fluorouracil has been researched along with staurosporine in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (10.81) | 18.2507 |
| 2000's | 11 (29.73) | 29.6817 |
| 2010's | 17 (45.95) | 24.3611 |
| 2020's | 5 (13.51) | 2.80 |
| Authors | Studies |
|---|---|
| Bosykh, DA; Burdelya, LG; Chernova, OB; Gudkov, AV; Komarov, PG; Komarova, EA; Macklis, RM; Pavlovska, I; Sathe, S; Shyshynova, I; Skaliter, R; Strom, E | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Li, W; Sun, J; Tang, JF; Wang, XL; Yang, YS; Zhang, YB; Zhu, HL | 1 |
| Qiu, M; Sun, J; Tang, JF; Wang, XL; Yang, YS; Zhang, XM; Zhang, YB; Zhu, HL | 1 |
| Cetin Atalay, R; Guven, EB; Onder, T; Tuncbilek, M | 1 |
| Liu, W; Tang, JF; Wang, XL; Yang, YS; Zhang, YB; Zhu, HL | 1 |
| Sun, J; Yang, ZM; Zhu, H; Zhu, HL | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Shi, J; Wang, SF; Wang, XL; Yang, YS; Yin, Y; Zhang, F; Zhang, WM; Zhu, HL | 1 |
| Abbas, SE; Abdel-Aziz, HA; Abou-Seri, SM; Eladwy, RA; Fares, M; Youssef, MM | 1 |
| Afzal, O; Husain, A; Hussain, A; Mishra, R; Rashid, M; Shaharyar, M | 1 |
| Behl, A; Bhat, KA; Chakraborty, S; Chikan, NA; Farooq, S; Goswami, A; Lone, SH; Mondhe, DM; Nayak, D; Rah, B; Rasool, RU | 1 |
| Amin, S; Jaiswal, AS; Law, BK; Narayan, S; Ramisetti, S; Sharma, AK; Singh, P; Singh-Pillay, A | 1 |
| Han, X; Li, HY; Li, J; Liao, J; Peng, B; Shi, R; Wang, FC; Wang, H; Wang, WZ; Xiao, BB; Xu, X; Yang, CR; Yuan, XL | 1 |
| Afratis, K; Gavras, H; Karamanos, NK; Koutsakis, C; Leonardi, S; Papaioannou, D; Piperigkou, Z; Rassias, G; Rigopoulou, D; Vachlioti, E | 1 |
| Amer, AM; Mohamed, AK; Nafie, MS; Tantawy, ES | 1 |
| Arya, GC; Jaitak, V; Kaur, K | 1 |
| El-Hamamsy, MH; Petreni, A; Supuran, CT; Tawfik, HO | 1 |
| Beltran, P; Fan, D; Fidler, IJ; Killion, JJ; O'Brian, CA; Wilson, MR; Yoon, SS | 1 |
| Tsuchida, E; Urano, M | 1 |
| Hsueh, CT; Kelsen, D; Schwartz, GK | 1 |
| Tieu, K; Yu, PH; Zuo, DM | 1 |
| Abe, S; Furukawa, T; Kitajima, M; Kubota, T; Kumai, K; Otani, Y; Watanabe, M | 1 |
| Abe, S; Hashimoto, M; Hosoda, Y; Kitajima, M; Koh, J; Kubota, T; Migita, T | 1 |
| Campbell, A; Clark, JW; Deluca, P; Eder, JP; Garcia-Carbonero, R; LoRusso, P; Puchalski, TA; Rothermel, J; Ryan, DP; Supko, JG; Wozniak, A | 1 |
| Cockerell, GL; Goodman, JI; McKim, JM; Watson, RE | 1 |
| Comijn, EM; Kamphuis, JA; Peters, GJ; Sigmond, J | 1 |
| Gonen, M; Ilson, DI; Kaubisch, A; Kelsen, DP; Kemeny, N; Kortmansky, J; Maki, RG; O'reilly, E; Saltz, LB; Schwartz, GK; Shah, MA; Sowers, R; Tong, W; Weyerbacher, A; Yi, S | 1 |
| Aquino, A; Baier, S; Bonmassar, E; Correale, PP; De Vecchis, L; Prete, SP; Rossi, L; Tamburrelli, G; Turriziani, M | 1 |
| Benassi, B; Biroccio, A; Zupi, G | 1 |
| Bai, LC; Chan, UP; Chen, GG; Fung, KY; Lai, PB; Merchant, JL; Tessier, A; To, AK | 1 |
| Asoh, S; Miyato, Y; Mizutani, S; Ohta, S; Shidara, Y; Tajiri, T; Tokunaga, A | 1 |
| Aquino, A; Balduzzi, A; Bonmassar, E; Bonmassar, L; Caporaso, P; Cappelletti, D; Cardillo, A; Concolino, F; D'Atri, S; De Vecchis, L; Formica, V; Fossile, E; Graziani, G; Greiner, JW; Prete, SP; Roselli, M; Scoppola, A; Torino, F | 1 |
| Fujinaka, Y; Gillespie, DA; Iimori, M; Kakeji, Y; Kitao, H; Maehara, Y; Matsuoka, K; Morita, M; Saeki, H; Sakasai, R; Takata, M; Tuul, M; Yamamoto, K; Yoshinaga, K | 1 |
| Cuezva, JM; Formentini, L; Sánchez-Aragó, M; Sánchez-Cenizo, L | 1 |
| Beneytout, JL; Bertrand, J; Ghezali, L; Leger, DY; Liagre, B | 1 |
| Choung, S; Fong, EJ; Foo, J; Gasho, J; Hashemi, N; Kim, S; Lau, R; Mumenthaler, SM; Spiller, E; Sun, RX; Ung, N | 1 |
1 review(s) available for fluorouracil and staurosporine
| Article | Year |
|---|---|
Isoxazole derivatives as anticancer agent: A review on synthetic strategies, mechanism of action and SAR studies.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Proliferation; Drug Screening Assays, Antitumor; Female; Humans; Isoxazoles | 2021 |
