari, M; Kosya, S; Nagata, Y; Shiokawa, H; Ueda, T; Yamada, E; Yamamoto, S1
Kanno, M; Katakura, R; Kitahara, M; Mori, T; Niizuma, H; Suzuki, J; Wada, T; Yoshimoto, T1
Aoki, Y; Fukunaga, H; Katsumi, M; Kawaguchi, T; Konishi, R; Oka, S; Takifuji, K; Tamaki, Y; Yukawa, H1
De Clercq, E; Hoshi, A; Iigo, M; Nakajima, Y1
Imai, S; Nio, Y; Ohgaki, K; Tobe, T1
Gunge, N; Iwamoto, S; Kimoto, M; Murei, T; Nagano, H; Sano, K; Seo, Y; Yamamoto, Y1
Fukuzumi, N; Ikeda, Y; Kaga, F; Kitajima, M; Kiuchi, T; Okada, N1
Honda, M; Hosoya, Y; Mukae, K; Murahashi, I; Takasaki, E1
Anai, H; Fukuchi, K; Kusumoto, H; Kusumoto, T; Maehara, Y; Miyamoto, K; Sugimachi, K1
Adachi, S; Ishida, M; Kanazawa, K; Misawa, Y; Takeuchi, S; Yoshiya, N; Yuzawa, H1
Ishizawa, T; Shimazu, H; Takao, S; Yamada, K1
Fujita, Y; Nishioka, B; Otsuji, E; Takahashi, T; Yamaguchi, T; Yamane, T1
Fujimoto, T; Ishida, T; Kurogoh, F; Ohyanagi, H; Okumura, S; Saitoh, Y; Shimada, Y; Tagashira, Y; Uchida, K; Yamamoto, M1
Andersen, E; Pedersen, H1
Anai, H; Kusumoto, H; Kusumoto, T; Maehara, Y; Sugimachi, K2
Hamada, J; Hosokawa, M; Kobayashi, H; Komatsumoto, M; Li, S; Okayasu, T; Takeichi, N; Tanabe, T1
Abe, M; Amano, T; Imada, T; Matsumoto, A; Tamura, S; Yamamoto, Y1
Baba, T; Furukohori, N; Itoh, T; Kawata, K; Kimura, T; Munakata, A; Saitoh, S; Sakata, Y; Suzuki, H; Tamura, Y1
Inoue, H; Kawada, S; Koide, S; Ogawa, J; Shohtsu, A1
Arima, S; Futami, K; Sakaida, R; Shigeta, M; Shinohara, T; Tateishi, S; Yoshimura, S1
Hattori, T; Jinushi, K; Kim, R; Kirihara, Y; Niimi, K; Niimoto, M; Nishiyama, M; Saeki, T; Takagami, S; Toge, T1
Kikuchi, K; Kunii, Y; Mori, Y; Nitta, A; Saitou, T; Takahashi, N1
Fukushi, G; Itoh, T; Kimura, M; Kimura, T; Kishibe, T; Saitoh, S; Sakata, Y; Suzuki, H; Tamura, Y; Tsushima, K1
Ito, T; Nehashi, Y; Sasaki, J; Sasaki, Y1
Peek, U1
Hashimoto, T; Iigima, N; Iwasaki, M; Kameya, S; Narita, M; Sato, M; Sou, M; Takeshita, T1
Eida, K; Fukuda, Y; Hirano, T; Ishii, T; Kotake, Y; Kusano, H; Nakagoe, T; Shimizu, T; Shimoyama, T; Tomita, M1
Hatano, T; Hayakawa, M; Igarashi, M; Kashiwabara, N; Koyama, Y; Miyazato, T; Osawa, A; Saito, S; Sato, K1
Alekseenko, AV; Fedorak, SS; Iftodiĭ, AG; Seniutovich, RV; Vasilov, VI1
Miki, H; Nakagawa, Y; Ogawa, N; Suzuki, H; Takahashi, M; Tominaga, M1
Fuchimoto, S; Iwagaki, H; Miyake, M; Orita, K; Shiiki, S1
Nakamura, K; Ozaki, H; Tajiri, H; Yoshimori, M1
Furue, H; Goto, Y; Kimura, T; Kondo, T; Nakao, I; Orita, K; Sato, S; Taguchi, T; Takino, T; Uchino, H1
Aogauchi, R; Ishii, N; Nakamura, K; Tsubota, N; Yamashita, C; Yoshikawa, K1
Hayashi, K; Kitamura, M; Kosaki, G; Takahashi, I; Tominaga, T1
Arai, Y; Endo, T; Kido, C; Ota, K; Suyama, K1
Iizuka, N; Machida, T; Masuda, F; Mori, Y; Nakada, J; Ohnishi, T; Suzuki, M1
Ichihashi, H; Ikenaga, T; Isomatsu, T; Kondo, T; Nakajima, T; Nakamura, T; Sakabe, T; Shiratori, T; Taguchi, T; Yamauchi, M1
Furue, H; Hattori, T; Itoh, I; Kimura, T; Kondo, T; Ogawa, N; Taguchi, T1
Byfield, JE; Floyd, RA; Frankel, SS; Griffiths, JC; Hornbeck, CL; Sharp, TR1
Kataba, Y; Kikuchi, H; Maruyama, Y; Namatame, K; Otani, Y; Watanabe, H; Yamanaka, T; Yoshida, K1
Hatta, M; Hirakawa, T; Kito, T; Kobari, T; Nakazato, H; Yamamura, Y; Yasue, M1
Aoki, S; Hirahara, K; Hirose, S; Hori, M; Kitagawa, M; Nakagawa, H; Nishimura, K1
Koyama, H; Nishizawa, Y; Shiba, E; Terasawa, T1
Sakata, Y; Yoshida, Y1
Kamiya, H; Nagai, S; Sakai, K; Sawada, T; Tsukasaki, K1
Hasegawa, H; Takada, T; Uchiyama, K; Yasuda, H1
Kimura, M; Koida, T1
Arai, T; Honda, M; Kanbe, K; Kaneko, K; Maeda, S; Mukae, K; Murahashi, I; Sakuma, H; Tabata, Y; Takasaki, E1
Ip, M; Lam, WK; So, SY; Yu, DY1
Nakazato, H; Ota, K; Yamamura, Y; Yasue, M1
Ogawa, T; Sakuda, M; Yoneda, T2
Segawa, T; Toide, K; Unemi, N1
Byfield, JE; Frankel, SS; Griffiths, JC; Hornbeck, CL; Sharp, TR1
Fujimoto, S; Higuchi, M; Kitsukawa, Y; Miyazaki, M; Okui, K1
Asakawa, H; Koyama, K; Otake, S; Otawa, H1
Kutsuna, T; Matsumoto, S; Nagai, K; Nomoto, S; Sugimoto, T; Yoshizaki, S1
Asano, M; Kitamura, O; Kogire, M; Matsumoto, M; Noda, H; Yamada, T; Yoshida, A1
Fujiwara, M; Futatsuki, K; Ishibashi, I; Izuno, O; Kanda, Y; Shimada, S; Suda, Y; Takayama, S; Takemori, Y; Takubo, K1
Abe, O; Akiyama, H; Hattori, T; Inokuchi, K; Inoue, K; Kondo, T; Muto, T; Nakajima, T; Taguchi, T; Usugane, M1
Hattori, Y; Horiuchi, M; Miyake, H; Murakami, T; Otake, H; Sawaki, S; Takahashi, H; Takeyama, I; Tamamushi, N; Yao, K1
Hirano, H; Kawai, Y; Nishiyama, M; Sugiyama, Y; Taniguchi, H; Uematsu, A; Yanase, H1
Ass, NIa; Borisov, VI; Mamontov, AS1
Kobayashi, T; Mishina, T; Miyakoda, K; Nakagawa, S; Nakao, M; Toyoda, K1
Hisazumi, H; Kanda, S; Katsumi, T; Kawaguchi, K; Mikawa, I; Misaki, T; Miyagi, T; Nakamura, T; Orito, M; Sakai, A1
Ohwada, M; Sekiguchi, I; Suzuki, M; Tamada, T1
Iwanaga, T; Koyama, H; Sasaki, Y; Shiba, E; Terasawa, T; Wada, A1
Ikeya, T; Ishikawa, H; Izuo, M; Kaneko, H; Miyamoto, Y; Seki, M; Takeshita, M; Tozuka, S; Usui, R1
Ishijima, B; Mizutani, T; Morimatsu, Y; Sato, J; Yasue, M1
Franz, G; Lietz, H1
Eckhardt, S1
Fujii, M; Hosoda, H; Inuyama, Y; Saito, S; Takaoka, T; Tanaka, J1
Drobník, J; Spacek, P; Wichterle, O1
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Hadfield, AF; Sartorelli, AC1
Kitazato, K; Toide, K; Unemi, N2
Borchard, F1
Furusawa, S; Monma, K; Sasaki, K; Takayanagi, G1
Fujiwara, K; Fujiwara, T; Hayakawa, I; Nakamura, S; Nakayama, H; Nemoto, S; Nomura, K; Sasaki, A; Sasaki, M; Tsuchida, T; Watanabe, E; Yanagibashi, K1
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Maurer-Schultze, B1
Kikuchi, S; Ohya, T1
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Gostishchev, VK; Khanin, AG; Khokhlov, AM1
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Kikuchi, K; Majima, S; Murakami, M1
Okuda, M; Sato, K; Teramoto, T; Uematsu, Y; Ushijima, Y; Yoshida, H1
Yamada, E1
Okabe, H; Takeda, S; Toko, T; Unemi, N; Yuasa, C1
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Nishida, T1
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Nakayama, T; Noguchi, S1
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Matsumoto, H; Mori, T; Takahashi, K; Yamaguchi, T; Yasutome, M1
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Schmoll, HJ1
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Fukushima, M; Nakagawa, F; Saito, H; Sakamoto, K; Sakata, M; Sakata, Y1
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Kato, K1
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Cheng, AL; Hsu, CH; Huang, CC; Lin, SD; Shao, YY1
Hasegawa, H; Hisa, A; Kitagawa, Y; Ohishi, T; Okabayashi, K; Watanabe, M1
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Kobunai, T; Nakagawa, F; Nukatsuka, M; Saito, H; Sakamoto, K; Shiraishi, K; Takechi, T; Uchida, J1
Kobayashi, M; Kodera, Y; Morita, S; Sakamoto, J; Shitara, K; Tsuburaya, A; Yamaguchi, K; Yoshida, K; Yoshikawa, T; Yoshino, S1
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Sakata, Y; Satoh, T1
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Hirashima, T; Imamura, F; Kawase, I; Kijima, T; Komuta, K; Kumanogoh, A; Minami, S; Ogata, Y; Okafuji, K; Shiroyama, T; Tachibana, I; Yamamoto, S1
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Grothey, A1
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Hirashima, Y; Shirao, K1
Higashida, M; Hirai, T; Kubota, H; Matsumoto, H; Murakami, H; Nakamura, M; Nakashima, H; Oka, Y; Okumura, H; Tsutsumi, K1
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Beijnen, JH; Cats, A; Deenen, MJ; Mandigers, CM; Schellens, JH; Soesan, M; Terpstra, WE1
Higashida, M; Hirai, T; Kawabe, Y; Kubota, H; Matsumoto, H; Murakami, H; Nakamura, M; Nakashima, H; Oka, Y; Okumura, H1
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Fukayama, M; Hata, K; Ishihara, S; Kawai, K; Kiyomatsu, T; Morikawa, T; Nozawa, H; Watanabe, T1
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Fujishiro, M; Fujita, KI; Hasegawa, C; Ikeda, K; Ishida, H; Iwabuchi, S; Kumazawa, T; Lee, XP; Matsuyama, T; Onda, H; Sakamaki, H; Sasaki, Y; Sato, K; Shiokawa, R; Yamada, M1
Cruz-Muñoz, W; Hileeto, D; Kerbel, RS; Man, S; Muñoz, R; Viloria-Petit, A; Wood, GA; Xu, P1
Cho, K; Cho, S; Gwon, MR; Kang, WY; Kim, BK; Kim, JG; Lee, HW; Ohk, B; Seong, SJ; Sung, YK; Yoon, YR1
Hata, T; Ito, S; Ito, Y; Kaneda, N; Kuriki, R; Misawa, K; Nakayama, K; Tatematsu, M1
Akashi, K; Ariyama, H; Baba, E; Isobe, T; Ito, M; Komoda, M; Kusaba, H; Kuwayama, M; Momosaki, S; Nakano, M; Oda, Y; Ohmura, H; Okada, C; Okumura, Y; Tanishima, S; Tsuchihashi, K; Uchino, K; Yamada, Y; Yamaguchi, K1
Marsch, AF; Shakhbazova, A1
Arita, T; Fujiwara, H; Imamura, T; Kishimoto, T; Kiuchi, J; Komatsu, S; Konishi, H; Kosuga, T; Kubota, T; Nishibeppu, K; Okamoto, K; Otsuji, E; Shiozaki, A1
Doi, S; Fujiwara, H; Kawamura, T; Mikami, R; Nakamoto, Y; Noda, M; Okumoto, T; Tokunaga, Y; Tomita, N1
Endo, I; Kumamoto, T; Matsuyama, R; Murakami, T; Sawada, Y; Tsuchiya, N; Yabushita, Y1
Ito, Y; Kobuchi, S; Matsumura, E; Sakaeda, T1
Huang, H; Jin, H; Lou, Q; Shah, RJ; Wang, J; Wang, Y; Yang, J; Zhang, X; Zhou, H1
Chan, LF; Kamei, Y; Miyakita, H; Ogimi, T; Okada, K; Sadahiro, S; Saito, G; Suzuki, T1
Ando, M; Kadowaki, S; Komori, A; Masuishi, T; Mitani, S; Muro, K; Narita, Y; Taniguchi, H; Ura, T1
Chen, X; Ding, H; Ding, J; Luo, D; Wang, L; Wei, Y; Xiong, Y; Yi, F; Zhang, W1
Hattori, N; Hayashi, M; Iwata, N; Kanda, M; Kodera, Y; Koike, M; Nakayama, G; Omae, K; Shimizu, D; Tanaka, C; Yamada, S1
Arnold, D; Blohmer, JU; Bokemeyer, C; Borner, M; Brucker, S; Burmeister, T; Cascorbi, I; de Wit, M; Decker, T; Dietz, A; Einsele, H; Eisterer, W; Folprecht, G; Hilbe, W; Hoffmann, J; Hofheinz, RD; Knauf, W; Köhne, CH; Kunzmann, V; Largiadèr, CR; Lorenzen, S; Lüftner, D; Moehler, M; Nöthen, MM; Pox, C; Reinacher-Schick, A; Scharl, A; Schlegelberger, B; Schwab, M; Seufferlein, T; Sinn, M; Stroth, M; Tamm, I; Trümper, L; Wilhelm, M; Wöll, E; Wörmann, B1
Cui, H; Dai, G; Deng, G; Guan, J; Lou, C; Yuan, J; Zhang, W; Zhang, Y; Zhou, A; Zhou, J1
Akiyama, F; Inaji, H; Kurosumi, M; Masuda, N; Ohashi, Y; Ohno, S; Ohsumi, S; Saji, S; Sato, N; Shimomura, A; Takao, S; Tokuda, Y; Tsuda, H; Watanabe, T1
Aoki, Y; Boku, N; Booka, E; Funakoshi, T; Hamamoto, Y; Imamura, CK; Kawakami, T; Kawakubo, H; Kitagawa, Y; Kitago, M; Mizukami, T; Takeuchi, H; Takeuchi, M; Tanigawara, Y; Wakuda, K1
Akagi, Y; Ando, K; Baba, H; Enomoto, M; Fujita, F; Ihara, K; Miwa, K; Mori, M; Mori, S; Nakayama, G; Oki, E; Saeki, H; Shimokawa, M; Tominaga, M1
Bm Claes, K; Borbath, I; Casneuf, V; Demey, W; Geboes, KP; Haufroid, V; Van den Eynde, M; Verheezen, Y; Verstraete, AG1
Endo, Y; Hirashita, T; Inomata, M; Itoh, H; Iwao, M; Iwashita, Y; Masuda, T; Shiraiwa, K; Suzuki, Y; Tada, K; Tanaka, R; Uchida, H1
Chang, PY; Chen, JH; Chen, PH; Chen, YC; Chen, YG; Chien, WC; Chung, CH; Dai, MS; Ho, CL; Hu, JM; Huang, TC; Lai, SW; Lee, CH; Wu, YY; Yang, SS; Yeh, RH1
Baba, H; Denda, T; Gamoh, M; Ishioka, C; Iwanaga, I; Kobayashi, Y; Komatsu, Y; Kotake, M; Morita, S; Nakamura, M; Ohori, H; Sakashita, A; Sato, A; Shimada, K; Takahashi, M; Takahashi, S; Takashima, A; Tsuda, M; Yamada, Y; Yamaguchi, T; Yuki, S1
Hara, K; Ide, M; Kuriyama, K; Nakazawa, N; Ogawa, H; Oyama, T; Saeki, H; Sakai, M; Sano, A; Shimoda, Y; Shirabe, K; Sohda, M; Ubukata, Y; Yokobori, T1
Agarwal, R; Grieb, BC1
Ishizawa, K; Mitsuboshi, S; Niimura, T; Sakamoto, Y; Yoshino, M; Zamami, Y1
Ye, Y; Zheng, S1
Abdelmoneim, M; Bustos-Villalobos, I; Ichinose, T; Kasuya, H; Kikumori, T; Kodera, Y; Matsumura, S; Miyajima, N; Morimoto, D; Mukoyama, N; Naoe, Y; Ragab Eissa, I; Shibata, M; Takeuchi, D; Tanaka, M; Tsunoda, N1
Akazawa, M; Narimatsu, H; Sasahara, Y; Takumoto, Y1
Arakawa, A; Ii, Y; Irie, T; Kawaguchi, M; Kawai, M; Kobari, A; Kojima, Y; Momose, H; Sakamoto, K; Sugimoto, K; Terao, Y; Tomiki, Y; Tsukamoto, R1
Ito, Y; Kobuchi, S; Nakamura, T; Okamura, M; Tsuda, M1
Abe, S; Emoto, S; Ishihara, S; Kawai, K; Matsuzaki, H; Murono, K; Nagai, Y; Nozawa, H; Oba, K; Sasaki, K; Shinagawa, T; Sonoda, H; Yamamoto, Y; Yokoyama, Y; Yoshioka, Y1
Agatsuma, N; Imamaki, H; Nishikawa, Y; Oguro, F; Oura, M1

Reviews

179 review(s) available for fluorouracil and tegafur

ArticleYear
[Chemotherapy of gastrointestinal tumors (review of the literature)].
    Onkologie, 1978, Volume: 1, Issue:6

    Topics: Ancitabine; Carcinoma, Hepatocellular; Colonic Neoplasms; Doxorubicin; Drug Therapy, Combination; Fluorouracil; Gastrointestinal Neoplasms; Humans; Immunotherapy; Intestinal Neoplasms; Intestine, Small; Liver Neoplasms; Mitomycins; Neoplasm Metastasis; Nitrosourea Compounds; Palliative Care; Pancreatic Neoplasms; Porfiromycin; Remission, Spontaneous; Stomach Neoplasms; Streptozocin; Tegafur

1978
A recent overview of chemotherapy for advanced stomach cancer in Japan.
    Antibiotics and chemotherapy, 1978, Volume: 24

    Topics: Antineoplastic Agents; Carbazilquinone; Chromomycins; Drug Therapy, Combination; Fluorouracil; Humans; Immunotherapy; Infusions, Intra-Arterial; Japan; Mitomycins; Neoplasm Metastasis; Prognosis; Stomach Neoplasms; Tegafur

1978
[Drug treatment of inoperable stomach cancer].
    Sovetskaia meditsina, 1976, Issue:9

    Topics: Administration, Oral; Drug Administration Schedule; Drug Evaluation; Fluorouracil; Humans; Injections, Intravenous; Stomach Neoplasms; Tegafur

1976
[Dose intensity in cancer chemotherapy in gastric cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Drug Administration Schedule; Fluorouracil; Humans; Methotrexate; Mitomycin; Mitomycins; Stomach Neoplasms; Suppositories; Tegafur

1990
[Chemotherapy of tumors of the gastrointestinal tract].
    Sovetskaia meditsina, 1985, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Digestive System Neoplasms; Doxorubicin; Fluorouracil; Humans; Lomustine; Mitomycin; Mitomycins; Tegafur

1985
Potentiation of antimetabolite action by alkylating agents.
    Advances in enzyme regulation, 1985, Volume: 24

    Topics: Alkylating Agents; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Colonic Neoplasms; Doxorubicin; Drug Synergism; Female; Fluorouracil; Humans; Mitomycin; Mitomycins; Nitrosourea Compounds; Pancreatic Neoplasms; Rectal Neoplasms; Stomach Neoplasms; Tegafur

1985
The pharmacology of prodrugs of 5-fluorouracil and 1-beta-D-arabinofuranosylcytosine.
    Advances in pharmacology and chemotherapy, 1984, Volume: 20

    Topics: Acylation; Ancitabine; Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Cytarabine; Floxuridine; Fluorouracil; Humans; Phospholipids; Pyrimidines; Steroids; Tegafur

1984
[The diffuse endocrine system and the carcinoids of the alimentary tract. Part I: Orthological aspects and common morphological features of the carcinoids (author's transl)].
    Zeitschrift fur Gastroenterologie, 1982, Volume: 20, Issue:4

    Topics: Adrenocorticotropic Hormone; Aged; Appendiceal Neoplasms; APUD Cells; Carcinoid Tumor; Carmustine; Cytoplasmic Granules; Digestive System; Doxorubicin; Endocrine Glands; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Ileal Neoplasms; Intestinal Polyps; Jejunal Neoplasms; Male; Middle Aged; Multiple Endocrine Neoplasia; Precancerous Conditions; Tegafur

1982
Effect of human renal and hepatic disease on the pharmacokinetics of anticancer drugs.
    Cancer treatment reviews, 1982, Volume: 9, Issue:2

    Topics: Antineoplastic Agents; Aspartic Acid; Bleomycin; Cisplatin; Cyclophosphamide; Doxorubicin; Fluorouracil; Gallium; Humans; Kidney Diseases; Kinetics; Liver Diseases; Metabolic Clearance Rate; Methotrexate; Phosphonoacetic Acid; Protein Binding; Tegafur

1982
Chemotherapy in alimentary tract malignomas.
    Hepato-gastroenterology, 1981, Volume: 28, Issue:5

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Carmustine; Colonic Neoplasms; Cytarabine; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Lomustine; Male; Methotrexate; Mitomycin; Mitomycins; Rectal Neoplasms; Semustine; Stomach Neoplasms; Streptozocin; Tegafur; Vincristine

1981
Treatment of cultured human colon carcinoma cells with fluorinated pyrimidines.
    Cancer, 1980, Mar-15, Volume: 45, Issue:5 Suppl

    Topics: Cell Line; Cell Survival; Colonic Neoplasms; Culture Media; Drug Evaluation, Preclinical; Fluorouracil; Humans; Tegafur; Thymidine; Uridine

1980
[Chemotherapy of stomach cancer].
    Voprosy onkologii, 1980, Volume: 26, Issue:5

    Topics: Alkylating Agents; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Biological Availability; Drug Evaluation; Drug Therapy, Combination; Fluorouracil; Humans; Mitomycins; Nitrosourea Compounds; Stomach Neoplasms; Tegafur; Time Factors

1980
The pharmacology of ftorafur (R, S-1-(tetrahydro-2-furanyl)-5-fluorouracil.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1981, Volume: 76

    Topics: Animals; Biotransformation; Fluorouracil; Humans; Kinetics; Neoplasms; Tegafur

1981
Studies of analogs of fluorinated pyrimidine in Japan.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1981, Volume: 76

    Topics: Animals; Antineoplastic Agents; Drug Evaluation, Preclinical; Drug Therapy, Combination; Fluorouracil; Humans; Japan; Neoplasms; Neoplasms, Experimental; Tegafur; Uracil

1981
[Metabolic modulation as a method in tumor chemotherapy].
    Die Pharmazie, 1982, Volume: 37, Issue:7

    Topics: Antineoplastic Agents; Cytarabine; Fluorouracil; Humans; Methotrexate; Neoplasms; Tegafur; Thymidine; Uracil

1982
[Combined chemotherapy with 5-FU+cis-platin or UFT+cisplatin].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1995, Volume: 22, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Colorectal Neoplasms; Drug Administration Routes; Drug Administration Schedule; Fluorouracil; Humans; Stomach Neoplasms; Tegafur; Uracil

1995
[Chemotherapy of scirrhous gastric cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:14

    Topics: Adenocarcinoma, Scirrhous; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Doxorubicin; Etoposide; Fluorouracil; Humans; Interferon alpha-2; Interferon-alpha; Leucovorin; Levoleucovorin; Mitomycin; Nimustine; Recombinant Proteins; Stomach Neoplasms; Tegafur; Uracil

1994
[Overview of clinical trials on adjuvant chemotherapy for curatively resected gastric cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21 Suppl 3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Clinical Trials as Topic; Clinical Trials, Phase III as Topic; Cytarabine; Fluorouracil; Gastrectomy; Humans; Mitomycin; Stomach Neoplasms; Tegafur

1994
[Development of fluorinated pyrimidines in Japan].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:1

    Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Deoxycytidine; Drug Combinations; Fluorodeoxyuridylate; Fluorouracil; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neoplasms; Neoplasms, Experimental; Oxonic Acid; Pyridines; Rats; Tegafur

1993
New anticancer agents in clinical development.
    Oncology (Williston Park, N.Y.), 1995, Volume: 9, Issue:12

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Deoxycytidine; Enzyme Inhibitors; Fluorouracil; Gemcitabine; Humans; Neoplasms; Polysaccharides, Bacterial; Prodrugs; Quinazolines; Tegafur; Thiophenes; Thymidylate Synthase; Uracil

1995
Intraarterial infusion chemotherapy for unresectable hepatic metastases from colorectal cancer.
    Gan to kagaku ryoho. Cancer & chemotherapy, 1996, Volume: 23, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Liver Neoplasms; Mitomycin; Survival Rate; Tegafur; Uracil

1996
Primary linitis plastica of the rectum: report of four cases and review of the literature.
    Surgery today, 1996, Volume: 26, Issue:11

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Disease-Free Survival; Female; Fluorouracil; Humans; Linitis Plastica; Male; Middle Aged; Mitomycins; Prognosis; Rectal Neoplasms; Tegafur; Time Factors; Uracil

1996
[Clinical use of platinum compounds and fluorinated pyrimidines for lung cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1996, Volume: 23, Issue:13

    Topics: Antineoplastic Agents; Carboplatin; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cisplatin; Drug Combinations; Fluorouracil; Humans; Lung Neoplasms; Tegafur; Uracil

1996
Modulation of 5-FU and its related compounds.
    Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24 Suppl 1

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Fluorouracil; Humans; Neoplasms; Pyridines; Tegafur; Uracil

1997
[Benefits of adjuvant chemotherapy for breast cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Drug Combinations; Female; Fluorouracil; Humans; Lymphatic Metastasis; Methotrexate; Mitomycin; Randomized Controlled Trials as Topic; Tamoxifen; Tegafur; Uracil

1997
Current and future directions in adjuvant combined-modality therapy of rectal cancer.
    Oncology (Williston Park, N.Y.), 1997, Volume: 11, Issue:9 Suppl 10

    Topics: Antidotes; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Drug Combinations; Fluorouracil; Forecasting; Humans; Leucovorin; Radiotherapy, Adjuvant; Randomized Controlled Trials as Topic; Rectal Neoplasms; Tegafur; Uracil

1997
[Chemoradiation for rectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:14

    Topics: Antineoplastic Combined Chemotherapy Protocols; Autonomic Pathways; Drug Administration Schedule; Fluorouracil; Humans; Nimustine; Radiotherapy Dosage; Rectal Neoplasms; Rectum; Tegafur

1997
[Invention of a tumor-selective 5-fluorouracil derivative named S-1 by biochemical modulation of 5-fluorouracil].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1998, Volume: 25, Issue:3

    Topics: Animals; Anorexia; Antimetabolites, Antineoplastic; Diarrhea; Dogs; Drug Combinations; Female; Fluorouracil; Immunologic Factors; Male; Mice; Mice, Nude; Oxonic Acid; Pyridines; Rats; Sarcoma, Yoshida; Tegafur; Vomiting

1998
UFT: biochemical modulation for 5-fluorouracil (5-FU).
    Chinese medical journal, 1997, Volume: 110, Issue:4

    Topics: Antineoplastic Agents; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase I as Topic; Drug Combinations; Fluorouracil; Humans; Lung Neoplasms; Neoplasms; Tegafur; Uracil

1997
New drugs in the treatment of colorectal carcinoma.
    Cancer, 1998, Aug-15, Volume: 83, Issue:4

    Topics: Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Tegafur; Thiophenes; Topotecan; Trimetrexate; Uracil

1998
Oral 5-FU alternatives for the treatment of head and neck cancer.
    Oncology (Williston Park, N.Y.), 1998, Volume: 12, Issue:10 Suppl 7

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Etoposide; Fluorouracil; Head and Neck Neoplasms; Humans; Hydroxyurea; Neoplasm Recurrence, Local; Tegafur; Uracil

1998
Oral 5-FU analogues in the treatment of breast cancer.
    Oncology (Williston Park, N.Y.), 1998, Volume: 12, Issue:10 Suppl 7

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Deoxycytidine; Enzyme Inhibitors; Female; Fluorouracil; Humans; Tegafur; Uracil

1998
Chemotherapy for gastric carcinoma: new and old options.
    Oncology (Williston Park, N.Y.), 1998, Volume: 12, Issue:10 Suppl 7

    Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Capecitabine; Deoxycytidine; Docetaxel; Drug Combinations; Enzyme Inhibitors; Etoposide; Fluorouracil; Humans; Infusions, Intravenous; Irinotecan; Oxonic Acid; Paclitaxel; Pyridines; Randomized Controlled Trials as Topic; Stomach Neoplasms; Taxoids; Tegafur; Uracil

1998
The oral fluorouracil prodrugs.
    Oncology (Williston Park, N.Y.), 1998, Volume: 12, Issue:10 Suppl 7

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Fluorouracil; Humans; Leucovorin; Oxonic Acid; Prodrugs; Pyridines; Tegafur; Uracil

1998
Oral fluoropyrimidines in the treatment of colorectal cancer.
    European journal of cancer (Oxford, England : 1990), 1998, Volume: 34, Issue:10

    Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Enzyme Inhibitors; Fluorouracil; Humans; Oxidoreductases; Pyridines; Tegafur; Uracil

1998
[Gastrointestinal cancer and oral anticancer agents].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1999, Volume: 26, Issue:3

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Camptothecin; Drug Combinations; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Irinotecan; Organoplatinum Compounds; Oxonic Acid; Prodrugs; Pyridines; Tegafur; Uracil

1999
[Combination therapy of continuous venous infusion (CVI) of 5-FU and low dose consecutive cisplatin (CDDP), and the new oral anti-cancer drug S-1 for advanced gastro-intestinal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1999, Volume: 26, Issue:4

    Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cell Cycle; Cisplatin; Drug Administration Schedule; Drug Combinations; Fluorouracil; Gastrointestinal Neoplasms; Humans; Infusions, Intravenous; Oxonic Acid; Pyridines; Rats; Tegafur

1999
[Oral fluoropyrimidines in oncology].
    Anales de la Real Academia Nacional de Medicina, 1998, Volume: 115, Issue:3

    Topics: Administration, Oral; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Clinical Trials as Topic; Combined Modality Therapy; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Male; Neoplasm Recurrence, Local; Neoplasms; Tegafur; Time Factors; Uracil

1998
Fluoropyrimidines: a critical evaluation.
    Oncology, 1999, Volume: 57 Suppl 1

    Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Leucovorin; Oxonic Acid; Pyridines; Tegafur; Uracil

1999
Clinical implications of dihydropyrimidine dehydrogenase inhibition.
    Oncology (Williston Park, N.Y.), 1999, Volume: 13, Issue:7 Suppl 3

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biological Availability; Dihydrouracil Dehydrogenase (NADP); Drug Evaluation; Enzyme Inhibitors; Fluorouracil; Humans; Neoplasms; Oxidoreductases; Tegafur; Uracil

1999
The oral fluoropyrimidines in cancer chemotherapy.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:9

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Fluorouracil; Humans; Prodrugs; Tegafur

1999
A review of the pharmacology and clinical activity of new chemotherapy agents for the treatment of colorectal cancer.
    British journal of clinical pharmacology, 1999, Volume: 48, Issue:3

    Topics: Antineoplastic Agents; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Glutamates; Guanine; Humans; Pemetrexed; Platinum Compounds; Pyridines; Quinazolines; Tegafur; Thiophenes; Uracil

1999
Oral fluoropyrimidines: a closer look at their toxicities.
    American journal of clinical oncology, 1999, Volume: 22, Issue:5

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Fluorouracil; Humans; Tegafur; Uracil

1999
The role of UFT in combined-modality therapy.
    Oncology (Williston Park, N.Y.), 1999, Volume: 13, Issue:10 Suppl 5

    Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Combined Modality Therapy; Fluorouracil; Gastrointestinal Neoplasms; Humans; Infusions, Intravenous; Leucovorin; Neoplasms; Radiation-Sensitizing Agents; Tegafur; Uracil

1999
[Combination chemotherapy with 5-FU and low-dose CDDP for urogenital tumors].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1999, Volume: 26, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cisplatin; Combined Modality Therapy; Female; Fluorouracil; Humans; Infusions, Intravenous; Interferon-alpha; Kidney Neoplasms; Male; Tegafur; Uracil; Urinary Bladder Neoplasms

1999
New drugs in therapy of colorectal cancer: preclinical studies.
    Seminars in oncology, 1999, Volume: 26, Issue:6

    Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fluorouracil; Folic Acid Antagonists; Humans; Oxidoreductases; Prodrugs; Quinazolines; Tegafur; Thiophenes; Thymidine Phosphorylase; Thymidylate Synthase; Uracil

1999
Oral fluoropoyrimidines.
    Seminars in oncology, 1999, Volume: 26, Issue:6

    Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Enzyme Inhibitors; Fluorouracil; Folic Acid Antagonists; Humans; Leucovorin; Oxidoreductases; Oxonic Acid; Prodrugs; Pyridines; Tegafur; Uracil

1999
Oxaliplatin: a new therapeutic option in colorectal cancer.
    Seminars in oncology, 1999, Volume: 26, Issue:6

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Drug Synergism; Fluorouracil; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Tegafur; Thiophenes; Uracil

1999
[New drugs in gastrointestinal oncology. Current status and future directions].
    Gastroenterologie clinique et biologique, 1999, Volume: 23, Issue:11

    Topics: Antineoplastic Agents; Camptothecin; Capecitabine; Deoxycytidine; Docetaxel; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Gemcitabine; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Quinazolines; Taxoids; Tegafur; Thiophenes; Vinblastine; Vinorelbine

1999
Tegafur/uracil + calcium folinate in colorectal cancer: double modulation of fluorouracil.
    Drugs, 1999, Volume: 58 Suppl 3

    Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colorectal Neoplasms; Drug Combinations; Fluorouracil; Humans; Leucovorin; Tegafur; Uracil

1999
Oral therapy for colorectal cancer: how to choose.
    Oncology (Williston Park, N.Y.), 2000, Volume: 14, Issue:6

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Biological Availability; Capecitabine; Colorectal Neoplasms; Decision Making; Deoxycytidine; Enzyme Inhibitors; Fluorouracil; Humans; Leucovorin; Tegafur; Uracil

2000
Conceptual changes in cancer chemotherapy--biochemical modulation of 5-FU from bench to clinic.
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27 Suppl 2

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Fluorouracil; Humans; Neoplasms; Tegafur

2000
Preoperative therapy for local-regional gastric cancer: rationale and review of trials.
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27 Suppl 2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Doxorubicin; Etoposide; Fluorouracil; Humans; Methotrexate; Mitomycin; Preoperative Care; Stomach Neoplasms; Tegafur; Uracil

2000
[Conceptual changes in cancer chemotherapy--biochemical modulation of 5-FU].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:6

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colonic Neoplasms; Drug Administration Schedule; Drug Combinations; Esophageal Neoplasms; Fluorouracil; Humans; Infusions, Intravenous; Oxonic Acid; Pancreatic Neoplasms; Pyridines; Rectal Neoplasms; Tegafur

2000
Oral fluoropyrimidines in the treatment of colorectal cancer.
    Clinical oncology (Royal College of Radiologists (Great Britain)), 2000, Volume: 12, Issue:4

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Fluorouracil; Humans; Pyrimidines; Tegafur; Uracil

2000
Progress in colorectal cancer chemotherapy: how far have we come, how far to go?
    Drugs & aging, 2000, Volume: 17, Issue:3

    Topics: Camptothecin; Capecitabine; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Immunotherapy; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Tegafur; Thiophenes

2000
Mechanism of action of fluoropyrimidines: relevance to the new developments in colorectal cancer chemotherapy.
    Seminars in oncology, 2000, Volume: 27, Issue:5 Suppl 10

    Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Fluorouracil; Folic Acid Antagonists; Humans; Leucovorin; Prodrugs; Tegafur; Uracil

2000
Oral fluoropyrimidines in colorectal cancer.
    Seminars in oncology, 2000, Volume: 27, Issue:5 Suppl 10

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Leucovorin; Oxonic Acid; Pyridines; Tegafur; Uracil

2000
Conceptual changes in cancer chemotherapy: from an oral fluoropyrimidine prodrug, UFT, to a novel oral fluoropyrimidine prodrug, S-1, and low-dose FP therapy in Japan.
    Investigational new drugs, 2000, Volume: 18, Issue:4

    Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Combinations; Drug Synergism; Drug Therapy; Fluorouracil; Humans; Oxonic Acid; Prodrugs; Pyridines; Tegafur; Uracil

2000
UFT: mechanism of drug action.
    Oncology (Williston Park, N.Y.), 2000, Volume: 14, Issue:10 Suppl 9

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Drug Resistance, Neoplasm; Drug Therapy, Combination; Fluorouracil; Humans; Tegafur; Thymidylate Synthase; Uracil

2000
Oral DPD-inhibitory fluoropyrimidine drugs.
    Oncology (Williston Park, N.Y.), 2000, Volume: 14, Issue:10 Suppl 9

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biological Availability; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Drug Resistance, Neoplasm; Fluorouracil; Humans; Leucovorin; Oxidoreductases; Oxonic Acid; Pyridines; Tegafur; Uracil

2000
[Current status and problem of adjuvant chemotherapy for curatively resected gastric cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:13

    Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Cyclophosphamide; Drug Administration Schedule; Fluorouracil; Gastrectomy; Humans; Melphalan; Meta-Analysis as Topic; Randomized Controlled Trials as Topic; Semustine; Stomach Neoplasms; Tegafur; Uracil

2000
[Latest progress on chemotherapy for advanced gastric cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:13

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Docetaxel; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Irinotecan; Oxonic Acid; Paclitaxel; Pyridines; Randomized Controlled Trials as Topic; Stomach Neoplasms; Survival Rate; Taxoids; Tegafur

2000
Oral fluoropyrimidines in cancer treatment.
    Cancer investigation, 2000, Volume: 18, Issue:8

    Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Head and Neck Neoplasms; Humans; Lung Neoplasms; Neoplasms; Pyridines; Stomach Neoplasms; Tegafur; Uracil

2000
[Fluorinated pyrimidines in oral treatment of advanced colorectal cancer].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2000, Sep-30, Volume: 120, Issue:23

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Enzyme Inhibitors; Fluorouracil; Humans; Leucovorin; Oxidoreductases; Prodrugs; Pyrimidines; Tegafur; Uracil

2000
Novel oral chemotherapy agents.
    Current oncology reports, 2000, Volume: 2, Issue:1

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Dacarbazine; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Neoplasms; Tegafur; Temozolomide; Uracil

2000
[Progress in chemotherapy for colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:14

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Cisplatin; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Irinotecan; Leucovorin; Oxonic Acid; Pyridines; Tegafur

2000
[Recent advances is surgical adjuvant chemotherapy for colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:14

    Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Drug Administration Schedule; Fluorouracil; Humans; Levamisole; Mitomycin; Randomized Controlled Trials as Topic; Semustine; Survival Rate; Tegafur; Uracil; Vincristine

2000
Colorectal cancer: chemotherapy treatment overview.
    Oncology (Williston Park, N.Y.), 2000, Volume: 14, Issue:12 Suppl 1

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Leucovorin; Organoplatinum Compounds; Oxaliplatin; Randomized Controlled Trials as Topic; Tegafur; Treatment Outcome; Uracil

2000
Other fluorinated pyrimidines in the treatment of solid tumors.
    Oncology (Williston Park, N.Y.), 2001, Volume: 15, Issue:1 Suppl 2

    Topics: Antimetabolites, Antineoplastic; Clinical Trials as Topic; Drug Combinations; Fluorouracil; Humans; Neoplasms; Oxonic Acid; Pyridines; Tegafur

2001
The oral fluorinated pyrimidines.
    Investigational new drugs, 2001, Volume: 19, Issue:1

    Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Biological Availability; Biotransformation; Capecitabine; Clinical Trials as Topic; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Enzyme Inhibitors; Fluorouracil; Humans; Neoplasms; Oxidoreductases; Prodrugs; Tegafur; Uracil

2001
Integrating the oral fluoropyrimidines into the management of advanced colorectal cancer.
    European journal of cancer (Oxford, England : 1990), 2001, Volume: 37, Issue:7

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Leucovorin; Pyrimidines; Quinazolines; Tegafur; Thiophenes; Uracil

2001
[5-fluorouracil and dihydropyrimidine dehydrogenase].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2001, Volume: 28, Issue:4

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Fluorouracil; Humans; Neoplasms; Oxidoreductases; Oxonic Acid; Pyridines; Tegafur; Uracil

2001
Adjuvant chemotherapy after resection of hepatocellular carcinoma causes deterioration of long-term prognosis in cirrhotic patients: metaanalysis of three randomized controlled trials.
    Cancer, 2001, Jun-15, Volume: 91, Issue:12

    Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Carcinoma, Hepatocellular; Chemotherapy, Adjuvant; Combined Modality Therapy; Drug Administration Schedule; Drug Tolerance; Epirubicin; Female; Fluorouracil; Hepatectomy; Humans; Liver Cirrhosis; Liver Neoplasms; Male; Multivariate Analysis; Neoplasm Recurrence, Local; Prognosis; Survival Rate; Tegafur; Treatment Outcome

2001
New options for outpatient chemotherapy--the role of oral fluoropyrimidines.
    Cancer treatment reviews, 2001, Volume: 27, Issue:4

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Enzyme Inhibitors; Fluorouracil; Humans; Outpatients; Tegafur; Uracil

2001
Oral uracil-tegafur: an alternative to intravenous 5-fluorouracil?
    Expert opinion on pharmacotherapy, 2001, Volume: 2, Issue:9

    Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Clinical Trials as Topic; Fluorouracil; Humans; Injections, Intravenous; Tegafur; Uracil

2001
Answering patients' needs: oral alternatives to intravenous therapy.
    The oncologist, 2001, Volume: 6 Suppl 4

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Capecitabine; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Infusions, Intravenous; Patient Satisfaction; Quality of Life; Tegafur; Uracil

2001
Nonsurgical treatment of hepatocellular carcinoma.
    Seminars in oncology, 2001, Volume: 28, Issue:5

    Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Capecitabine; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Cryosurgery; Deoxycytidine; Drug Combinations; Ethanol; Fluorouracil; Humans; Hyperthermia, Induced; Infusions, Intra-Arterial; Injections, Intralesional; Interferons; Liver Cirrhosis; Liver Neoplasms; Octreotide; Radiopharmaceuticals; Radiotherapy Dosage; Tamoxifen; Tegafur; Uracil

2001
[New therapeutic options in chemotherapy of advanced colorectal cancer].
    Medizinische Klinik (Munich, Germany : 1983), 2001, Oct-15, Volume: 96, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Carcinoma; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Disease-Free Survival; Fluorouracil; Humans; Irinotecan; Leucovorin; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Tegafur; Thiophenes; Uracil

2001
New therapies, new directions: advances in the systemic treatment of metastatic colorectal cancer.
    The Lancet. Oncology, 2001, Volume: 2, Issue:5

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Fluorouracil; Forecasting; Humans; Irinotecan; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Tegafur; Thiophenes; Trimetrexate; Uracil

2001
[Oral fluoropyrimidines registered for the treatment of metastatic colorectal carcinoma: a possible gain].
    Nederlands tijdschrift voor geneeskunde, 2002, Jun-15, Volume: 146, Issue:24

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Leucovorin; Neoplasm Metastasis; Pyrimidines; Tegafur; Uracil

2002
[The principles of cancer treatment--changes in chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:7

    Topics: ADP Ribose Transferases; Animals; Antineoplastic Agents; Benzamides; Cisplatin; Drug Combinations; Fluorouracil; Genes, ras; Humans; Imatinib Mesylate; Insect Proteins; Lung Neoplasms; Mice; Neoplasms; Neoplastic Syndromes, Hereditary; Oxonic Acid; Piperazines; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Signal Transduction; Tegafur; Tumor Cells, Cultured

2002
Clinical studies of three oral prodrugs of 5-fluorouracil (capecitabine, UFT, S-1): a review.
    The oncologist, 2002, Volume: 7, Issue:4

    Topics: Administration, Oral; Antineoplastic Agents; Capecitabine; Deoxycytidine; Fluorouracil; Humans; Neoplasms; Prodrugs; Pyridines; Tegafur; Treatment Outcome; Uracil

2002
Oral fluoropyrimidine treatment of colorectal cancer.
    Clinical colorectal cancer, 2001, Volume: 1, Issue:2

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Clinical Trials as Topic; Colorectal Neoplasms; Cost-Benefit Analysis; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Patient Compliance; Prodrugs; Pyridines; Tegafur; Treatment Outcome

2001
[Recent advance in adjuvant therapy for breast cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:13

    Topics: Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Clinical Trials as Topic; Female; Fluorouracil; Humans; Lymphatic Metastasis; Mastectomy; Methotrexate; Neoplasm Recurrence, Local; Prognosis; Survival Rate; Tamoxifen; Tegafur; Uracil

2002
[Progress in postoperative adjuvant chemotherapy in gastric cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:13

    Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cytarabine; Drug Administration Schedule; Fluorouracil; Gastrectomy; Humans; Lymphatic Metastasis; Meta-Analysis as Topic; Mitomycin; Stomach Neoplasms; Survival Analysis; Tegafur; Treatment Outcome

2002
[Progress in adjuvant therapy for colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:13

    Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Drug Administration Schedule; Fluorouracil; Humans; Leucovorin; Mitomycin; Radiotherapy, Adjuvant; Rectal Neoplasms; Tegafur; Uracil

2002
[Weekly administration of paclitaxel with a short course of premedication for advanced or recurrent gastric cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:1

    Topics: Aged; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasm Recurrence, Local; Oxonic Acid; Paclitaxel; Premedication; Pyridines; Stomach Neoplasms; Tegafur

2003
Palliative treatment of patients with colorectal cancer.
    Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society, 2003, Volume: 92, Issue:1

    Topics: Antimetabolites, Antineoplastic; Camptothecin; Colorectal Neoplasms; Disease Progression; Enzyme Inhibitors; Fluorouracil; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Palliative Care; Quinazolines; Survival Analysis; Tegafur; Thiophenes; Thymidylate Synthase; Topoisomerase I Inhibitors; Treatment Outcome; Uracil

2003
S-1 in gastric cancer: a comprehensive review.
    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2003, Volume: 6 Suppl 1

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Clinical Trials as Topic; Drug Combinations; Fluorouracil; Humans; Oxonic Acid; Pyridines; Quality of Life; Stomach Neoplasms; Tegafur; Treatment Outcome

2003
Current topics of S-1 at the 74th Japanese Gastric Cancer Congress.
    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2003, Volume: 6 Suppl 1

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Clinical Trials, Phase II as Topic; Drug Combinations; Fluorouracil; Humans; Japan; Oxonic Acid; Pyridines; Stomach Neoplasms; Tegafur

2003
Practical considerations in the use of oral fluoropyrimidines.
    Seminars in oncology, 2003, Volume: 30, Issue:3 Suppl 6

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Capecitabine; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Oxonic Acid; Prodrugs; Pyridines; Tegafur; Uracil

2003
[Oral fluoropyrimidines in the treatment of colorectal carcinoma].
    Deutsche medizinische Wochenschrift (1946), 2003, Jun-13, Volume: 128 Suppl 2

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Prodrugs; Tegafur; Uracil

2003
[Recent advances in chemotherapy for digestive cancers with special references to gastric and colonic cancers].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2003, Volume: 100, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Colonic Neoplasms; Docetaxel; Drug Administration Schedule; Drug Combinations; Drug Delivery Systems; Fluorouracil; Humans; Irinotecan; Oxonic Acid; Paclitaxel; Pyridines; Stomach Neoplasms; Taxoids; Tegafur

2003
[Controversial issues in chemotherapy for inoperable gastric cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Drug Combinations; Fluorouracil; Humans; Irinotecan; Oxonic Acid; Pyridines; Stomach Neoplasms; Survival Rate; Tegafur

2003
[Controversy of treatment for advanced colorectal cancer--intermedisine].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Irinotecan; Leucovorin; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Pyridines; Tegafur

2003
[Chemotherapy for colon cancer].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colonic Neoplasms; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Leucovorin; Organoplatinum Compounds; Oxaliplatin; Randomized Controlled Trials as Topic; Tegafur; Treatment Outcome; Uracil

2003
[Intravenous continuous infusion of fluorouracil for treatment of metastatic colorectal cancer].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 7

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Infusions, Intravenous; Oxonic Acid; Prognosis; Pyridines; Tegafur; Thymidylate Synthase; Uracil

2003
[Effect of systemic chemotherapy by 5-FU with low dose CDDP (in the hospital) and UFT with low dose CDDP (in outpatient clinic) in unresectable recurrent colorectal cancer].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 7

    Topics: Ambulatory Care Facilities; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colorectal Neoplasms; Fluorouracil; Home Care Services, Hospital-Based; Hospitals; Humans; Neoplasm Recurrence, Local; Prognosis; Tegafur; Uracil

2003
[Present status of chemotherapy for colorectal cancer in countries outside of Japan].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 7

    Topics: Administration, Oral; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Cetuximab; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Evidence-Based Medicine; Fluorouracil; Humans; Irinotecan; Japan; Leucovorin; Neoplasm Recurrence, Local; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Prognosis; Pyridines; Tegafur; United States; Uracil

2003
Clinical and cost-effectiveness of capecitabine and tegafur with uracil for the treatment of metastatic colorectal cancer: systematic review and economic evaluation.
    Health technology assessment (Winchester, England), 2003, Volume: 7, Issue:32

    Topics: Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Cost-Benefit Analysis; Deoxycytidine; Drug Therapy, Combination; Fluorouracil; Humans; Neoplasm Metastasis; Tegafur; United Kingdom; Uracil

2003
[Chemotherapy for colorectal carcinoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Prospective Studies; Randomized Controlled Trials as Topic; Tegafur; Uracil

2003
New developments in systemic chemotherapy in advanced colorectal cancer.
    Scandinavian journal of gastroenterology. Supplement, 2003, Issue:239

    Topics: Administration, Oral; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Capecitabine; Cetuximab; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Infusions, Intravenous; Irinotecan; Neoplasm Metastasis; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Tegafur; Thiophenes; Uracil

2003
Efficacy of oral adjuvant therapy after resection of colorectal cancer: 5-year results from three randomized trials.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Feb-01, Volume: 22, Issue:3

    Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Female; Fluorouracil; Humans; Male; Maximum Tolerated Dose; Mitomycin; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Randomized Controlled Trials as Topic; Rectal Neoplasms; Survival Rate; Tegafur

2004
The role of new agents in the treatment of colorectal cancer.
    Oncology, 2004, Volume: 66, Issue:1

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Cetuximab; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Randomized Controlled Trials as Topic; Survival Analysis; Tegafur; Treatment Outcome; Uracil

2004
[Oral 5-FU and digestive cancers].
    Gastroenterologie clinique et biologique, 2004, Volume: 28, Issue:3

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Fluorouracil; Gastrointestinal Neoplasms; Humans; Tegafur

2004
Comparative pharmacology of oral fluoropyrimidines: a focus on pharmacokinetics, pharmacodynamics and pharmacomodulation.
    British journal of cancer, 2004, Aug-16, Volume: 91, Issue:4

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Capecitabine; Deoxycytidine; Fluorouracil; Humans; Neoplasms; Prodrugs; Pyrimidinones; Tegafur; Uracil

2004
Thymidylate synthase expression and prognosis of patients with gastrointestinal cancers receiving adjuvant chemotherapy: a review.
    Langenbeck's archives of surgery, 2004, Volume: 389, Issue:5

    Topics: Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Clinical Trials as Topic; Combined Modality Therapy; Drug Resistance, Neoplasm; Fluorouracil; Gastrointestinal Neoplasms; Humans; Immunoblotting; Immunohistochemistry; Meta-Analysis as Topic; Neoplasm Recurrence, Local; Palliative Care; Pancreatic Neoplasms; Prognosis; RNA, Messenger; Survival Analysis; Tegafur; Thymidylate Synthase; Treatment Outcome

2004
Thymidylate synthase: a critical target in cancer therapy?
    Frontiers in bioscience : a journal and virtual library, 2004, Sep-01, Volume: 9

    Topics: Animals; Antineoplastic Agents; Apoptosis; Capecitabine; Cell Cycle; Cell Proliferation; Clinical Trials as Topic; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Leucovorin; Neoplasms; Oxonic Acid; Prodrugs; RNA, Messenger; Tegafur; Thymidylate Synthase

2004
[Recent progress in chemotherapy for hepatocellular carcinoma].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2004, Aug-10, Volume: 93, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Chemotherapy, Adjuvant; Chemotherapy, Cancer, Regional Perfusion; Cisplatin; Disease Progression; Doxorubicin; Drug Interactions; Embolization, Therapeutic; Fluorouracil; Hepatectomy; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Interferon-alpha; Liver Neoplasms; Organoplatinum Compounds; Oxaliplatin; Tamoxifen; Tegafur; Uracil

2004
[Advances in palliative and adjuvant chemotherapy of colon cancer].
    Deutsche medizinische Wochenschrift (1946), 2004, Oct-01, Volume: 129, Issue:40

    Topics: Antineoplastic Agents; Camptothecin; Capecitabine; Chemotherapy, Adjuvant; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Leucovorin; Levamisole; Organoplatinum Compounds; Oxaliplatin; Palliative Care; Tegafur; Uracil

2004
[Effectiveness of chemoradiotherapy for three cases of squamous cell anal carcinoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:11

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Female; Floxuridine; Fluorouracil; Humans; Lymphatic Metastasis; Middle Aged; Radiotherapy, Adjuvant; Tegafur; Uracil

2004
[CPT-11 combined chemotherapy for metastatic gastric cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:12

    Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Docetaxel; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Irinotecan; Leucovorin; Mitomycin; Oxonic Acid; Pyridines; Stomach Neoplasms; Taxoids; Tegafur

2004
[Current combination chemotherapy containing paclitaxel for advanced, recurrent gastric cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Drug Combinations; Floxuridine; Fluorouracil; Humans; Oxonic Acid; Paclitaxel; Pyridines; Quality of Life; Stomach Neoplasms; Tegafur

2004
[Second-line chemotherapy for advanced colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Irinotecan; Leucovorin; Quality of Life; Survival Rate; Tegafur; Uracil

2005
Commentary on Wang et al., "Pre-operative chemotherapy with oral tegafur-uracil and leucovorin for rectal cancer" (J Surg Oncol 89: 256-263).
    Journal of surgical oncology, 2005, May-01, Volume: 90, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase II as Topic; Combined Modality Therapy; Disease-Free Survival; Drug Combinations; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Preoperative Care; Rectal Neoplasms; Survival Rate; Tegafur; Uracil

2005
[5 -fluoropyrimidines for treatment of biliary tract cancers].
    Nihon rinsho. Japanese journal of clinical medicine, 2006, Volume: 64 Suppl 1

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biliary Tract Neoplasms; Capecitabine; Clinical Trials as Topic; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Oxonic Acid; Pyridines; Pyrimidines; Tegafur; Uracil

2006
Chemotherapy for colorectal cancer.
    Digestive surgery, 2005, Volume: 22, Issue:6

    Topics: Antimetabolites, Antineoplastic; Camptothecin; Capecitabine; Chemotherapy, Adjuvant; Colorectal Neoplasms; Deoxycytidine; Drug Therapy, Combination; Fluorouracil; Humans; Irinotecan; Leucovorin; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Survival Rate; Tegafur; Uracil; Vitamin B Complex

2005
[Adjuvant chemotherapy for colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Drug Combinations; Evidence-Based Medicine; Fluorouracil; Guidelines as Topic; Humans; Leucovorin; Lymph Node Excision; Neoplasm Staging; Survival Rate; Tegafur; Uracil

2006
The clinical and economic benefits of capecitabine and tegafur with uracil in metastatic colorectal cancer.
    British journal of cancer, 2006, Jul-03, Volume: 95, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Cost-Benefit Analysis; Deoxycytidine; Fluorouracil; Humans; Meta-Analysis as Topic; Randomized Controlled Trials as Topic; State Medicine; Tegafur; Treatment Outcome; United Kingdom; Uracil

2006
[Current evidence of irinotecan combination chemotherapy with TS-1 in patients with advanced colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Colorectal Neoplasms; Drug Administration Schedule; Drug Combinations; Evidence-Based Medicine; Fluorouracil; Humans; Irinotecan; Leucovorin; Neoplasm Recurrence, Local; Oxonic Acid; Survival Rate; Tegafur

2006
[Adjuvant treatment of colorectal cancer].
    Bulletin du cancer, 2006, Volume: 93, Issue:7

    Topics: Age Factors; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Camptothecin; Capecitabine; Chemotherapy, Adjuvant; Colonic Neoplasms; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Irinotecan; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Prognosis; Tegafur; Uracil

2006
[Timeline from discovery of 5-FU to development of an oral anticancer agent S-1 and its drug concept].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33 Suppl 1

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Drug Administration Schedule; Drug Combinations; Drug Synergism; Fluorouracil; Humans; Neoplasms; Oxonic Acid; Pharmaceutical Preparations; Prodrugs; Tegafur

2006
[Pharmacokinetics of S-1].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33 Suppl 1

    Topics: Administration, Oral; Adult; Aged; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Female; Fluorouracil; Humans; Kidney; Male; Middle Aged; Neoplasms; Oxonic Acid; Rats; Tegafur; Uracil

2006
[S-1 as a single agent for colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33 Suppl 1

    Topics: Administration, Oral; Anorexia; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Clinical Trials, Phase II as Topic; Colorectal Neoplasms; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Irinotecan; Leukopenia; Neutropenia; Oxonic Acid; Survival Rate; Tegafur

2006
[Clinical efficacy of administration with S-1 alone for head and neck carcinoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33 Suppl 1

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Clinical Trials, Phase II as Topic; Drug Combinations; Fluorouracil; Head and Neck Neoplasms; Humans; Oxonic Acid; Tegafur; Uracil

2006
[Chemotherapy in advanced gastric cancer--to ensure timely and appropriate switch to subsequent treatment options].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Clinical Trials, Phase III as Topic; Docetaxel; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Irinotecan; Leucovorin; Methotrexate; Oxonic Acid; Paclitaxel; Stomach Neoplasms; Survival Rate; Taxoids; Tegafur

2007
[Clinical development of chemotherapy for advanced gastric cancer].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2007, Volume: 104, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Cisplatin; Clinical Trials, Phase III as Topic; Docetaxel; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Irinotecan; Neoplasm Staging; Oxonic Acid; Stomach Neoplasms; Taxoids; Tegafur

2007
[Standard chemotherapy for colonic neoplasms].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2007, Feb-10, Volume: 96, Issue:2

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Fluorouracil; Humans; Irinotecan; Leucovorin; Organoplatinum Compounds; Oxaliplatin; Randomized Controlled Trials as Topic; Tegafur; Uracil

2007
Chemotherapy of advanced gastric cancer.
    Cancer treatment reviews, 2007, Volume: 33, Issue:4

    Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Clinical Trials as Topic; Deoxycytidine; Docetaxel; Drug Combinations; Fluorouracil; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Stomach Neoplasms; Taxoids; Tegafur; Uracil

2007
Is there an optimal neoadjuvant therapy for locally advanced pancreatic cancer?
    JOP : Journal of the pancreas, 2007, May-09, Volume: 8, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Drug Combinations; Fluorouracil; Gemcitabine; Humans; Neoadjuvant Therapy; Oxonic Acid; Paclitaxel; Pancreatic Neoplasms; Randomized Controlled Trials as Topic; Tegafur

2007
[Adjuvant chemotherapy for colorectal cancer in Japan-current state and problem areas].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Drug Combinations; Europe; Evidence-Based Medicine; Fluorouracil; Humans; Irinotecan; Japan; Leucovorin; Neoplasm Staging; Oxonic Acid; Practice Guidelines as Topic; Rectal Neoplasms; Tegafur; United States; Uracil

2007
[Treatments of pancreatic cancer from the standpoint of medical oncology].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Drug Administration Schedule; Drug Combinations; Erlotinib Hydrochloride; Fluorouracil; Gemcitabine; Humans; Oxonic Acid; Pancreatic Neoplasms; Quinazolines; Survival Rate; Tegafur

2007
Medical treatment for advanced gastroesophageal adenocarcinoma.
    Current opinion in gastroenterology, 2007, Volume: 23, Issue:6

    Topics: Adenocarcinoma; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Clinical Trials, Phase III as Topic; Deoxycytidine; Drug Combinations; Epirubicin; Esophageal Neoplasms; Fluorouracil; Humans; Oxonic Acid; Stomach Neoplasms; Tegafur; Treatment Outcome

2007
The multidisciplinary management of gastrointestinal cancer. The integration of cytotoxics and biologicals in the treatment of metastatic colorectal cancer.
    Best practice & research. Clinical gastroenterology, 2007, Volume: 21, Issue:6

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cell Death; Cell Survival; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; ErbB Receptors; Fluorouracil; Humans; Leucovorin; Neoplasm Metastasis; Tegafur; Treatment Outcome; Uracil; Vascular Endothelial Growth Factor A

2007
The role of UFT in advanced gastric cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2008, Volume: 19, Issue:6

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase II as Topic; Drug Therapy, Combination; Fluorouracil; Humans; Pyrimidines; Stomach Neoplasms; Tegafur; Uracil

2008
[Recent developments in systemic chemotherapy for hepatocellular carcinoma].
    The Korean journal of hepatology, 2008, Volume: 14, Issue:1

    Topics: Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Capecitabine; Carcinoma, Hepatocellular; Combined Modality Therapy; Deoxycytidine; Fluorouracil; Humans; Immunologic Factors; Liver Neoplasms; Tegafur

2008
An update on biochemotherapy of advanced gastric and gastroesophageal adenocarcinoma.
    Journal of the National Comprehensive Cancer Network : JNCCN, 2008, Volume: 6, Issue:9

    Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Capecitabine; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Deoxycytidine; Docetaxel; Drug Combinations; ErbB Receptors; Esophagogastric Junction; Fluorouracil; Humans; Irinotecan; Oxonic Acid; Radiation-Sensitizing Agents; Stomach Neoplasms; Taxoids; Tegafur; Vascular Endothelial Growth Factor A

2008
[Progress in chemotherapy for advanced gastric cancer].
    Ai zheng = Aizheng = Chinese journal of cancer, 2009, Volume: 28, Issue:10

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Cisplatin; Clinical Trials, Phase III as Topic; Deoxycytidine; Docetaxel; Doxorubicin; Drug Combinations; Fluorouracil; Gefitinib; Humans; Irinotecan; Methotrexate; Neoadjuvant Therapy; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Paclitaxel; Quinazolines; Stomach Neoplasms; Survival Rate; Taxoids; Tegafur; Trastuzumab

2009
[The current status of adjuvant chemotherapy of colonic cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:11

    Topics: Antimetabolites, Antineoplastic; Carnitine O-Palmitoyltransferase; Chemotherapy, Adjuvant; Colonic Neoplasms; Drug Delivery Systems; Fluorouracil; Humans; Tegafur

2009
Oral uracil-tegafur plus leucovorin vs fluorouracil bolus plus leucovorin for advanced colorectal cancer: a meta-analysis of five randomized controlled trials.
    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2011, Volume: 13, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Diarrhea; Fluorouracil; Humans; Infections; Leucovorin; Leukopenia; Mucositis; Neutropenia; Odds Ratio; Randomized Controlled Trials as Topic; Stomatitis; Survival Analysis; Tegafur; Uracil

2011
Therapeutic usefulness of postoperative adjuvant chemotherapy with Tegafur-Uracil (UFT) in patients with breast cancer: focus on the results of clinical studies in Japan.
    The oncologist, 2010, Volume: 15, Issue:1

    Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Chemotherapy, Adjuvant; Cisplatin; Clinical Trials as Topic; Deoxycytidine; Drug Combinations; Female; Floxuridine; Fluorouracil; Humans; Japan; Methotrexate; Oxonic Acid; Tegafur; Uracil

2010
A review of analytical methods for the determination of 5-fluorouracil in biological matrices.
    Analytical and bioanalytical chemistry, 2010, Volume: 397, Issue:3

    Topics: Antimetabolites, Antineoplastic; Chemistry Techniques, Analytical; Drug Monitoring; Fluorouracil; Humans; Prodrugs; Tegafur

2010
S-1-based therapy versus 5-FU-based therapy in advanced gastric cancer: a meta-analysis.
    Medical oncology (Northwood, London, England), 2011, Volume: 28, Issue:4

    Topics: Antineoplastic Agents; Drug Combinations; Fluorouracil; Humans; Middle Aged; Oxonic Acid; Randomized Controlled Trials as Topic; Stomach Neoplasms; Tegafur

2011
A comprehensive review of S-1 in the treatment of advanced gastric adenocarcinoma.
    Future oncology (London, England), 2011, Volume: 7, Issue:6

    Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Clinical Trials, Phase III as Topic; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Neoadjuvant Therapy; Neoplasm Staging; Oxonic Acid; Stomach Neoplasms; Tegafur

2011
S-1 for the treatment of gastrointestinal cancer.
    Expert opinion on pharmacotherapy, 2012, Volume: 13, Issue:13

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Drug Combinations; Fluorouracil; Gastrointestinal Neoplasms; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Practice Guidelines as Topic; Tegafur

2012
Second-line therapy in pancreatic cancer.
    JOP : Journal of the pancreas, 2013, Mar-10, Volume: 14, Issue:2

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Clinical Trials, Phase II as Topic; Drug Combinations; Fluorouracil; Humans; Irinotecan; Oxonic Acid; Pancreatic Neoplasms; Randomized Controlled Trials as Topic; Tegafur

2013
Applications of oral fluoropyrimidines in colon cancer: their role and new directions.
    Journal of the National Comprehensive Cancer Network : JNCCN, 2003, Volume: 1 Suppl 3

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colonic Neoplasms; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Enzyme Inhibitors; Fluorouracil; Humans; Oxaloacetates; Oxonic Acid; Tegafur; Uracil

2003
Survival prolongation after treatment failure of first-line chemotherapy in patients with advanced gastric cancer: combined analysis of the Japan Clinical Oncology group trials JCOG9205 and JCOG9912.
    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2014, Volume: 17, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Clinical Trials, Phase III as Topic; Drug Combinations; Female; Fluorouracil; Humans; Infusions, Intravenous; Irinotecan; Male; Middle Aged; Oxonic Acid; Randomized Controlled Trials as Topic; Stomach Neoplasms; Survival Rate; Tegafur; Time Factors; Treatment Failure; Treatment Outcome; Young Adult

2014
[Current status and future directions of chemotherapy for pancreatic cancer].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2013, Volume: 110, Issue:12

    Topics: Albumins; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Deoxycytidine; Drug Combinations; Erlotinib Hydrochloride; Fluorouracil; Gemcitabine; Humans; Leucovorin; Organoplatinum Compounds; Oxonic Acid; Paclitaxel; Pancreatic Neoplasms; Quinazolines; Tegafur

