fluorouracil and phenytoin

fluorouracil has been researched along with phenytoin in 29 studies

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19902 (6.90)18.7374
1990's0 (0.00)18.2507
2000's10 (34.48)29.6817
2010's15 (51.72)24.3611
2020's2 (6.90)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Gozalbes, R; Pineda-Lucena, A1
Ekins, S; Williams, AJ; Xu, JJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M1
Einhorn, R; Franki, N; Hays, RM; Levine, SD1
Scott, JM; Weir, DG1
Brodribb, TR; Gilbar, PJ1
Findlay, M; Rosemergy, I1
Konishi, H; Minouchi, T; Morita, K; Sato, T; Yamaji, A; Yoshimoto, T1
Brickell, K; Porter, D; Thompson, P1
Altundag, K; Beyazit, Y; Elkiran, ET; Guler, N; Kars, A1
Xu, H; Yu, Z1
Fukui, E; Kawahara, K; Sakurai, M; Ueda, R; Yamada, R1
de Los Ríos la Rosa, F; Privitera, M1
Hori, S; Miki, A; Satoh, H; Sawada, Y; Togawa, T; Tsuda, A1
Shimizu, T1
Ibayashi, Y; Jotoku, H; Takahashi, M; Takasaki, M; Tanaka, H; Watanabe, K1
Chai, Z; Li, L; Liu, C; Shen, X; Wang, L; Zhang, X; Zhang, Z1
Taguchi, Y; Takashima, S; Tanaka, K1
Fukui, E; Hori, S; Ikenishi, M; Kawahara, K; Matsuyama, K; Miki, A; Miyazaki, S; Nakatsuka, E; Ohtori, T; Sakurai, M; Satoh, H; Sawada, Y; Ueda, M; Ueda, R1
Keerty, D; Kessler, R; Koverzhenko, V; Peguero, E1

Reviews

3 review(s) available for fluorouracil and phenytoin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Drug-induced megaloblastic change.
    Clinics in haematology, 1980, Volume: 9, Issue:3

    Topics: Cyclophosphamide; Cytarabine; DNA; Erythrocytes, Abnormal; Floxuridine; Fluorouracil; Folic Acid Antagonists; Humans; Hydroxyurea; Megaloblasts; Methotrexate; Phenytoin; Pyrimethamine; Ribonucleotides; Thymidine Monophosphate; Thymidylate Synthase; Triamterene; Trimethoprim

1980
[A case of phenytoin intoxication caused by interaction between phenytoin and capecitabine].
    Brain and nerve = Shinkei kenkyu no shinpo, 2015, Volume: 67, Issue:2

    Topics: Adult; Anticonvulsants; Antineoplastic Agents; Brain Neoplasms; Capecitabine; Deoxycytidine; Drug Interactions; Female; Fluorouracil; Humans; Magnetic Resonance Imaging; Phenytoin

2015

Other Studies

26 other study(ies) available for fluorouracil and phenytoin

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
QSAR-based solubility model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2010, Oct-01, Volume: 18, Issue:19

    Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
    Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3

    Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

2023
Vasopressin-stimulated movement of drugs and uric acid across the toad urinary bladder.
    Kidney international, 1976, Volume: 9, Issue:1

    Topics: Adenine; Animals; Anti-Bacterial Agents; Anura; Butanols; Cell Membrane Permeability; Cyclic AMP; Cyclohexanones; Female; Fluorouracil; Glutethimide; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Phloretin; Stimulation, Chemical; Uric Acid; Urinary Bladder; Vasopressins

1976
Phenytoin and fluorouracil interaction.
    The Annals of pharmacotherapy, 2001, Volume: 35, Issue:11

    Topics: Aged; Anticonvulsants; Antidotes; Antimetabolites, Antineoplastic; Colonic Neoplasms; Drug Interactions; Fluorouracil; Humans; Leucovorin; Male; Phenytoin; Seizures

2001
Phenytoin toxicity as a result of 5-fluorouracil administration.
    The New Zealand medical journal, 2002, Aug-09, Volume: 115, Issue:1159

    Topics: Anticonvulsants; Antimetabolites, Antineoplastic; Drug Interactions; Epilepsy; Female; Fluorouracil; Humans; Middle Aged; Phenytoin; Rectal Neoplasms

2002
Depression of phenytoin metabolic capacity by 5-fluorouracil and doxifluridine in rats.
    The Journal of pharmacy and pharmacology, 2003, Volume: 55, Issue:1

    Topics: Animals; Anticonvulsants; Antimetabolites, Antineoplastic; Cytochrome P-450 Enzyme System; Down-Regulation; Drug Interactions; Floxuridine; Fluorouracil; Male; Microsomes, Liver; Phenytoin; Rats; Rats, Sprague-Dawley