2 trial(s) available for fluorouracil and staurosporine
| Article | Year |
|---|---|
A phase I trial of daily oral 4'- N -benzoyl-staurosporine in combination with protracted continuous infusion 5-fluorouracil in patients with advanced solid malignancies.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Dose-Response Relationship, Drug; Drug Administration Schedule; Drugs, Investigational; Female; Fluorouracil; Gastrointestinal Diseases; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Staurosporine | 2004 |
Phase I trial of the cyclin-dependent kinase inhibitor and protein kinase C inhibitor 7-hydroxystaurosporine in combination with Fluorouracil in patients with advanced solid tumors.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Female; Fluorouracil; Half-Life; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Protein Kinase Inhibitors; Staurosporine; Treatment Outcome | 2005 |
34 other study(ies) available for fluorouracil and staurosporine
| Article | Year |
|---|---|
Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Benzothiazoles; Cell Line; Dexamethasone; Gamma Rays; Humans; Male; Mice; Mice, Inbred C57BL; Mitochondria; Protein Binding; Protein Transport; Radiation Injuries, Experimental; Radiation-Protective Agents; Thiazoles; Thymus Gland; Toluene; Transcriptional Activation; Tumor Suppressor Protein p53; Ultraviolet Rays | 2006 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Synthesis, biological evaluation and molecular docking studies of 1,3,4-thiadiazole derivatives containing 1,4-benzodioxan as potential antitumor agents.
Topics: Antineoplastic Agents; Cell Proliferation; Dioxanes; Drug Screening Assays, Antitumor; Focal Adhesion Protein-Tyrosine Kinases; Hep G2 Cells; Humans; Liver Neoplasms; Models, Molecular; Protein Binding; Thiadiazoles | 2011 |
Synthesis, biological evaluation, and molecular docking studies of 1,3,4-oxadiazole derivatives possessing 1,4-benzodioxan moiety as potential anticancer agents.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dioxanes; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Dynamics Simulation; Oxadiazoles; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Telomerase | 2011 |
Synthesis of novel 6-(4-substituted piperazine-1-yl)-9-(β-D-ribofuranosyl)purine derivatives, which lead to senescence-induced cell death in liver cancer cells.
Topics: Adenosine; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Death; Cell Line, Tumor; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p15; Drug Screening Assays, Antitumor; Humans; Liver Neoplasms; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Purine Nucleosides; Retinoblastoma Protein; Structure-Activity Relationship | 2012 |
Design, synthesis and biological evaluation of heterocyclic azoles derivatives containing pyrazine moiety as potential telomerase inhibitors.
Topics: Antineoplastic Agents; Apoptosis; Azoles; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Hep G2 Cells; Heterocyclic Compounds; Humans; Models, Molecular; Molecular Structure; Pyrazines; Structure-Activity Relationship; Telomerase | 2012 |
Synthesis, molecular modeling and biological evaluation of 2-aminomethyl-5-(quinolin-2-yl)-1,3,4-oxadiazole-2(3H)-thione quinolone derivatives as novel anticancer agent.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Structure; Oxadiazoles; Quinolines; Structure-Activity Relationship; Telomerase | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Synthesis, molecular modeling and biological evaluation of N-benzylidene-2-((5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl)thio)acetohydrazide derivatives as potential anticancer agents.