2013
S-1-based chemotherapy versus capecitabine-based chemotherapy as first-line treatment for advanced gastric carcinoma: a meta-analysis.
    PloS one, 2013, Volume: 8, Issue:12

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Disease Progression; Drug Combinations; Fluorouracil; Humans; Neoplasm Staging; Odds Ratio; Oxonic Acid; Publication Bias; Stomach Neoplasms; Tegafur; Time Factors; Treatment Outcome

2013
Comparison of the efficacy and safety of S-1-based and capecitabine-based regimens in gastrointestinal cancer: a meta-analysis.
    PloS one, 2014, Volume: 9, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Drug Combinations; Fluorouracil; Gastrointestinal Neoplasms; Humans; Odds Ratio; Oxonic Acid; Proportional Hazards Models; Publication Bias; Tegafur; Treatment Outcome

2014
[A case of advanced sigmoid colon cancer with metastases in the liver and the paraaortic lymph nodes successfully treated with 5-FU/l-LV and FOLFOX4 followed by S-1 leading to long-term complete response].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2014, Volume: 41, Issue:1

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Female; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Lymphatic Metastasis; Organoplatinum Compounds; Oxonic Acid; Sigmoid Neoplasms; Tegafur

2014
S-1-based versus 5-FU-based chemotherapy as first-line treatment in advanced gastric cancer: a meta-analysis of randomized controlled trials.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014, Volume: 35, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Fluorouracil; Humans; Oxonic Acid; Publication Bias; Randomized Controlled Trials as Topic; Stomach Neoplasms; Tegafur; Treatment Failure

2014
[Pharmacogenomics of the first-line treatment for gastric cancer: advances in the identification of genomic biomarkers for clinical response to chemotherapy].
    Investigacion clinica, 2014, Volume: 55, Issue:2

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biological Transport; Biomarkers; Biotransformation; Capecitabine; Combined Modality Therapy; Deoxycytidine; Drug Combinations; Drug Resistance, Neoplasm; Enzymes; Ethnicity; Fluorouracil; Gastrectomy; Humans; Mexico; Molecular Targeted Therapy; Organoplatinum Compounds; Oxonic Acid; Patient Selection; Pharmacogenetics; Precision Medicine; Prodrugs; Stomach Neoplasms; Tegafur

2014
Survival benefit from S-1 as compared to Fluorouracil in Asian patients with advanced gastrointestinal cancer: a meta-analysis.
    Cancer science, 2014, Volume: 105, Issue:8

    Topics: Antineoplastic Agents; Asian People; Drug Combinations; Fluorouracil; Gastrointestinal Neoplasms; Humans; Oxonic Acid; Randomized Controlled Trials as Topic; Tegafur; Treatment Outcome

2014
The efficacy and toxicity of paclitaxel plus S-1 compared with paclitaxel plus 5-FU for advanced gastric cancer: a PRISMA systematic review and meta-analysis of randomized controlled trials.
    Medicine, 2014, Volume: 93, Issue:25

    Topics: Age Factors; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Disease Progression; Drug Combinations; Fluorouracil; Neoplasm Staging; Oxonic Acid; Risk Factors; Sex Factors; Stomach Neoplasms; Tegafur

2014
Role of ABC transporters in fluoropyrimidine-based chemotherapy response.
    Advances in cancer research, 2015, Volume: 125

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; ATP-Binding Cassette Transporters; Biological Availability; Biological Transport; Camptothecin; Capecitabine; Deoxycytidine; Drug Resistance, Neoplasm; Fluorouracil; Humans; Leucovorin; Neoplasms; Organoplatinum Compounds; Tegafur

2015
[Adjuvant treatment for esophagogastric junction cancer].
    Nihon Geka Gakkai zasshi, 2015, Volume: 116, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asia; Capecitabine; Carboplatin; Chemoradiotherapy, Adjuvant; Chemotherapy, Adjuvant; Cisplatin; Clinical Trials as Topic; Deoxycytidine; Digestive System Surgical Procedures; Docetaxel; Drug Combinations; Esophageal Neoplasms; Esophagogastric Junction; Europe; Fluorouracil; Humans; Lymph Node Excision; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Paclitaxel; Stomach Neoplasms; Taxoids; Tegafur

2015
A Meta-analysis Reveals S-1-based Chemotherapy Improves the Survival of Patients With Advanced Gastric Cancer.
    Medicine, 2015, Volume: 94, Issue:16

    Topics: Capecitabine; China; Clinical Trials as Topic; Deoxycytidine; Disease-Free Survival; Drug Combinations; Female; Fluorouracil; Humans; Male; Oxonic Acid; Severity of Illness Index; Stomach Neoplasms; Tegafur

2015
[CURRENT STATE OF ADJUVANT TREATMENT FOR GASTRIC CANCER AFTER RADICAL SURGERY WITH EXTENDED LYMPH NODE DISSECTION].
    Voprosy onkologii, 2015, Volume: 61, Issue:3

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Camptothecin; Capecitabine; Chemotherapy, Adjuvant; Cisplatin; Deoxycytidine; Docetaxel; Drug Combinations; Fluorouracil; Gastrectomy; Humans; Leucovorin; Lymph Node Excision; Multicenter Studies as Topic; Oxaloacetates; Oxonic Acid; Paclitaxel; Radiotherapy, Adjuvant; Randomized Controlled Trials as Topic; Stomach Neoplasms; Survival Analysis; Survival Rate; Taxoids; Tegafur; Treatment Outcome

2015
S-1-based regimens and the risk of oral and gastrointestinal mucosal injury: a meta-analysis with comparison to other fluoropyrimidines.
    Expert opinion on drug safety, 2016, Volume: 15, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Diarrhea; Drug Combinations; Fluorouracil; Humans; Intestinal Mucosa; Mouth Mucosa; Neoplasms; Oxonic Acid; Randomized Controlled Trials as Topic; Stomatitis; Tegafur

2016
Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient data.
    The Lancet. Oncology, 2015, Volume: 16, Issue:16

    Topics: Antimetabolites, Antineoplastic; Capecitabine; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Gastrointestinal Diseases; Genetic Predisposition to Disease; Hematologic Diseases; Humans; Multivariate Analysis; Neoplasms; Odds Ratio; Pharmacogenetics; Phenotype; Polymorphism, Genetic; Risk Assessment; Risk Factors; Severity of Illness Index; Tegafur

2015
High/positive expression of 5-fluorouracil metabolic enzymes predicts better response to S-1 in patients with gastric cancer: a meta-analysis.
    The International journal of biological markers, 2016, May-28, Volume: 31, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Drug Combinations; Fluorouracil; Humans; Orotate Phosphoribosyltransferase; Oxonic Acid; Stomach Neoplasms; Tegafur; Thymidine Phosphorylase; Thymidylate Synthase

2016
Fluoropyrimidine-Based Chemotherapy as First-Line Treatment for Advanced Gastric Cancer: a Bayesian Network Meta-Analysis.
    Pathology oncology research : POR, 2016, Volume: 22, Issue:4

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bayes Theorem; Capecitabine; Disease-Free Survival; Drug Combinations; Fluorouracil; Humans; Middle Aged; Network Meta-Analysis; Oxonic Acid; Pyruvates; Stomach Neoplasms; Tegafur

2016
Can S-1 replace fluorouracil for advanced gastric cancer? A PRISMA-compliant systematic review and meta-analysis.
    Medicine, 2016, Volume: 95, Issue:24

    Topics: Antimetabolites, Antineoplastic; Drug Combinations; Fluorouracil; Humans; Neoplasm Staging; Oxonic Acid; Prognosis; Stomach Neoplasms; Tegafur

2016
The Efficacy and Safety of First-line Chemotherapy in Advanced Esophagogastric Cancer: A Network Meta-analysis.
    Journal of the National Cancer Institute, 2016, Volume: 108, Issue:10

    Topics: Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Bridged-Ring Compounds; Camptothecin; Capecitabine; Cisplatin; Disease-Free Survival; Drug Combinations; Esophageal Neoplasms; Esophagogastric Junction; Fluorouracil; Humans; Irinotecan; Methotrexate; Network Meta-Analysis; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Randomized Controlled Trials as Topic; Stomach Neoplasms; Survival Rate; Taxoids; Tegafur

2016
Significant efficacy and well safety of apatinib in an advanced liver cancer patient: a case report and literature review.
    Oncotarget, 2017, Mar-21, Volume: 8, Issue:12

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Disease-Free Survival; Ethiodized Oil; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Pyridines; Tegafur

2017
Oral versus intravenous fluoropyrimidines for colorectal cancer.
    The Cochrane database of systematic reviews, 2017, Jul-28, Volume: 7

    Topics: Administration, Oral; Adult; Antineoplastic Agents; Camptothecin; Capecitabine; Chemotherapy, Adjuvant; Colorectal Neoplasms; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Humans; Injections, Intravenous; Irinotecan; Male; Neoadjuvant Therapy; Organoplatinum Compounds; Palliative Care; Pyridines; Pyrimidines; Randomized Controlled Trials as Topic; Tegafur; Uracil

2017
Capecitabine, 5-fluorouracil and S-1 based regimens for previously untreated advanced oesophagogastric cancer: A network meta-analysis.
    Scientific reports, 2017, 08-02, Volume: 7, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Drug Combinations; Esophageal Neoplasms; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Staging; Oxonic Acid; Proportional Hazards Models; Publication Bias; Stomach Neoplasms; Tegafur; Treatment Outcome

2017
Novel fluoropyrimidine-based chemotherapy for advanced well-differentiated neuroendocrine tumors: a clinical update.
    Expert opinion on pharmacotherapy, 2018, Volume: 19, Issue:8

    Topics: Antimetabolites, Antineoplastic; Capecitabine; Disease-Free Survival; Drug Combinations; Drug Therapy, Combination; Fluorouracil; Humans; Neoplasm Staging; Neuroendocrine Tumors; Oxonic Acid; Pyrimidines; Tegafur; Treatment Outcome

2018
Comparative effectiveness of adjuvant treatments for resected gastric cancer: a network meta-analysis.
    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2018, Volume: 21, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bayes Theorem; Capecitabine; Chemoradiotherapy, Adjuvant; Deoxycytidine; Disease-Free Survival; Drug Combinations; Fluorouracil; Humans; Lymph Node Excision; Network Meta-Analysis; Oxaloacetates; Oxonic Acid; Stomach Neoplasms; Survival Analysis; Tegafur

2018
Systemic 5-fluorouracil induced lupus erythematosus: a review of the literature.
    Dermatology online journal, 2019, Nov-15, Volume: 25, Issue:11

    Topics: Age Distribution; Aged; Antimetabolites, Antineoplastic; Capecitabine; Female; Fluorouracil; Humans; Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Systemic; Male; Middle Aged; Sex Distribution; Tegafur

2019
Comparison of Platinum/S-1 and Platinum/5-Fluorouracil as First-Line Chemotherapy for Advanced Gastric or Gastroesophageal Junction Cancer: A Meta-Analysis Based on Randomized Controlled Trials.
    Chemotherapy, 2020, Volume: 65, Issue:1-2

    Topics: Antineoplastic Agents; Coordination Complexes; Disease-Free Survival; Drug Combinations; Drug Therapy, Combination; Esophagogastric Junction; Fluorouracil; Gastrointestinal Neoplasms; Humans; Neoplasm Staging; Oxonic Acid; Platinum; Proportional Hazards Models; Randomized Controlled Trials as Topic; Stomach Neoplasms; Survival Analysis; Tegafur; Treatment Outcome

2020
Dihydropyrimidine Dehydrogenase Testing prior to Treatment with 5-Fluorouracil, Capecitabine, and Tegafur: A Consensus Paper.
    Oncology research and treatment, 2020, Volume: 43, Issue:11

    Topics: Antimetabolites, Antineoplastic; Austria; Capecitabine; Consensus; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Genetic Testing; Genotype; Germany; Humans; Male; Mutation; Neoplasms; Phenotype; Practice Guidelines as Topic; Switzerland; Tegafur

2020
Relationships between pathological factors and long-term outcomes in patients enrolled in two prospective randomized controlled trials comparing the efficacy of oral tegafur-uracil with CMF (N·SAS-BC 01 trial and CUBC trial).
    Breast cancer research and treatment, 2021, Volume: 186, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Disease-Free Survival; Female; Fluorouracil; Follow-Up Studies; Humans; Methotrexate; Neoplasm Recurrence, Local; Prospective Studies; Randomized Controlled Trials as Topic; Tegafur

2021
Uracil-tegafur vs fluorouracil as postoperative adjuvant chemotherapy in Stage II and III colon cancer: A nationwide cohort study and meta-analysis.
    Medicine, 2021, May-07, Volume: 100, Issue:18

    Topics: Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Colectomy; Colonic Neoplasms; Disease-Free Survival; Female; Fluorouracil; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Randomized Controlled Trials as Topic; Retrospective Studies; Taiwan; Tegafur

2021
HER2-Directed Therapy in Advanced Gastric and Gastroesophageal Adenocarcinoma: Triumphs and Troubles.
    Current treatment options in oncology, 2021, 08-23, Volume: 22, Issue:10

    Topics: Adenocarcinoma; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cisplatin; Clinical Trials as Topic; Drug Combinations; Drug Resistance, Neoplasm; Esophagogastric Junction; Fluorouracil; Humans; Irinotecan; Lapatinib; Oxaliplatin; Oxonic Acid; Paclitaxel; Receptor, ErbB-2; Stomach Neoplasms; Tegafur; Trastuzumab

2021
Comparative Outcomes of First-Line Chemotherapy for Metastatic Pancreatic Cancer Among the Regimens Used in Japan: A Systematic Review and Network Meta-analysis.
    JAMA network open, 2022, 01-04, Volume: 5, Issue:1

    Topics: Albumins; Antineoplastic Combined Chemotherapy Protocols; Comparative Effectiveness Research; Deoxycytidine; Drug Combinations; Fluorouracil; Gemcitabine; Humans; Irinotecan; Japan; Kaplan-Meier Estimate; Leucovorin; Neoplasm Metastasis; Network Meta-Analysis; Oxaliplatin; Oxonic Acid; Paclitaxel; Pancreatic Neoplasms; Progression-Free Survival; Proportional Hazards Models; Pyridines; Survival Rate; Tegafur; Treatment Outcome

2022

Trials

233 trial(s) available for fluorouracil and tegafur

ArticleYear
Chemotherapy for adenocarcinoma and large cell anaplastic carcinoma of the lung with ftorafur, adriamycin, and cis-dichlorodiammineplatinum(II).
    Cancer treatment reports, 1978, Volume: 62, Issue:7

    Topics: Adenocarcinoma; Adult; Aged; Carcinoma, Small Cell; Cisplatin; Clinical Trials as Topic; Doxorubicin; Drug Evaluation; Drug Therapy, Combination; Fluorouracil; Humans; Lung Neoplasms; Middle Aged; Tegafur

1978
Protracted oral chemotherapy with fluorinated pyrimidines as an adjuvant to surgical treatment for stomach cancer.
    Annals of surgery, 1977, Volume: 185, Issue:4

    Topics: Administration, Oral; Adult; Aged; Drug Therapy, Combination; Female; Fluorouracil; Follow-Up Studies; Gastrectomy; Humans; Male; Middle Aged; Stomach Neoplasms; Tegafur

1977
Phase II trial of ftorafur with mitomycin C versus ftorafur with methyl-CCNU in untreated colorectal cancer.
    Cancer treatment reports, 1978, Volume: 62, Issue:5

    Topics: Adenocarcinoma; Adult; Aged; Clinical Trials as Topic; Colonic Neoplasms; Drug Evaluation; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Middle Aged; Mitomycins; Nitrosourea Compounds; Rectal Neoplasms; Semustine; Tegafur

1978
[Treatment of acute pancreatitis].
    Vestnik khirurgii imeni I. I. Grekova, 1979, Volume: 122, Issue:6

    Topics: Acute Disease; Adolescent; Adult; Aged; Clinical Trials as Topic; Drug Evaluation; Female; Fluorouracil; Humans; Male; Middle Aged; Pancreatectomy; Pancreatitis; Recurrence; Tegafur

1979
[A prospective multi-centre study of the response of metastatic gastrointestinal tumours (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1979, Aug-31, Volume: 104, Issue:35

    Topics: Adenocarcinoma; Carmustine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Intestinal Neoplasms; Middle Aged; Pancreatic Neoplasms; Prognosis; Prospective Studies; Stomach Neoplasms; Tegafur

1979
[Multicenter cooperative study of pre- and post-operative adjuvant chemotherapy in the treatment of colorectal cancer. North Kyushu Co-operative Study Group for Cancer Chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:12

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Fluorouracil; Humans; Lymph Nodes; Rectal Neoplasms; Suppositories; Survival Rate; Tegafur; Uracil

1992
Early postoperative chemotherapy following noncurative resection for patients with advanced gastric cancer.
    British journal of cancer, 1992, Volume: 65, Issue:3

    Topics: Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Fluorouracil; Humans; Male; Middle Aged; Mitomycin; Picibanil; Prospective Studies; Proteoglycans; Stomach Neoplasms; Tegafur; Uracil

1992
[Evaluation of UFT administration in patients with ovarian cancer who had no evidence of disease after the initial therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:3 Pt 1

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Drug Administration Schedule; Female; Fluorouracil; Humans; Middle Aged; Ovarian Neoplasms; Reoperation; Tegafur; Uracil

1990
Doxorubicin and 5-fluorouracil versus doxorubicin and oral ftorafur in in the treatment of advanced gastric cancer--a phase II and III trial.
    Acta oncologica (Stockholm, Sweden), 1990, Volume: 29, Issue:7

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Drug Evaluation; Female; Fluorouracil; Humans; Male; Middle Aged; Stomach Neoplasms; Survival Rate; Tegafur

1990
[Adjuvant chemotherapy for gastric cancer--the third study. First report: central randomization by telephone method and analysis of patients' background factors].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:3 Pt 1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cytarabine; Drug Administration Schedule; Fluorouracil; Humans; Japan; Mitomycin; Mitomycins; Multicenter Studies as Topic; Picibanil; Random Allocation; Stomach Neoplasms; Tegafur; Telephone

1989
[Outcome of adjuvant mifurol chemotherapy in patients with resected colonic carcinoma].
    Gan no rinsho. Japan journal of cancer clinics, 1989, Volume: 35, Issue:9

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Combined Modality Therapy; Drug Evaluation; Female; Fluorouracil; Follow-Up Studies; Humans; Japan; Male; Middle Aged; Mitomycin; Mitomycins; Multicenter Studies as Topic; Tegafur

1989
Comparison of oral ftorafur and intravenous 5-fluorouracil in patients with advanced cancer of the stomach, colon or rectum.
    Oncology, 1986, Volume: 43, Issue:4

    Topics: Actuarial Analysis; Adenocarcinoma; Aged; Colonic Neoplasms; Female; Fluorouracil; Humans; Male; Middle Aged; Prospective Studies; Random Allocation; Rectal Neoplasms; Stomach Neoplasms; Tegafur

1986
Chemotherapy of advanced gastric carcinoma (stage IV): a randomized study of FAM versus 5-FU plus BCNU.
    Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1987, Volume: 6, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Clinical Trials as Topic; Doxorubicin; Drug Evaluation; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Middle Aged; Mitomycin; Mitomycins; Prospective Studies; Random Allocation; Stomach Neoplasms; Tegafur

1987
Oral ftorafur versus intravenous 5-fluorouracil. A comparative study in patients with colorectal cancer.
    Acta oncologica (Stockholm, Sweden), 1987, Volume: 26, Issue:6

    Topics: Administration, Oral; Adult; Aged; Blood Platelets; Colonic Neoplasms; Female; Fluorouracil; Humans; Injections, Intravenous; Leukocytes; Male; Middle Aged; Random Allocation; Rectal Neoplasms; Retrospective Studies; Tegafur

1987
[Controlled study of MQF-OK therapy with FT and with UFT on various advanced gastrointestinal cancers. Hirosaki Cooperative Study Group of Cancer Chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:7

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carbazilquinone; Clinical Trials as Topic; Double-Blind Method; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Mitomycin; Mitomycins; Picibanil; Remission Induction; Stomach Neoplasms; Tegafur; Uracil

1988
[Clinical evaluation of schizophyllan (SPG) in advanced gastric cancer (the second report)--a randomized controlled study].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Drug Administration Schedule; Fluorouracil; Glycosaminoglycans; Humans; Mitomycin; Mitomycins; Random Allocation; Sizofiran; Stomach Neoplasms; Tegafur

1985
[Preliminary report of adjuvant chemo-endocrine therapy for breast cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:1

    Topics: Adult; Anorexia; Breast Neoplasms; Chemical and Drug Induced Liver Injury; Combined Modality Therapy; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Lymph Node Excision; Mastectomy; Middle Aged; Nausea; Postoperative Care; Tamoxifen; Tegafur

1985
[Results of phase III study of lentinan].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colonic Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Humans; Lentinan; Male; Middle Aged; Mitomycin; Mitomycins; Polysaccharides; Random Allocation; Rectal Neoplasms; Stomach Neoplasms; Tegafur

1985
[A controlled study of surgical adjuvant chemoimmunotherapy with FT-207 and OK-432 for advanced stomach cancer: the fourth study].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:3 Pt 1

    Topics: Administration, Oral; Aged; Biological Products; Clinical Trials as Topic; Combined Modality Therapy; Female; Fluorouracil; Gastrectomy; Humans; Injections, Subcutaneous; Male; Middle Aged; Picibanil; Postoperative Care; Prospective Studies; Random Allocation; Stomach Neoplasms; Tegafur

1985
[Randomized study of long-term adjuvant chemotherapy with Futraful and mitomycin C in gastric cancer. A second study (fourth report)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:9

    Topics: Clinical Trials as Topic; Drug Administration Schedule; Drug Synergism; Fluorouracil; Humans; Mitomycin; Mitomycins; Postoperative Care; Random Allocation; Stomach Neoplasms; Tegafur

1985
[Chemotherapy of tumors of the gastrointestinal tract].
    Sovetskaia meditsina, 1985, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Digestive System Neoplasms; Doxorubicin; Fluorouracil; Humans; Lomustine; Mitomycin; Mitomycins; Tegafur

1985
[A randomized controlled study to compare 1-hexylcarbamoyl-5-fluorouracil (HCFU) and 1-(2-tetrahydrofuryl)-5-fluorouracil (Tegafur) for the prevention of post-operative recurrence of bladder cancer].
    Hinyokika kiyo. Acta urologica Japonica, 1985, Volume: 31, Issue:7

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Clinical Trials as Topic; Drug Administration Schedule; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Postoperative Period; Random Allocation; Tegafur; Urinary Bladder; Urinary Bladder Neoplasms

1985
[Results of the Hamburg ovarian blastoma study].
    Onkologie, 1985, Volume: 8, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Female; Fluorouracil; Germany, West; Humans; Ifosfamide; Melphalan; Methotrexate; Neoplasm Staging; Ovarian Neoplasms; Prognosis; Random Allocation; Tegafur; Vincristine

1985
Clinical trials on UFT in the treatment of head and neck cancer.
    Auris, nasus, larynx, 1985, Volume: 12 Suppl 2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Clinical Trials as Topic; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Male; Middle Aged; Tegafur; Uracil

1985
[Multidisciplinary therapy for esophageal carcinoma. Cooperative Study Group for Esophageal Carcinoma].
    Gan no rinsho. Japan journal of cancer clinics, 1984, Volume: 30, Issue:5

    Topics: Alcohol Drinking; Bleomycin; Combined Modality Therapy; Esophageal Neoplasms; Female; Fluorouracil; Humans; Male; Prognosis; Smoking; Tegafur

1984
Chemotherapy of large bowel cancer.
    Cancer, 1982, Dec-01, Volume: 50, Issue:11 Suppl

    Topics: Antineoplastic Agents; Clinical Trials as Topic; Drug Therapy, Combination; Floxuridine; Fluorouracil; Follow-Up Studies; Humans; Intestinal Neoplasms; Liver Neoplasms; Semustine; Tegafur; Vincristine

1982
Clinical trials with oral Futraful (INN: Tegafur) in cancer of the head and neck.
    Clinical oncology, 1981, Volume: 7, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Aged; Antineoplastic Agents; Carcinoma, Adenoid Cystic; Carcinoma, Squamous Cell; Clinical Trials as Topic; Drug Therapy, Combination; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Male; Mouth Neoplasms; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Neoplasm Recurrence, Local; Picibanil; Proteoglycans; Tegafur

1981
A comparative study of oral tegafur and intravenous 5-fluorouracil in patients with metastatic colorectal cancer.
    American journal of clinical oncology, 1983, Volume: 6, Issue:2

    Topics: Administration, Oral; Colonic Neoplasms; Drug Evaluation; Female; Fluorouracil; Humans; Injections, Intravenous; Male; Nausea; Neoplasm Metastasis; Neutropenia; Random Allocation; Rectal Neoplasms; Tegafur; Thrombocytopenia

1983
[Clinical study on combination chemotherapy of primary liver cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:4 Pt 1

    Topics: Adult; Aged; Azirines; Carbazilquinone; Clinical Trials as Topic; Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouracil; Humans; Liver Neoplasms; Male; Middle Aged; Random Allocation; Tegafur

1983
Chemotherapy of disseminated gastric cancer. A joint effort of the Northern California Oncology Group and the Japanese Gastric Cancer Chemotherapy Group.
    Cancer, 1983, Nov-15, Volume: 52, Issue:10

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; California; Clinical Trials as Topic; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Japan; Male; Middle Aged; Stomach Neoplasms; Tegafur

1983
[Randomized study on the long-term adjuvant chemotherapy with ftorafur and mitomycin C for stomach cancer: second report].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:11

    Topics: Drug Therapy, Combination; Fluorouracil; Humans; Mitomycin; Mitomycins; Postoperative Period; Random Allocation; Stomach Neoplasms; Tegafur

1983
[Comparative study on two different types of tegafur for recurrent breast cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:2

    Topics: Administration, Oral; Adult; Aged; Breast Neoplasms; Capsules; Delayed-Action Preparations; Drug Evaluation; Female; Fluorouracil; Humans; Middle Aged; Neoplasm Recurrence, Local; Tegafur

1984
[Immunological approach and surgical treatment of cancer].
    Gan no rinsho. Japan journal of cancer clinics, 1983, Volume: 29, Issue:13

    Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Fluorouracil; Gastrectomy; Humans; Mitomycin; Mitomycins; Picibanil; Prospective Studies; Stomach Neoplasms; Tegafur

1983
Clinical evaluation of prolonged chemotherapy combined with induction of hepatic drug-metabolizing enzymes as an adjuvant for treating patients with gastric cancer.
    The Japanese journal of surgery, 1983, Volume: 13, Issue:6

    Topics: Clinical Trials as Topic; Cytochrome P-450 Enzyme System; Drug Therapy, Combination; Enzyme Induction; Fluorouracil; Glutathione; Humans; Microsomes, Liver; Phenobarbital; Random Allocation; Stomach Neoplasms; Tegafur; Time Factors

1983
[Joint clinical Phase II study of SF-SP].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:6

    Topics: Clinical Trials as Topic; Colonic Neoplasms; Delayed-Action Preparations; Drug Evaluation; Female; Fluorouracil; Humans; Liver Neoplasms; Male; Neoplasms; Pancreatic Neoplasms; Stomach Neoplasms; Tegafur

1984
[A randomized study on the long-term adjuvant chemotherapy with ftorafur and mitomycin C for gastric cancer: the second study (III)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:9

    Topics: Clinical Trials as Topic; Drug Administration Schedule; Fluorouracil; Humans; Mitomycin; Mitomycins; Postoperative Period; Random Allocation; Stomach Neoplasms; Tegafur

1984
Levamisole in postoperative adjuvant immunochemotherapy for gastric cancer. A randomized controlled study of the MMC + Tegafur regimen with or without levamisole. Report I.
    Cancer immunology, immunotherapy : CII, 1984, Volume: 18, Issue:1

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Combined Modality Therapy; Female; Fluorouracil; Follow-Up Studies; Humans; Immunotherapy; Levamisole; Male; Middle Aged; Mitomycin; Mitomycins; Stomach Neoplasms; Tegafur

1984
[Evaluation of preoperative administration of N1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) suppository in surgical adjuvant chemotherapy for large bowel cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:11

    Topics: Adult; Colonic Neoplasms; Colostomy; Female; Fluorouracil; Humans; Male; Middle Aged; Preoperative Care; Prospective Studies; Rectal Neoplasms; Suppositories; Tegafur

1984
Comparison of 5-fluorouracil with ftorafur in adjuvant chemotherapies with combined inductive and maintenance therapies for gastric cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1984, Volume: 2, Issue:12

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Fluorouracil; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Metastasis; Stomach Neoplasms; Tegafur

1984
Methyl-CCNU and ftorafur in treatment of rectosigmoidal tumors and ftorafur capsules in treatment of colorectal tumors.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1981, Volume: 79

    Topics: Capsules; Clinical Trials as Topic; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Humans; Nitrosourea Compounds; Rectal Neoplasms; Semustine; Sigmoid Neoplasms; Tegafur

1981
Comparison of ftorafur with 5-fluorouracil in combination chemotherapy of advanced gastrointestinal carcinoma.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1981, Volume: 79

    Topics: Adult; Carmustine; Drug Therapy, Combination; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Male; Neoplasm Metastasis; Tegafur; Time Factors

1981
Tamoxifen alone versus tamoxifen plus 1-(2-tetrahydrofuryl)-5-fluorouracil in the treatment of advanced breast cancer: a sequential trial.
    Breast cancer research and treatment, 1981, Volume: 1, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluorouracil; Humans; Menopause; Middle Aged; Tamoxifen; Tegafur

1981
[Effect of levamisole in postoperative adjuvant immunochemotherapy of stomach cancer--randomized controlled study of MMC-tegafur combination therapy with or without levamisole. 1].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:12

    Topics: Adjuvants, Immunologic; Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Agents; Clinical Trials as Topic; Drug Therapy, Combination; Fluorouracil; Follow-Up Studies; Humans; Leukocyte Count; Levamisole; Lymphocytes; Middle Aged; Mitomycin; Mitomycins; Postoperative Care; Random Allocation; Stomach Neoplasms; Tegafur

1982
[Effect of postoperative long-term chemotherapy of stomach cancer using mitomycin C and futraful--the secondary study (1)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:8

    Topics: Aged; Antibiotics, Antineoplastic; Blood Cell Count; Body Weight; Clinical Trials as Topic; Drug Therapy, Combination; Fluorouracil; Humans; Mitomycin; Mitomycins; Postoperative Complications; Random Allocation; Stomach Neoplasms; Tegafur; Time Factors

1982
[High tissue concentration of 5-FU reduced local recurrence after administration of tegafur suppositories].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1995, Volume: 22, Issue:8

    Topics: Chemotherapy, Adjuvant; Fluorouracil; Head and Neck Neoplasms; Humans; Lymphatic Metastasis; Neoplasm Recurrence, Local; Preoperative Care; Suppositories; Tegafur

1995
Randomized study with mitomycin C + 5-fluorouracil+cytosine arabinoside (MFC)+5-fluorouracil, MFC+tegafur and uracil (UFT), and MF+UFT in advanced gastric cancer: interinstitutional differences in a multicenter study in Japan.
    Journal of surgical oncology, 1995, Volume: 60, Issue:1

    Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cytarabine; Drug Administration Schedule; Female; Fluorouracil; Gastrectomy; Humans; Japan; Male; Middle Aged; Mitomycin; Stomach Neoplasms; Survival Rate; Tegafur; Uracil

1995
[Usefulness of adjuvant chemotherapy with antimetabolites for cervical invasive cancer].
    Nihon Sanka Fujinka Gakkai zasshi, 1995, Volume: 47, Issue:3

    Topics: Adenocarcinoma; Administration, Oral; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Female; Fluorouracil; Humans; Retrospective Studies; Survival Rate; Tegafur; Uterine Cervical Neoplasms

1995
[Pharmacokinetic study of UFT in cancer patients receiving maintenance dialysis].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1995, Volume: 22, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Female; Fluorouracil; Humans; Kidney Failure, Chronic; Male; Middle Aged; Postoperative Care; Renal Dialysis; Stomach Neoplasms; Tegafur; Uracil

1995
[5-FU concentrations in the blood and tumor tissue after 5'-DFUR or UFT administration in the patients with uterine cervical cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1995, Volume: 22, Issue:2

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Female; Floxuridine; Fluorouracil; Humans; Lymph Nodes; Middle Aged; Tegafur; Uracil; Uterine Cervical Neoplasms

1995
[Combination chemotherapy with FP versus FEP in patients with advanced gastric cancer. Research group of gastric cancer chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1995, Volume: 22, Issue:4

    Topics: Adenocarcinoma; Aged; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Etoposide; Female; Fluorouracil; Humans; Leukopenia; Lymphatic Metastasis; Male; Middle Aged; Proportional Hazards Models; Stomach Neoplasms; Survival Rate; Tegafur; Uracil; Vomiting

1995
[The significance of portal infusion chemotherapy for prevention of recurrence in residual liver after hepatectomy for metastases from colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:13

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Fluorouracil; Hepatectomy; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Infusions, Intravenous; Liver Neoplasms; Male; Middle Aged; Mitomycin; Neoplasm Recurrence, Local; Neoplasm, Residual; Portal Vein; Tegafur; Uracil

1994
Chemo-endocrine therapy for prostate cancer with bone metastasis. Nagasaki Prostate Cancer Research Group.
    Cancer chemotherapy and pharmacology, 1994, Volume: 35 Suppl

    Topics: Aged; Aged, 80 and over; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Epirubicin; Ethinyl Estradiol; Fluorouracil; Follow-Up Studies; Humans; Longitudinal Studies; Male; Middle Aged; Multivariate Analysis; Orchiectomy; Prognosis; Proportional Hazards Models; Prostatic Neoplasms; Survival Rate; Tegafur; Uracil

1994
[Randomized controlled trial of MMC + UFT and MMC + 5-FU therapy in advanced gastric cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Humans; Mitomycin; Quality of Life; Stomach Neoplasms; Survival Analysis; Tegafur; Uracil

1994
[The usefulness of pre- and immediately postoperative chemotherapy in colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:8

    Topics: Adenocarcinoma; Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Fluorouracil; Humans; Infusions, Intravenous; Lymphatic Metastasis; Mitomycin; Postoperative Care; Preoperative Care; Tegafur; Uracil

1994
[A multicenter cooperative study on supplementary chemotherapy of uterocervical cancer. The Kyushu UFT Study Group of Uterocervical Cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:8

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Female; Fluorouracil; Humans; Middle Aged; Survival Rate; Tegafur; Uracil; Uterine Cervical Neoplasms

1994
[A double-blind comparison of FUra plasma concentration by oral (UFT) vs continuous intravenous infusion (5-FU)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:15

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Double-Blind Method; Fluorouracil; Humans; Infusions, Intravenous; Stomach Neoplasms; Tegafur; Uracil

1993
[Determination of 5-FU tissue concentrations after oral UFT administration in tumors of the head and neck].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1996, Volume: 23, Issue:1

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Lymphatic Metastasis; Male; Middle Aged; Tegafur; Uracil

1996
Treatment of patients with advanced gastric carcinoma with the combination of etoposide plus oral tegafur modulated by uracil and leucovorin. A phase II study of the ONCOPAZ Cooperative Group.
    Cancer, 1996, Jul-15, Volume: 78, Issue:2

    Topics: Administration, Oral; Adult; Aged; Ambulatory Care; Anemia; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Diarrhea; Drug Administration Schedule; Etoposide; Fluorouracil; Humans; Injections, Intravenous; Leucovorin; Middle Aged; Nausea; Remission Induction; Stomach Neoplasms; Survival Rate; Tegafur; Vomiting

1996
[Neoadjuvant therapy followed by administration of UFT for breast cancer patients].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1996, Volume: 23, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Drug Combinations; Female; Fluorouracil; Humans; Middle Aged; Remission Induction; Tegafur; Uracil

1996
[Comparative clinical study of adjuvant postoperative chemotherapy (5-FU, Tegafur, 5-FU + MMC) in curatively resected cases of gastric cancer. Study Group on 5-FU Oral Adjuvant Chemotherapy in Gastric Cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1996, Volume: 23, Issue:9

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Female; Fluorouracil; Gastrectomy; Humans; Male; Middle Aged; Mitomycin; Stomach Neoplasms; Survival Rate; Tegafur

1996
[Combined chemotherapy with 5-FU and low dose CDDP for advanced or recurrent cancer of the digestive system and home anti-cancer chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1995, Volume: 22 Suppl 4

    Topics: Administration, Oral; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Digestive System Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Home Care Services, Hospital-Based; Humans; Infusion Pumps; Infusions, Intravenous; Male; Neoplasm Recurrence, Local; Quality of Life; Tegafur; Uracil

1995
[Outpatient chemotherapy with continuous infusion of 5-fluorouracil (CI 5-FU) and intravenous bolus leucovorin (IVB LV) in advanced gastrointestinal cancer: the second report].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1995, Volume: 22 Suppl 4

    Topics: Administration, Oral; Aged; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Fluorouracil; Gastrointestinal Neoplasms; Home Care Services, Hospital-Based; Humans; Infusion Pumps; Infusions, Intravenous; Injections, Intravenous; Leucovorin; Male; Middle Aged; Quality of Life; Tegafur; Uracil

1995
Advanced colorectal carcinoma: redefining the role of oral ftorafur.
    Anti-cancer drugs, 1996, Volume: 7, Issue:6

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Fluorouracil; Home Nursing; Humans; Karnofsky Performance Status; Leucovorin; Male; Middle Aged; Quality of Life; Tegafur

1996
[Combination chemotherapy with 5-FU and CDDP or CDDP analog for head and neck cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1996, Volume: 23, Issue:13

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Cisplatin; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Infusions, Intravenous; Male; Middle Aged; Survival Rate; Tegafur; Uracil

1996
A comparative, randomized trial of UFT and 5-fluorouracil in combination with cyclophosphamide and doxorubicin in the treatment of advanced breast cancer patients at The Philippines General Hospital.
    Oncology, 1997, Volume: 54 Suppl 1

    Topics: Administration, Oral; Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Drug Combinations; Fluorouracil; Humans; Middle Aged; Neoplasm Metastasis; Tegafur; Uracil

1997
Clinical application of biochemical modulation in cancer chemotherapy: biochemical modulation for 5-FU.
    Oncology, 1997, Volume: 54 Suppl 1

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Combinations; Fluorouracil; Humans; Japan; Tegafur; Uracil

1997
[Low-dose cisplatin added to continuous infusion of 5-fluorouracil or oral administration of UFT for inoperable advanced or recurrent colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:1

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colonic Neoplasms; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasm Recurrence, Local; Rectal Neoplasms; Tegafur; Uracil

1997
[Preoperative adjuvant chemotherapy with oral anticancer agents for stomach cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:9

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Fluorouracil; Humans; Lymphatic Metastasis; Male; Middle Aged; Multivariate Analysis; Stomach Neoplasms; Survival Rate; Tablets; Tegafur

1997
Postsurgical sequential methotrexate, fluorouracil, and leucovorin for advanced colorectal carcinoma: a preliminary study.
    Journal of surgical oncology, 1997, Volume: 66, Issue:1

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Disease-Free Survival; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Mitomycin; Postoperative Period; Rectal Neoplasms; Survival Rate; Tegafur; Uracil

1997
Scientific basis for the combination of tegafur with uracil.
    Oncology (Williston Park, N.Y.), 1997, Volume: 11, Issue:9 Suppl 10

    Topics: Chemotherapy, Adjuvant; Dose-Response Relationship, Drug; Drug Combinations; Female; Fluorouracil; Gastrectomy; Humans; Intestinal Absorption; Male; Middle Aged; Mitomycin; Postoperative Care; Stomach Neoplasms; Survival Analysis; Tegafur; Uracil

1997
Phase I and pharmacokinetic evaluations of UFT plus oral leucovorin.
    Oncology (Williston Park, N.Y.), 1997, Volume: 11, Issue:9 Suppl 10

    Topics: Administration, Oral; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase I as Topic; Drug Combinations; Fluorouracil; Humans; Leucovorin; Neoplasms; Tegafur; Tetrahydrofolates; Uracil

1997
5-FU or UFT combined with leucovorin for previously untreated metastatic colorectal Ca.
    Oncology (Williston Park, N.Y.), 1997, Volume: 11, Issue:9 Suppl 10

    Topics: Adult; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Combinations; Drug Therapy, Combination; Fluorouracil; Humans; Leucovorin; Tegafur; Uracil

1997
UFT plus leucovorin vs 5-FU plus leucovorin for metastatic colorectal cancer.
    Oncology (Williston Park, N.Y.), 1997, Volume: 11, Issue:9 Suppl 10

    Topics: Adult; Aged; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Combinations; Drug Therapy, Combination; Fluorouracil; Humans; Leucovorin; Middle Aged; Tegafur; Uracil

1997
Preoperative combined oral UFT plus leucovorin and radiation therapy for rectal cancer.
    Oncology (Williston Park, N.Y.), 1997, Volume: 11, Issue:9 Suppl 10

    Topics: Antidotes; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Drug Combinations; Feasibility Studies; Fluorouracil; Humans; Leucovorin; Radiotherapy Dosage; Rectal Neoplasms; Tegafur; Uracil

1997
UFT in combination as adjuvant therapy for breast cancer. Grupo Oncologico de Sevilla Seville, Spain.
    Oncology (Williston Park, N.Y.), 1997, Volume: 11, Issue:9 Suppl 10

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Drug Combinations; Female; Fluorouracil; Humans; Methotrexate; Middle Aged; Postmenopause; Prednimustine; Premenopause; Spain; Survival Analysis; Tamoxifen; Tegafur; Uracil

1997
Neoadjuvant therapy with cisplatin/fluorouracil vs cisplatin/UFT in locally advanced squamous cell head and neck cancer.
    Oncology (Williston Park, N.Y.), 1997, Volume: 11, Issue:9 Suppl 10

    Topics: Adult; Aged; Alopecia; Anemia; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Cisplatin; Diarrhea; Drug Combinations; Female; Fluorouracil; Forecasting; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Staging; Neutropenia; Prospective Studies; Survival Rate; Tegafur; Treatment Outcome; Uracil

1997
[Phase I study of S-1. S-1 Study Group].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:15

    Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Oxonic Acid; Pyridines; Tegafur

1997
Phase III randomized comparison of postoperative adjuvant chemotherapy with 2-year oral UFT (uracil/tegafur) versus six-cycle CMF (cyclophosphamide/methotrexate/5-fluorouracil) in high-risk node-negative breast cancer patients.
    Japanese journal of clinical oncology, 1998, Volume: 28, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Disease-Free Survival; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Methotrexate; Middle Aged; Tegafur; Uracil

1998
A crossover study of oral administration of UFT in chronic liver disease: comparison of continuous and intermittent schedules.
    Anti-cancer drugs, 1998, Volume: 9, Issue:5

    Topics: Administration, Oral; Aged; Area Under Curve; Carcinoma, Hepatocellular; Chronic Disease; Cross-Over Studies; Diarrhea; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Gastritis; Gastrointestinal Hemorrhage; Humans; Liver Diseases; Liver Neoplasms; Male; Middle Aged; Nausea; Tegafur; Treatment Outcome; Uracil

1998
Effects of pharmacokinetic modulating chemotherapy using oral UFT and continuous venous 5FU infusion on the prognosis of irradiated rectal carcinomas with p53 overexpression.
    International journal of oncology, 1998, Volume: 13, Issue:4

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Combined Modality Therapy; Drug Therapy, Combination; Female; Fluorouracil; Follow-Up Studies; Humans; Immunohistochemistry; Infusions, Intravenous; Male; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Prospective Studies; Rectal Neoplasms; Survival Rate; Tegafur; Treatment Outcome; Tumor Suppressor Protein p53

1998
Phase III randomized comparison of postoperative adjuvant chemotherapy with 2-year oral uracil/tegafur versus 6-cycle cyclophosphamide/methotrexate/5-fluorouracil in high-risk node-negative breast cancer patients.
    Cancer chemotherapy and pharmacology, 1998, Volume: 42 Suppl

    Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Female; Fluorouracil; Humans; Methotrexate; Middle Aged; Risk; Survival Analysis; Tegafur; Uracil

1998
Potential of the histoculture drug-response assay to contribute to cancer patient survival.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1995, Volume: 1, Issue:12

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Drug Combinations; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Male; Middle Aged; Mitomycin; Multivariate Analysis; Prospective Studies; Stomach Neoplasms; Survival Rate; Tegafur; Tumor Stem Cell Assay; Uracil

1995
Phase I and pharmacokinetic study of oral UFT, a combination of the 5-fluorouracil prodrug tegafur and uracil.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1996, Volume: 2, Issue:9

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Area Under Curve; Cohort Studies; Diarrhea; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Fatigue; Female; Fluorouracil; Humans; Male; Middle Aged; Nausea; Prodrugs; Tegafur; Uracil; Vomiting

1996
[A study on the efficacy of combination chemoendocrine therapy consisting of cyclophosphamide, adriamycin, UFT, and tamoxifen for advanced or recurrent breast cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1999, Volume: 26, Issue:8

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Humans; Middle Aged; Neoplasm Recurrence, Local; Survival Rate; Tamoxifen; Tegafur; Treatment Outcome

1999
Adjuvant mitomycin and fluorouracil followed by oral uracil plus tegafur in serosa-negative gastric cancer: a randomised trial. Gastric Cancer Surgical Study Group.
    Lancet (London, England), 1999, Jul-24, Volume: 354, Issue:9175

    Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Female; Fluorouracil; Gastrectomy; Humans; Infusions, Intravenous; Male; Middle Aged; Mitomycins; Stomach Neoplasms; Survival Rate; Tegafur; Uracil

1999
Impact of uracil/tegafur plus oral calcium folinate on resource utilization.
    Oncology (Williston Park, N.Y.), 1999, Volume: 13, Issue:7 Suppl 3

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Fluorouracil; Health Resources; Health Services; Health Services Research; Hospitalization; Humans; Leucovorin; Outpatients; Tegafur; Uracil

1999
UFT plus calcium folinate vs 5-FU plus calcium folinate in colon cancer.
    Oncology (Williston Park, N.Y.), 1999, Volume: 13, Issue:7 Suppl 3

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Disease-Free Survival; Drug Therapy, Combination; Female; Fluorouracil; Follow-Up Studies; Humans; Leucovorin; Male; Middle Aged; Prospective Studies; Survival Rate; Tegafur; Treatment Outcome; Uracil

1999
Using preoperative UFT to predict sensitivity to fluoropyrimidines in colorectal cancer.
    Oncology (Williston Park, N.Y.), 1999, Volume: 13, Issue:7 Suppl 3

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colectomy; Colonoscopy; Colorectal Neoplasms; Disease-Free Survival; Drug Hypersensitivity; Fluorouracil; Humans; Necrosis; Neoplasm Staging; Preoperative Care; Prospective Studies; Survival Rate; Tegafur; Treatment Outcome; Uracil

1999
An early phase II study of oral S-1, a newly developed 5-fluorouracil derivative for advanced and recurrent gastrointestinal cancers. The S-1 Gastrointestinal Cancer Study Group.
    Oncology, 1999, Volume: 57, Issue:3

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Drug Combinations; Fluorouracil; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Oxonic Acid; Pyridines; Survival Analysis; Tegafur; Treatment Outcome

1999
[Clinical trial of prophylactic hepatic arterial chemotherapy for liver metastases in patients with Dukes' C colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1999, Volume: 26, Issue:12

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration Schedule; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Neoplasm Staging; Prospective Studies; Tegafur; Uracil

1999
[Usefulness of pharmacokinetic modulating chemotherapy (PMC) for the postoperative adjuvant therapy of colorectal carcinoma: a preliminary report].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1999, Volume: 26, Issue:14

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Prognosis; Random Allocation; Tegafur; Uracil

1999
Prognosis after salvage chemotherapy for locally unresectable recurrent squamous cell carcinoma of the head and neck.
    Japanese journal of clinical oncology, 1999, Volume: 29, Issue:10

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Drug Administration Schedule; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Salvage Therapy; Survival Rate; Tegafur; Uracil

1999
[Interim report of JFMTC study no. 20 on the effectiveness of high dose CDDP plus 5-FU regimen as an adjuvant therapy for far-advanced cancer of the stomach].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Drug Evaluation; Fluorouracil; Humans; Stomach Neoplasms; Survival Rate; Tegafur; Uracil

2000
Phase II study of S-1, a novel oral derivative of 5-fluorouracil, in advanced gastric cancer. For the S-1 Cooperative Gastric Cancer Study Group.
    Oncology, 2000, Volume: 58, Issue:3

    Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Oxonic Acid; Pyridines; Stomach Neoplasms; Tegafur; Treatment Outcome

2000
Preoperative UFT administration for patients with advanced colorectal cancer--increased uptake of 5-fluorouracil by tumor tissue is a prognostic factor.
    Anti-cancer drugs, 2000, Volume: 11, Issue:3

    Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Colorectal Neoplasms; Female; Fluorouracil; Humans; Japan; Male; Middle Aged; Neoplasm Staging; Preoperative Care; Prognosis; Prospective Studies; Regression Analysis; Survival Analysis; Tegafur

2000
[Randomized comparative study of CMF (cyclophosphamide, methotrexate and 5-fluorouracil) and UFT-tamoxifen regimens as adjuvant chemotherapy after surgery for breast cancer: Tochigi Prefectural Study Group for Post-Breast Cancer Adjuvant Chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:7

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Drug Administration Schedule; Female; Fluorouracil; Humans; Lymphatic Metastasis; Methotrexate; Middle Aged; Prospective Studies; Quality of Life; Survival Rate; Tamoxifen; Tegafur; Uracil

2000
Results of pharmacokinetic modulating chemotherapy in combination with hepatic arterial 5-fluorouracil infusion and oral UFT after resection of hepatic colorectal metastases.
    Cancer, 2000, Sep-15, Volume: 89, Issue:6

    Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Synergism; Female; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Prospective Studies; Survival Analysis; Tegafur; Treatment Outcome; Uracil

2000
UFT/leucovorin vs 5-FU/leucovorin in colon cancer.
    Oncology (Williston Park, N.Y.), 2000, Volume: 14, Issue:10 Suppl 9

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Disease-Free Survival; Drug Therapy, Combination; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Tegafur; Treatment Outcome; Uracil

2000
Effect of food on the oral bioavailability of UFT and leucovorin in cancer patients.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:3

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Biological Availability; Colorectal Neoplasms; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Combinations; Fasting; Female; Fluorouracil; Food; Humans; Leucovorin; Male; Middle Aged; Tegafur; Tetrahydrofolates; Time Factors; Uracil

2001
Patient preference and pharmacokinetics of oral modulated UFT versus intravenous fluorouracil and leucovorin: a randomised crossover trial in advanced colorectal cancer.
    European journal of cancer (Oxford, England : 1990), 2002, Volume: 38, Issue:3

    Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Cross-Over Studies; Female; Fluorouracil; Humans; Injections, Intravenous; Leucovorin; Male; Middle Aged; Patient Satisfaction; Prospective Studies; Surveys and Questionnaires; Tegafur; Uracil

2002
Oral fluoropyrimidines in the treatment of advanced colorectal cancer--results of two consecutive phase II trials.
    Acta oncologica (Stockholm, Sweden), 2002, Volume: 41, Issue:2

    Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Diarrhea; Drug Combinations; Fluorouracil; Humans; Leucovorin; Nausea; Survival Rate; Tegafur; Time Factors; Uracil

2002
Clinical studies of three oral prodrugs of 5-fluorouracil (capecitabine, UFT, S-1): a review.
    The oncologist, 2002, Volume: 7, Issue:4

    Topics: Administration, Oral; Antineoplastic Agents; Capecitabine; Deoxycytidine; Fluorouracil; Humans; Neoplasms; Prodrugs; Pyridines; Tegafur; Treatment Outcome; Uracil

2002
Multicenter phase III study of uracil/tegafur and oral leucovorin versus fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Sep-01, Volume: 20, Issue:17

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Quality of Life; Survival Rate; Tegafur; United States; Uracil

2002
Randomized comparative study of tegafur/uracil and oral leucovorin versus parenteral fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Sep-01, Volume: 20, Issue:17

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease-Free Survival; Dose-Response Relationship, Drug; Europe; Female; Fluorouracil; Humans; Infusions, Parenteral; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Quality of Life; Survival Rate; Tegafur; Uracil

2002
[Hepatic recurrence after prophylactic hepatic arterial infusion of 5-fluorouracil for Dukes' C colorectal cancer--correlation with the expression of dihydropyrimidine dehydrogenase in the primary tumor].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:12

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dihydrouracil Dehydrogenase (NADP); Enzyme-Linked Immunosorbent Assay; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Neoplasm Recurrence, Local; Oxidoreductases; Tegafur; Uracil

2002
Randomized phase III trial of fluorouracil alone versus fluorouracil plus cisplatin versus uracil and tegafur plus mitomycin in patients with unresectable, advanced gastric cancer: The Japan Clinical Oncology Group Study (JCOG9205).
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jan-01, Volume: 21, Issue:1

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Disease-Free Survival; Female; Fluorouracil; Humans; Japan; Male; Middle Aged; Mitomycin; Prospective Studies; Stomach Neoplasms; Survival Rate; Tegafur; Uracil

2003
[Interim report of JFMC study no. 23--phase III randomized clinical trial on the effectiveness of low-dose cisplatin plus 5-FU as a postoperative adjuvant chemotherapy for advanced gastric cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:13

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Disease-Free Survival; Drug Administration Schedule; Female; Fluorouracil; Humans; Male; Middle Aged; Stomach Neoplasms; Survival Rate; Tegafur

2002
Pharmacokinetics of S-1, an oral formulation of ftorafur, oxonic acid and 5-chloro-2,4-dihydroxypyridine (molar ratio 1:0.4:1) in patients with solid tumors.
    Cancer chemotherapy and pharmacology, 2003, Volume: 52, Issue:1

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Area Under Curve; Biological Availability; Dose-Response Relationship, Drug; Drug Combinations; Female; Fluorouracil; Half-Life; Humans; Male; Metabolic Clearance Rate; Middle Aged; Neoplasms; Oxonic Acid; Pyridines; Tegafur; Tissue Distribution; Uracil

2003
Modelling of ftorafur and 5-fluorouracil pharmacokinetics following oral UFT administration. A population study in 30 patients with advanced breast cancer.
    Cancer chemotherapy and pharmacology, 2003, Volume: 52, Issue:2

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Middle Aged; Models, Biological; Neoplasm Metastasis; Tegafur; Uracil; Vinblastine; Vinorelbine

2003
A new regimen for S-1 therapy aiming at adverse reaction mitigation and prolonged medication by introducing a 1-week drug-free interval after each 2-week dosing session: efficacy and feasibility in clinical practice.
    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2003, Volume: 6 Suppl 1

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Feasibility Studies; Female; Fluorouracil; Follow-Up Studies; Humans; Japan; Male; Middle Aged; Neoplasm Recurrence, Local; Oxonic Acid; Patient Compliance; Pyridines; Retrospective Studies; Severity of Illness Index; Stomach Neoplasms; Tegafur; Time Factors; Treatment Outcome

2003
Prediction of sensitivity to fluoropyrimidines by metabolic and target enzyme activities in gastric cancer.
    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2003, Volume: 6 Suppl 1

    Topics: Adult; Aged; Aged, 80 and over; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Combined Modality Therapy; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Female; Fluorouracil; Gastrectomy; Humans; Japan; Liver Neoplasms; Lymphatic Metastasis; Male; Mice; Mice, Inbred BALB C; Middle Aged; Multivariate Analysis; Neoplasm Staging; Oxidoreductases; Oxonic Acid; Peritoneal Neoplasms; Predictive Value of Tests; Pyridines; Retrospective Studies; Statistics as Topic; Stomach Neoplasms; Survival Analysis; Tegafur; Thymidine Phosphorylase; Thymidylate Synthase; Treatment Outcome; Uracil

2003
Oral tegafur-uracil plus folinic acid versus intravenous 5-fluorouracil plus folinic acid as adjuvant chemotherapy of colon cancer.
    Yonsei medical journal, 2003, Aug-30, Volume: 44, Issue:4

    Topics: Adenocarcinoma; Administration, Oral; Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Colonic Neoplasms; Drug Therapy, Combination; Female; Fluorouracil; Humans; Injections, Intravenous; Leucovorin; Male; Middle Aged; Tegafur

2003
[Preoperative chemoradiotherapy for locally advanced rectal cancer].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 7

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Colectomy; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Preoperative Care; Prognosis; Radiotherapy, Adjuvant; Radiotherapy, Conformal; Rectal Neoplasms; Suppositories; Tegafur

2003
Randomized controlled trial of the efficacy of adjuvant immunochemotherapy and adjuvant chemotherapy for colorectal cancer, using different combinations of the intracutaneous streptococcal preparation OK-432 and the oral pyrimidines 1-hexylcarbamoyl-5-flu
    International journal of clinical oncology, 2004, Volume: 9, Issue:2

    Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colectomy; Colonic Neoplasms; Drug Combinations; Female; Fluorouracil; Humans; Injections, Subcutaneous; Male; Middle Aged; Mitomycin; Neoplasm Staging; Picibanil; Pyrimidines; Radiotherapy, Adjuvant; Rectal Neoplasms; Survival Analysis; Tegafur; Treatment Outcome; Uracil

2004
The effect of food on the pharmacokinetics of S-1 after single oral administration to patients with solid tumors.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Jun-15, Volume: 10, Issue:12 Pt 1

    Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Biological Availability; Cross-Over Studies; Eating; Female; Fluorouracil; Food; Humans; Kinetics; Male; Middle Aged; Neoplasms; Oxonic Acid; Phosphorylation; Pyridines; Tegafur; Time Factors

2004
Concurrent and adjuvant chemotherapy for nasopharyngeal carcinoma: a factorial study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Jul-01, Volume: 22, Issue:13

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Disease-Free Survival; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Methotrexate; Middle Aged; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Tegafur; Treatment Outcome; Uracil; Vincristine

2004
Enhanced induction of apoptosis in lung adenocarcinoma after preoperative chemotherapy with tegafur and uracil (UFT).
    Surgery today, 2004, Volume: 34, Issue:10

    Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Chemotherapy, Adjuvant; Drug Therapy, Combination; Female; Fluorouracil; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Lung Neoplasms; Male; Middle Aged; Preoperative Care; Prospective Studies; Tegafur; Uracil

2004
Docetaxel (Taxotere), cisplatin, UFT, and leucovorin combination chemotherapy in advanced gastric cancer.
    British journal of cancer, 2005, Mar-14, Volume: 92, Issue:5

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Docetaxel; Drug Combinations; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Staging; Stomach Neoplasms; Survival Analysis; Taxoids; Tegafur; Treatment Outcome; Uracil

2005
Randomized crossover trial of intravenous 5-FU versus oral UFT both modulated by leucovorin: a one-centre experience.
    European journal of cancer care, 2005, Volume: 14, Issue:2

    Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Cross-Over Studies; Female; Fluorouracil; Humans; Injections, Intravenous; Leucovorin; Male; Patient Satisfaction; Prospective Studies; Tegafur; Uracil

2005
Phase II study of irinotecan, leucovorin, 5-fluorouracil and tegafur/uracil for metastatic colorectal cancer.
    Journal of chemotherapy (Florence, Italy), 2005, Volume: 17, Issue:2

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluorouracil; Follow-Up Studies; Humans; Irinotecan; Leucovorin; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Palliative Care; Survival Analysis; Tegafur; Treatment Outcome; Uracil

2005
[Pharmacokinetic modulating chemotherapy highly effective for colorectal carcinoma metastases to multiple organs].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:6

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Chronotherapy; Colorectal Neoplasms; Drug Combinations; Female; Fluorouracil; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Lung Neoplasms; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Tegafur; Uracil

2005
[Phase I study of concurrent radiotherapy with TS-1 and vitamin A (TAR Therapy) for head and neck cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:6

    Topics: Adult; Aged; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Drug Administration Schedule; Drug Combinations; Fluorouracil; Head and Neck Neoplasms; Humans; Maximum Tolerated Dose; Middle Aged; Oxonic Acid; Pyridines; Quality of Life; Radiotherapy Dosage; Tegafur; Vitamin A

2005
[Multicenter comparative study of the recurrence-inhibitory effect of oral fluoropyrimidine drugs in patients with colorectal cancer following curative resection].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:7

    Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Colectomy; Colonic Neoplasms; Combined Modality Therapy; Disease-Free Survival; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Leukopenia; Lymphatic Metastasis; Male; Middle Aged; Mitomycin; Rectal Neoplasms; Survival Rate; Tegafur; Uracil

2005
[Clinical evaluation of chemotherapy with irinotecan (CPT-11), l-leucovorin (l-LV), 5-fluorouracil (5-FU), and UFT for metastatic or recurrent colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:9

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Male; Middle Aged; Nausea; Rectal Neoplasms; Survival Rate; Tegafur; Uracil; Vomiting, Anticipatory

2005
Randomised study of tegafur and oral leucovorin versus intravenous 5-fluorouracil and leucovorin in patients with advanced colorectal cancer.
    European journal of cancer (Oxford, England : 1990), 2005, Volume: 41, Issue:15

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Survival Analysis; Tegafur; Treatment Outcome

2005
Oral uracil and tegafur plus leucovorin compared with intravenous fluorouracil and leucovorin in stage II and III carcinoma of the colon: results from National Surgical Adjuvant Breast and Bowel Project Protocol C-06.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, May-01, Volume: 24, Issue:13

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Disease-Free Survival; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Staging; Neoplasms, Second Primary; Quality of Life; Tegafur; Uracil

2006
Diverticular disease in patients with colon cancer: subgroup analysis of national surgical adjuvant breast and bowel project protocol C-06.
    Clinical colorectal cancer, 2006, Volume: 6, Issue:2

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Cohort Studies; Colonic Neoplasms; Diverticulum, Colon; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Staging; Prognosis; Retrospective Studies; Tegafur

2006
[A randomized controlled study comparing uracil-tegafur (UFT)+tamoxifen (UFT+TAM therapy) with cyclophosphamide+adriamycin+5-fluorouracil (CAF therapy) for women with stage I , II, or IIIa breast cancer with four or more involved nodes in the adjuvant set
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:10

    Topics: Anorexia; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Fluorouracil; Humans; Leukopenia; Lymph Nodes; Lymphatic Metastasis; Mastectomy; Middle Aged; Neoplasm Staging; Survival Rate; Tamoxifen; Tegafur; Uracil; Vomiting, Anticipatory

2006
Biweekly oxaliplatin plus 1-day infusional fluorouracil/leucovorin followed by metronomic chemotherapy with tegafur/uracil in pretreated metastatic colorectal cancer.
    Cancer chemotherapy and pharmacology, 2007, Volume: 60, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration Schedule; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Patient Selection; Survival Analysis; Tegafur; Uracil

2007
Quality of life in operable colon cancer patients receiving oral compared with intravenous chemotherapy: results from National Surgical Adjuvant Breast and Bowel Project Trial C-06.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Feb-01, Volume: 25, Issue:4

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Female; Fluorouracil; Health Status; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Quality of Life; Tegafur; Uracil

2007
A randomized phase II selection trial in patients with advanced/recurrent gastric cancer: Trial for Advanced Stomach Cancer (TASC).
    Japanese journal of clinical oncology, 2007, Volume: 37, Issue:6

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Fluorouracil; Humans; Neoplasm Recurrence, Local; Oxonic Acid; Paclitaxel; Stomach Neoplasms; Tegafur

2007
Development of a pharmacokinetic model to optimize the dosage regimen of TS-1, a combination preparation of tegafur, gimeracil and oteracil potassium.
    Drug metabolism and pharmacokinetics, 2007, Volume: 22, Issue:3

    Topics: Administration, Oral; Algorithms; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Computer Simulation; Drug Combinations; Fluorouracil; Humans; Kidney; Kinetics; Models, Biological; Oxonic Acid; Pyridines; Renal Insufficiency; Tegafur; Time Factors; Uracil

2007
Chronopharmacokinetics of oral tegafur and uracil in colorectal cancer patients.
    Clinical pharmacology and therapeutics, 2008, Volume: 83, Issue:3

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Chronotherapy; Colorectal Neoplasms; Cross-Over Studies; Female; Fluorouracil; Humans; Male; Middle Aged; Tegafur; Therapeutic Equivalency; Uracil

2008
Relationship between expression of vascular endothelial growth factor in tumor tissue from gastric cancers and chemotherapy effects: comparison between S-1 alone and the combination of S-1 plus CDDP.
    Japanese journal of clinical oncology, 2007, Volume: 37, Issue:7

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Cisplatin; Drug Combinations; Fluorouracil; Humans; Immunohistochemistry; Middle Aged; Oxonic Acid; Stomach Neoplasms; Tegafur; Vascular Endothelial Growth Factor A

2007
Effect of gastrectomy on the pharmacokinetics of S-1, an oral fluoropyrimidine, in resectable gastric cancer patients.
    Cancer chemotherapy and pharmacology, 2007, Volume: 60, Issue:5

    Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Drug Combinations; Female; Fluorouracil; Gastrectomy; Humans; Male; Middle Aged; Oxonic Acid; Pyridines; Stomach Neoplasms; Tegafur

2007
Preoperative chemoradiotherapy for rectal cancer: randomized trial comparing oral uracil and tegafur and oral leucovorin vs. intravenous 5-fluorouracil and leucovorin.
    International journal of radiation oncology, biology, physics, 2008, Jan-01, Volume: 70, Issue:1

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Disease-Free Survival; Drug Administration Schedule; Female; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Neoplasm Staging; Preoperative Care; Prospective Studies; Radiotherapy Dosage; Rectal Neoplasms; Survival Analysis; Tegafur; Uracil; Vitamin B Complex

2008
Randomized phase II study of cisplatin and 5-FU continuous infusion (PF) versus cisplatin, UFT and vinorelbine (UFTVP) as induction chemotherapy in locally advanced squamous cell head and neck cancer (LA-SCHNC).
    Cancer chemotherapy and pharmacology, 2008, Volume: 62, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Disease-Free Survival; Fluorouracil; Head and Neck Neoplasms; Humans; Infusions, Intravenous; Middle Aged; Neoplasm Invasiveness; Proportional Hazards Models; Tegafur; Uracil; Vinblastine; Vinorelbine

2008
Improved survival for hepatocellular carcinoma with portal vein tumor thrombosis treated by intra-arterial chemotherapy combining etoposide, carboplatin, epirubicin and pharmacokinetic modulating chemotherapy by 5-FU and enteric-coated tegafur/uracil: a p
    World journal of gastroenterology, 2007, Nov-07, Volume: 13, Issue:41

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Hepatocellular; Chemotherapy, Cancer, Regional Perfusion; Epirubicin; Etoposide; Female; Fluorouracil; Humans; Infusions, Intra-Arterial; Kaplan-Meier Estimate; Liver Neoplasms; Male; Middle Aged; Neoplasm Staging; Pilot Projects; Portal Vein; Prospective Studies; Severity of Illness Index; Tablets, Enteric-Coated; Tegafur; Time Factors; Treatment Outcome; Uracil; Venous Thrombosis

2007
A clinical pharmacokinetic analysis of tegafur-uracil (UFT) plus leucovorin given in a new twice-daily oral administration schedule.
    Clinical pharmacokinetics, 2007, Volume: 46, Issue:11

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Cross-Over Studies; Diarrhea; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Prodrugs; Sex Factors; Tegafur; Therapeutic Equivalency; Uracil

2007
An anticancer drug sensitivity test to determine the effectiveness of UFT as postoperative adjuvant chemotherapy for patients with stage III colorectal cancer.
    Surgery, 2007, Volume: 142, Issue:5

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Colorectal Neoplasms; Combined Modality Therapy; Disease-Free Survival; Drug Combinations; Drug Resistance, Neoplasm; Female; Fluorouracil; Follow-Up Studies; Humans; Male; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local; Neoplasm Staging; Postoperative Period; Survival Rate; Tegafur; Uracil

2007
[Neoadjuvant chemotherapy for gastric cancer with peritoneal dissemination].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:12