2003
Phenytoin toxicity due to fluoropyrimidines (5FU/capecitabine): three case reports.
    British journal of cancer, 2003, Aug-18, Volume: 89, Issue:4

    Topics: Adenocarcinoma; Administration, Oral; Aged; Anticonvulsants; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Colonic Neoplasms; Deoxycytidine; Drug Interactions; Epilepsy, Generalized; Female; Fluorouracil; Humans; Male; Middle Aged; Phenytoin

2003
Fluorouracil-induced neurotoxicity presenting with generalized tonic-clonic seizure.
    The Annals of pharmacotherapy, 2004, Volume: 38, Issue:12

    Topics: Adenocarcinoma; Anticonvulsants; Antimetabolites, Antineoplastic; Fluorouracil; Humans; Male; Middle Aged; Neurotoxicity Syndromes; Phenytoin; Seizures; Sigmoid Neoplasms

2004
[Establishment of embryonic stem cell for evaluation of development neurotoxicity and test the validation of embryonic stem cell].
    Wei sheng yan jiu = Journal of hygiene research, 2010, Volume: 39, Issue:6

    Topics: Animal Testing Alternatives; Animals; BALB 3T3 Cells; Cell Differentiation; Cells, Cultured; Embryonic Stem Cells; Fluorouracil; Mice; Neurons; Penicillin G; Phenytoin; Reproducibility of Results; Toxicity Tests; Tretinoin

2010
[A case of toxicity caused by drug interaction between capecitabine and phenytoin in patient with colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2011, Volume: 38, Issue:5

    Topics: Adult; Anticonvulsants; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Drug Interactions; Epilepsy; Female; Fluorouracil; Humans; Phenytoin

2011
Capecitabine-phenytoin interaction is dose dependent with an unexpected time course.
    Anti-cancer drugs, 2011, Volume: 22, Issue:10

    Topics: Aged; Anticonvulsants; Antineoplastic Agents; Breast Neoplasms; Capecitabine; Deoxycytidine; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Female; Fluorouracil; Humans; Phenytoin

2011
Sequential interaction of phenytoin and phenobarbital with fluorouracil.
    International journal of clinical pharmacology and therapeutics, 2012, Volume: 50, Issue:12

    Topics: Drug Interactions; Fluorouracil; Humans; Male; Middle Aged; Phenobarbital; Phenytoin

2012
[Ataxia].
    Nihon rinsho. Japanese journal of clinical medicine, 2012, Volume: 70 Suppl 6

    Topics: Anticonvulsants; Antimetabolites, Antineoplastic; Antipsychotic Agents; Ataxia; Fluorouracil; Humans; Lithium; Phenytoin

2012
[Effect of capecitabine therapy on the blood levels of antiepileptic drugs - report of two cases].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2014, Volume: 41, Issue:4

    Topics: Anticonvulsants; Antimetabolites, Antineoplastic; Brain Neoplasms; Breast Neoplasms; Capecitabine; Deoxycytidine; Drug Interactions; Female; Fluorouracil; Humans; Middle Aged; Phenytoin; Seizures; Valproic Acid

2014
A toxicology study to evaluate the embryotoxicity of metformin compared with the hypoglycemic drugs, the anticancer drug, the anti-epileptic drug, the antibiotic, and the cyclo-oxygenase (COX)-2 inhibitor.
    Journal of diabetes, 2015, Volume: 7, Issue:6

    Topics: 3T3 Cells; Animals; Anti-Bacterial Agents; Anticonvulsants; Antineoplastic Agents; Cell Differentiation; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Embryonic Stem Cells; Fibroblasts; Fluorouracil; Gene Expression Regulation, Developmental; Hypoglycemic Agents; Metformin; Mice; Penicillins; Phenytoin; Risk Assessment; Rosiglitazone; Sulfonamides; Sulfonylurea Compounds; Thiazolidinediones

2015
Pharmacokinetic model analysis of interaction between phenytoin and capecitabine.
    International journal of clinical pharmacology and therapeutics, 2016, Volume: 54, Issue:9

    Topics: Administration, Oral; Anticonvulsants; Antimetabolites, Antineoplastic; Capecitabine; Cytochrome P-450 CYP2C9; Drug Interactions; Fluorouracil; Humans; Models, Biological; Nonlinear Dynamics; Phenytoin

2016
Dyskinesia during concomitant usage of phenytoin and capecitabine.
    Postgraduate medical journal, 2021, Volume: 97, Issue:1152

    Topics: Anticonvulsants; Capecitabine; Dyskinesias; Fluorouracil; Humans; Phenytoin

2021