Topics: Antineoplastic Agents; Cell Proliferation; Humans; Models, Molecular; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Quantitative Structure-Activity Relationship | 2014 |
Synthesis and antitumor activity of pyrido [2,3-d]pyrimidine and pyrido[2,3-d] [1,2,4]triazolo[4,3-a]pyrimidine derivatives that induce apoptosis through G1 cell-cycle arrest.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Chemistry Techniques, Synthetic; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Pyrimidines; Triazoles | 2014 |
Design and synthesis of pyrimidine molecules endowed with thiazolidin-4-one as new anticancer agents.
Topics: Antineoplastic Agents; Cell Line, Tumor; Chemistry Techniques, Synthetic; Cyclin-Dependent Kinase 2; Drug Design; Humans; Molecular Docking Simulation; Protein Conformation; Structure-Activity Relationship; Thiazolidines | 2014 |
Design and Synthesis of Antitumor Heck-Coupled Sclareol Analogues: Modulation of BH3 Family Members by SS-12 in Autophagy and Apoptotic Cell Death.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Line, Tumor; Diterpenes; Drug Design; Female; Halogenation; Humans; Membrane Proteins; Mice; Proto-Oncogene Proteins c-bcl-2; Salvia; Sarcoma 180; Signal Transduction; TOR Serine-Threonine Kinases | 2015 |
ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells.
Topics: Adamantane; Antineoplastic Agents; Aza Compounds; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Fluorouracil; HCT116 Cells; HT29 Cells; Humans; Molecular Structure; Oxaliplatin; Stem Cells; Structure-Activity Relationship; Tumor Cells, Cultured | 2019 |
Synthesis and evaluation of chalcone analogues containing a 4-oxoquinazolin-2-yl group as potential anti-tumor agents.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chalcones; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Humans; MCF-7 Cells; Mitochondria; Quinazolines; Structure-Activity Relationship | 2019 |
Potent antiproliferative activity of bradykinin B2 receptor selective agonist FR-190997 and analogue structures thereof: A paradox resolved?
Topics: Anti-Bacterial Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; MCF-7 Cells; Quinolines; Receptor, Bradykinin B2 | 2021 |
Discovery of novel pyrazolo[3,4-b]pyridine scaffold-based derivatives as potential PIM-1 kinase inhibitors in breast cancer MCF-7 cells.
Topics: Binding Sites; Breast Neoplasms; Caspase 3; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Drug Design; Drug Evaluation, Preclinical; Female; G2 Phase Cell Cycle Checkpoints; Half-Life; Humans; MCF-7 Cells; Molecular Docking Simulation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-pim-1; Pyrazoles; Pyridines; Structure-Activity Relationship; Tumor Suppressor Protein p53 | 2020 |
Discovery of new carbonic anhydrase IX inhibitors as anticancer agents by toning the hydrophobic and hydrophilic rims of the active site to encounter the dual-tail approach.
Topics: Antineoplastic Agents; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carcinoma, Hepatocellular; Catalytic Domain; Humans; Liver Neoplasms; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship | 2022 |
The antitumor activity of doxorubicin against drug-resistant murine carcinoma is enhanced by oral administration of a synthetic staurosporine analogue, CGP 41251.
Topics: Administration, Oral; Animals; Antibiotics, Antineoplastic; Cell Line; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Therapy, Combination; Enzyme Inhibitors; Fluorouracil; Injections, Intravenous; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; Protein Kinases; Staurosporine; Tumor Cells, Cultured | 1995 |
The effect of UCN-01 (7-hydroxystaurosporine), a potent inhibitor of protein kinase C, on fractionated radiotherapy or daily chemotherapy of a murine fibrosarcoma.
Topics: Alkaloids; Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Fibrosarcoma; Fluorouracil; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Protein Kinase C; Staurosporine; Tumor Stem Cell Assay | 1997 |
UCN-01 suppresses thymidylate synthase gene expression and enhances 5-fluorouracil-induced apoptosis in a sequence-dependent manner.
Topics: Alkaloids; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carrier Proteins; Cell Cycle Proteins; Cyclin-Dependent Kinases; DNA-Binding Proteins; Down-Regulation; Drug Administration Schedule; Drug Synergism; E2F Transcription Factors; E2F1 Transcription Factor; Enzyme Inhibitors; Fluorouracil; Gene Expression; Humans; Protein Kinase C; Retinoblastoma-Binding Protein 1; Staurosporine; Stomach Neoplasms; Thymidylate Synthase; Transcription Factor DP1; Transcription Factors; Tumor Cells, Cultured | 1998 |
Differential effects of staurosporine and retinoic acid on the vulnerability of the SH-SY5Y neuroblastoma cells: involvement of bcl-2 and p53 proteins.
Topics: Benzylamines; Cell Differentiation; Cell Survival; Fluorouracil; Gamma Rays; Humans; Neuroblastoma; Neurotoxins; Oxidopamine; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Tretinoin; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1999 |
UCN-01 (7-hydroxystaurosporine) enhances 5-fluorouracil cytotoxicity through down-regulation of thymidylate synthetase messenger RNA.