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Docetaxel; Drug Combinations; Female; Fluorouracil; Follow-Up Studies; Humans; Male; Middle Aged; Neoadjuvant Therapy; Oxonic Acid; Peritoneal Neoplasms; Stomach Neoplasms; Survival Rate; Taxoids; Tegafur

2007
Effectiveness of pharmacokinetic modulating chemotherapy combined with cisplatin as induction chemotherapy in resectable locally advanced head and neck cancer: phase II study.
    Cancer chemotherapy and pharmacology, 2008, Volume: 63, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Disease-Free Survival; Drug Administration Schedule; Female; Fluorouracil; Follow-Up Studies; Gastrointestinal Diseases; Head and Neck Neoplasms; Hematologic Diseases; Humans; Leucovorin; Male; Middle Aged; Radiotherapy, Adjuvant; Remission Induction; Salvage Therapy; Survival Analysis; Tegafur; Treatment Outcome; Uracil

2008
CYP2A6 and the plasma level of 5-chloro-2, 4-dihydroxypyridine are determinants of the pharmacokinetic variability of tegafur and 5-fluorouracil, respectively, in Japanese patients with cancer given S-1.
    Cancer science, 2008, Volume: 99, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Aryl Hydrocarbon Hydroxylases; Asian People; Cytochrome P-450 CYP2A6; Drug Combinations; Female; Fluorouracil; Genotype; Humans; Male; Middle Aged; Mixed Function Oxygenases; Neoplasms; Oxonic Acid; Polymorphism, Genetic; Pyridines; Tegafur

2008
A randomised multicentre phase II trial of capecitabine vs S-1 as first-line treatment in elderly patients with metastatic or recurrent unresectable gastric cancer.
    British journal of cancer, 2008, Aug-19, Volume: 99, Issue:4

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Bone Neoplasms; Capecitabine; Deoxycytidine; Drug Combinations; Feasibility Studies; Female; Fluorouracil; Humans; Liver Neoplasms; Lymphatic Metastasis; Male; Neoplasm Recurrence, Local; Oxonic Acid; Peritoneal Neoplasms; Prognosis; Stomach Neoplasms; Survival Rate; Tegafur; Treatment Outcome

2008
[Curative effects of FTQ combined with cisplatin in treatment of advanced gastric cancer: a multicenter study].
    Zhonghua yi xue za zhi, 2008, May-27, Volume: 88, Issue:20

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Fluorouracil; Humans; Middle Aged; Oxonic Acid; Pyridines; Single-Blind Method; Stomach Neoplasms; Tegafur; Treatment Outcome

2008
Phase II study of UFT with leucovorin plus hepatic arterial infusion with irinotecan, 5-fluorouracil and leucovorin for non-resectable liver metastases of colorectal cancer.
    Chemotherapy, 2009, Volume: 55, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Male; Middle Aged; Tegafur; Uracil

2009
Phase I and pharmacokinetic study of tegafur-uracil/leucovorin combined with 5-fluorouracil/leucovorin and irinotecan in patients with advanced colorectal cancer.
    American journal of clinical oncology, 2009, Volume: 32, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Camptothecin; Colorectal Neoplasms; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Maximum Tolerated Dose; Middle Aged; Prognosis; Survival Rate; Tegafur; Tissue Distribution; Treatment Outcome

2009
Oral uracil and tegafur compared with classic cyclophosphamide, methotrexate, fluorouracil as postoperative chemotherapy in patients with node-negative, high-risk breast cancer: National Surgical Adjuvant Study for Breast Cancer 01 Trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Mar-20, Volume: 27, Issue:9

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Female; Fluorouracil; Humans; Lymphatic Metastasis; Methotrexate; Middle Aged; Neoplasm Staging; Quality of Life; Risk Factors; Tegafur; Uracil

2009
Impacts of fluorouracil-metabolizing enzymes on the outcomes of patients treated with S-1 alone or S-1 plus cisplatin for first-line treatment of advanced gastric cancer.
    International journal of cancer, 2010, Jan-01, Volume: 126, Issue:1

    Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Combinations; Enzymes; Female; Fluorouracil; Humans; Male; Middle Aged; Oxonic Acid; Stomach Neoplasms; Survival Analysis; Tegafur; Treatment Outcome

2010
Uracil-tegafur and tamoxifen vs cyclophosphamide, methotrexate, fluorouracil, and tamoxifen in post-operative adjuvant therapy for stage I, II, or IIIA lymph node-positive breast cancer: a comparative study.
    British journal of cancer, 2009, Aug-18, Volume: 101, Issue:4

    Topics: Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Cyclophosphamide; Disease-Free Survival; Female; Fluorouracil; Humans; Lymphatic Metastasis; Mastectomy; Methotrexate; Middle Aged; Neoplasm Staging; Survival Rate; Tamoxifen; Tegafur; Uracil

2009
Phase II study of S-1 combined with irinotecan (CPT-11) in patients with advanced colorectal cancer.
    Oncology, 2009, Volume: 77, Issue:3-4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Female; Fluorouracil; Humans; Irinotecan; Male; Middle Aged; Oxonic Acid; Tegafur

2009
Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study.
    The Lancet. Oncology, 2009, Volume: 10, Issue:11

    Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Disease-Free Survival; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Infusions, Intravenous; Irinotecan; Japan; Male; Middle Aged; Oxonic Acid; Proportional Hazards Models; Risk Assessment; Stomach Neoplasms; Tegafur; Time Factors; Treatment Outcome; Young Adult

2009
Efficacy of oral tegafur-uracil (UFT) as adjuvant therapy as compared with classical cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) in early breast cancer: a pooled analysis of two randomized controlled trials (N.SAS-BC 01 trial and CUBC trial).
    Breast cancer research and treatment, 2010, Volume: 119, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Disease-Free Survival; Female; Fluorouracil; Humans; Methotrexate; Middle Aged; Neoplasm Staging; Receptors, Estrogen; Tegafur; Uracil; Young Adult

2010
[Effects of pharmacokinetic modulation chemotherapy (PMC) using oral UFT and venous 5-FU infusion as adjuvant chemotherapy for intrahepatic cholangiocellular carcinoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:12

    Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Chemotherapy, Adjuvant; Cholangiocarcinoma; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Survival Rate; Tegafur; Uracil

2009
Multicenter phase III comparison of cisplatin/S-1 with cisplatin/infusional fluorouracil in advanced gastric or gastroesophageal adenocarcinoma study: the FLAGS trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Mar-20, Volume: 28, Issue:9

    Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Combinations; Esophageal Neoplasms; Female; Fluorouracil; Humans; Male; Middle Aged; Oxonic Acid; Stomach Neoplasms; Survival Analysis; Tegafur; Treatment Outcome; Young Adult

2010
Phase I/II study of irinotecan, UFT and leucovorin with hepatic arterial infusion using 5-FU in colorectal cancer patients with unresectable liver metastases.
    Cancer chemotherapy and pharmacology, 2011, Volume: 67, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Fluorouracil; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Survival Rate; Tegafur; Treatment Outcome; Uracil

2011
Pharmacokinetics of S-1 and CYP2A6 genotype in Japanese patients with advanced cancer.
    Oncology reports, 2010, Volume: 24, Issue:2

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Asian People; Cytochrome P-450 CYP2A6; Disease Progression; Drug Combinations; Female; Fluorouracil; Genotype; Humans; Male; Metabolic Clearance Rate; Middle Aged; Neoplasms; Oxonic Acid; Pharmacogenetics; Tegafur

2010
Irinotecan plus S-1 (IRIS) versus fluorouracil and folinic acid plus irinotecan (FOLFIRI) as second-line chemotherapy for metastatic colorectal cancer: a randomised phase 2/3 non-inferiority study (FIRIS study).
    The Lancet. Oncology, 2010, Volume: 11, Issue:9

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Disease-Free Survival; Drug Combinations; Female; Fluorouracil; Humans; Irinotecan; Kaplan-Meier Estimate; Leucovorin; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Prodrugs; Tegafur

2010
A pilot study of S-1 plus cisplatin versus 5-fluorouracil plus cisplatin for postoperative chemotherapy in histological stage IIIB-IV (M0) gastric cancer.
    Investigational new drugs, 2012, Volume: 30, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Chi-Square Distribution; Cisplatin; Disease-Free Survival; Drug Combinations; Feasibility Studies; Female; Fluorouracil; Gastrectomy; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Staging; Oxonic Acid; Pilot Projects; Republic of Korea; Stomach Neoplasms; Tegafur; Time Factors; Treatment Outcome

2012
Phase I study of S-1 plus nedaplatin in patients with advanced/recurrent head and neck cancer.
    Chemotherapy, 2010, Volume: 56, Issue:6

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Carcinoma, Squamous Cell; Cisplatin; Disease Progression; Drug Combinations; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Recurrence, Local; Neoplasms, Squamous Cell; Organoplatinum Compounds; Oxonic Acid; Squamous Cell Carcinoma of Head and Neck; Tegafur

2010
Phase II study of combination chemotherapy with biweekly cetuximab and irinotecan for wild-type KRAS metastatic colorectal cancer refractory to irinotecan, oxaliplatin, and fluoropyrimidines.
    Investigational new drugs, 2012, Volume: 30, Issue:2

    Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cetuximab; Colorectal Neoplasms; Disease Progression; Disease-Free Survival; Drug Administration Schedule; Drug Combinations; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Infusions, Intravenous; Irinotecan; Japan; Kaplan-Meier Estimate; Male; Middle Aged; Mutation; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Prospective Studies; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Tegafur; Treatment Failure

2012
A phase I study evaluating the effect of CDHP as a component of S-1 on the pharmacokinetics of 5-fluorouracil.
    Anticancer research, 2011, Volume: 31, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cross-Over Studies; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Drug Interactions; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Oxonic Acid; Pyridines; Tegafur

2011
Modified FOLFOX6 with oxaliplatin stop-and-go strategy and oral S-1 maintenance therapy in advanced colorectal cancer: CCOG-0704 study.
    International journal of clinical oncology, 2011, Volume: 16, Issue:5

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease-Free Survival; Drug Combinations; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Tegafur

2011
Phase 1 trial of S-1 in combination with sorafenib for patients with advanced hepatocellular carcinoma.
    Investigational new drugs, 2012, Volume: 30, Issue:4

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzenesulfonates; Carcinoma, Hepatocellular; Drug Combinations; Female; Fluorouracil; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Liver Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Staging; Niacinamide; Oxonic Acid; Phenylurea Compounds; Pyridines; Sorafenib; Tegafur; Treatment Outcome

2012
Phenylbutyrate mouthwash mitigates oral mucositis during radiotherapy or chemoradiotherapy in patients with head-and-neck cancer.
    International journal of radiation oncology, biology, physics, 2012, Mar-15, Volume: 82, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Cisplatin; Double-Blind Method; Eating; Female; Fluorouracil; Head and Neck Neoplasms; Histone Deacetylase Inhibitors; Humans; Male; Middle Aged; Mitomycin; Mouthwashes; Phenylbutyrates; Pilot Projects; Radiation Injuries; Radiotherapy Dosage; Stomatitis; Taiwan; Tegafur; Uracil; Weight Loss

2012
Phase I study of cediranib in combination with cisplatin plus fluoropyrimidine (S-1 or capecitabine) in Japanese patients with previously untreated advanced gastric cancer.
    Cancer chemotherapy and pharmacology, 2012, Volume: 69, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Appetite; Area Under Curve; Asian People; Capecitabine; Cisplatin; Deoxycytidine; Drug Administration Schedule; Fatigue; Female; Fluorouracil; Humans; Hyponatremia; Japan; Male; Metabolic Clearance Rate; Middle Aged; Neutropenia; Oxonic Acid; Quinazolines; Stomach Neoplasms; Tegafur; Treatment Outcome; Tumor Burden

2012
A randomized phase II trial of S-1-oxaliplatin versus capecitabine-oxaliplatin in advanced gastric cancer.
    European journal of cancer (Oxford, England : 1990), 2012, Volume: 48, Issue:4

    Topics: Adenocarcinoma; Adult; Aged; Algorithms; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Disease Progression; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Stomach Neoplasms; Tegafur; Treatment Outcome; Young Adult

2012
High-dose radiotherapy (60 Gy) with oral UFT/folinic acid and escalating doses of oxaliplatin in patients with non-resectable locally advanced rectal cancer (LARC): a phase I trial.
    Acta oncologica (Stockholm, Sweden), 2012, Volume: 51, Issue:3

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Feasibility Studies; Female; Fluorouracil; Follow-Up Studies; Gamma Rays; Humans; Leucovorin; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Radiotherapy Dosage; Rectal Neoplasms; Survival Rate; Tegafur; Treatment Outcome; Uracil

2012
A randomized phase-II trial comparing sequential and concurrent paclitaxel with oral or parenteral fluorinated pyrimidines for advanced or metastatic gastric cancer.
    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2012, Volume: 15, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Female; Fluorouracil; Humans; Infusions, Parenteral; Male; Middle Aged; Oxonic Acid; Paclitaxel; Patient Compliance; Stomach Neoplasms; Tegafur; Treatment Outcome

2012
Dose-effect relationship in chemoradiotherapy for locally advanced rectal cancer: a randomized trial comparing two radiation doses.
    International journal of radiation oncology, biology, physics, 2012, Nov-15, Volume: 84, Issue:4

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Brachytherapy; Denmark; Dose-Response Relationship, Radiation; Female; Fluorouracil; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Staging; Prospective Studies; Quebec; Radiotherapy Dosage; Rectal Neoplasms; Remission Induction; Tegafur

2012
Usefulness of the preoperative administration of tegafur suppositories as alternative adjuvant chemotherapy for patients with resectable stage II or III colorectal cancer: a KODK4 multicenter randomized control trial.
    Oncology, 2012, Volume: 83, Issue:1

    Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Disease-Free Survival; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Preoperative Care; Preoperative Period; Suppositories; Survival Rate; Tegafur

2012
Pharmacokinetic study of S-1 in patients in whom inulin clearance was measured.
    Oncology, 2012, Volume: 83, Issue:1

    Topics: Aged; Antimetabolites, Antineoplastic; Area Under Curve; Creatinine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Glomerular Filtration Rate; Humans; Inulin; Kidney Function Tests; Male; Middle Aged; Oxonic Acid; Pyridines; Reference Values; Tegafur

2012
A randomized phase II trial to elucidate the efficacy of capecitabine plus cisplatin (XP) and S-1 plus cisplatin (SP) as a first-line treatment for advanced gastric cancer: XP ascertainment vs. SP randomized PII trial (XParTS II).
    BMC cancer, 2012, Jul-23, Volume: 12

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cisplatin; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Middle Aged; Neoplasm Staging; Oxonic Acid; Stomach Neoplasms; Tegafur; Young Adult

2012
A phase II study of docetaxel and oxaliplatin combination in recurrent gastric cancer patients after fluoropyrimidine and/or cisplatin adjuvant treatment: a Korean Cancer Study Group Protocol ST06-02.
    Cancer chemotherapy and pharmacology, 2012, Volume: 70, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Deoxycytidine; Disease-Free Survival; Docetaxel; Drug Combinations; Female; Fluorouracil; Follow-Up Studies; Humans; Korea; Male; Middle Aged; Neoplasm Recurrence, Local; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Stomach Neoplasms; Survival Rate; Taxoids; Tegafur; Treatment Outcome

2012
Phase II tailored S-1 regimen study of first-line chemotherapy in elderly patients with advanced and recurrent non-small cell lung cancer.
    Cancer chemotherapy and pharmacology, 2012, Volume: 70, Issue:6

    Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Body Surface Area; Carcinoma, Non-Small-Cell Lung; Creatinine; Disease-Free Survival; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Lung Neoplasms; Male; Oxonic Acid; Tegafur; Treatment Outcome

2012
S-1 plus oxaliplatin versus capecitabine plus oxaliplatin for first-line treatment of patients with metastatic colorectal cancer: a randomised, non-inferiority phase 3 trial.
    The Lancet. Oncology, 2012, Volume: 13, Issue:11

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Disease-Free Survival; Drug Combinations; Female; Fluorouracil; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Republic of Korea; Tegafur

2012
[A phase II prospective randomized controlled trial of weekly paclitaxel combined with S-1 or fluorouracil for advanced gastric carcinoma].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2012, Volume: 34, Issue:11

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Diarrhea; Disease-Free Survival; Drug Combinations; Female; Fluorouracil; Follow-Up Studies; Humans; Leukopenia; Male; Middle Aged; Neoplasm Staging; Oxonic Acid; Paclitaxel; Prospective Studies; Remission Induction; Stomach Neoplasms; Survival Rate; Tegafur

2012
Pharmacokinetic evaluation of novel oral fluorouracil antitumor drug S-1 in Chinese cancer patients.
    Acta pharmacologica Sinica, 2013, Volume: 34, Issue:4

    Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asian People; Cross-Over Studies; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Oxonic Acid; Pyridines; Tegafur; Therapeutic Equivalency

2013
Safety analysis of weekly paclitaxel plus S-1 versus paclitaxel plus 5-fluorouracil/calcium folinate as first-line therapy in advanced gastric cancer: a multicenter open random phase II trial.
    Journal of chemotherapy (Florence, Italy), 2013, Volume: 25, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Oxonic Acid; Paclitaxel; Stomach Neoplasms; Tegafur; Young Adult

2013
A phase I study of sorafenib in combination with S-1 plus cisplatin in patients with advanced gastric cancer.
    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2014, Volume: 17, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Niacinamide; Oxonic Acid; Patient Compliance; Phenylurea Compounds; Sorafenib; Stomach Neoplasms; Tegafur; Treatment Outcome

2014
Orally administered S-1 suppresses circulating endothelial cell counts in metastatic breast cancer patients.
    International journal of clinical oncology, 2014, Volume: 19, Issue:3

    Topics: 4-Butyrolactone; Administration, Oral; Adult; Aged; Antigens, CD34; Antimetabolites, Antineoplastic; Breast Neoplasms; Cell Count; Chemokine CCL2; Drug Combinations; Endothelial Cells; Female; Fluorouracil; Humans; Middle Aged; Neovascularization, Pathologic; Oxonic Acid; Tegafur; Thrombospondin 1; Treatment Outcome; Vascular Endothelial Growth Factor A

2014
A multicentre randomised trial comparing weekly paclitaxel + S-1 with weekly paclitaxel + 5-fluorouracil for patients with advanced gastric cancer.
    European journal of cancer (Oxford, England : 1990), 2013, Volume: 49, Issue:14

    Topics: Administration, Oral; Adolescent; Adult; Aged; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Infusions, Intravenous; Kaplan-Meier Estimate; Leucovorin; Leukopenia; Male; Middle Aged; Multivariate Analysis; Nausea; Oxonic Acid; Paclitaxel; Stomach Neoplasms; Tegafur; Treatment Outcome; Young Adult

2013
Impact of excision repair cross-complementing gene 1 (ERCC1) on the outcomes of patients with advanced gastric cancer: correlative study in Japan Clinical Oncology Group Trial JCOG9912.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2013, Volume: 24, Issue:10

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Camptothecin; Cisplatin; Dihydrouracil Dehydrogenase (NADP); DNA-Binding Proteins; Drug Combinations; Endonucleases; Female; Fluorouracil; Gene Expression; Humans; Irinotecan; Male; Oxonic Acid; Prognosis; RNA, Messenger; Stomach Neoplasms; Survival; Tegafur; Thymidylate Synthase; Vascular Endothelial Growth Factor A

2013
Combination of cisplatin/S-1 in the treatment of patients with advanced gastric or gastroesophageal adenocarcinoma: Results of noninferiority and safety analyses compared with cisplatin/5-fluorouracil in the First-Line Advanced Gastric Cancer Study.
    European journal of cancer (Oxford, England : 1990), 2013, Volume: 49, Issue:17

    Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Disease Progression; Drug Combinations; Esophageal Neoplasms; Female; Fluorouracil; Humans; Male; Middle Aged; Neoadjuvant Therapy; Oxonic Acid; Stomach Neoplasms; Tegafur; Young Adult

2013
5-Fluorouracil, mitomycin-c, and polysaccharide-k versus uracil-ftorafur and polysaccharide-K as adjuvant chemoimmunotherapy for patients with locally advanced gastric cancer with curative resection.
    Onkologie, 2013, Volume: 36, Issue:7-8

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Fluorouracil; Humans; Immunotherapy; Male; Middle Aged; Mitomycin; Prevalence; Proteoglycans; Republic of Korea; Risk Factors; Stomach Neoplasms; Survival Rate; Tegafur; Treatment Outcome; Uracil

2013
Leucovorin, fluorouracil, and oxaliplatin plus bevacizumab versus S-1 and oxaliplatin plus bevacizumab in patients with metastatic colorectal cancer (SOFT): an open-label, non-inferiority, randomised phase 3 trial.
    The Lancet. Oncology, 2013, Volume: 14, Issue:13

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Chemotherapy, Adjuvant; Colorectal Neoplasms; Disease-Free Survival; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Infusions, Intravenous; Japan; Kaplan-Meier Estimate; Leucovorin; Male; Middle Aged; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Tegafur; Treatment Outcome

2013
Comparison of short-term efficacy and safety of TIROX and DCF regimens for advanced gastric cancer.
    The Journal of international medical research, 2014, Volume: 42, Issue:3

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Docetaxel; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Irinotecan; Leukopenia; Lymphatic Metastasis; Male; Middle Aged; Neurotoxicity Syndromes; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Prospective Studies; Recurrence; Stomach Neoplasms; Taxoids; Tegafur; Treatment Outcome

2014
Neoadjuvant chemoradiation therapy using concurrent S-1 and irinotecan in rectal cancer: impact on long-term clinical outcomes and prognostic factors.
    International journal of radiation oncology, biology, physics, 2014, Jul-01, Volume: 89, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Agranulocytosis; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemoradiotherapy; Diarrhea; Disease-Free Survival; Dose Fractionation, Radiation; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Leukopenia; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Organoplatinum Compounds; Oxonic Acid; Rectal Neoplasms; Tegafur; Treatment Outcome

2014
Randomised phase III trial of adjuvant chemotherapy with oral uracil and tegafur plus leucovorin versus intravenous fluorouracil and levofolinate in patients with stage III colorectal cancer who have undergone Japanese D2/D3 lymph node dissection: final r
    European journal of cancer (Oxford, England : 1990), 2014, Volume: 50, Issue:13

    Topics: Administration, Intravenous; Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Disease-Free Survival; Female; Fluorouracil; Humans; Japan; Leucovorin; Lymph Node Excision; Male; Middle Aged; Neoplasm Staging; Tegafur; Uracil; Young Adult

2014
S-1 monotherapy as second line chemotherapy in advanced gastric cancer patients previously treated with cisplatin/infusional fluorouracil.
    International journal of clinical and experimental pathology, 2014, Volume: 7, Issue:6

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Disease-Free Survival; Drug Combinations; Female; Fluorouracil; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Oxonic Acid; Salvage Therapy; Stomach Neoplasms; Tegafur

2014
Biweekly S-1 plus paclitaxel (SPA) as second-line chemotherapy after failure from fluoropyrimidine and platinum in advanced gastric cancer: a phase II study.
    Cancer chemotherapy and pharmacology, 2014, Volume: 74, Issue:3

    Topics: Administration, Oral; Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Asian People; Disease-Free Survival; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Injections, Intravenous; Male; Middle Aged; Neutropenia; Oxonic Acid; Paclitaxel; Platinum; Stomach Neoplasms; Tegafur; Treatment Outcome

2014
A phase 3 non-inferiority study of 5-FU/l-leucovorin/irinotecan (FOLFIRI) versus irinotecan/S-1 (IRIS) as second-line chemotherapy for metastatic colorectal cancer: updated results of the FIRIS study.
    Journal of cancer research and clinical oncology, 2015, Volume: 141, Issue:1

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Drug Combinations; Female; Fluorouracil; Follow-Up Studies; Humans; Irinotecan; Leucovorin; Male; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Prognosis; Survival Rate; Tegafur

2015
S-1 monotherapy as second line chemotherapy in advanced gastric cancer patients previously treated with cisplatin/infusional fluorouracil.
    International journal of clinical and experimental pathology, 2014, Volume: 7, Issue:7

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Cisplatin; Disease-Free Survival; Drug Combinations; Female; Fluorouracil; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Oxonic Acid; Salvage Therapy; Stomach Neoplasms; Tegafur

2014
A phase II study of S-1 chemotherapy with concurrent thoracic radiotherapy in elderly patients with locally advanced non-small-cell lung cancer: the Okayama Lung Cancer Study Group Trial 0801.
    European journal of cancer (Oxford, England : 1990), 2014, Volume: 50, Issue:16

    Topics: Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Disease Progression; Disease-Free Survival; Drug Combinations; Female; Fluorouracil; Humans; Lung Neoplasms; Male; Neoplasm Metastasis; Oxonic Acid; Recurrence; Tegafur; Tomography, X-Ray Computed; Treatment Outcome

2014
HPV Status Determines the Efficacy of Adjuvant Chemotherapy With S-1, an Oral Fluorouracil Prodrug, in Oropharyngeal Cancer.
    The Annals of otology, rhinology, and laryngology, 2015, Volume: 124, Issue:5

    Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Drug Combinations; Drug Therapy, Combination; Female; Fluorouracil; Humans; Immunohistochemistry; Male; Oropharyngeal Neoplasms; Oxonic Acid; Papillomaviridae; Prodrugs; Retrospective Studies; Tegafur; Treatment Outcome

2015
S-1 plus oxaliplatin versus capecitabine plus oxaliplatin for the first-line treatment of patients with metastatic colorectal cancer: updated results from a phase 3 trial.
    BMC cancer, 2014, Nov-26, Volume: 14

    Topics: Adult; Aged; Antineoplastic Agents; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Survival Analysis; Tegafur; Treatment Outcome

2014
Feasibility study of supportive care using lafutidine, a histamine H2 receptor antagonist, to prevent gastrointestinal toxicity during chemotherapy for gastric cancer.
    Anticancer research, 2014, Volume: 34, Issue:12

    Topics: Acetamides; Adenocarcinoma; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Diarrhea; Drug Combinations; Female; Fluorouracil; Gastrectomy; Gastrointestinal Tract; Histamine H2 Antagonists; Humans; Lymph Node Excision; Male; Middle Aged; Nausea; Oxonic Acid; Piperidines; Prospective Studies; Pyridines; Quality of Life; Stomach Neoplasms; Tegafur

2014
Favorable effect of the combination of vinorelbine and dihydropyrimidine dehydrogenase‑inhibitory fluoropyrimidine in EGFR‑mutated lung adenocarcinoma: retrospective and in vitro studies.
    International journal of oncology, 2015, Volume: 46, Issue:3

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; ErbB Receptors; Female; Fluorouracil; Gefitinib; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Middle Aged; Mutation; Oxonic Acid; Quinazolines; Retrospective Studies; Tegafur; Treatment Outcome; Vinblastine; Vinorelbine

2015
A randomized phase II study of combination therapy with S-1, oral leucovorin, and oxaliplatin (SOL) and mFOLFOX6 in patients with previously untreated metastatic colorectal cancer.
    Cancer chemotherapy and pharmacology, 2015, Volume: 75, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease-Free Survival; Drug Combinations; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Survival Rate; Tegafur; Treatment Outcome

2015
Clinical Benefit and Health-Related Quality of Life Assessment in Patients Treated with Cisplatin/S-1 Versus Cisplatin/5-FU: Secondary End Point Results From the First-Line Advanced Gastric Cancer Study (FLAGS).
    Journal of gastrointestinal cancer, 2015, Volume: 46, Issue:2

    Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Combinations; Esophageal Neoplasms; Female; Fluorouracil; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Staging; Oxonic Acid; Prognosis; Quality of Life; Stomach Neoplasms; Survival Rate; Tegafur; Young Adult

2015
Randomized study of orally administered fluorinated pyrimidines (capecitabine versus S-1) in women with metastatic or recurrent breast cancer: Japan Breast Cancer Research Network 05 Trial.
    Cancer chemotherapy and pharmacology, 2015, Volume: 75, Issue:6

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Breast Neoplasms; Capecitabine; Deoxycytidine; Disease-Free Survival; Drug Combinations; Female; Fluorouracil; Humans; Japan; Middle Aged; Neoplasm Recurrence, Local; Oxonic Acid; Pyrimidines; Tegafur

2015
[Immediate results of combined therapy for local recurrences of rectal cancer].
    Voprosy onkologii, 2015, Volume: 61, Issue:1

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemotherapy, Adjuvant; Deoxycytidine; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Palliative Care; Radiation Injuries; Rectal Neoplasms; Severity of Illness Index; Tegafur; Treatment Outcome

2015
Phase I study of postoperative radiotherapy concurrent with S-1 in patients with gastric cancer.
    Medical oncology (Northwood, London, England), 2015, Volume: 32, Issue:7

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy, Adjuvant; Combined Modality Therapy; Drug Combinations; Female; Fluorouracil; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Postoperative Care; Stomach Neoplasms; Tegafur

2015
Randomised study of tegafur-uracil plus leucovorin versus capecitabine as first-line therapy in elderly patients with advanced colorectal cancer--TLC study.
    Journal of geriatric oncology, 2015, Volume: 6, Issue:4

    Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Disease-Free Survival; Drug Administration Schedule; Female; Fluorouracil; Follow-Up Studies; Frail Elderly; Humans; Leucovorin; Male; Prospective Studies; Tegafur; Treatment Outcome; Vitamin B Complex

2015
S-1 and irinotecan with or without bevacizumab versus 5-fluorouracil and leucovorin plus oxaliplatin with or without bevacizumab in metastatic colorectal cancer: a pooled analysis of four phase II studies.
    Cancer chemotherapy and pharmacology, 2015, Volume: 76, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colorectal Neoplasms; Drug Combinations; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Tegafur; Treatment Outcome

2015
Study protocol of the TRICOLORE trial: a randomized phase III study of oxaliplatin-based chemotherapy versus combination chemotherapy with S-1, irinotecan, and bevacizumab as first-line therapy for metastatic colorectal cancer.
    BMC cancer, 2015, Sep-09, Volume: 15

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Cost-Benefit Analysis; Disease-Free Survival; Drug Combinations; Female; Fluorouracil; Health Care Costs; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Quality of Life; Tegafur; Young Adult

2015
Exploratory phase II trial in a multicenter setting to evaluate the clinical value of a chemosensitivity test in patients with gastric cancer (JACCRO-GC 04, Kubota memorial trial).
    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2016, Volume: 19, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; Drug Combinations; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Fluorouracil; Gastrectomy; Gene Expression Regulation, Neoplastic; Humans; Male; Middle Aged; Oxonic Acid; Stomach Neoplasms; Tegafur; Treatment Outcome

2016
Randomized phase II study of second-line chemotherapy with the best available 5-fluorouracil regimen versus weekly administration of paclitaxel in far advanced gastric cancer with severe peritoneal metastases refractory to 5-fluorouracil-containing regime
    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2016, Volume: 19, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Drug Combinations; Female; Fluorouracil; Follow-Up Studies; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Oxonic Acid; Paclitaxel; Peritoneal Neoplasms; Prognosis; Stomach Neoplasms; Survival Rate; Tegafur

2016
S-1 plus cisplatin versus fluorouracil plus cisplatin in advanced gastric or gastro-esophageal junction adenocarcinoma patients: a pilot study.
    Oncotarget, 2015, Oct-27, Volume: 6, Issue:33

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Disease-Free Survival; Drug Combinations; Esophagogastric Junction; Female; Fluorouracil; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Oxonic Acid; Pilot Projects; Stomach Neoplasms; Tegafur

2015
A Randomized Phase 2 Study of Neoadjuvant Chemoradiaton Therapy With 5-Fluorouracil/Leucovorin or Irinotecan/S-1 in Patients With Locally Advanced Rectal Cancer.
    International journal of radiation oncology, biology, physics, 2015, Dec-01, Volume: 93, Issue:5

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemoradiotherapy, Adjuvant; Chi-Square Distribution; Confidence Intervals; Disease-Free Survival; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Induction Chemotherapy; Irinotecan; Leucovorin; Male; Middle Aged; Neoadjuvant Therapy; Oxonic Acid; Rectal Neoplasms; Tegafur

2015
Randomized phase II trial of TEGAFIRI (tegafur/uracil, oral leucovorin, irinotecan) compared with FOLFIRI (folinic acid, 5-fluorouracil, irinotecan) in patients with unresectable/recurrent colorectal cancer.
    International journal of cancer, 2016, Aug-15, Volume: 139, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Disease Progression; Female; Fluorouracil; Humans; Kaplan-Meier Estimate; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Odds Ratio; Proportional Hazards Models; Recurrence; Tegafur; Treatment Failure; Treatment Outcome

2016
Tumor 5-FU-related mRNA Expression and Efficacy of Oral Fluoropyrimidines in Adjuvant Chemotherapy of Colorectal Cancer.
    Anticancer research, 2016, Volume: 36, Issue:10

    Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Carcinoma; Chemotherapy, Adjuvant; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Orotate Phosphoribosyltransferase; Oxonic Acid; RNA, Messenger; Tegafur; Tetrahydrofolate Dehydrogenase; Thymidine Phosphorylase; Thymidylate Synthase; Treatment Outcome

2016
Phase II trial of S-1 plus leucovorin in patients with advanced gastric cancer and clinical prediction by S-1 pharmacogenetic pathway.
    Cancer chemotherapy and pharmacology, 2017, Volume: 79, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cytochrome P-450 CYP2A6; Disease-Free Survival; Drug Combinations; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Orotate Phosphoribosyltransferase; Oxonic Acid; Pharmacogenomic Testing; Stomach Neoplasms; Tegafur

2017
Maintenance treatment of Uracil and Tegafur (UFT) in responders following first-line fluorouracil-based chemotherapy in metastatic gastric cancer: a randomized phase II study.
    Oncotarget, 2017, Jun-06, Volume: 8, Issue:23

    Topics: Adult; Aged; Disease-Free Survival; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Metastasis; Stomach Neoplasms; Tegafur; Uracil; Young Adult

2017
Comparative study of cisplatin-based definitive concurrent chemoradiotherapy with S-1 versus paclitaxel for unresectable locally advanced esophageal squamous cell carcinoma.
    Oncotarget, 2017, Jun-06, Volume: 8, Issue:23

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiotherapy; Cisplatin; Disease-Free Survival; Drug Combinations; Esophageal Neoplasms; Female; Fluorouracil; Humans; Male; Middle Aged; Nausea; Neutropenia; Oxonic Acid; Paclitaxel; Remission Induction; Retrospective Studies; Tegafur; Vomiting

2017
Randomized Controlled Trial of Adjuvant Chemotherapy with Fluoropyrimidines
    Anticancer research, 2017, Volume: 37, Issue:6

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Staging; Stomach Neoplasms; Survival Analysis; Tegafur; Uracil

2017
A phase III trial comparing oral S-1/cisplatin and intravenous 5-fluorouracil/cisplatin in patients with untreated diffuse gastric cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2017, Sep-01, Volume: 28, Issue:9

    Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Combinations; Esophagogastric Junction; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasm Metastasis; Oxonic Acid; Stomach Neoplasms; Survival Analysis; Tegafur

2017
Patient-Reported Outcome Results from the Open-Label Randomized Phase III SELECT BC Trial Evaluating First-Line S-1 Therapy for Metastatic Breast Cancer.
    Oncology, 2018, Volume: 94, Issue:2

    Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Bridged-Ring Compounds; Drug Combinations; Female; Fluorouracil; Health Status; Humans; Middle Aged; Neoplasm Recurrence, Local; Oxonic Acid; Patient Reported Outcome Measures; Quality of Life; Surveys and Questionnaires; Taxoids; Tegafur

2018
S-1 and irinotecan plus bevacizumab versus mFOLFOX6 or CapeOX plus bevacizumab as first-line treatment in patients with metastatic colorectal cancer (TRICOLORE): a randomized, open-label, phase III, noninferiority trial.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2018, 03-01, Volume: 29, Issue:3

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Capecitabine; Colorectal Neoplasms; Disease-Free Survival; Drug Combinations; Female; Fluorouracil; Humans; Irinotecan; Kaplan-Meier Estimate; Leucovorin; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Progression-Free Survival; Tegafur; Young Adult

2018
Effects of ω-3 Fatty Acid Supplementation in Patients with Bile Duct or Pancreatic Cancer Undergoing Chemotherapy.
    Anticancer research, 2018, Volume: 38, Issue:4

    Topics: Aged; Aged, 80 and over; Albumins; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Cachexia; Camptothecin; Combined Modality Therapy; Deoxycytidine; Dietary Supplements; Drug Combinations; Fatty Acids, Omega-3; Female; Fluorouracil; Gemcitabine; Humans; Leucovorin; Male; Middle Aged; Nutritional Support; Organoplatinum Compounds; Oxonic Acid; Paclitaxel; Pancreatic Neoplasms; Pyridines; Tegafur

2018
A randomized phase III study of hepatic arterial infusion chemotherapy with 5-fluorouracil and subsequent systemic chemotherapy versus systemic chemotherapy alone for colorectal cancer patients with curatively resected liver metastases (Japanese Foundatio
    Journal of cancer research and therapeutics, 2018, Volume: 14, Issue:Supplement

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease-Free Survival; Female; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Leucovorin; Liver; Liver Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Tegafur

2018
A multicenter phase III study comparing Simultaneous Integrated Boost (SIB) radiotherapy concurrent and consolidated with S-1 versus SIB alone in elderly patients with esophageal and esophagogastric cancer - the 3JECROG P-01 study protocol.
    BMC cancer, 2019, Apr-29, Volume: 19, Issue:1

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiotherapy; Drug Combinations; Esophageal Neoplasms; Esophagogastric Junction; Female; Fluorouracil; Humans; Male; Neoplasm Staging; Outcome Assessment, Health Care; Oxonic Acid; Prospective Studies; Radiotherapy, Intensity-Modulated; Stomach Neoplasms; Tegafur

2019
Pharmacokinetic and bioequivalence study between two formulations of S-1 in Korean gastric cancer patients.
    Drug design, development and therapy, 2019, Volume: 13

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Chromatography, Liquid; Cross-Over Studies; Drug Compounding; Fluorouracil; Humans; Oxonic Acid; Pyridines; Republic of Korea; Stomach Neoplasms; Tandem Mass Spectrometry; Tegafur; Therapeutic Equivalency

2019
Phase II study of S-1-based sequential combination chemotherapy including oxaliplatin plus bevacizumab and irinotecan with or without cetuximab for metastatic colorectal cancer: the SOBIC trial.
    International journal of clinical oncology, 2020, Volume: 25, Issue:7

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Cetuximab; Colorectal Neoplasms; Drug Combinations; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Oxaliplatin; Oxonic Acid; Progression-Free Survival; Tegafur; Treatment Outcome

2020
Endoscopic radiofrequency ablation plus a novel oral 5-fluorouracil compound versus radiofrequency ablation alone for unresectable extrahepatic cholangiocarcinoma.
    Gastrointestinal endoscopy, 2020, Volume: 92, Issue:6

    Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Bile Duct Neoplasms; Bile Ducts, Extrahepatic; Cholangiocarcinoma; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Oxonic Acid; Prospective Studies; Radiofrequency Ablation; Tegafur; Treatment Outcome

2020
Oral S-1 with 24-h Infusion of Irinotecan plus Bevacizumab versus FOLFIRI plus Bevacizumab as First-Line Chemotherapy for Metastatic Colorectal Cancer: An Open-Label Randomized Phase II Trial.
    Oncology, 2020, Volume: 98, Issue:9

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colorectal Neoplasms; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Oxonic Acid; Progression-Free Survival; Survival Rate; Tegafur; Young Adult

2020
Phase I Study of Alternate-Day Administration of S-1, Oral Leucovorin, and Bevacizumab for Refractory Metastatic Colorectal Cancer.
    The oncologist, 2020, Volume: 25, Issue:11

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Colorectal Neoplasms; Drug Combinations; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Oxonic Acid; Tegafur; Treatment Outcome

2020
An Open-Label Single-Arm Phase II Study of Treatment with Neoadjuvant S-1 Plus Cisplatin for Clinical Stage III Squamous Cell Carcinoma of the Esophagus.
    The oncologist, 2020, Volume: 25, Issue:11

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Drug Combinations; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagectomy; Female; Fluorouracil; Humans; Japan; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Oxonic Acid; Tegafur; Treatment Outcome

2020
A Chinese Retrospective Multicenter Study of First-Line Chemotherapy for Advanced Pancreatic Cancer.
    Medical science monitor : international medical journal of experimental and clinical research, 2020, Oct-26, Volume: 26

    Topics: Adult; Aged; Albumins; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; China; Deoxycytidine; Drug Combinations; Female; Fluorouracil; Gemcitabine; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Oxaliplatin; Oxonic Acid; Paclitaxel; Pancreatic Neoplasms; Progression-Free Survival; Retrospective Studies; Tegafur

2020
Prospective evaluation and refinement of an S-1 dosage formula based on renal function for clinical application.
    Cancer science, 2021, Volume: 112, Issue:2

    Topics: Aged; Antimetabolites, Antineoplastic; Dose-Response Relationship, Drug; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Nomograms; Oxonic Acid; Renal Insufficiency; Tegafur

2021
Randomized phase II study comparing the efficacy and safety of SOX versus mFOLFOX6 as neoadjuvant chemotherapy without radiotherapy for locally advanced rectal cancer (KSCC1301).
    BMC cancer, 2021, Jan-05, Volume: 21, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Drug Combinations; Female; Fluorouracil; Follow-Up Studies; Humans; Leucovorin; Male; Middle Aged; Neoadjuvant Therapy; Oxaliplatin; Oxonic Acid; Prognosis; Rectal Neoplasms; Survival Rate; Tegafur

2021
Combination therapy of bevacizumab with either S-1 and irinotecan or mFOLFOX6/CapeOX as first-line treatment of metastatic colorectal cancer (TRICOLORE): Exploratory analysis of RAS status and primary tumour location in a randomised, open-label, phase III
    European journal of cancer (Oxford, England : 1990), 2021, Volume: 154

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Colorectal Neoplasms; Drug Combinations; Female; Fluorouracil; Genes, ras; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Mutation; Neoplasm Metastasis; Organoplatinum Compounds; Oxonic Acid; Proto-Oncogene Proteins B-raf; Quality of Life; Tegafur

2021
Preoperative chemoradiotherapy using tegafur/uracil, oral leucovorin, and irinotecan (TEGAFIRI) followed by oxaliplatin-based chemotherapy as total neoadjuvant therapy for locally advanced rectal cancer: the study protocol for a phase II trial.
    BMC cancer, 2023, May-17, Volume: 23, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Clinical Trials, Phase II as Topic; Fluorouracil; Humans; Irinotecan; Leucovorin; Neoadjuvant Therapy; Neoplasm Staging; Oxaliplatin; Rectal Neoplasms; Tegafur; Treatment Outcome

2023

Other Studies

962 other study(ies) available for fluorouracil and tegafur

ArticleYear
Studies of antitumor agents. 1. Resolution of racemic 1-(tetrahydro-2-furanyl)-k-fluorouracil into the R and S isomers and examination of the biological activities of the isomers.
    Journal of medicinal chemistry, 1977, Volume: 20, Issue:12

    Topics: Animals; Bacteria; Fluorouracil; In Vitro Techniques; Male; Mice; Microsomes, Liver; Neoplasms, Experimental; Rats; Stereoisomerism; Structure-Activity Relationship; Tegafur

1977
Studies on antitumor agents, 2. Syntheses and antitumor activities of 1-(tetrahydro-2-furanyl)-5-fluorouracil and 1,3-bis(tetrahydro-2-furanyl)-5-fluorouracil.
    Journal of medicinal chemistry, 1978, Volume: 21, Issue:8

    Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Fluorouracil; Lethal Dose 50; Mice; Neoplasms, Experimental; Rats; Sarcoma 180; Sarcoma, Yoshida; Tegafur

1978
Synthesis and biological activities of ftorafur metabolites. 3'- and 4'-hydroxyftorafur.
    Journal of medicinal chemistry, 1979, Volume: 22, Issue:9

    Topics: Animals; Antineoplastic Agents; Cell Division; Fluorouracil; HeLa Cells; Humans; Hydroxylation; Leukemia L1210; Stereoisomerism; Tegafur

1979
Synthesis and antitumor activity of a series of ftorafur analogues: the effect of varying electronegativity at the 1'-position.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:2

    Topics: Animals; Antineoplastic Agents; Cells, Cultured; Female; Fluorouracil; Leukemia L1210; Leukemia P388; Mice; Tegafur

1985
(o- and p-Nitrobenzyloxycarbonyl)-5-fluorouracil derivatives as potential conjugated bioreductive alkylating agents.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:1

    Topics: Animals; Cells, Cultured; Chemical Phenomena; Chemistry; Fluorouracil; Leukemia P388; Mice; Neoplasms, Experimental; Oxygen; Sarcoma 180; Structure-Activity Relationship

1986
Fluorinated pyrimidine nucleosides. 4. Synthesis and antitumor testing of a series of 2',5'-dideoxy- and 2',3',5'-trideoxynucleosides of 5-fluorouracil.
    Journal of medicinal chemistry, 1980, Volume: 23, Issue:8

    Topics: Animals; Antineoplastic Agents; Deoxyuridine; Floxuridine; Fluorouracil; Mice; Sarcoma 180; Tegafur

1980
Synthesis and biological evaluation of novel pyrimidine nucleoside analogues of 1,4-oxathiane, 1,4-dithiane, and 1,4-dioxane.
    Journal of medicinal chemistry, 1982, Volume: 25, Issue:5

    Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chemical Phenomena; Chemistry; Fluorouracil; Heterocyclic Compounds; Humans; Mice; Neoplasms, Experimental; Pyrimidine Nucleosides

1982
Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability.
    Journal of medicinal chemistry, 1980, Volume: 23, Issue:6

    Topics: Animals; Blood-Brain Barrier; Brain; Capillary Permeability; Male; Models, Biological; Molecular Weight; Rats; Rats, Inbred F344; Solubility; Structure-Activity Relationship

1980
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
    Journal of medicinal chemistry, 1980, Volume: 23, Issue:12

    Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Female; Fluorouracil; Lethal Dose 50; Leukemia P388; Mice; Neoplasms, Experimental

1980
Thermodynamic aspects of hydrophobicity and the blood-brain barrier permeability studied with a gel filtration chromatography.
    Journal of medicinal chemistry, 1996, Jun-21, Volume: 39, Issue:13

    Topics: Blood-Brain Barrier; Chromatography, Gel; Hydrogen Bonding; Micelles; Permeability; Solubility; Thermodynamics

1996
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016
Fluoropyrimidin-2,4-dihydroxy-5-isopropylbenzamides as antitumor agents against CRC and NSCLC cancer cells.
    European journal of medicinal chemistry, 2020, Oct-01, Volume: 203

    Topics: Antineoplastic Agents; Apoptosis; Benzamides; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Line, Tumor; Colorectal Neoplasms; Cytoprotection; Enzyme Activation; ErbB Receptors; Humans; Inhibitory Concentration 50; Lung Neoplasms; Mutation; Proteolysis; Proto-Oncogene Proteins c-akt

2020
A new sulfated triterpene glycoside from the sea cucumber Colochirus quadrangularis, and evaluation of its antifungal, antitumor and immunomodulatory activities.
    Bioorganic & medicinal chemistry, 2021, 07-01, Volume: 41

    Topics: Animals; Antifungal Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Glycosides; Humans; Immunomodulation; Mice; Mice, Nude; Molecular Structure; Neoplasms, Experimental; Saponins; Sea Cucumbers; Triterpenes

2021
[Participation of non-specific rat liver microsome oxidases in destruction of Nl-furanidylpyrimidines].
    Biulleten' eksperimental'noi biologii i meditsiny, 1977, Volume: 83, Issue:2

    Topics: Animals; Biotransformation; Fluorouracil; Male; Microsomes, Liver; NADP; Proadifen; Rats; Tegafur

1977
Comparative studies on the metabolism of 2-(tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil.
    Gan, 1977, Volume: 68, Issue:5

    Topics: Alanine; Animals; DNA, Neoplasm; Fluorouracil; In Vitro Techniques; Male; Mice; Microsomes, Liver; NADP; Neoplasms, Experimental; Nucleic Acid Precursors; Rats; Tegafur; Tissue Distribution

1977
[Effectiveness of ftorafur and hexamethylmelamine in advanced breast cancer].
    Voprosy onkologii, 1978, Volume: 24, Issue:8

    Topics: Adult; Altretamine; Breast Neoplasms; Drug Therapy, Combination; Female; Fluorouracil; Humans; Leukopenia; Middle Aged; Neoplasm Metastasis; Tegafur; Triazines

1978
Immunobiology and therapeutic manipulation of heterotransplanted Nb rat prostatic adenocarcinoma. Chemotherapy of autonomous tumor, 102 Pr, heterotransplanted into congenitally athymic (nude) mice and syngeneic Nb rats.
    Cancer chemotherapy and pharmacology, 1979, Volume: 3, Issue:3

    Topics: Adenocarcinoma; Animals; Fluorouracil; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Prostatic Neoplasms; Rats; Rats, Inbred Strains; Tegafur; Time Factors; Transplantation, Heterologous

1979
Ftorafur: a self-limiting source of 5-fluorouracil?
    Cancer chemotherapy and pharmacology, 1979, Volume: 3, Issue:1

    Topics: Animals; Biotransformation; Fluorouracil; Hematopoietic Stem Cells; Lethal Dose 50; Leukemia L1210; Mice; Osteosarcoma; Sarcoma, Experimental; Tegafur

1979
[Experimental study relating to the anti-cancer effect of FT-207 suppository (author's transl)].
    Nihon Gan Chiryo Gakkai shi, 1979, Oct-20, Volume: 14, Issue:6

    Topics: Animals; Carcinoma, Squamous Cell; Female; Fluorouracil; Methylcholanthrene; Mice; Neoplasms, Experimental; Skin Neoplasms; Suppositories; Tegafur

1979
[Long-term oral administration of anticancer drug (author's transl)].
    Nihon Gan Chiryo Gakkai shi, 1979, Dec-20, Volume: 14, Issue:7

    Topics: Administration, Oral; Ambulatory Care; Antineoplastic Agents; Fluorouracil; Humans; Immunoglobulins; Middle Aged; Neoplasms; Tegafur; Time Factors

1979
Studies on tetrahydrofuranyl-5-fluorouracils. 2. NMR studies of 1-(tetrahydro-2-furanyl)-, 3-(tetrahydro-2-furanyl)-, and 1,3-bis(tetrahydro-2-furanyl)-5-fluorouracils.
    Nucleic acids symposium series, 1979, Issue:6

    Topics: Fluorouracil; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Structure-Activity Relationship; Tegafur

1979
[Mechanism of the chromosome damaging effect of ftorafur].
    Genetika, 1977, Volume: 13, Issue:3

    Topics: Animals; Cell Line; Chromosome Aberrations; Chromosomes; Cricetinae; Floxuridine; Fluorouracil; Mitosis; Mutagens; Tegafur; Thymidine

1977
Futraful therapy on liver cancer.
    Clinical oncology, 1977, Volume: 3, Issue:1

    Topics: Administration, Oral; Adult; Aged; Alkaline Phosphatase; Carcinoma, Hepatocellular; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluorouracil; Humans; L-Lactate Dehydrogenase; Liver Neoplasms; Male; Middle Aged; Mitomycins; Neoplasm Metastasis; Remission, Spontaneous; Suppositories; Tegafur; Time Factors

1977
[Characteristic pharmacodynamic in 1-(2-tetrahydrofuryl)-5-fluorouracil metabolism and its clinical efficacy in patients with primary hepatoma (author's transl)].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1978, Volume: 75, Issue:12

    Topics: Adult; Aged; Carcinoma, Hepatocellular; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Tegafur

1978
Decreased disappearance rate of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) from the blood and its unresponsiveness to tocophreyl nicotinate and indomethacin in patients with primary hepatocellular carcinoma.
    Acta medica Okayama, 1979, Volume: 33, Issue:5

    Topics: Carcinoma, Hepatocellular; Fluorouracil; Humans; Indomethacin; Kinetics; Liver Cirrhosis; Liver Neoplasms; Microsomes, Liver; Nicotinic Acids; Tegafur; Vitamin E

1979
High-pressure liquid chromatographic analysis of ftorafur and its metabolites in biological fluids.
    Journal of chromatography, 1977, Apr-01, Volume: 134, Issue:1

    Topics: Chromatography, High Pressure Liquid; Fluorouracil; Humans; Kinetics; Spectrophotometry, Ultraviolet; Tegafur

1977
[Chemotherapy of cancer of the proximal region of the stomach].
    Klinicheskaia meditsina, 1977, Volume: 55, Issue:2

    Topics: Antineoplastic Agents; Drug Therapy, Combination; Fluorouracil; Humans; Male; Middle Aged; Stomach Neoplasms; Tegafur

1977
[Therapeutic effect of ftorafur].
    Veterinariia, 1977, Issue:1

    Topics: Adenocarcinoma; Animals; Cat Diseases; Cats; Dog Diseases; Dogs; Female; Fluorouracil; Mammary Glands, Animal; Neoplasms; Rectal Neoplasms; Tegafur

1977
[Action of ftorafur and 5-fluorouracil on the chromosomes of normal and tumorous cells in vivo].
    Voprosy onkologii, 1977, Volume: 23, Issue:2

    Topics: Animals; Bone Marrow; Bone Marrow Cells; Chromosomes; Cricetinae; Dose-Response Relationship, Drug; Fluorouracil; Humans; Intestinal Neoplasms; Male; Mice; Mice, Inbred Strains; Mitosis; Neoplasm Transplantation; Tegafur; Thymectomy; Time Factors

1977
Comparison of the actions of 5-fluorouracil and ftorafur in Escherichia coli.
    Antimicrobial agents and chemotherapy, 1977, Volume: 11, Issue:3

    Topics: Drug Resistance, Microbial; Escherichia coli; Fluorouracil; Tegafur; Time Factors; Uracil

1977
[Analytical study of ftorafur-N 1-(2'-furanidil)-5-fluorouratil].
    Ceskoslovenska farmacie, 1977, Volume: 26, Issue:3

    Topics: Chromatography, Thin Layer; Fluorouracil; Indicators and Reagents; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Tegafur; Temperature

1977
[Pharmacokinetics of ftorafur-2-14C in rats with Walker carcinosarcoma].
    Biulleten' eksperimental'noi biologii i meditsiny, 1977, Volume: 83, Issue:6

    Topics: Animals; Carcinoma 256, Walker; Fluorouracil; Male; Mice; Tegafur

1977
[Regression of a recurrent malignant glioma by combined chemoradiotherapy utilizing carboquone, FT-207 and telecobalt--report of a case (author's transl)].
    No shinkei geka. Neurological surgery, 1977, Volume: 5, Issue:8

    Topics: Azirines; Brain Neoplasms; Carbazilquinone; Cobalt Radioisotopes; Drug Therapy, Combination; Fluorouracil; Frontal Lobe; Glioma; Humans; Infusions, Parenteral; Male; Middle Aged; Neoplasm Recurrence, Local; Quinones; Radioisotope Teletherapy; Tegafur

1977
[Ftorafur concentration in the blood and urine of oncological patients].
    Voprosy onkologii, 1977, Volume: 23, Issue:8

    Topics: Biopharmaceutics; Biotransformation; Breast Neoplasms; Dose-Response Relationship, Drug; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Kinetics; Neoplasm Metastasis; Neoplasms; Tegafur; Time Factors; Tissue Distribution

1977
[A combined immuno-chemotherapy with futraful and picibanil for advanced cancer (author's transl)].
    Nihon Gan Chiryo Gakkai shi, 1977, Sep-20, Volume: 12, Issue:3

    Topics: Aged; Biological Products; Drug Therapy, Combination; Female; Fluorouracil; Humans; Intestinal Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasms; Pancreatic Neoplasms; Picibanil; Stomach Neoplasms; Tegafur

1977
Chemoimmunotherapy of metastatic large bowel cancer: nonspecific stimulation with BCG and levamisole.
    Cancer, 1977, Volume: 40, Issue:5 Suppl

    Topics: BCG Vaccine; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Humans; Levamisole; Lomustine; Methotrexate; Neoplasm Metastasis; Rectal Neoplasms; Tegafur

1977
Intermittent high single-dose ftorafur: phase I clinical trial with a pharmacologic-toxicity correlation.
    Cancer treatment reports, 1977, Volume: 61, Issue:8

    Topics: Adult; Aged; Evaluation Studies as Topic; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Tegafur

1977
Phase II clinical trial of ftorafur in 5-fluorouracil-refractory colorectal cancer.
    Cancer treatment reports, 1977, Volume: 61, Issue:8

    Topics: Adult; Aged; Colonic Neoplasms; Drug Evaluation; Female; Fluorouracil; Humans; Male; Middle Aged; Rectal Neoplasms; Tegafur

1977
Iv methyl-CCNU and ftorafur with or without methanol-extracted residue of BCG for metastatic adenocarcinoma of the colon.
    Cancer treatment reports, 1977, Volume: 61, Issue:8

    Topics: Adenocarcinoma; BCG Vaccine; Colonic Neoplasms; Fluorouracil; Humans; Injections, Intravenous; Leukopenia; Middle Aged; Neoplasm Metastasis; Nitrosourea Compounds; Semustine; Tegafur; Thrombocytopenia

1977
GLC determination for ftorafur in biological fluids.
    Journal of pharmaceutical sciences, 1977, Volume: 66, Issue:10

    Topics: Chromatography, Gas; Drug Stability; Fluorouracil; Humans; Methods; Tegafur; Time Factors

1977
Hydroxylated metabolies of R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil (Ftorafur) in rats and rabbits.
    Cancer research, 1978, Volume: 38, Issue:1

    Topics: Animals; Chemical Phenomena; Chemistry; Female; Fluorouracil; Hydroxylation; Male; Rabbits; Rats; Stereoisomerism; Tegafur

1978
[Use of fluorafur in the therapy of various chronic dermatoses].
    Vestnik dermatologii i venerologii, 1977, Issue:11

    Topics: Adult; Aged; Chronic Disease; Fluorouracil; Humans; Male; Middle Aged; Neurodermatitis; Psoriasis; Skin Diseases; Tegafur

1977
[Chemoimmunotherapy with BCG and FT 207 (author's transl)].
    Nihon geka hokan. Archiv fur japanische Chirurgie, 1977, Nov-01, Volume: 46, Issue:6

    Topics: Adult; Aged; BCG Vaccine; Erythrocyte Count; Female; Fluorouracil; Humans; Lymphocytes; Male; Middle Aged; Neoplasms; Tegafur

1977
[Action of ftorafur on the chromosomes of normal and tumorous cells of the Djzungarian hamster in vitro].
    Genetika, 1978, Volume: 14, Issue:3

    Topics: Animals; Cell Line; Cells, Cultured; Chromatids; Chromosomes; Cricetinae; Fluorouracil; In Vitro Techniques; Metaphase; Neoplasms, Experimental; Tegafur

1978
[Use of ftorafur in disseminated breast cancer].
    Klinicheskaia meditsina, 1978, Volume: 56, Issue:5

    Topics: Administration, Oral; Adult; Aged; Breast Neoplasms; Capsules; Female; Fluorouracil; Humans; Middle Aged; Neoplasm Metastasis; Tegafur

1978
[A clinicopathological study on preoperative anticancer chemotherapy for gastric cancer (author's transl)].
    Nihon geka hokan. Archiv fur japanische Chirurgie, 1978, May-01, Volume: 47, Issue:3

    Topics: Adult; Aged; Antineoplastic Agents; Cytarabine; Drug Synergism; Drug Therapy, Combination; Female; Fluorouracil; Humans; Lymphatic Metastasis; Male; Middle Aged; Mitomycins; Preoperative Care; Stomach Neoplasms; Tegafur

1978
Chemoimmunotherapy with BCG and FT 207 (II).
    Nihon geka hokan. Archiv fur japanische Chirurgie, 1978, May-01, Volume: 47, Issue:3

    Topics: BCG Vaccine; Colonic Neoplasms; Fluorouracil; Humans; Rectal Neoplasms; Tegafur

1978
Disposition and metabolism of 1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) in humans.
    Cancer research, 1978, Volume: 38, Issue:11 Pt 1

    Topics: Animals; Female; Fluorouracil; Half-Life; Humans; In Vitro Techniques; Male; Mice; Microsomes, Liver; Rats; Tegafur; Tissue Distribution

1978
[Experimental study on the effects of local administration of anticancer drug to the regional lymph nodes (author's transl)].
    Nihon Gan Chiryo Gakkai shi, 1978, Aug-20, Volume: 13, Issue:4

    Topics: Administration, Topical; Animals; Antineoplastic Agents; Dogs; Fluorouracil; Lymph Nodes; Neoplasms, Experimental; Tegafur; Tissue Distribution

1978
Photosensitivity due to a fluorouracil derivative.
    Archives of dermatology, 1978, Volume: 114, Issue:10

    Topics: Fluorouracil; Humans; Lichen Planus; Male; Middle Aged; Photosensitivity Disorders; Tegafur; Ultraviolet Rays

1978
Metabolism and disposition of Baker's antifolate (NSC-139105), ftorafur (NSC-148958), and dichloroallyl lawsone (NSC-126771) in man.
    Drug metabolism reviews, 1978, Volume: 8, Issue:1

    Topics: Antineoplastic Agents; Diffusion; Fluorouracil; Folic Acid Antagonists; Humans; Kinetics; Liver Diseases; Naphthoquinones; Tegafur; Time Factors; Triazines

1978
[Chromosome aberrations and sister chromatid exchanges following exposure of cultured Chinese hamster cells to ftorafur and 5-fluorouracil].
    Genetika, 1978, Volume: 14, Issue:10

    Topics: Cell Line; Chromatids; Chromosome Aberrations; Chromosomes; Fluorouracil; Mutagens; Tegafur

1978
[Comparative assessment of the effectiveness of the preparations CCNU, 5-fluorouracil, ftorafur and their combinations in inoperable stomach cancer].
    Vestnik Akademii meditsinskikh nauk SSSR, 1978, Issue:9

    Topics: Adenocarcinoma; Drug Therapy, Combination; Fluorouracil; Humans; Lomustine; Nitrosourea Compounds; Stomach Neoplasms; Tegafur

1978
[Synthesis of 3-(tetrahydro-2-furanyl)-5-fluorouracil (author's transl)].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1978, Volume: 98, Issue:11

    Topics: Antineoplastic Agents; Fluorouracil; Methods; Tegafur

1978
Pharmacokinetics and metabolism of ftorafur in man.
    Cancer treatment reports, 1979, Volume: 63, Issue:3

    Topics: Aged; Animals; Biotransformation; Chromatography, High Pressure Liquid; Female; Fluorouracil; Horses; Humans; In Vitro Techniques; Kinetics; Male; Middle Aged; Oxidation-Reduction; Rats; Tegafur; Thymidine Phosphorylase; Uridine Phosphorylase

1979
In vivo effects of 5-fluorouracil and ftorafur[1-(tetrahydrofuran-2-yl)-5-fluorouracil] on murine mammary tumors and small intestine.
    Cell and tissue kinetics, 1979, Volume: 12, Issue:2

    Topics: Animals; Body Weight; Cell Division; DNA; Female; Fluorouracil; Intestine, Small; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Tegafur

1979
[Clinical studies on FT-207 enteric-coated granule--clinico-pharmacological evaluation and clinical experience (author's transl)].
    Nihon Gan Chiryo Gakkai shi, 1979, Apr-20, Volume: 14, Issue:2

    Topics: Adult; Aged; Drug Evaluation; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Tablets, Enteric-Coated; Tegafur

1979
Post-operative long-term adjuvant immunochemotherapy with mitomycin-C, PSK and FT-207 in gastric cancer patients.
    The Japanese journal of surgery, 1979, Volume: 9, Issue:2

    Topics: Adjuvants, Immunologic; Basidiomycota; Drug Therapy, Combination; Fluorouracil; Gastrectomy; Humans; Immunotherapy; Mitomycins; Neoplasm Staging; Phytohemagglutinins; Postoperative Period; Proteoglycans; Skin Tests; Stomach Neoplasms; Tegafur; Time Factors; Tuberculin Test

1979
Phase II evaluation of ftorafur in previously untreated colorectal cancer: a Southwest Oncology Group Study.
    Cancer, 1979, Volume: 44, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Central Nervous System; Colonic Neoplasms; Drug Evaluation; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Metastasis; Rectal Neoplasms; Remission, Spontaneous; Tegafur; Time Factors

1979
Human urinary metabolites of 1-(tetrahydro-2-furanyl)-5-fluorouracil (ftoraful).
    Cancer research, 1979, Volume: 39, Issue:8

    Topics: Chemical Phenomena; Chemistry; Fluorouracil; Humans; Hydroxylation; Magnetic Resonance Spectroscopy; Mass Spectrometry; Tegafur

1979
[Effect of ftorafur and 5-fluorouracil on the chromosomes of human tumor cell cultures].
    Genetika, 1979, Volume: 15, Issue:5

    Topics: Cells, Cultured; Chromosome Deletion; Chromosomes, Human; Colonic Neoplasms; Fluorouracil; Humans; Karyotyping; Neoplasms; Tegafur

1979
Metabolism of 1,3-bis(tetrahydro-2-furanyl)-5-fluorouracil in mice.
    Journal of the National Cancer Institute, 1979, Volume: 63, Issue:2

    Topics: Animals; Fluorouracil; Half-Life; Kidney; Liver; Male; Mice; Phenobarbital; Tegafur

1979
Chemotherapy of gastrointestinal cancer.
    Acta hepato-gastroenterologica, 1979, Volume: 26, Issue:2

    Topics: Adjuvants, Pharmaceutic; Antineoplastic Agents; Fluorouracil; Gastrointestinal Neoplasms; Humans; Neoplasm Invasiveness; Neoplasm Metastasis; Prognosis; Tegafur

1979
Effect of coadministration of uracil or cytosine on the anti-tumor activity of clinical doses of 1-(2-tetrahydrofuryl)-5-fluorouracil and level of 5-fluorouracil in rodents.
    Gan, 1979, Volume: 70, Issue:2

    Topics: Administration, Oral; Animals; Cytosine; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Sarcoma 180; Tegafur; Tissue Distribution; Uracil

1979
Detailed analysis of chromosome aberrations in human leukocyte induced by anti-malignant tumor agent (FT-207).
    Yonsei medical journal, 1978, Volume: 19, Issue:1

    Topics: Cells, Cultured; Chromosome Aberrations; Female; Fluorouracil; Humans; Leukocytes; Male; Mitotic Index; Tegafur; Time Factors

1978
Ftorafur, adriamycin, cyclophosphamide and BCG in the treatment of metastatic breast cancer.
    Cancer, 1979, Volume: 44, Issue:2

    Topics: Adult; Aged; Antineoplastic Agents; BCG Vaccine; Body Weight; Breast Neoplasms; Central Nervous System; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Middle Aged; Tegafur; Vomiting

1979
Phase I-II study of ftorafur and methyl-CCNU in advanced colorectal cancer.
    Cancer, 1979, Volume: 44, Issue:3

    Topics: Adenocarcinoma; Adult; Aged; Bone Marrow; Colonic Neoplasms; Digestive System; Drug Evaluation; Drug Therapy, Combination; Fluorouracil; Humans; Middle Aged; Nervous System; Nitrosourea Compounds; Rectal Neoplasms; Semustine; Tegafur

1979
5-Fluorouracil concentrations in human plasma following R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) administration.
    Cancer research, 1979, Volume: 39, Issue:10

    Topics: Fluorouracil; Humans; Infusions, Parenteral; Neoplasms; Tegafur; Time Factors

1979
Evidence for toxicologic activity of ftorafur independent of conversion to 5-fluorouracil.
    Cancer treatment reports, 1979, Volume: 63, Issue:8

    Topics: Animals; Digestive System; Fluorouracil; Hyperplasia; Intestinal Mucosa; Male; Mice; Tegafur

1979
[Change of toxic and antineoplastic properties of ftorafur by means of action on nonspecific microsomal oxidase].
    Biulleten' eksperimental'noi biologii i meditsiny, 1979, Volume: 88, Issue:10

    Topics: Animals; Drug Antagonism; Drug Synergism; Enzyme Induction; Fluorouracil; Leukemia, Experimental; Methylcholanthrene; Mice; Microsomes; Oxidoreductases; Phenobarbital; Premedication; Proadifen; Rauscher Virus; Spleen; Tegafur

1979
A phase II trial of ftorafur: adriamycin and mitomycin-C (FAM II) in advanced gastric adenocarcinoma.
    Cancer, 1979, Volume: 44, Issue:4

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Bone Marrow; Central Nervous System; Digestive System; Doxorubicin; Drug Evaluation; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Middle Aged; Mitomycins; Remission, Spontaneous; Stomach Neoplasms; Tegafur

1979
Chemotherapy for gastric cancer.
    Frontiers of gastrointestinal research, 1979, Volume: 5

    Topics: Antineoplastic Agents; Drug Therapy, Combination; Fluorouracil; Humans; Mitomycins; Stomach Neoplasms; Tegafur

1979
Adriamycin, BCNU, ftorafur chemotherapy of pancreatic and biliary tract cancer.
    Cancer, 1979, Volume: 44, Issue:6

    Topics: Adult; Aged; Biliary Tract Neoplasms; Bone Marrow; Carmustine; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Middle Aged; Pancreatic Neoplasms; Remission, Spontaneous; Tegafur; Time Factors

1979
[Effect of ftorafur on the chromosomes of human normal and tumor cells in vitro].
    Genetika, 1979, Volume: 15, Issue:1

    Topics: Burkitt Lymphoma; Cells, Cultured; Chromosomes, Human; Dose-Response Relationship, Drug; Fluorouracil; Humans; Lymphocytes; Mitosis; Tegafur

1979
Chemoimmunotherapy with or without oophorectomy in premenopausal patients with advanced breast cancer.
    Journal of surgical oncology, 1979, Volume: 12, Issue:4

    Topics: BCG Vaccine; Breast Neoplasms; Castration; Cyclophosphamide; Doxorubicin; Drug Therapy; Female; Fluorouracil; Follow-Up Studies; Humans; Immunotherapy; Levamisole; Menopause; Neoplasm Metastasis; Tegafur

1979
Quantitative gas-liquid chromatographic determination of ftorafur and 5-fluorouracil in biological specimens.
    Analytical biochemistry, 1979, Sep-01, Volume: 97, Issue:2

    Topics: Animals; Chromatography, Gas; Fluorouracil; Gas Chromatography-Mass Spectrometry; Kinetics; Male; Mice; Tegafur; Water

1979
The metabolism of ftorafur in the beagle dog and rhesus monkey.
    Xenobiotica; the fate of foreign compounds in biological systems, 1977, Volume: 7, Issue:12

    Topics: Animals; Biotransformation; Dogs; Fluorouracil; Haplorhini; Macaca mulatta; Male; Tegafur; Time Factors

1977
[A comparative study on the preoperative administration of 5-FU DS and FD-1 against gastric cancer--with special reference to histological findings (author's transl)].
    Nihon Gan Chiryo Gakkai shi, 1979, Apr-20, Volume: 14, Issue:2

    Topics: Adult; Aged; Female; Fluorouracil; Furans; Humans; Lymphatic Metastasis; Male; Middle Aged; Preoperative Care; Pyrimidinones; Stomach; Stomach Neoplasms; Tegafur

1979
[Clinical pharmacokinetics of 2-C14-ftorafur in patients with astrocytoma].
    Voprosy onkologii, 1976, Volume: 22, Issue:7

    Topics: Astrocytoma; Blood-Brain Barrier; Brain Neoplasms; Cerebral Cortex; Fluorouracil; Humans; Injections, Intravenous; Tegafur

1976
Drugs that make cancer retreat.
    Indian journal of cancer, 1976, Volume: 13, Issue:3

    Topics: Antineoplastic Agents; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Nitrogen Mustard Compounds; Phenylalanine; Piperazines; Prospidium; Tegafur

1976
Comparison of 5-fluorouracil and ftorafur. I. Quantitative and qualitative differences in toxicity to mice.
    Cancer treatment reports, 1976, Volume: 60, Issue:9

    Topics: Animals; Blood Cell Count; Blood Platelets; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluorouracil; Half-Life; Immunity; Lethal Dose 50; Leukocytes; Male; Mice; Tegafur

1976
Comparison of 5-fluorouracil and ftorafur. II. Therapeutic response and development of resistance in murine tumors.
    Cancer treatment reports, 1976, Volume: 60, Issue:9

    Topics: Animals; Carcinoma; Cell Line; Drug Resistance; Drug Therapy, Combination; Female; Fluorouracil; Leukemia L1210; Leukemia, Experimental; Lung Neoplasms; Lymphoma, Non-Hodgkin; Male; Melanoma; Methotrexate; Mice; Neoplasms, Experimental; Tegafur

1976
[Comparative study of the effect of inhibitors of monoamine oxidase and ftorafur on the growth of de-differentiated astrocytoma].
    Arkhiv patologii, 1976, Volume: 38, Issue:6

    Topics: Animals; Astrocytoma; Cerebellar Neoplasms; Drug Evaluation; Fluorouracil; Monoamine Oxidase Inhibitors; Neoplasms, Experimental; Rats; Serotonin; Tegafur

1976
[Effect of millimeter band radio waves combined with ftorafur on the blood-forming system].
    Nauchnye doklady vysshei shkoly. Biologicheskie nauki, 1976, Issue:12

    Topics: Animals; Bone Marrow; Bone Marrow Cells; Depression, Chemical; Fluorouracil; Hematopoiesis; Male; Mice; Radio Waves; Tegafur

1976
Prognostic factors in patients with hepatocellular carcinoma receiving systemic chemotherapy.
    Hepatology (Baltimore, Md.), 1992, Volume: 16, Issue:1

    Topics: alpha-Fetoproteins; Analysis of Variance; Antineoplastic Agents; Ascites; Bilirubin; Carcinoma, Hepatocellular; Cisplatin; Doxorubicin; Etoposide; Female; Fluorouracil; Follow-Up Studies; Humans; Interferon-gamma; Liver Neoplasms; Male; Middle Aged; Mitoxantrone; Multivariate Analysis; Prognosis; Regression Analysis; Risk Factors; Serum Albumin; Tegafur; Time Factors

1992
Antitumor activity of two novel low immunosuppressive fluoropyrimidines UK-21 and UK-25.
    Japanese journal of pharmacology, 1992, Volume: 59, Issue:4

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Body Weight; Fluorouracil; Glycine; Leukemia L1210; Leukemia P388; Lung Neoplasms; Methylcholanthrene; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Neoplasms, Experimental; Organ Size; Sarcoma 180; Spleen; Tegafur; Thymus Gland; Uridine

1992
[Concentration of 5-fluorouracil in the blood and tissues of gastric and colo-rectal cancer patients after oral administration of UFT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:13

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Fluorouracil; Humans; Lymph Nodes; Stomach Neoplasms; Tegafur; Uracil

1992
[Blood concentrations of futraful, uracil and 5-fluorouracil (5-FU) after UFT administration in the various reconstructions after gastrectomy. Saitama UFT Research Group].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:13

    Topics: Anastomosis, Roux-en-Y; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Fluorouracil; Gastrectomy; Humans; Postoperative Period; Stomach Neoplasms; Tegafur; Uracil

1992
[A study of urinary tegafur, 5-fluorouracil (5-FU) and uracil concentrations in the cases of gastric carcinoma for the confirmation of drug-taking compliance after UFT oral administration].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:13

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Compliance; Fluorouracil; Gastrectomy; Humans; Postoperative Period; Stomach Neoplasms; Tegafur; Uracil

1992
Metabolism of tegafur in rat liver observed by in vivo 19F magnetic resonance spectroscopy and chromatography.
    Japanese journal of cancer research : Gann, 1992, Volume: 83, Issue:4

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chromatography, High Pressure Liquid; Fluorine; Fluorouracil; Gas Chromatography-Mass Spectrometry; Liver; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Inbred WKY; Tegafur

1992
[Trend and problems of chemotherapy of stomach neoplasms with metastasis].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1992, May-10, Volume: 81, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Fluorouracil; Humans; Mitomycin; Neoplasm Metastasis; Stomach Neoplasms; Tegafur

1992
Chemotherapy for colorectal carcinoma.
    Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:8 Suppl

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carmustine; Chemotherapy, Adjuvant; Colorectal Neoplasms; Drug Administration Schedule; Fluorouracil; Humans; Lomustine; Mitomycin; Tegafur

1992
Hyperthermia enhances the inhibition of tumor growth by 1-(2-tetrahydrofuryl)-5-fluorouracil/uracil (1:4) in tumors in mice and humans.
    Cancer, 1992, Sep-01, Volume: 70, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Combined Modality Therapy; Drug Combinations; Female; Fluorouracil; Humans; Hyperthermia, Induced; Male; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms, Experimental; Phosphorylation; Sarcoma 180; Tegafur; Tumor Cells, Cultured

1992
[Neo-adjuvant chemotherapy with tegafur suppository for rectal cancer--evaluation of the antitumor effects, tissue levels of 5-FU and inhibition of thymidylate synthase. Tochigi Colorectal Cancer Study Group].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:11

    Topics: Chemotherapy, Adjuvant; Female; Fluorouracil; Humans; Male; Rectal Neoplasms; Suppositories; Tegafur; Thymidylate Synthase

1992
Metabolism of 1-(2-tetrahydrofuryl)-5-fluorouracil to 5-fluorouracil in partially hepatectomized rats.
    Anti-cancer drugs, 1992, Volume: 3, Issue:2

    Topics: Animals; Fluorouracil; Hepatectomy; Liver; Male; Rats; Rats, Inbred Strains; Tegafur; Tissue Distribution

1992
[Histological evaluation of intra-arterial infusion and systemic chemotherapy of pancreatic carcinomas].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:3

    Topics: Adenocarcinoma; Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Fluorouracil; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Mitomycin; Neoplasm Staging; Pancreatic Neoplasms; Tegafur

1992
[Chemosensitivity of head and neck squamous cell carcinomas using subrenal capsule assay--comparative assay of 5-FU, FT, UFT, and HCFU and immunohistochemical study].
    Nihon Jibiinkoka Gakkai kaiho, 1992, Volume: 95, Issue:1

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Fluorouracil; Head and Neck Neoplasms; Immunohistochemistry; Male; Mice; Mice, Inbred C3H; Subrenal Capsule Assay; Tegafur; Uracil

1992
[Pharmacokinetic studies on fluorinated pyrimidine in cancer cell and tissue].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:4

    Topics: Animals; Carcinoma, Ehrlich Tumor; Colonic Neoplasms; Esophageal Neoplasms; Female; Fluorouracil; Glucaric Acid; Humans; Liver; Male; Mice; Pancreatic Neoplasms; Stomach Neoplasms; Tegafur

1992
[Pharmacokinetic study of tegafur in the hepatic tissue obtained from the patients with liver cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:5

    Topics: Aged; Colonic Neoplasms; Fluorouracil; Humans; Liver; Liver Neoplasms; Middle Aged; Stomach Neoplasms; Tegafur; Thymidylate Synthase

1992
[Thymidylate synthase inhibition and concentration of 5-fluorouracil after administration of UFT in human uroepithelial carcinomas].
    Hinyokika kiyo. Acta urologica Japonica, 1991, Volume: 37, Issue:3

    Topics: Adenocarcinoma, Mucinous; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Female; Fluorouracil; Humans; Male; Middle Aged; Tegafur; Thymidylate Synthase; Tissue Distribution; Uracil; Ureteral Neoplasms; Urinary Bladder Neoplasms

1991
[The dynamic indices of the natural killer cells in the chemotherapy of patients with digestive organ cancer].
    Vrachebnoe delo, 1990, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Digestive System Neoplasms; Female; Fluorouracil; Humans; Indomethacin; Interferons; Killer Cells, Natural; Male; Middle Aged; Tegafur

1990
Effects of combined therapies with protein-bound polysaccharide (PSK, Krestin) and fluorinated pyrimidine derivatives on experimental liver metastases and on the immunologic capacities of the hosts.
    Oncology, 1991, Volume: 48, Issue:6

    Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cytotoxicity, Immunologic; Dose-Response Relationship, Drug; Female; Fluorouracil; Hypersensitivity, Delayed; Immunity, Cellular; Kupffer Cells; Liver Neoplasms; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neoplasms, Experimental; Organ Size; Phagocytosis; Proteoglycans; Splenectomy; Tegafur; Thymus Gland

1991
[Comparative bioavailability of fluorouracil and its prodrug, ftorafur, following intra-arterial, intravenous and preoral administration].
    Die Pharmazie, 1991, Volume: 46, Issue:8

    Topics: Administration, Oral; Biological Availability; Fluorouracil; Half-Life; Humans; Injections, Intra-Arterial; Injections, Intravenous; Middle Aged; Prodrugs; Tegafur

1991
A protein-bound polysaccharide immunomodulator, PSK, does not suppress the conversion from 1-(2-tetrahydrofuryl)-5-fluorouracil to 5-fluorouracil in patients with gastric cancer.
    Anti-cancer drugs, 1991, Volume: 2, Issue:3

    Topics: Antibiotics, Antineoplastic; Biotransformation; Depression, Chemical; Female; Fluorouracil; Humans; Injections, Intravenous; Male; Middle Aged; Proteoglycans; Stomach Neoplasms; Tegafur

1991
Concentration of 5-fluorouracil in renal cells from cancer patients administered a mixture of 1-(2-tetrahydrofuryl)-5-fluorouracil and uracil.
    International journal of clinical pharmacology research, 1991, Volume: 11, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Fluorouracil; Humans; Kidney; Kidney Neoplasms; Tegafur; Uracil

1991
Induction of lethal infection with indigenous Escherichia coli in mice by fluorouracil.
    Canadian journal of microbiology, 1991, Volume: 37, Issue:3

    Topics: Administration, Oral; Animals; Cephalothin; Escherichia coli; Escherichia coli Infections; Fluorouracil; Intestines; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Specific Pathogen-Free Organisms; Streptomycin; Tegafur; Time Factors

1991
[Comparative studies on the antitumor activity of fluorinated pyrimidine derivatives against human bladder, cervical and ovarian cancer xenografts in nude mice].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1991, Volume: 18, Issue:10

    Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Female; Floxuridine; Fluorouracil; Humans; Mice; Mice, Nude; Ovarian Neoplasms; Tegafur; Uracil; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms

1991
Comparative antitumor activity of 5-fluorouracil and its prodrugs in combination with hyperthermia in vitro.
    Acta medica Okayama, 1991, Volume: 45, Issue:5

    Topics: Antineoplastic Agents; Cell Survival; Floxuridine; Fluorouracil; Hot Temperature; Humans; Infant, Newborn; Prodrugs; Tegafur; Tumor Cells, Cultured

1991
[Activation of tegafur by cultured rat hepatocytes].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1991, Volume: 18, Issue:10

    Topics: Animals; Cells, Cultured; Drug Evaluation, Preclinical; Fluorouracil; Liver; Male; Rats; Tegafur; Tissue Survival

1991
[Regional immunochemotherapy for liver metastasis of esophageal cancer in a patient with variant hepatic artery].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1991, Volume: 18, Issue:11

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Esophageal Neoplasms; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps; Infusions, Intra-Arterial; Injections, Intramuscular; Liver Neoplasms; Male; Middle Aged; Picibanil; Tegafur; Uracil

1991
Effect of L-cysteine on plasma concentration and urinary excretion of 1-(tetrahydro-2-furanyl)-5-fluorouracil metabolites.
    Chemical & pharmaceutical bulletin, 1991, Volume: 39, Issue:4

    Topics: Animals; Cysteine; Fluorouracil; Kidney Tubules; Male; Rats; Rats, Inbred Strains; Tegafur

1991
[Studies on 5-FU concentration in serum and prostate cancer tissue after oral administration of UFT].
    Hinyokika kiyo. Acta urologica Japonica, 1991, Volume: 37, Issue:7

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Humans; Male; Prostatectomy; Prostatic Neoplasms; Tegafur; Uracil

1991
Hepatic recurrence not prevented with low-dosage long-term intraportal 5-FU infusion after resection of colorectal liver metastasis.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 1991, Volume: 17, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Female; Fluorouracil; Hepatectomy; Humans; Infusions, Intravenous; Injections, Intravenous; Liver Neoplasms; Male; Middle Aged; Mitomycin; Neoplasm Recurrence, Local; Portal Vein; Tegafur; Time Factors

1991
[High-dose Tegafur (FT) for primary lung cancer: a phase I trial].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1991, Volume: 18, Issue:4

    Topics: Drug Administration Schedule; Drug Evaluation; Fluorouracil; Humans; Infusions, Intravenous; Lung Neoplasms; Middle Aged; Tegafur

1991
[Possible cardiotoxicity induced by orally administered fluoropyrimidines].
    Anales de medicina interna (Madrid, Spain : 1984), 1990, Volume: 7, Issue:10

    Topics: Administration, Oral; Aged; Fluorouracil; Heart Diseases; Humans; Male; Middle Aged; Tegafur

1990
[Usage of urine FT levels for medication compliance in head and neck cancer with administration of UFT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Male; Middle Aged; Tegafur; Uracil

1990
[Tissue UFT distribution and histological changes following UFT administration in metastatic liver cancer cases].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:7

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Female; Fluorouracil; Humans; Liver; Liver Neoplasms; Male; Middle Aged; Tegafur; Uracil

1990
[Macrocytic anemia as a possible adverse effect of fluoropyrimidines].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:8 Pt 1

    Topics: Anemia, Macrocytic; Antineoplastic Combined Chemotherapy Protocols; Erythrocyte Indices; Female; Fluorouracil; Folic Acid; Humans; Male; Retrospective Studies; Stomach Neoplasms; Tegafur; Uracil; Vitamin B 12

1990
[Evaluation of intraperitoneal cancer chemotherapy using an implantable reservoir in patients with peritonitis carcinomatosa].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:8 Pt 2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Ascitic Fluid; Cisplatin; Colorectal Neoplasms; Evaluation Studies as Topic; Female; Fluorouracil; Humans; Infusion Pumps, Implantable; Male; Middle Aged; Mitomycin; Mitomycins; Peritonitis; Prognosis; Stomach Neoplasms; Tegafur

1990
[Evaluation of subselective intraarterial infusion chemotherapy in advanced gastric cancer and recurrence case-evaluated on factors other than direct effects].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:8 Pt 2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Drug Administration Schedule; Female; Fluorouracil; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Lymphatic Metastasis; Male; Middle Aged; Mitomycin; Mitomycins; Neoplasm Recurrence, Local; Quality of Life; Stomach Neoplasms; Tegafur; Uracil

1990
[Results of prophylactic intra-arterial infusion chemotherapy after hepatic resection in colorectal metastases].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:8 Pt 2

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Fluorouracil; Hepatectomy; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms; Mitomycin; Mitomycins; Neoplasm Recurrence, Local; Postoperative Care; Tegafur; Uracil

1990
[Effects of combination chemotherapy with topical application of 5-FU ointment to mice's tongue and UFT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:9

    Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Liver; Male; Mice; Ointments; Tegafur; Tongue; Uracil

1990
[Combination chemotherapy of human renal cell carcinoma in athymic nude mice with human lymphoblastoid interferon (HLBI) and UFT, 5-Fu].
    Hinyokika kiyo. Acta urologica Japonica, 1990, Volume: 36, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Combined Modality Therapy; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Interferon Type I; Kidney Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Tegafur; Uracil

1990
In vivo 19F NMR spectroscopy of the antimetabolite 5-fluorouracil and its analogues. An assessment of drug metabolism.
    Biochemical pharmacology, 1990, Mar-01, Volume: 39, Issue:5

    Topics: Animals; Antineoplastic Agents; beta-Alanine; Carcinoid Tumor; Female; Floxuridine; Fluorouracil; Infusions, Intravenous; Liver; Magnetic Resonance Spectroscopy; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Tegafur

1990
[Chemotherapy with fluoropyrimidines for MOPC-104E plasmacytoma transplanted in mice with CCl4 induced chronic liver dysfunction].
    Nihon Gan Chiryo Gakkai shi, 1990, Mar-20, Volume: 25, Issue:3

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Floxuridine; Fluorouracil; Male; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Plasmacytoma; Tegafur; Uracil

1990
High-performance liquid chromatography with chemiluminescence detection of serum levels of pre-column derivatized fluoropyrimidine compounds.
    Journal of chromatography, 1990, Aug-24, Volume: 530, Issue:1

    Topics: Chromatography, High Pressure Liquid; Coumarins; Floxuridine; Fluorine; Fluorouracil; Humans; Molecular Structure; Pyrimidines; Tegafur; Umbelliferones; Uridine

1990
[Antitumor activity of UFT against murine renal cell carcinoma: a study on the suppression tumor metastases].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:10

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Drug Screening Assays, Antitumor; Female; Fluorouracil; Kidney Neoplasms; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Survival Rate; Tegafur; Uracil

1990
[Studies on 5-FU concentration and thymidine phosphorylase activity in tissues of patients with colorectal cancer after SF-SP administration].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:12

    Topics: Colorectal Neoplasms; Combined Modality Therapy; Delayed-Action Preparations; Fluorouracil; Humans; Portal Vein; Tegafur; Thymidine Phosphorylase; Tissue Distribution

1990
[Antineoplastic activity of combinations of cytostatics and dextran-ferrite administered to mice with leukemia P-388].
    Eksperimental'naia onkologiia, 1990, Volume: 12, Issue:6

    Topics: Animals; Antineoplastic Agents; Cisplatin; Cyclophosphamide; Dactinomycin; Daunorubicin; Doxorubicin; Drug Combinations; Fluorouracil; Iron-Dextran Complex; Leukemia P388; Melphalan; Methotrexate; Mice; Tegafur

1990
[Studies on the composition and stability constant of inclusion complexes of beta-cyclodextrin with fluorouracil and ftorafur by NMR].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1990, Volume: 25, Issue:5

    Topics: beta-Cyclodextrins; Cyclodextrins; Drug Carriers; Drug Combinations; Drug Stability; Fluorouracil; Magnetic Resonance Spectroscopy; Tegafur

1990
[Transformation of ovarian yolk sac tumor to immature teratoma following chemotherapy].
    Gan no rinsho. Japan journal of cancer clinics, 1985, Volume: 31, Issue:5

    Topics: Adult; alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Female; Fluorouracil; Humans; Mesonephroma; Mitomycin; Mitomycins; Ovarian Neoplasms; Tegafur; Teratoma; Uracil

1985
[Combined chemotherapy and radiotherapy in recurrent tumors of the head and neck region].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modality Therapy; Cyclophosphamide; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Male; Methotrexate; Neoplasm Recurrence, Local; Radiotherapy Dosage; Tegafur; Uracil

1987
[Plasma and tissue concentration of tegafur by a new soft capsule type suppository in colorectal carcinoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:1

    Topics: Aged; Aged, 80 and over; Capsules; Colorectal Neoplasms; Female; Fluorouracil; Humans; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Suppositories; Tegafur; Tissue Distribution

1989
[Long-term administration of tegafur in postoperative adjuvant chemotherapy in gastric cancer patients. Serial analysis of serum tegafur and 5-fluorouracil concentrations, and influence from PSK combination].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:1

    Topics: Adjuvants, Immunologic; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Fluorouracil; Gastrectomy; Humans; Male; Middle Aged; Proteoglycans; Stomach Neoplasms; Tegafur; Time Factors; Uracil

1989
[Experimental study on the effect of UFT with concomitant radiotherapy of uterine cervical cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bromodeoxyuridine; Carcinoma, Squamous Cell; Cell Division; Cell Line; Combined Modality Therapy; DNA Polymerase II; Female; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Tegafur; Tumor Cells, Cultured; Uracil; Uterine Cervical Neoplasms

1989
5-Fluorouracil and UFT-sensitive gastric carcinoma has a high level of thymidylate synthase.
    Cancer, 1989, May-01, Volume: 63, Issue:9

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Humans; Male; Mice; Mice, Inbred C3H; Stomach Neoplasms; Subrenal Capsule Assay; Tegafur; Thymidylate Synthase; Uracil

1989
[Conservative treatment of malignant liver tumors].
    Voprosy onkologii, 1989, Volume: 35, Issue:3

    Topics: Adult; Aged; Combined Modality Therapy; Female; Fluorouracil; Humans; Liver Neoplasms; Male; Methotrexate; Middle Aged; Particle Accelerators; Radiotherapy Dosage; Tegafur

1989
[The concentration of 5-fluorouracil in blood and tissues of the patients with carcinoma of the cervix after administration of UFT and 5-fluorouracil].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:4 Pt 1

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Female; Fluorouracil; Humans; Middle Aged; Tegafur; Tissue Distribution; Uracil; Uterine Cervical Neoplasms

1989
The uptake of anticancer drugs by tumor tissues and lymph node and the effectiveness of postoperative adjuvant chemotherapy on survival time.
    The Japanese journal of surgery, 1989, Volume: 19, Issue:2

    Topics: Combined Modality Therapy; Fluorouracil; Humans; Lymph Nodes; Prognosis; Stomach Neoplasms; Tegafur; Time Factors

1989
[Influence of OK-432 on intratumor 5-fluorouracil concentration in cases given UFT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biological Products; Biotransformation; Colonic Neoplasms; Fluorouracil; Humans; Lymphatic Metastasis; Picibanil; Stomach Neoplasms; Tegafur; Tissue Distribution; Uracil

1989
Pharmacokinetic modulation of plasma 5-fluorouracil concentrations to potentiate the antitumor activity of continuous venous infusion of 5-fluorouracil.
    Japanese journal of cancer research : Gann, 1989, Volume: 80, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Circadian Rhythm; Drug Synergism; Fluorouracil; Infusions, Intravenous; Kinetics; Leukocyte Count; Pyridines; Rats; Sarcoma, Yoshida; Tegafur; Uracil

1989
[Anti-tumor effect of fluoropyrimidines on human tumor cell lines transplanted in nude mice with CCl4-induced liver dysfunction].
    Nihon Geka Gakkai zasshi, 1989, Volume: 90, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carbon Tetrachloride; Cell Line; Colonic Neoplasms; Fluorouracil; Humans; Liver Cirrhosis, Experimental; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Stomach Neoplasms; Tegafur; Transplantation, Heterologous; Uracil

1989
[Effect of uracil on the both reactions, 5-fluorouracil degradation into 2-fluoro-beta-alanine and 5-fluorouracil splitting from tegafur in human tumor].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:8 Pt 1

    Topics: Adenocarcinoma, Papillary; Alanine; beta-Alanine; Fluorouracil; Humans; Lung Neoplasms; Tegafur; Tumor Cells, Cultured; Uracil

1989
Adjuvant effects of calmodulin antagonists on antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil (ftorafur) and a mixture of ftorafur and uracil (UFT) in nude mice bearing human ovarian carcinomas.
    Gynecologic oncology, 1989, Volume: 35, Issue:2

    Topics: Animals; Calmodulin; Carcinoma; Drug Combinations; Drug Synergism; Female; Fluorouracil; Mice; Mice, Nude; Neoplasm Transplantation; Ovarian Neoplasms; Sulfonamides; Tegafur; Time Factors; Uracil

1989
[Effect of cepharanthine on antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207)--5-fluorouracil delivery into tumor tissue].
    Nihon Gan Chiryo Gakkai shi, 1989, Jul-20, Volume: 24, Issue:7

    Topics: Alkaloids; Animals; Benzylisoquinolines; Drug Therapy, Combination; Fluorouracil; In Vitro Techniques; Male; Mice; Neoplasm Transplantation; Sarcoma 180; Tegafur; Tumor Cells, Cultured

1989
Distributions of tegafur in tissues of gastric adenocarcinoma patients: tissue uptakes and concentrations in plasma after oral and rectal administrations.
    Japanese journal of clinical oncology, 1989, Volume: 19, Issue:3

    Topics: Adenocarcinoma; Administration, Oral; Administration, Rectal; Adult; Aged; Female; Fluorouracil; Humans; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Stomach; Stomach Neoplasms; Suppositories; Tablets, Enteric-Coated; Tegafur; Tissue Distribution

1989
[Serum and tissue concentration of tegafur and 5-FU after administration of tegafur suppository in patients with lung cancer--correcting the influence of residual blood in the tissue].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:11

    Topics: Adult; Aged; Female; Fluorouracil; Humans; Lung; Lung Neoplasms; Male; Middle Aged; Suppositories; Tegafur; Tissue Distribution

1989
[Combination effect of UFT and gamma-irradiation against nude mice transplanted KB cells].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:11

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Fluorouracil; Gamma Rays; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mouth Neoplasms; Neoplasm Transplantation; Tegafur; Uracil

1989
[Study on the concentrations of 5-fluorouracil (5-FU), tegafur (ET) and uracil in bile: comparison of UFT or FT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:12

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bile; Biliary Tract Neoplasms; Cholestasis; Female; Fluorouracil; Humans; Male; Middle Aged; Tegafur; Uracil

1989
The discrepancy between immunocytochemical and biochemical assay of estrogen receptor in breast cancer patients treated by endocrine therapy.
    The Japanese journal of surgery, 1989, Volume: 19, Issue:6

    Topics: Adrenalectomy; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Humans; Ovariectomy; Receptors, Estrogen; Tamoxifen; Tegafur

1989
[The serum and tissue concentration of FT-207, 5'-DFUR and 5-FU in patients with breast cancer by preoperative administration of UFT and 5'-DFUR].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast; Breast Neoplasms; Floxuridine; Fluorouracil; Humans; Lymph Nodes; Preoperative Care; Tegafur; Tissue Distribution; Uracil

1989
Therapy of advanced gastric carcinoma. The Georgetown-Lombardi Cancer Center experience.
    American journal of clinical oncology, 1989, Volume: 12, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cisplatin; Doxorubicin; Fluorouracil; Folic Acid Antagonists; Humans; Middle Aged; Mitomycin; Mitomycins; Prognosis; Remission Induction; Stomach Neoplasms; Streptozocin; Tegafur; Triazines

1989
[Level of inhibition of thymidylate synthase activity and 5-fluorouracil in tumor tissues after administration of UFT or tegafur].
    Nihon Gan Chiryo Gakkai shi, 1989, Jul-20, Volume: 24, Issue:7

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Mice; Mice, Nude; Specific Pathogen-Free Organisms; Tegafur; Thymidylate Synthase; Uracil; Uterine Neoplasms

1989
[Study on the pharmacokinetics of UFT in patients with hepatocellular carcinoma associated with cirrhosis].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:9

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Female; Fluorouracil; Humans; Liver; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Tegafur; Thymidylate Synthase; Uracil

1989
[Preoperative chemotherapy for head and neck cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cisplatin; Fluorouracil; Head and Neck Neoplasms; Humans; Infusions, Intra-Arterial; Maxillary Neoplasms; Mouth Neoplasms; Peplomycin; Pharyngeal Neoplasms; Preoperative Care; Tegafur; Uracil

1985
[5-Fluorouracil, tegafur, and uracil concentrations in serum and tissue of the patients with hepatocellular carcinoma after UFT administration].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Drug Combinations; Fluorouracil; Humans; Liver Neoplasms; Tegafur; Uracil

1987
[Cancer chemotherapy of scirrhous type gastric cancer and evaluation of chemotherapeutic efficacy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:4 Pt 2-2

    Topics: Adenocarcinoma, Scirrhous; Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Fluorouracil; Humans; Injections, Intravenous; Mitomycin; Mitomycins; Radiography; Stomach Neoplasms; Tegafur; Uracil

1988
[Therapeutic treatment of Borrmann type 4 (scirrhous) gastric cancer-chemotherapy and histopathological studies].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:4 Pt 2-2

    Topics: Adenocarcinoma, Scirrhous; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Fluorouracil; Gastric Mucosa; Humans; Male; Middle Aged; Mitomycin; Mitomycins; Stomach; Stomach Neoplasms; Tegafur; Uracil

1988
Radiation therapy for advanced gastric cancer.
    International journal of radiation oncology, biology, physics, 1988, Volume: 15, Issue:1

    Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Adenocarcinoma, Papillary; Adult; Aged; Aged, 80 and over; Cobalt Radioisotopes; Female; Fluorouracil; Humans; Male; Middle Aged; Mitomycin; Mitomycins; Particle Accelerators; Radioisotope Teletherapy; Retrospective Studies; Stomach Neoplasms; Tegafur

1988
[Hormone therapy of breast cancer-its role in the treatment of breast cancer].
    Gan no rinsho. Japan journal of cancer clinics, 1985, Volume: 31, Issue:9 Suppl

    Topics: Breast Neoplasms; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Humans; Medroxyprogesterone; Medroxyprogesterone Acetate; Postoperative Care; Receptors, Estrogen; Tamoxifen; Tegafur

1985
The therapeutic effects of orally administered 5'-deoxy-5-fluorouridine, 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil on experimental murine tumors.
    Japanese journal of cancer research : Gann, 1985, Volume: 76, Issue:10

    Topics: Animals; Antineoplastic Agents; Floxuridine; Fluorouracil; Leukemia L1210; Mice; Neoplasms, Experimental; Tegafur

1985
[Observation on the curative effect postoperatively of late gastric cancer by the fu zheng anti-cancer method combined with chemotherapy].
    Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine, 1985, Volume: 5, Issue:10

    Topics: Adenocarcinoma; Adult; Aged; Combined Modality Therapy; Female; Fluorouracil; Humans; Male; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Middle Aged; Plant Extracts; Plants, Medicinal; Postoperative Care; Stomach Neoplasms; Tegafur

1985
[Effects of derivatives of Ara-C, 5-fluorouracil and nitrosourea against intracerebral implanted L1210 leukemia].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:2

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Brain Neoplasms; Cytarabine; Fluorouracil; Leukemia L1210; Mice; Neoplasm Transplantation; Nimustine; Nitrosourea Compounds; Streptozocin; Tegafur; Uracil

1987
[Combination chemotherapy with 3 or 4 drugs on human breast and gastrointestinal cancer xenografts in nude mice (II)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:5 Pt 1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Colonic Neoplasms; Cyclophosphamide; Doxorubicin; Female; Floxuridine; Fluorouracil; Humans; Methotrexate; Mice; Mice, Nude; Mitomycin; Mitomycins; Neoplasm Transplantation; Stomach Neoplasms; Tegafur; Vindesine

1987
[BOF-A1 and BOF-A2, new 5-FU degradation-inhibitory agents].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:7

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Floxuridine; Fluorouracil; Liver; Mice; Pyridines; Pyrimidines; Rats; Sarcoma 180; Sarcoma, Experimental; Sarcoma, Yoshida; Tegafur; Uracil

1987
[Comparative studies on the antitumor activity of the fluorinated pyrimidines 5'-DFUR, tegafur, UFT and FUra on various murine tumors].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Fluorouracil; Leukemia P388; Liver Neoplasms, Experimental; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Neoplasms, Experimental; Sarcoma 180; Tegafur; Uracil

1988
The antiproliferative effects of fluoropyrimidine derivatives against human tumor xenografts in a subrenal capsule assay.
    The Japanese journal of surgery, 1988, Volume: 18, Issue:6

    Topics: Animals; Antineoplastic Agents; Body Weight; Cell Division; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Male; Mice; Mice, Nude; Stomach Neoplasms; Subrenal Capsule Assay; Tegafur; Transplantation, Heterologous

1988
Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients.
    Cancer, 1985, Aug-15, Volume: 56, Issue:4

    Topics: Adolescent; Adult; Aged; Carcinoma, Hepatocellular; Embolization, Therapeutic; Female; Fluorouracil; Humans; Liver Neoplasms; Male; Middle Aged; Mitomycin; Mitomycins; Neoplasm Staging; Prognosis; Retrospective Studies; Tegafur; Time Factors

1985
[Blood level of 5-fluorouracil (5-FU) by oral administration of 1-hexylcarbamoyl-5-fluorouracil (HCFU) and tegafur in patients with hepatocellular carcinoma].
    Nihon Gan Chiryo Gakkai shi, 1985, Oct-20, Volume: 20, Issue:9

    Topics: Administration, Oral; Adult; Antineoplastic Agents; Carcinoma, Hepatocellular; Female; Fluorouracil; Humans; Liver Neoplasms; Male; Middle Aged; Tegafur

1985
[FT, 5-FU and uracil concentrations of the blood, bile and tissue of hepatoma with liver cirrhosis after oral administration of UFT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:4

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Bile; Carcinoma, Hepatocellular; Female; Fluorouracil; Humans; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Tegafur; Uracil

1987
Hepatic conversion of 1-(tetrahydro-2-furanyl)-5-fluorouracil into 5-fluorouracil in patients with hepatocellular carcinoma.
    Gastroenterologia Japonica, 1987, Volume: 22, Issue:1

    Topics: Aged; Carcinoma, Hepatocellular; Drug Therapy, Computer-Assisted; Fluorouracil; Humans; In Vitro Techniques; Injections, Intravenous; Kinetics; Liver Cirrhosis; Liver Neoplasms; Male; Microsomes, Liver; Middle Aged; Tegafur

1987
[UFT in the treatment of primary lung cancer--5-FU concentration in the tissue and side effects].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:6 Pt 1

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Female; Fluorouracil; Humans; Lung Neoplasms; Male; Middle Aged; Tegafur; Uracil

1987
N1-(2 tetrahydrofuryl)-5-fluorouracil (FT-207) in the postoperative adjuvant chemotherapy of gastric cancer. Delivery of a fat-emulsified agent to the lymph.
    Cancer, 1986, Feb-15, Volume: 57, Issue:4

    Topics: Adult; Aged; Antineoplastic Agents; Combined Modality Therapy; Fat Emulsions, Intravenous; Fluorouracil; Humans; Lymph; Male; Middle Aged; Postoperative Care; Stomach Neoplasms; Tegafur; Thoracic Duct

1986
Reversible leukoencephalopathy caused by 5-fluorouracil derivatives, presenting as akinetic mutism.
    Surgical neurology, 1986, Volume: 25, Issue:3

    Topics: Anal Gland Neoplasms; Animals; Breast Neoplasms; Carcinoma; Female; Fluorouracil; Humans; Leukoencephalopathy, Progressive Multifocal; Male; Middle Aged; Movement Disorders; Mutism; Tegafur; Tomography, X-Ray Computed

1986
[5-FU, FT-207 and uracil concentrations in the serum and tissues of patients with cervical cancer after UFT oral administration].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:2

    Topics: Administration, Oral; Adult; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Fluorouracil; Humans; Kinetics; Middle Aged; Ovary; Tegafur; Uracil; Uterine Cervical Neoplasms

1986
[5-FU concentration in blood and tissue of patients with primary lung cancer after oral administration of UFT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:3 Pt 1

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Humans; Lung; Lung Neoplasms; Male; Middle Aged; Tegafur; Uracil

1986
[Combined effects of radiation and 5-FU derivatives].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:3 Pt 1

    Topics: Adenocarcinoma; Animals; Cell Division; Fluorouracil; Male; Mice; Radiotherapy Dosage; Tegafur

1986
[Adjuvant therapy of gastric cancer in the literature from 1980-1984].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:5

    Topics: Antineoplastic Agents; Cyclophosphamide; Drug Administration Schedule; Fluorouracil; Humans; Mitomycin; Mitomycins; Neoplasm Staging; Postoperative Period; Stomach Neoplasms; Tegafur

1986
[Study on the concentration of FT-207 and 5-FU in serum and tissues of bladder tumor and prostatic carcinoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:6

    Topics: Adult; Aged; Fluorouracil; Humans; Male; Middle Aged; Prostate; Prostatic Neoplasms; Suppositories; Tegafur; Urinary Bladder; Urinary Bladder Neoplasms

1986
[The concentration in the tissue and antitumor effect of anticancer drug--assessment of breast cancer with UFT or FT-207].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast; Breast Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Humans; Tegafur; Uracil

1986
Potentiation of the chemotherapeutic action of tegafur against solid adenocarcinoma 755 by combination with L-cystine.
    Journal of cancer research and clinical oncology, 1986, Volume: 111, Issue:3

    Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Carbon Radioisotopes; Cysteine; Cystine; Drug Synergism; Fluorouracil; Male; Mice; Mice, Inbred Strains; Tegafur

1986
[Clinical study of THP-adriamycin in patients with advanced gastric cancer].
    Gan no rinsho. Japan journal of cancer clinics, 1986, Volume: 32, Issue:7

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Female; Fluorouracil; Humans; Male; Middle Aged; Stomach Neoplasms; Tegafur; Uracil

1986
[5-FU concentration in the blood and tissue of patients with gastric and colorectal cancer after administration of UFT or tegafur].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:8

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fluorouracil; Male; Rats; Rats, Inbred Strains; Rectal Neoplasms; Stomach Neoplasms; Tegafur; Uracil

1986
[Effects of krestin (PSK) on drug-metabolizing enzymes with special reference to the activation of FT-207].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:8

    Topics: Aminopyrine; Animals; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Fluorouracil; Mice; Mice, Inbred ICR; Microsomes, Liver; Propionibacterium acnes; Proteoglycans; Sarcoma 180; Tegafur

1986
[Influence of OK-432 on the concentration of active substance of fluoropyrimidine carcinostatics in the living body].
    Nihon Gan Chiryo Gakkai shi, 1986, May-20, Volume: 21, Issue:4

    Topics: Biological Products; Fluorouracil; Head and Neck Neoplasms; Humans; Picibanil; Tegafur

1986
[Comparison of continuous venous infusion of 5-FU and FT-207 under total parenteral nutrition].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:10

    Topics: Animals; Fluorouracil; Infusions, Intravenous; Male; Parenteral Nutrition, Total; Rats; Rats, Inbred Strains; Sarcoma, Yoshida; Tegafur

1986
[In vitro effects of 5-FU on gynecologic malignant tumor cell lines].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cell Line; Cells, Cultured; Colony-Forming Units Assay; Female; Fluorouracil; Humans; Ovarian Neoplasms; Tegafur; Tumor Stem Cell Assay; Uracil; Uterine Cervical Neoplasms

1986
[Serum and tissue concentrations of UFT in patients with lung cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Humans; Lung; Lung Neoplasms; Lymph Nodes; Lymphatic Metastasis; Tegafur; Uracil

1986
[Metabolism of tegafur in partial hepatectomized rats].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:10

    Topics: Animals; Cytochrome P-450 Enzyme System; Fluorouracil; Hepatectomy; Liver; Liver Regeneration; Male; Rats; Rats, Inbred Strains; Tegafur

1986
[Studies on oral-adjuvant chemotherapy of uterine cervical cancer after surgical treatment].
    Nihon Sanka Fujinka Gakkai zasshi, 1986, Volume: 38, Issue:9

    Topics: Adenocarcinoma; Administration, Oral; Carcinoma, Squamous Cell; Combined Modality Therapy; Drug Evaluation, Preclinical; Female; Fluorouracil; Humans; Neoplasm Recurrence, Local; Tegafur; Tumor Stem Cell Assay; Uterine Cervical Neoplasms

1986
Prognostic factors in metastatic carcinoma of unknown primary.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1986, Volume: 4, Issue:11

    Topics: Adenocarcinoma; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cisplatin; Cyclophosphamide; Dacarbazine; Doxorubicin; Drug Administration Schedule; Female; Fluorouracil; Humans; Male; Middle Aged; Mitomycin; Mitomycins; Neoplasms, Unknown Primary; Prognosis; Skin Neoplasms; Statistics as Topic; Tegafur; Vincristine

1986
[Effects of intravenous feeding on adjuvant chemotherapy--an experimental study on the distribution of 5-FU after injection of tegafur (1)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:1

    Topics: Animals; Fluorouracil; Liver; Lung Neoplasms; Male; Parenteral Nutrition; Rats; Rats, Inbred Strains; Tegafur; Tissue Distribution

1987
[Determination of the individual sensitivity of human stomach cancer cells to fluoropyrimidines by the cytomorphological criteria of heterotransplants in diffusion chambers].
    Eksperimental'naia onkologiia, 1986, Volume: 8, Issue:6

    Topics: Adenocarcinoma; Animals; Carcinoma; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Female; Fluorouracil; Humans; Male; Neoplasm Transplantation; Pyrimidines; Rats; Rats, Inbred Strains; Stomach Neoplasms; Tegafur; Time Factors; Transplantation, Heterologous; Tumor Stem Cell Assay

1986
[Chemosensitivity testing for 5-FU and 5-FU derivatives using subrenal capsule assay].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:3 Pt 1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Colony-Forming Units Assay; Fluorouracil; Humans; Lung Neoplasms; Stomach Neoplasms; Tegafur; Tumor Stem Cell Assay; Uracil

1987
[Concentration of 5-FU and tegafur in the ascites fluid in patients with peritonitis carcinomatosa after UFT oral administration].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:3 Pt 1

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Ascitic Fluid; Fluorouracil; Gastrointestinal Neoplasms; Humans; Peritonitis; Tegafur; Uracil

1987
Anticancer drug distribution in lymph and blood during adjuvant chemotherapy after surgery for gastric carcinoma. A study with a combined preparation of 1-(2-tetrahydrofuryl)-5-fluorouracil and uracil.
    Cancer, 1987, May-01, Volume: 59, Issue:9

    Topics: Combined Modality Therapy; Drug Combinations; Fluorouracil; Humans; Lymph; Male; Metabolic Clearance Rate; Middle Aged; Stomach Neoplasms; Tablets, Enteric-Coated; Tegafur; Uracil

1987
Intestinal absorption characteristics of 5-fluorouracil, ftorafur and 6-mercaptopurine in rats.
    Chemical & pharmaceutical bulletin, 1986, Volume: 34, Issue:10

    Topics: Animals; Fluorouracil; In Vitro Techniques; Intestinal Absorption; Kinetics; Male; Mercaptopurine; Rats; Rats, Inbred Strains; Tegafur

1986
[Studies on 5-FU concentration in serum and bladder tumor tissue after oral administration of UFT].
    Hinyokika kiyo. Acta urologica Japonica, 1986, Volume: 32, Issue:10

    Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Humans; Male; Middle Aged; Mucous Membrane; Tegafur; Uracil; Urinary Bladder; Urinary Bladder Neoplasms

1986
[The effect of gastrectomy on serum 5-FU concentrations of patients administered UFT per os].
    Gan no rinsho. Japan journal of cancer clinics, 1987, Volume: 33, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Fluorouracil; Gastrectomy; Humans; Male; Middle Aged; Postoperative Period; Stomach Neoplasms; Tegafur; Uracil

1987
[Improved quality of life in a patient with Borrmann type 4 gastric cancer treated with combination chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:6 Pt 1

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Humans; Methotrexate; Middle Aged; Mitomycin; Mitomycins; Picibanil; Prognosis; Quality of Life; Stomach Neoplasms; Tegafur; Uracil

1987
[FO-152].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:7

    Topics: Absorption; Adenocarcinoma; Animals; Antineoplastic Agents; Cell Line; Dogs; Drug Evaluation; Female; Fluorouracil; Humans; Leukemia L1210; Lung Neoplasms; Male; Mice; Stomach Neoplasms; Tegafur; Uridine

1987
[A study on UFT concentration in tissues and serum of patients with malignant gynecologic tumors following oral administration].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:7

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Genital Neoplasms, Female; Humans; Lymph Nodes; Ovary; Tegafur; Uracil; Uterus

1987
[Results of combined radiochemotherapy of intracranial ependymoma].
    No shinkei geka. Neurological surgery, 1987, Volume: 15, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cerebral Ventricle Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Ependymoma; Female; Fluorouracil; Follow-Up Studies; Humans; Infant; Infant, Newborn; Male; Middle Aged; Neoplasm Recurrence, Local; Nimustine; Nitrosourea Compounds; Tegafur

1987
[5-FU concentration in tumor tissue and the antitumor effect in patients with gastric cancer after oral administration of UFT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:9

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Humans; Male; Middle Aged; Stomach Neoplasms; Tegafur; Uracil

1987
Enhancing effect of bromovinyldeoxyuridine on antitumor activity of 5-fluorouracil and ftorafur against adenocarcinoma 755 in mice.
    European journal of cancer & clinical oncology, 1987, Volume: 23, Issue:6

    Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Bromodeoxyuridine; Cysteine; Drug Evaluation, Preclinical; Drug Synergism; Fluorouracil; Male; Mice; Tegafur

1987
[N1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) is metabolized and converted to 5-fluorouracil in tumor cells].
    Nihon Gan Chiryo Gakkai shi, 1987, Apr-20, Volume: 22, Issue:3

    Topics: Animals; Cells, Cultured; DNA, Neoplasm; Fluorouracil; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Tegafur

1987
[Serum concentration of 5-FU and tegafur (FT-207) after administration of tegafur (FT-207) suppository with the colostomy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:10

    Topics: Adult; Aged; Colostomy; Combined Modality Therapy; Female; Fluorouracil; Humans; Male; Middle Aged; Rectal Neoplasms; Stomach Neoplasms; Suppositories; Tegafur

1987
[Effects of intravenous alimentation on adjuvant chemotherapy--an experimental study on the distribution of 5-FU after injection of tegafur (2)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:10

    Topics: Animals; Fluorouracil; Injections, Intravenous; Lung Neoplasms; Parenteral Nutrition, Total; Rats; Tegafur; Tissue Distribution

1987
[The effect of tegafur suppository and glutathione in patients with gastric and colonic cancer with special reference to the histopathological anticancer effect].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:11

    Topics: Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Glutathione; Humans; Stomach Neoplasms; Suppositories; Tegafur

1987
[Tegafur and 5-FU concentrations in cancerous and normal tissues in nude mice after oral administration of UFT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:12

    Topics: Animals; Drug Combinations; Female; Fluorouracil; Kidney; Liver; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Tegafur; Time Factors; Tissue Distribution; Transplantation, Heterologous; Uracil; Urologic Neoplasms

1987
[Human colorectal carcinoma is more sensitive to HCFU than 5-FU and tegafur in in vitro and in vivo drug sensitivity tests].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:2

    Topics: Animals; Colonic Neoplasms; Fluorouracil; Humans; Mice; Rectal Neoplasms; Subrenal Capsule Assay; Tegafur; Tumor Cells, Cultured

1988
[Antitumor effect of UFT on human ovarian cancer grafted to nude mice and 5-FU concentration in tumor and normal tissues].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Ovarian Neoplasms; Tegafur; Tissue Distribution; Uracil

1988
[Antitumor effect of intermittent oral administration of UFT against human rectal cancer xenografted in nude mice].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:2

    Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Drug Administration Schedule; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Rectal Neoplasms; Tegafur; Uracil

1988
[A case of recurrent sigmoid colon cancer successfully treated with 5-FU and UFT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:3

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Humans; Lymphatic Metastasis; Middle Aged; Sigmoid Neoplasms; Tegafur; Uracil

1988
[Clinical study on the effect of chemotherapy in the treatment of pancreatic cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:4 Pt 1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Humans; Lymphatic Metastasis; Male; Middle Aged; Pancreatic Neoplasms; Prognosis; Tegafur; Uracil

1988
Sensitivity test for 5-fluorouracil and its analogues, 1-(2-tetrahydrofuryl)-5-fluorouracil, uracil/1-(2-tetrahydrofuryl)-5-fluorouracil (4:1) and 1-hexylcarbamoyl-5-fluorouracil, using the subrenal capsule assay.
    Oncology, 1988, Volume: 45, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Resistance; Fluorouracil; Gastrointestinal Neoplasms; Humans; Kidney; Male; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Subrenal Capsule Assay; Tegafur; Uracil

1988
[Inhibitory effect of UFT on postoperative lung metastasis of mammary adenocarcinoma in SHR rats].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:5

    Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Female; Fluorouracil; Lentinan; Lung Neoplasms; Mammary Neoplasms, Experimental; Rats; Rats, Inbred SHR; Tegafur; Uracil

1988
[Effects of OK-432 on UFT activation].
    Gan no rinsho. Japan journal of cancer clinics, 1988, Volume: 34, Issue:6

    Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Biological Products; Fluorouracil; Humans; Liver Neoplasms, Experimental; Male; Middle Aged; Neoplasms; Picibanil; Rats; Rats, Inbred Strains; Tegafur; Uracil

1988
[Experimental and clinical study of interactions between fluorinated pyrimidine derivatives and anticoagulants].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:8

    Topics: Animals; Anticoagulants; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Fluorouracil; Humans; Lung Neoplasms; Neoplasm Transplantation; Pyrimidines; Rats; Rats, Inbred Strains; Tegafur; Ticlopidine; Uracil; Warfarin

1988
[Uptake of anticancer drugs by target organs and the usefulness of adjuvant chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Female; Fluorouracil; Gastrectomy; Humans; Lymph Nodes; Male; Middle Aged; Postoperative Period; Prognosis; Stomach Neoplasms; Tegafur

1988
[Combined effects of interferon alpha-A/D with fluoropyrimidine derivatives in the subrenal capsule assay].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:8

    Topics: Animals; Colonic Neoplasms; Drug Synergism; Fluorouracil; Interferon Type I; Male; Mice; Mice, Nude; Neoplasm Transplantation; Stomach Neoplasms; Subrenal Capsule Assay; Tegafur

1988
[The serum and tissue concentrations of tegafur, 5-fluorouracil and uracil in patients with gastric and colorectal cancers after oral administration of UFT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:8

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fluorouracil; Humans; Rectal Neoplasms; Stomach Neoplasms; Tegafur; Uracil

1988
[MQF-FT and MQF-UFT in gallbladder and bile duct cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:9

    Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Carbazilquinone; Drug Administration Schedule; Female; Fluorouracil; Gallbladder Neoplasms; Humans; Infusions, Intravenous; Male; Middle Aged; Mitomycin; Mitomycins; Picibanil; Tegafur; Uracil

1988
[Complete response in a case of unresectable gastric cancer with a combination of tegafur, 5-fluorouracil and mitomycin C].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:9

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Liver Neoplasms; Male; Mitomycin; Mitomycins; Remission Induction; Stomach Neoplasms; Tegafur

1988
[Inflammatory breast carcinoma--possibilities and results of surgical treatment and adjuvant chemotherapy, especially when done preoperatively].
    Archiv fur Geschwulstforschung, 1988, Volume: 58, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Humans; Lymphatic Metastasis; Methotrexate; Neoplasm Metastasis; Preoperative Care; Tegafur; Time Factors

1988
Effect of PSK, a protein-bound polysaccharide from Coriolus versicolor, on drug-metabolizing enzymes in sarcoma-180 bearing and normal mice.
    International journal of immunopharmacology, 1988, Volume: 10, Issue:4

    Topics: Adjuvants, Immunologic; Animals; Antibiotics, Antineoplastic; Female; Fluorouracil; Liver; Mice; Mice, Inbred ICR; Pharmaceutical Preparations; Propionibacterium acnes; Proteoglycans; Sarcoma 180; Tegafur

1988
[Blood and tumor levels of tegafur, 5-fluorouracil, and uracil].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:11

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Fluorouracil; Humans; Male; Middle Aged; Stomach Neoplasms; Tegafur; Uracil

1988
[Pre- and post-operative adjuvant chemotherapy of colorectal cancer. Part 1. Drug concentration in tissues following UFT administration].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Fluorouracil; Humans; Postoperative Period; Tegafur; Uracil

1988
[Clinical studies of the treatment of bladder tumor and its effects--experience in 86 cases].
    Hinyokika kiyo. Acta urologica Japonica, 1988, Volume: 34, Issue:9

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Combined Modality Therapy; Doxorubicin; Female; Fluorouracil; Humans; Male; Middle Aged; Mitomycin; Mitomycins; Picibanil; Prognosis; Tegafur; Uracil; Urinary Bladder Neoplasms

1988
[Treatment of pancreatitis by electrophoresis of cytostatics].
    Vestnik khirurgii imeni I. I. Grekova, 1988, Volume: 141, Issue:7

    Topics: Acute Disease; Adult; Aged; Chronic Disease; Female; Fluorouracil; Humans; Iontophoresis; Male; Middle Aged; Pancreatitis; Tegafur; Ultrasonic Therapy

1988
UFT is more antineoplastic against gastric carcinoma than 5-fluorouracil, 1-(2-tetrahydrofuryl)-5-fluorouracil and 1-hexylcarbamoyl-5-fluorouracil.
    Chemotherapy, 1988, Volume: 34, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Male; Mice; Stomach Neoplasms; Subrenal Capsule Assay; Tegafur; Uracil

1988
[A case of variant angina induced by 5-fluorouracil and Tegafur].
    Kokyu to junkan. Respiration & circulation, 1988, Volume: 36, Issue:11

    Topics: Adenocarcinoma; Angina Pectoris, Variant; Coronary Vasospasm; Electrocardiography; Fluorouracil; Humans; Male; Middle Aged; Stomach Neoplasms; Tegafur

1988
[Level of 5-fluorouracil in cancerous and normal tissues of nude mice bearing human endometrial carcinoma after administration of UFT coadministered with nicardipin].
    Nihon Gan Chiryo Gakkai shi, 1988, Dec-20, Volume: 23, Issue:11

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Nicardipine; Tegafur; Transplantation, Heterologous; Uracil; Uterine Neoplasms

1988
A mechanism for the potentiation of the cytotoxic effects of antimetabolites drugs (FT-207, 5FU) by hyperthermia.
    Research communications in chemical pathology and pharmacology, 1988, Volume: 62, Issue:2

    Topics: Cell Line; Cell Survival; Colonic Neoplasms; Combined Modality Therapy; Cytosol; Fluorouracil; Hot Temperature; Humans; Membrane Potentials; Succinate Dehydrogenase; Tegafur; Tumor Cells, Cultured; Tumor Stem Cell Assay

1988
[Chemotherapy of pancreatic cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:2

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Doxorubicin; Female; Fluorouracil; Humans; Male; Middle Aged; Mitomycin; Mitomycins; Pancreatic Neoplasms; Streptozocin; Tegafur

1985
[Clinical study on the permeability of FT-207 and 5-FU in primary lung cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Carcinoma, Squamous Cell; Cell Membrane Permeability; Female; Fluorouracil; Humans; Infusions, Parenteral; Lung; Lung Neoplasms; Male; Middle Aged; Permeability; Suppositories; Tegafur

1985
[Intra-arterial infusion chemotherapy using a subcutaneously implanted silicone reservoir--with reference to the chemotherapy protocol].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:2

    Topics: Abdominal Neoplasms; Aged; Antineoplastic Combined Chemotherapy Protocols; Catheterization; Cytarabine; Female; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Mitomycin; Mitomycins; Silicone Elastomers; Stomach Neoplasms; Tegafur; Uracil

1985
[5-FU concentration in blood and tissue of patients with renal cell carcinoma after administration of UFT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Fluorouracil; Humans; Kidney Neoplasms; Tegafur; Uracil

1985
[A cooperative study of alternating immunochemotherapy with futraful and PSK (second report)--3-year survival rate].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:2

    Topics: Adjuvants, Immunologic; Administration, Oral; Drug Administration Schedule; Fluorouracil; Gastrectomy; Humans; Postoperative Care; Proteoglycans; Stomach Neoplasms; Tegafur

1985
Phase I and pharmacologic study of oral ftorafur and X ray therapy in advanced gastrointestinal cancer.
    International journal of radiation oncology, biology, physics, 1985, Volume: 11, Issue:3

    Topics: Administration, Oral; Adult; Aged; Combined Modality Therapy; Drug Evaluation; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Tegafur

1985
[Effect of intravenous administration of FT-207 for gastric cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:4

    Topics: Drug Administration Schedule; Female; Fluorouracil; Humans; Infusions, Parenteral; Lymph Nodes; Male; Stomach Neoplasms; Tegafur

1985
[Influence of immunopotentiators on the activation of 5-FU derivatives].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:4

    Topics: Adjuvants, Immunologic; Animals; Biological Products; Cytochrome P-450 Enzyme System; Fluorouracil; In Vitro Techniques; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Picibanil; Proteoglycans; Rats; Rats, Inbred Strains; Tegafur

1985
[A case of complete regression of gastric carcinoma and liver metastases by treatment with tegafur].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:4

    Topics: Adenocarcinoma; Aged; Fluorouracil; Humans; Liver Neoplasms; Male; Stomach Neoplasms; Tegafur

1985
[Preoperative chemotherapy for advanced breast cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Humans; Infusions, Intra-Arterial; Mitomycin; Mitomycins; Preoperative Care; Tegafur

1985
[Phase II study of sustained released granules of tegafur (SF-SP) on inoperable or recurrent gastric cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:5

    Topics: Adenocarcinoma; Adult; Aged; Delayed-Action Preparations; Drug Administration Schedule; Drug Evaluation; Female; Fluorouracil; Humans; Male; Middle Aged; Stomach Neoplasms; Tegafur

1985
[Preoperative treatment with UFT for patients with ovarian malignant tumors].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Humans; Middle Aged; Ovarian Neoplasms; Ovary; Preoperative Care; Tegafur; Uracil

1985
[Clinical study on concentration of FT-207 and 5-FU in serum, lymph nodes and tissues after rectal administration of FT-207 suppositories for malignant diseases of the liver, biliary tract and pancreas].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:5

    Topics: Biliary Tract Neoplasms; Fluorouracil; Humans; Liver Neoplasms; Lymph Nodes; Pancreatic Neoplasms; Preoperative Care; Rectum; Suppositories; Tegafur

1985
[Level of 5-FU in cancerous and normal tissues of nude mice after oral administration of tegafur coadministered with uracil (UFT)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:5

    Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Female; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Tegafur; Uracil; Uterine Neoplasms

1985
[5-FU concentration in the tissues (tumor and lymph node) of breast cancer patients given preoperative administration of UFT and FT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast; Breast Neoplasms; Female; Fluorouracil; Humans; Lymph Nodes; Preoperative Care; Tegafur; Uracil

1985
[Thermotherapy for cancer of the urinary bladder in combination with tegafur suppository and picibanil--concentrations of tegafur in the serum and tissues in bladder carcinoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:5

    Topics: Adult; Aged; Biological Products; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Female; Fluorouracil; Humans; Hyperthermia, Induced; Male; Middle Aged; Picibanil; Suppositories; Tegafur; Urinary Bladder; Urinary Bladder Neoplasms

1985
Cyclic combination chemotherapy in advanced adenocarcinoma of the lung: comparison of two FAM schedules.
    Cancer chemotherapy and pharmacology, 1985, Volume: 14, Issue:3

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Female; Fluorouracil; Humans; Lung Neoplasms; Male; Middle Aged; Mitomycin; Mitomycins; Tegafur

1985
[Metabolism of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) in human maxillary cancer (OKK) cells in culture].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:6

    Topics: Cell Division; Cells, Cultured; Chromatography, Thin Layer; Cytosol; Fluorouracil; Humans; Maxillary Neoplasms; Tegafur

1985
Effects of a fluorinated pyrimidinedione anti-cancer drug, 5-fluoro-1-(tetrahydro-2-furanyl)-2,4-pyrimidinedione (FT), and related compounds on nigro-striatal dopaminergic neurons in the central nervous system.
    Archives internationales de pharmacodynamie et de therapie, 1985, Volume: 274, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Methyltyrosine; Animals; Antineoplastic Agents; Corpus Striatum; Dopamine; Fluorouracil; Haloperidol; Homovanillic Acid; Male; Methyltyrosines; Motor Activity; Neurons; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Substantia Nigra; Tegafur; Time Factors; Uracil

1985
Relevance of the pharmacology of oral tegafur to its use as a 5-FU pro-drug.
    Cancer treatment reports, 1985, Volume: 69, Issue:6

    Topics: Administration, Oral; Fluorouracil; Gastrointestinal Neoplasms; Humans; Injections, Intravenous; Kinetics; Tegafur

1985
Long-term survivors of colorectal cancer with unresectable hepatic metastases.
    Diseases of the colon and rectum, 1985, Volume: 28, Issue:8

    Topics: Administration, Oral; Aged; Carcinoembryonic Antigen; Colonic Neoplasms; Female; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Mitomycin; Mitomycins; Rectal Neoplasms; Tegafur

1985
[Evaluation of combined radiotherapy of gastric carcinoma].
    Gan no rinsho. Japan journal of cancer clinics, 1985, Volume: 31, Issue:5

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Fluorouracil; Humans; Male; Middle Aged; Prognosis; Radiotherapy, High-Energy; Stomach Neoplasms; Tegafur

1985
[Comparison of the concentration of HCFU, tegafur and 5-FU in the thoracic duct lymph after oral administration of HCFU and tegafur].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:8

    Topics: Administration, Oral; Female; Fluorouracil; Humans; Lymph; Middle Aged; Tegafur; Thoracic Duct

1985
[A case of advanced male breast cancer treated effectively with estrogen].
    Gan no rinsho. Japan journal of cancer clinics, 1985, Volume: 31, Issue:7

    Topics: Adenocarcinoma; Administration, Oral; Antineoplastic Agents; Breast Neoplasms; Combined Modality Therapy; Diethylstilbestrol; Drug Administration Schedule; Fluorouracil; Humans; Male; Middle Aged; Tegafur

1985
[A case of advanced gastric cancer showing complete cure by immunochemotherapy with FT-207 and OK-432 confirmed by thorough histologic examination of total gastrectomy matter].
    Gan no rinsho. Japan journal of cancer clinics, 1985, Volume: 31, Issue:7

    Topics: Adenocarcinoma; Biological Products; Female; Fluorouracil; Gastrectomy; Humans; Injections, Intradermal; Middle Aged; Picibanil; Stomach; Stomach Neoplasms; Suppositories; Tegafur

1985
[Chemotherapy with FT-207 suppository (Futraful Supo) in head and neck cancer--cooperative studies by six medical schools in Kanagawa Prefecture].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:9

    Topics: Adult; Aged; Anorexia; Carcinoma, Squamous Cell; Drug Administration Schedule; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Male; Middle Aged; Nausea; Nose Neoplasms; Paranasal Sinus Neoplasms; Suppositories; Tegafur; Thyroid Neoplasms

1985
[A study on plasma and tissue 5-FU concentrations in patients with cervical cancer treated with UFT].
    Nihon Gan Chiryo Gakkai shi, 1985, Apr-20, Volume: 20, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Humans; Tegafur; Uracil; Uterine Cervical Neoplasms

1985
[Comparison between FT-207 and 5-FU on intravesical absorption--experimental study on intravesical absorption in the dog].
    Hinyokika kiyo. Acta urologica Japonica, 1985, Volume: 31, Issue:7

    Topics: Absorption; Animals; Dogs; Fluorouracil; Molecular Weight; Tegafur; Urinary Bladder

1985
[Level of 5-FU in uterine cervical cancer tissue after oral administration of UFT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:11

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cervix Uteri; Female; Fluorouracil; Humans; Middle Aged; Tegafur; Uracil; Uterine Cervical Neoplasms

1985
[A case of long-term survival of liver metastasis of breast cancer successfully treated with chemotherapy and endocrine therapy].
    Gan no rinsho. Japan journal of cancer clinics, 1985, Volume: 31, Issue:11

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Biopsy, Needle; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Humans; Liver; Liver Neoplasms; Lymph Node Excision; Lymphatic Metastasis; Methotrexate; Middle Aged; Tamoxifen; Tegafur

1985
[5-FU concentration in tissues of gastric cancer patients with preoperative administration of UFT--especially in comparison with FT-207].
    Gan no rinsho. Japan journal of cancer clinics, 1985, Volume: 31, Issue:13

    Topics: Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Humans; Levamisole; Stomach Neoplasms; Tegafur; Time Factors; Uracil

1985
[A case of toxic leucoencephalopathy induced by 5FU derivatives].
    No shinkei geka. Neurological surgery, 1985, Volume: 13, Issue:11

    Topics: Antineoplastic Agents; Brain; Brain Diseases; Breast Neoplasms; Female; Fluorouracil; Humans; Middle Aged; Tegafur

1985
Diffusion of anti-tumor drugs through membranes from hydrophilic methacrylate gels.
    Journal of biomedical materials research, 1974, Volume: 8, Issue:1

    Topics: Acrylates; Acrylic Resins; Antineoplastic Agents; Diffusion; Fluorouracil; Glycine; Membranes, Artificial; Mercaptopurine; Methacrylates; Polyhydroxyethyl Methacrylate; Purines; Sulfides; Tegafur; Valerates

1974
Ftorafur therapy in acute pancreatitis.
    Acta physiologica Hungarica, 1984, Volume: 64, Issue:3-4

    Topics: Acute Disease; Adult; Aged; Amylases; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Middle Aged; Pancreatic Function Tests; Pancreatitis; Tegafur