Topics: Alkaloids; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Enzyme Inhibitors; Fluorouracil; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Pancreatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Staurosporine; Thymidylate Synthase; Tumor Cells, Cultured | 2000 |
UCN-01 (7-hydroxystaurosporine) inhibits the growth of human breast cancer xenografts through disruption of signal transduction.
Topics: Alkaloids; Animals; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cyclophosphamide; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Estrogens; Female; Fluorouracil; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Hormone-Dependent; Protein Kinase C; Signal Transduction; Staurosporine; Time Factors; Transplantation, Heterologous; Tumor Cells, Cultured | 2002 |
The value of DNA methylation analysis in basic, initial toxicity assessments.
Topics: Animals; Azacitidine; Base Composition; Cell Line, Tumor; Cytosine; DNA Methylation; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fluorouracil; Gene Expression; Guanine; Mutagenicity Tests; Polymerase Chain Reaction; Rats; Rotenone; Staurosporine | 2004 |
Combinations of 5-fluorouracil with UCN-01 or staurosporine.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Separation; Enzyme Inhibitors; Flow Cytometry; Fluorouracil; Humans; Inhibitory Concentration 50; Protein Kinase C; Protein Kinase Inhibitors; Staurosporine; Time Factors | 2004 |
Combined effects of protein kinase inhibitors and 5-fluorouracil on CEA expression in human colon cancer cells.
Topics: Carcinoembryonic Antigen; Cell Line, Tumor; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Synergism; Fluorouracil; Humans; Immunosuppressive Agents; Protein Kinase Inhibitors; Staurosporine | 2005 |
Gamma-glutamylcysteine synthetase mediates the c-Myc-dependent response to antineoplastic agents in melanoma cells.
Topics: Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cisplatin; Fluorouracil; Glutamate-Cysteine Ligase; Glutathione; Humans; Melanoma; Proto-Oncogene Proteins c-myc; Reactive Oxygen Species; Staurosporine | 2007 |
ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Caspase 6; Cell Cycle; Cell Death; Cell Line, Tumor; DNA-Binding Proteins; Flow Cytometry; Fluorouracil; Humans; Liver Neoplasms; S Phase; Staurosporine; Transcription Factors | 2009 |
Mutations in the mitochondrial genome confer resistance of cancer cells to anticancer drugs.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Cell Cycle; Cell Nucleus; Cisplatin; Drug Resistance, Neoplasm; Enzyme Inhibitors; Fluorouracil; Genome, Mitochondrial; Hybrid Cells; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Mutation; Oxygen Consumption; Pancreatic Neoplasms; Staurosporine | 2009 |
Detection of circulating tumor cells is improved by drug-induced antigen up-regulation: preclinical and clinical studies.
Topics: Aged; Aged, 80 and over; Animals; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Carcinoembryonic Antigen; Cell Line, Tumor; Colonic Neoplasms; Enzyme Inhibitors; Female; Fluorouracil; Humans; Immunoblotting; Immunomagnetic Separation; Keratin-19; Male; Mice; Middle Aged; Neoplasm Metastasis; Neoplastic Cells, Circulating; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Up-Regulation | 2010 |
ATR-Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity.
Topics: Animals; Apoptosis; Cell Cycle Proteins; Cell Death; Cell Line, Tumor; Cell Nucleus; Checkpoint Kinase 1; Chickens; Cytoprotection; DNA Breaks, Double-Stranded; Fanconi Anemia Complementation Group D2 Protein; Fluorouracil; Histones; Lymphoma, B-Cell; Mutation; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Recombinational DNA Repair; Signal Transduction; Staurosporine; Time Factors | 2012 |
The mitochondrial ATPase inhibitory factor 1 triggers a ROS-mediated retrograde prosurvival and proliferative response.
Topics: ATPase Inhibitory Protein; bcl-X Protein; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Energy Metabolism; Fluorouracil; HeLa Cells; Humans; I-kappa B Proteins; Mitochondria; NF-kappa B; NF-KappaB Inhibitor alpha; Proteins; Reactive Oxygen Species; Signal Transduction; Staurosporine | 2012 |
Cyclooxygenase-2 positively regulates Akt signalling and enhances survival of erythroleukemia cells exposed to anticancer agents.
Topics: Apoptosis; Arsenic Trioxide; Arsenicals; Casein Kinase II; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclooxygenase 2; Etoposide; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Erythroblastic, Acute; Oxides; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; RNA, Small Interfering; Signal Transduction; Staurosporine | 2013 |
Comparison of Cell and Organoid-Level Analysis of Patient-Derived 3D Organoids to Evaluate Tumor Cell Growth Dynamics and Drug Response.
Topics: Anthracyclines; Cell Proliferation; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Imaging, Three-Dimensional; Irinotecan; Microscopy, Confocal; Organoids; Staurosporine | 2020 |