1984
Effects of 1,3-bis(tetrahydro-2-furanyl)-5-fluoro-2,4-pyrimidinedione (FD 1) on the central nervous system: (2) Effects on nigro-striatal dopaminergic neurons.
    Archives internationales de pharmacodynamie et de therapie, 1981, Volume: 252, Issue:1

    Topics: alpha-Methyltyrosine; Aminooxyacetic Acid; Animals; Antineoplastic Agents; Bicuculline; Corpus Striatum; Dopamine; Fluorouracil; Male; Methyltyrosines; Neurons; Picrotoxin; Rats; Receptors, Cell Surface; Receptors, GABA-A; Substantia Nigra; Tegafur; Tyrosine 3-Monooxygenase

1981
Potentiation of the antitumor activity of tegafur in sarcoma 180-bearing mice by chlordiazepoxide, diazepam and oxazepam.
    Chemical & pharmaceutical bulletin, 1983, Volume: 31, Issue:7

    Topics: Animals; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Drug Synergism; Fluorouracil; Male; Mice; Oxazepam; Sarcoma 180; Tegafur

1983
[FAR therapy in brain tumors--FT207-vitamin A-Radiation therapy (author's transl)].
    Neurologia medico-chirurgica, 1980, Volume: 20, Issue:5

    Topics: Adolescent; Adult; Astrocytoma; Brain Neoplasms; Child; Child, Preschool; Drug Therapy, Combination; Female; Fluorouracil; Glioma; Humans; Infant; Male; Medulloblastoma; Middle Aged; Radiotherapy Dosage; Tegafur; Vitamin A

1980
[Autoradiography studies of cell proliferation and the effect of cytostatic agents on the proliferation of normal and tumor cells].
    Acta histochemica. Supplementband, 1983, Volume: 27

    Topics: Animals; Antineoplastic Agents; Autoradiography; Bleomycin; Carcinoma, Ehrlich Tumor; Cell Cycle; Cell Division; Fluorouracil; Jejunum; Mice; Rats; Tegafur; Thymidine; Vincristine

1983
[Clinical evaluation of chemotherapeutic agents in the treatment of primary liver cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:9

    Topics: Adult; Aged; alpha-Fetoproteins; Carcinoma, Hepatocellular; Drug Therapy, Combination; Female; Fluorouracil; Humans; Liver Neoplasms; Male; Middle Aged; Mitomycin; Mitomycins; Tegafur

1982
Multidisciplinary treatment for esophageal carcinoma.
    Japanese journal of clinical oncology, 1983, Volume: 13, Issue:2

    Topics: Adult; Age Factors; Aged; Bleomycin; Esophageal Neoplasms; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Metastasis; Radiography; Tegafur

1983
[Pharmacokinetics study of UFT in malignant brain tumor patients].
    Neurologia medico-chirurgica, 1983, Volume: 23, Issue:8

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Drug Combinations; Female; Fluorouracil; Glioma; Humans; Kinetics; Male; Middle Aged; Tegafur; Uracil

1983
Chemotherapy in advanced urinary bladder cancer.
    Urology, 1984, Volume: 23, Issue:3 Suppl

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cisplatin; Combined Modality Therapy; Doxorubicin; Drug Evaluation; Fluorouracil; Humans; Lymphatic Metastasis; Mitomycin; Mitomycins; Tegafur; Urinary Bladder Neoplasms

1984
[Cancer of the maxillary antrum--a new multidisciplinary treatment containing neo-adjuvant chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:6

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Male; Maxillary Neoplasms; Middle Aged; Peplomycin; Tegafur; Uracil

1984
Studies on the designing of chemotherapy for gastric cancer in man, based on the tumor tissue concentration of anticancer agents.
    Gastroenterologia Japonica, 1982, Volume: 17, Issue:4

    Topics: Antineoplastic Agents; Floxuridine; Fluorouracil; Gastric Mucosa; Humans; Stomach Neoplasms; Tegafur

1982
[Pharmacological and pharmacodynamic aspects of cancer chemotherapy, with special reference to 5-fluorouracil and its derivatives].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Floxuridine; Fluorouracil; Humans; Kinetics; Neoplasms; Tegafur; Uracil

1982
[Immunochemotherapy with tegafur and schizophyllan for stomach cancer--report of 2 cases].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:9

    Topics: Aged; Drug Therapy, Combination; Female; Fluorouracil; Glycosaminoglycans; Humans; Male; Middle Aged; Sizofiran; Stomach Neoplasms; Tegafur

1983
Occurrence of induced 6-thioguanine-resistant colonies in synchronized V79 cells after treatment with ftorafur. Effects of the S9 fraction.
    Neoplasma, 1984, Volume: 31, Issue:3

    Topics: Animals; Cell Cycle; Cell Line; Cricetinae; Drug Resistance; Floxuridine; Fluorouracil; Male; Microsomes, Liver; Mutation; Tegafur; Thioguanine

1984
[Development of fluoropyrimidine derivatives].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:11

    Topics: Animals; DNA Replication; Floxuridine; Fluorouracil; Mice; Phosphorylation; Pyrimidine Nucleotides; Rats; Sarcoma, Experimental; Tegafur; Uracil

1984
Pharmacokinetics of ftorafur after intravenous and oral administration.
    Cancer chemotherapy and pharmacology, 1983, Volume: 10, Issue:3

    Topics: Administration, Oral; Adult; Aged; Carcinoma, Hepatocellular; Female; Fluorouracil; Half-Life; Humans; Injections, Intravenous; Kinetics; Liver Function Tests; Liver Neoplasms; Male; Middle Aged; Tegafur

1983
[5-FU concentration in brain tumors after co-administration of FT and uracil].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:4 Pt 1

    Topics: Brain Neoplasms; Drug Therapy, Combination; Fluorouracil; Glioblastoma; Humans; Meningeal Neoplasms; Meningioma; Tegafur; Uracil

1983
[Clinical study on preoperative chemotherapy of primary breast cancer. 2--A comparative study of CPA + FT-207 (5-FUDS) and CPA + FT-207 (5-FUDS) + MMC].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:6

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Papillary; Cyclophosphamide; Drug Therapy, Combination; Fluorouracil; Humans; Middle Aged; Mitomycin; Mitomycins; Preoperative Care; Tegafur

1983
[Antineoplastic effect of UFT therapy (uracil-FT-207 combination therapy) on experimental pancreatic cancer transplanted in the pancreas and subcutaneous region].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:12

    Topics: Animals; Antineoplastic Agents; Carcinoma, Intraductal, Noninfiltrating; Cricetinae; Drug Therapy, Combination; Fluorouracil; Male; Mesocricetus; Neoplasm Transplantation; Neoplasms, Experimental; Pancreatic Neoplasms; Tegafur; Tissue Distribution; Transplantation, Homologous; Uracil

1982
[Pre- and intra-operative chemotherapy using FT-207 suppositories--with special reference to lung cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:12

    Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Fluorouracil; Humans; Intraoperative Care; Lung Neoplasms; Preoperative Care; Suppositories; Tegafur

1982
[Sequential changes in blood concentrations of tegafur and 5-FU during oral administration of fine granules of tegafur in patients with primary liver cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:3

    Topics: Administration, Oral; Antineoplastic Agents; Carcinoma, Hepatocellular; Female; Fluorouracil; Humans; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Tegafur

1982
[Cerebrospinal fluid distributions of systemically administered fluorinated pyrimidines].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:3

    Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Ependymoma; Female; Fluorouracil; Glioblastoma; Humans; Male; Middle Aged; Tegafur

1983
[Experimental studies on the enhancing effects of the combined therapy with tegafur and cytochrome C].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:9

    Topics: Animals; Carbon Tetrachloride Poisoning; Cytochrome c Group; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Lethal Dose 50; Male; Neoplasms, Experimental; Rats; Tegafur

1983
[Clinical trial on the effect of tegafur (SF-SP)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:5

    Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Capsules; Carcinoma, Intraductal, Noninfiltrating; Colonic Neoplasms; Delayed-Action Preparations; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Pancreatic Neoplasms; Stomach Neoplasms; Tegafur

1984
Continuous intravenous administration of 1-(2-tetrahydrofuryl)-5-fluorouracil [FT] by intravenous hyperalimentation (IVH)--stability of FT in IVH solution and tumor levels of 5-fluorouracil (5-FU).
    Japanese journal of clinical oncology, 1983, Volume: 13, Issue:1

    Topics: Colonic Neoplasms; Dose-Response Relationship, Drug; Fluorouracil; Humans; Parenteral Nutrition, Total; Rectal Neoplasms; Tegafur; Time Factors

1983
Phase II study of ftorafur in previously untreated and treated patients with advanced colorectal cancer.
    Cancer treatment reports, 1983, Volume: 67, Issue:5

    Topics: Adenocarcinoma; Adult; Aged; Colonic Neoplasms; Drug Evaluation; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Metastasis; Rectal Neoplasms; Tegafur

1983
[Single chemotherapy with 5-fluorouracil or ftorafur and combination chemotherapy with mitomycin C and 5-fluorouracil for inoperable elderly gastric cancers].
    Nihon Gan Chiryo Gakkai shi, 1983, Feb-20, Volume: 18, Issue:1

    Topics: Aged; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Mitomycin; Mitomycins; Stomach Neoplasms; Tegafur

1983
[Clinical study related to the concentration of Futraful suppository in organs].
    Nihon Gan Chiryo Gakkai shi, 1983, Feb-20, Volume: 18, Issue:1

    Topics: Female; Fluorouracil; Humans; Jaw Neoplasms; Male; Mouth Neoplasms; Suppositories; Tegafur; Tissue Distribution

1983
[Preparation of trophic ulcers of the lower limbs for autodermoplasty].
    Sovetskaia meditsina, 1983, Issue:4

    Topics: Administration, Topical; Bandages; Fluorouracil; Humans; Preoperative Care; Skin Transplantation; Surgical Flaps; Tegafur; Varicose Ulcer

1983
[Evaluation of tissue concentrations of FT-207 and 5-FU in head and neck cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:4 Pt 1

    Topics: Adult; Aged; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Male; Middle Aged; Tegafur

1983
[Evaluation of chemotherapy of breast cancer (2). Clinical evaluation of the blood and tissue concentrations of FT-207 following intrarectal administration].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:4 Pt 1

    Topics: Breast; Breast Neoplasms; Female; Fluorouracil; Humans; Lymph Nodes; Suppositories; Tegafur

1983
[Combination chemotherapy of advanced gastric cancer with adriamycin, mitomycin C, and ftorafur].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:4 Pt 2

    Topics: Adenocarcinoma; Adult; Aged; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Middle Aged; Mitomycin; Mitomycins; Stomach Neoplasms; Tegafur

1983
[Case of Borrmann III stomach cancer effectively treated by UFT therapy (co-administration of uracil and futraful)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:4 Pt 2

    Topics: Adenocarcinoma; Administration, Oral; Aged; Drug Therapy, Combination; Fluorouracil; Humans; Male; Stomach Neoplasms; Tegafur

1983
[Conversion of 1-(2-tetrahydrofuryl-5-fluorouracil (FT-207) into 5-fluorouracil (5-FU) by human maxillary cancer cells (OKK) in culture].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:4 Pt 2

    Topics: Cells, Cultured; Fluorouracil; Humans; Maxillary Neoplasms; Tegafur

1983
[Effect of extended chemotherapy using tegafur following surgery of stage III stomach cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:6

    Topics: Aged; Drug Administration Schedule; Female; Fluorouracil; Humans; Lymphatic Metastasis; Male; Middle Aged; Postoperative Period; Stomach Neoplasms; Tegafur; Time Factors

1983
[Enzymatic conversion of tegafur in human tumor tissue].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:6

    Topics: Adult; Female; Fluorouracil; Humans; In Vitro Techniques; Liver Neoplasms; Middle Aged; Stomach Neoplasms; Tegafur; Thymidine Phosphorylase

1983
Metabolic activation of R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) to 5-fluorouracil by soluble enzymes.
    Cancer research, 1983, Volume: 43, Issue:9

    Topics: Animals; Biotransformation; Brain; Cytochrome P-450 Enzyme System; Cytosol; Fluorouracil; Intestine, Small; Kinetics; Liver; Male; Microsomes; Microsomes, Liver; Oxidation-Reduction; Rabbits; Tegafur

1983
[Chemotherapy of gastric cancer patients with hepatic metastases].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:2 Pt

    Topics: Administration, Oral; Antibiotics, Antineoplastic; Fluorouracil; Humans; Liver Neoplasms; Mitomycin; Mitomycins; Neoplasm Metastasis; Prognosis; Stomach Neoplasms; Suppositories; Tegafur

1983
[Effect of solcoseryl and combined therapy of solcoseryl and FT-207 for mice bearing meth-A tumor].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:2 Pt

    Topics: Actihaemyl; Animals; Drug Therapy, Combination; Fluorouracil; Methylcholanthrene; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; T-Lymphocytes; Tegafur; Tissue Extracts

1983
[Adjuvant chemotherapy for aged patients with gastric carcinoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:2 Pt

    Topics: Aged; Antineoplastic Agents; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Mitomycin; Mitomycins; Proteoglycans; Stomach Neoplasms; Tegafur

1983
[Study on the correlation between tissue uptake of anticancer agents and prognosis -- with special reference to Tegafur].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:8

    Topics: Adult; Aged; Antineoplastic Agents; Female; Fluorouracil; Humans; Lymph Nodes; Male; Middle Aged; Prognosis; Stomach Neoplasms; Tegafur

1983
[Level of 5-FU in tumor tissues of the patients with head and neck malignant tumors after oral administration of UFT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:8

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Fluorouracil; Head and Neck Neoplasms; Humans; Lymph Nodes; Tegafur; Uracil

1983
Effects of ftorafur and 5-fluorouracil on the canine sinoatrial node.
    Japanese journal of pharmacology, 1983, Volume: 33, Issue:2

    Topics: Aminophylline; Animals; Calcium; Dogs; Female; Fluorouracil; Heart Atria; Heart Rate; Male; Myocardial Contraction; Pindolol; Sinoatrial Node; Stimulation, Chemical; Tegafur; Verapamil

1983
Late results of postoperative long-term cancer chemotherapy for the gastric cancer patients subjected to curative resection.
    The Japanese journal of surgery, 1983, Volume: 13, Issue:2

    Topics: Antibiotics, Antineoplastic; Carcinoma; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Middle Aged; Mitomycin; Mitomycins; Neoplasm Staging; Postoperative Care; Proteoglycans; Stomach Neoplasms; Tegafur; Time Factors

1983
[Experience of a combination chemotherapy consisting of 5-FU, MMC, and FT-207--side effects against kidney].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:9

    Topics: Aged; Drug Therapy, Combination; Fluorouracil; Humans; Kidney Diseases; Male; Mitomycin; Mitomycins; Stomach Neoplasms; Tegafur

1983
Phase I evaluation of oral tegafur.
    Cancer treatment reports, 1983, Volume: 67, Issue:1

    Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Blood Cell Count; Diarrhea; Dose-Response Relationship, Drug; Drug Evaluation; Female; Fluorouracil; Humans; Liver Diseases; Male; Middle Aged; Nausea; Skin Diseases; Tegafur; Vomiting

1983
[UFT concentration in various tissues from cancer patients].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:10

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capsules; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Stomach Neoplasms; Tegafur; Tissue Distribution; Uracil

1983
[Analysis of factors affecting clinical cancer chemotherapy].
    Gan no rinsho. Japan journal of cancer clinics, 1983, Volume: 29, Issue:10

    Topics: Adenocarcinoma; Adult; Antineoplastic Agents; Breast Neoplasms; Drug Evaluation; Female; Fluorouracil; Humans; Lung Neoplasms; Male; Middle Aged; Mitomycin; Mitomycins; Pancreatic Neoplasms; Stomach Neoplasms; Tegafur

1983
Studies to increase the antitumor activity of 1-(tetrahydro-2-furanyl)-5-fluorouracil and its metabolic aspects by combined administration with L-cysteine.
    Japanese journal of pharmacology, 1983, Volume: 33, Issue:4

    Topics: Absorption; Animals; Antineoplastic Agents; Biotransformation; Cysteine; Fluorouracil; Kinetics; Lethal Dose 50; Male; Mice; Microsomes, Liver; Rats; Rats, Inbred Strains; Tegafur

1983
Simultaneous determination of tegafur and 5-fluorouracil in serum by GLC using nitrogen-sensitive detection.
    Journal of pharmaceutical sciences, 1983, Volume: 72, Issue:10

    Topics: Animals; Fluorouracil; Gas Chromatography-Mass Spectrometry; Injections, Intravenous; Kinetics; Male; Orotic Acid; Rabbits; Tegafur; Time Factors

1983
[Chemotherapy of unresectable Borrmann's type IV stomach cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Fluorouracil; Humans; Mitomycin; Mitomycins; Picibanil; Stomach Neoplasms; Tegafur

1983
[Clinical analysis on side effects of long-term oral administration of futraful to out-patients].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:12

    Topics: Administration, Oral; Alanine Transaminase; Aspartate Aminotransferases; Blood Proteins; Breast Neoplasms; Fluorouracil; Humans; L-Lactate Dehydrogenase; Outpatients; Serum Albumin; Stomach Neoplasms; Tegafur

1983
[Pharmacokinetics and a phase I study of tegafur-uracil enterogranules in cancer patients].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:12

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Delayed-Action Preparations; Drug Combinations; Drug Evaluation; Female; Fluorouracil; Humans; Kinetics; Male; Middle Aged; Nausea; Neoplasms; Tegafur; Uracil

1983
Duodenal adenoma with atypia following oral administration of tegafur.
    Archives of surgery (Chicago, Ill. : 1960), 1983, Volume: 118, Issue:12

    Topics: Adenoma; Duodenal Neoplasms; Fluorouracil; Humans; Male; Middle Aged; Postoperative Care; Stomach Neoplasms; Tegafur

1983
Enhancement of lymphatic transport of 1-(2-tetrahydrofuryl)-5-fluorouracil by polyacrylic acid aqueous gel and emulsion type suppositories in rats.
    Journal of pharmacobio-dynamics, 1983, Volume: 6, Issue:9

    Topics: Acrylic Resins; Animals; Biological Availability; Emulsions; Fluorouracil; Gels; Glycyrrhetinic Acid; Glycyrrhizic Acid; Hydrogen-Ion Concentration; Intestinal Absorption; Lymphatic System; Male; Rats; Rats, Inbred Strains; Suppositories; Tegafur

1983
[Experimental study of the efficacy of ftorafur phonophoresis in simulated allergic uveitis].
    Oftalmologicheskii zhurnal, 1983, Issue:7

    Topics: Animals; Chinchilla; Fluorouracil; Hypersensitivity; Tegafur; Ultrasonics; Uveitis

1983
[Kinetics and mechanism of ftorafur decomposition. 1. Determination of expiration dates of ftorafur injection solutions].
    Acta poloniae pharmaceutica, 1983, Volume: 40, Issue:3

    Topics: Drug Stability; Fluorouracil; Injections; Kinetics; Solutions; Tegafur; Time Factors

1983
[Adjuvant chemotherapy for gastric cancer--relation between long-term administration of FT-207 and prognosis].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:1

    Topics: Adult; Aged; Female; Fluorouracil; Humans; Male; Middle Aged; Prognosis; Stomach Neoplasms; Tegafur

1984
[Preoperative treatment of FT-207 suppository in cervical cancer-- serum and tumor tissue content of FT-207].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:2

    Topics: Cervix Uteri; Female; Fluorouracil; Humans; Suppositories; Tegafur; Uterine Cervical Neoplasms

1984
[Cooperative phase II study of spansule tegafur (SF-SP)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:2

    Topics: Administration, Oral; Aged; Breast Neoplasms; Capsules; Colonic Neoplasms; Delayed-Action Preparations; Drug Evaluation; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Rectal Neoplasms; Stomach Neoplasms; Tegafur

1984
[Long-term maintenance chemotherapy for pseudomyxoma peritonei of ovarian origin].
    Nihon Sanka Fujinka Gakkai zasshi, 1984, Volume: 36, Issue:1

    Topics: Aged; Cyclophosphamide; Female; Fluorouracil; Humans; Hysterectomy; Middle Aged; Neoplasm Seeding; Ovarian Neoplasms; Peritoneal Neoplasms; Reoperation; Tegafur

1984
Phase I-II studies of oral tegafur (ftorafur).
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1983, Volume: 1, Issue:2

    Topics: Administration, Oral; Bone Marrow; Breast Neoplasms; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Evaluation; Fluorouracil; Humans; Leukopenia; Nausea; Neoplasms; Rectal Neoplasms; Tegafur; Vomiting

1983
[Effective cases of advanced endometrial and recurrent ovarian cancers treated with oral administration of UFT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:3

    Topics: Adenocarcinoma; Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Drug Combinations; Female; Fluorouracil; Humans; Lymphatic Metastasis; Middle Aged; Neoplasm Recurrence, Local; Ovarian Neoplasms; Tegafur; Uracil; Uterine Neoplasms

1984
Plasma levels of tegafur following implantation of polycarbonate pellets containing tegafur or FD-1 into rats.
    Chemical & pharmaceutical bulletin, 1983, Volume: 31, Issue:11

    Topics: Animals; Drug Implants; Fluorouracil; Male; Rats; Rats, Inbred Strains; Tegafur

1983
[Clinical studies of kallidinogenase in combined chemotherapy for cervical cancer].
    Nihon Gan Chiryo Gakkai shi, 1983, Oct-20, Volume: 18, Issue:7

    Topics: Drug Synergism; Drug Therapy, Combination; Female; Fluorouracil; Humans; Kallikreins; Tegafur; Uterine Cervical Neoplasms

1983
Effect of coadministration of uracil on the toxicity of tegafur.
    Journal of pharmaceutical sciences, 1984, Volume: 73, Issue:2

    Topics: Animals; beta-Alanine; Cats; Dogs; Female; Fluorouracil; Heart Diseases; Lethal Dose 50; Male; Mice; Nervous System Diseases; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Tegafur; Uracil

1984
Phase II study of orally and rectally administered Tegafur in liver metastases from gastric carcinoma.
    Japanese journal of clinical oncology, 1984, Volume: 14, Issue:1

    Topics: Administration, Oral; Adult; Aged; Drug Evaluation; Female; Fluorouracil; Humans; Liver Neoplasms; Male; Middle Aged; Rectum; Stomach Neoplasms; Tegafur; Thrombocytopenia

1984
Prophylactic long-term treatment of bladder tumors with oral chemotherapy (tegafur).
    Urology, 1984, Volume: 23, Issue:4

    Topics: Actuarial Analysis; Administration, Oral; Adult; Aged; Combined Modality Therapy; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Tegafur; Time Factors; Urinary Bladder Neoplasms

1984
[Chemical modification of anticancer agents from viewpoints of their pharmacokinetics].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:3 Pt 2

    Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Cytarabine; Doxorubicin; Fibrosarcoma; Fluorouracil; Kinetics; Mice; Mitomycin; Mitomycins; Rabbits; Sarcoma, Experimental; Tegafur

1984
[Regulation of enzyme activities involved in pyrimidine synthesis and its application to cancer chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:3 Pt 2

    Topics: Administration, Oral; Animals; Deoxyuridine; Dihydrouracil Dehydrogenase (NAD+); DNA, Neoplasm; Drug Synergism; Fluorouracil; Neoplasms, Experimental; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pentosyltransferases; Phosphorylation; Pyrimidines; Sarcoma, Yoshida; Tegafur; Thymidine; Thymine; Uracil; Uridine

1984
[Clinical application of tegafur suppositories for bladder tumor].
    Hinyokika kiyo. Acta urologica Japonica, 1983, Volume: 29, Issue:8

    Topics: Adult; Aged; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Fluorouracil; Humans; Male; Middle Aged; Papilloma; Suppositories; Tegafur; Urinary Bladder Neoplasms

1983
Blepharospasm associated with tegafur combination chemotherapy.
    American journal of ophthalmology, 1984, Volume: 97, Issue:5

    Topics: Antineoplastic Agents; Blepharospasm; Drug Therapy, Combination; Eyelid Diseases; Female; Fluorouracil; Humans; Middle Aged; Tegafur

1984
[Pharmacokinetics of FT-207 rectum suppository in squamous cell carcinoma of the uterine cervix. (I) Pharmacokinetics in single administration at a dose of 1 gram].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:4

    Topics: Carcinoma, Squamous Cell; Female; Fluorouracil; Humans; Kinetics; Rectum; Suppositories; Tegafur; Uterine Cervical Neoplasms; Uterus

1984
[Pharmacokinetics of FT-207 rectum suppository in squamous cell carcinoma of the uterine cervix. (II) Pharmacokinetics in continuous administration at a daily dose of 1 gram].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:4

    Topics: Carcinoma, Squamous Cell; Drug Administration Schedule; Female; Fluorouracil; Humans; Kinetics; Lymph Nodes; Rectum; Suppositories; Tegafur; Uterine Cervical Neoplasms; Uterus

1984
[Intraperitoneal administration of FT-207 for mouse peritonitis carcinomatosa].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:4

    Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Division; Fluorouracil; Injections, Intraperitoneal; Macrophages; Mice; Microscopy, Electron, Scanning; Peritonitis; Tegafur

1984
[FT-207 and 5-FU concentrations in brain tumor tissues, plasma and CSF after administration of FT-207 suppository].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:4

    Topics: Brain; Brain Neoplasms; Fluorouracil; Humans; Rectum; Suppositories; Tegafur

1984
[Studies on the mechanism of antitumor activity of 5-FU and its derivatives--relationship between the inhibition of tumor growth and the inhibition of thymidylate synthetase in vivo].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:5

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Division; DNA, Neoplasm; Drug Combinations; Fluorouracil; Male; Methyltransferases; Mice; Sarcoma 180; Tegafur; Thymidylate Synthase; Uracil

1984
[The case studies on oral administration of tegafur encapsulated with slow releasing granule (SF-SP) for three rectal patients].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:5

    Topics: Adenocarcinoma; Administration, Oral; Aged; Capsules; Delayed-Action Preparations; Female; Fluorouracil; Humans; Male; Middle Aged; Rectal Neoplasms; Tegafur

1984
[Effects of long-term administration of Tegafur on patients with relapsing advanced carcinoma (stage D) of the prostate].
    Hinyokika kiyo. Acta urologica Japonica, 1983, Volume: 29, Issue:1

    Topics: Aged; Estrogens; Fluorouracil; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Prostatic Neoplasms; Tegafur

1983
[Combination chemotherapy of CIS-diamminedichloroplatinum (II) and fluoropyrimidine derivatives for advanced gastric cancer: a preliminary report].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:6

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Fluorouracil; Humans; Male; Middle Aged; Stomach Neoplasms; Tegafur

1984
Combination of hepatic arterial infusion and systemic chemotherapy for gastric cancer with synchronous hepatic metastases.
    The Japanese journal of surgery, 1984, Volume: 14, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Mitomycin; Mitomycins; Prognosis; Proteoglycans; Stomach Neoplasms; Tegafur

1984
[Pharmacological compatibility of the antineoplastic drugs ftorafur and 5-fluorouracil with the psychotropic drugs aminazine and phenazepam (an experimental study)].
    Vestnik Akademii meditsinskikh nauk SSSR, 1984, Issue:5

    Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Chlorpromazine; Drug Interactions; Fluorouracil; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Neoplasms, Experimental; Rats; Tegafur

1984
[Cooperative phase II study of releasing tegafur (SF-SP) against advanced digestive cancers].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:7

    Topics: Administration, Oral; Adult; Aged; Colonic Neoplasms; Delayed-Action Preparations; Digestive System Neoplasms; Drug Evaluation; Esophageal Neoplasms; Female; Fluorouracil; Humans; Male; Middle Aged; Pancreatic Neoplasms; Stomach Neoplasms; Tegafur

1984
[Chemotherapy of unresectable Borrmann type 4 gastric cancer].
    Gan no rinsho. Japan journal of cancer clinics, 1984, Volume: 30, Issue:6 Suppl

    Topics: Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Drug Combinations; Fluorouracil; Humans; Mitomycin; Mitomycins; Nimustine; Nitrosourea Compounds; Picibanil; Proteoglycans; Stomach Neoplasms; Tegafur; Uracil

1984
Combination chemoimmunotherapy for advanced gastric carcinoma.
    The Japanese journal of surgery, 1984, Volume: 14, Issue:3

    Topics: Adjuvants, Immunologic; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Carcinoma; Combined Modality Therapy; Cyclophosphamide; Female; Fluorouracil; Humans; Immunotherapy; Male; Middle Aged; Mitomycin; Mitomycins; Stomach Neoplasms; Tegafur

1984
[Experimental chemotherapy of human gastrointestinal and breast cancers in nude mice and its correlation to clinical effect].
    Gan no rinsho. Japan journal of cancer clinics, 1984, Volume: 30, Issue:9 Suppl

    Topics: Adenocarcinoma; Adult; Aged; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Colonic Neoplasms; Cyclophosphamide; Drug Combinations; Female; Fluorouracil; Humans; Male; Mice; Mice, Nude; Middle Aged; Neoplasm Transplantation; Rectal Neoplasms; Stomach Neoplasms; Tegafur; Uracil

1984
Neuropathologic study on chronic neurotoxicity of 5-fluorouracil and its masked compounds in dogs.
    Acta neuropathologica, 1984, Volume: 63, Issue:4

    Topics: Animals; Axons; Brain; Dogs; Female; Fluorouracil; Male; Microscopy, Electron; Myelin Sheath; Neuroglia; Neurons; Tegafur; Vacuoles

1984
[Study on the concentration of FT-207 and 5-FU in serum, lymph nodes and tissues after administration of FT-207 suppositories].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:8

    Topics: Adult; Aged; Breast Neoplasms; Female; Fluorouracil; Humans; Lymph Nodes; Lymphoma, Non-Hodgkin; Male; Middle Aged; Rectal Neoplasms; Stomach Neoplasms; Suppositories; Tegafur

1984
[Thermotherapy for cancer of the urinary bladder in combination with tegafur and picibanil--with special reference to the serum bladder and bladder cancer tissue concentrations of tegafur in a perfusion fluid].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:9

    Topics: Aged; Biological Products; Combined Modality Therapy; Drug Therapy, Combination; Female; Fluorouracil; Humans; Hyperthermia, Induced; Male; Middle Aged; Picibanil; Tegafur; Urinary Bladder; Urinary Bladder Neoplasms

1984
[Influence of PSK on the metabolism of FT-207].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:9

    Topics: Antibiotics, Antineoplastic; Fluorouracil; Humans; Proteoglycans; Stomach Neoplasms; Tegafur

1984
[Antitumor effect of FU-O-G, new antitumor agent, following long term administration].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:9

    Topics: Animals; Antineoplastic Agents; Carbazilquinone; Drug Administration Schedule; Drug Synergism; Female; Fluorouracil; Liver Neoplasms, Experimental; Lung Neoplasms; Mice; Neoplasm Transplantation; Nimustine; Nitrosourea Compounds; Pyrimidine Nucleosides; Tegafur

1984
Enhanced accumulation of 5-fluorouracil in human tumors in athymic mice by co-administration of Ftorafur and uracil.
    International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9

    Topics: Animals; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Tegafur; Time Factors; Transplantation, Heterologous; Uracil

1984
[Maximum tolerated dose of tegafur in rats].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:10

    Topics: Administration, Oral; Animals; Body Weight; Drug Administration Schedule; Drug Tolerance; Fluorouracil; Kidney; Liver; Lung; Male; Necrosis; Organ Size; Rats; Rats, Inbred Strains; Tegafur

1984
[Pharmacokinetics of vaginal suppository FT-207 in uterine cervical cancer and radiation therapy].
    Nihon Gan Chiryo Gakkai shi, 1984, May-20, Volume: 19, Issue:4

    Topics: Combined Modality Therapy; Female; Fluorouracil; Humans; Kinetics; Middle Aged; Suppositories; Tegafur; Uterine Cervical Neoplasms

1984
[Pharmacokinetics of fluoropyrimidines].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:11

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Ehrlich Tumor; Fluorouracil; Humans; Infusions, Parenteral; Kinetics; Mice; Neoplasms; Rabbits; Tegafur; Uracil

1984
[Fluorinated pyrimidines--administration methods].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:11

    Topics: Drug Administration Schedule; Fluorouracil; Humans; Infusions, Parenteral; Neoplasms; Tegafur

1984
[Comparative pharmacokinetic study between UFT and FT-207 suppo and phase II studies in gynecological malignancies].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:11

    Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; Female; Fluorouracil; Humans; Kinetics; Middle Aged; Tegafur; Uracil; Uterine Cervical Neoplasms; Uterine Neoplasms

1984
[10 years' use of ftorafur in tumor chemotherapy at the Robert Rössle Institute. A retrospective analysis from the clinical-toxologic point of view].
    Archiv fur Geschwulstforschung, 1984, Volume: 54, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Fluorouracil; Humans; Lomustine; Male; Methotrexate; Middle Aged; Neoplasms; Retrospective Studies; Tamoxifen; Tegafur; Vinblastine; Vincristine

1984
Fluorescence determination of 5-fluorouracil and 1-(tetrahydro-2-furanyl)-5-fluorouracil in blood serum by high-performance liquid chromatography.
    Journal of chromatography, 1984, Sep-14, Volume: 310, Issue:1

    Topics: Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Fluorouracil; Humans; Spectrometry, Fluorescence; Tegafur; Time Factors

1984
Cytochrome P-450-dependent oxidative cleavage of 1-(tetrahydro-2-furanyl)-5-fluorouracil to 5-fluorouracil.
    Japanese journal of pharmacology, 1984, Volume: 36, Issue:1

    Topics: Animals; Cytochrome P-450 Enzyme System; Fluorouracil; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Oxidation-Reduction; Rabbits; Tegafur

1984
[Chemotherapy of renal cell carcinoma. 3. Single-agent therapy with FT-207 or vinblastine].
    Nihon Hinyokika Gakkai zasshi. The japanese journal of urology, 1984, Volume: 75, Issue:6

    Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Carcinoma, Renal Cell; Female; Fluorouracil; Humans; Injections, Intravenous; Kidney Neoplasms; Male; Middle Aged; Neoplasm Staging; Tegafur; Vinblastine

1984
[Evaluation of tegafur encapsulated with slow-releasing granules (SF-SP) for patients with cancer of the digestive organs].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:12 Pt 1

    Topics: Administration, Oral; Adult; Aged; Capsules; Colonic Neoplasms; Delayed-Action Preparations; Drug Evaluation; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Liver Neoplasms; Male; Middle Aged; Pancreatic Neoplasms; Stomach Neoplasms; Tegafur

1984
[Adjuvant chemotherapy after surgery in advanced gastric cancer].
    Gan no rinsho. Japan journal of cancer clinics, 1984, Volume: 30, Issue:14

    Topics: Administration, Oral; Adult; Aged; Analysis of Variance; Drug Administration Schedule; Fluorouracil; Gastrectomy; Humans; Middle Aged; Postoperative Care; Stomach Neoplasms; Tegafur

1984
[Postoperative adjuvant chemotherapy with N1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) for gastric cancer patients. Influence of fat emulsification on lymphatic transport].
    Nihon Gan Chiryo Gakkai shi, 1984, Aug-20, Volume: 19, Issue:7

    Topics: Adult; Aged; Fat Emulsions, Intravenous; Fluorouracil; Humans; Lymphatic System; Male; Middle Aged; Postoperative Period; Stomach Neoplasms; Tegafur

1984
Enhancement of lymphatic transport of N1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) by water-in-oil emulsion in postoperative adjuvant chemotherapy for gastric cancer.
    The Keio journal of medicine, 1984, Volume: 33, Issue:4

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Emulsions; Fluorouracil; Humans; Male; Middle Aged; Oils; Stomach Neoplasms; Tablets, Enteric-Coated; Tegafur

1984
Photosensitivity from oral administration of a fluorouracil derivative (FT 207).
    Photo-dermatology, 1984, Volume: 1, Issue:2

    Topics: Aged; Antimetabolites, Antineoplastic; Fluorouracil; Humans; Male; Photosensitivity Disorders; Tegafur

1984
Role of uridine phosphorylase for antitumor activity of 5'-deoxy-5-fluorouridine.
    Gan, 1980, Volume: 71, Issue:1

    Topics: Animals; Biotransformation; Floxuridine; Fluorouracil; Leukemia L1210; Male; Mice; Pentosyltransferases; Sarcoma 180; Tegafur; Thymidine; Uridine; Uridine Phosphorylase

1980
[Chemotherapy of pancreatic cancer is not yet generally recommended].
    Medizinische Klinik, 1980, Aug-01, Volume: 75, Issue:16

    Topics: Antineoplastic Agents; Carmustine; Cyclophosphamide; Doxorubicin; Drug Evaluation; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Mitomycins; Pancreatic Neoplasms; Streptozocin; Tegafur

1980
Comparative studies on the immunosuppressive effect among 5'-deoxy-5-fluorouridine, ftorafur, and 5-fluorouracil.
    Gan, 1980, Volume: 71, Issue:2

    Topics: Animals; Antibody Formation; Erythrocytes; Female; Floxuridine; Fluorouracil; Graft Rejection; Hypersensitivity, Delayed; Immunity, Cellular; Immunosuppressive Agents; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Tegafur

1980
Tissue distribution of 5'-deoxy-5-fluorouridine and derived 5-fluorouracil in tumor-bearing mice and rats.
    Gan, 1980, Volume: 71, Issue:2

    Topics: Animals; Carcinoma 256, Walker; Female; Floxuridine; Fluorouracil; Male; Mice; Rats; Sarcoma 180; Tegafur; Tissue Distribution

1980
Differential effects of 5-fluorouracil analogs on humoral and cell-mediated responses in mice: augmentation of delayed hypersensitivity response against picryl chloride by 1,3-bis(tetrahydro-2-furanyl)-5-fluoro-2,4-pyrimidinedione (FD-1), a new anti-tumor
    Journal of clinical & laboratory immunology, 1980, Volume: 4, Issue:3

    Topics: Animals; Antibody Formation; Drug Hypersensitivity; Fluorouracil; Graft Rejection; Hypersensitivity, Delayed; Immune Tolerance; Male; Mice; Picryl Chloride; Skin Transplantation; T-Lymphocytes, Regulatory; Tegafur; Transplantation, Homologous

1980
Review of a new antimetabolic agent, 1,3-bis(tetrahydro-2-furanyl)-5-fluoro-2,4-pyrimidinedione (FD-1).
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1980, Volume: 70

    Topics: Adult; Aged; Animals; Antimetabolites, Antineoplastic; Delayed-Action Preparations; Dogs; Drug Evaluation; Drug Evaluation, Preclinical; Female; Fluorouracil; Humans; Male; Mice; Middle Aged; Neoplasms; Neoplasms, Experimental; Rats; Tegafur; Vomiting

1980
[Surgical method and combination chemotherapy in treating stage-III and IV ovarian cancer].
    Voprosy onkologii, 1980, Volume: 26, Issue:2

    Topics: Altretamine; Antineoplastic Agents; Carcinoma; Cyclophosphamide; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Fluorouracil; Humans; Methotrexate; Ovarian Neoplasms; Ovary; Postoperative Care; Tegafur; Time Factors

1980
Therapeutic effect dependent on timing of combination treatment with chemotherapy and allogeneic lymphoid cell transfer in rats.
    Transplantation proceedings, 1980, Volume: 12, Issue:1

    Topics: Animals; Cell Transformation, Neoplastic; Cyclophosphamide; Drug Therapy, Combination; Fibrosarcoma; Fluorouracil; Immunization, Passive; Lymphocyte Transfusion; Rats; Rats, Inbred Strains; Tegafur; Time Factors; Transplantation, Homologous

1980
Structure of two hydroxylated metabolites of ftorafur.
    Biochemical pharmacology, 1980, Feb-15, Volume: 29, Issue:4

    Topics: Chemical Phenomena; Chemistry, Physical; Fluorouracil; Hydroxylation; Stereoisomerism; Tegafur

1980
Intensified cancer themotherapy by induction of hepatic drug-metabolizing enzymes as a trial for the treatment for stomach cancer.
    The Japanese journal of surgery, 1980, Volume: 10, Issue:1

    Topics: Drug Therapy, Combination; Enzyme Induction; Fluorouracil; Humans; Liver; Mitomycins; Phenobarbital; Stomach Neoplasms; Tegafur

1980
Effect of coadministration of thymine or thymidine on the antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil.
    Gan, 1980, Volume: 71, Issue:1

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Biodegradation, Environmental; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Liver; Male; Mice; Phosphorylation; Rats; Sarcoma 180; Sarcoma, Yoshida; Tegafur; Thymidine; Thymidine Phosphorylase; Thymine; Uracil; Uridine; Uridine Phosphorylase

1980
Metabolism, antitumor activity, and acute toxicity of 5-fluoro-1,3-bis(tetrahydro-2-furanyl)-2,4-pyrimidinedione by oral administration to animals.
    Gan, 1980, Volume: 71, Issue:1

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Biotransformation; Chemical Phenomena; Chemistry; Fluorouracil; In Vitro Techniques; Male; Mass Spectrometry; Microsomes, Liver; Rats; Tegafur; Tissue Distribution

1980
Quantitative determination of 1,3-bis(tetrahydro-2-furanyl)-5-fluoro-2,4-pyrimidinedione and its metabolites in visceral tissues by high-performance liquid chromatography and gas chromatography-mass fragmentography.
    Journal of chromatography, 1980, Jan-25, Volume: 188, Issue:1

    Topics: Animals; Chromatography, High Pressure Liquid; Fluorouracil; Gas Chromatography-Mass Spectrometry; Neoplasms; Rats; Tegafur

1980
[Combined chemoimmunotherapy in stomach cancer and hematosarcoma].
    Voprosy onkologii, 1980, Volume: 26, Issue:5

    Topics: Cyclophosphamide; Drug Therapy, Combination; Fluorouracil; Hemangiosarcoma; Humans; Immunotherapy; Neoplasm Recurrence, Local; Stomach Neoplasms; Tegafur; Time Factors

1980
Activation of Ftorafue [R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil] to 5-fluorouracil and gamma-butyrolactone.
    Cancer research, 1980, Volume: 40, Issue:8 Pt 1

    Topics: 4-Butyrolactone; Animals; Biotransformation; Cell-Free System; Chromatography, Gas; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Fluorouracil; Furans; Humans; Male; Metabolic Clearance Rate; Mice; Microsomes, Liver; Rabbits; Tegafur

1980
[Drug exanthema caused by a new 5-fluorouracil derivative].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1980, Volume: 31, Issue:4

    Topics: Chemical Phenomena; Chemistry; Exanthema; Female; Fluorouracil; Humans; Middle Aged; Tegafur

1980
Identification of metabolites of 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT-207) formed in vitro by rat liver microsomes.
    Chemical & pharmaceutical bulletin, 1980, Volume: 28, Issue:6

    Topics: Animals; Fluorouracil; In Vitro Techniques; Male; Microsomes, Liver; Rats; Tegafur

1980
Clinical basis of chemotherapy for gastric cancer with uracil and 1-(2'-tetrahydrofuryl)-5-fluorouracil.
    Gastroenterologia Japonica, 1980, Volume: 15, Issue:4

    Topics: Female; Fluorouracil; Humans; In Vitro Techniques; Stomach Neoplasms; Tegafur; Time Factors; Uracil

1980
[Studies in vivo and in vitro on the influence of 5-fluorouracil and n'-(2'-furanidyl)-5-fluorouracil on the walker carcinosarcoma 256 in the rat (author's transl)].
    Arzneimittel-Forschung, 1980, Volume: 30, Issue:6

    Topics: Animals; Carcinoma 256, Walker; Deoxyuridine; Dose-Response Relationship, Drug; Fluorouracil; Male; Rats; Tegafur

1980
Relationship of chemotherapy on human cancer xenografts in nude mice to clinical response in donor patient.
    Journal of surgical oncology, 1980, Volume: 15, Issue:3

    Topics: Adult; Animals; Cytarabine; Drug Resistance; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Mice; Mice, Nude; Middle Aged; Mitomycins; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; Tegafur; Transplantation, Heterologous

1980
Altered pharmacodynamics of 1-(2-tetrahydrofuryl)-5-fluorouracil by pretreatment of rats with phenobarbital, indomethacin, diclofenac sodium and carbon tetrachloride.
    Pharmacology, 1980, Volume: 21, Issue:5

    Topics: Animals; Carbon Tetrachloride; Diclofenac; Female; Fluorouracil; Indomethacin; Microsomes, Liver; Phenobarbital; Phenylacetates; Rats; Tegafur; Time Factors

1980
Chemoprevention of development of colonic adenomatosis and carcinomatosis with 5-fluorouracil and ftorafur on animal model.
    Journal of cancer research and clinical oncology, 1980, Volume: 97, Issue:3

    Topics: Adenoma; Animals; Carcinoma; Colon; Colonic Neoplasms; Female; Fluorouracil; Methylnitrosourea; Neoplasms, Experimental; Rats; Tegafur

1980
Effects on 1,3-bis(tetrahydro-2-furanyl)-5-fluoro-2,4-pyrimidinedione(FD-1) on the central nervous system: 1. Effects on monoamines in the brain.
    Archives internationales de pharmacodynamie et de therapie, 1980, Volume: 247, Issue:2

    Topics: Acetylcholine; Animals; Antineoplastic Agents; Biogenic Amines; Brain Chemistry; Corpus Striatum; Fluorouracil; Hydroxybutyrates; Male; Rats; Tegafur; Time Factors

1980
[Induced chromosome aberrations in multiple primary neoplasms].
    Genetika, 1980, Volume: 16, Issue:7

    Topics: Adult; Chromosome Aberrations; Female; Fluorouracil; Humans; In Vitro Techniques; Lymphocytes; Male; Middle Aged; Neoplasms, Multiple Primary; Tegafur

1980
High-pressure liquid chromatographic determination of ftorafur [1-(tetrahydro-2-furanyl)-5-fluorouracil] and GLC-mass spectrometric determination of 5-fluorouracil and uracil in biological materials after oral administration of uracil plus ftorafur.
    Journal of pharmaceutical sciences, 1980, Volume: 69, Issue:11

    Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Fluorouracil; Gas Chromatography-Mass Spectrometry; Male; Neoplasms, Experimental; Rats; Tegafur; Uracil

1980
Effect of normal allogeneic lymphoid cell transfer in combination with chemotherapy on a transplantable tumor in rats.
    Cancer research, 1980, Volume: 40, Issue:3

    Topics: Animals; Cyclophosphamide; Drug Therapy, Combination; Fibrosarcoma; Fluorouracil; Immunotherapy; Lymphocyte Transfusion; Rats; Sarcoma, Experimental; Tegafur; Time Factors; Transplantation, Homologous

1980
A review of the United States clinical experience of the fluoropyrimidine, ftorafur (NSC-148958).
    Cancer treatment reviews, 1980, Volume: 7, Issue:4

    Topics: Administration, Oral; Dose-Response Relationship, Drug; Drug Evaluation; Drug Therapy, Combination; Fluorouracil; Humans; Injections, Intravenous; Neoplasms; Tegafur

1980
Determination of 5-fluorouracil and pyrimidine bases in plasma by gas chromatography-chemical ionization-mass fragmentography.
    Journal of chromatography, 1980, Dec-12, Volume: 221, Issue:2

    Topics: Cytosine; Fluorouracil; Gas Chromatography-Mass Spectrometry; Humans; Ions; Pyrimidines; Tegafur; Thymine; Uracil

1980
Comparing cell kinetic studies of the effect of ftorafur and 5-fluorouracil on the L 1210 ascites tumor.
    Journal of cancer research and clinical oncology, 1981, Volume: 100, Issue:1

    Topics: Animals; Cell Division; Female; Fluorouracil; Kinetics; Leukemia L1210; Mice; Mitosis; Neoplasm Transplantation; Tegafur; Thymidine; Transplantation, Homologous; Uridine

1981
Clastogenic effects of ftorafur. II. Cytogenetic analyses of bone marrow in mice.
    Mutation research, 1981, Volume: 88, Issue:3

    Topics: Animals; Bone Marrow; Carcinogens; Chromosome Aberrations; Chromosomes; Dose-Response Relationship, Drug; Fluorouracil; Mice; Mice, Inbred C57BL; Mutagens; Tegafur; Time Factors

1981
Toxicologic and therapeutic examinations with ftorafur in different mouse strains.
    Neoplasma, 1981, Volume: 28, Issue:2

    Topics: Animals; Female; Fluorouracil; Male; Mice; Mice, Nude; Neoplasms, Experimental; Sex Factors; Tegafur

1981
[Chemo-endocrine therapy for advanced breast cancer--a combined treatment with tamoxifen and FT 207-- (author's transl)].
    Nihon Gan Chiryo Gakkai shi, 1981, Feb-20, Volume: 16, Issue:1

    Topics: Breast Neoplasms; Drug Therapy, Combination; Female; Fluorouracil; Humans; Tamoxifen; Tegafur

1981
[ACF combination consisting of adriamycin, cyclophosphamide and oral futraful for recurrent advanced breast cancer (author's transl)].
    Nihon Gan Chiryo Gakkai shi, 1981, Feb-20, Volume: 16, Issue:1

    Topics: Adult; Aged; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Middle Aged; Neoplasm Recurrence, Local; Tegafur

1981
[Educational lecture of cancer chemotherapy: with references to stomach cancer (author's transl)].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1981, Volume: 70, Issue:3

    Topics: Antineoplastic Agents; Drug Therapy, Combination; Fluorouracil; Humans; Stomach Neoplasms; Tegafur

1981
Studies on the metabolism of 1-(2-tetrahydrofuryl)-5-fluorouracil and uracil co-administered orally to tumor-bearing rats.
    Gan, 1980, Volume: 71, Issue:6

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Drug Combinations; Fluorouracil; Intestinal Absorption; Neoplasms, Experimental; Rats; Tegafur; Uracil

1980
Comparative efficacy of antitumor treatment for liver metastases from colorectal cancer.
    The Japanese journal of surgery, 1981, Volume: 11, Issue:3

    Topics: Adult; Aged; Antineoplastic Agents; Colonic Neoplasms; Female; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Rectal Neoplasms; Retrospective Studies; Tegafur

1981
Antitumor activity of methyl (5-fluoro-1H-2-oxo-4-pyrimidinyl beta-D-glucopyranosid)uronate against various experimental tumors.
    Gan, 1981, Volume: 72, Issue:2

    Topics: Animals; Antineoplastic Agents; Carcinoma; Carcinoma 256, Walker; Female; Fluorouracil; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Pyrimidine Nucleosides; Rats; Tegafur; Time Factors

1981
Clastogenicity and sister chromatid exchange induction by ftorafur.
    Neoplasma, 1981, Volume: 28, Issue:4

    Topics: Animals; Burkitt Lymphoma; Cell Line; Chromosomes; Chromosomes, Human; Cricetinae; Crossing Over, Genetic; Culture Techniques; Fibroblasts; Fluorouracil; Humans; Lymphocytes; Mammary Neoplasms, Experimental; Melanoma; Mutagens; Sister Chromatid Exchange; Tegafur

1981
General pharmacological properties of UFT, a new type of anti-cancer agent consisting of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT) and uracil. I: Pharmacological analysis of the combined effect of FT and uracil.
    Arzneimittel-Forschung, 1981, Volume: 31, Issue:8

    Topics: Analgesics; Animals; Anticonvulsants; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Behavior, Animal; Body Temperature; Brain Chemistry; Digestive System; Dogs; Drug Combinations; Electroencephalography; Female; Fluorouracil; Guinea Pigs; Hemodynamics; Male; Mice; Postural Balance; Rabbits; Rats; Respiration; Tegafur; Uracil

1981
Enzymatic formation of 5-fluorouracil from 1-(tetrahydro-2-furanyl)- 5-fluorouracil (tegafur) in human tumor tissues.
    Chemical & pharmaceutical bulletin, 1981, Volume: 29, Issue:5

    Topics: Biotransformation; Fluorouracil; Humans; In Vitro Techniques; Lung Neoplasms; Tegafur

1981
Improved liquid chromatographic assay for serum fluorouracil concentrations in the presence of ftorafur.
    Journal of pharmaceutical sciences, 1981, Volume: 70, Issue:10

    Topics: Chromatography, Liquid; Drug Stability; Drug Storage; Fluorouracil; Gastrointestinal Neoplasms; Humans; Tegafur

1981
High-dose therapy with ftorafur in gastrointestinal cancer.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1981, Volume: 79

    Topics: Animals; Carcinoma, Ehrlich Tumor; Drug Therapy, Combination; Fluorouracil; Gastrointestinal Neoplasms; Male; Mice; Neoplasm Metastasis; Tegafur

1981
Changes in toxic and antitumor properties of ftorafur by induction or inhibition of the microsomal enzymes activity.
    Cancer chemotherapy and pharmacology, 1981, Volume: 6, Issue:2

    Topics: Animals; Antineoplastic Agents; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Female; Fluorouracil; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; Phenobarbital; Tegafur

1981
Correlation between the level of urinary D-glucaric acid and the degree of activation of masked compound (FT-207) in cancer patients.
    The Tohoku journal of experimental medicine, 1981, Volume: 135, Issue:3

    Topics: Adult; Aged; Biotransformation; Cytochrome P-450 Enzyme System; Esophageal Neoplasms; Female; Fluorouracil; Glucaric Acid; Humans; Kinetics; Male; Microsomes, Liver; Middle Aged; Neoplasms; Pancreatic Neoplasms; Stomach Neoplasms; Sugar Acids; Tegafur

1981
[A case of inoperable esophageal carcinoma responding to adriamycin and FT 207 suppository for more than one year (author's transl)].
    Nihon Gan Chiryo Gakkai shi, 1981, Jun-20, Volume: 16, Issue:3

    Topics: Aged; Carcinoma, Squamous Cell; Doxorubicin; Drug Therapy, Combination; Esophageal Neoplasms; Female; Fluorouracil; Humans; Suppositories; Tegafur

1981
[Conservative treatment of primary and recurrent malignant stomach neoplasms].
    Vestnik Akademii meditsinskikh nauk SSSR, 1981, Issue:11

    Topics: Adenocarcinoma; Adult; Aged; Carcinoma; Carcinoma, Squamous Cell; Female; Fluorouracil; Humans; Male; Middle Aged; Radioisotope Teletherapy; Radiotherapy Dosage; Stomach Neoplasms; Tegafur

1981
[Long-term chemotherapy with FT-207 for ovarian cancer (author's transl)].
    Nihon Gan Chiryo Gakkai shi, 1981, Aug-20, Volume: 16, Issue:4

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Drug Administration Schedule; Female; Fluorouracil; Humans; Middle Aged; Ovarian Neoplasms; Tegafur; Time Factors

1981
FQC combination chemotherapy for primary malignant ovarian tumor.
    Gynecologic oncology, 1982, Volume: 13, Issue:1

    Topics: Azirines; Carbazilquinone; Cytarabine; Drug Therapy, Combination; Female; Fluorouracil; Humans; Ovarian Neoplasms; Tegafur

1982
Stereoselective metabolism of ftorafur (R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil).
    Cancer chemotherapy and pharmacology, 1981, Volume: 7, Issue:1

    Topics: Animals; Biotransformation; Chromatography, Gas; Chromatography, High Pressure Liquid; Female; Fluorouracil; Hydroxylation; Liver; Mice; Microsomes, Liver; Rabbits; Rats; Rats, Inbred Strains; Stereoisomerism; Tegafur; Thymidine Phosphorylase

1981
[Effects of UFT administered preoperatively in cases of gastric cancer (author's transl)].
    Nihon Gan Chiryo Gakkai shi, 1981, Dec-20, Volume: 16, Issue:7

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Preoperative Care; Stomach Neoplasms; Tegafur; Uracil

1981
Loss of tRNA 5-methyluridine methyltransferase and pseudouridine synthetase activities in 5-fluorouracil and 1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur)-treated Escherichia coli.
    Biochimica et biophysica acta, 1982, Apr-26, Volume: 697, Issue:1

    Topics: Escherichia coli; Fluorouracil; Intramolecular Transferases; Kinetics; Pseudouridine; Tegafur; tRNA Methyltransferases

1982
[Gene mutation induction by the antitumor preparation ftorafur].
    Genetika, 1982, Volume: 18, Issue:5

    Topics: Animals; Azaguanine; Cell Line; Cells, Cultured; Chromosome Aberrations; Cricetinae; Dose-Response Relationship, Drug; Drug Resistance; Fluorouracil; Genes; Mutagenicity Tests; Mutagens; Mutation; Tegafur

1982
Combination chemotherapy with cyclophosphamide and ftorafur against advanced L1210 murine leukemia.
    Cancer treatment reports, 1982, Volume: 66, Issue:8

    Topics: Animals; Cyclophosphamide; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Leukemia L1210; Male; Mice; Tegafur

1982
[Chemotherapy of advanced breast cancer--actual results ].
    Archiv fur Geschwulstforschung, 1982, Volume: 52, Issue:3

    Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Methotrexate; Middle Aged; Prognosis; Tegafur; Vincristine

1982
Chemotherapeutic studies on N-nitrosoacetoxymethyl-methylamine-and 1,2-dimethylhydrazine-induced colonic tumors in rats: monotherapy with 5-fluorouracil, ftorafur, CGP 6809, and CGP 15'720A.
    Journal of cancer research and clinical oncology, 1982, Volume: 104, Issue:1-2

    Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Dimethylnitrosamine; Fluorouracil; Male; Methylhydrazines; Neoplasms, Experimental; Nitrosourea Compounds; Phenylurea Compounds; Rats; Rats, Inbred Strains; Tegafur

1982
Metabolic activation of ftorafur [R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil]: the microsomal oxidative pathway.
    Biochemical pharmacology, 1982, Sep-15, Volume: 31, Issue:18

    Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Fluorouracil; In Vitro Techniques; Male; Microsomes, Liver; Oxidation-Reduction; Rabbits; Tegafur

1982
Immunochemotherapy for advanced bladder cancer using FT-207, adriamycin and OK-432.
    The Tohoku journal of experimental medicine, 1982, Volume: 138, Issue:2

    Topics: Adjuvants, Immunologic; Aged; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Injections, Intramuscular; Streptococcus; Suppositories; Tegafur; Ultrasonography; Urinary Bladder Neoplasms

1982
Pharmacologic requirements for obtaining sensitization of human tumor cells in vitro to combined 5-Fluorouracil or ftorafur and X rays.
    International journal of radiation oncology, biology, physics, 1982, Volume: 8, Issue:11

    Topics: Cell Survival; Fluorouracil; HeLa Cells; Humans; Tegafur

1982
[Anticancer effect of levamisole and tegafur on 1,2-dimethylhydrazine (DMH)-induced colonic cancers in rats].
    Nihon Gan Chiryo Gakkai shi, 1982, Oct-20, Volume: 17, Issue:7

    Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents; Colonic Neoplasms; Dimethylhydrazines; Fluorouracil; Levamisole; Male; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Tegafur

1982
Drug interaction of antitumor drugs. III. Antitumor activity of tegafur in lipopolysaccharide-treated mice.
    Japanese journal of pharmacology, 1982, Volume: 32, Issue:6

    Topics: Animals; Antineoplastic Agents; Drug Interactions; Fluorouracil; Kidney; Lipopolysaccharides; Liver; Male; Mice; Mixed Function Oxygenases; Proteins; Tegafur; Time Factors

1982
[Significance of chemo-endocrine therapy in advanced breast cancer--a combined administration of tamoxifen, tegafur, and cyclophosphamide].
    Nihon Gan Chiryo Gakkai shi, 1982, Dec-20, Volume: 17, Issue:8

    Topics: Antineoplastic Agents; Breast Neoplasms; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Fluorouracil; Humans; Middle Aged; Tamoxifen; Tegafur

1982
[Clinical trial of UFT in recurrent or advanced cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Combinations; Drug Evaluation; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Rectal Neoplasms; Sigmoid Neoplasms; Tegafur; Uracil

1982
[Transport of FT-207 to the blood, pancreatic juice, bile, and pancreatic tissue following rectal administration].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:1

    Topics: Antineoplastic Agents; Bile; Biological Transport; Fluorouracil; Humans; Pancreas; Pancreatic Juice; Suppositories; Tegafur; Tissue Distribution

1982
[Two cases of carcinoid tumor of the stomach which responded to oral administration of UFT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:10

    Topics: Administration, Oral; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoid Tumor; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Stomach Neoplasms; Tegafur; Uracil

1982
[Clinical study of preoperative chemotherapy of primary breast cancer. 1. Efficacy of a combined use of CPA (endoxan) and FT-207 (or 5-FU dry syrup)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:12

    Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouracil; Humans; Middle Aged; Preoperative Care; Tegafur

1982
[Radiotherapy combined with tegafur for inoperable advanced gastric cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:2

    Topics: Aged; Antineoplastic Agents; Female; Fluorouracil; Humans; Male; Middle Aged; Prognosis; Stomach Neoplasms; Tegafur

1982
[Effect of FT-207 on bladder cancer in rats induced by BBN. II: The effect of oral administration of FT-207 during oncogenesis of bladder cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:3

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Body Weight; Butylhydroxybutylnitrosamine; Fluorouracil; Male; Neoplasms, Experimental; Organ Size; Rats; Rats, Inbred Strains; Tegafur; Urinary Bladder; Urinary Bladder Neoplasms

1982
[Evaluation of pre-operative chemotherapy using FT-207 suppositories combined with glutathione--with special reference to histopathological antitumor effect].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:3

    Topics: Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fluorouracil; Glutathione; Humans; Male; Preoperative Care; Stomach Neoplasms; Suppositories; Tegafur

1982
[Physiological effects and antitumor efficiency of ACNU in postoperative patients with stomach cancer--an evaluation of the treatment combined with FT-207 or 5-FU dry syrup].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:3

    Topics: Antineoplastic Agents; Bone Marrow; Carcinoembryonic Antigen; Drug Administration Schedule; Drug Therapy, Combination; Fluorouracil; Humans; Immunity, Cellular; Nimustine; Nitrosourea Compounds; Stomach Neoplasms; Tegafur

1982
[Clinical effect of UFT on bladder cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:3

    Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Tegafur; Uracil; Urinary Bladder Neoplasms

1982
[Concentration of 5-FU level in the tissue and blood of the patients with breast cancer by preoperative administration of UFT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:4

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Combinations; Female; Fluorouracil; Humans; Lymphatic Metastasis; Preoperative Care; Tegafur; Uracil

1982
[Clinical experiences with UFD-1].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:4

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Female; Fluorouracil; Humans; Kidney Neoplasms; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasms; Stomach Neoplasms; Tegafur; Uracil

1982
[A clinical investigation of the combination therapy of 1-(2-tetrahydrofuryl)-5-fluorouracil (FH) fine granules and 5-FU dry syrup].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:4

    Topics: Adult; Aged; Blood Platelets; Drug Therapy, Combination; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Tegafur

1982
[Combined administration of futraful and esquinone for the treatment of advanced ovarian cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:7

    Topics: Adenocarcinoma; Azirines; Carbazilquinone; Drug Therapy, Combination; Female; Fluorouracil; Humans; Ovarian Neoplasms; Tegafur

1982
[Tissue concentration of 5-FU following pre-operative administration of FT-207].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:7

    Topics: Female; Fluorouracil; Humans; Intestinal Neoplasms; Intestine, Large; Lymph Nodes; Male; Middle Aged; Preoperative Care; Stomach Neoplasms; Tegafur; Tissue Distribution

1982
[Clinical application of futraful suppositories in malignant head and neck cancer--effects of the therapy combined with radiation].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:8

    Topics: Aged; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Male; Middle Aged; Suppositories; Tegafur

1982
[FT-207 maintenance therapy of malignant gynecologic cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:8

    Topics: Antineoplastic Agents; Female; Fluorouracil; Humans; Middle Aged; Tegafur; Time Factors; Uterine Cervical Neoplasms; Uterine Neoplasms

1982
[Clinical survey on cardiotoxicity of tegafur (FT-207)--compilation of a nationwide survey].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:8

    Topics: Administration, Oral; Adult; Aged; Electrocardiography; Female; Fluorouracil; Heart; Humans; Infusions, Parenteral; Male; Middle Aged; Neoplasms; Tegafur

1982
[Clinical study of serum and tissue concentrations of FT-207 and 5-FU in patients with cancer of the large intestine following preoperative application of FT-207 suppositories].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:9

    Topics: Adult; Aged; Biological Assay; Female; Fluorouracil; Humans; Intestinal Neoplasms; Intestine, Large; Lymph Nodes; Male; Middle Aged; Rectal Neoplasms; Rectum; Suppositories; Tegafur; Tissue Distribution

1982
[Clinical evaluation of Tegafur suppository in the treatment of uterine cancer--with special reference to the drug concentration in the blood, secretion from the pelvic dead space, and tissues of female genital organs].
    Igaku kenkyu. Acta medica, 1982, Volume: 52, Issue:5

    Topics: Adenocarcinoma; Adult; Antineoplastic Agents; Carcinoma, Squamous Cell; Female; Fluorouracil; Genitalia, Female; Humans; Middle Aged; Pelvis; Suppositories; Tegafur; Tissue Distribution; Uterine Cervical Neoplasms; Uterine Neoplasms

1982
[Augmentation of chemotherapeutic efficaciousness of UFT by oral l-leucovorin--l-leucovorin factors enhancing cytotoxic activity of 5-fluorouracil].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1995, Volume: 22, Issue:13

    Topics: Adenocarcinoma; Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fluorouracil; Folic Acid; Humans; Leucovorin; Tegafur; Tumor Cells, Cultured; Uracil

1995
[A case of gastric cancer responding well to MTX/5-FU (methotrexate/5-fluorouracil) and PMUE (CDDP, MMC, UFT, etoposide) therapies upon lymphnode recurrence].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1995, Volume: 22, Issue:13

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Etoposide; Fluorouracil; Humans; Male; Methotrexate; Middle Aged; Mitomycin; Stomach Neoplasms; Tegafur; Uracil

1995
Pericardiac metastasis from advanced gastric cancer.
    Journal of gastroenterology, 1995, Volume: 30, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Fluorouracil; Heart Neoplasms; Humans; Lentinan; Lymphatic Metastasis; Male; Middle Aged; Mitomycin; Pericardium; Pleural Neoplasms; Punctures; Stomach Neoplasms; Tegafur

1995
[Blood levels of 5-FU and uracil on additional use of uracil in UFT therapy in gastrectomized patients].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1995, Volume: 22, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Drug Administration Schedule; Female; Fluorouracil; Gastrectomy; Humans; Male; Stomach Neoplasms; Tegafur; Uracil

1995
Fetal liver micronucleus assay in mice of 5-fluorouracil and related compounds.
    Mutation research, 1993, Volume: 291, Issue:1

    Topics: Animals; Bone Marrow; Dose-Response Relationship, Drug; Female; Fetus; Fluorouracil; Liver; Male; Mice; Mice, Inbred C3H; Micronucleus Tests; Tegafur

1993
Sensitivity of human KB cells expressing platelet-derived endothelial cell growth factor to pyrimidine antimetabolites.
    Cancer research, 1993, Dec-01, Volume: 53, Issue:23

    Topics: Cell Division; Floxuridine; Fluorouracil; Humans; KB Cells; RNA; Tegafur; Thymidine Kinase; Thymidine Phosphorylase; Transfection

1993
Postoperative prophylactic lipiodolization reduces the intrahepatic recurrence of hepatocellular carcinoma.
    American journal of surgery, 1995, Volume: 169, Issue:4

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Chemotherapy, Adjuvant; Chemotherapy, Cancer, Regional Perfusion; Disease-Free Survival; Epirubicin; Feasibility Studies; Female; Fluorouracil; Hepatectomy; Humans; Iodized Oil; Liver Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Postoperative Care; Prospective Studies; Survival Rate; Tegafur; Uracil

1995
The antitumor effect of hyperthermia combined with fluorouracil and its analogues.
    Radiation research, 1995, Volume: 142, Issue:2

    Topics: Animals; Combined Modality Therapy; Fluorouracil; Hyperthermia, Induced; Male; Mice; Mice, Inbred BALB C; Sarcoma, Experimental; Tegafur; Uracil

1995
[Case report of long-term survivor of advanced gastric cancer associated with peritoneal dissemination successfully treated with cancer chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1995, Volume: 22, Issue:1

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Fluorouracil; Gastrectomy; Humans; Leucovorin; Methotrexate; Peritoneal Neoplasms; Prognosis; Stomach Neoplasms; Tegafur; Uracil

1995
[A case of multiple liver metastasis from remnant gastric cancer responding to leucovorin.5-FU+UFT therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1995, Volume: 22, Issue:4

    Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Liver Neoplasms; Male; Neoplasm, Residual; Stomach Neoplasms; Tegafur; Uracil

1995
[Prevention of drug interactions and its countermeasure].
    The Journal of toxicological sciences, 1994, Volume: 19, Issue:3

    Topics: Animals; Arabinofuranosyluracil; Drug Interactions; Fluorouracil; Humans; Rats; Tegafur; Uracil

1994
[A case of poorly differentiated hepatic cell carcinoma which showed 90% decrease in size after chemotherapy with intraarterial infusion of mitomycin C and oral administration of tegafur].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:16

    Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Cell Division; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Mitomycin; Tegafur

1994
[Tissue concentration of tegafur suppository in patients with head and neck cancer--concentration of 5-FU in cancer tissue].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Nasal Mucosa; Paranasal Sinuses; Suppositories; Tegafur

1994
In vivo 19F NMR comparative study of 5-fluorouracil, 1-(2-tetrahydrofuryl)-5-fluorouracil (FT) and an FT-uracil coadministration system in mouse tumors.
    Chemical & pharmaceutical bulletin, 1994, Volume: 42, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Fluorine; Fluorouracil; Liver; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred ICR; Neoplasm Transplantation; Sarcoma 180; Tegafur; Uracil

1994
Oral administration of BOF-A2 to rats with lung transplanted tumors results in increased 5-fluorouracil levels.
    Japanese journal of cancer research : Gann, 1994, Volume: 85, Issue:6

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Disease Models, Animal; Drug Combinations; Drug Interactions; Fluorouracil; Lung; Lung Neoplasms; Male; Neoplasm Transplantation; Pyridines; Rats; Sarcoma, Yoshida; Tegafur; Transplantation, Heterologous; Uracil

1994
[Innate resistance to thymidylate synthase inhibition after 5-fluorouracil treatment--a rationale of combined use of cisplatin and its optimal administration dose].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:12

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Synergism; Fluorouracil; Male; Rats; Sarcoma, Yoshida; Tegafur; Thymidylate Synthase; Uracil

1994
[The concentration of FT in peripheral blood and portal blood after oral, intravenous or rectal administration].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:12

    Topics: Administration, Oral; Colonic Neoplasms; Fluorouracil; Humans; Infusions, Intravenous; Liver Neoplasms; Portal System; Suppositories; Tegafur

1994
Effect of gastrectomy on the pharmacokinetics of tegafur, uracil, and 5-fluorouracil after oral administration of a 1:4 tegafur and uracil combination.
    Cancer chemotherapy and pharmacology, 1994, Volume: 33, Issue:6

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Gastrectomy; Humans; Stomach Neoplasms; Tegafur; Time Factors; Uracil

1994
[The effect of induction chemotherapy with CBDCA, 5-FU and UFT in head and neck cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:5

    Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Drug Administration Schedule; Fluorouracil; Head and Neck Neoplasms; Humans; Infusions, Intravenous; Male; Middle Aged; Tegafur; Uracil

1994
[A comparative study on the serum and tissue 5-FU concentrations in patients with hepatocellular carcinoma after preoperative oral administration of UFT and 5'-DFUR].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:5

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Liver; Liver Neoplasms; Male; Middle Aged; Tegafur; Uracil

1994
[Relationship between tissue concentrations of 5-FU and degeneration of tissues after UFT administration in patients with bladder tumor].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:13

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Humans; Middle Aged; Tegafur; Uracil; Urinary Bladder Neoplasms

1993
[Efficacy of 48-hour infusion of 5-fluorouracil for gall bladder cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:15

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Drug Administration Schedule; Drug Evaluation; Female; Fluorouracil; Gallbladder Neoplasms; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Mitomycin; Proteoglycans; Remission Induction; Survival Rate; Tegafur

1993
The synthesis and in vitro and in vivo stability of 5-fluorouracil prodrugs which possess serum albumin binding potency.
    Biological & pharmaceutical bulletin, 1993, Volume: 16, Issue:9

    Topics: Animals; Chromatography, High Pressure Liquid; Drug Delivery Systems; Drug Stability; Fluorouracil; Half-Life; Hydrolysis; In Vitro Techniques; Prodrugs; Protein Binding; Rats; Serum Albumin; Tegafur

1993
Suppression of mammary tumors by oral administration of 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil in SHN virgin mice.
    Anti-cancer drugs, 1993, Volume: 4, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Female; Fluorouracil; Mammary Neoplasms, Experimental; Mice; Mice, Inbred Strains; Organ Size; Tegafur; Thymidine Kinase; Thymidylate Synthase; Uracil

1993
The significance of preoperative chemotherapy for early gastric carcinoma.
    Surgery today, 1993, Volume: 23, Issue:10

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Staging; Preoperative Care; Prognosis; Stomach Neoplasms; Tegafur; Uracil

1993
[Clinical efficacy of cis-diamminedichloroplatinum [II] and 5-fluorouracil (UFT) in advanced cancer of the alimentary tract].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:10

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colonic Neoplasms; Drug Administration Schedule; Esophageal Neoplasms; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Stomach Neoplasms; Tegafur; Uracil

1993
[Tissue and serum levels of 5-FU in the patients with head and neck malignant tumors--influence of a streptococcal preparation OK-432].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:10

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Immunotherapy; Lymphatic Metastasis; Male; Middle Aged; Picibanil; Tegafur; Uracil

1993
[A comparison of 5-fluorouracil concentration of 5-fluorouracil drip infusion versus orally UFT in plasma of same patients].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:10

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Female; Fluorouracil; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Tegafur; Uracil

1993
Effect of 5-fluorouracil and UFT on experimental liver metastasis model of colorectal cancer using mouse colon 26 cells.
    Japanese journal of cancer research : Gann, 1993, Volume: 84, Issue:7

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Combinations; Drug Screening Assays, Antitumor; Fluorouracil; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Tegafur; Uracil

1993
[Pharmacodynamic study on the effectiveness of UFT against cancer of gastro-intestinal (GI) tract].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:12

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Cell Count; Fluorouracil; Gastrointestinal Neoplasms; Humans; Nucleolus Organizer Region; Tegafur; Uracil

1993
[The present status of chemotherapy for hepatocellular carcinoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:7

    Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Cisplatin; Doxorubicin; Drug Delivery Systems; Fluorouracil; Humans; Infusion Pumps; Infusions, Intra-Arterial; Liver Neoplasms; Mitomycin; Survival Rate; Tegafur; Uracil

1993
A pharmacodynamic and pharmacokinetic study of fluoropyrimidines in a nude mouse system and in postoperative patients with gastric cancer.
    Surgery today, 1993, Volume: 23, Issue:8

    Topics: Adenocarcinoma; Administration, Oral; Animals; Colonic Neoplasms; Fluorouracil; Gastrectomy; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Stomach Neoplasms; Tegafur; Uracil

1993
Effects of 5-fluorouracil and a combination of tegafur and uracil (UFT) on nucleotide metabolism in L1210 ascites tumor.
    Cancer investigation, 1993, Volume: 11, Issue:5

    Topics: Animals; Deoxyribonucleotides; Fluorouracil; Injections, Intraperitoneal; Leukemia L1210; Male; Mice; Tegafur; Uracil

1993
[Studies on tissue concentration of tegafur, 5-fluorouracil, uracil after UFT administration together with the study of microangiography of colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:1

    Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Female; Fluorouracil; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; Tegafur; Uracil

1993
[A case of secondary leukemia induced by chemotherapy with a CDDP-based regimen for gastric cancer 5 years following radical resection].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Fluorouracil; Gastrectomy; Humans; Leukemia, Myeloid, Acute; Middle Aged; Mitomycin; Neoplasms, Second Primary; Proteoglycans; Stomach Neoplasms; Tegafur; Uracil

1993
[Antitumor activity of BOF-A2, a new 5-fluorouracil derivative, against human cancers xenografted in nude mice by intermittent administration].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:2

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Colorectal Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Stomach Neoplasms; Tegafur; Uracil

1993
Comparative studies on the metabolism of new fluorinated pyrimidine drugs in the liver by in vivo 19F magnetic resonance spectroscopic observation.
    Japanese journal of cancer research : Gann, 1993, Volume: 84, Issue:2

    Topics: Alanine; Animals; Dihydrouracil Dehydrogenase (NAD+); Drug Interactions; Fluorouracil; Liver; Magnetic Resonance Spectroscopy; Male; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pyridines; Rats; Rats, Wistar; Tegafur; Uracil

1993
Dependence of the thymidylate synthase inhibition rate on the interval after the last administration of tegafur in sigmoid colon cancer patients.
    Journal of surgical oncology, 1993, Volume: 52, Issue:2

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Colon, Sigmoid; Combined Modality Therapy; Drug Administration Schedule; Female; Fluorouracil; Humans; Male; Middle Aged; Sigmoid Neoplasms; Tegafur; Thymidylate Synthase; Time Factors

1993
[Evaluation of long-term administration of oral anti-cancer agent].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:5

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Humans; Male; Middle Aged; Mitomycin; Stomach Neoplasms; Tegafur; Uracil

1993
[A case of advance colon cancer responding to sequential methotrexate and 5-fluorouracil therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:5

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Humans; Liver Neoplasms; Methotrexate; Middle Aged; Remission Induction; Tegafur; Uracil

1993
White beeswax microspheres: a comparative in vitro evaluation of cumulative release of the anticancer agents fluorouracil and ftorafur.
    Die Pharmazie, 1993, Volume: 48, Issue:2

    Topics: Delayed-Action Preparations; Drug Stability; Fluorouracil; Microspheres; Particle Size; Tegafur; Waxes

1993
5-Ethynyluracil (776C85): effects on the antitumor activity and pharmacokinetics of tegafur, a prodrug of 5-fluorouracil.
    Cancer research, 1995, Dec-15, Volume: 55, Issue:24

    Topics: Animals; Carcinoma; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Enzyme Inhibitors; Fluorouracil; Male; Neoplasm Transplantation; Oxidoreductases; Prodrugs; Rats; Tegafur; Uracil

1995
[A case of common bile duct cancer responding to MMC leucovorin, 5-FU, and UFT combination chemotherapy and radiation].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1996, Volume: 23, Issue:6

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Common Bile Duct Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Mitomycin; Remission Induction; Tegafur; Uracil

1996
Antitumor activity of 1 M tegafur-0.4 M 5-chloro-2,4-dihydroxypyridine-1 M potassium oxonate (S-1) against human colon carcinoma orthotopically implanted into nude rats.
    Cancer research, 1996, Jun-01, Volume: 56, Issue:11

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Colonic Neoplasms; Drug Combinations; Fluorouracil; Humans; Neoplasm Metastasis; Neoplasm Transplantation; Oxonic Acid; Prodrugs; Pyridines; Rats; Rats, Nude; RNA; Tegafur; Transplantation, Heterologous

1996
[A case of advanced gastric cancer responding to chemotherapy and radiotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1996, Volume: 23, Issue:4

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Ethanol; Fluorouracil; Gastrectomy; Humans; Injections, Intralesional; Liver Neoplasms; Male; Picibanil; Stomach Neoplasms; Tegafur; Uracil

1996
Metabolites of 5-fluorouracil, alpha-fluoro-beta-alanine and fluoroacetic acid, directly injure myelinated fibers in tissue culture.
    Acta neuropathologica, 1996, Volume: 92, Issue:1

    Topics: Animals; Animals, Newborn; Antimetabolites, Antineoplastic; Antineoplastic Agents; Cerebellum; Culture Techniques; Fluorouracil; Immunohistochemistry; Mice; Mice, Inbred ICR; Microscopy, Phase-Contrast; Nerve Fibers, Myelinated; Tegafur

1996
High-performance liquid chromatographic determination of 5-fluorouracil and its prodrugs, tegafur and 4-deoxy-5-fluorouracil, in rat plasma.
    Journal of chromatography. B, Biomedical applications, 1996, Feb-23, Volume: 677, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Biotransformation; Calibration; Chromatography, High Pressure Liquid; Fluorouracil; Prodrugs; Rats; Spectrophotometry, Ultraviolet; Tegafur

1996
Biochemical modulation: its pharmacological basis and clinical applications. Proceedings of a meeting. Singapore, October 19, 1995.
    Oncology, 1997, Volume: 54 Suppl 1

    Topics: Antimetabolites, Antineoplastic; Drug Combinations; Fluorouracil; Humans; Prodrugs; Tegafur; Uracil

1997
Mechanism-based improvement in the therapeutic selectivity of 5-FU prodrug alone and under conditions of metabolic modulation.
    Oncology, 1997, Volume: 54 Suppl 1

    Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration Schedule; Drug Combinations; Drug Synergism; Fluorouracil; Leucovorin; Prodrugs; Rats; Tegafur; Uracil

1997
[Immunotoxic effects of a new antineoplastic agent S-1 in mice--comparison with S-1, UFT and 5-FU].
    The Journal of toxicological sciences, 1996, Volume: 21 Suppl 3

    Topics: Animals; Antibody Formation; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Blood Cell Count; Body Weight; Dose-Response Relationship, Drug; Drug Combinations; Fluorouracil; Immune System; Immune Tolerance; Immunologic Tests; Mice; Mice, Inbred BALB C; Organ Size; Oxonic Acid; Pyridines; Spleen; Tegafur; Thymus Gland; Uracil

1996
Determination of S-1 (combined drug of tegafur, 5-chloro-2,4-dihydroxypyridine and potassium oxonate) and 5-fluorouracil in human plasma and urine using high-performance liquid chromatography and gas chromatography-negative ion chemical ionization mass sp
    Journal of chromatography. B, Biomedical sciences and applications, 1997, Mar-28, Volume: 691, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Chromatography, High Pressure Liquid; Drug Combinations; Drug Stability; Fluorouracil; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Oxonic Acid; Pyridines; Sensitivity and Specificity; Tegafur

1997
[Case of acute immune hemolytic anemia developing during fluorouracil administration following surgery of colonic cancer].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1997, Apr-10, Volume: 86, Issue:4

    Topics: Anemia, Hemolytic, Autoimmune; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Combined Modality Therapy; Fluorouracil; Humans; Male; Middle Aged; Tegafur

1997
Preventive effect of 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil on colonic carcinogenesis induced by 1,2-dimethylhydrazine in rats.
    Cancer detection and prevention, 1997, Volume: 21, Issue:4

    Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Cell Differentiation; Colorectal Neoplasms; Dimethylhydrazines; Fluorouracil; Male; Rats; Tegafur; Thymidine Kinase; Thymidylate Synthase; Uracil

1997
Future directions in the adjuvant treatment of colon cancer.
    Oncology (Williston Park, N.Y.), 1997, Volume: 11, Issue:9 Suppl 10

    Topics: Antidotes; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Drug Combinations; Drug Therapy, Combination; Fluorouracil; Forecasting; Humans; Leucovorin; Tegafur; Uracil

1997
A pharmacoeconomic comparison of UFT and 5-FU chemotherapy for colorectal cancer in South America.
    Oncology (Williston Park, N.Y.), 1997, Volume: 11, Issue:9 Suppl 10

    Topics: Argentina; Brazil; Chemotherapy, Adjuvant; Colorectal Neoplasms; Costs and Cost Analysis; Drug Combinations; Drug Costs; Fluorouracil; Humans; Monte Carlo Method; South America; Tegafur; Uracil

1997
[Concentrations of 5-fluorouracil (5-FU) in serum and tissues at venous injection of tegafur or 5-FU--clinical study on colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1998, Volume: 25, Issue:4

    Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Drug Administration Schedule; Fluorouracil; Humans; Infusions, Intravenous; Tegafur

1998
Structure-activity relationship in Ftorafur (Tegafur) and related 5-FU prodrugs.
    Advances in experimental medicine and biology, 1998, Volume: 431

    Topics: Animals; Antimetabolites, Antineoplastic; Fluorouracil; Humans; Indicators and Reagents; Leukemia L1210; Mice; Mice, Inbred Strains; Molecular Structure; Prodrugs; Serum Albumin; Structure-Activity Relationship; Tegafur

1998
Colon cancer: new drug options improve on 5-FU.
    Journal of the National Cancer Institute, 1998, Jul-01, Volume: 90, Issue:13

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colonic Neoplasms; Deoxycytidine; Drug Resistance, Neoplasm; Drug Synergism; Fluorouracil; Folic Acid Antagonists; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Survival Analysis; Tegafur; Thiophenes; Thymidylate Synthase; Topoisomerase I Inhibitors; Topotecan; Treatment Outcome

1998
Preclinical antitumor efficacy of S-1: a new oral formulation of 5-fluorouracil on human tumor xenografts.
    International journal of oncology, 1998, Volume: 13, Issue:4

    Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Drug Combinations; Fluorouracil; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Oxonic Acid; Pyridines; Rats; Rats, Inbred F344; Rats, Nude; Species Specificity; Tegafur; Transplantation, Heterologous; Treatment Outcome; Tumor Cells, Cultured

1998
Comparison of 5-fluorouracil pharmacokinetics in patients receiving continuous 5-fluorouracil infusion and oral uracil plus N1-(2'-tetrahydrofuryl)-5-fluorouracil.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:9

    Topics: Adenocarcinoma; Administration, Oral; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Drug Interactions; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Prodrugs; Tegafur; Uracil

1998
[Complete remission of liver metastasis from rectal cancer following continuous oral administration of tegafur-uracil after intrahepatic arterial single injection of CDDP and 5-FU].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1998, Volume: 25, Issue:11

    Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Combinations; Fluorouracil; Hepatic Artery; Humans; Injections, Intra-Arterial; Liver Neoplasms; Male; Rectal Neoplasms; Remission Induction; Tegafur; Uracil

1998
[Combined chemotherapy with low-dose cisplatin, tegafur and uracil in a case with neck recurrence of laryngeal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1998, Volume: 25, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Fluorouracil; Humans; Laryngeal Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Tegafur; Uracil

1998
5-Fluorouracil prodrug: role of anabolic and catabolic pathway modulation in therapy of colorectal cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1995, Volume: 1, Issue:8

    Topics: Animals; Body Weight; Colorectal Neoplasms; Female; Fluorouracil; Leucovorin; Metabolic Clearance Rate; Microsomes, Liver; Prodrugs; Rats; Rats, Inbred F344; Tegafur

1995
Anticancer activity and toxicity of S-1, an oral combination of tegafur and two biochemical modulators, compared with continuous i.v. infusion of 5-fluorouracil.
    Anti-cancer drugs, 1998, Volume: 9, Issue:9

    Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Cell Division; Colorectal Neoplasms; Digestive System; Drug Combinations; Fluorouracil; Humans; Infusions, Intravenous; Neoplasm Transplantation; Oxonic Acid; Pyridines; Rats; Rats, Inbred F344; Sarcoma, Yoshida; Tegafur; Transplantation, Heterologous

1998
Treatment of advanced gastric cancer with oral etoposide, leucovorin and tegafur: experience with an oral modification of the etoposide, leucovorin and 5-fluorouracil (ELF) regimen.
    European journal of cancer (Oxford, England : 1990), 1998, Volume: 34, Issue:7

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Etoposide; Female; Fluorouracil; Humans; Leucovorin; Levoleucovorin; Male; Middle Aged; Stomach Neoplasms; Tegafur; Treatment Outcome

1998
Persistent induction of apoptosis and suppression of mitosis as the basis for curative therapy with S-1, an oral 5-fluorouracil prodrug in a colorectal tumor model.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Colorectal Neoplasms; Disease Models, Animal; Drug Combinations; Female; Fluorouracil; Mitosis; Neoplasm Transplantation; Oxonic Acid; Prodrugs; Pyridines; Rats; Rats, Inbred F344; Tegafur; Thymidylate Synthase; Treatment Outcome

1999
[Preliminary evaluation of adjuvant chemotherapy against stage Ib or II gastric cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1999, Volume: 26, Issue:3

    Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Female; Fluorouracil; Gastrectomy; Humans; Immunohistochemistry; Male; Middle Aged; Mitomycin; Retrospective Studies; Stomach Neoplasms; Survival Rate; Tegafur; Thymidine Phosphorylase; Tumor Suppressor Protein p53; Uracil

1999
[A case of advanced gallbladder cancer responding to neoadjuvant intra-arterial chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1999, Volume: 26, Issue:3

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Drug Combinations; Duodenum; Epirubicin; Female; Fluorouracil; Gallbladder Neoplasms; Hepatectomy; Humans; Infusions, Intra-Arterial; Lymph Node Excision; Middle Aged; Neoadjuvant Therapy; Pancreatectomy; Tegafur; Uracil

1999
[Effective chemo-endocrine combination therapy for obstructive-jaundice caused by multiple liver metastasis of recurrent breast cancer--a case report].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1999, Volume: 26, Issue:7

    Topics: Aged; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cholestasis; Cyclophosphamide; Doxorubicin; Drainage; Female; Floxuridine; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Mastectomy, Radical; Medroxyprogesterone Acetate; Tamoxifen; Tegafur; Toremifene; Uracil

1999
Role of preoperative chemoradiation in the management of upper third thoracic esophageal squamous cell carcinoma.
    American journal of surgery, 1999, Volume: 177, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Esophageal Neoplasms; Esophagus; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Staging; Radiotherapy, High-Energy; Survival Rate; Tegafur

1999
Patients' concerns about clinical trials in Japan.
    Lancet (London, England), 1999, Mar-20, Volume: 353, Issue:9157

    Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Clinical Protocols; Clinical Trials as Topic; Control Groups; Cyclophosphamide; Disclosure; Epirubicin; Ethical Review; Female; Fluorouracil; Humans; Informed Consent; Research Design; Tegafur; Therapeutic Human Experimentation

1999
UFT and its metabolites inhibit the angiogenesis induced by murine renal cell carcinoma, as determined by a dorsal air sac assay in mice.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:8

    Topics: 4-Butyrolactone; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cell Division; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Hydroxybutyrates; Kidney Neoplasms; Male; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neovascularization, Pathologic; Tegafur; Tumor Cells, Cultured; Uracil

1999
[Comparative study of histopathological effects of preoperative chemotherapy using UFT and in vitro MTT assay of colonoscopy specimens from patients with colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1999, Volume: 26, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Colonoscopy; Colorectal Neoplasms; Drug Administration Schedule; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Tegafur; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Uracil

1999
Complete response of a gastric primary after a short but toxic course of 'S-1' EORTC Early Clinical Studies Group.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1999, Volume: 10, Issue:9

    Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Drug Combinations; Female; Fluorouracil; Humans; Oxonic Acid; Prodrugs; Pyridines; Remission Induction; Stomach Neoplasms; Tegafur

1999
[Consideration of cancer home chemotherapy with cooperation between hospital and clinic].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1999, Volume: 26 Suppl 2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cooperative Behavior; Drug Administration Schedule; Fluorouracil; Home Care Services, Hospital-Based; Humans; Neoplasms; Quality of Life; Tegafur; Uracil

1999
[PMC (pharmacokinetic modulating chemotherapy) for advanced gastric cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1999, Volume: 26, Issue:14

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Drug Administration Schedule; Female; Fluorouracil; Gastrectomy; Humans; Infusions, Intravenous; Male; Middle Aged; Stomach Neoplasms; Survival Rate; Tegafur; Uracil

1999
[Effective and low toxicity chemoradiotherapy for distant metastatic esophageal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1999, Volume: 26, Issue:14

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Esophageal Neoplasms; Fluorouracil; Humans; Infusions, Intravenous; Lung Neoplasms; Lymphatic Metastasis; Male; Tegafur; Uracil

1999
[Long-term complete response in a case of unresectable rectal cancer following chemoradiation].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:1

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Radiotherapy Dosage; Rectal Neoplasms; Remission Induction; Tegafur; Uracil

2000
[A case of stage IVb (H2P0N4T4) gastric cancer successfully treated with neoadjuvant chemotherapy (PMFE therapy)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:2

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Etoposide; Fluorouracil; Gastrectomy; Humans; Male; Mitomycin; Neoadjuvant Therapy; Remission Induction; Stomach Neoplasms; Tegafur; Uracil

2000
[Improved QOL with cancer chemotherapy in two patients with breast cancer suffering form carcinomatous pleurisy and carcinomatous peritonitis].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Fluorouracil; Humans; Medroxyprogesterone Acetate; Middle Aged; Peritonitis; Pleurisy; Quality of Life; Tegafur; Uracil

2000
[A case of AFP-producing gastric cancer after curative operation effectively treated with chemotherapies including hepatic arterial infusion therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:5

    Topics: Adenocarcinoma; alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Doxorubicin; Female; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Middle Aged; Stomach Neoplasms; Tegafur; Uracil

2000
[Comparison of pharmacokinetics of 5-FU and alpha-fluoro-beta-alanine, a metabolite of 5-FU, in plasma after administration of UFT, tegafur, 5-FU or doxifluridine to rats].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:6

    Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; beta-Alanine; Floxuridine; Fluorouracil; Male; Rats; Rats, Sprague-Dawley; Tegafur; Uracil

2000
Reduction of 5-fluorouracil (5-FU) gastrointestinal (GI) toxicity resulting from the protection of thymidylate synthase (TS) in GI tissue by repeated simultaneous administration of potassium oxonate (Oxo) in rats.
    Cancer chemotherapy and pharmacology, 2000, Volume: 46, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Colon; Diarrhea; Digestive System; Drug Combinations; Drug Interactions; Enzyme Inhibitors; Fluorodeoxyuridylate; Fluorouracil; Ileum; Male; Oxonic Acid; Pyridines; Rats; Tegafur; Thymidylate Synthase

2000
Therapeutic effect of 1 M tegafur-0.4 M 5-chloro-2, 4-dihydroxypridine-1 M potassium oxonate (S-1) on head and neck squamous carcinoma cells.
    Cancer letters, 2000, Oct-16, Volume: 159, Issue:1

    Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Drug Combinations; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Mice, SCID; Neoplasm Transplantation; Oxonic Acid; Pyridines; Survival Rate; Tegafur; Transplantation, Heterologous; Tumor Cells, Cultured; Uracil

2000
Tissue distribution and biotransformation of potassium oxonate after oral administration of a novel antitumor agent (drug combination of tegafur, 5-chloro-2,4-dihydroxypyridine, and potassium oxonate) to rats.
    Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:10

    Topics: Administration, Oral; Allopurinol; Animals; Antimetabolites, Antineoplastic; Area Under Curve; Biotransformation; Carbon Radioisotopes; Chlorpromazine; Drug Combinations; Drugs, Chinese Herbal; Fluorouracil; Glycyrrhiza; Intestine, Small; Male; Microsomes, Liver; Oxonic Acid; Paeonia; Pyridines; Rats; Rats, Inbred Strains; Sarcoma, Yoshida; Tegafur; Tissue Distribution; Triazines; Uracil; Xanthine Oxidase

2000
[5-FU concentration in the serum and the tumor tissue after administration of UFT 200 mg/day to patients over 80 years of age with oral cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:10

    Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Fluorouracil; Humans; Male; Mouth Neoplasms; Tegafur; Uracil

2000
[A case of advanced rectal cancer with unresectable liver metastasis for which chemotherapy was markedly effective].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:10

    Topics: Adenocarcinoma; Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Fluorouracil; Humans; Infusion Pumps, Implantable; Liver Neoplasms; Middle Aged; Mitomycin; Rectal Neoplasms; Remission Induction; Tegafur; Uracil

2000
[A case report of unresectable colon cancer that disappeared following pharmacokinetic modulation chemotherapy (PMC)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:10

    Topics: Administration, Oral; Adult; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Administration Schedule; Fluorouracil; Humans; Infusions, Intravenous; Liver Neoplasms; Male; Peritoneal Neoplasms; Prognosis; Quality of Life; Remission Induction; Tegafur; Uracil

2000
Postsurgical sequential methotrexate, fluorouracil, and leucovorin for stages 3 and 4 gastric carcinoma: A preliminary study.
    Journal of surgical oncology, 2000, Volume: 75, Issue:1

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Fluorouracil; Gastrectomy; Humans; Leucovorin; Lymphatic Metastasis; Male; Methotrexate; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Stomach Neoplasms; Survival Rate; Tegafur; Uracil

2000
Effect of consecutive lower-dose cisplatin in enhancement of 5-fluorouracil cytotoxicity in experimental tumor cells in vivo.
    Cancer letters, 2000, Nov-28, Volume: 160, Issue:2

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Drug Synergism; Enzyme Induction; Fluorouracil; Folic Acid; Male; Methionine; Mice; Neoplasm Transplantation; Oxonic Acid; Pyridines; Rats; Sarcoma, Yoshida; Tegafur

2000
[A successful case of preoperative intermittent hepatic arterial infusion of high-dose 5-FU and pharmacokinetic modulating chemotherapy against unresectable liver metastasis of colon cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Drug Administration Schedule; Fluorouracil; Hepatectomy; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Sigmoid Neoplasms; Tegafur; Uracil

2000
An experimental model of tumor dormancy therapy for advanced head and neck carcinoma.
    Japanese journal of cancer research : Gann, 2000, Volume: 91, Issue:11

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Biotransformation; Cell Division; Cell Survival; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Combinations; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Isoenzymes; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Organic Chemicals; Oxonic Acid; Probucol; Prodrugs; Prostaglandin-Endoperoxide Synthases; Pyridines; Tegafur; Telomerase; Xenograft Model Antitumor Assays

2000
Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes.
    Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:12

    Topics: Antimetabolites, Antineoplastic; Aryl Hydrocarbon Hydroxylases; Baculoviridae; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2C8; Cytochrome P-450 Enzyme System; Fluorouracil; Humans; In Vitro Techniques; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Prodrugs; Recombinant Proteins; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tegafur

2000
A novel weekday-on/weekend-off UFT schedule.
    Oncology (Williston Park, N.Y.), 2000, Volume: 14, Issue:10 Suppl 9

    Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Fluorouracil; Humans; Male; Rats; Sarcoma; Survival Analysis; Tegafur; Uracil

2000
Bioactivation of tegafur to 5-fluorouracil is catalyzed by cytochrome P-450 2A6 in human liver microsomes in vitro.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:11

    Topics: Antimetabolites, Antineoplastic; Aryl Hydrocarbon Hydroxylases; Biotransformation; Catalysis; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Fluorouracil; Humans; In Vitro Techniques; Microsomes, Liver; Mixed Function Oxygenases; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tegafur

2000
[Oral chemotherapeutic agents: the roles in cancer chemotherapy].
    Nihon geka hokan. Archiv fur japanische Chirurgie, 1999, Sep-01, Volume: 68, Issue:2

    Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Fluorouracil; Humans; Neoplasms; Oxonic Acid; Pyridines; Tegafur; Uracil

1999
[A case of pulmonary metastases of breast cancer responding remarkably to combined chemotherapy with 5-fluorouracil and low-dose cisplatin].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:14

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Drug Administration Schedule; Female; Fluorouracil; Humans; Lung Neoplasms; Mastectomy; Middle Aged; Tegafur; Uracil

2000
[Outcomes of home anti-cancer chemotherapy--estimation of hepatic arterial infusion chemotherapy for patients with multiple liver metastases].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27 Suppl 3

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colonic Neoplasms; Fluorouracil; Hepatic Artery; Home Care Services; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Mitomycin; Quality of Life; Stomach Neoplasms; Survival Rate; Tegafur; Treatment Outcome; Uracil

2000
[Long survival in a case of unresectable hepatic metastasis from rectal carcinoma treated with second-look hepatectomy plus pharmacokinetic modulating chemotherapy (PMC)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2001, Volume: 28, Issue:1

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Drug Administration Schedule; Female; Fluorouracil; Hepatectomy; Hepatic Artery; Humans; Infusion Pumps; Infusions, Intra-Arterial; Liver Neoplasms; Mitomycin; Rectal Neoplasms; Reoperation; Tegafur; Uracil

2001
Dual antitumor effects of 5-fluorouracil on the cell cycle in colorectal carcinoma cells: a novel target mechanism concept for pharmacokinetic modulating chemotherapy.
    Cancer research, 2001, Feb-01, Volume: 61, Issue:3

    Topics: Adenocarcinoma; Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Division; Colorectal Neoplasms; DNA, Neoplasm; Dose-Response Relationship, Drug; Flow Cytometry; Fluorouracil; Humans; Infusions, Intravenous; Tegafur; Tumor Cells, Cultured; Uracil

2001
[A case of gastric cancer with liver metastases successfully treated with combination therapy of systemic and hepatic arterial infusion chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2001, Volume: 28, Issue:2

    Topics: Administration, Oral; Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Doxorubicin; Drug Combinations; Fluorouracil; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Liver Neoplasms; Male; Mitomycin; Stomach Neoplasms; Tegafur; Uracil

2001
[A case of advanced gastric cancer complicated with liver metastases responding remarkably to combined chemotherapy with 5-fluorouracil and low-dose cisplatin, with UFT and low-dose cisplatin for maintenance on an outpatient basis].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2001, Volume: 28, Issue:3

    Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Fluorouracil; Humans; Liver Neoplasms; Male; Stomach Neoplasms; Tegafur; Uracil

2001
National Surgical Adjuvant Breast and Bowel Project trials in colon cancer.
    Seminars in oncology, 2001, Volume: 28, Issue:1 Suppl 1

    Topics: Adjuvants, Immunologic; Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Chemotherapy, Adjuvant; Clinical Trials as Topic; Colonic Neoplasms; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Levamisole; Neoplasm Staging; Semustine; Tegafur; Vincristine

2001
Involvement of microsomal cytochrome P450 and cytosolic thymidine phosphorylase in 5-fluorouracil formation from tegafur in human liver.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:3

    Topics: Antimetabolites, Antineoplastic; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Cytosol; Dose-Response Relationship, Drug; Fluorouracil; Humans; Kinetics; Liver; Microsomes, Liver; Pyridines; Tegafur; Thymidine Phosphorylase; Time Factors

2001
Rat cytochrome p450 1A and 3A enzymes involved in bioactivation of tegafur to 5-fluorouracil and autoinduced by tegafur in liver microsomes.
    Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:6

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Fluorouracil; Male; Microsomes, Liver; Mixed Function Oxygenases; Prodrugs; Rats; Rats, Wistar; Tegafur

2001
Intestinal permeability in patients with chemotherapy-induced stomatitis.
    Journal of cancer research and clinical oncology, 2001, Volume: 127, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Deoxycytidine; Digestive System Neoplasms; Doxorubicin; Drug Evaluation; Female; Fluorouracil; Gemcitabine; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Intestinal Absorption; Intestinal Mucosa; Lactulose; Leucovorin; Male; Mannitol; Middle Aged; Paclitaxel; Permeability; Stomatitis; Tegafur; Treatment Outcome; Xylose

2001
Effects of 5-fluorouracil on the drug-metabolizing enzymes of the small intestine and the consequent drug interaction with nifedipine in rats.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:3

    Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Biotransformation; Calcium Channel Blockers; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Fluorouracil; Glucuronosyltransferase; Glutathione Transferase; Immunoblotting; Intestinal Mucosa; Intestine, Small; Male; Microsomes; NADPH-Ferrihemoprotein Reductase; Nifedipine; Oxonic Acid; Pentosyltransferases; Pyridines; Rats; Rats, Inbred Strains; Tegafur

2001
Expression of CYP2A6 in tumor cells augments cellular sensitivity to tegafur.
    Japanese journal of cancer research : Gann, 2001, Volume: 92, Issue:5

    Topics: Antimetabolites, Antineoplastic; Aryl Hydrocarbon Hydroxylases; Cell Division; Colonic Neoplasms; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Fluorouracil; Gene Expression; Humans; Hydroxylation; Microsomes; Mixed Function Oxygenases; Tegafur; Transfection; Tumor Cells, Cultured

2001
[Relationship between the anti-metastatic effect of UFT and in vitro chemosensitivity to 5-FU in metastatic tumors from orthotopic implanted colon cancer in nude rats].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2001, Volume: 28, Issue:5

    Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Drug Combinations; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Neoplasm Transplantation; Rats; Rats, Nude; Tegafur; Transplantation, Heterologous; Uracil

2001
Correct fluorouracil (5-FU) half-life comparator for a 5-FU prodrug plus a dihydropyrimidine dehydrogenase inhibitor.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Jun-01, Volume: 19, Issue:11

    Topics: Antimetabolites, Antineoplastic; Drug Combinations; Fluorouracil; Half-Life; Humans; Oxonic Acid; Pyridines; Reference Values; Statistics as Topic; Tegafur

2001
A pharmacological study of the weekday-on/weekend-off oral UFT schedule in colorectal cancer patients.
    Cancer chemotherapy and pharmacology, 2001, Volume: 47, Issue:5

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Colorectal Neoplasms; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Tegafur; Uracil

2001
[Experimental study of radiosensitizing effect of analogs of purines and pyrimidine bases in cultured HeLa cells].
    Vestnik Rossiiskoi akademii meditsinskikh nauk, 2001, Issue:8

    Topics: Allopurinol; Antimetabolites; Antimetabolites, Antineoplastic; Cell Survival; Cobalt Radioisotopes; Fluorouracil; Gamma Rays; HeLa Cells; Humans; Lethal Dose 50; Mercaptopurine; Phosphodiesterase Inhibitors; Radiation-Sensitizing Agents; Radiotherapy; Radiotherapy Dosage; Tegafur; Theophylline

2001
Complete response achieved following administration of S-1 in a patient with adrenal gland metastasis of 5-FU-resistant gastric cancer: a case report.
    Japanese journal of clinical oncology, 2001, Volume: 31, Issue:9

    Topics: Adrenal Gland Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Drug Administration Schedule; Drug Combinations; Drug Resistance, Neoplasm; Fluorouracil; Humans; Male; Middle Aged; Oxonic Acid; Pyridines; Remission Induction; Stomach Neoplasms; Tegafur

2001
[Efficacy of intraperitoneal chemotherapy for peritoneal recurrence of gastric carcinoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2001, Volume: 28, Issue:11

    Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Gastrectomy; Humans; Infusion Pumps, Implantable; Infusions, Parenteral; Mitomycin; Peritoneal Neoplasms; Stomach Neoplasms; Tegafur; Uracil

2001
Fluorouracil (5FU) pharmacokinetics in 5FU prodrug formulations with a dihydropyrimidine dehydrogenase inhibitor.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Nov-15, Volume: 19, Issue:22

    Topics: Antimetabolites, Antineoplastic; Chemistry, Pharmaceutical; Dihydrouracil Dehydrogenase (NAD+); Drug Combinations; Fluorouracil; Half-Life; Humans; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Oxonic Acid; Prodrugs; Pyridines; Tegafur

2001
Plasma, intestine and tumor levels of 5-fluorouracil in mice bearing L1210 ascites tumor following oral administration of 5-fluorouracil, UFT (mixed compound of tegafur and uracil), carmofur and 5'-deoxy-5-fluorouridine.
    Biological & pharmaceutical bulletin, 2001, Volume: 24, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Drug Combinations; Floxuridine; Fluorouracil; Intestinal Mucosa; Leukemia L1210; Male; Mice; Tegafur; Uracil

2001
Pathologic downstaging of T3-4Nx rectal cancer after chemoradiation: 5-fluorouracil vs. Tegafur.
    International journal of radiation oncology, biology, physics, 2001, Dec-01, Volume: 51, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Combined Modality Therapy; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Staging; Rectal Neoplasms; Tegafur

2001
Stereoselective metabolism and pharmacokinetics of tegafur.
    Biopharmaceutics & drug disposition, 2001, Volume: 22, Issue:2

    Topics: Antimetabolites, Antineoplastic; Fluorouracil; Humans; Neoplasms; Stereoisomerism; Tegafur

2001
Oral fluoropyrimidines: are they the equivalent of parenteral infusional 5-fluorouracil?
    Cancer investigation, 2001, Volume: 19, Issue:8

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Fluorouracil; Humans; Infusions, Intravenous; Tegafur; Uracil

2001
[A case of spindle cell type hepatocellular carcinoma responding to hepatic intra-arterial infusion chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:1

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Middle Aged; Tegafur; Uracil

2002
[Dormant chemotherapy by low-dose FP and low-dose UFT-E in recurrent gastric cancer with long-term survival--a case report].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:2

    Topics: Adenocarcinoma, Papillary; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Lymph Node Excision; Lymphatic Metastasis; Male; Middle Aged; Stomach Neoplasms; Survivors; Tegafur; Uracil

2002
[Three cases of advanced gastric cancer treated by TS-1 in combination with low-dose cisplatinum].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:2

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Oxonic Acid; Pyridines; Stomach Neoplasms; Tegafur

2002
Recent development of anti-cancer drugs for treatment of GI malignancies in Japan.
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29 Suppl 1

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Capecitabine; Deoxycytidine; Drug Combinations; Fluorouracil; Gastrointestinal Neoplasms; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Pyridines; Tegafur

2002
gamma-Hydroxybutyric acid and 5-fluorouracil, metabolites of UFT, inhibit the angiogenesis induced by vascular endothelial growth factor.
    Angiogenesis, 2001, Volume: 4, Issue:3

    Topics: Angiogenesis Inhibitors; Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Carcinoma; Carcinoma, Renal Cell; Chemotaxis; Colonic Neoplasms; DNA Replication; Drug Combinations; Endothelial Growth Factors; Endothelium, Vascular; Female; Fibroblast Growth Factor 2; Floxuridine; Fluorouracil; Humans; Intercellular Signaling Peptides and Proteins; Kidney Neoplasms; Lung Neoplasms; Lymphokines; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Neoplasm Proteins; Neovascularization, Pathologic; Prodrugs; Prostheses and Implants; Recombinant Proteins; Sodium Oxybate; Stomach Neoplasms; Tegafur; Tumor Cells, Cultured; Uracil; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Xenograft Model Antitumor Assays

2001
[A case of gastric cancer with paraaortic lymph node metastasis responding to preoperative chemotherapy and surviving 4 years and 4 months after total gastrectomy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:4

    Topics: Adenocarcinoma, Scirrhous; Aged; Antineoplastic Combined Chemotherapy Protocols; Aorta; Cisplatin; Drug Administration Schedule; Female; Fluorouracil; Gastrectomy; Humans; Leucovorin; Lymph Nodes; Lymphatic Metastasis; Methotrexate; Stomach Neoplasms; Survivors; Tegafur; Uracil

2002
[A case of complete response (CR) persisting for 2 years and 10 months from UFT-E in a patient with liver metastasis of gastric cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Drug Combinations; Fluorouracil; Gastrectomy; Humans; Leucovorin; Liver Neoplasms; Lymph Node Excision; Male; Methotrexate; Middle Aged; Remission Induction; Stomach Neoplasms; Tegafur; Uracil

2002
[A case of liver metastasis of rectal cancer demonstrating complete response to 5-FU + Leucovorin + UFT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:4

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Male; Middle Aged; Rectal Neoplasms; Remission Induction; Tegafur; Uracil

2002
[Patient preference for oral chemotherapy].
    Krankenpflege Journal, 2002, Volume: 40, Issue:1-2

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colorectal Neoplasms; Fluorouracil; Humans; Infusions, Intravenous; Patient Acceptance of Health Care; Tegafur

2002
[Capsule instead of infusion--new oral chemotherapy option].
    Krankenpflege Journal, 2002, Volume: 40, Issue:1-2

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Palliative Care; Tegafur; Uracil

2002
[A case in which TS-1, an orally-administered 5-FU chemotherapeutic agent, showed marked effectiveness against scirrhous type gastric cancer with multiple organ metastases].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:5

    Topics: Adenocarcinoma, Scirrhous; Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Female; Fluorouracil; Humans; Neoplasm Metastasis; Oxonic Acid; Pyridines; Quality of Life; Stomach Neoplasms; Tegafur

2002
[Three cases of recurrent gastric cancer responding to TS-1 therapy following combination therapy with 5-fluorouracil, mitomycin C and cisplatin].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:5

    Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Gastrectomy; Humans; Liver Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Mitomycin; Oxonic Acid; Peritoneal Neoplasms; Pyridines; Stomach Neoplasms; Tegafur

2002
[A case of unresectable gastric cancer complicated by a serious hepatic disorder and Virchow lymph node metastasis in which FP therapy and TS-1 administration were effective].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:6

    Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Combinations; Female; Fluorouracil; Humans; Liver Diseases; Lymphatic Metastasis; Oxonic Acid; Pyridines; Stomach Neoplasms; Tegafur

2002
[Concentration of FT and CDHP and 5-FU in the ascites fluid of patient with peritoneal carcinomatosis after new anti-cancer drug TS-1 oral administration].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:7

    Topics: Adenocarcinoma; Administration, Oral; Antimetabolites, Antineoplastic; Ascitic Fluid; Drug Combinations; Fluorouracil; Humans; Male; Middle Aged; Oxonic Acid; Peritoneal Neoplasms; Pyridines; Stomach Neoplasms; Tegafur

2002
[Gastric cancer with multiple liver metastases, which responded significantly to oral administration of TS-1 following intravenous FMP therapy under hospitalization].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:9

    Topics: Adenocarcinoma; Administration, Oral; Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Drug Combinations; Fluorouracil; Hospitalization; Humans; Infusions, Intravenous; Liver Neoplasms; Male; Mitomycin; Oxonic Acid; Pyridines; Stomach Neoplasms; Tegafur; Treatment Outcome

2002
[A case of unresectable rectal cancer with liver and pulmonary metastases that responded remarkably to pharmacokinetic modulating chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:9

    Topics: Adenocarcinoma; Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Fluorouracil; Humans; Infusion Pumps, Implantable; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Quality of Life; Rectal Neoplasms; Tegafur; Uracil

2002
[A trial of continuous and biweekly low-dose cisplatin and 5-FU with UFT chemotherapy for esophageal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:10

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Esophageal Neoplasms; Female; Fluorouracil; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Survival Rate; Tegafur; Uracil

2002
[A case of colon metastasis to the lung treated successfully with combined chemotherapy of CPT-11 and 5'-DFUR].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:10

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Administration Schedule; Drug Combinations; Floxuridine; Fluorouracil; Humans; Irinotecan; Lung Neoplasms; Male; Middle Aged; Rectal Neoplasms; Tegafur; Uracil

2002
Determination of the 5-fluorouracil and N1(2'-furanidyl)uracil in the presence of tegafur by zero-crossing first derivative spectrometry.
    Journal of pharmaceutical and biomedical analysis, 2002, Nov-07, Volume: 30, Issue:4

    Topics: Fluorouracil; Spectrophotometry, Ultraviolet; Tegafur

2002
Oral uracil/ftorafur (UFT) plus leucovorin as first-line chemotherapy and salvage therapy with weekly high-dose 5-fluorouracil/leucovorin for the treatment of metastatic colorectal cancer.
    Japanese journal of clinical oncology, 2002, Volume: 32, Issue:9

    Topics: Adult; Aged; Antineoplastic Agents; Colonic Neoplasms; Diarrhea; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Leucovorin; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Metastasis; Rectal Neoplasms; Salvage Therapy; Tegafur; Uracil

2002
Cytosolic and microsomal activation of doxifluridine and tegafur to produce 5-fluorouracil in human liver.
    Cancer chemotherapy and pharmacology, 2002, Volume: 50, Issue:6

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Cytosol; Floxuridine; Fluorouracil; Humans; In Vitro Techniques; Microsomes, Liver; Mixed Function Oxygenases; Steroid Hydroxylases; Tegafur; Thymidine Phosphorylase

2002
[A case of multiple liver metastases from colon cancer successfully treated with modified pharmacokinetic modulating chemotherapy using Leucovorin].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:11

    Topics: Adenocarcinoma; Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Colectomy; Colonic Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Male; Middle Aged; Remission Induction; Tegafur; Uracil

2002
[Two patients with recurrent colon cancer who underwent surgery following a combination of irinotecan and UFT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:11

    Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colectomy; Colonic Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Fluorouracil; Humans; Irinotecan; Leucovorin; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Tegafur; Uracil

2002
[A case of postoperative hepatic metastasis from gastric cancer responding to hepatic arterial infusion chemotherapy of paclitaxel].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:12

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Drug Administration Schedule; Drug Combinations; Fluorouracil; Gastrectomy; Humans; Liver Neoplasms; Male; Paclitaxel; Stomach Neoplasms; Tegafur; Uracil

2002
[5-FU pharmacokinetic study of 5-FU hepato-arterial infusion with oral UFT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:12

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Tegafur; Uracil

2002
[Modified pharmacokinetic modulation chemotherapy (PMC) with medication of UFT and intraarterial infusion of 5-FU for advanced unresectable HCC].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:13

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Drug Combinations; Female; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Survival Rate; Tegafur; Uracil

2002
[Effectiveness of chemotherapy for outpatients with gastric or colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29 Suppl 3

    Topics: Adult; Aged; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Colorectal Neoplasms; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Irinotecan; Male; Middle Aged; Outpatients; Oxonic Acid; Paclitaxel; Pyridines; Retrospective Studies; Stomach Neoplasms; Tegafur

2002
[A case of advanced gastric adenocarcinoma with mild elevation of serum SCC that responded remarkably to adjuvant chemotherapy of ADM, CDDP, ETP and 5-FU (ACVF)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:1

    Topics: Adenocarcinoma; Aged; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Doxorubicin; Drug Administration Schedule; Drug Combinations; Etoposide; Fluorouracil; Gastrectomy; Humans; Lymphatic Metastasis; Male; Oxonic Acid; Pyridines; Remission Induction; Serpins; Stomach Neoplasms; Tegafur

2003
Prevention of peritoneal metastasis of human gastric cancer cells in nude mice by S-1, a novel oral derivative of 5-Fluorouracil.
    Oncology, 2003, Volume: 64, Issue:2

    Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Disease Models, Animal; Drug Combinations; Female; Fluorouracil; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Fluorescence; Oxonic Acid; Peritoneal Neoplasms; Pyridines; Stomach Neoplasms; Tegafur; Tumor Cells, Cultured

2003
[A case report--TS-1/CDDP combined chemotherapy found effective for metastatic recurrence after operation for colon cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:2

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colon, Sigmoid; Combined Modality Therapy; Drug Administration Schedule; Drug Combinations; Fluorouracil; Gastrectomy; Humans; Infusions, Intravenous; Leucovorin; Lymphatic Metastasis; Male; Oxonic Acid; Pyridines; Sigmoid Neoplasms; Splenic Neoplasms; Stomach Neoplasms; Tegafur

2003
[A case of advanced pancreatic cancer with multiple liver metastasis that improved remarkably with use of low-dose cisplatin and TS-1].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:2

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Infusions, Intravenous; Liver Neoplasms; Male; Middle Aged; Oxonic Acid; Pancreatic Neoplasms; Pyridines; Quality of Life; Tegafur

2003
Role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity.
    British journal of cancer, 2003, Mar-24, Volume: 88, Issue:6

    Topics: Antimetabolites; Antimetabolites, Antineoplastic; Colonic Neoplasms; Fluorouracil; Gene Expression Regulation; Humans; Lung Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Tegafur; Thymidine Phosphorylase; Trifluridine; Tumor Cells, Cultured

2003
Determination of 5-fluorouracil and its prodrug tegafur in plasma and tissue by high-performance liquid chromatography in a single injection: validation for application in clinical pharmacokinetic studies.
    Therapeutic drug monitoring, 2003, Volume: 25, Issue:2

    Topics: Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Fluorouracil; Humans; Prodrugs; Tegafur; Tissue Distribution

2003
Preparation and characterization of chitosan microspheres containing doxifluridine.
    Drug development and industrial pharmacy, 2003, Volume: 29, Issue:4

    Topics: Animals; Antimetabolites, Antineoplastic; Chemistry, Pharmaceutical; Chitin; Chitosan; Drug Implants; Floxuridine; Fluorouracil; Male; Mice; Microspheres; Rats; Rats, Wistar; Tegafur

2003
Experimental study to evaluate the usefulness of S-1 in a model of peritoneal dissemination of gastric cancer.
    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2003, Volume: 6 Suppl 1

    Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Disease Models, Animal; Drug Combinations; Eating; Female; Fluorouracil; Japan; Maximum Tolerated Dose; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Oxonic Acid; Peritoneal Neoplasms; Pyridines; Stomach Neoplasms; Survival Analysis; Tegafur; Time Factors

2003
S-1 in the treatment of advanced and recurrent gastric cancer: current state and future prospects.
    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2003, Volume: 6 Suppl 1

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Forecasting; Humans; Japan; Liver Neoplasms; Lymphatic Metastasis; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Oxonic Acid; Pyridines; Severity of Illness Index; Stomach Neoplasms; Survival Analysis; Tegafur; Time Factors; Treatment Outcome

2003
Dihydropyrimidine dehydrogenase (DPD) activity in gastric cancer tissue and effect of DPD inhibitory fluoropyrimidines.
    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2003, Volume: 6 Suppl 1

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Dihydrouracil Dehydrogenase (NADP); Disease Progression; Drug Combinations; Enzyme Inhibitors; Fluorouracil; Humans; Japan; Leucovorin; Liver Neoplasms; Lymphatic Metastasis; Oxidoreductases; Oxonic Acid; Peritoneal Neoplasms; Prognosis; Pyridines; Statistics as Topic; Stomach Neoplasms; Survival Analysis; Tegafur; Treatment Outcome; Uracil

2003
NICE recommends new treatment for breast and bowel cancer.
    BMJ (Clinical research ed.), 2003, May-31, Volume: 326, Issue:7400

    Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Colonic Neoplasms; Deoxycytidine; Docetaxel; Female; Fluorouracil; Humans; Paclitaxel; Practice Guidelines as Topic; Taxoids; Tegafur; Uracil

2003
[A case of advanced gastric cancer with lymphangitis carcinomatosa of the lung, successfully treated with paclitaxel and TS-1].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:6

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Combinations; Drug Resistance, Neoplasm; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Lymphangitis; Male; Oxonic Acid; Paclitaxel; Pyridines; Stomach Neoplasms; Tegafur

2003
Effect of combination of TS-1 and low-dose cisplatin on sarcoma-180 mouse sarcoma.
    Anti-cancer drugs, 2003, Volume: 14, Issue:6

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Cisplatin; Dose-Response Relationship, Drug; Drug Combinations; Fluorouracil; Male; Mice; Oxonic Acid; Pyridines; Sarcoma 180; Tegafur; Tissue Distribution

2003
Effects of oral UFT combined with or without zoledronic acid on bone metastasis in the 4T1/luc mouse breast cancer.
    International journal of cancer, 2003, Oct-10, Volume: 106, Issue:6

    Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Bone Neoplasms; Diphosphonates; Disease Models, Animal; Drug Combinations; Female; Fluorouracil; Imidazoles; Luciferases; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Osteoclasts; Tegafur; Uracil; Zoledronic Acid

2003
[A case of multiple lung metastases from colon cancer after sigmoidectomy treated effectively by chemotherapy].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2003, Volume: 100, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colon, Sigmoid; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Irinotecan; Lung Neoplasms; Male; Middle Aged; Postoperative Complications; Sigmoid Neoplasms; Tegafur; Uracil

2003
[A case of advanced gastric cancer with liver and intra-abdominal lymph node metastasis treated by hypertensive selective chemotherapy with pharmacokinetic modulating chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:8

    Topics: Adenocarcinoma; Aged; Angiotensin II; Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Humans; Liver Neoplasms; Lymphatic Metastasis; Male; Methotrexate; Pancreatic Neoplasms; Stomach Neoplasms; Tegafur

2003
Plasma concentrations of 5-fluorouracil and F-beta-alanine following oral administration of S-1, a dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine, as compared with protracted venous infusion of 5-fluorouracil.
    British journal of cancer, 2003, Sep-01, Volume: 89, Issue:5

    Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; beta-Alanine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Enzyme Inhibitors; Fluorouracil; Gastrointestinal Neoplasms; Humans; Infusions, Intravenous; Male; Middle Aged; Oxidoreductases; Oxonic Acid; Pyridines; Tegafur; Uracil

2003
A cost comparison of oral tegafur plus uracil/folinic acid and parenteral fluorouracil for colorectal cancer in Canada.
    PharmacoEconomics, 2003, Volume: 21, Issue:14

    Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Canada; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Drug Combinations; Drug Therapy, Combination; Female; Fluorouracil; Health Care Costs; Humans; Infusions, Parenteral; Leucovorin; Male; Middle Aged; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Retrospective Studies; Tegafur; Uracil

2003
[A case of multiple liver metastases from colon cancer successfully treated with pharmacokinetic modulating chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:9

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Infusions, Intravenous; Liver Neoplasms; Middle Aged; Tegafur; Uracil

2003
Sensitive liquid chromatographic assay for the simultaneous determination of 5-fluorouracil and its prodrug, tegafur, in beagle dog plasma.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2003, Oct-05, Volume: 795, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Calibration; Chromatography, High Pressure Liquid; Dogs; Fluorouracil; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Tegafur

2003
Superior antitumour activity of S-1 in tumours with a high dihydropyrimidine dehydrogenase activity.
    European journal of cancer (Oxford, England : 1990), 2003, Volume: 39, Issue:16

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Drug Combinations; Fluorouracil; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Oxonic Acid; Pyridines; RNA, Neoplasm; Stomach Neoplasms; Tegafur; Thymidylate Synthase; Xenograft Model Antitumor Assays

2003
[Results of prophylactic hepatic arterial chemotherapy for liver metastases of Dukes C colorectal cancer--correlation with tumoral expression of dihydropyrimidine dehydrogenase, thymidylate synthase, p53, or orotate phosphoribosyl transferase].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:11

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Female; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Orotate Phosphoribosyltransferase; Proportional Hazards Models; RNA, Messenger; Tegafur; Thymidylate Synthase; Tumor Suppressor Protein p53; Uracil

2003
[A case of liver and lung metastases of rectal cancer responding well to 5-FU hepato-arterial infusion (HAI) with combined use of oral UFT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:11

    Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Drug Combinations; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Lung Neoplasms; Male; Rectal Neoplasms; Tegafur; Uracil

2003
[A case of hepatic metastasis and local recurrence from rectal cancer responding to hepatic arterial infusion and systemic chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:11

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Administration Schedule; Drug Combinations; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Male; Neoplasm Recurrence, Local; Rectal Neoplasms; Tegafur; Uracil

2003
[Pancytopenia and ARDS with high dose hepatic arterial infusion].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:11

    Topics: Aged; Antimetabolites, Antineoplastic; Cisplatin; Drug Combinations; Female; Fluorouracil; Gastrectomy; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Oxonic Acid; Pancytopenia; Pyridines; Respiratory Distress Syndrome; Stomach Neoplasms; Tegafur

2003
[Long-term survival after neck lymph node metastases from sigmoid colon cancer--a case report].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:11

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colon, Sigmoid; Combined Modality Therapy; Drug Combinations; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Lymph Nodes; Lymphatic Metastasis; Neck; Sigmoid Neoplasms; Survivors; Tegafur; Uracil

2003
Modified pharmacokinetic modulating chemotherapy using 5-fluorouracil, UFT, and taxotere (docetaxel) for advanced gastric cancer.
    International journal of clinical oncology, 2003, Volume: 8, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Docetaxel; Fluorouracil; Humans; Infusions, Intravenous; Lymphatic Metastasis; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Stomach Neoplasms; Taxoids; Tegafur; Treatment Outcome; Uracil

2003
A case of prurigo-type drug eruptions due to UFT.
    The Journal of dermatology, 2003, Volume: 30, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biopsy, Needle; Breast Neoplasms; Drug Eruptions; Female; Fluorouracil; Follow-Up Studies; Humans; Immunohistochemistry; Middle Aged; Prurigo; Risk Assessment; Tegafur

2003
[Support of TS-1, 5-FU preparation containing potent DPD inhibitor by determination of urinary uracil/serum 5-FU clearance].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:13

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Oxonic Acid; Pyridines; Stomach Neoplasms; Tegafur; Uracil

2003
[A case of advanced gastric cancer with multiple liver metastases responding completely to hepatic arterial infusion and systemic chemotherapies].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:13

    Topics: Adenocarcinoma; Administration, Oral; Adult; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Drug Combinations; Fluorouracil; Gastrectomy; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Remission Induction; Stomach Neoplasms; Tegafur; Uracil

2003
18F-FDG positron emission tomography staging and restaging in rectal cancer treated with preoperative chemoradiation.
    International journal of radiation oncology, biology, physics, 2004, Feb-01, Volume: 58, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Fluorodeoxyglucose F18; Fluorouracil; Humans; Liver Neoplasms; Male; Neoplasm Staging; Prospective Studies; Radiopharmaceuticals; Radiotherapy Dosage; Rectal Neoplasms; Tegafur; Tomography, Emission-Computed

2004
[A case of gastric cancer with a synchronous hepatic metastasis responding to postoperative oral administration of UFT and intermittent intrahepatic arterial chemotherapy of 5-FU].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:3

    Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Drug Combinations; Fluorouracil; Gastrectomy; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Lymph Node Excision; Male; Neoplasms, Multiple Primary; Remission Induction; Stomach Neoplasms; Tegafur; Uracil

2004
[A case of highly advanced ascending colon cancer with multiple bone and liver metastases and pleuritis carcinomatosa treated with pharmacokinetic modulating chemotherapy and low-dose CPT-11].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:3

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Camptothecin; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Male; Middle Aged; Pleurisy; Quality of Life; Tegafur; Uracil

2004
Adjuvant chemotherapy for adenocarcinoma of the lung--is the standard of care ready for change?
    The New England journal of medicine, 2004, Apr-22, Volume: 350, Issue:17

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Chemotherapy, Adjuvant; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Fluorouracil; Humans; Lung Neoplasms; Prodrugs; Tegafur; Uracil

2004
Alternate-day oral therapy with TS-1 for advanced gastric cancer.
    International journal of clinical oncology, 2004, Volume: 9, Issue:3

    Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Middle Aged; Oxonic Acid; Pyridines; Stomach Neoplasms; Tegafur; Treatment Outcome

2004
[Tumoral dihydropyrimidine dehydrogenase expression and efficacy of 5-fluorouracil plus leucovorin plus UFT therapy in patients with colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Tegafur; Uracil

2004
S-1-induced, prolonged complete regression of lung metastasis from gastric cancer refractory to 5'-DFUR: a case report with pharmacokinetic study.
    Japanese journal of clinical oncology, 2004, Volume: 34, Issue:5

    Topics: Adenocarcinoma, Mucinous; Administration, Oral; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Drug Administration Schedule; Drug Combinations; Esophagectomy; Female; Floxuridine; Fluorouracil; Gastrectomy; Humans; Lung Neoplasms; Middle Aged; Oxonic Acid; Pyridines; Radiography, Thoracic; Remission Induction; Stomach Neoplasms; Tegafur; Tomography, X-Ray Computed

2004
Safety and efficacy of S-1, a novel oral fluorouracil antitumor drug, for a chronic renal failure patient maintained on hemodialysis.
    Oncology, 2004, Volume: 66, Issue:5

    Topics: Administration, Oral; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Kidney Failure, Chronic; Liver Neoplasms; Male; Oxonic Acid; Pyridines; Renal Dialysis; Stomach Neoplasms; Tegafur; Tomography, X-Ray Computed

2004
Dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine S-1 may be effective against peritoneal dissemination in gastric cancer.
    Oncology reports, 2004, Volume: 12, Issue:5

    Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Ascites; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Female; Fluorouracil; Injections, Intraperitoneal; Mice; Mice, Inbred BALB C; Mice, Nude; Oxonic Acid; Peritoneal Neoplasms; Pyridines; Stomach Neoplasms; Survival Rate; Tegafur; Tumor Cells, Cultured

2004
Schedule-dependent synergism of vinorelbine and 5-fluorouracil/UFT against non-small cell lung cancer.
    International journal of oncology, 2004, Volume: 25, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Disease Models, Animal; Drug Administration Schedule; Drug Interactions; Fluorouracil; Humans; Immunohistochemistry; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Survival Analysis; Tegafur; Thymidylate Synthase; Transplantation, Heterologous; Tumor Cells, Cultured

2004
[A case of successful management of nonresectable pancreas cancer with liver metastasis by intra-arterial infusion chemotherapy with gemcitabine hydrochloride, 5-FU, CDDP and administration of tegafur/uracil].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:10

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Deoxycytidine; Drug Administration Schedule; Drug Combinations; Fluorouracil; Gemcitabine; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms; Male; Pancreatic Neoplasms; Quality of Life; Tegafur; Uracil

2004
[Gastric cancer with liver metastasis effectively treated by intra-hepatic arterial infusion].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:11

    Topics: Administration, Oral; Adult; Aged; Agmatine; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Combinations; Female; Fluorouracil; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Mitomycin; Oxonic Acid; Proteoglycans; Pyridines; Stomach Neoplasms; Succinates; Tegafur; Treatment Outcome

2004
[A case report of the 8 year survivor--unresectable liver metastases from advanced gastric cancer (Stage IV) were completely responsive, after 4 years from a total sequential gastrectomy, combining docetaxel treatment to regress the recurrence].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:11

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Docetaxel; Drug Combinations; Fluorouracil; Gastrectomy; Hepatectomy; Humans; Infusions, Intravenous; Liver Neoplasms; Male; Oxonic Acid; Pyridines; Stomach Neoplasms; Taxoids; Tegafur

2004
[Three successful case reports of advanced gastric cancer with chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:11

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; CA-19-9 Antigen; Cisplatin; Drug Administration Schedule; Drug Combinations; Fluorouracil; Gastrectomy; Humans; Infusions, Intravenous; Liver Neoplasms; Male; Oxonic Acid; Pyridines; Stomach Neoplasms; Tegafur

2004
[A case of successful treatment with combined 5-fluorouracil, adriamycin, cisplatin (FAP) therapy followed by Gemcitabine, UFT therapy and intra-arterial FAP therapy for unresectable advanced gallbladder cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Deoxycytidine; Doxorubicin; Female; Fluorouracil; Gallbladder Neoplasms; Gemcitabine; Humans; Middle Aged; Tegafur; Uracil

2004
[The 5-fluorouracil hepato-arterial infusion with oral UFT therapy for the hepatic and extra hepatic metastases of colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:11

    Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration Schedule; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Tegafur; Uracil

2004
[A case report--Efficacy of combination therapy to unresectable advanced gall bladder carcinoma--palliative operation, hepatic arterial infusion therapy, and radiation therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:11

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Combined Modality Therapy; Drug Combinations; Duodenal Neoplasms; Fluorouracil; Gallbladder Neoplasms; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Mitomycin; Palliative Care; Stents; Tegafur; Uracil

2004
[A case of long-term survivor with multiple pulmonary metastases of HCC after hepatic resection].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Cisplatin; Drug Combinations; Fluorouracil; Hepatectomy; Humans; Interferon-alpha; Interferon-beta; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Oxonic Acid; Pyridines; Tegafur; Time Factors; Uracil

2004
Immunohistochemical evaluation of thymidylate synthase (TS) and p16INK4a in advanced colorectal cancer: implication of TS expression in 5-FU-based adjuvant chemotherapy.
    Japanese journal of clinical oncology, 2004, Volume: 34, Issue:10

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Chemotherapy, Adjuvant; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p16; Drug Combinations; Female; Fluorouracil; Humans; Immunohistochemistry; Male; Middle Aged; Neoplasm Invasiveness; Postoperative Period; Rectal Neoplasms; Tegafur; Thymidylate Synthase; Uracil

2004
[Two cases of gastric cancer with multiple liver metastases responding to TS-1 with hepatic arterial infusion of CDDP following low-dose 5-FU and CDDP chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:1

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Fluorouracil; Gastrectomy; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms; Lymph Node Excision; Male; Oxonic Acid; Pyridines; Quality of Life; Stomach Neoplasms; Tegafur

2005
[A case of liver metastases from cecal cancer successfully treated with fluorouracil and folinic acid (UFT/LV)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:2

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Cecal Neoplasms; Chemotherapy, Adjuvant; Colectomy; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Male; Tegafur; Uracil

2005
[Pharmacokinetic modulating chemotherapy for rectal carcinoma metastases to the liver and lung--a case report].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:2

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Rectal Neoplasms; Tegafur; Uracil

2005
[Modified pharmacokinetic modulating chemotherapy for progressive gastric cancer accompanied by peritoneal dissemination].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:4

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Angiotensin II; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Male; Methotrexate; Middle Aged; Peritoneal Neoplasms; Stomach Neoplasms; Survival Rate; Tegafur; Uracil

2005
[A case of advanced gastric cancer with bone metastasis and severe DIC responding to hypertensive subselective chemotherapy with pharmacokinetic modulating chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:4

    Topics: Angiotensin II; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carcinoma, Signet Ring Cell; Disseminated Intravascular Coagulation; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Infusion Pumps, Implantable; Methotrexate; Middle Aged; Paclitaxel; Quality of Life; Stomach Neoplasms; Tegafur; Uracil

2005
Effects of oral 5-fluorouracil drugs on hepatic fat content in patients with colon cancer.
    Academic radiology, 2005, Volume: 12, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Chi-Square Distribution; Colonic Neoplasms; Fatty Liver; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Retrospective Studies; Tegafur; Tomography, X-Ray Computed; Uracil

2005
Correlations between antitumor activities of fluoropyrimidines and DPD activity in lung tumor xenografts.
    Oncology reports, 2005, Volume: 14, Issue:1

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cell Line, Tumor; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Floxuridine; Fluorouracil; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Orotate Phosphoribosyltransferase; Oxonic Acid; Pyridines; Tegafur; Thymidine Phosphorylase; Treatment Outcome; Uracil; Xenograft Model Antitumor Assays

2005
[TS-1 treatment for progressive gastric cancer in a patient on chronic dialysis--assessment of dosage regimen by monitoring blood concentrations of therapeutic drugs (TDM)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:6

    Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Area Under Curve; Drug Administration Schedule; Drug Combinations; Drug Monitoring; Fluorouracil; Gastrectomy; Humans; Kidney Failure, Chronic; Male; Oxonic Acid; Peritoneal Neoplasms; Pyridines; Renal Dialysis; Stomach Neoplasms; Tegafur

2005
[Pharmacokinetics and adverse event of TS-1 administered through gastrostomy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:6

    Topics: Deglutition Disorders; Drug Administration Schedule; Drug Combinations; Fluorouracil; Gas Chromatography-Mass Spectrometry; Gastrostomy; Humans; Informed Consent; Intubation, Gastrointestinal; Male; Middle Aged; Oropharyngeal Neoplasms; Oxonic Acid; Pyridines; Tegafur

2005
Leflunomide and peripheral neuropathy: a potential interaction between uracil/tegafur and leflunomide.
    Clinical pharmacology and therapeutics, 2005, Volume: 78, Issue:1

    Topics: Administration, Oral; Aged; Arthritis, Rheumatoid; Comorbidity; Disease Progression; Drug Administration Schedule; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Fluorouracil; Humans; Isoxazoles; Leflunomide; Male; Peripheral Nervous System Diseases; Polyneuropathies; Rectal Neoplasms; Tegafur; Time Factors; Uracil

2005
[Combined chemotherapy with oral leucovorin (LV) + tegafur/uracil (UFT) and hepatic arterial infusion (HAI) therapy for liver metastasis of colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:7

    Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Male; Middle Aged; Tegafur; Uracil

2005
Sensitive MS/MS-liquid chromatography assay for simultaneous determination of tegafur, 5-fluorouracil and 5-fluorodihydrouracil in plasma.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005, Sep-25, Volume: 824, Issue:1-2

    Topics: Chromatography, High Pressure Liquid; Fluorouracil; Humans; Mass Spectrometry; Reproducibility of Results; Tegafur; Time Factors

2005
[Stage IV gastric cancer patient who underwent palliative gastrectomy showing complete response to induction therapy with methotrexate plus 5-fluorouracil and secondary treatment with oral TS-1].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:8

    Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; CA-19-9 Antigen; Carcinoembryonic Antigen; Carcinoma, Signet Ring Cell; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Gastrectomy; Humans; Leucovorin; Lymphatic Metastasis; Methotrexate; Oxonic Acid; Palliative Care; Pyridines; Stomach Neoplasms; Tegafur

2005
Just when you thought the fluorouracil debate was over: S-1 and gastric cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Oct-01, Volume: 23, Issue:28

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Infusions, Intravenous; Oxonic Acid; Pyridines; Stomach Neoplasms; Tegafur

2005
Enhancement of the anti-tumor activity of S-1 by low-dose cisplatin in mice bearing the sarcoma-180 model.
    Anti-cancer drugs, 2005, Volume: 16, Issue:10

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cisplatin; Drug Combinations; Fluorouracil; Male; Mice; Mice, Inbred Strains; Oxonic Acid; Pyridines; RNA, Neoplasm; Sarcoma 180; Tegafur; Thymidine Kinase; Uridine Triphosphate

2005
Preoperative chemoradiation of locally advanced T3 rectal cancer combined with an endorectal boost.
    International journal of radiation oncology, biology, physics, 2006, Feb-01, Volume: 64, Issue:2

    Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; Combined Modality Therapy; Feasibility Studies; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Staging; Radiotherapy Dosage; Rectal Neoplasms; Remission Induction; Tegafur

2006
[Treatment strategy for primary gastric cancer with peritoneal dissemination].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Drug Combinations; Fluorouracil; Gastrectomy; Humans; Lymph Node Excision; Methotrexate; Oxonic Acid; Paclitaxel; Peritoneal Neoplasms; Pyridines; Stomach Neoplasms; Survival Rate; Tegafur

2005
[Case report--postoperative continuous intraarterial infusion of small doses of 5-FU successfully controlled residual tumor and liver metastasis of stage IV gastric cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:10

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; Doxorubicin; Drug Combinations; Floxuridine; Fluorouracil; Gastrectomy; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Lymph Node Excision; Lymph Nodes; Lymphatic Metastasis; Male; Methotrexate; Mitomycin; Neoplasm Staging; Picibanil; Proteoglycans; Stomach Neoplasms; Tegafur; Uracil

2005
[A case of colon cancer with multiple liver, lung and bone metastases successfully treated with combined weekly high-dose 5-FU (WHF) chemotherapy with UFT and CPT-11].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:10

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Camptothecin; Colectomy; Colonic Neoplasms; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Irinotecan; Liver Neoplasms; Lung Neoplasms; Middle Aged; Tegafur; Uracil

2005
Diamine oxidase, a plasma biomarker in rats to GI tract toxicity of oral fluorouracil anti-cancer drugs.
    Toxicology, 2006, Jan-16, Volume: 217, Issue:2-3

    Topics: Administration, Oral; Amine Oxidase (Copper-Containing); Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biomarkers; Body Weight; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Intestinal Mucosa; Jejunal Diseases; Male; Orotate Phosphoribosyltransferase; Oxonic Acid; Pyridines; Rats; Rats, Sprague-Dawley; Tegafur

2006
[Effect of intraperitoneal chemotherapy on experimental peritoneal dissemination of gastric cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:11

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Carboplatin; Cisplatin; Docetaxel; Drug Combinations; Drug Screening Assays, Antitumor; Fluorouracil; Infusions, Parenteral; Mice; Mice, Nude; Neoplasm Seeding; Oxonic Acid; Peritoneal Neoplasms; Pyridines; Stomach Neoplasms; Taxoids; Tegafur

2005
[Hepatic arterial infusion (HAI) chemotherapy achieved a complete response (CR) for multiple liver metastases of colorectal cancer--two case reports].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:11

    Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colorectal Neoplasms; Fluorouracil; Hepatectomy; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Remission Induction; Tegafur; Uracil

2005
Potassium oxonate, an enzyme inhibitor compounded in S-1, reduces the suppression of antitumor immunity induced by 5-fluorouracil.
    Cancer chemotherapy and pharmacology, 2006, Volume: 58, Issue:2

    Topics: Animals; Drug Combinations; Enzyme Inhibitors; Fluorouracil; Immunophenotyping; Interleukin-2; Killer Cells, Natural; Male; Neoplasms, Experimental; Oxonic Acid; Pyridines; Rats; Tegafur

2006
[Combination therapy with TS-1].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:13

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell; Cisplatin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Combined Modality Therapy; Docetaxel; Drug Administration Schedule; Drug Combinations; Fluorouracil; Head and Neck Neoplasms; Humans; Organoplatinum Compounds; Oxonic Acid; Pyridines; Taxoids; Tegafur

2005
5-Fluorouracil cardiotoxicity induced by alpha-fluoro-beta-alanine.
    International journal of clinical oncology, 2005, Volume: 10, Issue:6

    Topics: Aged; Antimetabolites, Antineoplastic; beta-Alanine; Cardiovascular Diseases; Colonic Neoplasms; Drug Combinations; Electrocardiography; Fluorouracil; Heart; Humans; Liver Neoplasms; Lung Neoplasms; Male; Oxonic Acid; Tegafur

2005
Chemotherapy of metastatic colorectal cancer: fluorouracil plus folinic acid and irinotecan or oxaliplatin.
    Prescrire international, 2005, Volume: 14, Issue:80

    Topics: Antibodies, Monoclonal; Antineoplastic Agents; Camptothecin; Chemotherapy, Adjuvant; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Drug Therapy, Combination; Fluorouracil; Humans; Leucovorin; Neoplasm Metastasis; Organoplatinum Compounds; Quinazolines; Tegafur; Thiophenes; Treatment Outcome; Uracil

2005
Prognostic factors for disease-free survival in patients with T3-4 or N+ rectal cancer treated with preoperative chemoradiation therapy, surgery, and intraoperative irradiation.
    International journal of radiation oncology, biology, physics, 2006, Mar-15, Volume: 64, Issue:4

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Disease-Free Survival; Drug Administration Schedule; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Staging; Prognosis; Radiotherapy; Radiotherapy Dosage; Rectal Neoplasms; Recurrence; Sex Factors; Statistics as Topic; Tegafur

2006
Effect of gastrectomy on the pharmacokinetics of 5-fluorouracil and gimeracil after oral administration of S-1.
    Anti-cancer drugs, 2006, Volume: 17, Issue:4

    Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Drug Combinations; Female; Fluorouracil; Gastrectomy; Humans; Male; Middle Aged; Oxonic Acid; Pyridines; Stomach Neoplasms; Tegafur; Time Factors

2006
Synergistic effects of docetaxel and S-1 by modulating the expression of metabolic enzymes of 5-fluorouracil in human gastric cancer cell lines.
    International journal of cancer, 2006, Aug-15, Volume: 119, Issue:4

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Dihydrouracil Dehydrogenase (NADP); Docetaxel; Drug Combinations; Drug Synergism; Female; Fluorouracil; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Nude; Multienzyme Complexes; Orotate Phosphoribosyltransferase; Orotidine-5'-Phosphate Decarboxylase; Oxonic Acid; Stomach Neoplasms; Taxoids; Tegafur; Thymidylate Synthase; Xenograft Model Antitumor Assays

2006
[Experimental chemotherapy against human esophageal carcinoma xenografts with TS-1, cisplatin and docetaxel].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Docetaxel; Drug Combinations; Drug Synergism; Esophageal Neoplasms; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Oxonic Acid; Pyridines; Succinate Dehydrogenase; Taxoids; Tegafur; Thymidylate Synthase; Tumor Cells, Cultured

2006
Guides for adjuvant treatment of colon cancer. TTD Group (Spanish Cooperative Group for Gastrointestinal Tumor Therapy).
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2006, Volume: 8, Issue:2

    Topics: Adenocarcinoma; Algorithms; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemotherapy, Adjuvant; Colorectal Neoplasms; Deoxycytidine; Drug Administration Schedule; Fluorouracil; Humans; Leucovorin; Lymphatic Metastasis; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Randomized Controlled Trials as Topic; Risk Assessment; Tegafur; Uracil

2006
Improved incidence of pT0 downstaged surgical specimens in locally advanced rectal cancer (LARC) treated with induction oxaliplatin plus 5-fluorouracil and preoperative chemoradiation.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2006, Volume: 17, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Preoperative Care; Radiotherapy Dosage; Rectal Neoplasms; Tegafur

2006
[A case of hepatic metastases of sigmoid colon cancer which completely responded to systemic l-leucovorin/5-FU therapy and oral LV/UFT combination therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:5

    Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Male; Sigmoid Neoplasms; Tegafur; Uracil

2006
TS-1 as first-line therapy for gastric linitis plastica: historical control study.
    Anti-cancer drugs, 2006, Volume: 17, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Combinations; Female; Fluorouracil; Humans; Linitis Plastica; Male; Methotrexate; Middle Aged; Mitomycin; Oxonic Acid; Pyridines; Retrospective Studies; Stomach Neoplasms; Survival Analysis; Tegafur

2006
Simple combinations of 5-FU pathway genes predict the outcome of metastatic gastric cancer patients treated by S-1.
    International journal of cancer, 2006, Oct-15, Volume: 119, Issue:8

    Topics: Adult; Aged; Drug Combinations; Drug Therapy, Combination; Female; Fluorouracil; Gene Expression; Humans; Male; Middle Aged; Neoplasm Metastasis; Oxonic Acid; Stomach Neoplasms; Survival Rate; Tegafur; Treatment Outcome

2006
S-1 (TS-1) maintained complete response for approximately 10 years in a case of metastatic breast cancer.
    Breast cancer (Tokyo, Japan), 2006, Volume: 13, Issue:2

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Biopsy, Needle; Breast Neoplasms; Carcinoma, Ductal, Breast; Chemotherapy, Adjuvant; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluorouracil; Follow-Up Studies; Humans; Immunohistochemistry; Lung Neoplasms; Mastectomy, Modified Radical; Middle Aged; Neoplasm Staging; Remission Induction; Risk Assessment; Tamoxifen; Tegafur; Time Factors; Treatment Outcome

2006
[Second-line chemotherapy with pharmacokinetic modulating chemotherapy for unresectable colorectal carcinoma recurrences resistant to 5-FU-based chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:6

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chronotherapy; Colonic Neoplasms; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Liver Neoplasms; Lung Neoplasms; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Rectal Neoplasms; Survival Rate; Tegafur; Uracil

2006
Quality of Life assessment through the EORTC questionnaires of locally advanced rectal cancer patients treated with preoperative chemo-radiotherapy.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2006, Volume: 8, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Body Image; Emotions; Female; Fluorouracil; Follow-Up Studies; Gastrointestinal Diseases; Humans; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Preoperative Care; Quality of Life; Radiotherapy; Rectal Neoplasms; Sexual Behavior; Surveys and Questionnaires; Tegafur; Urination Disorders

2006
Pharmacokinetics of S-1 in patients with peritoneal dissemination of gastric cancer.
    Oncology reports, 2006, Volume: 16, Issue:2

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Biological Availability; Drug Combinations; Female; Fluorouracil; Humans; Lymph Nodes; Male; Middle Aged; Oxonic Acid; Peritoneal Neoplasms; Peritoneum; Pyridines; Stomach Neoplasms; Tegafur

2006
Retrospective analysis on prognostic impact of adjuvant chemotherapy in the patients with advanced and resectable oral squamous cell carcinoma.
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:7

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Cisplatin; Disease-Free Survival; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Mouth Neoplasms; Neck; Neoadjuvant Therapy; Neoplasm Staging; Prognosis; Proportional Hazards Models; Radiotherapy Dosage; Retrospective Studies; Survival Rate; Tegafur; Uracil

2006
[A case of long-term survival of gastric cancer with peritoneal metastasis effectively treated by TS-1 and paclitaxel (PTX) combination therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Constriction, Pathologic; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Middle Aged; Oxonic Acid; Paclitaxel; Peritoneal Neoplasms; Sigmoid Diseases; Stomach Neoplasms; Tegafur

2006
S-1, an oral fluoropyrimidine, enhances radiation response of DLD-1/FU human colon cancer xenografts resistant to 5-FU.
    Oncology reports, 2006, Volume: 16, Issue:3

    Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colorectal Neoplasms; Drug Combinations; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Oxonic Acid; Radiation-Sensitizing Agents; Tegafur; Xenograft Model Antitumor Assays

2006
Schedule-dependent therapeutic effects of gemcitabine combined with uracil-tegafur in a human pancreatic cancer xenograft model.
    Pancreas, 2006, Volume: 33, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Survival; Deoxycytidine; Drug Administration Schedule; Drug Combinations; Equilibrative Nucleoside Transporter 1; Fluorouracil; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Pancreatic Neoplasms; RNA, Messenger; Tegafur; Uracil; Xenograft Model Antitumor Assays

2006
Tegafur and 5-fluorouracil pelvic tissue concentrations in rectal cancer patients receiving preoperative chemoradiation.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2006, Volume: 8, Issue:7

    Topics: Adipose Tissue; Adult; Aged; Antimetabolites, Antineoplastic; Female; Fluorouracil; Humans; Intestinal Mucosa; Male; Middle Aged; Neoplasm, Residual; Pelvis; Rectal Neoplasms; Rectum; Tegafur; Treatment Outcome

2006
Evaluations of biomarkers associated with 5-FU sensitivity for non-small-cell lung cancer patients postoperatively treated with UFT.
    British journal of cancer, 2006, Sep-04, Volume: 95, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Female; Fluorouracil; Humans; Immunohistochemistry; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Survival Analysis; Tegafur; Uracil

2006
[Antitumor activity and function of S-1, a new oral tegafur-based formulation].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33 Suppl 1

    Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Mice; Neoplasm Transplantation; Neoplasms; Oxonic Acid; Pharmaceutical Preparations; Rats; Sarcoma, Yoshida; Tegafur; Uracil

2006
[Plasma concentrations of 5-fluorouracil and F-beta-alanine following oral administration of S-1, a dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine, as compared with protracted venous infusion of 5-fluorouracil].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33 Suppl 1

    Topics: beta-Alanine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Fluorouracil; Humans; Infusions, Intravenous; Kidney; Oxonic Acid; Stomach Neoplasms; Tegafur; Uracil

2006
[Long-term repeatable chemotherapy for patients with advanced pancreatic cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33 Suppl 1

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Irinotecan; Male; Middle Aged; Neoplasm Staging; Oxonic Acid; Paclitaxel; Pancreatic Neoplasms; Quality of Life; Remission Induction; Survival Rate; Tegafur

2006
[A case of advanced esophageal cancer with suspected tracheoesophageal fistula that responded to chemoradiotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Drug Combinations; Esophageal Neoplasms; Fluorouracil; Humans; Male; Middle Aged; Quality of Life; Radiotherapy Dosage; Remission Induction; Stents; Tegafur; Trachea; Tracheal Stenosis; Tracheoesophageal Fistula; Uracil

2006
A case of early relapsed multiple lung metastases after esophagectomy successfully treated with S-1/cisplatin therapy after docetaxel/5-fluorouracil/cisplatin therapy.
    The journal of medical investigation : JMI, 2006, Volume: 53, Issue:3-4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Docetaxel; Drug Combinations; Esophageal Neoplasms; Esophagectomy; Fluorouracil; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Oxonic Acid; Recurrence; Taxoids; Tegafur

2006
[A case of advanced gastric cancer with liver metastasis completely responding to CPT-11+low-dose 5-FU+CDDP chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:9

    Topics: Adenocarcinoma; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cardia; Cisplatin; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Irinotecan; Liver Neoplasms; Male; Middle Aged; Oxonic Acid; Remission Induction; Stomach Neoplasms; Tegafur

2006
[A case of effective multidisciplinary treatment with hepatic resection for synchronous multiple liver metastases from rectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:10

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Doxorubicin; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Liver Neoplasms; Male; Middle Aged; Mitomycin; Quality of Life; Rectal Neoplasms; Remission Induction; Tegafur; Uracil

2006
[Partial response of liver metastasis from colon cancer following intermittent oral administration of TS-1 after intra-hepatic arterial single injection of CDDP, doxorubicin and 5-FU].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:11

    Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colectomy; Colonic Neoplasms; Doxorubicin; Drug Administration Routes; Drug Combinations; Fluorouracil; Humans; Injections, Intra-Arterial; Liver Neoplasms; Male; Oxonic Acid; Quality of Life; Remission Induction; Tegafur

2006
[Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma providing a good QOL].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:12

    Topics: Aged; alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Cisplatin; Epirubicin; Fluorouracil; Hepatectomy; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Quality of Life; Tegafur; Tomography, X-Ray Computed; Uracil

2006
[A case of colon cancer liver metastases treated by combined therapies].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Catheter Ablation; Chemotherapy, Adjuvant; Colon, Sigmoid; Combined Modality Therapy; Floxuridine; Fluorouracil; Hepatectomy; Humans; Jaundice, Obstructive; Leucovorin; Liver Neoplasms; Lymph Node Excision; Male; Middle Aged; Sigmoid Neoplasms; Stents; Tegafur

2006
[A case report of advanced gastric cancer with carcinomatous ascites successfully treated by outpatient chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:1

    Topics: Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Ascites; Ascitic Fluid; Cisplatin; Docetaxel; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Male; Middle Aged; Oxonic Acid; Paclitaxel; Peritoneal Neoplasms; Quality of Life; Stomach Neoplasms; Taxoids; Tegafur

2007
Expression of phosphorylated Akt (pAkt) in gastric carcinoma predicts prognosis and efficacy of chemotherapy.
    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2007, Volume: 10, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Female; Fluorouracil; Humans; Male; Middle Aged; Phosphorylation; Predictive Value of Tests; Prognosis; Proto-Oncogene Proteins c-akt; Stomach Neoplasms; Survival Analysis; Tegafur; Tumor Suppressor Protein p53

2007
[A resected case of squamous cell carcinoma of the breast successfully treated by FU plus cisplatin (CDDP) adjuvant therapy against recurrent metastases].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Mastectomy; Neoplasm Invasiveness; Oxonic Acid; Skin Neoplasms; Tegafur; Uracil

2007
[A long survival case of sigmoid colon cancer patient with initially unresectable hepatic metastases].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:4

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Female; Fluorouracil; Hepatectomy; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Middle Aged; Neoadjuvant Therapy; Second-Look Surgery; Sigmoid Neoplasms; Survivors; Tegafur; Uracil

2007
The clinical and economic benefits of capecitabine and tegafur with uracil in metastatic colorectal cancer.
    British journal of cancer, 2007, May-07, Volume: 96, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Tegafur; United Kingdom; Uracil

2007
Peritoneal dissemination of hepatocellular carcinoma treated with a combination therapy of interferon-alpha-2b and oral tegafur/uracil.
    Internal medicine (Tokyo, Japan), 2007, Volume: 46, Issue:9

    Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Fatigue; Fluorouracil; Humans; Injections, Intravenous; Injections, Subcutaneous; Interferon alpha-2; Interferon-alpha; Liver Neoplasms; Male; Nausea; Peritoneal Neoplasms; Recombinant Proteins; Retreatment; Tegafur; Tomography, X-Ray Computed; Treatment Outcome

2007
[Comparison the standard therapies of gastric cancer in Japan with those in the West].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Drug Administration Schedule; Drug Combinations; Europe; Fluorouracil; Gastrectomy; Humans; Japan; Lymph Node Excision; Mitomycin; Neoplasm Staging; Practice Guidelines as Topic; Stomach Neoplasms; Survival Rate; Tegafur; United States; Uracil

2007
[Nedaplatin (NDP)-combination therapy (NDP/5-FU,NDP/S-1) for oral cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:5

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Infusions, Intravenous; Leukopenia; Male; Middle Aged; Mouth Neoplasms; Nausea; Organoplatinum Compounds; Oxonic Acid; Tegafur; Thrombocytopenia; Vomiting, Anticipatory

2007
Expression of orotate phosphoribosyl transferase in human pancreatic cancer: implication for the efficacy of uracil and tegafur-based adjuvant chemotherapy.
    Oncology reports, 2007, Volume: 18, Issue:1

    Topics: Adenocarcinoma, Mucinous; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Pancreatic Ductal; Carcinoma, Papillary; Chemotherapy, Adjuvant; Cyclophosphamide; Deoxycytidine; Female; Fluorouracil; Gemcitabine; Humans; Male; Middle Aged; Neoplasm Staging; Orotate Phosphoribosyltransferase; Pancreatic Neoplasms; Prognosis; Survival Rate; Tegafur

2007
[Pharmacokinetics of 5-FU after S-1 oral administration for adjuvant chemotherapy in gastric cancer patients].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:6

    Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Drug Combinations; Female; Fluorouracil; Gastrectomy; Humans; Male; Middle Aged; Neoplasm Staging; Oxonic Acid; Stomach Neoplasms; Tegafur

2007
[Long survival of a colon cancer case with multiple liver metastases cured by multidisciplinary therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:6

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Catheter Ablation; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Drug Combinations; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Male; Organoplatinum Compounds; Oxonic Acid; Sigmoid Neoplasms; Survivors; Tegafur

2007
[Therapeutic strategy for type 4 gastric cancer from the clinical oncologist standpoint].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:7

    Topics: Adenocarcinoma, Scirrhous; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Irinotecan; Male; Methotrexate; Middle Aged; Oxonic Acid; Paclitaxel; Prognosis; Stomach Neoplasms; Survival Rate; Tegafur

2007
[Evaluation of combination therapy of high-dose toremifene and oral chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:7

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Cyclophosphamide; Deoxycytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Female; Floxuridine; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Lymph Nodes; Lymphatic Metastasis; Middle Aged; Neoplasm Recurrence, Local; Oxonic Acid; Quality of Life; Skin Neoplasms; Tegafur; Toremifene

2007
Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients.
    Journal of neurology, neurosurgery, and psychiatry, 2008, Volume: 79, Issue:5

    Topics: Adult; Aged; Antineoplastic Agents; Brain; Brain Edema; Capecitabine; Dementia, Vascular; Deoxycytidine; Diffusion Magnetic Resonance Imaging; Energy Metabolism; Female; Fluorouracil; Follow-Up Studies; Humans; Image Processing, Computer-Assisted; Infusions, Intravenous; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Neoplasms; Nerve Fibers, Myelinated; Neurologic Examination; Registries; Remission, Spontaneous; Stroke; Tegafur

2008
Alternative pharmacokinetics of S-1 components, 5-fluorouracil, dihydrofluorouracil and alpha-fluoro-beta-alanine after oral administration of S-1 following total gastrectomy.
    Cancer science, 2007, Volume: 98, Issue:10

    Topics: Administration, Oral; Adult; Aged; Area Under Curve; beta-Alanine; Drug Combinations; Fluorouracil; Gastrectomy; Humans; Middle Aged; Oxonic Acid; Stomach Neoplasms; Tegafur

2007
[An elderly case of advanced cervical esophageal cancer successfully treated with UFT after chemoradiotherapy with docetaxel/5-FU/CDDP].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:8

    Topics: Aged, 80 and over; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Docetaxel; Drug Administration Schedule; Drug Combinations; Esophageal Neoplasms; Female; Fluorouracil; Humans; Lung Neoplasms; Lymph Nodes; Lymphatic Metastasis; Quality of Health Care; Taxoids; Tegafur; Uracil

2007
Epidermal growth factor receptor mutation status and adjuvant chemotherapy with uracil-tegafur for adenocarcinoma of the lung.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Sep-01, Volume: 25, Issue:25

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; ErbB Receptors; Female; Fluorouracil; Humans; Lung Neoplasms; Male; Mutation; Retrospective Studies; Survival Rate; Tegafur; Tumor Cells, Cultured; Uracil

2007
[The fourth report from Sapporo Tsukisamu Hospital - chemotherapy and its regimen as second choice for patients with early gastric cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:10

    Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Female; Fluorouracil; Humans; Male; Middle Aged; Retrospective Studies; Stomach Neoplasms; Survival Rate; Tegafur; Uracil

2007
[A case of metastatic rectal cancer showing a sustained complete response to chemotherapy with FOLFIRI followed by UFT].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:10

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Female; Fluorouracil; Humans; Leucovorin; Neoplasm Metastasis; Rectal Neoplasms; Tegafur; Uracil

2007
Synergistic antitumor effect of combined 5-fluorouracil (5-FU) with 5-chloro-2,4-dihydroxypyridine on 5-FU-resistant gastric cancer cells: possible role of a dihydropyrimidine dehydrogenase-independent mechanism.
    Journal of gastroenterology, 2007, Volume: 42, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Drug Combinations; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Oxonic Acid; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stomach Neoplasms; Tegafur; Thymidylate Synthase

2007
A multi-center retrospective analysis of survival benefits of chemotherapy for unresectable biliary tract cancer.
    Japanese journal of clinical oncology, 2007, Volume: 37, Issue:11

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biliary Tract Neoplasms; Cisplatin; Deoxycytidine; Doxorubicin; Drug Combinations; Female; Fluorouracil; Gemcitabine; Humans; Male; Middle Aged; Mitomycin; Oxonic Acid; Proportional Hazards Models; Retrospective Studies; Survival Analysis; Tegafur

2007
Improved determination of 5-fluorouracil and its prodrug tegafur in pharmaceuticals by large-volume sample stacking in CE.
    Journal of separation science, 2007, Volume: 30, Issue:18

    Topics: Electrophoresis, Capillary; Fluorouracil; Molecular Structure; Pharmaceutical Preparations; Prodrugs; Tegafur

2007
[Two cases of stage IV gastric cancer who underwent total gastrectomy and achieved long-term survival by sequential chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:13

    Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Combined Modality Therapy; Drug Combinations; Female; Fluorouracil; Gastrectomy; Humans; Immunosuppressive Agents; Irinotecan; Male; Methotrexate; Middle Aged; Oxonic Acid; Paclitaxel; Stomach Neoplasms; Tegafur

2007
[A case report--combination chemotherapy with oral UFT and CPT-11, 5-FU, l-LV by hepatic arterial infusion for multiple hepatic metastasis from sigmoid colon cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:13

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Female; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Middle Aged; Sigmoid Neoplasms; Tegafur; Uracil

2007
UFT as maintenance therapy in patients with advanced colorectal cancer responsive to the FOLFOX4 regimen.
    Oncology, 2007, Volume: 72, Issue:5-6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease Progression; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Organoplatinum Compounds; Quality of Life; Remission Induction; Tegafur; Uracil

2007
The CYP2A6*4 allele is determinant of S-1 pharmacokinetics in Japanese patients with non-small-cell lung cancer.
    Clinical pharmacology and therapeutics, 2008, Volume: 83, Issue:4

    Topics: Adult; Aged; Alleles; Antimetabolites, Antineoplastic; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Asian People; Carcinoma, Non-Small-Cell Lung; Cytochrome P-450 CYP2A6; Drug Combinations; Female; Fluorouracil; Genotype; Humans; Lung Neoplasms; Male; Middle Aged; Mixed Function Oxygenases; Oxonic Acid; Smoking; Tegafur

2008
Study of carbonyl iron/poly(butylcyanoacrylate) (core/shell) particles as anticancer drug delivery systems Loading and release properties.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2008, Mar-03, Volume: 33, Issue:3

    Topics: Antimetabolites, Antineoplastic; Drug Delivery Systems; Enbucrilate; Fluorouracil; Hydrogen-Ion Concentration; Iron Compounds; Nanoparticles; Tegafur

2008
Oral treatment for gastric cancer: new choices, better choices?
    The Lancet. Oncology, 2008, Volume: 9, Issue:3

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Capecitabine; Clinical Trials, Phase III as Topic; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Japan; Oxonic Acid; Randomized Controlled Trials as Topic; Stomach Neoplasms; Survival Rate; Tegafur

2008
Sustained release of antineoplastic drugs from chitosan-reinforced alginate microparticle drug delivery systems.
    International journal of pharmaceutics, 2008, Jun-05, Volume: 357, Issue:1-2

    Topics: Alginates; Antimetabolites, Antineoplastic; Antineoplastic Agents; Chemical Phenomena; Chemistry, Physical; Chitosan; Delayed-Action Preparations; Drug Compounding; Drug Delivery Systems; Excipients; Fluorouracil; Microscopy, Electron, Scanning; Nanoparticles; Particle Size; Polysaccharides; Tegafur

2008
The unanswered question: what is the determinant of S-1 pharmacokinetics?
    Clinical pharmacology and therapeutics, 2008, Volume: 84, Issue:2

    Topics: Alleles; Antimetabolites, Antineoplastic; Aryl Hydrocarbon Hydroxylases; Asian People; Body Size; Carcinoma, Non-Small-Cell Lung; Cytochrome P-450 CYP2A6; Drug Combinations; Fluorouracil; Humans; Lung Neoplasms; Oxonic Acid; Tegafur

2008
[Complete response in a case of advanced esophageal cancer treated with docetaxel/5-FU/CDDPand S-1/docetaxel as neoadjuvant chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2008, Volume: 35, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Docetaxel; Drug Combinations; Esophageal Neoplasms; Female; Fluorouracil; Gastroscopy; Humans; Middle Aged; Neoadjuvant Therapy; Oxonic Acid; Taxoids; Tegafur; Tomography, X-Ray Computed

2008
Anti-angiogenic effect of 5-Fluorouracil-based drugs against human colon cancer xenografts.
    Cancer letters, 2008, Aug-18, Volume: 267, Issue:1

    Topics: Angiogenesis Inhibitors; Animals; Capecitabine; Colonic Neoplasms; Deoxycytidine; Drug Combinations; Fluorouracil; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Oxonic Acid; Tegafur; Thrombospondin 1; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

2008
5-Fluorouracil incorporated into the tissue RNA of human and rat bladder carcinoma after administration of 1-(2-tetrahydrofuryl)-5-fluorouracil combined with uracil.
    International journal of clinical oncology, 2008, Volume: 13, Issue:2

    Topics: Aged; Aged, 80 and over; Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Rats; Rats, Inbred F344; RNA, Neoplasm; Tegafur; Uracil; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays

2008
[A case of advanced gastric cancer with peritoneal metastasis successfully treated over 19 months with postoperative chemotherapy after non-curative surgery].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2008, Volume: 35, Issue:5

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Combinations; Female; Fluorouracil; Gastrectomy; Humans; Irinotecan; Methotrexate; Oxonic Acid; Paclitaxel; Peritoneal Neoplasms; Stomach Neoplasms; Tegafur

2008
Effects of combined administration of DPD-inhibitory oral fluoropyrimidine, S-1, plus paclitaxel on gene expressions of fluoropyrimidine metabolism-related enzymes in human gastric xenografts.
    Annals of surgical oncology, 2008, Volume: 15, Issue:8

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Drug Synergism; Drug Therapy, Combination; Female; Fluorouracil; Gene Expression; Humans; Male; Mice; Mice, Inbred BALB C; Orotate Phosphoribosyltransferase; Oxonic Acid; Paclitaxel; Stomach Neoplasms; Tegafur; Thymidine Phosphorylase; Thymidylate Synthase; Uridine Phosphorylase; Xenograft Model Antitumor Assays

2008
Additive effects of oral fluoropyrimidine derivative S-1 and radiation on human hypopharyngeal cancer xenografts.
    Acta oto-laryngologica, 2008, Volume: 128, Issue:8

    Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Combined Modality Therapy; Drug Combinations; Fluorouracil; Humans; Hypopharyngeal Neoplasms; Male; Mice; Mice, Nude; Oxonic Acid; Tegafur; Tumor Burden; Xenograft Model Antitumor Assays

2008
Is there an optimal chemotherapy regimen for the treatment of advanced gastric cancer that will provide a platform for the introduction of new biological agents?
    The oncologist, 2008, Volume: 13, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Clinical Trials, Phase III as Topic; Deoxycytidine; Docetaxel; Drug Combinations; Fluorouracil; Humans; Immunologic Factors; Irinotecan; Meta-Analysis as Topic; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Randomized Controlled Trials as Topic; Stomach Neoplasms; Taxoids; Tegafur

2008
[Case of gastric cancer with isolated brain metastasis successfully managed by gamma knife radiotherapy and chemotherapy].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2008, Volume: 105, Issue:8

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Combined Modality Therapy; Drug Combinations; Fluorouracil; Humans; Male; Middle Aged; Oxonic Acid; Radiosurgery; Stomach Neoplasms; Tegafur; Treatment Outcome

2008
Immunochemotherapy with PSK and fluoropyrimidines improves long-term prognosis for curatively resected colorectal cancer.
    Cancer biotherapy & radiopharmaceuticals, 2008, Volume: 23, Issue:4

    Topics: Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Combined Modality Therapy; Drug Combinations; Female; Floxuridine; Fluorouracil; Humans; Immunotherapy; Kaplan-Meier Estimate; Male; Middle Aged; Prognosis; Proportional Hazards Models; Proteoglycans; Retrospective Studies; Tegafur; Uracil

2008
Efficacy of S-1 in heavily pretreated patients with metastatic breast cancer: cross-resistance to capecitabine.
    Breast cancer (Tokyo, Japan), 2009, Volume: 16, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Anthracyclines; Antimetabolites, Antineoplastic; Bone Neoplasms; Breast Neoplasms; Bridged-Ring Compounds; Capecitabine; Deoxycytidine; Drug Combinations; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Oxonic Acid; Pleural Neoplasms; Prognosis; Retrospective Studies; Survival Rate; Taxoids; Tegafur; Treatment Outcome

2009
[Two cases of squamous cell carcinoma of upper urinary tract with hypercalcemia].
    Nihon Hinyokika Gakkai zasshi. The japanese journal of urology, 2008, Volume: 99, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Fatal Outcome; Female; Fluorouracil; Granulocyte Colony-Stimulating Factor; Humans; Hypercalcemia; Kidney Neoplasms; Kidney Pelvis; Male; Middle Aged; Neoplasm Recurrence, Local; Parathyroid Hormone-Related Protein; Radiotherapy; Tegafur; Uracil; Ureteral Neoplasms

2008
Oral fluoropyrimidines (capecitabine or S-1) and cisplatin as first line treatment in elderly patients with advanced gastric cancer: a retrospective study.
    Japanese journal of clinical oncology, 2009, Volume: 39, Issue:1

    Topics: Adenocarcinoma; Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cisplatin; Combined Modality Therapy; Deoxycytidine; Drug Combinations; Female; Fluorouracil; Follow-Up Studies; Humans; Male; Maximum Tolerated Dose; Neoplasm Recurrence, Local; Neoplasm Staging; Oxonic Acid; Prognosis; Retrospective Studies; Stomach Neoplasms; Tegafur

2009
[A case of metastatic lung and liver tumors from rectal cancer treated with oral UFT and CPT-11 by hepatic arterial infusion followed by FOLFOX and FOLFIRI].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2008, Volume: 35, Issue:11

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Camptothecin; Fluorouracil; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Rectal Neoplasms; Tegafur; Tomography, X-Ray Computed; Uracil

2008
Relationships of insulin-like growth factor-1 receptor and epidermal growth factor receptor expression to clinical outcomes in patients with colorectal cancer.
    Oncology, 2009, Volume: 76, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Colonic Neoplasms; Colorectal Neoplasms; ErbB Receptors; Female; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Male; Middle Aged; Prognosis; Receptor, IGF Type 1; Rectal Neoplasms; Tegafur; Treatment Outcome

2009
Development history and concept of an oral anticancer agent S-1 (TS-1): its clinical usefulness and future vistas.
    Japanese journal of clinical oncology, 2009, Volume: 39, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Drug Combinations; Fluorouracil; History, 20th Century; History, 21st Century; Humans; Neoplasms; Oxonic Acid; Tegafur

2009
Gemcitabine-based versus fluoropyrimidine-based chemotherapy with or without platinum in unresectable biliary tract cancer: a retrospective study.
    BMC cancer, 2008, Dec-18, Volume: 8

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biliary Tract Neoplasms; Capecitabine; Cisplatin; Deoxycytidine; Drug Combinations; Female; Fluorouracil; Gemcitabine; Humans; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Palliative Care; Pyrimidinones; Retrospective Studies; Tegafur; Treatment Outcome; Uracil

2008
Comparison of alternate-day versus consecutive-day treatment with S-1: assessment of tumor growth inhibition and toxicity reduction in gastric cancer cell lines in vitro and in vivo.
    International journal of clinical oncology, 2008, Volume: 13, Issue:6

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Bone Marrow Diseases; Cell Proliferation; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Gastrointestinal Tract; Humans; In Vitro Techniques; Mice; Mice, Inbred BALB C; Mice, Nude; Oxonic Acid; Stomach Neoplasms; Survival Rate; Tegafur; Tetrazolium Salts; Tumor Cells, Cultured

2008
Successful treatment of advanced gallbladder cancer with an anticancer drug S-1: assessment based on intratumoral gene.
    International journal of clinical oncology, 2008, Volume: 13, Issue:6

    Topics: Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Female; Fluorouracil; Gallbladder Neoplasms; Humans; Middle Aged; Oxonic Acid; Tegafur; Tomography, X-Ray Computed

2008
The efficacy and safety of concurrent chemoradiotherapy for maxillary sinus squamous cell carcinoma patients.
    Auris, nasus, larynx, 2009, Volume: 36, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Female; Fluorouracil; Humans; Kaplan-Meier Estimate; Leucovorin; Male; Maxillary Sinus; Methotrexate; Middle Aged; Neoadjuvant Therapy; Organ Preservation; Paranasal Sinus Neoplasms; Retrospective Studies; Tegafur; Treatment Outcome; Uracil

2009
[Our experiences of preoperative chemo-radiotherapy for T4 primary rectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2008, Volume: 35, Issue:12

    Topics: Antineoplastic Agents; Drug Combinations; Fluorouracil; Humans; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Oxonic Acid; Rectal Neoplasms; Tegafur

2008
[Complete response of advanced rectal cancer with combined therapy of S-1 + chemo-radiation plus FOLFIRI--a case report].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2008, Volume: 35, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Camptothecin; Drug Combinations; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Staging; Oxonic Acid; Proctoscopy; Rectal Neoplasms; Remission Induction; Tegafur; Tomography, X-Ray Computed

2008
Laparoscopic resection of extraperitoneal rectal cancer: a comparative analysis with open resection.
    Surgical endoscopy, 2009, Volume: 23, Issue:8

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Combined Modality Therapy; Disease Progression; Disease-Free Survival; Elective Surgical Procedures; Female; Fluorouracil; Follow-Up Studies; Humans; Laparoscopy; Laparotomy; Levamisole; Male; Middle Aged; Neoplasm Invasiveness; Postoperative Complications; Prospective Studies; Radiotherapy, Adjuvant; Rectal Neoplasms; Tegafur; Treatment Outcome

2009
Addition of S-1 to the epidermal growth factor receptor inhibitor gefitinib overcomes gefitinib resistance in non-small cell lung cancer cell lines with MET amplification.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Feb-01, Volume: 15, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Drug Combinations; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; E2F1 Transcription Factor; ErbB Receptors; Fluorouracil; Gefitinib; Gene Amplification; Genes, erbB-1; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Mutation; Oxonic Acid; Proto-Oncogene Mas; Proto-Oncogene Proteins c-met; Quinazolines; Tegafur; Thymidylate Synthase

2009
Pharmacokinetic study of S-1.
    International journal of clinical pharmacology and therapeutics, 2009, Volume: 47, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Anti-Ulcer Agents; Antimetabolites, Antineoplastic; Area Under Curve; beta-Alanine; Biological Availability; Clinical Trials as Topic; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Fasting; Fluorouracil; Food; Gastric Acidity Determination; Half-Life; Humans; Hydrogen-Ion Concentration; Oxonic Acid; Pantoprazole; Pyridines; Tegafur; Triazines; Uracil

2009
Activity of S-1 in advanced or recurrent gastric cancer patients after failure of prior chemotherapy, including irinotecan + cisplatin or fluorouracil (except S-1).
    Japanese journal of clinical oncology, 2009, Volume: 39, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Drug Combinations; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Irinotecan; Male; Middle Aged; Neoplasm Recurrence, Local; Oxonic Acid; Retrospective Studies; Stomach Neoplasms; Tegafur

2009
Experimental study of combination therapy with S-1 against pancreatic cancer.
    Cancer chemotherapy and pharmacology, 2009, Volume: 64, Issue:6

    Topics: Animals; Antineoplastic Agents; Apoptosis; Camptothecin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cisplatin; Deoxycytidine; Doxorubicin; Drug Combinations; Drug Synergism; Drug Therapy, Combination; Female; Fluorouracil; Gemcitabine; Humans; Inhibitory Concentration 50; Irinotecan; Mice; Mice, Inbred BALB C; Mitomycin; Oxonic Acid; Paclitaxel; Pancreatic Neoplasms; Pyridines; Tegafur; Xenograft Model Antitumor Assays

2009
Pharmacokinetics of 5-fluorouracil in elderly Japanese patients with cancer treated with S-1 (a combination of tegafur and dihydropyrimidine dehydrogenase inhibitor 5-chloro-2,4-dihydroxypyridine).
    Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:7

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Asian People; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Fluorouracil; Humans; Metabolic Clearance Rate; Neoplasms; Pyridines; Tegafur

2009
Effects of oral administration of S-1 on the pharmacokinetics of SN-38, irinotecan active metabolite, in patients with advanced colorectal cancer.
    Therapeutic drug monitoring, 2009, Volume: 31, Issue:3

    Topics: Administration, Oral; Aged; Antineoplastic Agents, Phytogenic; Camptothecin; Colorectal Neoplasms; Drug Combinations; Female; Fluorouracil; Humans; Irinotecan; Male; Middle Aged; Oxonic Acid; Prodrugs; Tegafur

2009
A micro cell culture analog (microCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs.
    Lab on a chip, 2009, May-21, Volume: 9, Issue:10

    Topics: Antimetabolites, Antineoplastic; Cell Culture Techniques; Cell Line; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Equipment Design; Fluorouracil; Granulocyte Precursor Cells; HCT116 Cells; Humans; Hydrogels; Liver; Microfluidic Analytical Techniques; Reproducibility of Results; Tegafur

2009
Vascular endothelial growth factor receptor expression as a prognostic marker for survival in colorectal cancer.
    Japanese journal of clinical oncology, 2009, Volume: 39, Issue:9

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Combinations; Female; Fluorouracil; Humans; Immunoenzyme Techniques; Leucovorin; Male; Middle Aged; Neoplasm Staging; Oxonic Acid; Prognosis; Retrospective Studies; Survival Rate; Tegafur; Uracil; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factor Receptor-3

2009
Postoperative chemotherapy after neoadjuvant chemoradiation and surgery for rectal cancer: is it essential for patients with ypT0-2N0?
    Journal of surgical oncology, 2009, Oct-01, Volume: 100, Issue:5

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Humans; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Rectal Neoplasms; Retrospective Studies; Tegafur; Uracil

2009
[Impact of adjuvant chemotherapy duration on 3-year disease-free survival of colorectal carcinoma patients after radical resection].
    Ai zheng = Aizheng = Chinese journal of cancer, 2009, Volume: 28, Issue:7

    Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Carcinoma, Signet Ring Cell; Chemotherapy, Adjuvant; Colorectal Neoplasms; Deoxycytidine; Disease-Free Survival; Female; Fluorouracil; Follow-Up Studies; Humans; Leucovorin; Lymphatic Metastasis; Male; Middle Aged; Multivariate Analysis; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Sex Factors; Tegafur

2009
The effect of neoadjuvant therapy on the 5-fluorouracil metabolic and relative enzymes of oral squamous cell carcinoma.
    Oncology reports, 2009, Volume: 22, Issue:3

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Humans; Male; Middle Aged; Mouth Neoplasms; Neoadjuvant Therapy; Orotate Phosphoribosyltransferase; Tegafur; Thymidine Phosphorylase; Thymidylate Synthase; Uracil

2009
Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy.
    Annals of surgical oncology, 2009, Volume: 16, Issue:12

    Topics: AC133 Antigen; Adult; Aged; Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Colonic Neoplasms; Combined Modality Therapy; Female; Fluorouracil; Glycoproteins; Humans; Immunoenzyme Techniques; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm, Residual; Octamer Transcription Factor-3; Peptides; Prognosis; Radiotherapy Dosage; Rectal Neoplasms; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; SOXB1 Transcription Factors; Survival Rate; Tegafur; Tumor Cells, Cultured; Uracil

2009
The necessity of chemotherapy in T3N0M0 colon cancer without risk factors.
    American journal of surgery, 2009, Volume: 198, Issue:3

    Topics: Adult; Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colonic Neoplasms; Combined Modality Therapy; Deoxycytidine; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Proportional Hazards Models; Retrospective Studies; Risk Factors; Survival Rate; Tegafur; Treatment Outcome; Uracil

2009
[A case of simultaneous bilateral metastatic ovarian tumor of colon cancer followed by FOLFOX4 Regimen and oral tegafur/uracil+oral leucovorin after R0 operation].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:9

    Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colectomy; Colonic Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Organoplatinum Compounds; Ovarian Neoplasms; Tegafur; Uracil; Vitamin B Complex

2009
Treatment of gastric cancer in Asia: the missing link.
    The Lancet. Oncology, 2009, Volume: 10, Issue:11

    Topics: Adenocarcinoma; Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Disease-Free Survival; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Infusions, Intravenous; Irinotecan; Japan; Oxonic Acid; Patient Selection; Risk Assessment; Stomach Neoplasms; Tegafur; Time Factors; Treatment Outcome

2009
[Complete remission with FLEP chemotherapy for multiple liver metastasis from alpha-fetoprotein-producing gastric cancer--report of a case].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:11

    Topics: Adenocarcinoma; alpha-Fetoproteins; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Drug Combinations; Etoposide; Fluorouracil; Gastrectomy; Humans; Immunohistochemistry; Leucovorin; Liver Neoplasms; Male; Middle Aged; Oxonic Acid; Remission Induction; Stomach Neoplasms; Tegafur

2009
Effect of dimethylnitrosamine-induced liver dysfunction on the pharmacokinetics of 5-fluorouracil after administration of S-1, an antitumour drug, to rats.
    The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:12

    Topics: Animals; Antineoplastic Agents; Area Under Curve; Chemical and Drug Induced Liver Injury; Dihydrouracil Dehydrogenase (NADP); Dimethylnitrosamine; Drug Combinations; Fluorouracil; Kidney; Liver; Liver Diseases; Male; Oxonic Acid; Rats; Rats, Sprague-Dawley; Tegafur

2009
A retrospective comparison of concurrent 5-fluorouracil or oral UFT in postoperative chemoradiation for gastric adenocarcinoma.
    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique, 2010, Volume: 14, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Fluorouracil; Gastrectomy; Humans; Male; Middle Aged; Radiotherapy, Adjuvant; Retrospective Studies; Stomach Neoplasms; Tegafur; Uracil

2010
[A Case of gastric endocrine cell carcinoma successfully treated by FU plus irinotecan(CPT-11)adjuvant therapy against recurrent metastases].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:13

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Fluorouracil; Gastrectomy; Humans; Irinotecan; Lymph Node Excision; Male; Neoplasm Metastasis; Stomach Neoplasms; Tegafur; Uracil

2009
[Assessment of chemoradiation therapy for advanced rectal cancer invaded the pelvic organ].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:12

    Topics: Adenocarcinoma, Mucinous; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Combined Modality Therapy; Drug Combinations; Female; Fluorouracil; Humans; Male; Oxonic Acid; Pelvis; Rectal Neoplasms; Tegafur

2009
[A case of advanced right colonic cancer successfully treated by surgery and post operative chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:12

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colonic Neoplasms; Combined Modality Therapy; Drug Combinations; Fluorouracil; Humans; Irinotecan; Leucovorin; Lymph Node Excision; Lymphatic Metastasis; Male; Middle Aged; Organoplatinum Compounds; Oxonic Acid; Postoperative Period; Tegafur

2009
[A case of long-term survival of unresectable-advanced gastric cancer due to chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:12

    Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Drug Combinations; Fluorouracil; Humans; Irinotecan; Male; Middle Aged; Oxonic Acid; Stomach Neoplasms; Tegafur

2009
[A case of successful multimodal treatment for combined hepatocellular and cholangiocarcinoma with portal venous tumor thrombus].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:12

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellular; Cholangiocarcinoma; Combined Modality Therapy; Drug Combinations; Fluorouracil; Hepatectomy; Humans; Interferons; Liver Neoplasms; Male; Neoplastic Cells, Circulating; Oxonic Acid; Tegafur

2009
[A case of stage IV breast cancer responding to S-1 therapy after FEC and PTX therapies].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:12

    Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Ductal; Cyclophosphamide; Drug Combinations; Epirubicin; Female; Fluorouracil; Humans; Oxonic Acid; Paclitaxel; Pentoxifylline; Quality of Life; Tegafur; Treatment Outcome

2009
Safety, efficacy and pharmacokinetics of S-1 in a hemodialysis patient with advanced gastric cancer.
    Cancer chemotherapy and pharmacology, 2010, Volume: 65, Issue:4

    Topics: Aged; Antimetabolites, Antineoplastic; Area Under Curve; Drug Combinations; Fluorouracil; Humans; Male; Oxonic Acid; Renal Dialysis; Stomach Neoplasms; Tegafur; Treatment Outcome

2010
[Liver metastasis from sigmoid colon cancer showed a complete response to S-1 after recurrence with FOLFOX6 treatment].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:1

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Combinations; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Middle Aged; Neoplasm Recurrence, Local; Oxonic Acid; Sigmoid Neoplasms; Tegafur

2010
Determination of tegafur, 5-fluorouracil, gimeracil and oxonic acid in human plasma using liquid chromatography-tandem mass spectrometry.
    Journal of pharmaceutical and biomedical analysis, 2010, Aug-01, Volume: 52, Issue:4

    Topics: Chromatography, Liquid; Fluorouracil; Humans; Oxonic Acid; Pyridines; Reproducibility of Results; Tandem Mass Spectrometry; Tegafur

2010
Plasma pharmacokinetics after combined therapy of gemcitabine and oral S-1 for unresectable pancreatic cancer.
    Journal of experimental & clinical cancer research : CR, 2010, Feb-24, Volume: 29

    Topics: Administration, Oral; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Drug Combinations; Drug Interactions; Fluorouracil; Gemcitabine; Humans; Mice; Mice, Nude; Middle Aged; Oxonic Acid; Pancreatic Neoplasms; Tegafur; Treatment Outcome; Xenograft Model Antitumor Assays

2010
[A case of colon cancer with multiple liver metastases responding ot S-1 as third-line treatment following FOLFIRI and FOLFOX].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:2

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Camptothecin; Carcinoembryonic Antigen; Colonic Neoplasms; Drug Combinations; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Male; Organoplatinum Compounds; Oxonic Acid; Salvage Therapy; Tegafur; Tomography, X-Ray Computed

2010
Histone deacetylase inhibitor enhances sensitivity of non-small-cell lung cancer cells to 5-FU/S-1 via down-regulation of thymidylate synthase expression and up-regulation of p21(waf1/cip1) expression.
    Cancer science, 2010, Volume: 101, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Drug Combinations; E2F1 Transcription Factor; Fluorouracil; Gene Expression Regulation; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lung Neoplasms; Oxonic Acid; Retinoblastoma Protein; RNA, Messenger; Tegafur; Thymidylate Synthase; Vorinostat

2010
Synergistic antitumor effect of S-1 and HER2-targeting agents in gastric cancer with HER2 amplification.
    Molecular cancer therapeutics, 2010, Volume: 9, Issue:5

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Drug Combinations; Drug Delivery Systems; Drug Synergism; Fluorouracil; Gene Amplification; Humans; Lapatinib; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Oxonic Acid; Quinazolines; Receptor, ErbB-2; Stomach Neoplasms; Tegafur; Trastuzumab; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2010
Formation pathways of gamma-butyrolactone from the furan ring of tegafur during its conversion to 5-fluorouracil.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:8

    Topics: 4-Butyrolactone; Aldehydes; Aryl Hydrocarbon Hydroxylases; Butanols; Cytochrome P-450 CYP2A6; Cytosol; DNA, Complementary; Fluorouracil; Furans; Humans; Liver; Microsomes, Liver; Phenylhydrazines; Sodium Oxybate; Tegafur; Thymidine Phosphorylase

2010
Characterization of a novel lymph node metastasis model from human colonic cancer and its preclinical use for comparison of anti-metastatic efficacy between oral S-1 and UFT/ LV.
    Cancer science, 2010, Volume: 101, Issue:8

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Colonic Neoplasms; Drug Combinations; Drug Evaluation, Preclinical; Fluorouracil; Humans; Leucovorin; Lymphatic Metastasis; Male; Mice; Middle Aged; Oxonic Acid; Tegafur; Uracil; Xenograft Model Antitumor Assays

2010
Circulating lymphocyte number has a positive association with tumor response in neoadjuvant chemoradiotherapy for advanced rectal cancer.
    Radiation oncology (London, England), 2010, Jun-03, Volume: 5

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Combined Modality Therapy; Drug Combinations; Female; Fluorouracil; Follow-Up Studies; Humans; Leucovorin; Lymphocyte Count; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Oxonic Acid; Radiotherapy, Adjuvant; Rectal Neoplasms; Retrospective Studies; Survival Rate; Tegafur; Treatment Outcome; Uracil

2010
Enhanced anticancer effect of the combination of BIBW2992 and thymidylate synthase-targeted agents in non-small cell lung cancer with the T790M mutation of epidermal growth factor receptor.
    Molecular cancer therapeutics, 2010, Volume: 9, Issue:6

    Topics: Afatinib; Amino Acid Substitution; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Drug Combinations; Drug Resistance, Neoplasm; Drug Synergism; E2F1 Transcription Factor; ErbB Receptors; Fluorouracil; Gefitinib; Glutamates; Guanine; Humans; Lung Neoplasms; Mice; Mutation; Oxonic Acid; Pemetrexed; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Mas; Quinazolines; Tegafur; Thymidylate Synthase; Xenograft Model Antitumor Assays

2010
A quantitative evaluation of the determinant proteins for S-1 responsiveness in a biopsy specimen assists in patient selection to neoadjuvant therapy in cases of advanced gastric cancer.
    International journal of oncology, 2010, Volume: 37, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Pharmacological; Biomarkers, Tumor; Biopsy; Carcinoma; Disease Progression; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Neoadjuvant Therapy; Oxonic Acid; Patient Selection; Predictive Value of Tests; Prognosis; Retrospective Studies; Specimen Handling; Stomach Neoplasms; Tegafur

2010
PharmGKB summary: fluoropyrimidine pathways.
    Pharmacogenetics and genomics, 2011, Volume: 21, Issue:4

    Topics: Antimetabolites, Antineoplastic; Capecitabine; Databases, Factual; Deoxycytidine; Fluorouracil; Genome, Human; Humans; Pharmacogenetics; Tegafur

2011
Effects of lentinan alone and in combination with fluoropyrimidine anticancer agent on growth of human oral squamous cell carcinoma in vitro and in vivo.
    International journal of oncology, 2010, Volume: 37, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cell Line, Tumor; Drug Combinations; Female; Fluorouracil; Humans; Lentinan; Mice; Mice, Nude; Mouth Neoplasms; Oxonic Acid; Tegafur; Xenograft Model Antitumor Assays

2010
Clinical results of definitive chemoradiotherapy for patients with synchronous head and neck squamous cell carcinoma and esophageal cancer.
    American journal of clinical oncology, 2011, Volume: 34, Issue:4

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; Carcinoma, Squamous Cell; Cisplatin; Cohort Studies; Combined Modality Therapy; Esophageal Neoplasms; Female; Fluorouracil; Follow-Up Studies; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Neoplasms, Multiple Primary; Oxonic Acid; Pyridines; Remission Induction; Retrospective Studies; Survival Rate; Tegafur; Treatment Outcome

2011
[Effect of pylorus-preserving pancreaticoduodenectomy on serum levels of 5-fluorouracil during S-1 treatment for pancreaticobiliary malignancy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:8

    Topics: Aged; Antimetabolites, Antineoplastic; Biliary Tract Neoplasms; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Oxonic Acid; Pancreatic Neoplasms; Pancreaticoduodenectomy; Tegafur

2010
Oral fluoropyrimidine may augment the efficacy of aromatase inhibitor via the down-regulation of estrogen receptor in estrogen-responsive breast cancer xenografts.
    Breast cancer research and treatment, 2011, Volume: 128, Issue:2

    Topics: Anastrozole; Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Blotting, Western; Breast Neoplasms; Cell Proliferation; Doxorubicin; Drug Combinations; Estrogen Receptor alpha; Estrogens; Female; Fluorouracil; Humans; Immunoenzyme Techniques; Mice; Mice, Inbred BALB C; Mice, Nude; Nitriles; Oxonic Acid; Paclitaxel; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tegafur; Transplantation, Heterologous; Triazoles; Tumor Cells, Cultured; Uracil

2011
Irinotecan overcomes the resistance to 5-fluorouracil in human colon cancer xenografts by down-regulation of intratumoral thymidylate synthase.
    Oncology reports, 2010, Volume: 24, Issue:4

    Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Camptothecin; Colonic Neoplasms; Down-Regulation; Drug Combinations; Drug Resistance, Neoplasm; Fluorouracil; Humans; Irinotecan; Mice; Mice, Nude; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Prodrugs; Tegafur; Thymidylate Synthase; Xenograft Model Antitumor Assays

2010
S-1 for advanced colorectal cancer: do we need another oral fluorouracil prodrug?
    The Lancet. Oncology, 2010, Volume: 11, Issue:9

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Combinations; Fluorouracil; Humans; Oxonic Acid; Prodrugs; Randomized Controlled Trials as Topic; Tegafur

2010
A predictive factor for the response to S-1 plus cisplatin in gastric cancer.
    World journal of gastroenterology, 2010, Sep-28, Volume: 16, Issue:36

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Cisplatin; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Orotate Phosphoribosyltransferase; Oxonic Acid; Stomach Neoplasms; Tegafur; Thymidylate Synthase

2010
Gimeracil, a component of S-1, may enhance the antitumor activity of X-ray irradiation in human cancer xenograft models in vivo.
    Oncology reports, 2010, Volume: 24, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Combined Modality Therapy; Drug Combinations; Fluorouracil; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Oxonic Acid; Pyridines; Radiation-Sensitizing Agents; Tegafur; Whole-Body Irradiation; Xenograft Model Antitumor Assays

2010
Efficacy of S-1 in patients with capecitabine-resistant breast cancer-Japan Breast Cancer Research Network (JBCRN) 04-1 trial.
    Anticancer research, 2010, Volume: 30, Issue:9

    Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Capecitabine; Deoxycytidine; Disease-Free Survival; Drug Combinations; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Middle Aged; Neoplasm Metastasis; Oxonic Acid; Retrospective Studies; Salvage Therapy; Tegafur; Treatment Outcome

2010
Effect of S-1 adjuvant chemotherapy on survival following recurrence and efficacy of first-line treatment in recurrent gastric cancer.
    Chemotherapy, 2010, Volume: 56, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Disease-Free Survival; Drug Combinations; Female; Fluorouracil; Gastrectomy; Humans; Male; Middle Aged; Neoplasm Staging; Oxonic Acid; Recurrence; Retrospective Studies; Stomach Neoplasms; Tegafur; Treatment Outcome

2010
Chemosensitivity test for 5-fluorouracil and 5-chloro-2, 4-dihydroxypyridine predicts outcome of gastric cancer patients receiving S-1 postoperatively.
    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2010, Volume: 13, Issue:4

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Drug Combinations; Female; Fluorouracil; Follow-Up Studies; Humans; Male; Neoplasm Recurrence, Local; Neoplasm Staging; Oxonic Acid; Postoperative Care; Predictive Value of Tests; Pyridines; Stomach Neoplasms; Survival Analysis; Tegafur; Treatment Outcome

2010
Standard-dose tegafur combined with uracil is not safe treatment after severe toxicity from 5-fluorouracil or capecitabine.
    Annals of internal medicine, 2010, Dec-07, Volume: 153, Issue:11

    Topics: Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Humans; Prodrugs; Rectal Neoplasms; Tegafur

2010
[A case of capecitabine-resistant recurrent breast cancer found to be responsive to S-1].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:13

    Topics: Breast Neoplasms; Capecitabine; Deoxycytidine; Drug Combinations; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Middle Aged; Neoplasm Recurrence, Local; Oxonic Acid; Tegafur

2010
Combined therapy with a thymidylate synthase-inhibiting vector and S-1 has effective antitumor activity against 5-FU-resistant tumors.
    International journal of oncology, 2011, Volume: 38, Issue:2

    Topics: Adenoviridae; Animals; Antimetabolites, Antineoplastic; Apoptosis; Blotting, Western; Cell Proliferation; Colorectal Neoplasms; Combined Modality Therapy; Drug Combinations; Drug Resistance, Neoplasm; Drug Synergism; Fluorouracil; Genetic Therapy; Genetic Vectors; Humans; Male; Mice; Mice, Nude; Oxonic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Survival Rate; Tegafur; Thymidylate Synthase; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2011
Combined chemoradiotherapy for early glottic cancer in clinical practice in Japan: analysis of 10 institutions.
    Anticancer research, 2010, Volume: 30, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cisplatin; Combined Modality Therapy; Dose Fractionation, Radiation; Female; Fluorouracil; Glottis; Humans; Japan; Laryngeal Neoplasms; Male; Middle Aged; Tegafur; Uracil

2010
[Long-term control of sacral metastasis from rectal cancer with S-1 + radiation treatment (RT) and mFOLFOX6 combination therapy--a case report].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:12

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Combined Modality Therapy; Drug Combinations; Fluorouracil; Humans; Leucovorin; Male; Organoplatinum Compounds; Oxonic Acid; Radiotherapy Dosage; Rectal Neoplasms; Sacrum; Tegafur

2010
[A long-term survival case of rectal cancer with Virchow's lymph node metastasis by multimodality therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:12

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Combined Modality Therapy; Fluorouracil; Humans; Irinotecan; Leucovorin; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Organoplatinum Compounds; Rectal Neoplasms; Tegafur; Uracil

2010
[A case of recurrent sigmoid colon cancer with adrenal and para-aortic lymph node metastasis successfully treated by operation and chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:12

    Topics: Adrenal Gland Neoplasms; Adrenalectomy; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Aorta; Bevacizumab; Camptothecin; Combined Modality Therapy; Female; Fluorouracil; Hepatectomy; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Lymphatic Metastasis; Middle Aged; Neoplasm Recurrence, Local; Organoplatinum Compounds; Sigmoid Neoplasms; Tegafur; Uracil

2010
[A case of unresectable multiple hepatic metastases from colorectal cancer successfully treated with IRIS (S-1, CPT-11) therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:12

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Drug Combinations; Fluorouracil; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Male; Oxonic Acid; Tegafur; Tumor Burden

2010
[A long-term disease-free survival case of advanced rectal cancer with massive metastasis to the lateral pelvic and para-aortic lymph nodes].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:12

    Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Aorta, Abdominal; Camptothecin; Combined Modality Therapy; Disease-Free Survival; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Irinotecan; Leucovorin; Lymph Node Excision; Lymphatic Metastasis; Male; Oxonic Acid; Pelvis; Rectal Neoplasms; Tegafur; Vitamin B Complex

2010
[A case report of primary adenocarcinoma of small intestine].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:12

    Topics: Adenocarcinoma; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Combined Modality Therapy; Drug Combinations; Female; Fluorouracil; Humans; Ileal Neoplasms; Intestinal Neoplasms; Leucovorin; Lymphatic Metastasis; Middle Aged; Organoplatinum Compounds; Ovarian Neoplasms; Oxonic Acid; Tegafur

2010
Retrospective cohort study on the safety and efficacy of bevacizumab with chemotherapy for metastatic colorectal cancer patients: the HGCSG0801 study.
    Japanese journal of clinical oncology, 2011, Volume: 41, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Cohort Studies; Colorectal Neoplasms; Confidence Intervals; Disease-Free Survival; Drug Administration Schedule; Drug Combinations; Epistaxis; Female; Fluorouracil; Gastrointestinal Hemorrhage; Humans; Hypertension; Irinotecan; Japan; Kaplan-Meier Estimate; Leucovorin; Liver Neoplasms; Male; Middle Aged; Neoplasm Staging; Organoplatinum Compounds; Oxonic Acid; Proteinuria; Retrospective Studies; Tegafur; Thrombosis; Treatment Outcome

2011
Low-dose docetaxel enhances the sensitivity of S-1 in a xenograft model of human castration resistant prostate cancer.
    International journal of cancer, 2012, Jan-15, Volume: 130, Issue:2

    Topics: Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Docetaxel; Drug Combinations; Drug Synergism; Fluorouracil; Humans; Ki-67 Antigen; Male; Mice; Mice, SCID; Oxonic Acid; Prostatectomy; Prostatic Neoplasms; Taxoids; Tegafur; Thymidylate Synthase; Xenograft Model Antitumor Assays

2012
[A case of multiple para-aortic lymph node metastases from squamous cell carcinoma of an unknown primary responding completely to chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2011, Volume: 38, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Aorta; Carcinoma, Squamous Cell; Cisplatin; Drug Combinations; Fluorouracil; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasms, Unknown Primary; Oxonic Acid; Positron-Emission Tomography; Remission Induction; Tegafur; Tomography, X-Ray Computed

2011
Metronomic S-1 chemotherapy and vandetanib: an efficacious and nontoxic treatment for hepatocellular carcinoma.
    Neoplasia (New York, N.Y.), 2011, Volume: 13, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Proliferation; Drug Combinations; ErbB Receptors; Fluorouracil; Humans; Immunoenzyme Techniques; Lung Neoplasms; Male; Maximum Tolerated Dose; Mice; Mice, Inbred BALB C; Mice, Nude; Oxonic Acid; Piperidines; Quinazolines; Tegafur; Tumor Cells, Cultured

2011
Association analysis of CYP2A6 genotypes and haplotypes with 5-fluorouracil formation from tegafur in human liver microsomes.
    Pharmacogenomics, 2011, Volume: 12, Issue:4

    Topics: Adolescent; Adult; Alleles; Antimetabolites, Antineoplastic; Aryl Hydrocarbon Hydroxylases; Child; Cytochrome P-450 CYP2A6; Female; Fluorouracil; Genotype; Haplotypes; Humans; Male; Microsomes, Liver; Middle Aged; Polymorphism, Genetic; Tegafur; Young Adult

2011
Sorafenib augments cytotoxic effect of S-1 in vitro and in vivo through TS suppression.
    Cancer chemotherapy and pharmacology, 2011, Volume: 68, Issue:6

    Topics: Animals; Antineoplastic Agents; Benzenesulfonates; Carcinoma, Renal Cell; Cell Line, Tumor; Drug Combinations; Drug Synergism; E2F1 Transcription Factor; Female; Fluorouracil; Humans; Kidney Neoplasms; Mice; Mice, Inbred BALB C; Niacinamide; Oxonic Acid; Phenylurea Compounds; Pyridines; RNA, Messenger; Sorafenib; Tegafur; Thymidylate Synthase

2011
Predictive values of 5-fluorouracil pathway genes for S-1 treatment in patients with advanced gastric cancer.
    Anti-cancer drugs, 2011, Volume: 22, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Disease-Free Survival; Drug Combinations; Female; Fluorouracil; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Male; Middle Aged; Multivariate Analysis; Oxonic Acid; Polymerase Chain Reaction; Retrospective Studies; RNA, Messenger; Stomach Neoplasms; Survival; Tegafur; Treatment Outcome; Young Adult

2011
Proteomic differential display analysis for TS-1-resistant and -sensitive pancreatic cancer cells using two-dimensional gel electrophoresis and mass spectrometry.
    Anticancer research, 2011, Volume: 31, Issue:6

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Drug Combinations; Drug Resistance, Neoplasm; Electrophoresis, Gel, Two-Dimensional; Fluorouracil; Humans; Mass Spectrometry; Neoplasm Proteins; Oxonic Acid; Pancreatic Neoplasms; Proteomics; Pyridines; Tegafur

2011
Stereotactic radiosurgery in combination with chemotherapy as primary treatment for head and neck cancer.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2012, Volume: 70, Issue:2

    Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Disease Progression; Drug Combinations; Feasibility Studies; Female; Fluorouracil; Follow-Up Studies; Head and Neck Neoplasms; Humans; Lymphatic Metastasis; Magnetic Resonance Imaging; Male; Middle Aged; Multimodal Imaging; Neoplasm Recurrence, Local; Neoplasm Staging; Oxonic Acid; Patient Care Planning; Positron-Emission Tomography; Radiosurgery; Remission Induction; Retrospective Studies; Survival Rate; Tegafur; Tomography, X-Ray Computed; Treatment Outcome

2012
[Assessment of quality of life by questionnaires between S-1/CPT-11 and mFOLFOX6 in patients with advanced colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2011, Volume: 38, Issue:7

    Topics: Aged; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Drug Combinations; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Organoplatinum Compounds; Oxonic Acid; Quality of Life; Surveys and Questionnaires; Tegafur

2011
Adjuvant radio-chemotherapy after extended or simple cholecystectomy in gallbladder cancer.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2011, Volume: 13, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; Capecitabine; Chemotherapy, Adjuvant; Cholecystectomy; Combined Modality Therapy; Deoxycytidine; Female; Fluorouracil; Follow-Up Studies; Gallbladder Neoplasms; Gemcitabine; Humans; Male; Middle Aged; Radiotherapy, Adjuvant; Survival Rate; Tegafur; Treatment Outcome; Uracil

2011
[Pancreatoduodenectomy for locally advanced ascending colon cancer after neoadjuvant chemotherapy (mFOLFOX6)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2011, Volume: 38, Issue:9

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Combinations; Fluorouracil; Humans; Leucovorin; Male; Neoadjuvant Therapy; Organoplatinum Compounds; Oxonic Acid; Pancreaticoduodenectomy; Tegafur; Tomography, X-Ray Computed

2011
Prognostic significance of glucose transporter-1 (GLUT1) gene expression in rectal cancer after preoperative chemoradiotherapy.
    Surgery today, 2012, Volume: 42, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Cell Line, Tumor; Chemoradiotherapy; Female; Fluorouracil; Gene Expression; Glucose Transporter Type 1; Humans; Ki-67 Antigen; Lymphatic Metastasis; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm, Residual; Preoperative Care; Prognosis; Rectal Neoplasms; Remission Induction; Retrospective Studies; ROC Curve; Tegafur; Tumor Cells, Cultured

2012
Safety and outcome of chemoradiotherapy in elderly patients with rectal cancer: results from two French tertiary centres.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2012, Volume: 44, Issue:4

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Capecitabine; Chemoradiotherapy, Adjuvant; Deoxycytidine; Disease-Free Survival; Female; Fluorouracil; France; Humans; Kaplan-Meier Estimate; Leucovorin; Male; Neoplasm Metastasis; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Rectal Neoplasms; Retrospective Studies; Tegafur; Vitamin B Complex

2012
Antitumor effect of cetuximab in combination with S-1 in EGFR-amplified gastric cancer cells.
    International journal of oncology, 2012, Volume: 40, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cetuximab; Combined Modality Therapy; Drug Combinations; ErbB Receptors; Female; Fluorouracil; Gene Amplification; Humans; Male; Mice; Mice, Nude; Middle Aged; Oxonic Acid; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Stomach Neoplasms; Tegafur; Xenograft Model Antitumor Assays

2012
Reliability of tumor primary cultures as a model for drug response prediction: expression profiles comparison of tissues versus primary cultures from colorectal cancer patients.
    Journal of cancer research and clinical oncology, 2012, Volume: 138, Issue:3

    Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Cisplatin; Colorectal Neoplasms; Deoxycytidine; Down-Regulation; Doxorubicin; Etoposide; Floxuridine; Fluorescent Antibody Technique; Fluorouracil; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genomic Instability; Humans; Irinotecan; Metaphase; Paclitaxel; Polymerase Chain Reaction; Predictive Value of Tests; Protein Array Analysis; Reproducibility of Results; Tegafur; Tissue Array Analysis; Tumor Cells, Cultured; Up-Regulation; Uracil

2012
[Development of oral drugs in the standard therapy for metastatic colorectal cancer patients].
    Nihon rinsho. Japanese journal of clinical medicine, 2011, Volume: 69 Suppl 3

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Drug Therapy, Combination; Fluorouracil; Humans; Irinotecan; Neoplasm Metastasis; Neoplasm Recurrence, Local; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Tegafur

2011
Fluoropyrimidine plus cisplatin for patients with advanced or recurrent gastric cancer with peritoneal metastasis.
    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2013, Volume: 16, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Ascites; Capecitabine; Cisplatin; Deoxycytidine; Disease-Free Survival; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Oxonic Acid; Peritoneal Neoplasms; Retrospective Studies; Stomach Neoplasms; Survival Rate; Tegafur; Time Factors; Treatment Outcome

2013
A retrospective comparison of S-1 plus cisplatin and capecitabine plus cisplatin for patients with advanced or recurrent gastric cancer.
    International journal of clinical oncology, 2013, Volume: 18, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cisplatin; Deoxycytidine; Disease-Free Survival; Drug Combinations; Female; Fluorouracil; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Oxonic Acid; Retrospective Studies; Stomach Neoplasms; Tegafur

2013
Development and utilization of a combined LC-UV and LC-MS/MS method for the simultaneous analysis of tegafur and 5-fluorouracil in human plasma to support a phase I clinical study of oral UFT®/leucovorin.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012, Jun-01, Volume: 898

    Topics: Adenocarcinoma; Administration, Oral; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chromatography, Liquid; Clinical Trials, Phase I as Topic; Esophageal Neoplasms; Fluorouracil; Humans; Middle Aged; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Tegafur

2012
[A case of remnant liver metastases after resection of liver metastases from rectal cancer following treatment with 5-FU, L-OHP and CPT-11, with markedly effective treatment by cetuximab plus S-1].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2012, Volume: 39, Issue:5

    Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cetuximab; Combined Modality Therapy; Drug Combinations; Fluorouracil; Humans; Irinotecan; Liver Neoplasms; Male; Mutation; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Rectal Neoplasms; Recurrence; Salvage Therapy; Tegafur; Tomography, X-Ray Computed

2012
Serum insulin-like growth factor-1 levels predict outcomes of patients with advanced hepatocellular carcinoma receiving antiangiogenic therapy.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, Jul-15, Volume: 18, Issue:14

    Topics: Administration, Metronomic; Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Capecitabine; Carcinoma, Hepatocellular; Clinical Trials as Topic; Deoxycytidine; Fluorouracil; Humans; Insulin-Like Growth Factor I; Liver Neoplasms; Male; Middle Aged; Neoplasm Staging; Niacinamide; Phenylurea Compounds; Prognosis; Serum; Sorafenib; Tegafur; Treatment Outcome

2012
Efficacy of combination chemotherapy using oral fluoropyrimidine S-1 with oxaliplatin (SOX) against colorectal cancer in vivo.
    Anticancer research, 2012, Volume: 32, Issue:7

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Drug Administration Schedule; Drug Combinations; Drug Resistance, Neoplasm; Fluorouracil; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Tegafur; Xenograft Model Antitumor Assays

2012
Multi-institutional analysis of early glottic cancer from 2000 to 2005.
    Radiation oncology (London, England), 2012, Aug-01, Volume: 7

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell; Chemoradiotherapy; Cisplatin; Docetaxel; Female; Fluorouracil; Follow-Up Studies; Glottis; Humans; Laryngeal Neoplasms; Male; Middle Aged; Neoplasm Staging; Prognosis; Survival Rate; Taxoids; Tegafur; Time Factors; Uracil

2012
Early prediction of histopathological response of rectal tumors after one week of preoperative radiochemotherapy using 18 F-FDG PET-CT imaging. A prospective clinical study.
    Radiation oncology (London, England), 2012, Aug-01, Volume: 7

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemoradiotherapy; Deoxycytidine; Female; Fluorodeoxyglucose F18; Fluorouracil; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Multimodal Imaging; Neoplasm Staging; Positron-Emission Tomography; Preoperative Care; Prognosis; Prospective Studies; Radiopharmaceuticals; Radiotherapy Dosage; Rectal Neoplasms; Tegafur; Tomography, X-Ray Computed; Uracil

2012
S-1 in colorectal cancer: a new standard of care?
    The Lancet. Oncology, 2012, Volume: 13, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Female; Fluorouracil; Humans; Male; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Tegafur

2012
[A case of recurrent gastric cancer showing partial response to capecitabine/CDDP after treatment with S-1/CDDP].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2012, Volume: 39, Issue:10

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cisplatin; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Male; Oxonic Acid; Recurrence; Salvage Therapy; Stomach Neoplasms; Tegafur

2012
[Predicting drug efficacy-fluorinated pyrimidines (fluorouracil, S-1 and capecitabine)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2012, Volume: 39, Issue:11

    Topics: Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Neoplasms; Oxonic Acid; Prognosis; Tegafur

2012
An immunoassay method for the pharmacokinetics of 5-fluorouracil in patients with gastric cancer administered adjuvant chemotherapy.
    Anticancer research, 2012, Volume: 32, Issue:11

    Topics: Aged; Antineoplastic Agents; Area Under Curve; Chemotherapy, Adjuvant; Drug Combinations; Female; Fluorouracil; Gas Chromatography-Mass Spectrometry; Humans; Immunoassay; Male; Oxonic Acid; Stomach Neoplasms; Tegafur

2012
Upregulation of ERCC1 and DPD expressions after oxaliplatin-based first-line chemotherapy for metastatic colorectal cancer.
    British journal of cancer, 2012, Dec-04, Volume: 107, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); DNA Topoisomerases, Type I; DNA-Binding Proteins; Drug Combinations; Endonucleases; Female; Fluorouracil; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Leucovorin; Male; Middle Aged; National Cancer Institute (U.S.); Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Real-Time Polymerase Chain Reaction; Retrospective Studies; RNA, Messenger; Tegafur; United States; Up-Regulation

2012
[Prevention of severe toxicity from capecitabine, 5-fluorouracil and tegafur by screening for DPD-deficiency].
    Nederlands tijdschrift voor geneeskunde, 2012, Volume: 156, Issue:48

    Topics: Aged; Antineoplastic Agents; Capecitabine; Deoxycytidine; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Female; Fluorouracil; Genetic Testing; Genotype; Humans; Male; Middle Aged; Neoplasms; Risk Assessment; Tegafur

2012
Evaluation of 5-FU plasma concentration by 13C breath test in patients treated with oral 5-FU analogs.
    Anticancer research, 2012, Volume: 32, Issue:12

    Topics: Acetates; Administration, Oral; Aged; Antimetabolites, Antineoplastic; Breath Tests; Carbon Isotopes; Drug Combinations; Esophageal Neoplasms; Female; Fluorouracil; Humans; Intestinal Absorption; Male; Oxonic Acid; Stomach Neoplasms; Tegafur

2012
Salvage chemoradiotherapy after primary chemotherapy for locally advanced pancreatic cancer: a single-institution retrospective analysis.
    BMC cancer, 2012, Dec-20, Volume: 12

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chemoradiotherapy; Deoxycytidine; Drug Combinations; Female; Fluorouracil; Gemcitabine; Humans; Induction Chemotherapy; Kaplan-Meier Estimate; Male; Middle Aged; Oxonic Acid; Pancreatic Neoplasms; Prognosis; Proportional Hazards Models; Retrospective Studies; Salvage Therapy; Tegafur; Treatment Outcome

2012
[Pharmacokinetics of S-1 capsule in patients with advanced gastric cancer].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2012, Volume: 47, Issue:10

    Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Capsules; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Staging; Oxonic Acid; Pyridines; Stomach Neoplasms; Tegafur; Uracil

2012
REG Iα is a biomarker for predicting response to chemotherapy with S-1 plus cisplatin in patients with unresectable stage IV gastric cancer.
    British journal of cancer, 2013, Feb-05, Volume: 108, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Cell Line, Tumor; Cell Survival; Cisplatin; Drug Combinations; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Lithostathine; Male; Middle Aged; Neoplasm Staging; Oxonic Acid; Stomach Neoplasms; Tegafur; Treatment Outcome

2013
Retrospective study as first-line chemotherapy combined anti-VEGF antibody with fluoropyrimidine for frail patients with unresectable or metastatic colorectal cancer.
    Digestion, 2013, Volume: 87, Issue:1

    Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Colorectal Neoplasms; Drug Combinations; Female; Fluorouracil; Frail Elderly; Humans; Leucovorin; Male; Neoplasm Metastasis; Oxonic Acid; Retrospective Studies; Tegafur; Treatment Failure; Vascular Endothelial Growth Factor A

2013
[Oral chemotherapy for advanced breast cancer].
    Nihon rinsho. Japanese journal of clinical medicine, 2012, Volume: 70 Suppl 7

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Deoxycytidine; Drug Combinations; Female; Fluorouracil; Humans; Molecular Targeted Therapy; Oxonic Acid; Tegafur

2012
The prognostic nutritional index predicts long-term outcomes of gastric cancer patients independent of tumor stage.
    Annals of surgical oncology, 2013, Volume: 20, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Antigen; Chemotherapy, Adjuvant; Cisplatin; Deoxycytidine; Disease-Free Survival; Drug Combinations; Female; Fluorouracil; Gastrectomy; Humans; Lymphatic Metastasis; Lymphocyte Count; Male; Middle Aged; Nutritional Status; Oxonic Acid; Predictive Value of Tests; Retrospective Studies; Serum Albumin; Stomach Neoplasms; Tegafur; Time Factors; Uracil; Young Adult

2013
Salvage radiation therapy and chemoradiation therapy for postoperative locoregional recurrence of esophageal cancer.
    Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 2014, Volume: 27, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Carcinosarcoma; Chemoradiotherapy; Cisplatin; Cohort Studies; Drug Combinations; Esophageal Neoplasms; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Organoplatinum Compounds; Oxonic Acid; Pyridines; Radiotherapy; Retrospective Studies; Salvage Therapy; Survival Rate; Tegafur; Treatment Outcome

2014
New advances in the treatment of gastric cancer.
    Journal of the National Comprehensive Cancer Network : JNCCN, 2004, Volume: 2 Suppl 3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemoradiotherapy, Adjuvant; Chemotherapy, Adjuvant; Cisplatin; Deoxycytidine; Docetaxel; Doxorubicin; Drug Combinations; Etoposide; Fluorouracil; Humans; Leucovorin; Levoleucovorin; Methotrexate; Organoplatinum Compounds; Oxonic Acid; Stomach Neoplasms; Taxoids; Tegafur

2004
Genetic polymorphisms of enzymes related to oral tegafur/uracil therapeutic efficacy in patients with hepatocellular carcinoma.
    Anti-cancer drugs, 2013, Volume: 24, Issue:6

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Aryl Hydrocarbon Hydroxylases; Asian People; Carcinoma, Hepatocellular; Cytochrome P-450 CYP2A6; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Genotype; Hepatitis C; Humans; Japan; Liver Neoplasms; Male; Minisatellite Repeats; Polymorphism, Genetic; Tegafur; Thymidylate Synthase; Uracil

2013
Chemotherapy and resection for gastric cancer with synchronous liver metastases.
    World journal of gastroenterology, 2013, Apr-07, Volume: 19, Issue:13

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Docetaxel; Drug Combinations; Female; Fluorouracil; Glycosylation; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Oxonic Acid; Pilot Projects; Stomach Neoplasms; Taxoids; Tegafur; Treatment Outcome

2013
Clinical comparison between paclitaxel liposome (Lipusu®) and paclitaxel for treatment of patients with metastatic gastric cancer.
    Asian Pacific journal of cancer prevention : APJCP, 2013, Volume: 14, Issue:4

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Female; Fluorouracil; Follow-Up Studies; Humans; Liposomes; Male; Middle Aged; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Prognosis; Retrospective Studies; Stomach Neoplasms; Tegafur

2013
Impact of age on the efficacy of newer adjuvant therapies in patients with stage II/III colon cancer: findings from the ACCENT database.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013, Jul-10, Volume: 31, Issue:20

    Topics: Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Colectomy; Colorectal Neoplasms; Databases, Factual; Deoxycytidine; Disease-Free Survival; Female; Fluorouracil; Humans; Irinotecan; Male; Middle Aged; Organoplatinum Compounds; Prognosis; Pyridines; Randomized Controlled Trials as Topic; Risk Assessment; Survival Analysis; Tegafur; Treatment Outcome

2013
Tegafur + gimeracil + oteracil. Just another fluorouracil precursor.
    Prescrire international, 2013, Volume: 22, Issue:138

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Fluorouracil; Humans; Oxonic Acid; Pyridines; Randomized Controlled Trials as Topic; Stomach Neoplasms; Tegafur

2013
[A case of mediastinal lymph node gastric cancer recurrence during S-1 adjuvant therapy successfully treated with cisplatin + capecitabine as second-line chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2013, Volume: 40, Issue:4

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemotherapy, Adjuvant; Cisplatin; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Lymphatic Metastasis; Male; Oxonic Acid; Stomach Neoplasms; Tegafur

2013
[Approximately four years of survival benefits for a case of gastric cancer postoperative carcinomatous peritonitis by combined modality therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2013, Volume: 40, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Combined Modality Therapy; Drug Combinations; Fatal Outcome; Female; Fluorouracil; Gastrectomy; Humans; Irinotecan; Methotrexate; Middle Aged; Oxonic Acid; Paclitaxel; Peritoneal Neoplasms; Peritonitis; Stomach Neoplasms; Tegafur; Time Factors

2013
[A case of metastatic colon cancer effectively treated by XELOX and IRIS].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2013, Volume: 40, Issue:6

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colonic Neoplasms; Deoxycytidine; Drug Combinations; Female; Fluorouracil; Humans; Irinotecan; Liver Neoplasms; Oxaloacetates; Oxonic Acid; Tegafur; Tomography, X-Ray Computed

2013
Treatment outcome of high-dose-rate interstitial radiation therapy for patients with stage I and II mobile tongue cancer.
    Japanese journal of clinical oncology, 2013, Volume: 43, Issue:10

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Brachytherapy; Carboplatin; Chemoradiotherapy; Cisplatin; Disease-Free Survival; Female; Fluorouracil; Follow-Up Studies; Humans; Infusions, Intravenous; Injections, Intra-Arterial; Kaplan-Meier Estimate; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Oxonic Acid; Pyridines; Radiotherapy Dosage; Retrospective Studies; Tegafur; Tongue Neoplasms; Treatment Outcome

2013
Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing.
    Clinical pharmacology and therapeutics, 2013, Volume: 94, Issue:6

    Topics: Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Genotype; Humans; Incidental Findings; Male; Risk Assessment; Sex Factors; Tegafur

2013
Long-term outcomes and prognostic factors of patients with advanced gastric cancer treated with S-1 plus cisplatin combination chemotherapy as a first-line treatment.
    International journal of clinical oncology, 2014, Volume: 19, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Disease-Free Survival; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Staging; Oxonic Acid; Prognosis; Stomach Neoplasms; Tegafur; Treatment Outcome

2014
Feasibility study of oxaliplatin with oral S-1 or capecitabine as first-line therapy for patients with metastases from colorectal cancer.
    Anticancer research, 2013, Volume: 33, Issue:9

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Disease-Free Survival; Drug Combinations; Feasibility Studies; Female; Fluorouracil; Humans; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Peritoneal Neoplasms; Tegafur

2013
C-reactive protein as predictor of recurrence in patients with rectal cancer undergoing chemoradiotherapy followed by surgery.
    Anticancer research, 2013, Volume: 33, Issue:11

    Topics: Adenocarcinoma, Mucinous; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; C-Reactive Protein; Carcinoembryonic Antigen; Carcinoma, Signet Ring Cell; Chemoradiotherapy; Combined Modality Therapy; Female; Fluorouracil; Follow-Up Studies; Humans; Lymphocytes; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Neutrophils; Prognosis; Rectal Neoplasms; Survival Rate; Tegafur; Uracil

2013
Economic evaluation of first-line adjuvant chemotherapies for resectable gastric cancer patients in China.
    PloS one, 2013, Volume: 8, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bayes Theorem; Capecitabine; Chemotherapy, Adjuvant; China; Clinical Trials, Phase III as Topic; Cost-Benefit Analysis; Deoxycytidine; Disease Progression; Disease-Free Survival; Drug Combinations; Fluorouracil; Gastrectomy; Humans; Markov Chains; Middle Aged; Models, Statistical; Oxaloacetates; Oxonic Acid; Probability; Quality-Adjusted Life Years; Stomach Neoplasms; Tegafur

2013
[A case of hepatocellular carcinoma (Vp4)-combination therapy prolonged survival in a patient with advanced hepatocellular carcinoma with a tumor thrombus in the portal vein trunk].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2013, Volume: 40, Issue:12

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Combined Modality Therapy; Fluorouracil; Hepatectomy; Humans; Liver Neoplasms; Male; Portal Vein; Tegafur; Thrombosis; Time Factors; Treatment Outcome

2013
Usefulness of monthly chemotherapy for patients with unresectable metastatic colorectal cancer.
    Anticancer research, 2014, Volume: 34, Issue:1

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Female; Fluorouracil; Follow-Up Studies; Humans; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Peritoneal Neoplasms; Prognosis; Survival Rate; Tegafur

2014
Twenty-six cases of advanced ampullary adenocarcinoma treated with systemic chemotherapy.
    Japanese journal of clinical oncology, 2014, Volume: 44, Issue:4

    Topics: Adenocarcinoma; Adult; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Common Bile Duct Neoplasms; Disease-Free Survival; Doxorubicin; Female; Fluorouracil; Humans; Male; Medical Records; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Oxonic Acid; Prognosis; Pyridines; Retrospective Studies; Tegafur; Treatment Outcome

2014
A systemic analysis of S-1 regimens for treatment of patients with colon cancer.
    Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:5

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Drug Combinations; Drug-Related Side Effects and Adverse Reactions; Fluorouracil; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Tegafur; Treatment Outcome

2014
Metronomic adjuvant chemotherapy improves treatment outcome in nasopharyngeal carcinoma patients with postradiation persistently detectable plasma Epstein-Barr virus deoxyribonucleic acid.
    International journal of radiation oncology, biology, physics, 2014, May-01, Volume: 89, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Chemotherapy, Adjuvant; Cisplatin; DNA, Viral; Drug Combinations; Epirubicin; Female; Fluorouracil; Herpesvirus 4, Human; Humans; Induction Chemotherapy; Leucovorin; Male; Middle Aged; Mitomycin; Nasopharyngeal Neoplasms; Neoplasm Recurrence, Local; Radiotherapy, Conformal; Retrospective Studies; Tegafur; Treatment Outcome; Uracil

2014
[A case of Stage IV sigmoid colon cancer that achieved long-term survival with oral anticancer drugs].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2014, Volume: 41, Issue:3

    Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Combined Modality Therapy; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Male; Neoplasm Staging; Oxonic Acid; Sigmoid Neoplasms; Tegafur; Time Factors

2014
[A retrospective study of tegafur/uracil compared with cyclophosphamide, methotrexate, and fluorouracil as adjuvant chemotherapy in patients with node-negative, triple-negative breast cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2014, Volume: 41, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cyclophosphamide; Fluorouracil; Humans; Lymphatic Metastasis; Methotrexate; Middle Aged; Recurrence; Retrospective Studies; Tegafur; Triple Negative Breast Neoplasms; Uracil

2014
Prognostic Significance of Nodal Ratio in Patients Undergoing Adjuvant Chemoradiotherapy After Curative Resection for Ampullary Cancer.
    American journal of clinical oncology, 2016, Volume: 39, Issue:4

    Topics: Adult; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy, Adjuvant; Common Bile Duct Neoplasms; Disease-Free Survival; Dose Fractionation, Radiation; Female; Fluorouracil; Follow-Up Studies; Humans; Leucovorin; Liver Neoplasms; Lung Neoplasms; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Mitomycin; Neoplasm Recurrence, Local; Pancreaticoduodenectomy; Retrospective Studies; Survival Rate; Tegafur; Treatment Failure

2016
Inferior oncological prognosis of surgery without oral chemotherapy for stage III colon cancer in clinical settings.
    World journal of surgical oncology, 2014, May-10, Volume: 12

    Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colectomy; Colonic Neoplasms; Combined Modality Therapy; Deoxycytidine; Female; Fluorouracil; Follow-Up Studies; Humans; Leucovorin; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Retrospective Studies; Survival Rate; Tegafur; Uracil; Young Adult

2014
[A case of S-1/CDDP-resistant recurrent gastric cancer responsive to capecitabine/CDDP].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2014, Volume: 41, Issue:5

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cisplatin; Combined Modality Therapy; Deoxycytidine; Drug Combinations; Drug Resistance, Neoplasm; Fluorouracil; Humans; Liver Neoplasms; Male; Neoplasm Staging; Oxonic Acid; Stomach Neoplasms; Tegafur

2014
[A case of advanced rectal cancer that showed complete response to the addition of XELOX+bevacizumab therapy to preoperative chemoradiotherapy with S-1/CPT-11].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2014, Volume: 41, Issue:5

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Capecitabine; Chemoradiotherapy; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Irinotecan; Male; Middle Aged; Neoplasm Staging; Oxaloacetates; Oxonic Acid; Rectal Neoplasms; Tegafur

2014
Post-chemoradiation intraoperative electron-beam radiation therapy boost in resected locally advanced rectal cancer: long-term results focused on topographic pattern of locoregional relapse.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2014, Volume: 112, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Electrons; Female; Fluorouracil; Humans; Intraoperative Care; Leucovorin; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Organoplatinum Compounds; Prognosis; Radiotherapy, Conformal; Rectal Neoplasms; Tegafur

2014
Effect of CYP2A6 genetic polymorphism on the metabolic conversion of tegafur to 5-fluorouracil and its enantioselectivity.
    Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:9

    Topics: Cell Line; Coumarins; Cytochrome P-450 CYP2A6; DNA, Complementary; Escherichia coli; Fluorouracil; Humans; Microsomes, Liver; Nicotine; Polymorphism, Genetic; Sf9 Cells; Tegafur

2014
Outcomes in elderly patients treated with a single-agent or combination regimen as first-line chemotherapy for recurrent or metastatic gastric cancer.
    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2015, Volume: 18, Issue:3

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Drug Combinations; Female; Fluorouracil; Humans; Kaplan-Meier Estimate; Leucovorin; Male; Organoplatinum Compounds; Oxonic Acid; Palliative Care; Prognosis; Retrospective Studies; Stomach Neoplasms; Tegafur; Treatment Outcome

2015
Species variation in the enantioselective metabolism of tegafur to 5-fluorouracil among rats, dogs and monkeys.
    The Journal of pharmacy and pharmacology, 2014, Volume: 66, Issue:12

    Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Biological Availability; Cytochrome P-450 Enzyme System; Dogs; Fluorouracil; Injections, Intravenous; Macaca fascicularis; Male; Metabolic Clearance Rate; Microsomes, Liver; Prodrugs; Rats, Sprague-Dawley; Species Specificity; Stereoisomerism; Tegafur

2014
Evaluation of 5-fluorouracil metabolic enzymes as predictors of response to adjuvant chemotherapy outcomes in patients with stage II/III colorectal cancer: a decision-curve analysis.
    World journal of surgery, 2014, Volume: 38, Issue:12

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Chemotherapy, Adjuvant; Colorectal Neoplasms; Decision Support Techniques; Dihydrouracil Dehydrogenase (NADP); Disease-Free Survival; Female; Fluorouracil; Gene Expression; Humans; Leucovorin; Male; Middle Aged; Neoplasm Recurrence, Local; Orotate Phosphoribosyltransferase; Predictive Value of Tests; RNA, Messenger; Tegafur; Thymidine Phosphorylase; Thymidylate Synthase

2014
S-1-Based versus capecitabine-based preoperative chemoradiotherapy in the treatment of locally advanced rectal cancer: a matched-pair analysis.
    PloS one, 2014, Volume: 9, Issue:9

    Topics: Capecitabine; Chemoradiotherapy; Deoxycytidine; Drug Combinations; Female; Fluorouracil; Humans; Male; Matched-Pair Analysis; Middle Aged; Neoplasm Staging; Oxonic Acid; Postoperative Care; Preoperative Care; Rectal Neoplasms; Tegafur; Treatment Outcome

2014
Adaptation of international guidelines for metastatic colorectal cancer: an asian consensus.
    Clinical colorectal cancer, 2014, Volume: 13, Issue:3

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Asia; Bevacizumab; Camptothecin; Capecitabine; Cetuximab; Colonic Neoplasms; Combined Modality Therapy; Deoxycytidine; Drug Combinations; ErbB Receptors; Fluorouracil; Guideline Adherence; Humans; Leucovorin; Liver Neoplasms; Lung Neoplasms; Magnetic Resonance Imaging; Metastasectomy; Neoplasm Staging; Organoplatinum Compounds; Oxaloacetates; Oxonic Acid; Panitumumab; Practice Guidelines as Topic; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Rectal Neoplasms; Tegafur; Tomography, X-Ray Computed

2014
[A case of gastric cancer with peritoneal dissemination successfully treated with low-dose S-1 or capecitabine chemotherapy for five years].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2014, Volume: 41, Issue:9

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Drug Combinations; Fatal Outcome; Fluorouracil; Humans; Male; Oxonic Acid; Peritoneal Neoplasms; Stomach Neoplasms; Tegafur; Time Factors

2014
Adjuvant chemoradiation with 5-fluorouracil/leucovorin versus S-1 in gastric cancer patients following D2 lymph node dissection surgery: a feasibility study.
    Anticancer research, 2014, Volume: 34, Issue:11

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Signet Ring Cell; Chemoradiotherapy, Adjuvant; Combined Modality Therapy; Drug Combinations; Feasibility Studies; Female; Fluorouracil; Follow-Up Studies; Gastrectomy; Humans; Leucovorin; Lymph Node Excision; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Oxonic Acid; Prognosis; Retrospective Studies; Stomach Neoplasms; Survival Rate; Tegafur

2014
Cost-effectiveness analysis of adjuvant chemotherapies in patients presenting with gastric cancer after D2 gastrectomy.
    BMC cancer, 2014, Dec-19, Volume: 14

    Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemotherapy, Adjuvant; China; Clinical Trials as Topic; Cost-Benefit Analysis; Deoxycytidine; Disease-Free Survival; Drug Combinations; Fluorouracil; Gastrectomy; Humans; Markov Chains; Models, Economic; Oxaloacetates; Oxonic Acid; Quality-Adjusted Life Years; Stomach Neoplasms; Survival Rate; Tegafur

2014
Surgical outcomes in patients with locally advanced gastric cancer treated with S-1 and oxaliplatin as neoadjuvant chemotherapy.
    World journal of surgical oncology, 2015, Jan-30, Volume: 13

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Combined Modality Therapy; Drug Combinations; Female; Fluorouracil; Follow-Up Studies; Gastrectomy; Humans; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Postoperative Complications; Prognosis; Prospective Studies; Remission Induction; Retrospective Studies; Stomach Neoplasms; Survival Rate; Tegafur; Young Adult

2015
Gastrointestinal toxicities of 5-fluorouracil increase the proportion of regulatory T cells in intestinal tract: advantages of alternate-day S-1 administration.
    International journal of clinical oncology, 2015, Volume: 20, Issue:5

    Topics: Animals; Antimetabolites, Antineoplastic; Disease Models, Animal; Drug Combinations; Fluorouracil; Gastrointestinal Diseases; Gastrointestinal Tract; Male; Mice; Mice, Inbred BALB C; Oxonic Acid; T-Lymphocytes, Regulatory; Tegafur

2015
Multicenter observational cohort study of post-operative treatment for completely resected non-small-cell lung cancer of pathological Stage I (T1 >2 cm and T2 in TNM classification version 6).
    Japanese journal of clinical oncology, 2015, Volume: 45, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Chemotherapy, Adjuvant; Cohort Studies; Disease-Free Survival; Drug Combinations; Female; Fluorouracil; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Oxonic Acid; Patient Selection; Postoperative Period; Prodrugs; Proportional Hazards Models; Tegafur; Uracil

2015
[A case of gastric cancer showing response to first-line XP regimen after lymph node recurrence during the administration of S-1 as postoperative adjuvant chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2014, Volume: 41, Issue:12

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemotherapy, Adjuvant; Cisplatin; Deoxycytidine; Drug Combinations; Female; Fluorouracil; Humans; Lymphatic Metastasis; Oxonic Acid; Recurrence; Salvage Therapy; Stomach Neoplasms; Tegafur

2014
Long-Term Survival of Patient with Epstein-Barr Virus-Positive Gastric Cancer Treated with Chemotherapy: Case Report.
    Journal of gastrointestinal cancer, 2016, Volume: 47, Issue:1

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Combinations; Epstein-Barr Virus Infections; Female; Fluorouracil; Follow-Up Studies; Herpesvirus 4, Human; Humans; Male; Middle Aged; Neoplasm Staging; Oxonic Acid; Paclitaxel; Prognosis; Stomach Neoplasms; Survival Rate; Tegafur; Time Factors

2016
Modified FOLFIRINOX for Locally Advanced and Metastatic Pancreatic Cancer Patients Resistant to Gemcitabine and S-1 in Japan: A Single Institutional Experience.
    Hepato-gastroenterology, 2014, Volume: 61, Issue:131

    Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Deoxycytidine; Disease Progression; Disease-Free Survival; Drug Combinations; Drug Resistance, Neoplasm; Female; Fluorouracil; Gemcitabine; Humans; Irinotecan; Japan; Kaplan-Meier Estimate; Leucovorin; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Pancreatic Neoplasms; Tegafur; Time Factors; Treatment Outcome

2014
Lethal leukoencephalopathy secondary to Tegafur, a 5-fluorouracil prodrug.
    Journal of the neurological sciences, 2015, Oct-15, Volume: 357, Issue:1-2

    Topics: Aged; Antimetabolites, Antineoplastic; Fatal Outcome; Fluorouracil; Humans; Leukoencephalopathies; Male; Prodrugs; Tegafur

2015
Development of an S-1 dosage formula based on renal function by a prospective pharmacokinetic study.
    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2016, Volume: 19, Issue:3

    Topics: Aged; Antimetabolites, Antineoplastic; Drug Combinations; Female; Fluorouracil; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Staging; Oxonic Acid; Prognosis; Prospective Studies; Renal Insufficiency; Stomach Neoplasms; Tegafur; Tissue Distribution

2016
Hepatic arterial infusion chemotherapy using fluorouracil, epirubicin, and mitomycin C for patients with liver metastases from gastric cancer after treatment failure of systemic S-1 plus cisplatin.
    Acta radiologica (Stockholm, Sweden : 1987), 2016, Volume: 57, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Catheters, Indwelling; Cisplatin; Disease Progression; Drug Combinations; Epirubicin; Female; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Mitomycin; Oxonic Acid; Stomach Neoplasms; Survival Rate; Tegafur; Tomography, X-Ray Computed; Treatment Failure; Treatment Outcome

2016
Stage III Colon Cancer: The Individualized Strategy of Adjuvant Chemotherapy for Aged Under and Over 70.
    PloS one, 2015, Volume: 10, Issue:9

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Combined Modality Therapy; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Precision Medicine; Prognosis; Retrospective Studies; Tegafur

2015
Tegafur Substitution for 5-Fu in Combination with Actinomycin D to Treat Gestational Trophoblastic Neoplasm.
    PloS one, 2015, Volume: 10, Issue:11

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Dactinomycin; Female; Fluorouracil; Gestational Trophoblastic Disease; Humans; Pregnancy; Tegafur

2015
[The progress of chemotherapy for advanced pancreatic cancer].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2015, Volume: 112, Issue:12

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Drug Combinations; Erlotinib Hydrochloride; Fluorouracil; Gemcitabine; Humans; Leucovorin; Organoplatinum Compounds; Oxonic Acid; Pancreatic Neoplasms; Tegafur

2015
Efficacy and feasibility of ambulatory treatment-based monthly nedaplatin plus S-1 in definitive or salvage concurrent chemoradiotherapy for early, advanced, and relapsed esophageal cancer.
    Radiation oncology (London, England), 2016, Jan-19, Volume: 11

    Topics: Adult; Aged; Aged, 80 and over; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiotherapy; Cisplatin; Drug Administration Schedule; Drug Combinations; Esophageal Neoplasms; Female; Fluorouracil; Hospitalization; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Organoplatinum Compounds; Oxonic Acid; Retrospective Studies; Salvage Therapy; Tegafur

2016
Induction docetaxel and S-1 followed by concomitant radiotherapy with low-dose daily cisplatin in locally advanced head and neck carcinoma.
    Head & neck, 2016, Volume: 38 Suppl 1

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiotherapy; Cisplatin; Docetaxel; Drug Combinations; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Induction Chemotherapy; Male; Middle Aged; Oxonic Acid; Taxoids; Tegafur; Young Adult

2016
[Adjuvant Systemic Chemotherapy with S-1/Oxaliplatin or mFOLFOX6 after Curative Resection of Distant Metastases in Patients with Colorectal Cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2016, Volume: 43, Issue:3

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Drug Combinations; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Rectal Neoplasms; Recurrence; Retrospective Studies; Tegafur

2016
Clinical management of squamous cell carcinoma associated with sinonasal inverted papilloma.
    Auris, nasus, larynx, 2017, Volume: 44, Issue:1

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Squamous Cell; Chemoradiotherapy, Adjuvant; Disease-Free Survival; Drug Combinations; Epistaxis; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Maxillary Sinus Neoplasms; Middle Aged; Nasal Cavity; Nasal Obstruction; Neoplasm Staging; Neoplasms, Multiple Primary; Nose Neoplasms; Otorhinolaryngologic Surgical Procedures; Oxonic Acid; Papilloma, Inverted; Paranasal Sinus Neoplasms; Radiotherapy, Adjuvant; Retrospective Studies; Squamous Cell Carcinoma of Head and Neck; Tegafur; Tomography, X-Ray Computed

2017
Paradoxical Reductions in Serum Anti-p53 Autoantibody Levels by Chemotherapy in Unresectable Colorectal Cancer: An Observational Study.
    Oncology, 2016, Volume: 91, Issue:3

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Autoantibodies; Bevacizumab; Camptothecin; Capecitabine; Carcinoembryonic Antigen; Cetuximab; Colorectal Neoplasms; Disease Progression; Drug Combinations; Female; Fluorouracil; Humans; Leucovorin; Middle Aged; Organoplatinum Compounds; Oxonic Acid; Palliative Care; Pregnancy; Survival Rate; Tegafur; Tumor Suppressor Protein p53

2016
Cytomegalovirus colitis in a patient undergoing postoperative adjuvant chemotherapy for lung adenocarcinoma with uracil-tegafur.
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2016, Volume: 22, Issue:12

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colitis; Cytomegalovirus; Cytomegalovirus Infections; Female; Fluorouracil; Humans; Lung Neoplasms; Postoperative Care; Tegafur

2016
Adult T-cell leukemia/lymphoma in patients with head and neck cancer after S-1 chemotherapy.
    Auris, nasus, larynx, 2017, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Drug Combinations; Female; Fluorouracil; Head and Neck Neoplasms; Human T-lymphotropic virus 1; Humans; Leukemia-Lymphoma, Adult T-Cell; Male; Middle Aged; Neoplasms, Second Primary; Otorhinolaryngologic Surgical Procedures; Oxonic Acid; Radiotherapy; Squamous Cell Carcinoma of Head and Neck; Taxoids; Tegafur

2017
Usefulness of chemoradiotherapy for inoperable gastric cancer.
    Annals of the Royal College of Surgeons of England, 2017, Volume: 99, Issue:4

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Cisplatin; Drug Combinations; Female; Fluorouracil; Humans; Japan; Male; Neoplasm Recurrence, Local; Oxonic Acid; Radiotherapy, Conformal; Retrospective Studies; Stomach Neoplasms; Survival Rate; Tegafur

2017
Paclitaxel/oxaliplatin/fluorouracil (TOF) regimen versus S-1/oxaliplatin (SOX) regimen for metastatic gastric cancer patients.
    Oncotarget, 2017, May-02, Volume: 8, Issue:18

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Paclitaxel; Stomach Neoplasms; Survival Analysis; Tegafur; Tomography, X-Ray Computed; Treatment Outcome; Young Adult

2017
Platinum-based Doublet Chemotherapy for Advanced Gastric Cancer with Disseminated Intravascular Coagulation.
    Anticancer research, 2017, Volume: 37, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Disseminated Intravascular Coagulation; Drug Combinations; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Organoplatinum Compounds; Oxonic Acid; Paclitaxel; Stomach Neoplasms; Tegafur; Treatment Outcome

2017
Short-term efficacy of different chemotherapy regimens in the treatment of advanced gastric cancer: a network meta-analysis.
    Oncotarget, 2017, Jun-06, Volume: 8, Issue:23

    Topics: Capecitabine; Drug Combinations; Fluorouracil; Humans; Network Meta-Analysis; Oxonic Acid; Stomach Neoplasms; Tegafur

2017
Timing of initiation of adjuvant chemotherapy for gastric cancer: A case-matched comparison study of laparoscopic vs. open surgery.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2017, Volume: 43, Issue:4

    Topics: Abdominal Abscess; Adult; Aged; Aged, 80 and over; Anastomotic Leak; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Case-Control Studies; Chemotherapy, Adjuvant; Cisplatin; Deoxycytidine; Drug Combinations; Female; Fluorouracil; Gastrectomy; Humans; Laparoscopy; Laparotomy; Lymph Node Excision; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Oxaloacetates; Oxonic Acid; Pancreatic Fistula; Postoperative Complications; Retrospective Studies; Stomach Neoplasms; Tegafur; Time Factors; Time-to-Treatment

2017
Prediction of Pathological Complete Response Using Endoscopic Findings and Outcomes of Patients Who Underwent Watchful Waiting After Chemoradiotherapy for Rectal Cancer.
    Diseases of the colon and rectum, 2017, Volume: 60, Issue:4

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Antigen; Chemoradiotherapy; Colonoscopy; Digestive System Surgical Procedures; Female; Fluorouracil; Humans; Kaplan-Meier Estimate; Leucovorin; Logistic Models; Lymph Node Excision; Male; Middle Aged; Multivariate Analysis; Neoadjuvant Therapy; Neoplasm Staging; Odds Ratio; Pyridines; Rectal Neoplasms; Rectum; Remission Induction; Retrospective Studies; Tegafur; Treatment Outcome; Watchful Waiting

2017
Comparison of five tumor regression grading systems for gastric adenocarcinoma after neoadjuvant chemotherapy: a retrospective study of 192 cases from National Cancer Center in China.
    BMC gastroenterology, 2017, Mar-14, Volume: 17, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; China; Cisplatin; Disease-Free Survival; Docetaxel; Drug Combinations; Esophagogastric Junction; Female; Fluorouracil; Gastrectomy; Humans; Male; Middle Aged; Multivariate Analysis; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Prognosis; Proportional Hazards Models; Pyridines; Remission Induction; Retrospective Studies; Stomach Neoplasms; Survival Analysis; Taxoids; Tegafur; Treatment Outcome; Tumor Burden

2017
Oral tegafur-uracil as metronomic therapy following intravenous FOLFOX for stage III colon cancer.
    PloS one, 2017, Volume: 12, Issue:3

    Topics: Administration, Intravenous; Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Disease-Free Survival; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Staging; Organoplatinum Compounds; Retrospective Studies; Survival Rate; Tegafur; Uracil

2017
Tegafur/gimeracil/oteracil (TS-1)-induced erythroderma with an extensive mucosal involvement and hand-foot syndrome.
    European journal of dermatology : EJD, 2017, 06-01, Volume: 27, Issue:3

    Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dermatitis, Exfoliative; Drug Combinations; Drug Eruptions; Fluorouracil; Hand-Foot Syndrome; Humans; Leucovorin; Liver Neoplasms; Male; Organoplatinum Compounds; Oxonic Acid; Pyridines; Tegafur

2017
Gene expression levels of gamma-glutamyl hydrolase in tumor tissues may be a useful biomarker for the proper use of S-1 and tegafur-uracil/leucovorin in preoperative chemoradiotherapy for patients with rectal cancer.
    Cancer chemotherapy and pharmacology, 2017, Volume: 79, Issue:6

    Topics: Adenocarcinoma; Adult; Aged; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Chemoradiotherapy; Combined Modality Therapy; Drug Combinations; Female; Fluorouracil; gamma-Glutamyl Hydrolase; Gene Expression Regulation, Neoplastic; Humans; Leucovorin; Male; Middle Aged; Oxonic Acid; Rectal Neoplasms; Reproducibility of Results; Tegafur; Treatment Outcome

2017
Safe administration of S-1 after 5-fluorouracil-induced cardiotoxicity in a patient with colorectal cancer.
    BMJ case reports, 2017, May-22, Volume: 2017

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cardiotoxicity; Colorectal Neoplasms; Drug Combinations; Fluorouracil; Humans; Male; Oxonic Acid; Pyridines; Tegafur

2017
[A Case of Effective Chemoradiotherapy Using mFOLFOX6 for Locally Advanced Rectal Cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2017, Volume: 44, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemoradiotherapy; Drug Combinations; Fluorouracil; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Organoplatinum Compounds; Oxonic Acid; Rectal Neoplasms; Tegafur; Treatment Outcome

2017
A high throughput immunoassay for the therapeutic drug monitoring of tegafur.
    The Analyst, 2017, Jun-26, Volume: 142, Issue:13

    Topics: Antineoplastic Agents; Drug Monitoring; Enzyme-Linked Immunosorbent Assay; Fluorouracil; Humans; Tegafur

2017
Suggestion of added value by bevacizumab to chemotherapy in patients with unresectable or recurrent small bowel cancer.
    Cancer chemotherapy and pharmacology, 2017, Volume: 80, Issue:2

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Capecitabine; Cisplatin; Disease-Free Survival; Drug Combinations; Female; Fluorouracil; Humans; Intestinal Neoplasms; Intestine, Small; Japan; Leucovorin; Male; Middle Aged; Neoplasm Recurrence, Local; Organoplatinum Compounds; Oxonic Acid; Retrospective Studies; Survival Rate; Tegafur

2017
TS-1 (tegafur/gimeracil/oteracil)-induced systemic lupus erythematosus with skin lesions and anti-Sm antibody.
    European journal of dermatology : EJD, 2017, 12-01, Volume: 27, Issue:6

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Drug Therapy, Combination; Fluorouracil; Gemcitabine; Humans; Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Systemic; Male; Oxonic Acid; Pancreatic Neoplasms; Pyridines; Renal Insufficiency; Tegafur

2017
Effect of Sipjeondaebo-Tang on the Pharmacokinetics of S-1, an Anticancer Agent, in Rats Evaluated by Population Pharmacokinetic Modeling.
    Molecules (Basel, Switzerland), 2017, Sep-07, Volume: 22, Issue:9

    Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Drug Combinations; Drugs, Chinese Herbal; Fluorouracil; Herb-Drug Interactions; Humans; Male; Models, Biological; Oxonic Acid; Pyridines; Rats, Sprague-Dawley; Tegafur

2017
Adoptive immunotherapy combined with FP treatment for head and neck cancer: An in vitro study.
    International journal of oncology, 2017, Volume: 51, Issue:5

    Topics: Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Cisplatin; Combined Modality Therapy; Cytomegalovirus; Drug Resistance, Neoplasm; Fluorouracil; Head and Neck Neoplasms; Humans; Immunotherapy, Adoptive; Interferon-gamma; Myeloid-Derived Suppressor Cells; Neoplasm Staging; Phosphoproteins; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Regulatory; Tegafur; Tumor Microenvironment; Uracil; Viral Matrix Proteins

2017
Complete response of metastatic gastric cancer to chemoimmunotherapy.
    The Indian journal of medical research, 2017, Volume: 146, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Combinations; Female; Fluorouracil; Humans; Middle Aged; Neoplasm Metastasis; Oxonic Acid; Paclitaxel; Remission Induction; Stomach Neoplasms; Tegafur

2017
The Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio Are Prognostic Factors in Patients with Locally Advanced Pancreatic Cancer Treated with Chemoradiotherapy.
    Gut and liver, 2018, May-15, Volume: 12, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Blood Platelets; Capecitabine; Chemoradiotherapy; Cisplatin; Deoxycytidine; Disease Progression; Disease-Free Survival; Drug Administration Schedule; Female; Fluorouracil; Gemcitabine; Humans; Lymphocyte Count; Lymphocytes; Male; Middle Aged; Neutrophils; Pancreatic Neoplasms; Platelet Count; Prognosis; Retrospective Studies; Tegafur; Tumor Burden; Uracil

2018
Efficacy of Adjuvant S-1 Versus XELOX Chemotherapy for Patients with Gastric Cancer After D2 Lymph Node Dissection: A Retrospective, Multi-Center Observational Study.
    Annals of surgical oncology, 2018, Volume: 25, Issue:5

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemotherapy, Adjuvant; Deoxycytidine; Disease-Free Survival; Drug Combinations; Female; Fluorouracil; Humans; Lymph Node Excision; Male; Middle Aged; Neoplasm Staging; Oxaloacetates; Oxonic Acid; Retrospective Studies; Stomach Neoplasms; Tegafur

2018
Pre-exposure to Fluorouracil Increased Trifluridine Incorporation and Enhanced its Anti-tumor Effect for Colorectal Cancer.
    Anticancer research, 2018, Volume: 38, Issue:3

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; DNA, Neoplasm; Drug Combinations; Fluorouracil; Humans; Male; Mice, Inbred BALB C; Mice, Nude; Oxonic Acid; Prognosis; Tegafur; Trifluridine; Xenograft Model Antitumor Assays

2018
Adjuvant Chemotherapy Versus Chemoradiotherapy Versus Surgery Alone for Early Gastric Cancer with One or Two Lymph Node Metastasis.
    Annals of surgical oncology, 2018, Volume: 25, Issue:6

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemoradiotherapy, Adjuvant; Chemotherapy, Adjuvant; Cisplatin; Deoxycytidine; Disease-Free Survival; Female; Fluorouracil; Gastrectomy; Humans; Leucovorin; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Oxaliplatin; Oxaloacetates; Oxonic Acid; Pyridines; Radiotherapy Dosage; Stomach Neoplasms; Tegafur

2018
The efficacy of combination of induction chemotherapy and irreversible electroporation ablation for patients with locally advanced pancreatic adenocarcinoma.
    Journal of surgical oncology, 2018, Volume: 118, Issue:1

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Catheter Ablation; Chemotherapy, Adjuvant; Deoxycytidine; Disease-Free Survival; Drug Combinations; Electrochemotherapy; Fluorouracil; Gemcitabine; Humans; Induction Chemotherapy; Laparotomy; Oxonic Acid; Pancreatic Neoplasms; Pyridines; Survival Rate; Tegafur

2018
Determination of 5-fluorouracil and tegafur in tear fluid of patients treated with oral fluoropyrimidine anticancer agent, S-1.
    Japanese journal of ophthalmology, 2018, Volume: 62, Issue:4

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Drug Combinations; Drug Therapy, Combination; Female; Fluorouracil; Humans; Immunosuppressive Agents; Male; Middle Aged; Neoplasms; Oxonic Acid; Tears; Tegafur

2018
[Efficacy of S-1 in Advanced Non-small Cell Lung Cancer Patients Treated 
with More Than Two Lines of Chemotherapy].
    Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2018, Jun-20, Volume: 21, Issue:6

    Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Drug Combinations; Female; Fluorouracil; Humans; Lung Neoplasms; Male; Middle Aged; Oxonic Acid; Retrospective Studies; Safety; Survival Analysis; Tegafur; Treatment Outcome

2018
Efficacy after preoperative capecitabine and oxaliplatin (XELOX) versus docetaxel, oxaliplatin and S1 (DOS) in patients with locally advanced gastric adenocarcinoma: a propensity score matching analysis.
    BMC cancer, 2018, Jun-28, Volume: 18, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemotherapy, Adjuvant; Deoxycytidine; Docetaxel; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Oxaliplatin; Oxaloacetates; Oxonic Acid; Propensity Score; Retrospective Studies; Stomach Neoplasms; Tegafur

2018
Identification of Predictors of Recurrence in Patients with Lower Rectal Cancer Undergoing Neoadjuvant Chemotherapy: A Direct Comparison of Short-Course and Long-Course Chemoradiotherapy.
    Oncology, 2019, Volume: 96, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Neoplasm Staging; Rectal Neoplasms; Retrospective Studies; Survival Rate; Tegafur; Uracil

2019
Clinical efficacy and safety of S-1 monotherapy in the treatment of advanced breast cancer in elderly patients.
    Pakistan journal of pharmaceutical sciences, 2018, Volume: 31, Issue:5(Special)

    Topics: Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Drug Combinations; Female; Fluorouracil; Humans; Middle Aged; Oxonic Acid; Quality of Life; Tegafur; Treatment Outcome

2018
Cost minimization comparison of oral UFT/leucovorin versus 5-fluorouracil/leucovorin as adjuvant therapy for colorectal cancer in Taiwan.
    Journal of comparative effectiveness research, 2019, Volume: 8, Issue:2

    Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Combined Modality Therapy; Cost Control; Female; Fluorouracil; Health Care Costs; Humans; Leucovorin; Male; Middle Aged; Taiwan; Tegafur; Treatment Outcome; Uracil; Vitamin B Complex

2019
A 12-year Recurrence-free Survival After Multidisciplinary Treatment for a Patient With Combined Hepatocellular-Cholangiocarcinoma.
    Anticancer research, 2019, Volume: 39, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Carcinoma, Hepatocellular; Cholangiocarcinoma; Cisplatin; Disease-Free Survival; Female; Fluorouracil; Gamma Rays; Hepatectomy; Humans; Liver Neoplasms; Middle Aged; Mitomycin; Tegafur; Uracil

2019
Fluoropyrimidines and DPD testing: is there truly an inexorable link?
    European journal of cancer (Oxford, England : 1990), 2019, Volume: 113

    Topics: Antineoplastic Agents; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Fluorouracil; Genotype; Humans; Neoplasms; Oxonic Acid; Pharmacogenomic Testing; Phenotype; Point-of-Care Testing; Pyrrolidines; Tegafur; Thymine; Trifluridine; Uracil

2019
Pharmacokinetics of S-1 monotherapy in plasma and in tears for gastric cancer patients.
    International journal of clinical oncology, 2019, Volume: 24, Issue:6

    Topics: Adult; Aged; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Oxonic Acid; Plasma; Prospective Studies; Pyridines; Stomach Neoplasms; Tears; Tegafur; Tissue Distribution

2019
S-1 Monotherapy After Failure of Platinum Plus 5-Fluorouracil Chemotherapy in Recurrent or Metastatic Esophageal Carcinoma.
    Anticancer research, 2019, Volume: 39, Issue:7

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Combinations; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Oxonic Acid; Salvage Therapy; Tegafur; Treatment Failure

2019
Collagen gel droplet-embedded culture drug sensitivity test (CD-DST) predicts the effect of adjuvant chemotherapy on pancreatic cancer.
    Surgery today, 2019, Volume: 49, Issue:12

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Collagen; Drug Combinations; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Fluorouracil; Gels; Humans; Male; Neoplasm Recurrence, Local; Oxonic Acid; Pancreatic Neoplasms; Predictive Value of Tests; Retrospective Studies; Survival Rate; Tegafur; Treatment Outcome

2019
Fluoropyrimidine with or without platinum as first-line chemotherapy in patients with advanced gastric cancer and severe peritoneal metastasis: a multicenter retrospective study.
    BMC cancer, 2019, Jul-03, Volume: 19, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Ascites; Cisplatin; Drug Combinations; Female; Fluorouracil; Humans; Leucovorin; Male; Malnutrition; Methotrexate; Middle Aged; Neutropenia; Organoplatinum Compounds; Oxonic Acid; Peritoneal Neoplasms; Progression-Free Survival; Pyridines; Retrospective Studies; Stomach Neoplasms; Tegafur; Treatment Outcome; Withholding Treatment; Young Adult

2019
Lymph-node ratio is an important clinical determinant for selecting the appropriate adjuvant chemotherapy regimen for curative D2-resected gastric cancer.
    Journal of cancer research and clinical oncology, 2019, Volume: 145, Issue:8

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemotherapy, Adjuvant; Choice Behavior; Cisplatin; Combined Modality Therapy; Deoxycytidine; Female; Fluorouracil; Gastrectomy; Humans; Lymph Node Excision; Lymph Nodes; Male; Middle Aged; Neoplasm Staging; Oxaloacetates; Predictive Value of Tests; Prognosis; Retrospective Studies; Stomach Neoplasms; Survival Analysis; Tegafur; Uracil

2019
[A Case Report of Luminal A Male Inflammatory Breast Cancer that Was Difficult to Treat Because of Trousseau Syndrome].
    Journal of UOEH, 2019, Volume: 41, Issue:2

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms, Male; Cilostazol; Combined Modality Therapy; Cyclophosphamide; Docetaxel; Drug Combinations; Epirubicin; Factor Xa Inhibitors; Fatal Outcome; Fluorouracil; Humans; Inflammatory Breast Neoplasms; Male; Oxonic Acid; Pyridines; Radiotherapy, Intensity-Modulated; Skin Neoplasms; Syndrome; Tegafur; Thiazoles; Thrombophilia

2019
High-throughput method to analyze tegafur and 5-fluorouracil in human tears and plasma using hydrophilic interaction liquid chromatography/tandem mass spectrometry.
    Rapid communications in mass spectrometry : RCM, 2019, Dec-30, Volume: 33, Issue:24

    Topics: Aged; Chromatography, High Pressure Liquid; Female; Fluorouracil; Humans; Hydrophobic and Hydrophilic Interactions; Limit of Detection; Male; Tandem Mass Spectrometry; Tears; Tegafur

2019
Suppressive impact of metronomic chemotherapy using UFT and/or cyclophosphamide on mediators of breast cancer dissemination and invasion.
    PloS one, 2019, Volume: 14, Issue:9

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Cyclophosphamide; Female; Fluorouracil; Humans; Mice; Mice, SCID; Neoplasm Invasiveness; Neovascularization, Pathologic; Tegafur; Uracil; Xenograft Model Antitumor Assays

2019
Tegafur and 5-fluorouracil levels in tears and changes in tear volume in long-term users of the oral anticancer drug S-1.
    Nagoya journal of medical science, 2019, Volume: 81, Issue:3

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Chromatography, Liquid; Drug Combinations; Female; Fluorouracil; Humans; Male; Middle Aged; Oxonic Acid; Quality of Life; Tandem Mass Spectrometry; Tears; Tegafur

2019
Methylation of drug resistance-related genes in chemotherapy-sensitive Epstein-Barr virus-associated gastric cancer.
    FEBS open bio, 2020, Volume: 10, Issue:1

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line; Cisplatin; Cytoskeletal Proteins; DNA Methylation; DNA, Neoplasm; Drug Combinations; Drug Resistance, Neoplasm; Fluorouracil; Frizzled Receptors; Gene Silencing; Herpesvirus 4, Human; Humans; Male; Middle Aged; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Oxonic Acid; Promoter Regions, Genetic; Proto-Oncogene Proteins c-bcl-2; Stomach Neoplasms; Tegafur; Tumor Protein p73

2020
Plasma microRNA profiles: identification of miR-1229-3p as a novel chemoresistant and prognostic biomarker in gastric cancer.
    Scientific reports, 2020, 02-21, Volume: 10, Issue:1

    Topics: Animals; Biomarkers, Tumor; Cell Line, Tumor; Cell Movement; Cell Survival; Disease-Free Survival; Drug Combinations; Drug Resistance, Neoplasm; Female; Fluorouracil; Gastrectomy; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Organic Anion Transporters, Sodium-Independent; Oxonic Acid; Prognosis; Proportional Hazards Models; Stomach Neoplasms; Tegafur

2020
Role of Conversion Surgery for Unresectable Pancreatic Cancer After Long-Term Chemotherapy.
    World journal of surgery, 2020, Volume: 44, Issue:8

    Topics: Aged; Albumins; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Deoxycytidine; Drug Combinations; Female; Fluorouracil; Gemcitabine; Humans; Irinotecan; Kaplan-Meier Estimate; Leucovorin; Lymph Node Excision; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Oxaliplatin; Oxonic Acid; Paclitaxel; Pancreatectomy; Pancreatic Neoplasms; Pancreaticoduodenectomy; Prognosis; Pyridines; Radiotherapy; Retrospective Studies; Tegafur; Time Factors

2020
Population Pharmacokinetic Model-Based Evaluation of Circadian Variations in Plasma 5-Fluorouracil Concentrations During Long-Term Infusion in Rats: A Comparison With Oral Anticancer Prodrugs.
    Journal of pharmaceutical sciences, 2020, Volume: 109, Issue:7

    Topics: Administration, Oral; Animals; Fluorouracil; Prodrugs; Rats; Tegafur; Uracil

2020
Joint Belgian recommendation on screening for DPD-deficiency in patients treated with 5-FU, capecitabine (and tegafur).
    Acta clinica Belgica, 2022, Volume: 77, Issue:2

    Topics: Antimetabolites, Antineoplastic; Belgium; Capecitabine; Dihydropyrimidine Dehydrogenase Deficiency; Fluorouracil; Humans; Tegafur

2022
Simultaneous quantification method for 5-FU, uracil, and tegafur using UPLC-MS/MS and clinical application in monitoring UFT/LV combination therapy after hepatectomy.
    Scientific reports, 2021, 02-04, Volume: 11, Issue:1

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Calibration; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Drug Monitoring; Fluorouracil; Hepatectomy; Humans; Leucovorin; Liver; Liver Neoplasms; Sensitivity and Specificity; Tandem Mass Spectrometry; Tegafur; Uracil

2021
High L-Type Amino Acid Transporter 1 Levels Are Associated with Chemotherapeutic Resistance in Gastric Cancer Patients.
    Oncology, 2021, Volume: 99, Issue:11

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Chemotherapy, Adjuvant; Disease-Free Survival; Drug Combinations; Drug Resistance, Neoplasm; Female; Fluorouracil; Fusion Regulatory Protein-1; Humans; Immunohistochemistry; Large Neutral Amino Acid-Transporter 1; Male; Middle Aged; Neoplasm Recurrence, Local; Oxonic Acid; Phosphorylation; Prognosis; Prospective Studies; Stomach Neoplasms; Tegafur; TOR Serine-Threonine Kinases

2021
Fluoropyridmidine use and hypertriglyceridemia among Japanese patients: analysis of adverse event database.
    International journal of clinical pharmacy, 2022, Volume: 44, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Fluorouracil; Humans; Hypertriglyceridemia; Japan; Tegafur

2022
Successful Immunotherapy for Pancreatic Cancer in a Patient With TSC2 and SMAD4 Mutations: A Case Report.
    Frontiers in immunology, 2021, Volume: 12

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Pancreatic Ductal; DNA Mutational Analysis; Drug Combinations; Drug Resistance, Neoplasm; Fluorouracil; High-Throughput Nucleotide Sequencing; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Mutation; Neoplasm Staging; Oxaliplatin; Oxonic Acid; Pancreatic Neoplasms; Prognosis; Programmed Cell Death 1 Receptor; Response Evaluation Criteria in Solid Tumors; Smad4 Protein; Tegafur; Tuberous Sclerosis Complex 2 Protein

2021
S-1 facilitates canerpaturev (C-REV)-induced antitumor efficacy in a triple-negative breast cancer model.
    Nagoya journal of medical science, 2021, Volume: 83, Issue:4

    Topics: Animals; Antimetabolites, Antineoplastic; CD8-Positive T-Lymphocytes; Drug Combinations; Fluorouracil; Humans; Mice; Neoplasm Recurrence, Local; Oncolytic Viruses; Oxonic Acid; Pyridines; Tegafur; Triple Negative Breast Neoplasms

2021
[A Case Report for Peritoneal Recurrences by Laparoscopic Surgery after Colorectal Cancer Resection].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2022, Volume: 49, Issue:4

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Colonic Neoplasms; Colorectal Neoplasms; Female; Fluorouracil; Humans; Laparoscopy; Leucovorin; Peritoneal Neoplasms; Positron Emission Tomography Computed Tomography; Recurrence; Tegafur

2022
A Pharmacokinetic-Pharmacodynamic Model Predicts Uracil-tegafur Effect on Tumor Shrinkage and Myelosuppression in a Colorectal Cancer Rat Model.
    Anticancer research, 2023, Volume: 43, Issue:3

    Topics: Administration, Oral; Animals; Colorectal Neoplasms; Fluorouracil; Rats; Tegafur; Uracil

2023
Fluoropyrimidine usage in cases with hyperammonemia: real-world data study using the Japanese Adverse Drug Event Report (JADER) database.
    Cancer chemotherapy and pharmacology, 2023, Volume: 92, Issue:1

    Topics: Antimetabolites; Antineoplastic Agents; Capecitabine; Drug-Related Side Effects and Adverse Reactions; Fluorouracil; Humans; Hyperammonemia; Japan; Tegafur

2023